Mouth Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MTH009 MIFTS: 56	Mouth Disease Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Mouth Disease

MalaCards integrated aliases for Mouth Disease:

Name: Mouth Disease ¹² ¹⁵ ¹⁷

Mouth Diseases ⁴³ ⁷¹

Mouth Disorders ⁴²

Classifications:

MalaCards categories:
Anatomical: Oral diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:403

MeSH ⁴³ D009059

NCIt ⁴⁹ C3240

SNOMED-CT ⁶⁷ 118938008

EFO ¹⁷ EFO_1001047

UMLS ⁷¹ C0026636

Sources

Summaries for Mouth Disease

MedlinePlus : ⁴² Your mouth is one of the most important parts of your body. It has many different functions. It allows you to Take in food and drink Breathe in air Start digestion, with your teeth chewing the food you eat and your salivary glands releasing saliva to help break down the food Speak and sing Show emotion, by smiling or pouting Any problem that affects your mouth can make it hard to eat, drink, or even smile. Some common mouth problems include Cold sores - painful sores on the lips and around the mouth, caused by a virus Canker sores - painful sores in the mouth, caused by bacteria or viruses Thrush - a yeast infection that causes white patches in your mouth Leukoplakia - white patches of excess cell growth on the cheeks, gums or tongue, common in smokers Dry mouth - a lack of enough saliva, caused by some medicines and certain diseases Gum or tooth problems Bad breath Treatment for mouth disorders varies, depending on the problem. If a mouth problem is caused by some other disease, treating that disease can help. It is also important to keep your mouth clean and healthy by brushing, flossing, and not using tobacco.

MalaCards based summary : Mouth Disease, also known as mouth diseases, is related to hand, foot and mouth disease and exanthem, and has symptoms including tinnitus, snoring and halitosis. An important gene associated with Mouth Disease is G3BP1 (G3BP Stress Granule Assembly Factor 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Mannitol and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include mouth, testes and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : ¹² A gastrointestinal system disease that is located in the mouth.

Sources

Related Diseases for Mouth Disease

Diseases related to Mouth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 540)

#	Related Disease	Score	Top Affiliating Genes
1	hand, foot and mouth disease	35.2	VDR TLR7 TLR4 TLR3 SCARB2 IL6
2	exanthem	32.1	IL6 IL10 IFNG IFNA1 CRP
3	stomatitis	32.1	TLR4 IL6 IL10 IFNG IFNA1 DDX58
4	aseptic meningitis	32.0	SCARB2 IL10 IFNG CRP
5	encephalitis	31.8	TLR3 STAT1 IRF3 IL6 IL10 IFNA1
6	myocarditis	31.8	TLR4 TLR3 IL6 IL10 IFNG IFNA1
7	herpangina	31.8	TP53 TLR7 TLR4 TLR3 IRF3 IL6
8	poliomyelitis	31.7	SCARB2 IL10 IFNG EIF4G1
9	pulmonary edema	31.6	IL13 IL10 CRP
10	dermatitis	31.5	IL6 IL13 IL10 IFNG
11	vaccinia	31.5	TP53 STAT1 IRF3 IL6 IFNA1
12	rhinitis	31.4	TLR4 IL6 IL13 IL10 IFNG
13	viral infectious disease	31.4	TLR7 TLR4 TLR3 STAT1 IRF3 IL6
14	chickenpox	31.4	TLR3 STAT1 IL6 IL10 IFNG IFNA1
15	plague	31.4	TLR4 TLR3 IL6 IL10 DDX58
16	brucellosis	31.4	TLR4 IL6 IL13 IL10 IFNG CRP
17	erythema multiforme	31.3	IL6 IL13 IFNG
18	meningoencephalitis	31.3	TLR3 IL6 IL10 CRP
19	meningitis	31.3	TLR4 IL6 IL13 IL10 IFNG CRP
20	viral encephalitis	31.2	TLR3 IL6 IL10 IFNA1 DDX58
21	aphthous stomatitis	31.2	TLR4 IL6 IL10 IFNG
22	measles	31.2	TLR7 TLR4 TLR3 STAT1 IRF3 IL6
23	skin disease	31.2	VDR TP53 IL6 IL13 IL10 IFNG
24	respiratory failure	31.1	TLR4 IL6 IL13 IL10 CRP
25	hepatitis a	31.1	TLR4 TLR3 IL10 IFNG IFNA1
26	dermatitis, atopic	31.1	TLR4 TLR3 STAT1 IL6 IL13 IL10
27	avian influenza	31.1	IL6 IFNA1 DDX58
28	diarrhea	31.1	TLR4 STAT1 IRF3 IL6 IL13 IL10
29	rabies	31.0	TLR3 STAT1 IRF3 IFNA1 DDX58
30	pancreatitis	31.0	TP53 IL6 IL10 CRP
31	trypanosomiasis	31.0	TLR4 IL6 IL10 IFNG
32	venezuelan equine encephalitis	31.0	STAT1 IFNG IFNA1
33	herpes simplex	31.0	TLR3 STAT1 IRF3 IL6 IFNA1 DDX58
34	japanese encephalitis	31.0	TLR7 TLR3 IFNA1
35	syphilis	31.0	IL6 IFNG CRP
36	chorioretinitis	30.9	IL6 IL10 IFNG
37	chlamydia	30.9	TLR4 IL6 IL10 IFNG CRP
38	endocarditis	30.9	IL6 IL10 IFNG CRP
39	tetanus	30.9	IL6 IL13 IL10 IFNG CRP
40	acute pancreatitis	30.9	TLR4 IL6 IL10 CRP
41	human immunodeficiency virus type 1	30.8	TLR3 STAT1 IRF3 IL10 IFNG
42	immune deficiency disease	30.8	VDR STAT1 IL6 IL13 IL10 IFNG
43	severe acute respiratory syndrome	30.8	STAT1 IRF3 IL6 IL10 IFNG IFNA1
44	influenza	30.8	TLR7 TLR4 TLR3 STAT1 IRF3 IL6
45	bronchopneumonia	30.7	TLR4 IL6 IL10 CRP
46	tick-borne encephalitis	30.7	TLR3 IL10 IFNA1 DDX58
47	acute myocarditis	30.7	TLR3 STAT1 IL10 CRP
48	appendicitis	30.7	TLR4 IL6 IL10 IFNG CRP
49	fasciitis	30.7	TP53 IL6 IFNG IFNA1 CRP
50	cellulitis	30.7	IL6 IL10 IFNG CRP

