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MCID: MRN002
MIFTS: 38

Mooren's Ulcer

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mooren's Ulcer

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MalaCards integrated aliases for Mooren's Ulcer:

Name: Mooren's Ulcer 12 15 71
Mooren Ulcer 12 58
Moorens Ulcer 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:10439
ICD9CM 34 370.07
SNOMED-CT 67 22440001
ICD10 32 H16.05
Orphanet 58 ORPHA519408
UMLS 71 C0155072
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Summaries for Mooren's Ulcer

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Disease Ontology : 12 A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema.

MalaCards based summary : Mooren's Ulcer, also known as mooren ulcer, is related to scleritis and pyoderma. An important gene associated with Mooren's Ulcer is S100A12 (S100 Calcium Binding Protein A12), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Immunoglobulins and Autoantibodies have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Mooren's Ulcer

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Diseases related to Mooren's Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.2 SELE ITGB2
2 pyoderma 29.9 NLRP3 ITGB2
3 pyoderma gangrenosum 29.9 NLRP3 ITGB2
4 vasculitis 28.9 VCAM1 SELE ITGB2 ITGA4 ICAM1
5 gastrointestinal ulceration, recurrent, with dysfunctional platelets 11.1
6 corneal ulcer 10.6
7 keratitis, hereditary 10.5
8 cataract 10.4
9 limbal stem cell deficiency 10.3 VCAM1 ICAM1
10 hepatitis c 10.3
11 diabetic peripheral angiopathy 10.3 SELE ICAM1
12 heterophyiasis 10.3 SELE ICAM1
13 toxicodendron dermatitis 10.3 SELE ICAM1
14 background diabetic retinopathy 10.3 VCAM1 ICAM1
15 post-thrombotic syndrome 10.3 VCAM1 ICAM1
16 plummer's disease 10.2 SELE ICAM1
17 grange syndrome 10.2 VCAM1 SELE
18 henoch-schoenlein purpura 10.2 VCAM1 ICAM1
19 oral lichen planus 10.2 VCAM1 ICAM1
20 autoimmune disease 10.2
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
22 corneal disease 10.2
23 corneal edema 10.2
24 eye disease 10.2
25 autoimmune enteropathy 10.2 ITGAL ICAM1
26 intermediate coronary syndrome 10.2 VCAM1 ICAM1
27 arteriosclerosis obliterans 10.2 VCAM1 ICAM1
28 endophthalmitis 10.1 SELE ICAM1
29 annular erythema 10.1 ITGB2 ICAM1
30 microvascular complications of diabetes 1 10.1
31 microvascular complications of diabetes 2 10.1
32 microvascular complications of diabetes 5 10.1
33 keratoconus 10.1
34 corneal neovascularization 10.1
35 regular astigmatism 10.1
36 irregular astigmatism 10.1
37 hepatitis 10.1
38 herpes simplex 10.1
39 neurofibromatosis, type ii 10.0
40 glaucoma, primary open angle 10.0
41 retinal detachment 10.0
42 anemia, hypochromic microcytic, with iron overload 1 10.0
43 peters-plus syndrome 10.0
44 cataract, age-related nuclear 10.0
45 yemenite deaf-blind hypopigmentation syndrome 10.0
46 astigmatism 10.0
47 hepatitis c virus 10.0
48 intraocular pressure quantitative trait locus 10.0
49 hypochromic microcytic anemia 10.0
50 open-angle glaucoma 10.0

Graphical network of the top 20 diseases related to Mooren's Ulcer:



Diseases related to Mooren's Ulcer
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Symptoms & Phenotypes for Mooren's Ulcer

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MGI Mouse Phenotypes related to Mooren's Ulcer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 DHX9 ICAM1 ITGA4 ITGAL ITGB2 NLRP3
2 hematopoietic system MP:0005397 9.56 DHX9 ICAM1 ITGA4 ITGAL ITGB2 NLRP3
3 immune system MP:0005387 9.23 DHX9 ICAM1 ITGA4 ITGAL ITGB2 NLRP3
Sources

