MCID: MRP002
MIFTS: 24

Morpheaform Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Morpheaform Basal Cell Carcinoma

MalaCards integrated aliases for Morpheaform Basal Cell Carcinoma:

Name: Morpheaform Basal Cell Carcinoma 12 15
Morphea-Type Basal Cell Carcinoma 12
Cicatricial Basal-Cell Carcinoma 12
Basal Cell Carcinoma, Morphea 12
Morpheic Basal Cell Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4292
NCIt 50 C27182
SNOMED-CT 67 403913006
UMLS 70 C0555191

Summaries for Morpheaform Basal Cell Carcinoma

MalaCards based summary : Morpheaform Basal Cell Carcinoma, also known as morphea-type basal cell carcinoma, is related to malignant syringoma and basal cell carcinoma. An important gene associated with Morpheaform Basal Cell Carcinoma is KRT15 (Keratin 15), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Related phenotype is digestive/alimentary.

Related Diseases for Morpheaform Basal Cell Carcinoma

Diseases related to Morpheaform Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 malignant syringoma 30.2 PHLDA1 KRT20 KRT15
2 basal cell carcinoma 29.7 PHLDA1 KRT20 KRT19 KRT17 KRT15
3 skin carcinoma 28.8 PHLDA1 KRT20 KRT19 KRT17 KRT15
4 angiosarcoma 10.3
5 pilar sheath acanthoma 10.1 PHLDA1 KRT15
6 hidradenoma 10.1 PHLDA1 KRT15
7 localized scleroderma 10.1
8 cystic basal cell carcinoma 10.0 KRT20 KRT15
9 fibroepithelial basal cell carcinoma 10.0 PHLDA1 KRT20
10 thymus lipoma 10.0 KRT20 KRT19
11 immune system organ benign neoplasm 10.0 KRT20 KRT19
12 vulvar apocrine adenocarcinoma 10.0 KRT20 KRT19
13 anal canal adenocarcinoma 10.0 KRT20 KRT19
14 adenoid squamous cell carcinoma 10.0 KRT20 KRT19
15 bile duct adenoma 10.0 KRT20 KRT19
16 intrahepatic bile duct adenoma 10.0 KRT20 KRT19
17 lymphoepithelioma-like carcinoma 9.9 KRT20 KRT19
18 benign mesothelioma 9.9 KRT20 KRT19
19 collecting duct carcinoma 9.9 KRT20 KRT19
20 epidermolysis bullosa 9.9 KRT17 KRT15
21 rectum adenocarcinoma 9.9 KRT20 COL1A1
22 cavernous hemangioma 9.9 KRT20 KRT19
23 thymic carcinoma 9.9 KRT20 KRT19
24 gastrointestinal carcinoma 9.9 KRT20 KRT19
25 inverted follicular keratosis 9.9 PHLDA1 KRT17
26 hair follicle neoplasm 9.9 KRT17 KRT15
27 mucinous adenocarcinoma 9.9 KRT20 KRT19
28 skin benign neoplasm 9.9 KRT20 COL1A1
29 pilomatrixoma 9.9 KRT17 KRT15
30 keratoacanthoma 9.9 KRT17 KRT15
31 intrahepatic gall duct cancer 9.9 KRT19 KRT17
32 small cell carcinoma 9.9 KRT20 KRT19
33 hidrocystoma 9.9 PHLDA1 KRT19 KRT15
34 large cell carcinoma 9.9 KRT20 KRT19
35 suppurative thyroiditis 9.9 KRT19 KRT17
36 neuroendocrine carcinoma 9.8 KRT20 KRT19
37 oncocytoma 9.8 KRT20 KRT19
38 peritoneal serous adenocarcinoma 9.8 KRT20 KRT17
39 follicular adenoma 9.8 KRT20 KRT19
40 squamous papillomatosis 9.8 PHLDA1 KRT20 KRT15
41 borst-jadassohn intraepidermal carcinoma 9.8 KRT20 KRT17
42 primary cutaneous amyloidosis 9.8 KRT19 KRT17
43 polycystic liver disease 1 with or without kidney cysts 9.8 KRT20 KRT17
44 ampulla of vater adenocarcinoma 9.8 KRT20 KRT17
45 intrahepatic cholangiocarcinoma 9.8 KRT20 KRT19
46 sweat gland cancer 9.8 KRT20 KRT19 KRT15
47 pre-malignant neoplasm 9.8 KRT19 KRT17
48 ampulla of vater cancer 9.7 KRT20 KRT17
49 papillary carcinoma 9.7 KRT20 KRT19
50 actinic keratosis 9.7 KRT20 KRT17

Graphical network of the top 20 diseases related to Morpheaform Basal Cell Carcinoma:



Diseases related to Morpheaform Basal Cell Carcinoma

Symptoms & Phenotypes for Morpheaform Basal Cell Carcinoma

MGI Mouse Phenotypes related to Morpheaform Basal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 COL1A1 KRT15 KRT17 KRT19

Drugs & Therapeutics for Morpheaform Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Morpheaform Basal Cell Carcinoma

