Aliases & Classifications for Mooren's Ulcer

MalaCards integrated aliases for Mooren's Ulcer:

Name: Mooren's Ulcer 12 15 73
Moorens Ulcer 55
Mooren Ulcer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10439
ICD10 33 H16.05
ICD9CM 35 370.07
SNOMED-CT 68 22440001
UMLS 73 C0155072

Summaries for Mooren's Ulcer

MalaCards based summary : Mooren's Ulcer, also known as moorens ulcer, is related to cortical thymoma and immune-complex glomerulonephritis. An important gene associated with Mooren's Ulcer is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are cellular and cardiovascular system

Related Diseases for Mooren's Ulcer

Diseases related to Mooren's Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 cortical thymoma 10.4 ICAM1 VCAM1
2 immune-complex glomerulonephritis 10.4 ICAM1 VCAM1
3 limbal stem cell deficiency 10.4 ICAM1 VCAM1
4 henoch-schoenlein purpura 10.4 ICAM1 VCAM1
5 arteriosclerosis obliterans 10.3 ICAM1 VCAM1
6 crescentic glomerulonephritis 10.3 ICAM1 VCAM1
7 dengue disease 10.3 ICAM1 VCAM1
8 oral lichen planus 10.3 ICAM1 VCAM1
9 primary progressive multiple sclerosis 10.3 ICAM1 VCAM1
10 microvascular complications of diabetes 1 10.2 ICAM1 VCAM1
11 heterophyiasis 10.2 ICAM1 SELE
12 plummer's disease 10.2 ICAM1 SELE
13 hymenolepiasis 10.2 ICAM1 SELE
14 endophthalmitis 10.2 ICAM1 SELE
15 hypersensitivity reaction type iii disease 10.2 ICAM1 SELE
16 conjunctivitis 10.2 ICAM1 NLRP3
17 microvascular complications of diabetes 5 10.2 ICAM1 VCAM1
18 plasmodium vivax malaria 10.1 ICAM1 SELE
19 cutaneous lupus erythematosus 10.1 ICAM1 SELE
20 hydrocele 10.1 ITGA4 SELE
21 trypanosomiasis 10.0 ICAM1 VCAM1
22 allergic contact dermatitis 10.0 ICAM1 SELE
23 contact dermatitis 10.0 ICAM1 SELE
24 annular erythema 10.0 ICAM1 ITGB2
25 plasmodium falciparum malaria 10.0 ICAM1 SELE
26 takayasu arteritis 9.9 SELE VCAM1
27 peripheral vascular disease 9.9 SELE VCAM1
28 coronary restenosis 9.8 ITGA4 ITGB2
29 neutrophil migration 9.8 ICAM1 ITGB2
30 chronic venous insufficiency 9.8 ICAM1 ITGA4 VCAM1
31 venous insufficiency 9.8 ICAM1 ITGA4 VCAM1
32 demyelinating disease 9.8 ICAM1 ITGA4
33 pyoderma gangrenosum 9.8 ITGB2 NLRP3
34 urticaria 9.8 NLRP3 SELE
35 lymphocytic vasculitis 9.7 ICAM1 SELE VCAM1
36 scleritis 9.7 ITGB2 SELE
37 subendocardial myocardial infarction 9.7 ICAM1 SELE VCAM1
38 rheumatoid vasculitis 9.7 ICAM1 SELE VCAM1
39 leukostasis 9.7 ICAM1 SELE VCAM1
40 shwartzman phenomenon 9.7 ICAM1 SELE VCAM1
41 cytomegalovirus infection 9.7 ICAM1 SELE VCAM1
42 autoinflammation, lipodystrophy, and dermatosis syndrome 9.7 ICAM1 SELE VCAM1
43 synovitis 9.7 ICAM1 SELE VCAM1
44 arteries, anomalies of 9.7 ICAM1 SELE VCAM1
45 vasculitis 9.7 ICAM1 SELE VCAM1
46 atherosclerosis susceptibility 9.7 ICAM1 SELE VCAM1
47 arteriosclerosis 9.7 ICAM1 SELE VCAM1
48 cerebrovascular disease 9.7 ICAM1 SELE VCAM1
49 leukocyte adhesion deficiency, type i 9.7 ITGB2 SELE
50 pustulosis palmaris et plantaris 9.7 ITGB2 SELE

Graphical network of the top 20 diseases related to Mooren's Ulcer:



Diseases related to Mooren's Ulcer

Symptoms & Phenotypes for Mooren's Ulcer

MGI Mouse Phenotypes related to Mooren's Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 SELE VCAM1 ICAM1 ITGA4 ITGB2 NLRP3
2 cardiovascular system MP:0005385 9.72 SELE VCAM1 ICAM1 ITGA4 ITGB2
3 hematopoietic system MP:0005397 9.63 VCAM1 ICAM1 ITGA4 ITGB2 NLRP3 SELE
4 immune system MP:0005387 9.43 SELE VCAM1 ICAM1 ITGA4 ITGB2 NLRP3
5 mortality/aging MP:0010768 9.1 SELE VCAM1 ICAM1 ITGA4 ITGB2 NLRP3

