MCID: MNS016
MIFTS: 24

Monosomy 7 of Bone Marrow

Categories: Rare diseases, Bone diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Monosomy 7 of Bone Marrow

MalaCards integrated aliases for Monosomy 7 of Bone Marrow:

Name: Monosomy 7 of Bone Marrow 57 13 73
Chromosome 7q Deletion 57 53
Myelodysplasia and Leukemia Syndrome with Monosomy 7; Mlsm7 57
Myelodysplasia and Leukemia Syndrome with Monosomy 7 57
Partial Monosomy 7q 53
7q Deletion 53
7q Monosomy 53
Deletion 7q 53
Monosomy 7q 53
Mlsm7 57

Characteristics:

OMIM:

57
Inheritance:
?autosomal recessive


Classifications:



Summaries for Monosomy 7 of Bone Marrow

OMIM : 57 Monosomy 7 or partial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute myelogenous leukemia (AML). Furthermore, monosomy 7 or 7q- is the most frequent abnormality of karyotype in cases of AML that occur after cytotoxic cancer therapy or occupational exposure to mutagens. The age distribution of de novo cases shows peaks in the first and fifth decades. Monosomy 7 is found in about 5% of de novo and 40% of secondary cases of AML. These findings suggest that loss of certain genes at this region is an important event in the development of myelodysplasia (summary by Shannon et al., 1989). (252270)

MalaCards based summary : Monosomy 7 of Bone Marrow, also known as chromosome 7q deletion, is related to leukemia and lymphoma. An important gene associated with Monosomy 7 of Bone Marrow is MLSM7 (Myelodysplasia And Leukemia Syndrome With Monosomy 7). Affiliated tissues include bone marrow, bone and myeloid, and related phenotypes are thrombocytopenia and myelodysplasia

NIH Rare Diseases : 53 Chromosome 7q deletion is a chromosome abnormality that occurs when there is a missing copy of the genetic material located on the long arm (q) of chromosome 7. The severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved. Features that often occur in people with chromosome 7q deletion include developmental delay, intellectual disability, behavioral problems, and distinctive facial features. Most cases are not inherited, but people can pass the deletion on to their children. Treatment is based on the signs and symptoms present in each person.

Related Diseases for Monosomy 7 of Bone Marrow

Diseases related to Monosomy 7 of Bone Marrow via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.0
2 lymphoma 10.0
3 splenic marginal zone lymphoma 10.0
4 centralopathic epilepsy 9.8
5 epilepsy 9.8
6 benign epilepsy with centrotemporal spikes 9.8
7 down syndrome 9.7
8 cystic fibrosis 9.7
9 myelodysplastic syndrome 9.7
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
11 holoprosencephaly 9.7
12 chromosome 3p duplication 9.7

Graphical network of the top 20 diseases related to Monosomy 7 of Bone Marrow:



Diseases related to Monosomy 7 of Bone Marrow

Symptoms & Phenotypes for Monosomy 7 of Bone Marrow

Symptoms via clinical synopsis from OMIM:

57
Heme:
myelodysplasia and acute myelogenous leukemia (aml)
thrombocytopenia
erythrocyte macrocytosis

Lab:
bone marrow monosomy 7 or deletion of the long arm of chromosome 7 (7q22-q34)


Clinical features from OMIM:

252270

Human phenotypes related to Monosomy 7 of Bone Marrow:

32
# Description HPO Frequency HPO Source Accession
1 thrombocytopenia 32 HP:0001873
2 myelodysplasia 32 HP:0002863
3 acute myeloid leukemia 32 HP:0004808
4 increased mean corpuscular volume 32 HP:0005518

Drugs & Therapeutics for Monosomy 7 of Bone Marrow

Search Clinical Trials , NIH Clinical Center for Monosomy 7 of Bone Marrow

Genetic Tests for Monosomy 7 of Bone Marrow

Anatomical Context for Monosomy 7 of Bone Marrow

MalaCards organs/tissues related to Monosomy 7 of Bone Marrow:

41
Bone Marrow, Bone, Myeloid

Publications for Monosomy 7 of Bone Marrow

Articles related to Monosomy 7 of Bone Marrow:

# Title Authors Year
1
Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. ( 9520444 )
1998
2
Benign rolandic epilepsy and chromosome 7q deletion. ( 9075027 )
1997

Variations for Monosomy 7 of Bone Marrow

Expression for Monosomy 7 of Bone Marrow

Search GEO for disease gene expression data for Monosomy 7 of Bone Marrow.

Pathways for Monosomy 7 of Bone Marrow

GO Terms for Monosomy 7 of Bone Marrow

Sources for Monosomy 7 of Bone Marrow

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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