Graphical network of the top 20 diseases related to Mouth Disease:

Sources

Symptoms & Phenotypes for Mouth Disease

UMLS symptoms related to Mouth Disease:

tinnitus, snoring, halitosis, sore throat, coughing, vertigo/dizziness, equilibration disorder, oral manifestations

GenomeRNAi Phenotypes related to Mouth Disease according to GeneCards Suite gene sharing:

²⁶ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-113	9.62	TLR4
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-114	9.62	EIF4G1 TLR4
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-128	9.62	IL10
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-132	9.62	IL10
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-133	9.62	EIF4G1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-166	9.62	EIF4G1
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-169	9.62	TLR4
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	9.62	IL10
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-179	9.62	IL10
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-180	9.62	CRP
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-185	9.62	EIF4G1
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-25	9.62	IL10
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	9.62	IL10
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-38	9.62	EIF4G1
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-49	9.62	CRP
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-68	9.62	CRP
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-8	9.62	EIF4G1
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-80	9.62	IL10
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-89	9.62	CRP

MGI Mouse Phenotypes related to Mouth Disease:

⁴⁵ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.4	DDX58 IFNG IL10 IL13 IL17F IL6
2	immune system	MP:0005387	10.4	CRP DDX58 IFNG IL10 IL13 IL17F
3	cellular	MP:0005384	10.39	DDX58 G3BP1 IFNG IL10 IL13 IL6
4	homeostasis/metabolism	MP:0005376	10.39	CRP DDX58 IFNG IL10 IL13 IL6
5	cardiovascular system	MP:0005385	10.36	CRP G3BP1 IFNG IL10 IL6 NOTCH1
6	growth/size/body region	MP:0005378	10.36	DDX58 G3BP1 IFNG IL10 IL13 IL17F
7	mortality/aging	MP:0010768	10.34	DDX58 G3BP1 G3BP2 IFNG IL10 IL13
8	digestive/alimentary	MP:0005381	10.3	DDX58 IFNG IL10 IL13 IL17F IL6
9	integument	MP:0010771	10.13	IFNG IL10 IL13 IL6 NOTCH1 STAT1
10	craniofacial	MP:0005382	10.11	G3BP1 IFNG IL10 IL17F NOTCH1 TP53
11	muscle	MP:0005369	10.1	IFNG IL10 IL13 IL6 NOTCH1 STAT1
12	nervous system	MP:0003631	10.1	G3BP1 IFNG IL10 IL13 IL6 NOTCH1
13	liver/biliary system	MP:0005370	10.06	DDX58 IFNG IL10 IL6 NOTCH1 STAT1
14	neoplasm	MP:0002006	10.02	DDX58 IFNG IL10 IL6 NOTCH1 STAT1
15	hearing/vestibular/ear	MP:0005377	10.01	IL13 NOTCH1 SCARB2 TLR4 TP53 VDR
16	respiratory system	MP:0005388	9.93	G3BP1 IFNG IL10 IL13 IL17F IL6
17	renal/urinary system	MP:0005367	9.86	IFNG IL6 NOTCH1 SCARB2 TLR4 TLR7
18	skeleton	MP:0005390	9.7	IFNG IL10 IL13 IL17F IL6 NOTCH1
19	vision/eye	MP:0005391	9.28	G3BP1 IFNG IL10 IL6 IRF3 NOTCH1

Sources

Drugs & Therapeutics for Mouth Disease

Drugs for Mouth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mannitol

Approved, Investigational

Phase 4

69-65-8

6251 453

Ribavirin

Approved

Phase 4

36791-04-5

37542

Immunoglobulins, Intravenous

Phase 4

Antimetabolites

Phase 4

Antibodies, Blocking

Phase 4

Antibodies

Phase 4

Immunoglobulins

Phase 4

Vaccines

Phase 4

Immunologic Factors

Phase 4

Chlorhexidine

Approved, Vet_approved

Phase 3

55-56-1

9552079 2713

Hydroxychloroquine

Approved

Phase 2, Phase 3

118-42-3

3652

Chlorhexidine gluconate

Phase 3

Anti-Infective Agents, Local

Phase 3

Dermatologic Agents

Phase 3

Disinfectants

Phase 3

Antiviral Agents

Phase 2, Phase 3

Anti-Infective Agents

Phase 2, Phase 3

Antirheumatic Agents

Phase 2, Phase 3

Antiprotozoal Agents

Phase 2, Phase 3

Antiparasitic Agents

Phase 2, Phase 3

Antimalarials

Phase 2, Phase 3

Ibuprofen

Approved

Phase 2

15687-27-1

3672

Acetaminophen

Approved

Phase 2

103-90-2

1983

Sucralfate

Approved

Phase 2

54182-58-0

Aluminum hydroxide

Approved, Investigational

Phase 2

21645-51-2

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 2

7487-88-9

24083

Nicotine

Approved

Phase 1, Phase 2

54-11-5

942 89594

Aluminum sulfate

Approved

Phase 2

10043-01-3

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 2

22737-96-8, 68-26-8, 11103-57-4

9904001 445354

Lobeline

Investigational

Phase 2

90-69-7

Anti-Inflammatory Agents

Phase 2

Analgesics, Non-Narcotic

Phase 2

Antipyretics

Phase 2

Cyclooxygenase Inhibitors

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Gastrointestinal Agents

Phase 2

Hormones

Phase 2

Antacids

Phase 2

Anti-Ulcer Agents

Phase 2

Analgesics

Phase 2

Anesthetics

Phase 2

Retinol palmitate

Phase 2

retinol

Phase 2

Anti-Arrhythmia Agents

Phase 2

Tocolytic Agents

Phase 2

Anticonvulsants

Phase 2

Calcium, Dietary

Phase 2

calcium channel blockers

Phase 2

Adjuvants, Immunologic

Phase 2

Respiratory System Agents

Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 90)