Drugs & Therapeutics for Mooren's Ulcer

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Drugs for Mooren's Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Autoantibodies
3 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Immune Responses to Different Antigens in Non Infectious Ocular Inflammatory Diseases Completed NCT00357071

Search NIH Clinical Center for Mooren's Ulcer

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Genetic Tests for Mooren's Ulcer

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Anatomical Context for Mooren's Ulcer

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MalaCards organs/tissues related to Mooren's Ulcer:

40
Eye, T Cells, Bone, Skin, Neutrophil
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Publications for Mooren's Ulcer

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Articles related to Mooren's Ulcer:

(show top 50) (show all 245)
# Title Authors PMID Year
1
Mooren ulcer: an immunopathologic study. 54 61
17077658 2006
2
[A histochemical and immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer]. 54 61
12579925 2000
3
Cytokine-induced calgranulin C expression in keratocytes. 54 61
10219252 1999
4
Cloning and expression of human corneal calgranulin C (CO-Ag). 54 61
9746433 1998
5
Cloning and sequence analysis of human and bovine corneal antigen (CO-Ag) cDNA: identification of host-parasite protein calgranulin C. 54 61
9440166 1997
6
Case of bilateral Mooren's ulcers following filtering surgery using EX-PRESS glaucoma filtering devices. 61
31956729 2020
7
Interferon Alpha 2a and 2b in Ophthalmology: A Review. 61
30950678 2019
8
Terrien marginal degeneration. 61
30316804 2019
9
[Clinical features, treatment distribution and outcomes of Mooren's ulcer]. 61
30772992 2019
10
Aggressive Mooren's Ulcer and challenges in its management: Tale of three patients in pictures. 61
30930676 2019
11
Mooren Ulcer in a Child Wearing Orthokeratology Contact Lenses. 61
27755290 2018
12
Cataract surgery in ocular surface diseases: clinical challenges and outcomes. 61
29210839 2018
13
Etiology and failure analysis of anterior lamellar keratoplasty. 61
29862176 2018
14
Various therapies for ocular surface diseases. 61
29796439 2018
15
Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer. 61
30450301 2018
16
Case report: bilateral Mooren ulcer in association with hepatitis C. 61
29212473 2017
17
Clinical course and outcomes in patients with Mooren ulcer who had cataract surgery. 61
28917404 2017
18
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer. 61
28716777 2017
19
Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases. 61
28619029 2017
20
Management of severe and refractory Mooren's ulcers with rituximab. 61
27450147 2017
21
Unusual Case of Acute Corneal Hydrops in Mooren's Ulcer Treated with Intracameral Injection of Perfluoropropane. 61
28936057 2017
22
Upregulation of NLRP3 inflammasome components in Mooren's ulcer. 61
27796668 2017
23
Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer. 61
28740737 2017
24
Mooren's ulcer: 30 years of follow-up. 61
26897333 2016
25
Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. 61
26553919 2016
26
Mooren's Ulcer in a Cornea Referral Practice in Korea. 61
24960371 2016
27
Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study. 61
25935428 2015
28
Ophthalmological implications of the chronic infections with the hepatitis C Virus. 61
29450318 2015
29
Interplay of Immune Cells in Mooren Ulcer. 61
25970436 2015
30
Bilateral Mooren's ulcer - Customised corneal graft with additional amniotic membrane graft. 61
26155087 2015
31
Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. 61
26180482 2015
32
Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. 61
25563762 2015
33
Deep anterior lamellar keratoplasty using irradiated acellular cornea with amniotic membrane transplantation for intractable ocular surface diseases. 61
25829823 2015
34
Corneal topographic analysis of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography. 61
25162758 2015
35
[Peripheral ulcerative keratitis in a 24-year-old patient]. 61
24046173 2014
36
Partial lamellar keratoplasty for peripheral corneal disease using a graft from the glycerin-preserved corneoscleral rim. 61
24796771 2014
37
Age distribution of various corneal diseases in China by histopathological examination of 3112 surgical specimens. 61
24722694 2014
38
Pyoderma gangrenosum with corneal perforation by Mooren's ulcer. 61
24801929 2014
39
Mooren's ulcer of the cornea after immune reconstitution. 61
24413266 2014
40
Interventions for Mooren's ulcer. 61
24452998 2014
41
Peripheral ulcerative keratitis in association with sarcoidosis. 61
23993305 2013
42
Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. 61
24345289 2013
43
Immunosuppression for Mooren's ulcer: evaluation of the stepladder approach--topical, oral and intravenous immunosuppressive agents. 61
23536419 2013
44
Scleral Patch Graft Augmented Cyanoacrylate Tissue Adhesive for Treatment of Moderate-Sized Noninfectious Corneal Perforations (3.5-4.5 mm). 61
23974883 2013
45
Mooren'S ulcer in ibadan, southwest Nigeria. 61
25717466 2013
46
Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases. 61
23394907 2013
47
Treatment and non-treatment related ocular manifestations in patients with chronic hepatitis B or C. 61
23661529 2013
48
Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. 61
23292924 2013
49
Severe unilateral corneal melting after uneventful phacoemulsification cataract surgery. 61
22686354 2013
50
Use of amniotic membrane and autologous serum eye drops in Mooren's ulcer. 61
23584659 2013
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Variations for Mooren's Ulcer

