MCID: MRP001
MIFTS: 41

Morphine Dependence

Categories: Mental diseases

Aliases & Classifications for Morphine Dependence

MalaCards integrated aliases for Morphine Dependence:

Name: Morphine Dependence 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2560
MeSH 43 D009021
UMLS 71 C0026552

Summaries for Morphine Dependence

Disease Ontology : 12 An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.

MalaCards based summary : Morphine Dependence is related to opioid addiction and chronic pain. An important gene associated with Morphine Dependence is OPRK1 (Opioid Receptor Kappa 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Clonidine and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Morphine Dependence

Diseases related to Morphine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 opioid addiction 30.8 OPRM1 OPRK1 OPRD1 CCK
2 chronic pain 30.4 PTGS2 OPRM1
3 heroin dependence 29.8 PDYN OPRM1 OPRD1
4 opioid abuse 29.6 PDYN OPRM1 OPRL1 OPRK1 OPRD1 CCK
5 pertussis 29.6 OPRM1 FOS ADCY10
6 substance abuse 29.5 PDYN OPRM1 OPRL1 OPRK1 OPRD1
7 withdrawal disorder 29.4 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
8 drug dependence 29.2 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
9 sleep disorder 29.0 HCRTR1 HCRT FOS
10 opiate dependence 28.7 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
11 constipation 28.5 PTGS2 PTGS1 PDYN OPRM1 OPRL1 OPRK1
12 pain agnosia 27.7 PTGS2 PENK PDYN OXT OPRM1 OPRL1
13 anxiety 27.5 PDYN OXT OPRM1 OPRL1 OPRK1 OPRD1
14 diarrhea 10.4
15 ptosis 10.4
16 tremor 10.4
17 aspirin resistance 10.3 PTGS2 PTGS1
18 fibromyalgia 10.2 OPRM1 OPRK1 OPRD1
19 kidney papillary necrosis 10.2 PTGS2 PTGS1
20 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2 PTGS2 PTGS1
21 autonomic nervous system disease 10.2 OPRM1 OPRL1 OPRD1
22 paine syndrome 10.2 OPRM1 OPRL1 OPRD1
23 somatoform disorder 10.2 OPRM1 OPRL1 OPRD1
24 active peptic ulcer disease 10.1 PTGS2 PTGS1
25 hydrops, lactic acidosis, and sideroblastic anemia 10.1 PTGS2 PTGS1 ALOX5
26 irritable bowel syndrome 10.1 OPRM1 FOS CCK
27 cerebral hypoxia 10.1 FOS CREB1
28 paralytic ileus 10.1 OPRM1 OPRL1 OPRK1 OPRD1
29 neonatal abstinence syndrome 10.1 OPRM1 OPRL1 OPRK1 OPRD1
30 trigeminal nerve disease 10.1 OPRM1 OPRL1 OPRK1 OPRD1
31 trigeminal neuralgia 10.1 OPRM1 OPRL1 OPRK1 OPRD1
32 proteasome-associated autoinflammatory syndrome 1 10.1 PTGS2 PTGS1 ALOX5
33 chronic cystitis 10.0 PTGS2 PTGS1
34 cocaine dependence 10.0 PDYN OPRM1 OPRK1 OPRD1
35 urticaria 10.0 PTGS2 PTGS1 ALOX5
36 substance dependence 10.0 PDYN OPRM1 OPRK1 OPRD1
37 bile reflux 10.0 PTGS2 CCK
38 angioedema 10.0 PTGS2 PTGS1 ALOX5
39 rohhad 9.9 HCRTR1 HCRT
40 psychotic disorder 9.9 PDYN OXT OPRM1 CCK
41 gastroesophageal reflux 9.9 PTGS2 PTGS1 CCK
42 cholera 9.9
43 glioblastoma multiforme 9.9
44 neuroblastoma 9.9
45 48,xyyy 9.9
46 retrograde amnesia 9.9 PDYN FOS CREB1
47 status epilepticus 9.8 SLC1A2 GRIN1 FOS
48 toxic encephalopathy 9.7 SLC1A2 PTGS2 CREB1
49 aminopterin syndrome sine aminopterin 9.7
50 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.7

Graphical network of the top 20 diseases related to Morphine Dependence:



Diseases related to Morphine Dependence

Symptoms & Phenotypes for Morphine Dependence

MGI Mouse Phenotypes related to Morphine Dependence:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 CREB1 FOS GRIN1 HCRT HCRTR1 OPRD1
2 homeostasis/metabolism MP:0005376 10.3 ADCY10 ALOX5 CCK CREB1 FOS GRIN1
3 nervous system MP:0003631 10.13 CCK CREB1 FOS GRIN1 HCRT HCRTR1
4 endocrine/exocrine gland MP:0005379 10.06 CCK CREB1 FOS OPRK1 OPRM1 OXT
5 integument MP:0010771 10.02 FOS OPRD1 OPRK1 OPRL1 OPRM1 OXT
6 no phenotypic analysis MP:0003012 9.76 ADCY10 CCK GRIN1 OPRD1 OPRM1 PDYN
7 normal MP:0002873 9.56 CREB1 FOS GRIN1 OPRL1 OPRM1 PENK
8 reproductive system MP:0005389 9.32 ADCY10 CREB1 FOS GRIN1 OPRK1 OPRM1

Drugs & Therapeutics for Morphine Dependence

Drugs for Morphine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 3 4205-90-7 2803
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
3
Naloxone Approved, Vet_approved Phase 3 465-65-6 5284596
4
Morphine Approved, Investigational Phase 3 57-27-2 5288826
5 Narcotics Phase 3
6 Analgesics Phase 3
7 Antihypertensive Agents Phase 3
8 Adrenergic alpha-2 Receptor Agonists Phase 3
9 Neurotransmitter Agents Phase 3
10 Analgesics, Opioid Phase 3
11 Buprenorphine, Naloxone Drug Combination Phase 3
12 Opiate Alkaloids Phase 3
13 Central Nervous System Depressants Phase 3
14 Adrenergic Agonists Phase 3
15 Autonomic Agents Phase 3
16 Adrenergic Agents Phase 3
17 Sympatholytics Phase 3
18 Narcotic Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Buprenorphine/Naloxone Versus Clonidine For Out-patient Opiate Detoxification Completed NCT00032968 Phase 3 Buprenorphine/naloxone
2 Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification Completed NCT00032955 Phase 3 Buprenorphine/naloxone

Search NIH Clinical Center for Morphine Dependence

Cochrane evidence based reviews: morphine dependence

Genetic Tests for Morphine Dependence

Anatomical Context for Morphine Dependence

MalaCards organs/tissues related to Morphine Dependence:

40
Brain, Spinal Cord, Cortex, Hypothalamus, Heart, Amygdala, Pituitary

Publications for Morphine Dependence

Articles related to Morphine Dependence:

(show top 50) (show all 711)
# Title Authors PMID Year
1
[Opioid receptors altered binding nature in guinea-pig brain following the development of morphine dependence]. 54 61
8544279 1995
2
Venlafaxine inhibits naloxone-precipitated morphine withdrawal symptoms: Role of inflammatory cytokines and nitric oxide. 61
31630319 2020
3
Age- and sex-related changes in the severity of physical and psychological dependence in morphine-dependent rats. 61
31639387 2019
4
Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats. 61
31424230 2019
5
The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence. 61
31998461 2019
6
Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice. 61
31544297 2019
7
Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats. 61
31051222 2019
8
Dezocine Alleviates Morphine-Induced Dependence in Rats. 61
31094808 2019
9
The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence. 61
30902386 2019
10
Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor. 61
30584942 2019
11
Fluoxetine increases analgesic effects of morphine, prevents development of morphine tolerance and dependence through the modulation of L-type calcium channels expression in mice. 61
30550947 2019
12
Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats. 61
30632088 2019
13
The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice. 61
30689982 2019
14
Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence. 61
30634592 2019
15
Selection and Validation of Reference Genes for RT-PCR Expression Analysis of Candidate Genes Involved in Morphine-Induced Conditioned Place Preference Mice. 61
30386959 2018
16
The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. 61
30258112 2018
17
Chromium picolinate reduces morphine-dependence in rats, while increasing brain serotonin levels. 61
30269760 2018
18
Modulation of miR-139-5p on chronic morphine-induced, naloxone-precipitated cAMP overshoot in vitro. 61
29916183 2018
19
Naloxone precipitated morphine withdrawal and clock genes expression in striatum: A comparative study in three different protocols for the development of morphine dependence. 61
30030165 2018
20
Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes. 61
30227624 2018
21
Magnesium in addiction - a general view. 61
30714574 2018
22
The effect of metformin on morphine analgesic tolerance and dependence in rats. 61
30065764 2018
23
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. 61
29859324 2018
24
Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice. 61
29939746 2018
25
Hippocampal glial cells modulate morphine-induced behavioral responses. 61
29626506 2018
26
Effects of Clavulanic Acid on the Acquisition and Reinstatement Following Morphine-induced Conditioned Place Preference in Mice. 61
30519387 2018
27
Effect of Yulangsan Polysaccharide on the Reinstatement of Morphine-Induced Conditioned Place Preference in Sprague-Dawley Rats. 61
29455417 2018
28
Hyperbaric Oxygen Attenuates Withdrawal Symptoms by Regulating Monoaminergic Neurotransmitters and NO Signaling Pathway at Nucleus Accumbens in Morphine-Dependent Rats. 61
29313212 2018
29
Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways. 61
29223784 2018
30
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. 61
29483538 2018
31
Over-expression of CCK1 Receptor Reverse Morphine Dependence. 61
30147637 2018
32
Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats. 61
29031903 2018
33
The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. 61
28782589 2018
34
Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats. 61
28933310 2018
35
Proteomic Data in Morphine Addiction Versus Real Protein Activity: Metabolic Enzymes. 61
28430368 2017
36
Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). 61
28986608 2017
37
Inhibiting social support from massage-like stroking increases morphine dependence. 61
29049082 2017
38
Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. 61
29116553 2017
39
Experimental Research Showing the Reduction of Naloxone-Place Aversion by Oral Zinc Administration in Rats. 61
28337700 2017
40
Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons. 61
28888954 2017
41
Maternal swimming exercise during pregnancy attenuates anxiety/depressive-like behaviors and voluntary morphine consumption in the pubertal male and female rat offspring born from morphine dependent mothers. 61
28867589 2017
42
Simvastatin prevents morphine-induced tolerance and dependence in mice. 61
28654797 2017
43
Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 61
28583577 2017
44
Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. 61
27618384 2017
45
Opioid agonist doses for oxycodone and morphine dependence: Findings from a retrospective case series. 61
27273511 2017
46
Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. 61
28341892 2017
47
Evaluation of the CART peptide expression in morphine sensitization in male rats. 61
28238767 2017
48
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. 61
28319053 2017
49
Intracoerulear microinjection of orexin-A induces morphine withdrawal-like signs in rats. 61
28093335 2017
50
Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice. 61
28130112 2017