#	Name	Status	NCT ID	Phase	Drugs
1	Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months	Unknown status	NCT02889497	Phase 4
2	The Safety and Immunogenicity of Enterovirus Type 71 Inactivated Vaccine (Human Diploid Cell) With Two Measles Attenuated Live Vaccine and Live Attenuated Japanese Encephalitis Vaccine at the Same Time Point in Infants (8-month-old)	Unknown status	NCT03296410	Phase 4
3	The Safety, Immune Persistence and Consistency of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17)	Unknown status	NCT02999828	Phase 4
4	Effect and Safety of Xiao'er Jiebiao Oral Liquid in Combination With Standard Treatment on Hand-foot-mouth Disease in Pediatric Patients	Completed	NCT02328651	Phase 4	Ribavirin plus Xiao'er jiebiao oral liquid;Ribavirin
5	A Opened，Randomized and Controlled Trial to Evaluate the Immunity and Safety of Sequential Vaccination of Two Different Commercial EV71 Inactived Vaccines in Healthy Infants Aged 6-35 Months	Completed	NCT03873740	Phase 4
6	A Phase IV Open-labelled, Single-centered, Stratified-randomized Clinical Trial in Zhejiang Province to Evaluate the Safety and Immunogenicity of EV71 Vaccine Developed by Sinovac Biotech Co., Ltd.	Completed	NCT03278132	Phase 4
7	A Randomized, Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With Recombinant Hepatitis B Vaccine/Group A Meningococcal Polysaccharide Vaccine	Completed	NCT03274102	Phase 4
8	Effectiveness and Safety of Inactivated EV71 Vaccine (Human Diploid Cell) in 6-71 Months Children: an Open-label Controlled Phase Ⅳ Clinical Study	Completed	NCT03001986	Phase 4
9	Peri-implantitis - Regenerative Treatment With Enamel Matrix Derivative (EMD). Clinical Effects, Microbial Profiles and Molecular Mechanisms. A Randomised Controlled Pilot Study.	Completed	NCT02500654	Phase 4
10	Multiple Centers, Randomized, and Control Trail on the Immunogenicity and Safety of the Simultaneously Vaccination of Inactivated Enterovirus 71 Vaccine (EV71) and Seasonal Influenza Vaccine(SIV)	Recruiting	NCT04133584	Phase 4
11	A Randomized, Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With Measles, Mumps, and Rubella Combined Live Attenuated Vaccine/ Encephalitis Live Attenuated Vaccine	Recruiting	NCT04111432	Phase 4
12	Study on Immunogenicity of Inactivated Enterovirus 71 (EV71) Vaccine (Human Diploid Cell, KMB-17) in Large-scale Healthy Children in China	Active, not recruiting	NCT03240744	Phase 4
13	Phase Ⅳ Clinical Trial, to Evaluate the Efficacy of the Enterovirus 71 (EV71) Inactivated Vaccine and Its Correlation With EV71 Antibody Level	Active, not recruiting	NCT03903926	Phase 4
14	A Phase IV Clinical Trial for Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71: A Multicenter， Case-control Study.	Enrolling by invitation	NCT03582761	Phase 4
15	Three Batches Consistency, Immunity Duration and Safety of Inactivated Enterovirus 71 Vaccine Post-marketing Among Children Aged 6-35 Months in China	Not yet recruiting	NCT03893747	Phase 4
16	A Comparison of Three Different Modalities in Improving Oral Hygiene in Adult Orthodontic Patients - A Randomized Controlled Trial	Not yet recruiting	NCT04386421	Phase 4	Plaque disclosing tablets
17	A Multicentered, Double - Blind, Randomized, and Placebo - Controlled Clinical Trial With Inactivated Enterovirus Type 71 (EV71) Vaccines	Completed	NCT01507857	Phase 3
18	A Multiple-center Randomized Double-blind Placebo-controlled Phase 3 Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months	Completed	NCT01508247	Phase 3
19	Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine: A Double-blind, Randomized and Controlled Trial	Completed	NCT01636245	Phase 3
20	A Phase III Clinical Trial With Randomized, Double-blinded, Controlled Design as Well as Bridging Design to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Children Aged 36-71 Months	Completed	NCT03909074	Phase 3
21	Multi-Center Phase 3 Trial of Chlorhexidine Gluconate Chip for the Use in Subjects With Peri-Implantitis.	Completed	NCT02080403	Phase 3	2.5 mg Chlorhexidine gluconate chip
22	A Phase III Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Infants and Children	Completed	NCT01569581	Phase 3
23	Treatment of Covid-19 With Favipiravir Versus Hydroxychloroquine: a Randomized Comparator Trial	Not yet recruiting	NCT04387760	Phase 2, Phase 3	Hydroxychloroquine;Favipiravir
24	Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial	Unknown status	NCT03241030	Phase 2	Sucralfate;Acetaminophen;Ibuprofen