Drugs & Therapeutics for Mooren's Ulcer

Drugs for Mooren's Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Immunoglobulins Phase 1
3 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
2 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases Enrolling by invitation NCT00357071

Search NIH Clinical Center for Mooren's Ulcer

Genetic Tests for Mooren's Ulcer

Anatomical Context for Mooren's Ulcer

MalaCards organs/tissues related to Mooren's Ulcer:

41
Eye, Bone

Publications for Mooren's Ulcer

Articles related to Mooren's Ulcer:

(show top 50) (show all 118)
# Title Authors Year
1
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer. ( 28716777 )
2017
2
Unusual Case of Acute Corneal Hydrops in Mooren's Ulcer Treated with Intracameral Injection of Perfluoropropane. ( 28936057 )
2017
3
Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer. ( 28740737 )
2017
4
Upregulation of NLRP3 inflammasome components in Mooren's ulcer. ( 27796668 )
2016
5
Mooren's ulcer: 30 years of follow-up. ( 26897333 )
2016
6
Bilateral Mooren's ulcer - Customised corneal graft with additional amniotic membrane graft. ( 26155087 )
2015
7
Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. ( 26180482 )
2015
8
Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. ( 25563762 )
2015
9
Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. ( 26553919 )
2015
10
Pyoderma gangrenosum with corneal perforation by Mooren's ulcer. ( 24801929 )
2014
11
Mooren's ulcer of the cornea after immune reconstitution. ( 24413266 )
2014
12
Mooren's Ulcer in a Cornea Referral Practice in Korea. ( 24960371 )
2014
13
Interventions for Mooren's ulcer. ( 24452998 )
2014
14
Mooren'S ulcer in ibadan, southwest Nigeria. ( 25717466 )
2013
15
Immunosuppression for Mooren's ulcer: evaluation of the stepladder approach--topical, oral and intravenous immunosuppressive agents. ( 23536419 )
2013
16
Use of amniotic membrane and autologous serum eye drops in Mooren's ulcer. ( 23584659 )
2013
17
Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. ( 24345289 )
2013
18
Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. ( 23292924 )
2013
19
Bilateral Mooren's ulcer in a child secondary to helminthic infestation of the gastrointestinal tract. ( 22661075 )
2012
20
Mooren's ulcer in children. ( 22426948 )
2012
21
Mooren's ulcer or peripheral ulcerative keratitis. ( 22556390 )
2012
22
Boston type 1 keratoprosthesis for severe blinding vernal keratoconjunctivitis and Mooren's ulcer. ( 21424885 )
2011
23
Amniotic membrane transplantation for Mooren's ulcer. ( 21176038 )
2011
24
Mooren's ulcer and amniotic membrane transplant: a simple surgical solution? ( 21749593 )
2011
25
Interventions for Mooren's ulcer. ( 21678352 )
2011
26
The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in Mooren's ulcer. ( 21666242 )
2011
27
Adalimumab for Mooren's ulcer. ( 19651317 )
2009
28
Corneoscleral graft in Mooren's ulcer: a case report. ( 19946490 )
2009
29
Chronic hepatitis C virus infection is not associated with Mooren's ulcer. ( 17618247 )
2008
30
HLA-DR17 and Mooren's ulcer in South India. ( 18211934 )
2008
31
Autologous serum application in the treatment of Mooren's ulcer. ( 17458797 )
2007
32
Treatment of Mooren's ulcer with topical administration of interferon alfa 2a. ( 17198731 )
2007
33
Clinical characteristics of Mooren's ulcer in South India. ( 17035269 )
2007
34
Hookworm infestation as a risk factor for Mooren's ulcer in South India. ( 17123614 )
2007
35
Favourable response to infliximab in a case of bilateral refractory Mooren's ulcer. ( 18173422 )
2007
36
The involvement of multipotential progenitor cells in Mooren's ulcer. ( 15988806 )
2005
37
Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren's ulcer: a case report. ( 15812773 )
2005
38
A case of Mooren's ulcer associated with a pterygium. ( 16365810 )
2005
39
Cataract surgery in patients with Mooren's ulcer. ( 15767159 )
2005
40
Bilateral Mooren's ulcer in six patients: diagnosis, surgery and histopathology. ( 15085968 )
2004
41
Bone marrow-derived cells are present in Mooren's ulcer. ( 15103206 )
2004
42
Relapsing Mooren's ulcer after amniotic membrane transplantation combined with conjunctival autografting. ( 15051214 )
2004
43
Mooren's ulcer resolved with campath-1H. ( 12812907 )
2003
44
Association of HLA type and Mooren's Ulcer in Chinese in Taiwan. ( 12770994 )
2003
45
Fresh amniotic membrane transplantation combined lamellar keratoplasty for patients with recurrent Mooren's ulcer. ( 12852079 )
2003
46
Cataract surgery in patients with advanced Mooren's ulcer. ( 11583681 )
2001
47
Microsurgical treatment of Mooren's ulcer. ( 12579731 )
2000
48
Mooren's ulcer in China: a study of clinical characteristics and treatment. ( 11049948 )
2000
49
[A histochemical and immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer]. ( 12579925 )
2000
50
Mooren's ulcer. ( 10081726 )
1998

Variations for Mooren's Ulcer

Expression for Mooren's Ulcer

Search GEO for disease gene expression data for Mooren's Ulcer.

