MCID: MRN002
MIFTS: 38

Mooren's Ulcer

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Mooren's Ulcer

MalaCards integrated aliases for Mooren's Ulcer:

Name: Mooren's Ulcer 12 15 72
Mooren Ulcer 12 59
Moorens Ulcer 55

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:10439
ICD9CM 35 370.07
SNOMED-CT 68 22440001
ICD10 33 H16.05
Orphanet 59 ORPHA519408
UMLS 72 C0155072

Summaries for Mooren's Ulcer

Disease Ontology : 12 A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema.

MalaCards based summary : Mooren's Ulcer, also known as mooren ulcer, is related to microvascular complications of diabetes 5 and scleritis. An important gene associated with Mooren's Ulcer is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are cellular and cardiovascular system

Related Diseases for Mooren's Ulcer

Diseases related to Mooren's Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.2 VCAM1 ICAM1
2 scleritis 30.1 SELE ITGB2
3 microvascular complications of diabetes 1 29.9 VCAM1 ICAM1
4 vasculitis 29.9 VCAM1 SELE ICAM1
5 pyoderma gangrenosum 29.8 NLRP3 ITGB2
6 gastrointestinal ulceration, recurrent, with dysfunctional platelets 11.1
7 corneal ulcer 10.6
8 keratitis, hereditary 10.5
9 cataract 10.4
10 cortical thymoma 10.3 VCAM1 ICAM1
11 shwartzman phenomenon 10.3 VCAM1 ICAM1
12 immune-complex glomerulonephritis 10.3 VCAM1 ICAM1
13 brachydactyly, type e2 10.3 VCAM1 ICAM1
14 limbal stem cell deficiency 10.3 VCAM1 ICAM1
15 hepatitis c 10.3
16 heterophyiasis 10.3 SELE ICAM1
17 arteriosclerosis obliterans 10.3 VCAM1 ICAM1
18 henoch-schoenlein purpura 10.3 VCAM1 ICAM1
19 hymenolepiasis 10.3 SELE ICAM1
20 plummer's disease 10.3 SELE ICAM1
21 crescentic glomerulonephritis 10.2 VCAM1 ICAM1
22 endophthalmitis 10.2 SELE ICAM1
23 hypersensitivity reaction type iii disease 10.2 SELE ICAM1
24 oral lichen planus 10.2 VCAM1 ICAM1
25 dengue disease 10.2 VCAM1 ICAM1
26 autoimmune disease 10.2
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
28 corneal disease 10.2
29 corneal edema 10.2
30 eye disease 10.2
31 primary progressive multiple sclerosis 10.2 VCAM1 ICAM1
32 vertebrobasilar insufficiency 10.2 SELE ICAM1
33 plasmodium vivax malaria 10.2 SELE ICAM1
34 grange syndrome 10.2 VCAM1 SELE
35 cutaneous lupus erythematosus 10.2 SELE ICAM1
36 localized scleroderma 10.2 VCAM1 SELE
37 chronic eosinophilic pneumonia 10.1 ITGA4 ICAM1
38 hydrocele 10.1 ITGA4 ICAM1
39 conjunctivitis 10.1 NLRP3 ICAM1
40 allergic contact dermatitis 10.1 SELE ICAM1
41 maturity-onset diabetes of the young, type 7 10.1 VCAM1 SELE
42 microvascular complications of diabetes 2 10.1
43 keratoconus 10.1
44 corneal neovascularization 10.1
45 regular astigmatism 10.1
46 irregular astigmatism 10.1
47 herpes simplex 10.1
48 contact dermatitis 10.1 SELE ICAM1
49 neurofibromatosis, type ii 10.1
50 retinal detachment 10.1

Graphical network of the top 20 diseases related to Mooren's Ulcer:



Diseases related to Mooren's Ulcer

Symptoms & Phenotypes for Mooren's Ulcer

MGI Mouse Phenotypes related to Mooren's Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
2 cardiovascular system MP:0005385 9.72 ICAM1 ITGA4 ITGB2 SELE VCAM1
3 hematopoietic system MP:0005397 9.63 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
4 immune system MP:0005387 9.43 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1
5 mortality/aging MP:0010768 9.1 ICAM1 ITGA4 ITGB2 NLRP3 SELE VCAM1

Drugs & Therapeutics for Mooren's Ulcer

Drugs for Mooren's Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins
3 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Immune Responses to Different Antigens in Non Infectious Ocular Inflammatory Diseases Completed NCT00357071

Search NIH Clinical Center for Mooren's Ulcer

Genetic Tests for Mooren's Ulcer

Anatomical Context for Mooren's Ulcer

MalaCards organs/tissues related to Mooren's Ulcer:

41
Eye, Bone

Publications for Mooren's Ulcer

Articles related to Mooren's Ulcer:

