MCID: MRP001
MIFTS: 43

Morphine Dependence

Categories: Mental diseases

Aliases & Classifications for Morphine Dependence

MalaCards integrated aliases for Morphine Dependence:

Name: Morphine Dependence 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2560
MeSH 44 D009021
UMLS 73 C0026552

Summaries for Morphine Dependence

Disease Ontology : 12 An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.

MalaCards based summary : Morphine Dependence is related to heroin dependence and opioid abuse. An important gene associated with Morphine Dependence is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cytokine Signaling in Immune system. The drugs Buprenorphine and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Morphine Dependence

Diseases related to Morphine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 heroin dependence 30.1 OPRD1 OPRM1
2 opioid abuse 10.4 CCK OPRM1
3 chronic pain 10.3 OPRM1 PTGS2
4 neonatal abstinence syndrome 10.3 OPRD1 OPRK1 OPRM1
5 bile reflux 10.3 CCK PTGS2
6 opiate dependence 10.3 OPRD1 OPRK1 OPRM1
7 cocaine dependence 10.3 OPRD1 OPRK1 OPRM1
8 drug dependence 10.3 OPRD1 OPRK1 OPRM1
9 substance dependence 10.2 OPRD1 OPRK1 OPRM1
10 neuronitis 10.1
11 aspirin resistance 10.1 PTGS1 PTGS2
12 active peptic ulcer disease 10.1 PTGS1 PTGS2
13 opioid addiction 10.0 CCK OPRD1 OPRK1 OPRM1
14 specific developmental disorder 9.8 CCK OPRM1 TRPV1
15 anxiety 9.8
16 cerebritis 9.8
17 hydrops, lactic acidosis, and sideroblastic anemia 9.8 ALOX5 PTGS1 PTGS2
18 withdrawal disorder 9.7 FOS OPRM1
19 esophageal disease 9.7 PTGS2 TRPV1
20 functional gastric disease 9.7 CCK PTGS2 TRPV1
21 neuroblastoma 9.7
22 aging 9.7
23 depression 9.7
24 gastrointestinal system disease 9.6 CCK PTGS2 TRPV1
25 antenatal bartter syndrome 9.5 PTGS1 PTGS2
26 alcohol dependence 9.4 CCK GRIN1 OPRD1 OPRK1 OPRM1
27 dyspepsia 9.1 CCK PTGS1 PTGS2 TRPV1
28 stomach disease 9.1 CCK PTGS1 PTGS2 TRPV1
29 gastroesophageal reflux 9.1 CCK PTGS1 PTGS2 TRPV1
30 disease of mental health 8.9 CCK FOS OPRM1 TRPV1
31 inflammatory bowel disease 8.5 ALOX5 PTGS1 PTGS2 TRPV1
32 pain agnosia 8.1 CCK FOS OPRK1 OPRM1 PTGS2 TRPV1
33 agnosia 8.1 CCK FOS OPRK1 OPRM1 PTGS2 TRPV1

Graphical network of the top 20 diseases related to Morphine Dependence:



Diseases related to Morphine Dependence

Symptoms & Phenotypes for Morphine Dependence

MGI Mouse Phenotypes related to Morphine Dependence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 CCK FOS GRIN1 OPRD1 OPRK1 OPRM1
2 homeostasis/metabolism MP:0005376 10.1 OPRK1 OPRM1 PTGS1 PTGS2 SLC1A2 TRPV1
3 cellular MP:0005384 10.02 ADCY10 ALOX5 FOS GRIN1 OPRM1 PTGS1
4 nervous system MP:0003631 9.85 CCK FOS GRIN1 OPRD1 OPRK1 OPRM1
5 integument MP:0010771 9.8 FOS OPRD1 OPRK1 OPRM1 PTGS1 PTGS2
6 no phenotypic analysis MP:0003012 9.5 OPRD1 OPRM1 PTGS2 TRPV1 ADCY10 CCK
7 reproductive system MP:0005389 9.17 ADCY10 FOS GRIN1 OPRK1 OPRM1 PTGS1

