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MCID: MRN002
MIFTS: 32

Mooren's Ulcer

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Mooren's Ulcer

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MalaCards integrated aliases for Mooren's Ulcer:

Name: Mooren's Ulcer 12 15 71
Mooren Ulcer 12 58
Moorens Ulcer 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:10439
ICD9CM 34 370.07
SNOMED-CT 67 22440001
ICD10 32 H16.05
Orphanet 58 ORPHA519408
UMLS 71 C0155072
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Summaries for Mooren's Ulcer

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Disease Ontology : 12 A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema.

MalaCards based summary : Mooren's Ulcer, also known as mooren ulcer, is related to gastrointestinal ulceration, recurrent, with dysfunctional platelets and corneal ulcer. An important gene associated with Mooren's Ulcer is S100A12 (S100 Calcium Binding Protein A12), and among its related pathways/superpathways are Innate Immune System and Measles. Affiliated tissues include eye and bone marrow, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Mooren's Ulcer

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Diseases related to Mooren's Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal ulceration, recurrent, with dysfunctional platelets 11.0
2 corneal ulcer 10.5
3 keratitis, hereditary 10.4
4 cataract 10.3
5 autoimmune enteropathy 10.2 ITGAL ICAM1
6 venous insufficiency 10.2 VCAM1 ICAM1
7 macular degeneration, age-related, 9 10.2 VCAM1 ICAM1
8 rheumatoid vasculitis 10.2 VCAM1 ICAM1
9 shwartzman phenomenon 10.2 VCAM1 ICAM1
10 limbal stem cell deficiency 10.2 VCAM1 ICAM1
11 buerger disease 10.2 VCAM1 ICAM1
12 post-thrombotic syndrome 10.2 VCAM1 ICAM1
13 keshan disease 10.2 VCAM1 ICAM1
14 hepatitis c 10.2
15 sympathetic ophthalmia 10.2 VCAM1 ICAM1
16 oral lichen planus 10.2 VCAM1 ICAM1
17 henoch-schoenlein purpura 10.2 VCAM1 ICAM1
18 familial cold autoinflammatory syndrome 1 10.1 NLRP3 NLRP13
19 autoimmune disease 10.1
20 corneal disease 10.1
21 corneal edema 10.1
22 blind hypotensive eye 10.1
23 corneal degeneration 10.1
24 scleritis 10.1
25 eye disease 10.1
26 arteriosclerosis obliterans 10.1 VCAM1 ICAM1
27 leukostasis 10.1 VCAM1 ICAM1
28 plasmodium vivax malaria 10.1 VCAM1 ICAM1
29 blau syndrome 10.1 S100A12 NLRP3
30 erythema nodosum 10.1 VCAM1 ICAM1
31 polyarteritis nodosa 10.1 VCAM1 ICAM1
32 proteasome-associated autoinflammatory syndrome 1 10.1 VCAM1 NLRP3 ICAM1
33 crescentic glomerulonephritis 10.0 VCAM1 ICAM1
34 actinic prurigo 10.0 VCAM1 ITGAL ICAM1
35 immune-complex glomerulonephritis 10.0 VCAM1 ITGAL ICAM1
36 glomerulonephritis 10.0 VCAM1 ITGAL ICAM1
37 chronic venous insufficiency 10.0 VCAM1 ITGAL ICAM1
38 primary progressive multiple sclerosis 10.0 VCAM1 ITGAL ICAM1
39 atherosclerosis susceptibility 10.0 VCAM1 NLRP3 ICAM1
40 crohn's disease 10.0 S100A12 NLRP3 ICAM1
41 microvascular complications of diabetes 1 10.0
42 microvascular complications of diabetes 2 10.0
43 microvascular complications of diabetes 5 10.0
44 keratoconus 10.0
45 corneal neovascularization 10.0
46 regular astigmatism 10.0
47 irregular astigmatism 10.0
48 herpes simplex 10.0
49 leukocyte adhesion deficiency, type i 10.0 VCAM1 ITGAL ICAM1
50 takayasu arteritis 10.0 VCAM1 S100A12 ICAM1

Graphical network of the top 20 diseases related to Mooren's Ulcer:



Diseases related to Mooren's Ulcer
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Symptoms & Phenotypes for Mooren's Ulcer