25	An Open-Label, Dose-Finding, Phase II Study to Evaluate the Immunogenicity and Safety of the Bioreactor-generated EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 2 to 35 Months Old	Unknown status	NCT03268083	Phase 2
26	A Phase 2b, Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Three Different Doses of SCV 07 in Attenuating Oral Mucositis in Subjects With Head and Neck Cancer Receiving Concurrent Chemotherapy and Radiotherapy	Unknown status	NCT01247246	Phase 2	SCV-07;Placebo
27	Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling	Unknown status	NCT00228280	Phase 1, Phase 2
28	A Phase II Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Infants	Completed	NCT01512706	Phase 2
29	A Randomized, Placebo-controlled, Double-blind Trial of Intravenous Magnesium Sulfate for the Management of Severe Hand, Foot and Mouth Disease With Autonomic Nervous System Dysregulation in Vietnamese Children.	Completed	NCT01940250	Phase 2	Magnesium Sulphate;Sterile water
30	Phase II, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study of the Effects of RK-0202 on Oral Mucositis in Patients Receiving Radiation Therapy for Tumors of the Oral Cavity, Oropharynx, Nasopharynx, Salivary Glands or Supraglottic Region	Completed	NCT00230191	Phase 2	RK-0202
31	A Phase II Randomized Double Blind Placebo Controlled Trial to Assess Safety and Efficacy of Velafermin for Prevention of Oral Mucositis in Hematologic Cancer Patients Receiving Autologous Stem Cell Transplant	Completed	NCT00323518	Phase 2	velafermin;placebo
32	A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Safety and Efficacy of CG53135-05 Administered Intravenously as a Single Dose for the Prevention of Oral Mucositis in Patients Receiving Autologous Hematopoietic Stem Cell Transplant	Completed	NCT00104065	Phase 2	CG53135-05, velafermin
33	An Open-label, Dose-finding, Phase II Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 6 to 35 Months Old	Completed	NCT02777411	Phase 2
34	A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants	Completed	NCT01399853	Phase 2
35	Evaluation of the Clinical Effects of Tooth Powder on Plaque Induced Gingivitis	Completed	NCT01902095	Phase 2
36	A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children	Completed	NCT01734408	Phase 2
37	Treatment of Smokeless Tobacco Users	Completed	NCT00218270	Phase 2	Tobacco free snuff
38	Treatment of Smokeless Tobacco Users: Use of Nicotine Replacement Products to Reduce Smokeless Tobacco Use	Completed	NCT00218244	Phase 1, Phase 2
39	An Adaptive Phase 2 Randomized Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Multiple LOU064 Doses in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe)	Recruiting	NCT04035668	Phase 2	LOU064;Placebo
40	Intraoral Grafting of Ex Vivo Produced Oral Mucosal Composites	Unknown status	NCT00000111	Phase 1
41	Phase I, Double Blind, Randomized, Placebo-controlled, Dose Escalation Study to Assess the Safety and Immunogenicity of a Prophylactic Vaccine Against Enterovirus Infection in Healthy Adults	Completed	NCT01376479	Phase 1
42	A Phase Ia Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children	Completed	NCT01267903	Phase 1
43	A Blind, Randomized and Placebo-controlled Clinical Trial With Inactivated Enterovirus Type 71 Vaccines in Healthy Children.	Completed	NCT01273246	Phase 1
44	A Phase Ib Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants	Completed	NCT01313715	Phase 1
45	A Phase I Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Adults, Children and Infants	Completed	NCT01391494	Phase 1
46	Evaluation of Polarized Reflectance Spectroscopy for Detection of High-risk Oral Lesions	Completed	NCT01604759	Phase 1
47	A Randomized, Double-blind, Placebo-controlled, Phase 1 Clinical Trial to Investigate the Safety and Immunogenicity of CJ-40010 After Administration in Healthy Subjects	Recruiting	NCT04182932	Phase 1
48	A Randomized, Double-blind, Placebo-controlled, Single-dose, Dose-escalation Study to Evaluate the Tolerance and Pharmacokinetics of Suramin Sodium in Healthy Chinese Adults	Recruiting	NCT03804749	Phase 1	suramin sodium
49	Validation and Dosimetry Study of [18F]-FBA-A20FMDV2 PET Ligand for Alpha(V)beta6 in Healthy Subjects and in the Lungs of Idiopathic Pulmonary Fibrosis (IPF) Subjects (PETAL Study)	Terminated	NCT02052297	Phase 1
50	A Multi-Center Clinical Trial To Evaluate Chinese Herbal Medicines in the Treatment of Severe Hand-foot-mouth Disease	Unknown status	NCT01145664		Herbal concentrate-granules plus western therapy;Reduning Injection plus western therapy;Western therapy

