MCID: MRN002
MIFTS: 40

Mooren's Ulcer

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Mooren's Ulcer

MalaCards integrated aliases for Mooren's Ulcer:

Name: Mooren's Ulcer 12 15 74
Mooren Ulcer 12 60
Moorens Ulcer 56

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:10439
ICD9CM 36 370.07
SNOMED-CT 69 22440001
ICD10 34 H16.05
Orphanet 60 ORPHA519408
UMLS 74 C0155072

Summaries for Mooren's Ulcer

MalaCards based summary : Mooren's Ulcer, also known as mooren ulcer, is related to pyoderma gangrenosum and cataract. An important gene associated with Mooren's Ulcer is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are cellular and cardiovascular system

Related Diseases for Mooren's Ulcer

Diseases related to Mooren's Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 pyoderma gangrenosum 30.1 ITGB2 NLRP3
2 cataract 10.3
3 hepatitis 10.3
4 hepatitis c 10.3
5 cortical thymoma 10.2 ICAM1 VCAM1
6 shwartzman phenomenon 10.2 ICAM1 VCAM1
7 brachydactyly, type e2 10.2 ICAM1 VCAM1
8 immune-complex glomerulonephritis 10.2 ICAM1 VCAM1
9 limbal stem cell deficiency 10.2 ICAM1 VCAM1
10 annular erythema 10.2 ICAM1 ITGB2
11 henoch-schoenlein purpura 10.2 ICAM1 VCAM1
12 arteriosclerosis obliterans 10.2 ICAM1 VCAM1
13 autoimmune glomerulonephritis 10.2 ICAM1 ITGB2
14 crescentic glomerulonephritis 10.1 ICAM1 VCAM1
15 dengue disease 10.1 ICAM1 VCAM1
16 oral lichen planus 10.1 ICAM1 VCAM1
17 primary progressive multiple sclerosis 10.1 ICAM1 VCAM1
18 heterophyiasis 10.1 ICAM1 SELE
19 hymenolepiasis 10.1 ICAM1 SELE
20 plummer's disease 10.1 ICAM1 SELE
21 endophthalmitis 10.1 ICAM1 SELE
22 hypersensitivity reaction type iii disease 10.1 ICAM1 SELE
23 keratoconus 10.1
24 neutrophil migration 10.1 ICAM1 ITGB2
25 plasmodium vivax malaria 10.1 ICAM1 SELE
26 vertebrobasilar insufficiency 10.1 ICAM1 SELE
27 conjunctivitis 10.1 ICAM1 NLRP3
28 grange syndrome 10.1 SELE VCAM1
29 cutaneous lupus erythematosus 10.0 ICAM1 SELE
30 scleritis 10.0 ITGB2 SELE
31 microvascular complications of diabetes 5 10.0 ICAM1 VCAM1
32 localized scleroderma 10.0 SELE VCAM1
33 keratitis, hereditary 10.0
34 hepatitis c virus 10.0
35 pyoderma 10.0
36 keratoconjunctivitis 10.0
37 vernal keratoconjunctivitis 10.0
38 maturity-onset diabetes of the young, type 7 10.0 SELE VCAM1
39 allergic contact dermatitis 10.0 ICAM1 SELE
40 trypanosomiasis 10.0 ICAM1 VCAM1
41 pustulosis palmaris et plantaris 10.0 ITGB2 SELE
42 contact dermatitis 10.0 ICAM1 SELE
43 chronic eosinophilic pneumonia 10.0 ICAM1 ITGA4
44 hydrocele 10.0 ICAM1 ITGA4
45 takayasu arteritis 10.0 SELE VCAM1
46 plasmodium falciparum malaria 10.0 ICAM1 SELE
47 antiphospholipid syndrome 10.0 SELE VCAM1
48 peripheral vascular disease 9.9 SELE VCAM1
49 myocarditis 9.9 ICAM1 ITGB2
50 microvascular complications of diabetes 1 9.9 ICAM1 VCAM1

Graphical network of the top 20 diseases related to Mooren's Ulcer:



Diseases related to Mooren's Ulcer

Symptoms & Phenotypes for Mooren's Ulcer

MGI Mouse Phenotypes related to Mooren's Ulcer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
2 cardiovascular system MP:0005385 9.72 ICAM1 ITGA4 ITGB2 SELE VCAM1
3 hematopoietic system MP:0005397 9.63 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
4 immune system MP:0005387 9.43 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
5 mortality/aging MP:0010768 9.1 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1

Drugs & Therapeutics for Mooren's Ulcer

Drugs for Mooren's Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 1
2 Antibodies Phase 1
3 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
2 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Completed NCT00357071

Search NIH Clinical Center for Mooren's Ulcer

Genetic Tests for Mooren's Ulcer

Anatomical Context for Mooren's Ulcer

MalaCards organs/tissues related to Mooren's Ulcer:

42
Eye, Bone

Publications for Mooren's Ulcer

Articles related to Mooren's Ulcer:

(show top 50) (show all 127)
# Title Authors Year
1
Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer. ( 30450301 )
2018
2
Mooren Ulcer in a Child Wearing Orthokeratology Contact Lenses. ( 27755290 )
2018
3
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer. ( 28716777 )
2017
4
Unusual Case of Acute Corneal Hydrops in Mooren's Ulcer Treated with Intracameral Injection of Perfluoropropane. ( 28936057 )
2017
5
Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer. ( 28740737 )
2017
6
Clinical course and outcomes in patients with Mooren ulcer who had cataract surgery. ( 28917404 )
2017
7
Case report: bilateral Mooren ulcer in association with hepatitis C. ( 29212473 )
2017
8
Upregulation of NLRP3 inflammasome components in Mooren's ulcer. ( 27796668 )
2016
9
Mooren's ulcer: 30 years of follow-up. ( 26897333 )
2016
10
Bilateral Mooren's ulcer - Customised corneal graft with additional amniotic membrane graft. ( 26155087 )
2015
11
Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. ( 26180482 )
2015
12
Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. ( 25563762 )
2015
13
Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. ( 26553919 )
2015
14
Corneal topographic analysis of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography. ( 25162758 )
2015
15
Interplay of Immune Cells in Mooren Ulcer. ( 25970436 )
2015
16
Pyoderma gangrenosum with corneal perforation by Mooren's ulcer. ( 24801929 )
2014
17
Mooren's ulcer of the cornea after immune reconstitution. ( 24413266 )
2014
18
Mooren's Ulcer in a Cornea Referral Practice in Korea. ( 24960371 )
2014
19
Interventions for Mooren's ulcer. ( 24452998 )
2014
20
Mooren'S ulcer in ibadan, southwest Nigeria. ( 25717466 )
2013
21
Immunosuppression for Mooren's ulcer: evaluation of the stepladder approach--topical, oral and intravenous immunosuppressive agents. ( 23536419 )
2013
22
Use of amniotic membrane and autologous serum eye drops in Mooren's ulcer. ( 23584659 )
2013
23
Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. ( 24345289 )
2013
24
Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. ( 23292924 )
2013
25
Bilateral Mooren's ulcer in a child secondary to helminthic infestation of the gastrointestinal tract. ( 22661075 )
2012
26
Mooren's ulcer in children. ( 22426948 )
2012
27
Mooren's ulcer or peripheral ulcerative keratitis. ( 22556390 )
2012
28
Boston type 1 keratoprosthesis for severe blinding vernal keratoconjunctivitis and Mooren's ulcer. ( 21424885 )
2011
29
Amniotic membrane transplantation for Mooren's ulcer. ( 21176038 )
2011
30
Mooren's ulcer and amniotic membrane transplant: a simple surgical solution? ( 21749593 )
2011
31
Interventions for Mooren's ulcer. ( 21678352 )
2011
32
The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren's ulcer. ( 21666242 )
2011
33
Adalimumab for Mooren's ulcer. ( 19651317 )
2009
34
Corneoscleral graft in Mooren's ulcer: a case report. ( 19946490 )
2009
35
Chronic hepatitis C virus infection is not associated with Mooren's ulcer. ( 17618247 )
2008
36
HLA-DR17 and Mooren's ulcer in South India. ( 18211934 )
2008
37
Outcome of treatment of mooren ulcer with topical cyclosporine a 2%. ( 18724142 )
2008
38
Autologous serum application in the treatment of Mooren's ulcer. ( 17458797 )
2007
39
Treatment of Mooren's ulcer with topical administration of interferon alfa 2a. ( 17198731 )
2007
40
Clinical characteristics of Mooren's ulcer in South India. ( 17035269 )
2007
41
Hookworm infestation as a risk factor for Mooren's ulcer in South India. ( 17123614 )
2007
42
Favourable response to infliximab in a case of bilateral refractory Mooren's ulcer. ( 18173422 )
2007
43
The involvement of multipotential progenitor cells in Mooren's ulcer. ( 15988806 )
2005
44
Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren's ulcer: a case report. ( 15812773 )
2005
45
A case of Mooren's ulcer associated with a pterygium. ( 16365810 )
2005
46
Cataract surgery in patients with Mooren's ulcer. ( 15767159 )
2005
47
Bilateral Mooren's ulcer in six patients: diagnosis, surgery and histopathology. ( 15085968 )
2004
48
Bone marrow-derived cells are present in Mooren's ulcer. ( 15103206 )
2004
49
Relapsing Mooren's ulcer after amniotic membrane transplantation combined with conjunctival autografting. ( 15051214 )
2004
50
Mooren's ulcer resolved with campath-1H. ( 12812907 )
2003

Variations for Mooren's Ulcer

Expression for Mooren's Ulcer

Search GEO for disease gene expression data for Mooren's Ulcer.