Variations for Morphine Dependence

Expression for Morphine Dependence

Search GEO for disease gene expression data for Morphine Dependence.

Pathways for Morphine Dependence

Pathways related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 PENK PDYN OXT OPRM1 OPRL1 OPRK1
2
Show member pathways
12.98 PENK PDYN OXT OPRM1 OPRL1 OPRK1
3
Show member pathways
12.93 PTGS2 PTGS1 PDYN OPRM1 GRIN1 CREB1
4
Show member pathways
12.59 SLC1A2 GRIN1 FOS CREB1 ADCY10
5
Show member pathways
12.47 PTGS2 PDYN GRIN1 FOS CREB1
6
Show member pathways
12.38 PDYN OPRM1 CREB1 CCT6A
7
Show member pathways
12.24 PTGS2 PTGS1 FOS CREB1
8 11.99 OXT GRIN1 FOS CREB1 ADCY10
9
Show member pathways
11.85 PTGS2 PTGS1 ALOX5
10 11.83 PTGS2 PTGS1 ALOX5
11 11.81 PTGS2 PDYN GRIN1 FOS
12 11.8 PTGS2 FOS CREB1
13
Show member pathways
11.78 PDYN GRIN1 FOS CREB1
14 11.7 SLC1A2 PTGS2 PTGS1 OPRM1 HCRT GRIN1
15
Show member pathways
11.69 PDYN GRIN1 CREB1
16 11.61 PTGS2 OPRM1 OPRD1 FOS ALOX5
17 11.48 OPRK1 GRIN1 CREB1
18
Show member pathways
10.98 PTGS2 PTGS1 ALOX5
19 10.89 PTGS2 PTGS1
20 10.88 PTGS2 PTGS1 ALOX5
21 10.85 FOS CREB1
22 10.74 PTGS2 PTGS1
23
Show member pathways
10.27 PTGS2 ALOX5

GO Terms for Morphine Dependence

Cellular components related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 SLC1A2 OPRM1 OPRL1 OPRK1 OPRD1 HCRTR1
2 integral component of presynaptic membrane GO:0099056 9.54 SLC1A2 OPRM1 OPRD1
3 axon terminus GO:0043679 9.5 PENK PDYN OPRD1
4 terminal bouton GO:0043195 9.43 OXT GRIN1 CCK
5 dendrite GO:0030425 9.43 PENK PDYN OPRM1 GRIN1 CCK ADCY10
6 spine apparatus GO:0097444 9.16 OPRM1 OPRD1
7 axon GO:0030424 9.1 SLC1A2 PENK OPRM1 CREB1 CCK ADCY10