Search NIH Clinical Center for Mouth Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Lidocaine

LIDOCAINE HCL PWDR

Lidocaine Hydrochloride

LIDOCAINE PWDR

Cochrane evidence based reviews: mouth diseases

Sources

Genetic Tests for Mouth Disease

Sources

Anatomical Context for Mouth Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Mouth Disease:

¹⁹

Mouth

MalaCards organs/tissues related to Mouth Disease:

⁴⁰

Testes, Kidney, T Cells, Tongue, Salivary Gland, B Cells, Skin

Sources

Publications for Mouth Disease

Articles related to Mouth Disease:

(show top 50) (show all 9581)

#	Title	Authors	PMID	Year
1	COVID-19: a novel coronavirus and a novel challenge for oral healthcare. ⁴²	Guo J...Wu H	32382932	2020
2	Radiotherapy-induced oral morbidities in head and neck cancer patients. ⁴²	Bhandari S...Ghoshal S	32378765	2020
3	Can Teledentistry Improve the Monitoring of Patients during the Covid-19 Dissemination? A Descriptive Pilot Study. ⁴²	Giudice A...Fortunato L	32414126	2020
4	Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. ⁶¹	You L...Wu J	32434419	2020
5	Exosomes cloak the virion to transmit Enterovirus 71 non-lytically. ⁶¹	Gu J...Mao L	31885311	2020
6	Epitope Peptide Amphiphile-Based Nanofiber as an Effective Vaccine for Viral Infectious Diseases. ⁶¹	Kim YG...Jin HE	32331099	2020
7	Transboundary Animal Diseases (TADs) affecting domestic and wild African ungulates: African swine fever, foot and mouth disease, Rift Valley fever (1996-2018). ⁶¹	Calkins CM...Scasta JD	32311588	2020
8	A new implication of quasispecies dynamics: Broad virus diversification in absence of external perturbations. ⁶¹	Domingo E...Perales C	32165244	2020
9	Quantifying the risk of hand, foot, and mouth disease (HFMD) attributable to meteorological factors in East China: A time series modelling study. ⁶¹	Qi H...Zhang Z	32361359	2020
10	Reduction of foot-and-mouth disease virus transmission in cattle vaccinated one or two weeks before challenge using a commercial polyvalent vaccine. ⁶¹	Duffy S...Monti G	32368734	2020
11	Virological investigation of genetic variation of enterovirus type 71 in hand, foot and mouth disease. ⁶¹	Wang Y...Gao H	32537012	2020
12	Capsid proteins of foot-and-mouth disease virus interact with TLR2 and CD14 to induce cytokine production. ⁶¹	Lin YT...Liang SM	32333963	2020
13	Soluble FMDV VP1 proteins fused with calreticulin expressed in Escherichia coli under the assist of trigger factor16 (Tf16) formed into high immunogenic polymers. ⁶¹	Liu C...Zhang G	31739054	2020
14	Acarbose, as a potential drug, effectively blocked the dynamic metastasis of EV71 from the intestine to the whole body. ⁶¹	Feng Q...Zheng Z	32004757	2020
15	Development and validation of a solid-phase competition ELISA based on virus-like particles of foot-and-mouth disease virus serotype A for antibody detection. ⁶¹	Zhang Y...Tian K	32350612	2020
16	Molecular characterisation of foot-and-mouth disease viruses circulating in Ethiopia between 2008 and 2019. ⁶¹	Gizaw D...King DP	32574400	2020
17	Development and serology based efficacy assessment of a trivalent foot-and-mouth disease vaccine. ⁶¹	Al Amin M...Hossain MA	32535015	2020
18	Foot-and-mouth disease virus induces PERK mediated autophagy to suppress antiviral interferon response. ⁶¹	Ranjitha HB...Basagoudanavar SH	32482793	2020
19	Enhanced protective immune response of foot-and-mouth disease vaccine through DNA-loaded virus-like particles. ⁶¹	Lu Y...Sun S	32165331	2020
20	Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China from 2008-2013. ⁶¹	Liu J...Qi J	32543714	2020
21	Influence of temperature and humidity on hand, foot, and mouth disease in Guangzhou, 2013-2017. ⁶¹	Chen C...Li T	32527174	2020
22	Vitamin D receptor gene methylation in patients with hand, foot, and mouth disease caused by enterovirus 71. ⁶¹	Li YP...Dang SS	32556549	2020
23	Immunomodulatory effects of platelets on the severity of hand, foot, and mouth disease infected with enterovirus 71. ⁶¹	Li Q...Guo W	32516798	2020
24	Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China: a time-series analysis. ⁶¹	Du Z...Hao Y	32530733	2020
25	Temperature and hand, foot and mouth disease in California: An exploratory analysis of emergency department visits by season, 2005-2013. ⁶¹	Pearson D...Ebisu K	32278924	2020
26	The Epidemiological and Clinical Characteristics of Hand, Foot, and Mouth Disease in Hangzhou, China, 2016 to 2018. ⁶¹	Wang J...Wu Y	32146823	2020
27	Seasonal Distribution and Meteorological Factors Associated with Hand, Foot, and Mouth Disease among Children in Xi'an, Northwestern China. ⁶¹	Guo T...Liu K	32157992	2020
28	Effect of heat-clearing and detoxifying Chinese medicines combined with conventional therapy on mild hand, foot, and mouth disease with fever: An individual patient data meta-analysis. ⁶¹	Yan S...Liu B	32501994	2020
29	Cellular Vimentin Interacts with Foot-and-Mouth Disease Virus Nonstructural Protein 3A and Negatively Modulates Viral Replication. ⁶¹	Ma X...Liu Z	32493819	2020
30	Spatiotemporal analyses of foot and mouth disease outbreaks in cattle farms in Chiang Mai and Lamphun, Thailand. ⁶¹	Arjkumpa O...Punyapornwithaya V	32487166	2020
31	Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice. ⁶¹	Nicolas MG...Paula M	32574690	2020
32	Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo. ⁶¹	Medina GN...de Los Santos T	32295921	2020
33	Application of median lethal concentration (LC50) of pathogenic microorganisms and their antigens in vaccine development. ⁶¹	Saganuwan SA	32539814	2020
34	Livestock and Poultry Production in Nepal and Current Status of Vaccine Development. ⁶¹	Poudel U...Dhakal S	32575369	2020
35	A temperature-dependent translation defect caused by IRES mutation attenuates foot-and-mouth disease virus: Implications for rational vaccine design. ⁶¹	Yang D...Yu L	32493820	2020
36	Transcriptome sequencing analysis of SH-SY5Y cells infected with EV71 reveals the potential neuropathic mechanisms. ⁶¹	Hu Y...Zhang Y	32220619	2020
37	Differences in microbiome and virome between cattle and horses in the same farm. ⁶¹	Park J...Kim EB	32054207	2020
38	Acute enterovirus infections significantly alter host cellular DNA methylation status. ⁶¹	Zhu Z...Cao RY	31927072	2020
39	Muscle destruction caused by coxsackievirus A10 in gerbils: construction of a novel animal model for antiviral evaluation. ⁶¹	Chen C...Yao P	32553610	2020
40	Short-term effects of meteorological factors, air pollution, and sunspot on childhood hand, foot, and mouth disease in Tianjin, China: a new time series regression, 2014-2018. ⁶¹	Ji XY...Liu H	32577970	2020
41	The modification effect of the diurnal temperature range on the exposure-response relationship between temperature and pediatric hand, foot and mouth disease. ⁶¹	Hu Y...Li Z	32208268	2020
42	The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease. ⁶¹	Wen W...Wang J	32556480	2020
43	Inhibition of Enterovirus 71 by Selenium Nanoparticles Loaded with siRNA through Bax Signaling Pathways. ⁶¹	Lin Z...Zhu B	32548434	2020
44	Spatial and temporal distribution of foot and mouth disease outbreaks in Amhara region of Ethiopia in the period 1999 to 2016. ⁶¹	Aman E...Jemberu WT	32517750	2020
45	Development and validation of a simplified serotyping ELISA based on monoclonal antibodies for the diagnosis of foot-and-mouth disease virus serotypes O, A, C and Asia 1. ⁶¹	Grazioli S...Brocchi E	32530134	2020
46	Corrigendum to "Development and evaluation of silver amplification immunochromatography kit for foot-and-mouth disease virus antigen detection" [J. Virol. Methods 275C (2019) 113736]. ⁶¹	Morioka K...Fukai K	32418753	2020
47	Probe-based real-time reverse transcription loop-mediated isothermal amplification (RRT-LAMP) assay for rapid and specific detection of foot-and-mouth disease virus. ⁶¹	Lim DR...Park CK	32524762	2020
48	Foot and mouth disease in a wide range of wild hosts: a potential constraint in disease control efforts worldwide particularly in disease-endemic settings. ⁶¹	Rahman AU...Shabbir MZ	32504589	2020
49	Evidence of Combined Effect of Amino Acid Substitutions within G-H and B-C Loops of VP1 Conferring Serological Heterogeneity in Foot-and-Mouth Disease Virus Serotype A. ⁶¹	Islam MR...Hossain MA	32543041	2020
50	A novel particulate delivery system based on antigen-Zn2+ coordination interactions enhances stability and cellular immune response of inactivated foot and mouth disease virus. ⁶¹	Li S...Zhang S	32539415	2020