Pathways for Mooren's Ulcer

Pathways related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 ICAM1 ITGA4 ITGB2 VCAM1
2
Show member pathways
13.06 ICAM1 ITGA4 ITGB2 VCAM1
3
Show member pathways
12.48 ICAM1 ITGA4 ITGB2 VCAM1
4
Show member pathways
12.38 ICAM1 ITGA4 ITGB2 VCAM1
5
Show member pathways
12.16 ICAM1 SELE VCAM1
6 12.12 ICAM1 ITGB2 VCAM1
7
Show member pathways
12.01 ITGA4 ITGB2 SELE
8
Show member pathways
11.97 ICAM1 ITGA4 ITGB2 VCAM1
9 11.88 ICAM1 SELE VCAM1
10
Show member pathways
11.85 ICAM1 ITGA4 ITGB2 VCAM1
11 11.78 ICAM1 ITGB2 VCAM1
12 11.75 ICAM1 SELE VCAM1
13 11.75 ICAM1 ITGA4 ITGB2 VCAM1
14 11.69 ICAM1 SELE VCAM1
15 11.65 ICAM1 ITGA4 ITGB2 VCAM1
16 11.63 ICAM1 VCAM1
17 11.61 ICAM1 ITGB2
18 11.57 ITGA4 ITGB2
19 11.55 ICAM1 SELE
20 11.51 ITGB2 NLRP3
21 11.45 ICAM1 ITGB2
22
Show member pathways
11.45 ICAM1 SELE VCAM1
23 11.29 ICAM1 ITGB2
24 11.29 ICAM1 SELE VCAM1
25
Show member pathways
11.25 ITGA4 ITGB2 VCAM1
26 11.18 ICAM1 ITGA4 ITGB2 SELE VCAM1
27 11.15 ICAM1 SELE VCAM1
28 11.15 ICAM1 ITGB2 SELE VCAM1
29 10.99 ICAM1 NLRP3
30 10.9 ICAM1 ITGA4 ITGB2 VCAM1
31 10.78 ICAM1 VCAM1

GO Terms for Mooren's Ulcer

Cellular components related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.5 ICAM1 ITGA4 ITGB2
2 external side of plasma membrane GO:0009897 9.43 ICAM1 ITGB2 VCAM1
3 integrin complex GO:0008305 9.16 ITGA4 ITGB2
4 membrane raft GO:0045121 9.13 ICAM1 ITGB2 SELE
5 cell surface GO:0009986 8.92 ICAM1 ITGA4 ITGB2 VCAM1

Biological processes related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 ITGB2 NLRP3 SELE
2 cytokine-mediated signaling pathway GO:0019221 9.75 ICAM1 ITGB2 VCAM1
3 response to lipopolysaccharide GO:0032496 9.7 ICAM1 SELE VCAM1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.69 ICAM1 ITGB2 NLRP3
5 cell-cell adhesion GO:0098609 9.67 ICAM1 ITGB2 VCAM1
6 regulation of immune response GO:0050776 9.67 ICAM1 ITGA4 ITGB2 VCAM1
7 cell-matrix adhesion GO:0007160 9.63 ITGA4 ITGB2 VCAM1
8 integrin-mediated signaling pathway GO:0007229 9.62 ITGA4 ITGB2
9 B cell differentiation GO:0030183 9.62 ITGA4 VCAM1
10 extracellular matrix organization GO:0030198 9.62 ICAM1 ITGA4 ITGB2 VCAM1
11 interferon-gamma-mediated signaling pathway GO:0060333 9.61 ICAM1 VCAM1
12 regulation of inflammatory response GO:0050727 9.61 NLRP3 SELE
13 response to ionizing radiation GO:0010212 9.59 ICAM1 VCAM1
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ICAM1 ITGB2
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELE VCAM1
16 endodermal cell differentiation GO:0035987 9.57 ITGA4 ITGB2
17 receptor clustering GO:0043113 9.56 ITGA4 ITGB2
18 leukocyte migration GO:0050900 9.56 ICAM1 ITGA4 ITGB2 SELE
19 heterotypic cell-cell adhesion GO:0034113 9.55 ITGA4 ITGB2
20 cell adhesion GO:0007155 9.55 ICAM1 ITGA4 ITGB2 SELE VCAM1
21 cell adhesion mediated by integrin GO:0033627 9.54 ICAM1 ITGB2
22 leukocyte migration involved in inflammatory response GO:0002523 9.48 ITGB2 SELE
23 membrane to membrane docking GO:0022614 9.43 ICAM1 VCAM1
24 leukocyte tethering or rolling GO:0050901 9.13 ITGA4 SELE VCAM1
25 leukocyte cell-cell adhesion GO:0007159 9.02 ICAM1 ITGA4 ITGB2 SELE VCAM1

Molecular functions related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.13 ICAM1 ITGB2 VCAM1
2 cell adhesion molecule binding GO:0050839 8.8 ITGA4 ITGB2 VCAM1

Sources for Mooren's Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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