Drugs & Therapeutics for Morphine Dependence

Drugs for Morphine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
2
Clonidine Approved Phase 3 4205-90-7 2803
3
Morphine Approved, Investigational Phase 3 57-27-2 5288826
4
Naloxone Approved, Vet_approved Phase 3 465-65-6 5284596
5 Adrenergic Agents Phase 3
6 Adrenergic Agonists Phase 3
7 Adrenergic alpha-2 Receptor Agonists Phase 3
8 Adrenergic alpha-Agonists Phase 3
9 Analgesics Phase 3
10 Analgesics, Opioid Phase 3
11 Antihypertensive Agents Phase 3
12 Autonomic Agents Phase 3
13 Buprenorphine, Naloxone Drug Combination Phase 3
14 Central Nervous System Depressants Phase 3
15 Narcotic Antagonists Phase 3
16 Narcotics Phase 3
17 Neurotransmitter Agents Phase 3
18 Opiate Alkaloids Phase 3
19 Peripheral Nervous System Agents Phase 3
20 Sympatholytics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1 Completed NCT00032955 Phase 3 Buprenorphine/naloxone
2 Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1 Completed NCT00032968 Phase 3 Buprenorphine/naloxone

Search NIH Clinical Center for Morphine Dependence

Cochrane evidence based reviews: morphine dependence

Genetic Tests for Morphine Dependence

Anatomical Context for Morphine Dependence

MalaCards organs/tissues related to Morphine Dependence:

41
Brain, Spinal Cord, Cortex, Hypothalamus, Kidney, Caudate Nucleus, Prefrontal Cortex

Publications for Morphine Dependence

Articles related to Morphine Dependence:

(show top 50) (show all 236)
# Title Authors Year
1
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. ( 29483538 )
2018
2
Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways. ( 29223784 )
2018
3
Inhibiting social support from massage-like stroking increases morphine dependence. ( 29049082 )
2017
4
Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice. ( 28130112 )
2017
5
Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons. ( 28888954 )
2017
6
Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. ( 28341892 )
2017
7
Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. ( 29116553 )
2017
8
Effect of the methanolic extracts of different parts of<i>Ferula assa-foetida</i>on naloxone-induced withdrawal behavior in morphine-dependent mice. ( 29062804 )
2017
9
Prolonged ventricular infusion of ginsenosides attenuated morphine dependence. ( 27976116 )
2016
10
Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats. ( 28144409 )
2016
11
Opioid agonist doses for oxycodone and morphine dependence: Findings from a retrospective case series. ( 27273511 )
2016
12
Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. ( 27618384 )
2016
13
Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. ( 27289274 )
2016
14
Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K. ( 27746699 )
2016
15
Integrated workflow for quantitative phosphoproteomic analysis of the selected brain structures in development of morphine dependence. ( 25443728 )
2014
16
NF-I_B signaling and vesicle transport are correlated with the reactivation of the memory trace of morphine dependence. ( 25012590 )
2014
17
Social housing conditions influence morphine dependence and the extinction of morphine place preference in adolescent mice. ( 25048393 )
2014
18
Morphine dependence in single enteric neurons from the mouse colon requires deletion of I^-arrestin2. ( 25194025 )
2014
19
Differential Changes in Expression of Stress- and Metabolic-Related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal. ( 23805290 )
2013
20
Pioglitazone potentiates development of morphine-dependence in mice: possible role of NO/cGMP pathway. ( 23399681 )
2013
21
Comparative proteomic analysis of the nucleus accumbens during extinction and reinstatement of morphine dependence. ( 24564042 )
2013
22
Involvement of hippocampal phosphatidylethanolamine-binding protein in morphine dependence and withdrawal. ( 21967037 )
2013
23
Morphine dependence and withdrawal induced changes in cholinergic signaling. ( 23651795 )
2013
24
Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. ( 23684726 )
2013
25
Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. ( 22682150 )
2012
26
Dopamine affects the change of pain-related electrical activity induced by morphine dependence. ( 22240902 )
2012
27
Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. ( 22040728 )
2012
28
Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence. ( 21967557 )
2012
29
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. ( 24900506 )
2012
30
Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention. ( 22123079 )
2012
31
Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats. ( 23269899 )
2012
32
A^H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention. ( 22391120 )
2012
33
The effect of morphine dependence on impulsive choice in rats. ( 22588252 )
2012
34
Morphinome--a meta-analysis applied to proteomics studies in morphine dependence. ( 21182190 )
2011
35
Distribution of TRPC6 in the cerebrospinal fluid-contacting nucleus of rat brain parenchyma and its expression in morphine dependence and withdrawal. ( 21858483 )
2011
36
Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management. ( 21886595 )
2011
37
JWA regulates chronic morphine dependence via the delta opioid receptor. ( 21600884 )
2011
38
Participation of L-type voltage-gated calcium channels in facilitation of long-term potentiation during the formation of morphine dependence in rats. ( 21240373 )
2010
39
Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. ( 20438612 )
2010
40
Study of the intraplantar injection of lidocaine and morphine on pain perception and the influence of morphine dependence and withdrawal on lidocaine-induced analgesia in rats. ( 21283259 )
2010
41
Modulation of opiate-related signaling molecules in morphine-dependent conditioned behavior: conditioned place preference to morphine induces CREB phosphorylation. ( 19956087 )
2010
42
A role for the parafascicular thalamic nucleus in the development of morphine dependence and withdrawal. ( 19332040 )
2009
43
Relative potency of the opioid antagonists naloxone and 6-alpha-naloxol to precipitate withdrawal from acute morphine dependence varies with time post-antagonist. ( 19061911 )
2009
44
Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. ( 19183220 )
2009
45
Melatonin enhances the expression of I^-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice. ( 19536438 )
2009
46
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( 19356733 )
2009
47
Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence. ( 19640720 )
2009
48
Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus. ( 18474221 )
2008
49
Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats. ( 18618337 )
2008
50
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. ( 18472145 )
2008