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Expression for Mooren's Ulcer

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Search GEO for disease gene expression data for Mooren's Ulcer.
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Pathways for Mooren's Ulcer

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Pathways related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.74 VCAM1 S100A12 NLRP3 ITGB2 ITGAL ITGA4
2
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 13.24 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
3
Integrin Pathway 63
Show member pathways
 13.18 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
4
Allograft rejection 1 36
Show member pathways
 12.66 ITGB2 ITGAL ITGA4 ICAM1
5
Degradation of the extracellular matrix 65
Show member pathways
 12.53 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
6
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 64
Show member pathways
 12.41 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
7
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.32 ITGB2 ITGAL ICAM1
8
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.22 VCAM1 SELE ICAM1
9
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 12.16 ITGB2 ITGAL ICAM1
10
Human T-cell leukemia virus 1 infection 36
12.15 ITGB2 ITGAL ICAM1
11
Cell surface interactions at the vascular wall 65
Show member pathways
 12.06 SELE ITGB2 ITGAL ITGA4
12
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.03 ITGB2 ITGAL ITGA4
13
Fluid shear stress and atherosclerosis 36
11.92 VCAM1 SELE ICAM1
14
Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview 64
Show member pathways
 11.91 S100A12 ITGB2 ITGAL ITGA4
15
ECM-receptor interaction 36
Show member pathways
 11.91 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
16
Interleukin-4 and 13 signaling 65
11.83 VCAM1 ITGB2 ICAM1
17
TNF signaling pathway 36
11.82 VCAM1 SELE ICAM1
18
Reelin Pathway (Cajal-Retzius cells) 63
11.8 ITGB2 ITGAL ITGA4
19
Adhesion 4
11.79 VCAM1 ITGB2 ITGA4 ICAM1
20
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.79 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
21
AGE-RAGE signaling pathway in diabetic complications 36
11.76 VCAM1 SELE ICAM1
22
Staphylococcus aureus infection 36
11.73 ITGB2 ITGAL ICAM1
23
Rheumatoid arthritis 36
11.71 ITGB2 ITGAL ICAM1
24
Phagocytosis of Microbes 63
11.66 ITGB2 ITGAL ITGA4
25
Cell adhesion molecules (CAMs) 36
11.6 VCAM1 SELE ITGB2 ITGAL ITGA4 ICAM1
26
G-protein signaling_RhoA regulation pathway 22
11.54 ITGB2 ITGAL ITGA4
27
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.51 VCAM1 SELE ICAM1
28
amb2 Integrin signaling 1
11.35 ITGB2 ICAM1
29
Cytoskeleton remodeling_RalA regulation pathway 22
11.35 ITGB2 ITGAL ITGA4
30
Thromboxane A2 receptor signaling 1
11.35 VCAM1 SELE ICAM1
31
Microglia Activation During Neuroinflammation: Steady-State Microglia 64
11.32 ITGB2 ITGAL
32
Paxillin-dependent events mediated by a4b1 1
Show member pathways
 11.31 VCAM1 ITGB2 ITGAL ITGA4
33
Malaria 36
11.25 VCAM1 SELE ITGB2 ITGAL ICAM1
34
African trypanosomiasis 36
11.24 VCAM1 SELE ICAM1
35
CXCR3-mediated signaling events 1
11.18 ITGB2 ITGAL
36
IL1 and megakaryocytes in obesity 1
11.03 NLRP3 ICAM1
37
LDL Oxidation in Atherogenesis 63
10.82 VCAM1 ICAM1
38
Immune response_Role of integrins in NK cells cytotoxicity 22
10.66 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
Sources

