Aliases & Classifications for Morning Glory Syndrome

MalaCards integrated aliases for Morning Glory Syndrome:

Name: Morning Glory Syndrome 53
Volubilis Syndrome 53
Ectasic Coloboma 53

Classifications:



Summaries for Morning Glory Syndrome

NIH Rare Diseases : 53 Morning glory syndrome (MGS) is a birth (congenital) defect of the nerve of the eye (optic nerve) that resembles a flower known as "morning glory". It is characterized by an enlarged, funnel-shaped cavity of the optic disc, the point in the eye where the optic nerve fibers leave the retina. The disc is enlarged and has a white center (giving the appearance of a white pupil).  The blood vessels are increased in number and curve as they come from the enlarged disc that have the white center, resulting in this malformation to be similar to petals on a flower. Most reported cases are unilateral (affecting only one eye), sporadic (without other cases in the family), and occur in females. Symptoms include very poor vision in the affected eye with poor visual acuity. MGS may occur by itself or along with other eye abnormalities, such as crossed eyes (strabismus) or lazy eye (amblyopia), or other non-ocular problems like brain disorders. It does not appear to be a specific genetic disorder. Typically, individuals with non-ocular  findings also have a wide head, depressed nasal bridge, and mid upper lip defect or cleft. MGS seems to be caused from failure of the optic nerve to completely form when the baby is developing.  The most severe complication is retinal detachment, and can occur in about 26–38% of people with MGS. The MGS is sometimes misdiagnosed as an optic nerve coloboma.  Treatment includes surgery and may result in some recovery of vision.  Depending on the other associated abnormalities some patients require referrals to several specialties such as neurosurgery, interventional neuroradiology, otolaryngology, and dentistry. All people diagnosed with morning glory disc anomaly should have brain image exams. 

MalaCards based summary : Morning Glory Syndrome, also known as volubilis syndrome, is related to coloboma of optic nerve and encephalocele. An important gene associated with Morning Glory Syndrome is GJA3 (Gap Junction Protein Alpha 3). Affiliated tissues include eye, retina and brain, and related phenotypes are strabismus and cataract

Related Diseases for Morning Glory Syndrome

Graphical network of the top 20 diseases related to Morning Glory Syndrome:



Diseases related to Morning Glory Syndrome

Symptoms & Phenotypes for Morning Glory Syndrome

Human phenotypes related to Morning Glory Syndrome:

32 (show all 7)
# Description HPO Frequency HPO Source Accession
1 strabismus 32 hallmark (90%) HP:0000486
2 cataract 32 occasional (7.5%) HP:0000518
3 retinal detachment 32 occasional (7.5%) HP:0000541
4 optic nerve coloboma 32 occasional (7.5%) HP:0000588
5 nystagmus 32 occasional (7.5%) HP:0000639
6 amblyopia 32 hallmark (90%) HP:0000646
7 abnormality of retinal pigmentation 32 hallmark (90%) HP:0007703

MGI Mouse Phenotypes related to Morning Glory Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.62 GJA3 PAX6

Drugs & Therapeutics for Morning Glory Syndrome

Search Clinical Trials , NIH Clinical Center for Morning Glory Syndrome

Genetic Tests for Morning Glory Syndrome

Anatomical Context for Morning Glory Syndrome

MalaCards organs/tissues related to Morning Glory Syndrome:

41
Eye, Retina, Brain, Pituitary, Skin

Publications for Morning Glory Syndrome

Articles related to Morning Glory Syndrome:

(show all 46)
# Title Authors Year
1
INTRAVITREAL AFLIBERCEPT IN THE TREATMENT OF POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH MORNING GLORY SYNDROME. ( 29324624 )
2018
2
MORNING GLORY SYNDROME IN A NIGERIAN - A CASE REPORT. ( 29951459 )
2017
3
[Ultrasound Manifestations of Eyes of Pediatric Patients with Morning Glory Syndrome]. ( 28752984 )
2017
4
A case of morning glory syndrome associated with persistent hyperplastic primary vitreous and Peters' anomaly. ( 28154792 )
2017
5
Intraoperative optical coherence tomography assisted analysis of pars Plana vitrectomy for retinal detachment in morning glory syndrome: a case report. ( 28764684 )
2017
6
Intravitreal ranibizumab in the treatment of choroidal neovascularization secondary to morning glory syndrome in a child. ( 27330395 )
2016
7
Perfluorocarbon liquid migration into the subarachnoid space in a patient with morning glory syndrome. ( 27239578 )
2015
8
Ranibizumab in the treatment of choroidal neovascularization associated with morning glory syndrome. ( 25726749 )
2015
9
Morning Glory Syndrome with Carotid and Middle Cerebral Artery Vasculopathy. ( 26540473 )
2015
10
Patient with Morning Glory syndrome. ( 25993084 )
2015
11
Combined pituitary hormone deficiency with unique pituitary dysplasia and morning glory syndrome related to a heterozygous PROKR2 mutation. ( 25678757 )
2015
12
Morning glory syndrome associated with multiple sclerosis. ( 25422739 )
2014
13
Morning glory syndrome associated with transsphenoidal encephalocele and panhypopituitarism. ( 24418230 )
2014
14
Morning glory syndrome associated with primary open angle glaucoma--case report. ( 24839779 )
2014
15
Swept-source optical coherence tomographic findings in morning glory syndrome. ( 23719401 )
2014
16
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. ( 24404661 )
2013
17
Cryptic Uveitis in a Patient with Morning Glory Syndrome. ( 24143921 )
2013
18
Clinical characteristics and treatment of 22 eyes of morning glory syndrome associated with persistent hyperplastic primary vitreous. ( 23878133 )
2013
19
Retinal detachment associated with optic disc colobomas and morning glory syndrome. ( 22241012 )
2012
20
Morning glory syndrome. ( 23134929 )
2012
21
Fibrin sealant in the treatment of retinal detachment in morning glory syndrome. ( 25390426 )
2011
22
Retinal detachment in morning glory syndrome with large hole in the excavated disc. ( 21607925 )
2011
23
Evaluation of morning glory syndrome with spectral optical coherence tomography and echography. ( 20163868 )
2010
24
Vitrectomy of rhegmatogenous retinal detachment in morning glory syndrome. ( 22553526 )
2010
25
47 XYY and morning glory syndrome--a unique association. ( 19487143 )
2009
26
Endoscopic treatment of trans-sellar trans-sphenoidal encephalocele associated with morning glory syndrome presenting with non-traumatic cerebrospinal fluid rhinorrhea. ( 19322134 )
2009
27
Morning glory syndrome associated with posterior lenticonus. ( 19597560 )
2009
28
Absence of mutations in Pax6 gene in three cases of morning glory syndrome associated with isolated growth hormone deficiency. ( 19169473 )
2008
29
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. ( 18388784 )
2008
30
Basal encephalocele associated with morning glory syndrome: case report. ( 18094860 )
2007
31
Brown syndrome associated with morning glory syndrome. ( 16340505 )
2005
32
Morning glory syndrome and basal encephalocele. ( 14691642 )
2004
33
Morning glory syndrome associated with posterior pituitary ectopia and hypopituitarism. ( 14738491 )
2004
34
[Morning glory syndrome -- a clinical study of two cases]. ( 12494371 )
2002
35
Basal encephaloceles with morning glory syndrome, and progressive hormonal and visual disturbances: case report and review of the literature. ( 7573760 )
1995
36
Optic nerve coloboma (morning glory syndrome): CT findings. ( 8134598 )
1994
37
Bilateral morning glory syndrome associated with sphenoid encephalocele. Case report. ( 1432140 )
1992
38
The Morning Glory syndrome associated with sphenoethmoidal encephalocele. ( 2198507 )
1990
39
Morning glory syndrome associated with marked persistent hyperplastic primary vitreous and lens colobomas. ( 2765452 )
1989
40
Morning glory syndrome and basal encephalocele mimicking a pituitary adenoma. ( 3267440 )
1987
41
Poland syndrome associated with 'morning glory' syndrome (coloboma of the optic disc). ( 3018249 )
1986
42
Treatment of total retinal detachment in morning glory syndrome. ( 6720839 )
1984
43
Basal encephalocele and morning glory syndrome. ( 6849854 )
1983
44
The 'morning glory syndrome' - a mesodermal defect? ( 6657186 )
1983
45
The morning glory syndrome associated with sphenoidal encephalocele. ( 7162782 )
1982
46
Morning Glory Syndrome: a report of two cases. ( 7342922 )
1981

Variations for Morning Glory Syndrome

Expression for Morning Glory Syndrome

Search GEO for disease gene expression data for Morning Glory Syndrome.

Pathways for Morning Glory Syndrome

GO Terms for Morning Glory Syndrome

Biological processes related to Morning Glory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 GJA3 PAX6

Sources for Morning Glory Syndrome

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74 UMLS via Orphanet
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