Variations for Morphine Dependence

Expression for Morphine Dependence

Search GEO for disease gene expression data for Morphine Dependence.

Pathways for Morphine Dependence

Pathways related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CCK GRIN1 OPRD1 OPRK1 OPRM1 TRPV1
2
Show member pathways
12.96 ALOX5 FOS GRIN1 OPRD1 OPRM1 PTGS2
3
Show member pathways
12.82 GRIN1 OPRM1 PTGS1 PTGS2 TRPV1
4
Show member pathways
12.67 ADCY10 FOS GRIN1 OPRM1 SLC1A2
5 12.19 GRIN1 OPRM1 PTGS1 PTGS2 SLC1A2
6
Show member pathways
12.11 ALOX5 PTGS1 PTGS2
7
Show member pathways
12.08 ADCY10 FOS GRIN1
8
Show member pathways
12.02 ALOX5 FOS PTGS2
9
Show member pathways
11.94 ALOX5 PTGS1 PTGS2
10 11.73 FOS GRIN1 PTGS2
11
Show member pathways
11.7 ALOX5 PTGS1 PTGS2
12 11.66 ALOX5 PTGS1 PTGS2
13
Show member pathways
11.08 FOS TRPV1
14 11.08 ALOX5 FOS OPRD1 OPRM1 PTGS2
15 11.05 PTGS1 PTGS2
16 11 PTGS1 PTGS2
17 10.9 PTGS1 PTGS2
18 10.8 PTGS1 PTGS2
19
Show member pathways
10.76 ALOX5 PTGS1 PTGS2
20 10.67 PTGS1 PTGS2
21 10.51 ALOX5 PTGS1 PTGS2
22
Show member pathways
10.1 ALOX5 PTGS2