Sources

Genes for Mouth Disease

Genes related to Mouth Disease (0 elite genes):

(show top 50) (show all 88)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	G3BP1	G3BP Stress Granule Assembly Factor 1	Protein Coding	19.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins (show sections)
2	G3BP2	G3BP Stress Granule Assembly Factor 2	Protein Coding	18.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins (show sections)
3	IL6	Interleukin 6	Protein Coding	14.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TP53	Tumor Protein P53	Protein Coding	14.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CRP	C-Reactive Protein	Protein Coding	13.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TLR4	Toll Like Receptor 4	Protein Coding	13.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL10	Interleukin 10	Protein Coding	13.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TLR7	Toll Like Receptor 7	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	13.5	DISEASES inferred ¹⁵ GeneCards inferred via : Summaries (show sections)
10	TLR3	Toll Like Receptor 3	Protein Coding	13.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IFNG	Interferon Gamma	Protein Coding	13.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IFNA1	Interferon Alpha 1	Protein Coding	13.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	DDX58	DExD/H-Box Helicase 58	Protein Coding	13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	NOTCH1	Notch Receptor 1	Protein Coding	12.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	VDR	Vitamin D Receptor	Protein Coding	12.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	12.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	IL13	Interleukin 13	Protein Coding	12.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	IL17F	Interleukin 17F	Protein Coding	12.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	IRF3	Interferon Regulatory Factor 3	Protein Coding	12.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	12.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	VTN	Vitronectin	Protein Coding	12.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	12.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	BECN1	Beclin 1	Protein Coding	12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	HMGB1	High Mobility Group Box 1	Protein Coding	11.94	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	CTRL	Chymotrypsin Like	Protein Coding	11.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	JAK2	Janus Kinase 2	Protein Coding	11.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
27	JAK1	Janus Kinase 1	Protein Coding	11.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	MX1	MX Dynamin Like GTPase 1	Protein Coding	11.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
29	ATG5	Autophagy Related 5	Protein Coding	11.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
30	MIR221	MicroRNA 221	RNA Gene	11.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
31	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11.55	DISEASES inferred ¹⁵ ¹⁵
32	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	11.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
33	POLI	DNA Polymerase Iota	Protein Coding	11.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	ITGAV	Integrin Subunit Alpha V	Protein Coding	11.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
35	NOTCH2	Notch Receptor 2	Protein Coding	11.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
36	VIM	Vimentin	Protein Coding	11.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
37	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	11.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
38	FUBP1	Far Upstream Element Binding Protein 1	Protein Coding	11.23	DISEASES inferred ¹⁵ GeneCards inferred via : Summaries (show sections)
39	PTBP1	Polypyrimidine Tract Binding Protein 1	Protein Coding	11.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
40	ATG12	Autophagy Related 12	Protein Coding	11.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
41	MIR21	MicroRNA 21	RNA Gene	11.01	DISEASES inferred ¹⁵ ¹⁵
42	OAS1	2'-5'-Oligoadenylate Synthetase 1	Protein Coding	10.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
43	H2AC18	H2A Clustered Histone 18	Protein Coding	10.84	DISEASES inferred ¹⁵ ¹⁵
44	TNFSF4	TNF Superfamily Member 4	Protein Coding	10.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
45	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	10.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
46	GBA	Glucosylceramidase Beta	Protein Coding	10.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
47	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	10.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
48	S100B	S100 Calcium Binding Protein B	Protein Coding	10.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
49	KHDRBS1	KH RNA Binding Domain Containing, Signal Transduction Associated 1	Protein Coding	10.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
50	AQP4	Aquaporin 4	Protein Coding	10.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Mouth Disease

Sources

Expression for Mouth Disease

Search GEO for disease gene expression data for Mouth Disease.

