MCID: MRP001
MIFTS: 38

Morphine Dependence

Categories: Mental diseases

Aliases & Classifications for Morphine Dependence

MalaCards integrated aliases for Morphine Dependence:

Name: Morphine Dependence 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2560
MeSH 44 D009021
UMLS 73 C0026552

Summaries for Morphine Dependence

Disease Ontology : 12 An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.

MalaCards based summary : Morphine Dependence is related to withdrawal disorder and heroin dependence. An important gene associated with Morphine Dependence is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cytokine Signaling in Immune system. The drugs Clonidine and Morphine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Morphine Dependence

Diseases related to Morphine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 withdrawal disorder 30.3 FOS OPRM1
2 heroin dependence 29.9 OPRD1 OPRM1
3 opiate dependence 29.5 CREB1 OPRD1 OPRK1 OPRM1
4 opioid abuse 10.1 CCK OPRM1
5 neonatal abstinence syndrome 10.1 OPRD1 OPRK1 OPRM1
6 cocaine dependence 10.1 OPRD1 OPRK1 OPRM1
7 drug dependence 10.1 OPRD1 OPRK1 OPRM1
8 substance dependence 10.1 OPRD1 OPRK1 OPRM1
9 bile reflux 10.1 CCK PTGS2
10 aspirin resistance 10.0 PTGS1 PTGS2
11 active peptic ulcer disease 10.0 PTGS1 PTGS2
12 anxiety 10.0
13 opioid addiction 10.0 CCK OPRD1 OPRK1 OPRM1
14 functional gastric disease 10.0 CCK TRPV1
15 ocular dominance 10.0 CREB1 GRIN1
16 alcohol dependence 10.0 CCK OPRD1 OPRK1 OPRM1
17 specific developmental disorder 9.9 CCK OPRM1 TRPV1
18 hydrops, lactic acidosis, and sideroblastic anemia 9.9 ALOX5 PTGS1 PTGS2
19 proteasome-associated autoinflammatory syndrome 1 9.9 ALOX5 PTGS1 PTGS2
20 cerebral hypoxia 9.9 CREB1 FOS
21 space motion sickness 9.9 CCK FOS
22 gastrointestinal system disease 9.8 CCK PTGS2 TRPV1
23 stomach disease 9.8 PTGS1 PTGS2 TRPV1
24 neuroblastoma 9.8
25 aging 9.8
26 depression 9.8
27 dyspepsia 9.7 CCK PTGS1 PTGS2 TRPV1
28 gastroesophageal reflux 9.7 CCK PTGS1 PTGS2 TRPV1
29 coffin-lowry syndrome 9.7 CREB1 FOS
30 disease of mental health 9.7 CCK FOS OPRM1 TRPV1
31 pain agnosia 9.6 CCK FOS OPRK1 OPRM1 TRPV1
32 agnosia 9.6 CCK FOS OPRK1 OPRM1 TRPV1
33 inflammatory bowel disease 9.5 ALOX5 PTGS1 PTGS2 TRPV1

Graphical network of the top 20 diseases related to Morphine Dependence:



Diseases related to Morphine Dependence

Symptoms & Phenotypes for Morphine Dependence

MGI Mouse Phenotypes related to Morphine Dependence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 CCK CREB1 FOS GRIN1 OPRD1 OPRK1
2 homeostasis/metabolism MP:0005376 10.1 ADCY10 ALOX5 CCK CREB1 FOS GRIN1
3 cellular MP:0005384 10.06 ADCY10 ALOX5 CREB1 FOS GRIN1 OPRM1
4 cardiovascular system MP:0005385 9.98 ADCY10 ALOX5 CREB1 GRIN1 PTGS1 PTGS2
5 endocrine/exocrine gland MP:0005379 9.91 CCK CREB1 FOS OPRK1 OPRM1 PTGS1
6 nervous system MP:0003631 9.85 CCK CREB1 FOS GRIN1 OPRD1 OPRK1
7 integument MP:0010771 9.8 FOS OPRD1 OPRK1 OPRM1 PTGS1 PTGS2
8 no phenotypic analysis MP:0003012 9.5 ADCY10 CCK GRIN1 OPRD1 OPRM1 PTGS2
9 reproductive system MP:0005389 9.23 ADCY10 CREB1 FOS GRIN1 OPRK1 OPRM1

Drugs & Therapeutics for Morphine Dependence

Drugs for Morphine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 3 4205-90-7 2803
2
Morphine Approved, Investigational Phase 3 57-27-2 5288826
3
Naloxone Approved, Vet_approved Phase 3 465-65-6 5284596
4
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
5 Buprenorphine, Naloxone Drug Combination Phase 3
6 Antihypertensive Agents Phase 3
7 Adrenergic Agonists Phase 3
8 Analgesics, Opioid Phase 3
9 Adrenergic alpha-Agonists Phase 3
10 Opiate Alkaloids Phase 3
11 Analgesics Phase 3
12 Central Nervous System Depressants Phase 3
13 Sympatholytics Phase 3
14 Narcotic Antagonists Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Adrenergic alpha-2 Receptor Agonists Phase 3
17 Autonomic Agents Phase 3
18 Narcotics Phase 3
19 Neurotransmitter Agents Phase 3
20 Adrenergic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1 Completed NCT00032955 Phase 3 Buprenorphine/naloxone
2 Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1 Completed NCT00032968 Phase 3 Buprenorphine/naloxone

Search NIH Clinical Center for Morphine Dependence

Cochrane evidence based reviews: morphine dependence

Genetic Tests for Morphine Dependence

Anatomical Context for Morphine Dependence

MalaCards organs/tissues related to Morphine Dependence:

41
Brain, Cortex, Spinal Cord, Hypothalamus, Kidney, Prefrontal Cortex, Caudate Nucleus

Publications for Morphine Dependence

Articles related to Morphine Dependence:

(show top 50) (show all 243)
# Title Authors Year
1
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. ( 29483538 )
2018
2
Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways. ( 29223784 )
2018
3
Naloxone precipitated morphine withdrawal and clock genes expression in striatum: A comparative study in three different protocols for the development of morphine dependence. ( 30030165 )
2018
4
Over-expression of CCK1 Receptor Reverse Morphine Dependence. ( 30147637 )
2018
5
Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes. ( 30227624 )
2018
6
The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. ( 30258112 )
2018
7
Chromium picolinate reduces morphine-dependence in rats, while increasing brain serotonin levels. ( 30269760 )
2018
8
Inhibiting social support from massage-like stroking increases morphine dependence. ( 29049082 )
2017
9
Prevention of morphine dependence and tolerance by Nepeta menthoides was accompanied by attenuation of Nitric oxide overproduction in male mice. ( 28130112 )
2017
10
Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons. ( 28888954 )
2017
11
Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. ( 28341892 )
2017
12
Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. ( 29116553 )
2017
13
Prolonged ventricular infusion of ginsenosides attenuated morphine dependence. ( 27976116 )
2016
14
Effect of Treadmill Running on Morphine Dependence Before and After Medial Prefrontal Cortex Lesion in Rats. ( 28144409 )
2016
15
Opioid agonist doses for oxycodone and morphine dependence: Findings from a retrospective case series. ( 27273511 )
2016
16
Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. ( 27618384 )
2016
17
Chronic administration of nandrolone increases susceptibility to morphine dependence without correlation with LVV-hemorphin 7 in rats. ( 27289274 )
2016
18
Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K. ( 27746699 )
2016
19
Integrated workflow for quantitative phosphoproteomic analysis of the selected brain structures in development of morphine dependence. ( 25443728 )
2014
20
NF-I_B signaling and vesicle transport are correlated with the reactivation of the memory trace of morphine dependence. ( 25012590 )
2014
21
Social housing conditions influence morphine dependence and the extinction of morphine place preference in adolescent mice. ( 25048393 )
2014
22
Morphine dependence in single enteric neurons from the mouse colon requires deletion of I^-arrestin2. ( 25194025 )
2014
23
Differential Changes in Expression of Stress- and Metabolic-Related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal. ( 23805290 )
2013
24
Pioglitazone potentiates development of morphine-dependence in mice: possible role of NO/cGMP pathway. ( 23399681 )
2013
25
Comparative proteomic analysis of the nucleus accumbens during extinction and reinstatement of morphine dependence. ( 24564042 )
2013
26
Involvement of hippocampal phosphatidylethanolamine-binding protein in morphine dependence and withdrawal. ( 21967037 )
2013
27
Morphine dependence and withdrawal induced changes in cholinergic signaling. ( 23651795 )
2013
28
Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. ( 23684726 )
2013
29
Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. ( 22682150 )
2012
30
Dopamine affects the change of pain-related electrical activity induced by morphine dependence. ( 22240902 )
2012
31
Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. ( 22040728 )
2012
32
Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence. ( 21967557 )
2012
33
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect. ( 24900506 )
2012
34
Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention. ( 22123079 )
2012
35
Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats. ( 23269899 )
2012
36
A^H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention. ( 22391120 )
2012
37
The effect of morphine dependence on impulsive choice in rats. ( 22588252 )
2012
38
Morphinome--a meta-analysis applied to proteomics studies in morphine dependence. ( 21182190 )
2011
39
Distribution of TRPC6 in the cerebrospinal fluid-contacting nucleus of rat brain parenchyma and its expression in morphine dependence and withdrawal. ( 21858483 )
2011
40
Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management. ( 21886595 )
2011
41
JWA regulates chronic morphine dependence via the delta opioid receptor. ( 21600884 )
2011
42
Role of calcium in morphine dependence and naloxone-precipitated withdrawal in mice. ( 27186105 )
2011
43
Participation of L-type voltage-gated calcium channels in facilitation of long-term potentiation during the formation of morphine dependence in rats. ( 21240373 )
2010
44
Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. ( 20438612 )
2010
45
Study of the intraplantar injection of lidocaine and morphine on pain perception and the influence of morphine dependence and withdrawal on lidocaine-induced analgesia in rats. ( 21283259 )
2010
46
Does exercise deprivation increase the tendency towards morphine dependence in rats? ( 24494104 )
2010
47
A role for the parafascicular thalamic nucleus in the development of morphine dependence and withdrawal. ( 19332040 )
2009
48
Relative potency of the opioid antagonists naloxone and 6-alpha-naloxol to precipitate withdrawal from acute morphine dependence varies with time post-antagonist. ( 19061911 )
2009
49
Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. ( 19183220 )
2009
50
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. ( 19356733 )
2009

Variations for Morphine Dependence

Expression for Morphine Dependence

Search GEO for disease gene expression data for Morphine Dependence.

Pathways for Morphine Dependence

Pathways related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 CCK GRIN1 OPRD1 OPRK1 OPRM1 TRPV1
2
Show member pathways
13.08 ALOX5 FOS GRIN1 OPRD1 OPRM1 PTGS2
3
Show member pathways
12.78 ADCY10 CREB1 FOS GRIN1 OPRM1
4
Show member pathways
12.76 CREB1 GRIN1 OPRM1 PTGS1 PTGS2 TRPV1
5
Show member pathways
12.55 CREB1 FOS OPRD1 PTGS2
6
Show member pathways
12.48 CREB1 FOS GRIN1 PTGS2
7 12.19 CREB1 GRIN1 OPRM1 PTGS1 PTGS2
8
Show member pathways
12.18 ALOX5 PTGS1 PTGS2
9
Show member pathways
12.17 CREB1 FOS PTGS1 PTGS2
10
Show member pathways
12.09 ALOX5 FOS PTGS2
11
Show member pathways
12.02 ALOX5 PTGS1 PTGS2
12
Show member pathways
12.01 ADCY10 CREB1 FOS GRIN1
13 11.95 CREB1 FOS GRIN1
14 11.82 FOS GRIN1 PTGS2
15
Show member pathways
11.8 CREB1 FOS GRIN1
16
Show member pathways
11.79 ALOX5 PTGS1 PTGS2
17 11.77 ALOX5 PTGS1 PTGS2
18 11.74 CREB1 FOS PTGS2
19 11.4 CREB1 GRIN1 OPRK1
20 11.21 CREB1 PTGS2
21 11.19 CREB1 GRIN1
22 11.17 CREB1 FOS
23 11.16 CREB1 TRPV1
24 11.12 PTGS1 PTGS2
25 11.08 PTGS1 PTGS2
26 11.08 ALOX5 FOS OPRD1 OPRM1 PTGS2
27
Show member pathways
10.99 CREB1 FOS TRPV1
28 10.98 CREB1 FOS
29 10.98 PTGS1 PTGS2
30 10.88 PTGS1 PTGS2
31 10.85 CREB1 FOS
32
Show member pathways
10.76 ALOX5 PTGS1 PTGS2
33 10.75 PTGS1 PTGS2
34 10.51 ALOX5 PTGS1 PTGS2
35
Show member pathways
10.23 ALOX5 PTGS2

