MCID: MRP001
MIFTS: 41

Morphine Dependence

Categories: Mental diseases

Aliases & Classifications for Morphine Dependence

MalaCards integrated aliases for Morphine Dependence:

Name: Morphine Dependence 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2560
MeSH 43 D009021
SNOMED-CT 67 231479000
UMLS 71 C0026552

Summaries for Morphine Dependence

Disease Ontology : 12 An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance.

MalaCards based summary : Morphine Dependence is related to opioid addiction and diarrhea. An important gene associated with Morphine Dependence is OPRK1 (Opioid Receptor Kappa 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Clonidine and Naloxone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Morphine Dependence

Diseases related to Morphine Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 opioid addiction 30.8 OPRM1 OPRK1 OPRD1 CCK
2 diarrhea 30.6 OPRM1 OPRK1 OPRD1 CCK
3 heroin dependence 29.9 PDYN OPRM1 OPRD1
4 pertussis 29.6 OPRM1 FOS ADCY10
5 withdrawal disorder 29.3 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
6 drug dependence 29.1 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
7 opioid abuse 29.0 PENK PDYN OPRM1 OPRL1 OPRK1 OPRD1
8 substance abuse 29.0 PDYN OPRM1 OPRL1 OPRK1 OPRD1 CRH
9 pain agnosia 28.4 PENK PDYN OXT OPRM1 OPRL1 OPRK1
10 sleep disorder 28.4 TH HCRTR1 HCRT FOS
11 constipation 28.1 TH PTGS1 PDYN OPRM1 OPRL1 OPRK1
12 opiate dependence 27.7 TH PENK PDYN OPRM1 OPRL1 OPRK1
13 anxiety 26.9 TH PDYN OXT OPRM1 OPRL1 OPRK1
14 ptosis 10.4
15 tremor 10.4
16 cerebral hypoxia 10.2 FOS CREB1
17 myasthenic syndrome, congenital, 1a, slow-channel 10.2 OXT OPRM1
18 barbiturate abuse 10.2 OPRM1 HCRT
19 trigeminal nerve disease 10.1 OPRM1 OPRL1 OPRK1 OPRD1
20 trigeminal neuralgia 10.1 OPRM1 OPRL1 OPRK1 OPRD1
21 somatization disorder 10.1 OXT CRH
22 cocaine dependence 10.1 PDYN OPRM1 OPRK1 OPRD1
23 rohhad 10.0 HCRTR1 HCRT
24 chronic pain 10.0
25 schaaf-yang syndrome 10.0 OPRM1 OPRL1 OPRD1 FOS
26 ileus 10.0 OPRM1 CRH CCK
27 retrograde amnesia 10.0 PDYN FOS CREB1
28 ocular dominance 10.0 GRIN1 CREB1
29 somatoform disorder 10.0 OPRM1 OPRL1 CRH
30 bulimia nervosa 10.0 OXT CRH CCK
31 status epilepticus 9.9 SLC1A2 GRIN1 FOS
32 fibromyalgia 9.9 OPRM1 OPRK1 OPRD1 CRH
33 cholera 9.9
34 glioblastoma multiforme 9.9
35 neuroblastoma 9.9
36 48,xyyy 9.9
37 mental depression 9.9 OXT CRH CREB1
38 spinocerebellar ataxia 23 9.9 PDYN OPRM1 OPRL1 OPRK1 OPRD1
39 neonatal abstinence syndrome 9.9 PDYN OPRM1 OPRL1 OPRK1 OPRD1
40 temporal lobe epilepsy 9.8 SLC1A2 PDYN OPRM1 GRIN1
41 von economo's disease 9.8 HCRTR1 HCRT FOS
42 irritable bowel syndrome 9.8 OPRM1 FOS CRH CCK
43 alcohol use disorder 9.8 OPRM1 CRH CREB1
44 kagami-ogata syndrome 9.8 OXT FOS CRH
45 childhood absence epilepsy 9.8 SLC1A2 PDYN OPRM1 FOS
46 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 9.8 TH CCK
47 aminopterin syndrome sine aminopterin 9.7
48 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.7
49 sexual disorder 9.7
50 visual epilepsy 9.7