Sources

Pathways for Mouth Disease

Pathways related to Mouth Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.02	TP53 TLR7 TLR4 TLR3 STAT1 IRF3
2	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.56	TP53 STAT1 IL6 IL13 IL10 IFNG
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.44	TP53 TLR7 TLR4 TLR3 STAT1 IL6
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.36	TP53 STAT1 IRF3 IL6 IL17F IL13
5	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.01	TP53 TLR4 TLR3 STAT1 NOTCH1 IRF3
6	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.99	TP53 TLR4 TLR3 STAT1 IRF3 IL6
7	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.89	STAT1 IL6 IL13 IL10 IFNG IFNA1
8	Pathways in cancer ³⁶	12.88	TP53 STAT1 NOTCH1 IL6 IL13 IFNG
9	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.88	TP53 TLR7 TLR4 TLR3 STAT1 IRF3
10	Herpes simplex virus 1 infection ³⁶	12.83	TP53 TLR3 STAT1 IRF3 IL6 IFNG
11	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.76	TLR7 TLR4 TLR3 STAT1 IRF3 IL6
12	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.64	TLR4 STAT1 IL6 IL10 IFNG
13	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.64	TP53 STAT1 IL6 IL17F IL10 IFNG
14	Cytosolic sensors of pathogen-associated DNA ⁶⁵ Show member pathways Cytosolic DNA-sensing pathway ³⁶ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁵ IkBA variant leads to EDA-ID ⁶⁵ IKBKB deficiency causes SCID ⁶⁵ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁵ IRF3 mediated activation of type 1 IFN ⁶⁵ IRF3-mediated induction of type I IFN ⁶⁵ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁵ Regulation by TREX1 ⁶⁵ Regulation of innate immune responses to cytosolic DNA ⁶⁵ RIP-mediated NFkB activation via ZBP1 ⁶⁵ STAT6-mediated induction of chemokines ⁶⁵ STING mediated induction of host immune responses ⁶⁵ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁵ TRAF6 mediated NF-kB activation ⁶⁵ ZBP1(DAI) mediated induction of type I IFNs ⁶⁵	12.6	TLR3 IRF3 IL6 IFNA1 DDX58
15	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.6	TLR4 STAT1 NOTCH1 IL6 IL17F IL13
16	Interferon gamma signaling ⁶⁵ Show member pathways Interferon Signaling ⁶⁵ Regulation of IFNG signaling ⁶⁵	12.59	STAT1 IRF3 IFNG IFNA1 EIF4G1 DDX58
17	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.56	TP53 TLR7 TLR4 TLR3 STAT1 IRF3
18	NF-kappaB Signaling ⁴	12.52	TLR7 TLR3 STAT1 IRF3 IL10 IFNG
19	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.51	STAT1 IL6 IL13 IL10 IFNG IFNA1
20	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.36	TP53 TLR4 TLR3 STAT1 IRF3 IL6
21	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.35	IL6 IL17F IL13 IFNG
22	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.34	TP53 IL6 IFNG CRP
23	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.33	TLR7 TLR4 TLR3 IRF3 IL6
24	NOD-like receptor signaling pathway ³⁶	12.3	TLR4 STAT1 IRF3 IL6 IFNA1
25	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.28	TLR4 STAT1 IL10 IFNG
26	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.26	TLR4 TLR3 STAT1 IFNG IFNA1
27	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.24	TLR7 TLR4 STAT1 IL6 IFNG
28	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.24	TP53 STAT1 IRF3 IL6 IL13 IL10
29	Tuberculosis ³⁶	12.17	VDR TLR4 STAT1 IL6 IL10 IFNG
30	Colorectal Cancer Metastasis ⁶³	12.08	TP53 TLR7 TLR4 TLR3 STAT1 IL6
31	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.07	TP53 TLR7 TLR4 TLR3 STAT1 IL13
32	Yersinia infection ³⁶	12.06	TLR4 IRF3 IL6 IL10
33	Spinal Cord Injury ¹	12.06	TP53 TLR4 IL6 IFNG
34	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	12.04	NOTCH1 IL6 IL10 IFNG
35	Interleukin-4 and 13 signaling ⁶⁵	12.01	TP53 STAT1 IL6 IL17F IL13 IL10
36	Amoebiasis ³⁶	11.98	TLR4 IL6 IL10 IFNG
37	Interferon Pathway ⁶³	11.92	STAT1 IL6 IFNG IFNA1
38	Glucocorticoid receptor regulatory network ¹	11.87	TP53 STAT1 IL6 IL13 IFNG
39	Pertussis ³⁶	11.84	TLR4 IRF3 IL6 IL10
40	IL-6 signaling pathway ¹ Show member pathways IL6-mediated signaling events ¹	11.83	STAT1 IL6 CRP
41	Phagocytosis of Microbes ⁶³	11.83	TLR7 TLR4 TLR3
42	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.82	TLR7 IL6 IL10 IFNG
43	Innate Lymphoid Cells Differentiation ⁶⁴	11.8	IL13 IL10 IFNG
44	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.76	TLR4 SCARB2 NOTCH1
45	Malaria ³⁶	11.6	TLR4 IL6 IL10 IFNG
46	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.59	TP53 IL6 IFNG
47	Interleukin-10 signaling ⁶⁵	11.57	IL6 IL13 IL10
48	Th2 Differentiation ⁶⁴	11.56	NOTCH1 IL13 IL10 IFNG
49	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.53	VDR IL6 IFNG
50	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.46	TLR7 TLR4 TLR3 STAT1 IL6 IL17F

Sources

GO Terms for Mouth Disease

Cellular components related to Mouth Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endosome membrane	GO:0010008	9.46	TLR7 TLR4 TLR3 SCARB2
2	cytoplasmic stress granule	GO:0010494	9.13	G3BP2 G3BP1 EIF4G1
3	receptor complex	GO:0043235	8.92	VDR TLR7 TLR4 NOTCH1

