MCID: MNP001
MIFTS: 28

Monophasic Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Monophasic Synovial Sarcoma

MalaCards integrated aliases for Monophasic Synovial Sarcoma:

Name: Monophasic Synovial Sarcoma 12 15 17 70
Monophasic Sarcoma of Synovium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5495
NCIt 50 C6534
UMLS 70 C1334801

Summaries for Monophasic Synovial Sarcoma

MalaCards based summary : Monophasic Synovial Sarcoma, also known as monophasic sarcoma of synovium, is related to sarcoma and extraosseous chondrosarcoma. An important gene associated with Monophasic Synovial Sarcoma is SSX2 (SSX Family Member 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include kidney, cervix and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Monophasic Synovial Sarcoma

Diseases related to Monophasic Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.8 VIM SSX2 SSX1 SS18 S100B MUC1
2 extraosseous chondrosarcoma 30.8 SSX2 SS18
3 chondrosarcoma 30.5 VIM S100B MUC1
4 malignant mesenchymoma 30.4 SSX2 CD34
5 leiomyosarcoma 30.2 VIM S100B MUC1
6 rhabdoid cancer 30.2 VIM SSX2 SS18 MUC1
7 lung sarcoma 30.1 SSX2 SSX1 CD34 CALB2
8 papillary carcinoma 30.1 MUC1 KRT7 KRT19 CALB2
9 epithelioid sarcoma 29.9 VIM MUC1 KRT7 CD34 CALB2
10 neurofibroma 29.8 VIM S100B MUC1 CD34
11 biphasic synovial sarcoma 29.7 VIM TLE1 SSX2 SSX1 SS18 MUC1
12 chordoma 29.7 VIM S100B MUC1 KRT7 KRT19
13 angiosarcoma 29.6 VIM MUC1 KRT7 CD34 CALB2
14 spindle cell sarcoma 29.6 VIM TLE1 SSX2 SSX1 SS18 S100B
15 malignant peripheral nerve sheath tumor 29.4 VIM TLE1 S100B MUC1 KRT7 CD34
16 glomus tumor 29.4 VIM TLE1 MUC1 CD34 CALB2
17 spindle cell synovial sarcoma 29.4 TLE1 SSX2 SSX1 SS18 CD34
18 chondrosarcoma, extraskeletal myxoid 28.9 TLE1 SSX2 SSX1 SS18 CD99 CD34
19 sarcoma, synovial 28.1 VIM TLE1 SSX2 SSX1 SS18 S100B
20 hemangiopericytoma, malignant 28.0 VIM TLE1 SSX2 SSX1 SS18 S100B
21 rare tumor 10.5
22 meninges sarcoma 10.4 SSX2 SS18
23 scrotum paget's disease 10.4 MUC1 KRT7
24 renal pelvis transitional cell carcinoma 10.4 MLH1 KRT7
25 adenosquamous colon carcinoma 10.4 MLH1 KRT7
26 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
27 pancreatic foamy gland adenocarcinoma 10.3 MUC1 KRT7
28 transverse colon cancer 10.3 MLH1 KRT7
29 urinary bladder villous adenoma 10.3 MUC1 KRT7
30 mucinous intrahepatic cholangiocarcinoma 10.3 MUC1 KRT7
31 middle ear adenoma 10.3 MUC1 KRT7
32 jejunal cancer 10.3 MLH1 KRT7
33 bile duct cystadenocarcinoma 10.3 MUC1 KRT7
34 jejunal adenocarcinoma 10.3 MLH1 KRT7
35 apocrine adenocarcinoma 10.3 MUC1 KRT7
36 biliary papillomatosis 10.3 MUC1 KRT7
37 spindle cell thymoma 10.3 MUC1 CALB2
38 bile duct mucoepidermoid carcinoma 10.3 MUC1 KRT7
39 glandular cystitis 10.3 MUC1 KRT7
40 nephrogenic adenoma 10.3 MUC1 KRT7
41 soft tissue sarcoma 10.3
42 lung sarcomatoid carcinoma 10.3 MUC1 CALB2
43 rete testis neoplasm 10.3 KRT7 CALB2
44 rete testis adenocarcinoma 10.3 KRT7 CALB2
45 bartholin's gland disease 10.3 KRT7 CALB2
46 solid adenocarcinoma with mucin production 10.3 MUC1 KRT7
47 papillary tumor of the pineal region 10.3 VIM MUC1
48 epithelioid trophoblastic tumor 10.3 MUC1 KRT7
49 proliferating trichilemmal cyst 10.3 KRT7 KRT19
50 nodular hidradenoma 10.3 VIM MUC1

