MCID: MTL001
MIFTS: 13

Motility-Related Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Motility-Related Diarrhea

MalaCards integrated aliases for Motility-Related Diarrhea:

Name: Motility-Related Diarrhea 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050131

Summaries for Motility-Related Diarrhea

Disease Ontology : 12 Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.

MalaCards based summary : Motility-Related Diarrhea is related to diarrhea and diarrhea 1, secretory chloride, congenital. An important gene associated with Motility-Related Diarrhea is PDZD3 (PDZ Domain Containing 3). Related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Motility-Related Diarrhea

Diseases related to Motility-Related Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diarrhea 11.4
2 diarrhea 1, secretory chloride, congenital 9.5 SLC9A2 SLC26A6 PDZD3
3 osmotic diarrhea 9.5 SLC9A2 GUCA2A
4 inflammatory diarrhea 9.5 SLC9A2 SLC26A6 PDZD3
5 secretory diarrhea 9.3 SLC9A2 PDZD3 GUCA2A

Graphical network of the top 20 diseases related to Motility-Related Diarrhea:



Diseases related to Motility-Related Diarrhea

Symptoms & Phenotypes for Motility-Related Diarrhea

MGI Mouse Phenotypes related to Motility-Related Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 GUCA2A KCNE3 SLC26A6 SLC9A2
2 endocrine/exocrine gland MP:0005379 9.02 GUCA2A KCNE3 SCG3 SLC26A6 SLC9A2

Drugs & Therapeutics for Motility-Related Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297

Search NIH Clinical Center for Motility-Related Diarrhea

Genetic Tests for Motility-Related Diarrhea

Anatomical Context for Motility-Related Diarrhea

Publications for Motility-Related Diarrhea

Variations for Motility-Related Diarrhea

Expression for Motility-Related Diarrhea

Search GEO for disease gene expression data for Motility-Related Diarrhea.

Pathways for Motility-Related Diarrhea

GO Terms for Motility-Related Diarrhea

Cellular components related to Motility-Related Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.62 SLC26A6 KCNE3

Biological processes related to Motility-Related Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transmembrane transport GO:0071805 9.26 SLC9A2 KCNE3
2 anion transmembrane transport GO:0098656 9.16 SLC9A2 SLC26A6
3 regulation of intracellular pH GO:0051453 8.96 SLC9A2 SLC26A6
4 ion transport GO:0006811 8.92 SLC9A2 SLC26A6 PDZD3 KCNE3

Molecular functions related to Motility-Related Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antiporter activity GO:0015297 8.62 SLC9A2 SLC26A6

Sources for Motility-Related Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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