Biological processes related to Mouth Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	10.21	TLR7 TLR4 TLR3 IRF3 G3BP2 G3BP1
2	negative regulation of transcription by RNA polymerase II	GO:0000122	10.19	VDR TP53 STAT1 NOTCH1 IRF3 IFNG
3	positive regulation of transcription, DNA-templated	GO:0045893	10.16	TP53 STAT1 NOTCH1 IRF3 IL6 IL10
4	immune response	GO:0006955	10.11	TLR7 TLR4 NOTCH1 IL6 IL13 IL10
5	innate immune response	GO:0045087	10.11	TLR7 TLR4 TLR3 IRF3 G3BP2 G3BP1
6	negative regulation of cell proliferation	GO:0008285	10.1	VDR TP53 NOTCH1 IL6 IL10
7	inflammatory response	GO:0006954	10.07	TLR7 TLR4 TLR3 IL6 IL17F IL13
8	viral process	GO:0016032	10.03	TP53 STAT1 SCARB2 IRF3 G3BP2 G3BP1
9	cellular response to lipopolysaccharide	GO:0071222	10.01	VDR TLR4 IRF3 IL6 IL10
10	response to lipopolysaccharide	GO:0032496	10	TLR4 NOTCH1 IRF3 IL13 IL10
11	positive regulation of inflammatory response	GO:0050729	9.94	TLR7 TLR4 TLR3 IFNG
12	cellular response to mechanical stimulus	GO:0071260	9.93	TLR7 TLR4 TLR3 IL13
13	interferon-gamma-mediated signaling pathway	GO:0060333	9.92	TP53 STAT1 IRF3 IFNG
14	cytokine-mediated signaling pathway	GO:0019221	9.91	TP53 STAT1 IL6 IL17F IL13 IL10
15	positive regulation of transcription by RNA polymerase II	GO:0045944	9.9	VDR TP53 TLR4 TLR3 STAT1 NOTCH1
16	Ras protein signal transduction	GO:0007265	9.89	TP53 G3BP2 G3BP1
17	humoral immune response	GO:0006959	9.89	NOTCH1 IL6 IFNG IFNA1
18	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.88	IL6 IL13 IFNG
19	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.88	TLR7 TLR4 TLR3
20	type I interferon signaling pathway	GO:0060337	9.88	STAT1 IRF3 IFNA1
21	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.87	TLR7 TLR4 TLR3
22	positive regulation of smooth muscle cell proliferation	GO:0048661	9.87	STAT1 IL6 IL13
23	toll-like receptor signaling pathway	GO:0002224	9.85	TLR7 TLR4 TLR3
24	positive regulation of cytokine secretion	GO:0050715	9.85	IRF3 IL10 IFNG
25	positive regulation of JAK-STAT cascade	GO:0046427	9.85	NOTCH1 IL6 IL10
26	positive regulation of interleukin-6 secretion	GO:2000778	9.85	TLR4 IL17F IFNG DDX58
27	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.84	TLR4 TLR3 IRF3
28	response to exogenous dsRNA	GO:0043330	9.84	TLR3 IRF3 IFNA1 DDX58
29	positive regulation of interleukin-12 production	GO:0032735	9.83	TLR4 TLR3 IFNG
30	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.82	TLR4 IL6 IL17F
31	necroptotic process	GO:0070266	9.81	TP53 TLR4 TLR3
32	positive regulation of macrophage activation	GO:0043032	9.8	TLR4 IL13 IL10
33	cellular response to exogenous dsRNA	GO:0071360	9.8	TLR3 IRF3 DDX58
34	microglial cell activation	GO:0001774	9.8	TLR7 TLR3 IL13 IFNG
35	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.78	TLR4 STAT1 IFNG
36	positive regulation of interleukin-8 production	GO:0032757	9.78	TLR7 TLR4 TLR3 DDX58
37	I-kappaB phosphorylation	GO:0007252	9.76	TLR7 TLR4 TLR3
38	positive regulation of interferon-beta production	GO:0032728	9.76	TLR4 TLR3 IRF3 DDX58
39	positive regulation of MHC class II biosynthetic process	GO:0045348	9.75	TLR4 IL10 IFNG
40	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.73	TLR7 TLR4 TLR3
41	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.72	TP53 IL6
42	positive regulation of interleukin-6 production	GO:0032755	9.72	TLR7 TLR4 TLR3 IL6 DDX58
43	negative regulation of lipid storage	GO:0010888	9.71	IL6 CRP
44	positive regulation of chemokine production	GO:0032722	9.71	TLR7 TLR4 TLR3 IL6
45	cytoplasmic sequestering of NF-kappaB	GO:0007253	9.7	IL10 G3BP2
46	negative regulation of MyD88-independent toll-like receptor signaling pathway	GO:0034128	9.69	TLR4 TLR3
47	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.69	TP53 NOTCH1
48	detection of virus	GO:0009597	9.68	TLR3 DDX58
49	positive regulation of interferon-alpha biosynthetic process	GO:0045356	9.68	TLR7 TLR3
50	positive regulation of stress granule assembly	GO:0062029	9.66	G3BP2 G3BP1

Molecular functions related to Mouth Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.93	VDR TP53 TLR7 TLR4 TLR3 STAT1
2	identical protein binding	GO:0042802	9.86	TP53 TLR4 TLR3 STAT1 IRF3 EIF4G1
3	transmembrane signaling receptor activity	GO:0004888	9.72	TLR7 TLR4 TLR3 SCARB2 NOTCH1
4	signaling receptor activity	GO:0038023	9.71	VDR TLR4 TLR3 NOTCH1
5	double-stranded RNA binding	GO:0003725	9.54	TLR7 TLR3 DDX58
6	cytokine receptor binding	GO:0005126	9.33	IL17F IL13 IFNA1
7	cytokine activity	GO:0005125	9.1	IL6 IL17F IL13 IL10 IFNG IFNA1

Sources

Sources for Mouth Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Mouth Disease

Aliases & Classifications for Mouth Disease

MalaCards integrated aliases for Mouth Disease:

Classifications:

External Ids:

Summaries for Mouth Disease

Related Diseases for Mouth Disease

Diseases related to Mouth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Mouth Disease:

Symptoms & Phenotypes for Mouth Disease

UMLS symptoms related to Mouth Disease:

GenomeRNAi Phenotypes related to Mouth Disease according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Mouth Disease:

Drugs & Therapeutics for Mouth Disease

Drugs for Mouth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: mouth diseases

Genetic Tests for Mouth Disease

Anatomical Context for Mouth Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Mouth Disease:

MalaCards organs/tissues related to Mouth Disease:

Publications for Mouth Disease

Articles related to Mouth Disease:

Genes for Mouth Disease

Genes related to Mouth Disease (0 elite genes):

Variations for Mouth Disease

Expression for Mouth Disease

Pathways for Mouth Disease

Pathways related to Mouth Disease according to GeneCards Suite gene sharing:

GO Terms for Mouth Disease

Cellular components related to Mouth Disease according to GeneCards Suite gene sharing:

Biological processes related to Mouth Disease according to GeneCards Suite gene sharing:

Molecular functions related to Mouth Disease according to GeneCards Suite gene sharing:

Sources for Mouth Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :