MCID: MRG001
MIFTS: 26

Morgagni Cataract

Categories: Eye diseases, Genetic diseases

Aliases & Classifications for Morgagni Cataract

MalaCards integrated aliases for Morgagni Cataract:

Name: Morgagni Cataract 12 15
Hypermature Cataract 12
Morgagnian Cataract 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13964
ICD9CM 36 366.18
SNOMED-CT 69 22315007
UMLS 74 C0152258

Summaries for Morgagni Cataract

MalaCards based summary : Morgagni Cataract, also known as hypermature cataract, is related to phacolytic glaucoma and phacogenic glaucoma. An important gene associated with Morgagni Cataract is GMDS (GDP-Mannose 4,6-Dehydratase), and among its related pathways/superpathways are NRF2 pathway and Detoxification of Reactive Oxygen Species. Affiliated tissues include eye and cortex.

Related Diseases for Morgagni Cataract

Diseases related to Morgagni Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 phacolytic glaucoma 10.3
2 phacogenic glaucoma 10.2 PEX19 PHEX
3 chronic closed-angle glaucoma 10.2 PHEX TGFB2
4 iris disease 10.2 PEX19 PHEX
5 uveitis 10.2
6 phacoanaphylactic uveitis 10.2
7 cataract 10.1
8 juvenile glaucoma 10.1 PHEX TGFB2
9 lens disease 10.1 PEX19 PHEX
10 anterior horn cell disease 10.1 FUS HHEX
11 uveal disease 10.0 PEX19 PHEX
12 pancreatic cystadenocarcinoma 9.9 GLRX TXN

Comorbidity relations with Morgagni Cataract via Phenotypic Disease Network (PDN):


Phacolytic Glaucoma

Graphical network of the top 20 diseases related to Morgagni Cataract:



Diseases related to Morgagni Cataract

Symptoms & Phenotypes for Morgagni Cataract

Drugs & Therapeutics for Morgagni Cataract

Search Clinical Trials , NIH Clinical Center for Morgagni Cataract

Genetic Tests for Morgagni Cataract

Anatomical Context for Morgagni Cataract

MalaCards organs/tissues related to Morgagni Cataract:

42
Eye, Cortex

Publications for Morgagni Cataract

Articles related to Morgagni Cataract:

(show all 22)
# Title Authors Year
1
Comment on "A case of hypermature cataract formation following implantation of an implantable collamer lens with an Aquaport". ( 30662860 )
2019
2
A case of hypermature cataract formation following implantation of an implantable collamer lens with an Aquaport. ( 28730098 )
2017
3
Impact of lens thickness on complications of hypermature cataract surgery: A prospective study. ( 27553178 )
2016
4
Spontaneous rupture of the lens capsule in hypermature cataract: presentations and outcomes. ( 26567023 )
2016
5
Intraocular pressure, specular microscopy, and prostaglandin E2 concentration in dogs with mature and hypermature cataract. ( 24450881 )
2014
6
Spontaneous rupture of lens capsule with dislocation of nucleus in hypermature cataract. ( 25341832 )
2014
7
Ciliary body and choroidal pseudomelanoma from ultrasonographic imaging of hypermature cataract in 20 cases. ( 23916484 )
2013
8
Continuous curvilinear capsulorhexis in intumescent or hypermature cataract with liquefied cortex. ( 12663001 )
2003
9
Phacoemulsification of white hypermature cataract. ( 10445205 )
1999
10
Fluorescein blue, light-assisted capsulorhexis for mature or hypermature cataract. ( 9494894 )
1998
11
Study of the substructure of the Morgagni and Brunescens cataract with the TAO non-coating technique. Part 1: Morgagni cataract. ( 1305020 )
1992
12
Complications of hypermature cataract: spontaneous absorption of lens material and phacolytic glaucoma-associated retinal perivasculitis. ( 3411811 )
1988
13
Hypermature cataract in a crested mynah, Leucopsar rothschildi. ( 6887443 )
1983
14
Dehydration of the crystalline lens: a possible means of extracting the hypermature cataract. ( 5068226 )
1972
15
GLAUCOMA DUE TO HYPERMATURE CATARACT: THE USE OF UREA IN DIAGNOSIS. ( 14045352 )
1963
16
A modified erisophake. Extraction of a hypermature (Morgagni) cataract. ( 13903577 )
1962
17
The hypermature cataract. ( 13691280 )
1960
18
Completely Dislocated Hypermature Cataract and Glaucoma. ( 16693572 )
1959
19
Complications and treatment of the hypermature cataract. ( 13635719 )
1958
20
Complications & treatment of hypermature cataract. ( 13635721 )
1958
21
Phacolytic glaucoma; a clinicopathologic study of one hundred thirty-eight cases of glaucoma associated with hypermature cataract. ( 14375459 )
1955
22
Lens-induced uveitis and glaucoma. III. "Phacogenetic glaucoma": lens-induced glaucoma; mature or hypermature cataract; open iridocorneal angle. ( 14914837 )
1952

Variations for Morgagni Cataract

Expression for Morgagni Cataract

Search GEO for disease gene expression data for Morgagni Cataract.

Pathways for Morgagni Cataract

Pathways related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 GSR TGFB2 TXN
2
Show member pathways
10.9 GSR TXN
3 10.2 GLRX GSR TXN

GO Terms for Morgagni Cataract

Cellular components related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.32 CALD1 FUS GAPDH GLRX GMDS GSR

Biological processes related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 GAPDH GLRX GSR TXN
2 cell-cell signaling GO:0007267 9.33 PHEX TGFB2 TXN
3 nucleobase-containing small molecule interconversion GO:0015949 8.96 GLRX GSR
4 cell redox homeostasis GO:0045454 8.8 GLRX GSR TXN

Molecular functions related to Morgagni Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 GAPDH GSR
2 protein disulfide oxidoreductase activity GO:0015035 8.62 GLRX TXN

Sources for Morgagni Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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