(show top 50) (show all 244)
# Title Authors PMID Year
1
Mooren ulcer: an immunopathologic study. 9 38
17077658 2006
2
[A histochemical and immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer]. 9 38
12579925 2000
3
Cytokine-induced calgranulin C expression in keratocytes. 9 38
10219252 1999
4
Cloning and expression of human corneal calgranulin C (CO-Ag). 9 38
9746433 1998
5
Cloning and sequence analysis of human and bovine corneal antigen (CO-Ag) cDNA: identification of host-parasite protein calgranulin C. 9 38
9440166 1997
6
Interferon Alpha 2a and 2b in Ophthalmology: A Review. 38
30950678 2019
7
Terrien marginal degeneration. 38
30316804 2019
8
[Clinical features, treatment distribution and outcomes of Mooren's ulcer]. 38
30772992 2019
9
Aggressive Mooren's Ulcer and challenges in its management: Tale of three patients in pictures. 38
30930676 2019
10
Mooren Ulcer in a Child Wearing Orthokeratology Contact Lenses. 38
27755290 2018
11
Cataract surgery in ocular surface diseases: clinical challenges and outcomes. 38
29210839 2018
12
Etiology and failure analysis of anterior lamellar keratoplasty. 38
29862176 2018
13
Various therapies for ocular surface diseases. 38
29796439 2018
14
Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer. 38
30450301 2018
15
Case report: bilateral Mooren ulcer in association with hepatitis C. 38
29212473 2017
16
Clinical course and outcomes in patients with Mooren ulcer who had cataract surgery. 38
28917404 2017
17
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer. 38
28716777 2017
18
Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases. 38
28619029 2017
19
Unusual Case of Acute Corneal Hydrops in Mooren's Ulcer Treated with Intracameral Injection of Perfluoropropane. 38
28936057 2017
20
Management of severe and refractory Mooren's ulcers with rituximab. 38
27450147 2017
21
Upregulation of NLRP3 inflammasome components in Mooren's ulcer. 38
27796668 2017
22
Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer. 38
28740737 2017
23
Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. 38
26553919 2016
24
Mooren's ulcer: 30 years of follow-up. 38
26897333 2016
25
Mooren's Ulcer in a Cornea Referral Practice in Korea. 38
24960371 2016
26
Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study. 38
25935428 2015
27
Ophthalmological implications of the chronic infections with the hepatitis C Virus. 38
29450318 2015
28
Interplay of Immune Cells in Mooren Ulcer. 38
25970436 2015
29
Bilateral Mooren's ulcer - Customised corneal graft with additional amniotic membrane graft. 38
26155087 2015
30
Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. 38
26180482 2015
31
Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. 38
25563762 2015
32
Deep anterior lamellar keratoplasty using irradiated acellular cornea with amniotic membrane transplantation for intractable ocular surface diseases. 38
25829823 2015
33
Corneal topographic analysis of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography. 38
25162758 2015
34
[Peripheral ulcerative keratitis in a 24-year-old patient]. 38
24046173 2014
35
Partial lamellar keratoplasty for peripheral corneal disease using a graft from the glycerin-preserved corneoscleral rim. 38
24796771 2014
36
Age distribution of various corneal diseases in China by histopathological examination of 3112 surgical specimens. 38
24722694 2014
37
Pyoderma gangrenosum with corneal perforation by Mooren's ulcer. 38
24801929 2014
38
Mooren's ulcer of the cornea after immune reconstitution. 38
24413266 2014
39
Interventions for Mooren's ulcer. 38
24452998 2014
40
Peripheral ulcerative keratitis in association with sarcoidosis. 38
23993305 2013
41
Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. 38
24345289 2013
42
Immunosuppression for Mooren's ulcer: evaluation of the stepladder approach--topical, oral and intravenous immunosuppressive agents. 38
23536419 2013
43
Scleral Patch Graft Augmented Cyanoacrylate Tissue Adhesive for Treatment of Moderate-Sized Noninfectious Corneal Perforations (3.5-4.5 mm). 38
23974883 2013
44
Mooren'S ulcer in ibadan, southwest Nigeria. 38
25717466 2013
45
Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases. 38
23394907 2013
46
Treatment and non-treatment related ocular manifestations in patients with chronic hepatitis B or C. 38
23661529 2013
47
Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. 38
23292924 2013
48
Use of amniotic membrane and autologous serum eye drops in Mooren's ulcer. 38
23584659 2013
49
Severe unilateral corneal melting after uneventful phacoemulsification cataract surgery. 38
22686354 2013
50
Mooren ulcer occurring at donor site after contralateral conjunctivolimbal autograft for recurrent pterygium. 38
22580428 2012

Variations for Mooren's Ulcer

Expression for Mooren's Ulcer

Search GEO for disease gene expression data for Mooren's Ulcer.