Genetic Tests for Morpheaform Basal Cell Carcinoma

Anatomical Context for Morpheaform Basal Cell Carcinoma

Publications for Morpheaform Basal Cell Carcinoma

Articles related to Morpheaform Basal Cell Carcinoma:

(show all 33)
# Title Authors PMID Year
1
Orbito-scleral-sinus invasion of basal cell carcinoma in an immunocompromised patient on vismodegib. 61
32283962 2021
2
A Non-Surgical and Cost-Effective Treatment Approach Employing Topical Imiquimod, 5-Fluorouracil, and Tretinoin for Primary Non-Melanoma Skin Cancers. 61
33683072 2021
3
Dermoscopic characteristics of microcystic adnexal carcinoma, desmoplastic trichoepithelioma, and morpheaform basal cell carcinoma. 61
32686120 2021
4
Angiosarcoma imitating a morpheaform basal cell carcinoma. 61
32186542 2020
5
Desmoplastic Trichoepithelioma: An Uncommon but Diagnostically Problematic Benign Adnexal Tumor. 61
31969246 2019
6
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours. 61
28681209 2017
7
A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin. 61
29279559 2017
8
Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin. 61
27043336 2016
9
Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma. 61
26016446 2015
10
Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature. 61
26622873 2015
11
Histological and immunohistochemical study of the eyelid basal cell carcinomas. 61
26429176 2015
12
Fluorouracil and other predictors of morpheaform basal cell carcinoma among high-risk patients: the Veterans Affairs Topical Tretinoin Chemoprevention Trial. 61
24258386 2014
13
The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. 61
23398472 2013
14
Diagnostic utility of cytokeratin 17 immunostaining in morpheaform basal cell carcinoma and for facilitating the detection of tumor cells at the surgical margins. 61
22691048 2012
15
Commentary: diagnostic utility of cytokeratin 17 immunostaining in morpheaform basal cell carcinoma and for facilitating the detection of tumor cells at the surgical margins. 61
22861061 2012
16
Photodynamic therapy as adjunctive therapy for morpheaform basal cell carcinoma. 61
21879201 2011
17
Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery. 61
20540416 2010
18
Angiosarcoma clinically resembling morpheaform basal cell carcinoma. 61
18637812 2008
19
Three different consecutive manifestations of morphoeic BCC in the same patient: presenting first as ectropion, then entropion, and finally medial canthal dystopia with epicanthus inversus. 61
18569825 2008
20
The expression of CD23 in cutaneous non-lymphoid neoplasms. 61
17696916 2007
21
Morpheaform basal cell carcinoma in African Americans. 61
15606838 2004
22
Predictors of extensive subclinical spread in nonmelanoma skin cancer treated with Mohs micrographic surgery. 61
12164742 2002
23
Can smoking and/or occupational UV exposure have any role in the development of the morpheaform basal cell carcinoma? A critical role for peritumoral mast cells. 61
12100702 2002
24
Serial excision of a large facial skin cancer. 61
10759829 2000
25
Clinical factors influencing periocular surgical defects after Mohs micrographic surgery. 61
10189634 1999
26
Analysis of morpheaform basal cell carcinoma. 61
3220994 1988
27
Morpheaform basal cell carcinoma in a young black woman. 61
3343426 1988
28
Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes. 61
3279155 1988
29
Dermatofibrosarcoma non-protuberans: description and report of five cases of a morpheaform variant of dermatofibrosarcoma. 61
2578589 1985
30
Auricular malignant neoplasms. Identification of high-risk lesions and selection of method of reconstruction. 61
7073593 1982
31
Auricular malignant neoplasms. When is chemotherapy (Mohs' technique) necessary? 61
7295168 1981
32
Desmoplastic malignant melanoma. 61
1137419 1975
33
Morpheaform basal cell carcinoma. 61
5676900 1968

Variations for Morpheaform Basal Cell Carcinoma

Expression for Morpheaform Basal Cell Carcinoma

Search GEO for disease gene expression data for Morpheaform Basal Cell Carcinoma.

Pathways for Morpheaform Basal Cell Carcinoma

Pathways related to Morpheaform Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 KRT20 KRT19 KRT17 KRT15
2
Show member pathways
11.95 KRT20 KRT19 KRT17 KRT15 COL1A1
3 11.92 KRT20 KRT19 KRT17
4
Show member pathways
11.91 KRT20 KRT19 KRT17 KRT15
5
Show member pathways
11.4 KRT19 KRT17
6 10.91 KRT20 KRT19 KRT17 KRT15

GO Terms for Morpheaform Basal Cell Carcinoma

Cellular components related to Morpheaform Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.96 KRT19 KRT17
2 intermediate filament GO:0005882 8.92 KRT20 KRT19 KRT17 KRT15

Biological processes related to Morpheaform Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT20 KRT19 KRT17 KRT15
2 intermediate filament organization GO:0045109 9.16 KRT20 KRT17
3 cornification GO:0070268 8.92 KRT20 KRT19 KRT17 KRT15

Molecular functions related to Morpheaform Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT20 KRT19 KRT15
2 structural molecule activity GO:0005198 8.92 KRT20 KRT19 KRT17 KRT15

Sources for Morpheaform Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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