Pathways for Mooren's Ulcer

Pathways related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 ICAM1 ITGA4 ITGB2 VCAM1
2
Show member pathways
13.06 ICAM1 ITGA4 ITGB2 VCAM1
3
Show member pathways
12.48 ICAM1 ITGA4 ITGB2 VCAM1
4
Show member pathways
12.38 ICAM1 ITGA4 ITGB2 VCAM1
5 12.18 ICAM1 ITGB2 VCAM1
6
Show member pathways
12.15 ICAM1 SELE VCAM1
7
Show member pathways
12 ITGA4 ITGB2 SELE
8 11.88 ICAM1 SELE VCAM1
9
Show member pathways
11.85 ICAM1 ITGA4 ITGB2 VCAM1
10 11.78 ICAM1 ITGB2 VCAM1
11 11.75 ICAM1 SELE VCAM1
12 11.75 ICAM1 ITGA4 ITGB2 VCAM1
13 11.68 ICAM1 SELE VCAM1
14 11.65 ICAM1 ITGA4 ITGB2 VCAM1
15 11.62 ICAM1 VCAM1
16 11.6 ICAM1 ITGB2
17 11.56 ITGA4 ITGB2
18 11.54 ICAM1 SELE
19 11.5 ITGB2 NLRP3
20
Show member pathways
11.45 ICAM1 SELE VCAM1
21 11.36 ICAM1 ITGB2
22 11.29 ICAM1 ITGB2
23 11.29 ICAM1 SELE VCAM1
24
Show member pathways
11.25 ITGA4 ITGB2 VCAM1
25 11.18 ICAM1 ITGA4 ITGB2 SELE VCAM1
26 11.15 ICAM1 ITGB2 SELE VCAM1
27 11.12 ICAM1 SELE VCAM1
28 10.98 ICAM1 NLRP3
29 10.9 ICAM1 ITGA4 ITGB2 VCAM1
30 10.77 ICAM1 VCAM1

GO Terms for Mooren's Ulcer

Cellular components related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.43 ICAM1 ITGB2 VCAM1
2 integrin complex GO:0008305 9.16 ITGA4 ITGB2
3 membrane raft GO:0045121 9.13 ICAM1 ITGB2 SELE
4 cell surface GO:0009986 8.92 ICAM1 ITGA4 ITGB2 VCAM1

Biological processes related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.77 ITGB2 NLRP3 SELE
2 cytokine-mediated signaling pathway GO:0019221 9.74 ICAM1 ITGB2 VCAM1
3 response to lipopolysaccharide GO:0032496 9.7 ICAM1 SELE VCAM1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.69 ICAM1 ITGB2 NLRP3
5 cell-cell adhesion GO:0098609 9.67 ICAM1 ITGB2 VCAM1
6 regulation of immune response GO:0050776 9.67 ICAM1 ITGA4 ITGB2 VCAM1
7 cell-matrix adhesion GO:0007160 9.63 ITGA4 ITGB2 VCAM1
8 integrin-mediated signaling pathway GO:0007229 9.62 ITGA4 ITGB2
9 leukocyte migration GO:0050900 9.62 ICAM1 ITGA4 ITGB2 SELE
10 regulation of inflammatory response GO:0050727 9.61 NLRP3 SELE
11 B cell differentiation GO:0030183 9.61 ITGA4 VCAM1
12 interferon-gamma-mediated signaling pathway GO:0060333 9.6 ICAM1 VCAM1
13 response to ionizing radiation GO:0010212 9.58 ICAM1 VCAM1
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ICAM1 ITGB2
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELE VCAM1
16 endodermal cell differentiation GO:0035987 9.56 ITGA4 ITGB2
17 extracellular matrix organization GO:0030198 9.56 ICAM1 ITGA4 ITGB2 VCAM1
18 receptor clustering GO:0043113 9.55 ITGA4 ITGB2
19 cell adhesion GO:0007155 9.55 ICAM1 ITGA4 ITGB2 SELE VCAM1
20 heterotypic cell-cell adhesion GO:0034113 9.54 ITGA4 ITGB2
21 leukocyte migration involved in inflammatory response GO:0002523 9.48 ITGB2 SELE
22 membrane to membrane docking GO:0022614 9.43 ICAM1 VCAM1
23 leukocyte tethering or rolling GO:0050901 9.13 ITGA4 SELE VCAM1
24 leukocyte cell-cell adhesion GO:0007159 9.02 ICAM1 ITGA4 ITGB2 SELE VCAM1

Molecular functions related to Mooren's Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.8 ITGA4 ITGB2 VCAM1

Sources for Mooren's Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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45 MESH via Orphanet
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54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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