Graphical network of the top 20 diseases related to Morphine Dependence:



Diseases related to Morphine Dependence

Symptoms & Phenotypes for Morphine Dependence

MGI Mouse Phenotypes related to Morphine Dependence:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 CREB1 CRH FOS GRIN1 HCRT HCRTR1
2 homeostasis/metabolism MP:0005376 10.3 ADCY10 CCK CREB1 CRH FOS GRIN1
3 growth/size/body region MP:0005378 10.18 CREB1 CRH FOS GRIN1 HCRT OPRM1
4 nervous system MP:0003631 10.16 CCK CREB1 CRH FOS GRIN1 HCRT
5 endocrine/exocrine gland MP:0005379 10.13 CCK CREB1 CRH FOS OPRK1 OPRM1
6 integument MP:0010771 10.06 CRH FOS OPRD1 OPRK1 OPRL1 OPRM1
7 no phenotypic analysis MP:0003012 9.81 ADCY10 CCK CRH GRIN1 OPRD1 OPRM1
8 normal MP:0002873 9.61 CREB1 CRH FOS GRIN1 OPRL1 OPRM1
9 reproductive system MP:0005389 9.28 ADCY10 CREB1 FOS GRIN1 OPRK1 OPRM1

Drugs & Therapeutics for Morphine Dependence

Drugs for Morphine Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 3 4205-90-7 2803
2
Naloxone Approved, Vet_approved Phase 3 465-65-6 5284596
3
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
4
Morphine Approved, Investigational Phase 3 57-27-2 5288826
5 Narcotics Phase 3
6 Opiate Alkaloids Phase 3
7 Analgesics, Opioid Phase 3
8 Analgesics Phase 3
9 Narcotic Antagonists Phase 3
10 Buprenorphine, Naloxone Drug Combination Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Buprenorphine/Naloxone Versus Clonidine For Out-patient Opiate Detoxification Completed NCT00032968 Phase 3 Buprenorphine/naloxone
2 Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification Completed NCT00032955 Phase 3 Buprenorphine/naloxone

Search NIH Clinical Center for Morphine Dependence

Cochrane evidence based reviews: morphine dependence

Genetic Tests for Morphine Dependence

Anatomical Context for Morphine Dependence

MalaCards organs/tissues related to Morphine Dependence:

40
Brain, Spinal Cord, Cortex, Hypothalamus, Heart, Amygdala, Pituitary

Publications for Morphine Dependence

Articles related to Morphine Dependence:

(show top 50) (show all 716)
# Title Authors PMID Year
1
[Opioid receptors altered binding nature in guinea-pig brain following the development of morphine dependence]. 54 61
8544279 1995
2
Inhibition of orexin receptor 1 contributes to the development of morphine dependence via attenuation of cAMP response element-binding protein and phospholipase Cβ3. 61
32404265 2020
3
Impairment of cost-benefit decision making in morphine-dependent rats is partly mediated via the alteration of BDNF and p-CREB levels in the nucleus accumbens. 61
32428531 2020
4
Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence. 61
32114118 2020
5
Fluoride Affects Dopamine Metabolism and Causes Changes in the Expression of Dopamine Receptors (D1R and D2R) in Chosen Brain Structures of Morphine-Dependent Rats. 61
32235357 2020
6
Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice. 61
31544297 2020
7
Venlafaxine inhibits naloxone-precipitated morphine withdrawal symptoms: Role of inflammatory cytokines and nitric oxide. 61
31630319 2020
8
Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1. 61
32153403 2020
9
Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats. 61
31424230 2019
10
Age- and sex-related changes in the severity of physical and psychological dependence in morphine-dependent rats. 61
31639387 2019
11
The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence. 61
31998461 2019
12
Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats. 61
31051222 2019
13
Dezocine Alleviates Morphine-Induced Dependence in Rats. 61
31094808 2019
14
The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence. 61
30902386 2019
15
Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor. 61
30584942 2019
16
Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats. 61
30632088 2019
17
Fluoxetine increases analgesic effects of morphine, prevents development of morphine tolerance and dependence through the modulation of L-type calcium channels expression in mice. 61
30550947 2019
18
The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice. 61
30689982 2019
19
Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence. 61
30634592 2019
20
Selection and Validation of Reference Genes for RT-PCR Expression Analysis of Candidate Genes Involved in Morphine-Induced Conditioned Place Preference Mice. 61
30386959 2018
21
Chromium picolinate reduces morphine-dependence in rats, while increasing brain serotonin levels. 61
30269760 2018
22
The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. 61
30258112 2018
23
Modulation of miR-139-5p on chronic morphine-induced, naloxone-precipitated cAMP overshoot in vitro. 61
29916183 2018
24
Naloxone precipitated morphine withdrawal and clock genes expression in striatum: A comparative study in three different protocols for the development of morphine dependence. 61
30030165 2018
25
Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes. 61
30227624 2018
26
The effect of metformin on morphine analgesic tolerance and dependence in rats. 61
30065764 2018
27
Magnesium in addiction - a general view. 61
30714574 2018
28
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. 61
29859324 2018
29
Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice. 61
29939746 2018
30
Hippocampal glial cells modulate morphine-induced behavioral responses. 61
29626506 2018
31
Effects of Clavulanic Acid on the Acquisition and Reinstatement Following Morphine-induced Conditioned Place Preference in Mice. 61
30519387 2018
32
Effect of Yulangsan Polysaccharide on the Reinstatement of Morphine-Induced Conditioned Place Preference in Sprague-Dawley Rats. 61
29455417 2018
33
Hyperbaric Oxygen Attenuates Withdrawal Symptoms by Regulating Monoaminergic Neurotransmitters and NO Signaling Pathway at Nucleus Accumbens in Morphine-Dependent Rats. 61
29313212 2018
34
Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways. 61
29223784 2018
35
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. 61
29483538 2018
36
Over-expression of CCK1 Receptor Reverse Morphine Dependence. 61
30147637 2018
37
Agmatine inhibits chronic morphine exposure-induced impairment of hippocampal neural progenitor proliferation in adult rats. 61
29031903 2018
38
The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. 61
28782589 2018
39
Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats. 61
28933310 2018
40
Proteomic Data in Morphine Addiction Versus Real Protein Activity: Metabolic Enzymes. 61
28430368 2017
41
Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). 61
28986608 2017
42
Inhibiting social support from massage-like stroking increases morphine dependence. 61
29049082 2017
43
Effect of Sinomenine on the Morphine-Dependence and Related Neural Mechanisms in Mice. 61
29116553 2017
44
Experimental Research Showing the Reduction of Naloxone-Place Aversion by Oral Zinc Administration in Rats. 61
28337700 2017
45
Central antagonism of orexin type-1 receptors attenuates the development of morphine dependence in rat locus coeruleus neurons. 61
28888954 2017
46
Maternal swimming exercise during pregnancy attenuates anxiety/depressive-like behaviors and voluntary morphine consumption in the pubertal male and female rat offspring born from morphine dependent mothers. 61
28867589 2017
47
Simvastatin prevents morphine-induced tolerance and dependence in mice. 61
28654797 2017
48
Antagonism of orexin type-1 receptors (OX1Rs) attenuates naloxone-precipitated morphine withdrawal syndrome in rat dorsal hippocampus. 61
28583577 2017
49
Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus-pituitary-adrenal axis dysfunction. 61
27618384 2017
50
Opioid agonist doses for oxycodone and morphine dependence: Findings from a retrospective case series. 61
27273511 2017

Variations for Morphine Dependence

Expression for Morphine Dependence

Search GEO for disease gene expression data for Morphine Dependence.

Pathways for Morphine Dependence

Pathways related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 PENK PDYN OXT OPRM1 OPRL1 OPRK1
2
Show member pathways
12.68 PENK PDYN OXT OPRM1 OPRL1 OPRK1
3
Show member pathways
12.55 TH SLC1A2 GRIN1 FOS CREB1 ADCY10
4
Show member pathways
12.32 PDYN OPRM1 CREB1 CCT6A
5
Show member pathways
12.3 OXT FOS CRH CREB1
6 12.1 OXT GRIN1 FOS CREB1 ADCY10
8 12.03 TH SLC1A2 PTGS1 OPRM1 HCRT GRIN1
9 11.81 PDYN GRIN1 FOS
10 11.77 OPRM1 OPRD1 FOS
11 11.64 FOS CRH CREB1
12
Show member pathways
11.63 TH PDYN GRIN1 FOS CREB1
13
Show member pathways
11.61 PDYN GRIN1 CREB1
14 11.43 OPRK1 GRIN1 CREB1
15 11.35 TH FOS CREB1
16 10.87 TH CREB1
17 10.8 FOS CREB1

GO Terms for Morphine Dependence

Cellular components related to Morphine Dependence according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 10.04 SLC1A2 OPRM1 OPRL1 OPRK1 OPRD1 HCRTR1
2 cell GO:0005623 10.02 TH OXT OPRL1 OPRK1 HCRTR1 HCRT
3 neuron projection GO:0043005 9.87 TH OPRM1 OPRL1 OPRK1 OPRD1 GRIN1
4 neuronal cell body GO:0043025 9.8 TH PENK PDYN OPRK1 CRH CCK
5 axon terminus GO:0043679 9.73 PENK PDYN OPRK1 OPRD1
6 integral component of presynaptic membrane GO:0099056 9.71 SLC1A2 OPRM1 OPRK1 OPRD1
7 axon GO:0030424 9.7 TH SLC1A2 PENK OPRM1 CREB1 CCK
8 terminal bouton GO:0043195 9.67 TH OXT GRIN1 CCK
9 spine apparatus GO:0097444 9.46 OPRM1 OPRD1
10 perikaryon GO:0043204 9.43 TH PENK OPRM1 OPRK1 CRH CCK
11 dendrite GO:0030425 9.23 TH PENK PDYN OPRM1 OPRK1 GRIN1