GO Terms for Morphine Dependence

Cellular components related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.88 GRIN1 OPRD1 OPRK1 OPRM1 SLC1A2 TRPV1
2 postsynaptic membrane GO:0045211 9.65 GRIN1 OPRD1 TRPV1
3 neuronal cell body GO:0043025 9.62 ADCY10 CCK OPRK1 TRPV1
4 dendrite membrane GO:0032590 9.46 OPRD1 OPRM1
5 axon GO:0030424 9.46 ADCY10 CCK OPRM1 SLC1A2
6 intrinsic component of plasma membrane GO:0031226 9.43 OPRD1 TRPV1
7 perikaryon GO:0043204 9.43 CCK OPRK1 OPRM1
8 dendrite GO:0030425 9.43 ADCY10 CCK GRIN1 OPRK1 OPRM1 TRPV1
9 neuron projection GO:0043005 9.17 FOS GRIN1 OPRD1 OPRK1 OPRM1 PTGS2
10 membrane GO:0016020 10.11 ADCY10 ALOX5 FOS GRIN1 OPRD1 OPRK1

Biological processes related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 ALOX5 FOS PTGS1 PTGS2 TRPV1
2 chemical synaptic transmission GO:0007268 9.86 OPRD1 OPRK1 OPRM1 SLC1A2
3 response to lipopolysaccharide GO:0032496 9.82 FOS OPRM1 PTGS2
4 response to ethanol GO:0045471 9.77 GRIN1 OPRK1 OPRM1
5 positive regulation of apoptotic process GO:0043065 9.77 ADCY10 CCK GRIN1 PTGS2 TRPV1
6 neuropeptide signaling pathway GO:0007218 9.75 OPRD1 OPRK1 OPRM1
7 excitatory postsynaptic potential GO:0060079 9.72 GRIN1 OPRM1 TRPV1
8 cytokine-mediated signaling pathway GO:0019221 9.72 ALOX5 FOS OPRD1 OPRM1 PTGS2
9 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.71 OPRD1 OPRK1 OPRM1
10 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.7 OPRD1 OPRK1 OPRM1
11 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.69 OPRD1 OPRK1 OPRM1
12 response to cocaine GO:0042220 9.65 OPRK1 OPRM1
13 response to organonitrogen compound GO:0010243 9.65 PTGS2 TRPV1
14 response to light stimulus GO:0009416 9.64 FOS SLC1A2
15 glutamate secretion GO:0014047 9.63 SLC1A2 TRPV1
16 prostaglandin metabolic process GO:0006693 9.63 PTGS1 PTGS2
17 response to radiation GO:0009314 9.63 OPRK1 OPRM1 PTGS2
18 cellular response to extracellular stimulus GO:0031668 9.62 FOS SLC1A2
19 lipoxygenase pathway GO:0019372 9.62 ALOX5 PTGS2
20 prostaglandin biosynthetic process GO:0001516 9.61 PTGS1 PTGS2
21 estrous cycle GO:0044849 9.61 OPRK1 OPRM1
22 cellular response to ATP GO:0071318 9.59 PTGS2 TRPV1
23 sensory perception GO:0007600 9.58 OPRK1 OPRM1
24 response to morphine GO:0043278 9.58 GRIN1 OPRK1 OPRM1
25 cyclooxygenase pathway GO:0019371 9.57 PTGS1 PTGS2
26 conditioned taste aversion GO:0001661 9.49 FOS GRIN1
27 regulation of sensory perception of pain GO:0051930 9.46 CCK OPRD1 OPRK1 OPRM1
28 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.43 OPRK1 OPRM1
29 opioid receptor signaling pathway GO:0038003 9.43 OPRD1 OPRK1 OPRM1
30 eating behavior GO:0042755 9.26 CCK OPRD1 OPRK1 OPRM1
31 sensory perception of pain GO:0019233 9.1 GRIN1 OPRD1 OPRK1 OPRM1 PTGS2 TRPV1

Molecular functions related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.5 ALOX5 PTGS1 PTGS2
2 peptide binding GO:0042277 9.43 OPRD1 OPRK1 OPRM1
3 peroxidase activity GO:0004601 9.4 PTGS1 PTGS2
4 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 9.37 ALOX5 PTGS2
5 prostaglandin-endoperoxide synthase activity GO:0004666 9.16 PTGS1 PTGS2
6 neuropeptide binding GO:0042923 9.13 OPRD1 OPRK1 OPRM1
7 opioid receptor activity GO:0004985 8.8 OPRD1 OPRK1 OPRM1

Sources for Morphine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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