MCID: MRG001
MIFTS: 24

Morgagni Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Morgagni Cataract

MalaCards integrated aliases for Morgagni Cataract:

Name: Morgagni Cataract 12 15
Hypermature Cataract 12
Morgagnian Cataract 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13964
ICD9CM 35 366.18
SNOMED-CT 68 22315007
UMLS 72 C0152258

Summaries for Morgagni Cataract

Disease Ontology : 12 A senile cataract that is characterized by dense white opacification of the lens and milky fluid in the lens capsule such that the dense nucleus of the lens sinks in the surrounding fluid. It is the late stage of senile cataracts and is caused by a multifactorial etiology related to aging.

MalaCards based summary : Morgagni Cataract, also known as hypermature cataract, is related to vitreous disease and intraocular pressure quantitative trait locus. An important gene associated with Morgagni Cataract is PEX19 (Peroxisomal Biogenesis Factor 19), and among its related pathways/superpathways are NRF2 pathway and Cell adhesion_Plasmin signaling. Affiliated tissues include eye.

Related Diseases for Morgagni Cataract

Diseases related to Morgagni Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 vitreous disease 30.5 TGFB2 FGF2
2 intraocular pressure quantitative trait locus 10.6
3 corneal edema 10.5
4 phacolytic glaucoma 10.5
5 uveitis 10.4
6 cataract 10.2
7 anterior horn cell disease 10.2 HHEX FUS
8 angiomatous meningioma 10.2 GAPDH FGF2
9 melanoma, uveal 10.2
10 astigmatism 10.2
11 pars planitis 10.2
12 hypopyon 10.2
13 mature cataract 10.2
14 senile cataract 10.2
15 phacoanaphylactic uveitis 10.2
16 osteochondroma 10.1 TGFB2 FGF2
17 connective tissue cancer 10.0 FUS FGF2
18 pancreatic cystadenocarcinoma 9.9 TXN GLRX
19 vitreoretinopathy, neovascular inflammatory 9.8 TGFB2 FGF2

Comorbidity relations with Morgagni Cataract via Phenotypic Disease Network (PDN):


Phacolytic Glaucoma

Graphical network of the top 20 diseases related to Morgagni Cataract:



Diseases related to Morgagni Cataract

Symptoms & Phenotypes for Morgagni Cataract

Drugs & Therapeutics for Morgagni Cataract

Search Clinical Trials , NIH Clinical Center for Morgagni Cataract

Genetic Tests for Morgagni Cataract

Anatomical Context for Morgagni Cataract

MalaCards organs/tissues related to Morgagni Cataract:

41
Eye

Publications for Morgagni Cataract

Articles related to Morgagni Cataract:

(show all 30)
# Title Authors PMID Year
1
Morgagnian Cataract. 38
31392333 2019
2
Acute Phacolytic Glaucoma and Morgagnian Cataract. 38
30973585 2019
3
Femtosecond laser-assisted cataract surgery for the white cataract. 38
29907631 2019
4
Multimodal imaging in an idiopathic spontaneously absorbed cataractous lens: A rare case report. 38
30841756 2019
5
"Triangle sign" in Morgagnian cataract. 38
30574920 2019
6
Zepto-rhexis: A new surgical technique of capsulorhexis using precision nano-pulse technology in difficult cataract cases. 38
30038166 2018
7
[Morgagnian cataract]. 38
29515742 2017
8
Intraocular lens scaffold technique to prevent posterior capsule rupture in cases of Morgagnian cataract. 38
28317682 2017
9
Morgagnian cataract resulting from a naturally occurring nonsense mutation elucidates a role of CPAMD8 in mammalian lens development. 38
28683140 2017
10
[Post-traumatic Morgagnian cataract]. 38
26987897 2016
11
Images in clinical medicine. Morgagnian cataract. 38
24918375 2014
12
[Sunset (Morgagnian) cataract]. 38
22464866 2012
13
Non-Invasive Couching Technique to Treat a Morgagnian Cataract Causing Bullous Keratopathy. 38
20438042 2010
14
Visco-shell technique with sodium hyaluronate 2.3% in phacoemulsification of Morgagnian cataract. 38
19006724 2008
15
Morgagnian cataract with an isolated posterior capsular opening. 38
14557192 2003
16
Phacofragmentation for morgagnian cataract in a horse. 38
11722788 2001
17
Na,K-ATPase in lens epithelia from patients with senile cataracts. 38
10560239 1999
18
The Morgagnian and Brunescens cataract morphology studied with with SEM and TEM. 38
8398567 1993
19
Study of the substructure of the Morgagni and Brunescens cataract with the TAO non-coating technique. Part 1: Morgagni cataract. 38
1305020 1992
20
Study of the substructure of the Morgagni and Brunescens cataract with the TAO non-coating technique. Part 2: Brunescens cataract. 38
1305021 1992
21
Acidic lens-protein-degrading activity in aqueous humour. 38
3758213 1986
22
[Double refraction of crystals in the lens (spheroliths, "Christmas tree ornaments") and in the vitreous body (scintillatio nivea)]. 38
7160640 1982
23
["Spontaneous healing" of hypermature Morgagnian cataract: case report with photographs (author's transl)]. 38
7421056 1980
24
Unilateral Morgagnian cataract. 38
893943 1977
25
Morgagnian cataract. 38
1070881 1976
26
A modified erisophake. Extraction of a hypermature (Morgagni) cataract. 38
13903577 1962
27
[Overripe Morgagni cataract and its complications]. 38
14038798 1962
28
The morgagnian cataract: its characteristics and surgery. 38
14388100 1955
29
[Phacogenetic ophthalmia in morgagnian cataract; clinical and histological observations on two cases of hypermature cataract with spontaneous capsular defects with contralateral aphakia]. 38
13131740 1953
30
Observations on Glaucoma in Morgagnian Cataract. 38
16692750 1926

Variations for Morgagni Cataract

Expression for Morgagni Cataract

Search GEO for disease gene expression data for Morgagni Cataract.

Pathways for Morgagni Cataract

Pathways related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 TXN TGFB2 GSR
2 10.85 TGFB2 FGF2
3 10.2 TXN GSR GLRX

GO Terms for Morgagni Cataract

Cellular components related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.28 TXN RNF8 PEX19 LAX1 GSR GMDS

Biological processes related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell division GO:0051781 9.16 TGFB2 FGF2
2 nucleobase-containing small molecule interconversion GO:0015949 8.96 GSR GLRX
3 cell redox homeostasis GO:0045454 8.8 TXN GSR GLRX

Molecular functions related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 GSR GAPDH
2 protein disulfide oxidoreductase activity GO:0015035 8.62 TXN GLRX

Sources for Morgagni Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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