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MGI Mouse Phenotypes related to Mooren's Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD8A ICAM1 ITGAL NLRP3 NLRX1 SUCNR1
2 immune system MP:0005387 9.23 CD8A ICAM1 ITGAL NLRP3 NLRX1 SUCNR1
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Drugs & Therapeutics for Mooren's Ulcer

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Search Clinical Trials , NIH Clinical Center for Mooren's Ulcer

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Genetic Tests for Mooren's Ulcer

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Anatomical Context for Mooren's Ulcer

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MalaCards organs/tissues related to Mooren's Ulcer:

40
Eye, Bone Marrow
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Publications for Mooren's Ulcer

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Articles related to Mooren's Ulcer:

(show top 50) (show all 252)
# Title Authors PMID Year
1
Mooren ulcer: an immunopathologic study. 54 61
17077658 2006
2
[A histochemical and immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer]. 61 54
12579925 2000
3
Cytokine-induced calgranulin C expression in keratocytes. 61 54
10219252 1999
4
Cloning and expression of human corneal calgranulin C (CO-Ag). 54 61
9746433 1998
5
Cloning and sequence analysis of human and bovine corneal antigen (CO-Ag) cDNA: identification of host-parasite protein calgranulin C. 61 54
9440166 1997
6
Treating Mooren's Ulcer - Squeezing Water From a Stone. 61
33505815 2020
7
Acellular Porcine Corneal Stroma May Not Be Optimal for Peripheral Keratoplasty: Reports of 2 Cases. 61
33252383 2020
8
Large-diameter Deep Anterior Lamel-lar Keratoplasty: An Alternative Treatment for Mooren Ulcer. 61
33099564 2020
9
Comparative Study on the Efficacy of Frozen Amniotic Membrane Transplantation and Lamellar Keratoplasty in the Treatment of Mooren Ulcer. 61
32947342 2020
10
Techniques of noncircular corneal transplantation. 61
32412959 2020
11
Comment on Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer. 61
32551901 2020
12
Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer. 61
32141311 2020
13
Case of bilateral Mooren's ulcers following filtering surgery using EX-PRESS glaucoma filtering devices. 61
31956729 2020
14
[Mooren's ulcer]. 61
33063972 2020
15
Interferon Alpha 2a and 2b in Ophthalmology: A Review. 61
30950678 2019
16
Terrien marginal degeneration. 61
30316804 2019
17
[Clinical features, treatment distribution and outcomes of Mooren's ulcer]. 61
30772992 2019
18
Aggressive Mooren's Ulcer and challenges in its management: Tale of three patients in pictures. 61
30930676 2019
19
Mooren Ulcer in a Child Wearing Orthokeratology Contact Lenses. 61
27755290 2018
20
Etiology and failure analysis of anterior lamellar keratoplasty. 61
29862176 2018
21
Cataract surgery in ocular surface diseases: clinical challenges and outcomes. 61
29210839 2018
22
Various therapies for ocular surface diseases. 61
29796439 2018
23
Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer. 61
30450301 2018
24
Case report: bilateral Mooren ulcer in association with hepatitis C. 61
29212473 2017
25
Clinical course and outcomes in patients with Mooren ulcer who had cataract surgery. 61
28917404 2017
26
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer. 61
28716777 2017
27
Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases. 61
28619029 2017
28
Management of severe and refractory Mooren's ulcers with rituximab. 61
27450147 2017
29
Unusual Case of Acute Corneal Hydrops in Mooren's Ulcer Treated with Intracameral Injection of Perfluoropropane. 61
28936057 2017
30
Upregulation of NLRP3 inflammasome components in Mooren's ulcer. 61
27796668 2017
31
Clinical Characteristics and Risk Factors of Recurrent Mooren's Ulcer. 61
28740737 2017
32
Efficacy of conjunctival resection with cyanoacrylate glue application in preventing recurrences of Mooren's ulcer. 61
26553919 2016
33
Mooren's ulcer: 30 years of follow-up. 61
26897333 2016
34
Mooren's Ulcer in a Cornea Referral Practice in Korea. 61
24960371 2016
35
Demographic profile, clinical features and outcome of peripheral ulcerative keratitis: a prospective study. 61
25935428 2015
36
Ophthalmological implications of the chronic infections with the hepatitis C Virus. 61
29450318 2015
37
Interplay of Immune Cells in Mooren Ulcer. 61
25970436 2015
38
Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer. 61
26180482 2015
39
Bilateral Mooren's ulcer - Customised corneal graft with additional amniotic membrane graft. 61
26155087 2015
40
Modified lamellar keratoplasty and immunosuppressive therapy guided by in vivo confocal microscopy for perforated Mooren's ulcer. 61
25563762 2015
41
Deep anterior lamellar keratoplasty using irradiated acellular cornea with amniotic membrane transplantation for intractable ocular surface diseases. 61
25829823 2015
42
Corneal topographic analysis of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography. 61
25162758 2015
43
[Peripheral ulcerative keratitis in a 24-year-old patient]. 61
24046173 2014
44
Partial lamellar keratoplasty for peripheral corneal disease using a graft from the glycerin-preserved corneoscleral rim. 61
24796771 2014
45
Age distribution of various corneal diseases in China by histopathological examination of 3112 surgical specimens. 61
24722694 2014
46
Pyoderma gangrenosum with corneal perforation by Mooren's ulcer. 61
24801929 2014
47
Mooren's ulcer of the cornea after immune reconstitution. 61
24413266 2014
48
Interventions for Mooren's ulcer. 61
24452998 2014
49
Amniotic membrane transplantation ineffective as additional therapy in patients with aggressive Mooren's ulcer. 61
24345289 2013
50
Peripheral ulcerative keratitis in association with sarcoidosis. 61
23993305 2013
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Variations for Mooren's Ulcer