GO Terms for Morphine Dependence

Cellular components related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.71 FOS GRIN1 PTGS2 TRPV1
2 neuronal cell body GO:0043025 9.67 ADCY10 CCK OPRK1 TRPV1
3 axon GO:0030424 9.56 ADCY10 CCK CREB1 OPRM1
4 perikaryon GO:0043204 9.5 CCK OPRK1 OPRM1
5 integral component of synaptic vesicle membrane GO:0030285 9.46 OPRD1 OPRK1
6 dendrite membrane GO:0032590 9.43 OPRD1 OPRM1
7 integral component of presynaptic membrane GO:0099056 9.33 OPRD1 OPRK1 OPRM1
8 dendrite GO:0030425 9.1 ADCY10 CCK GRIN1 OPRK1 OPRM1 TRPV1
9 spine apparatus GO:0097444 8.96 OPRD1 OPRM1

Biological processes related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 ALOX5 FOS PTGS1 PTGS2 TRPV1
2 aging GO:0007568 9.82 CREB1 FOS PTGS2
3 response to lipopolysaccharide GO:0032496 9.82 FOS OPRM1 PTGS2
4 cytokine-mediated signaling pathway GO:0019221 9.8 ALOX5 FOS OPRD1 OPRM1 PTGS2
5 response to ethanol GO:0045471 9.77 GRIN1 OPRK1 OPRM1
6 neuropeptide signaling pathway GO:0007218 9.77 OPRD1 OPRK1 OPRM1
7 excitatory postsynaptic potential GO:0060079 9.74 GRIN1 OPRM1 TRPV1
8 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.73 OPRD1 OPRK1 OPRM1
9 positive regulation of apoptotic process GO:0043065 9.73 ADCY10 CCK CREB1 GRIN1 PTGS2 TRPV1
10 cellular response to growth factor stimulus GO:0071363 9.72 CREB1 OPRD1 TRPV1
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.7 OPRD1 OPRK1 OPRM1
12 visual learning GO:0008542 9.69 CCK CREB1 GRIN1
13 response to radiation GO:0009314 9.67 OPRK1 OPRM1 PTGS2
14 memory GO:0007613 9.67 CCK CREB1 GRIN1 PTGS2
15 cellular response to nerve growth factor stimulus GO:1990090 9.65 CREB1 TRPV1
16 response to organonitrogen compound GO:0010243 9.65 PTGS2 TRPV1
17 long-chain fatty acid biosynthetic process GO:0042759 9.64 ALOX5 PTGS2
18 prostaglandin metabolic process GO:0006693 9.63 PTGS1 PTGS2
19 positive regulation of osteoclast differentiation GO:0045672 9.63 CREB1 FOS
20 cellular response to ATP GO:0071318 9.62 PTGS2 TRPV1
21 estrous cycle GO:0044849 9.62 OPRK1 OPRM1
22 prostaglandin biosynthetic process GO:0001516 9.61 PTGS1 PTGS2
23 lipoxygenase pathway GO:0019372 9.61 ALOX5 PTGS2
24 response to morphine GO:0043278 9.61 GRIN1 OPRK1 OPRM1
25 cyclooxygenase pathway GO:0019371 9.58 PTGS1 PTGS2
26 sensory perception GO:0007600 9.58 OPRK1 OPRM1
27 conditioned taste aversion GO:0001661 9.54 FOS GRIN1
28 opioid receptor signaling pathway GO:0038003 9.5 OPRD1 OPRK1 OPRM1
29 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.46 OPRK1 OPRM1
30 regulation of sensory perception of pain GO:0051930 9.46 CCK OPRD1 OPRK1 OPRM1
31 eating behavior GO:0042755 9.26 CCK OPRD1 OPRK1 OPRM1
32 sensory perception of pain GO:0019233 9.02 GRIN1 OPRK1 OPRM1 PTGS2 TRPV1

Molecular functions related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.5 ALOX5 PTGS1 PTGS2
2 peroxidase activity GO:0004601 9.43 PTGS1 PTGS2
3 cation channel activity GO:0005261 9.4 GRIN1 TRPV1
4 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 9.37 ALOX5 PTGS2
5 receptor serine/threonine kinase binding GO:0033612 9.26 OPRD1 OPRK1
6 prostaglandin-endoperoxide synthase activity GO:0004666 9.16 PTGS1 PTGS2
7 neuropeptide binding GO:0042923 9.13 OPRD1 OPRK1 OPRM1
8 opioid receptor activity GO:0004985 8.8 OPRD1 OPRK1 OPRM1

Sources for Morphine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....