Biological processes related to Morphine Dependence according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 PENK OXT OPRM1 OPRL1 OPRK1 OPRD1
2 G protein-coupled receptor signaling pathway GO:0007186 10.11 PENK PDYN OXT OPRM1 OPRL1 OPRK1
3 response to drug GO:0042493 10.04 TH SLC1A2 FOS CRH CREB1
4 response to lipopolysaccharide GO:0032496 9.97 TH PENK OPRM1 FOS
5 response to estradiol GO:0032355 9.92 TH PENK OXT OPRL1
6 chemical synaptic transmission GO:0007268 9.92 SLC1A2 PENK PDYN OPRK1 HCRTR1 HCRT
7 response to ethanol GO:0045471 9.91 TH PENK OPRM1 OPRK1 GRIN1 CRH
8 locomotory behavior GO:0007626 9.9 TH PENK OPRM1 OPRK1
9 response to organic cyclic compound GO:0014070 9.89 TH OXT FOS
10 memory GO:0007613 9.89 TH OXT GRIN1 CREB1 CCK
11 female pregnancy GO:0007565 9.87 OXT FOS CRH
12 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.87 OPRM1 OPRK1 OPRD1 HCRT
13 cellular response to growth factor stimulus GO:0071363 9.86 TH OPRD1 CREB1
14 excitatory postsynaptic potential GO:0060079 9.86 OPRM1 HCRT GRIN1
15 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.86 OPRM1 OPRL1 OPRK1 OPRD1
16 social behavior GO:0035176 9.85 TH OXT GRIN1
17 sensory perception of pain GO:0019233 9.85 PENK OPRM1 OPRL1 OPRK1 GRIN1
18 visual learning GO:0008542 9.84 GRIN1 CREB1 CCK
19 response to cocaine GO:0042220 9.84 OXT OPRM1 OPRK1 CRH
20 response to activity GO:0014823 9.83 TH OXT CREB1
21 response to nicotine GO:0035094 9.83 TH PENK CREB1
22 response to radiation GO:0009314 9.83 PENK OPRM1 OPRK1
23 response to amphetamine GO:0001975 9.82 TH OXT GRIN1
24 regulation of NMDA receptor activity GO:2000310 9.81 OPRM1 GRIN1 CRH
25 response to morphine GO:0043278 9.81 PENK OPRM1 OPRK1 GRIN1
26 response to light stimulus GO:0009416 9.8 TH SLC1A2 FOS
27 response to immobilization stress GO:0035902 9.78 TH FOS CRH
28 response to corticosterone GO:0051412 9.76 TH FOS CRH
29 estrous cycle GO:0044849 9.75 OPRM1 OPRL1 OPRK1
30 sleep GO:0030431 9.72 OXT HCRT FOS
31 cellular response to extracellular stimulus GO:0031668 9.71 SLC1A2 FOS
32 synaptic transmission, dopaminergic GO:0001963 9.71 TH CRH
33 multicellular organism aging GO:0010259 9.71 TH SLC1A2
34 opioid receptor signaling pathway GO:0038003 9.71 OPRM1 OPRL1 OPRK1 OPRD1
35 startle response GO:0001964 9.7 PENK GRIN1
36 response to growth factor GO:0070848 9.7 TH OPRM1
37 behavior GO:0007610 9.7 OPRL1 OPRK1
38 positive regulation of behavioral fear response GO:2000987 9.7 PENK CRH CCK
39 maternal behavior GO:0042711 9.69 OXT OPRK1
40 locomotory exploration behavior GO:0035641 9.69 PENK CRH
41 positive regulation of sensory perception of pain GO:1904058 9.68 OPRL1 CCK
42 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.68 OPRM1 OPRL1
43 male mating behavior GO:0060179 9.68 OXT GRIN1
44 conditioned taste aversion GO:0001661 9.67 GRIN1 FOS
45 response to ether GO:0045472 9.65 TH OXT CRH
46 sensory perception GO:0007600 9.65 PENK PDYN OPRM1 OPRL1 OPRK1
47 negative regulation of luteinizing hormone secretion GO:0033685 9.64 OPRK1 CRH
48 regulation of sensory perception of pain GO:0051930 9.63 OXT OPRM1 OPRL1 OPRK1 OPRD1 CCK
49 conditioned place preference GO:1990708 9.62 OPRL1 OPRK1
50 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.61 OPRM1 OPRK1

Molecular functions related to Morphine Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 OXT CRH CCK
2 neuropeptide binding GO:0042923 9.56 OPRM1 OPRL1 OPRK1 OPRD1
3 peptide binding GO:0042277 9.55 OPRM1 OPRL1 OPRK1 OPRD1 HCRTR1
4 receptor serine/threonine kinase binding GO:0033612 9.4 OPRK1 OPRD1
5 opioid receptor binding GO:0031628 9.37 PENK PDYN
6 opioid peptide activity GO:0001515 9.32 PENK PDYN
7 opioid receptor activity GO:0004985 9.26 OPRM1 OPRL1 OPRK1 OPRD1
8 neuropeptide hormone activity GO:0005184 9.02 PENK OXT HCRT CRH CCK

Sources for Morphine Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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