GO Terms for Mooren's Ulcer

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Cellular components related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.91 VCAM1 SELE S100A12 NLRP3 ITGB2 ITGAL
2 cell surface GO:0009986 9.55 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
3 membrane raft GO:0045121 9.5 SELE ITGB2 ICAM1
4 integrin alphaL-beta2 complex GO:0034687 8.96 ITGB2 ITGAL
5 integrin complex GO:0008305 8.8 ITGB2 ITGAL ITGA4

Biological processes related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.91 VCAM1 SELE ITGB2 ITGAL ITGA4 ICAM1
2 cell-cell adhesion GO:0098609 9.84 VCAM1 ITGB2 ITGAL ICAM1
3 cytokine-mediated signaling pathway GO:0019221 9.8 VCAM1 ITGB2 ICAM1
4 extracellular matrix organization GO:0030198 9.8 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
5 response to lipopolysaccharide GO:0032496 9.78 VCAM1 SELE ICAM1
6 cellular response to tumor necrosis factor GO:0071356 9.77 VCAM1 ICAM1 DHX9
7 regulation of immune response GO:0050776 9.77 VCAM1 ITGB2 ITGAL ITGA4 ICAM1
8 integrin-mediated signaling pathway GO:0007229 9.76 ITGB2 ITGAL ITGA4
9 cell-matrix adhesion GO:0007160 9.76 VCAM1 ITGB2 ITGAL ITGA4
10 cellular response to amyloid-beta GO:1904646 9.72 VCAM1 ITGA4 ICAM1
11 leukocyte migration GO:0050900 9.72 SELE ITGB2 ITGAL ITGA4 ICAM1
12 receptor clustering GO:0043113 9.69 ITGB2 ITGAL ITGA4
13 heterotypic cell-cell adhesion GO:0034113 9.67 VCAM1 ITGB2 ITGA4
14 leukocyte tethering or rolling GO:0050901 9.65 VCAM1 SELE ITGA4
15 response to ionizing radiation GO:0010212 9.63 VCAM1 ICAM1
16 inflammatory response GO:0006954 9.63 SELE S100A12 NLRP3 ITGB2 ITGAL DHX9
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 ITGB2 ICAM1
18 endodermal cell differentiation GO:0035987 9.62 ITGB2 ITGA4
19 cell adhesion mediated by integrin GO:0033627 9.61 ITGB2 ICAM1
20 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.59 ITGB2 ICAM1
21 leukocyte migration involved in inflammatory response GO:0002523 9.58 SELE ITGB2
22 membrane to membrane docking GO:0022614 9.57 VCAM1 ICAM1
23 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.56 ITGAL ICAM1
24 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.56 VCAM1 SELE ITGAL ICAM1
25 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.52 VCAM1 ITGA4
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.35 S100A12 NLRP3 ITGB2 ICAM1 DHX9
27 leukocyte cell-cell adhesion GO:0007159 9.1 VCAM1 SELE ITGB2 ITGAL ITGA4 ICAM1

Molecular functions related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.43 ITGB2 ITGAL ICAM1
2 integrin binding GO:0005178 9.33 VCAM1 ITGB2 ICAM1
3 ICAM-3 receptor activity GO:0030369 8.96 ITGB2 ITGAL
4 cell adhesion molecule binding GO:0050839 8.92 VCAM1 ITGB2 ITGAL ITGA4
Sources

Sources for Mooren's Ulcer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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