Pathways for Mooren's Ulcer

Pathways related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 VCAM1 ITGB2 ITGA4 ICAM1
2
Show member pathways
13.06 VCAM1 ITGB2 ITGA4 ICAM1
3
Show member pathways
12.48 VCAM1 ITGB2 ITGA4 ICAM1
4
Show member pathways
12.38 VCAM1 ITGB2 ITGA4 ICAM1
5
Show member pathways
12.16 VCAM1 SELE ICAM1
6 12.12 VCAM1 ITGB2 ICAM1
7
Show member pathways
12.01 SELE ITGB2 ITGA4
8
Show member pathways
11.97 VCAM1 ITGB2 ITGA4 ICAM1
9 11.88 VCAM1 SELE ICAM1
10
Show member pathways
11.86 VCAM1 ITGB2 ITGA4 ICAM1
11 11.78 VCAM1 ITGB2 ICAM1
12 11.76 VCAM1 SELE ICAM1
13 11.75 VCAM1 ITGB2 ITGA4 ICAM1
14 11.69 VCAM1 SELE ICAM1
15 11.66 VCAM1 ICAM1
16 11.65 VCAM1 ITGB2 ITGA4 ICAM1
17 11.62 ITGB2 ICAM1
18 11.6 ITGB2 ICAM1
19 11.57 ITGB2 ITGA4
20 11.55 SELE ICAM1
21 11.51 NLRP3 ITGB2
22
Show member pathways
11.45 VCAM1 SELE ICAM1
23 11.29 ITGB2 ICAM1
24 11.29 VCAM1 SELE ICAM1
25
Show member pathways
11.25 VCAM1 ITGB2 ITGA4
26 11.19 VCAM1 SELE ITGB2 ITGA4 ICAM1
27 11.15 VCAM1 SELE ICAM1
28 11.15 VCAM1 SELE ITGB2 ICAM1
29 10.99 NLRP3 ICAM1
30 10.9 VCAM1 ITGB2 ITGA4 ICAM1
31 10.78 VCAM1 ICAM1

GO Terms for Mooren's Ulcer

Cellular components related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.5 ITGB2 ITGA4 ICAM1
2 external side of plasma membrane GO:0009897 9.43 VCAM1 ITGB2 ICAM1
3 integrin complex GO:0008305 9.16 ITGB2 ITGA4
4 membrane raft GO:0045121 9.13 SELE ITGB2 ICAM1
5 cell surface GO:0009986 8.92 VCAM1 ITGB2 ITGA4 ICAM1

Biological processes related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 SELE NLRP3 ITGB2
2 cytokine-mediated signaling pathway GO:0019221 9.75 VCAM1 ITGB2 ICAM1
3 response to lipopolysaccharide GO:0032496 9.7 VCAM1 SELE ICAM1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.69 NLRP3 ITGB2 ICAM1
5 cell-cell adhesion GO:0098609 9.67 VCAM1 ITGB2 ICAM1
6 regulation of immune response GO:0050776 9.67 VCAM1 ITGB2 ITGA4 ICAM1
7 cell-matrix adhesion GO:0007160 9.63 VCAM1 ITGB2 ITGA4
8 integrin-mediated signaling pathway GO:0007229 9.62 ITGB2 ITGA4
9 B cell differentiation GO:0030183 9.62 VCAM1 ITGA4
10 extracellular matrix organization GO:0030198 9.62 VCAM1 ITGB2 ITGA4 ICAM1
11 regulation of inflammatory response GO:0050727 9.61 SELE NLRP3
12 interferon-gamma-mediated signaling pathway GO:0060333 9.61 VCAM1 ICAM1
13 response to ionizing radiation GO:0010212 9.59 VCAM1 ICAM1
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ITGB2 ICAM1
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 VCAM1 SELE ICAM1
16 endodermal cell differentiation GO:0035987 9.57 ITGB2 ITGA4
17 receptor clustering GO:0043113 9.56 ITGB2 ITGA4
18 leukocyte migration GO:0050900 9.56 SELE ITGB2 ITGA4 ICAM1
19 heterotypic cell-cell adhesion GO:0034113 9.55 ITGB2 ITGA4
20 cell adhesion GO:0007155 9.55 VCAM1 SELE ITGB2 ITGA4 ICAM1
21 cell adhesion mediated by integrin GO:0033627 9.54 ITGB2 ICAM1
22 leukocyte migration involved in inflammatory response GO:0002523 9.48 SELE ITGB2
23 membrane to membrane docking GO:0022614 9.43 VCAM1 ICAM1
24 leukocyte tethering or rolling GO:0050901 9.13 VCAM1 SELE ITGA4
25 leukocyte cell-cell adhesion GO:0007159 9.02 VCAM1 SELE ITGB2 ITGA4 ICAM1

Molecular functions related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.13 VCAM1 ITGB2 ICAM1
2 cell adhesion molecule binding GO:0050839 8.8 VCAM1 ITGB2 ITGA4

Sources for Mooren's Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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