Graphical network of the top 20 diseases related to Monophasic Synovial Sarcoma:



Diseases related to Monophasic Synovial Sarcoma

Symptoms & Phenotypes for Monophasic Synovial Sarcoma

GenomeRNAi Phenotypes related to Monophasic Synovial Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.23 TLE1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.23 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.23 KRT19
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.23 TLE1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.23 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.23 SSX1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.23 SSX2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.23 SSX2

Drugs & Therapeutics for Monophasic Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Monophasic Synovial Sarcoma

Genetic Tests for Monophasic Synovial Sarcoma

Anatomical Context for Monophasic Synovial Sarcoma

MalaCards organs/tissues related to Monophasic Synovial Sarcoma:

40
Kidney, Cervix, Tongue, Thymus, Cerebellum, Small Intestine, Colon

Publications for Monophasic Synovial Sarcoma

Articles related to Monophasic Synovial Sarcoma:

(show top 50) (show all 201)
# Title Authors PMID Year
1
Primary Synovial Sarcoma of the Uterine Cervix: First Case Report. 61
33075021 2021
2
BNCT for primary synovial sarcoma. 61
33444907 2021
3
Primary Synovial Sarcoma of the Orbit: A Case Report and Update on Diagnostic Techniques. 61
33587418 2021
4
Primary cutaneous synovial sarcoma-Sometimes the hoof beats are zebras. 61
32515062 2021
5
Distant metastatic potential in primary renal sarcoma with MEIS1-NCOA2 gene fusion. 61
33527513 2021
6
Intraneural Synovial Sarcoma of the Median Nerve in a 15-Year-Old Male: A Case Report and Review of Literature. 61
33410716 2021
7
The survival and prognosis analysis of synovial sarcoma subtypes: a Surveillance, Epidemiology, and End Results population-based analysis. 61
32880003 2020
8
Malignant Epithelioid Soft Tissue Tumours- A Pathologist's Perspective With Review of Literature. 61
33520482 2020
9
Synovial Sarcoma of the Female Genital Tract: A Protean Mimic of Müllerian Neoplasia. 61
32675659 2020
10
Monophasic synovial sarcoma of the pyriform fossa. 61
33257363 2020
11
Atypical Vascular Proliferation Secondary to Radiotherapy in a Patient With a History of Synovial Sarcoma. 61
33029459 2020
12
Primary monophasic synovial sarcoma of the cervical esophagus confirmed by detection of the SS18-SSX2 fusion transcripts: case report and literature review. 61
32691176 2020
13
EWSR1-SMAD3-Positive Fibroblastic Tumor. 61
32615834 2020
14
Primary Intraosseous Synovial Sarcoma with Molecular Confirmation: Expanding and Clarifying the Spectrum of This Rare Neoplasm. 61
32082672 2020
15
Synovial Sarcoma of the Hand. 61
32566346 2020
16
Monophasic Synovial Sarcoma of Tongue: A Rarest of Rare Case Scenario. 61
31742025 2019
17
Recurrent monophasic synovial sarcoma in a child. 61
31611466 2019
18
A Rare Case of Synovial Sarcoma Involving the Brachial Plexus, Treated with Wide Local Excision and Reconstructed with Sural Nerve Grafts. 61
32831528 2019
19
Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature. 61
31173483 2019
20
Synovial Sarcoma of Palm Masquerading as a Neural Tumor: A Challenging Differential Diagnosis. 61
31392182 2019
21
An unusual endobronchial lesion: expanding the differential diagnosis. 61
31019717 2019
22
Synovial sarcoma of the hard palate: The third case in the medical literature. 61