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Expression for Mooren's Ulcer

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Search GEO for disease gene expression data for Mooren's Ulcer.
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Pathways for Mooren's Ulcer

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Pathways related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.63 VCAM1 S100A12 NLRX1 NLRP3 ITGAL ICAM1
2
Measles 36
Show member pathways
 12.44 NLRX1 NLRP3 ITGAL ICAM1
3
ECM-receptor interaction 36
Show member pathways
 11.77 VCAM1 ITGAL ICAM1
4
Cell adhesion molecules 36
11.43 VCAM1 ITGAL ICAM1 CD8A
5
IgA-Producing B Cells in the Intestine 64
11.32 VCAM1 ITGAL ICAM1
6
Thromboxane A2 receptor signaling 1
11.18 VCAM1 ICAM1
7
Paxillin-dependent events mediated by a4b1 1
Show member pathways
 11.15 VCAM1 ITGAL
8
Malaria 36
11.13 VCAM1 ITGAL ICAM1
9
African trypanosomiasis 36
11.05 VCAM1 ICAM1
10
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
11.05 VCAM1 ITGAL ICAM1 CD8A
11
Immune response_Role of integrins in NK cells cytotoxicity 23
10.98 VCAM1 ITGAL ICAM1
12
IL1 and megakaryocytes in obesity 1
10.85 NLRP3 ICAM1
13
LDL Oxidation in Atherogenesis 63
10.57 VCAM1 ICAM1
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GO Terms for Mooren's Ulcer

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Biological processes related to Mooren's Ulcer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.81 S100A12 NLRX1 NLRP3 CD8A
2 cell adhesion GO:0007155 9.76 VCAM1 TOR1A ITGAL ICAM1
3 extracellular matrix organization GO:0030198 9.65 VCAM1 ITGAL ICAM1
4 cell-cell adhesion GO:0098609 9.61 VCAM1 ITGAL ICAM1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 S100A12 NLRP3 ICAM1
6 response to ethanol GO:0045471 9.54 VCAM1 NLRP3 ICAM1
7 response to ionizing radiation GO:0010212 9.52 VCAM1 ICAM1
8 cellular response to amyloid-beta GO:1904646 9.49 VCAM1 ICAM1
9 regulation of immune response GO:0050776 9.46 VCAM1 ITGAL ICAM1 CD8A
10 membrane to membrane docking GO:0022614 9.32 VCAM1 ICAM1
11 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.26 ITGAL ICAM1
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.13 VCAM1 ITGAL ICAM1
13 leukocyte cell-cell adhesion GO:0007159 8.8 VCAM1 ITGAL ICAM1
Sources

Sources for Mooren's Ulcer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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