Biological processes related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.23 PENK OXT OPRM1 OPRL1 OPRK1 OPRD1
2 G protein-coupled receptor signaling pathway GO:0007186 10.07 PENK PDYN OXT OPRM1 OPRL1 OPRK1
3 positive regulation of apoptotic process GO:0043065 10 PTGS2 GRIN1 CREB1 CCK ADCY10
4 response to drug GO:0042493 9.97 SLC1A2 PTGS2 FOS CREB1
5 cytokine-mediated signaling pathway GO:0019221 9.96 PTGS2 OPRM1 OPRD1 FOS ALOX5
6 aging GO:0007568 9.91 PTGS2 PENK FOS CREB1
7 response to lipopolysaccharide GO:0032496 9.91 PTGS2 PENK OPRM1 FOS
8 chemical synaptic transmission GO:0007268 9.91 SLC1A2 PENK PDYN OPRK1 HCRTR1 HCRT
9 response to ethanol GO:0045471 9.85 PENK OPRM1 GRIN1
10 response to estradiol GO:0032355 9.84 PTGS2 PENK OXT OPRL1
11 locomotory behavior GO:0007626 9.83 PENK OPRM1 OPRK1
12 excitatory postsynaptic potential GO:0060079 9.81 OPRM1 HCRT GRIN1
13 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.81 OPRM1 OPRK1 OPRD1 HCRT
14 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.8 OPRM1 OPRL1 OPRK1 OPRD1
15 memory GO:0007613 9.8 PTGS2 OXT GRIN1 CREB1 CCK
16 visual learning GO:0008542 9.77 GRIN1 CREB1 CCK
17 response to radiation GO:0009314 9.74 PTGS2 PENK OPRM1
18 response to morphine GO:0043278 9.72 PENK OPRM1 GRIN1
19 cellular response to extracellular stimulus GO:0031668 9.68 SLC1A2 FOS
20 estrous cycle GO:0044849 9.67 OPRM1 OPRL1
21 lipoxygenase pathway GO:0019372 9.66 PTGS2 ALOX5
22 startle response GO:0001964 9.66 PENK GRIN1
23 prostaglandin biosynthetic process GO:0001516 9.65 PTGS2 PTGS1
24 cyclooxygenase pathway GO:0019371 9.65 PTGS2 PTGS1
25 sleep GO:0030431 9.65 OXT HCRT FOS
26 regulation of sensory perception of pain GO:0051930 9.65 OXT OPRM1 OPRL1 OPRD1 CCK
27 behavior GO:0007610 9.64 OPRL1 OPRK1
28 positive regulation of behavioral fear response GO:2000987 9.63 PENK CCK
29 positive regulation of sensory perception of pain GO:1904058 9.63 OPRL1 CCK
30 sensory perception GO:0007600 9.63 OPRM1 OPRL1 OPRK1
31 sensory perception of pain GO:0019233 9.63 PTGS2 PENK OPRM1 OPRL1 OPRK1 GRIN1
32 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.62 OPRM1 OPRL1
33 male mating behavior GO:0060179 9.62 OXT GRIN1
34 opioid receptor signaling pathway GO:0038003 9.62 OPRM1 OPRL1 OPRK1 OPRD1
35 conditioned taste aversion GO:0001661 9.58 GRIN1 FOS
36 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.52 OPRM1 OPRK1
37 eating behavior GO:0042755 9.43 OXT OPRM1 OPRL1 OPRD1 HCRT CCK
38 neuropeptide signaling pathway GO:0007218 9.23 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1

Molecular functions related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.61 PTGS2 PTGS1 ALOX5
2 peptide binding GO:0042277 9.56 OPRM1 OPRL1 OPRK1 OPRD1
3 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 9.46 PTGS2 ALOX5
4 neuropeptide hormone activity GO:0005184 9.46 PENK OXT HCRT CCK
5 opioid receptor binding GO:0031628 9.4 PENK PDYN
6 opioid peptide activity GO:0001515 9.37 PENK PDYN
7 prostaglandin-endoperoxide synthase activity GO:0004666 9.32 PTGS2 PTGS1
8 neuropeptide binding GO:0042923 9.26 OPRM1 OPRL1 OPRK1 OPRD1
9 opioid receptor activity GO:0004985 8.92 OPRM1 OPRL1 OPRK1 OPRD1

Sources for Morphine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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