28183682 2019
23
Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma. 61
30206413 2019
24
Monophasic synovial sarcoma as a cause of obstructive ileus: A case report. 61
30655996 2019
25
Concurrent Papillary Thyroid Carcinoma and Synovial Carcinoma of the Neck in an Adult Male. 61
30783603 2019
26
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics. 61
29863547 2018
27
Fibroblastic Malignant Peripheral Nerve Sheath Tumour of the Uterine Cervix: Report of a Case and Literature Review With Emphasis on Possible Differential Diagnosis. 61
29474318 2018
28
Case report: synovial sarcoma of the axilla with brachial plexus involvement. 61
30103752 2018
29
Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center. 61
29751751 2018
30
Mediastinal monophasic synovial sarcoma with pericardial extension causing hemodynamic instability. 61
29765618 2018
31
A Rare Case of Monophasic Synovial Sarcoma of Thoracic Vertebra. 61
30581471 2018
32
PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy. 61
30524904 2018
33
Large primary pleural synovial sarcoma with severe dyspnea: a case report. 61
28205183 2017
34
Synovial sarcoma mimicking benign peripheral nerve sheath tumor. 61
28689338 2017
35
Monophasic synovial sarcoma of the greater omentum: case report and review of literature. 61
28660813 2017
36
Primary Cystic Pleuropulmonary Synovial Sarcoma Presenting as Recurrent Pneumothorax. 61
28868028 2017
37
Monophasic synovial sarcoma of posterior pharyngeal wall: a rare case report with unique reconstruction using lateral trapezius flap. 61
27328959 2017
38
Cytologic features of primary monophasic synovial sarcoma of the thyroid gland. 61
29259650 2017
39
High-risk gastrointestinal stromal tumour (GIST) and synovial sarcoma display similar angiogenic profiles: a nude mice xenograft study. 61
28386296 2017
40
Primary poorly differentiated monophasic synovial sarcoma of ileum mesenteries with pulmonary metastasis: a case report. 61
31966464 2017
41
[Villonodular synovitis of the knee: about 20 cases]. 61
29255556 2017
42
[Monophasic synovial sarcoma of the liver: a case report]. 61
27998474 2016
43
Synovial Sarcoma With Myoid Differentiation. 61
27106779 2016
44
A Tumour in Disguise in the Right Palm- Monophasic Synovial Sarcoma. 61
27437233 2016
45
Giant primary synovial sarcoma of the anterior mediastinum: A case report and review of literature. 61
26856298 2016
46
Metastatic synovial sarcoma of the scalp: Case report. 61
25974105 2016
47
Primary pulmonary monophasic synovial sarcoma: Evading diagnosis. 61
26612959 2016
48
[Synovial sarcoma. Case report]. 61
27120724 2016
49
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. 61
26585554 2016
50
A primary intravascular synovial sarcoma causing deep-vein thrombosis and pulmonary embolism in a 20-year-old woman. 61
26628882 2015

Variations for Monophasic Synovial Sarcoma

Expression for Monophasic Synovial Sarcoma

Search GEO for disease gene expression data for Monophasic Synovial Sarcoma.

Pathways for Monophasic Synovial Sarcoma

Pathways related to Monophasic Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 VIM MUC1 KRT7 KRT19
2
Show member pathways
11.17 VIM KRT7 KRT19

GO Terms for Monophasic Synovial Sarcoma

Cellular components related to Monophasic Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 VIM TLE1 SSX2 SSX1 SS18 S100B

Sources for Monophasic Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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