Aliases & Classifications for Movement Disease

MalaCards integrated aliases for Movement Disease:

Name: Movement Disease 12 15
Movement Disorders 55 43 44 73
Abnormality of Movement 29 6
Movement Disorder 15

Classifications:



External Ids:

Disease Ontology 12 DOID:480
MeSH 44 D009069
NCIt 50 C116757
SNOMED-CT 68 60342002
UMLS 73 C0026650

Summaries for Movement Disease

MedlinePlus : 43 Movement disorders are neurologic conditions that cause problems with movement, such as Increased movement that can be voluntary (intentional) or involuntary (unintended) Decreased or slow voluntary movement There are many different movement disorders. Some of the more common types include Ataxia, the loss of muscle coordination Dystonia, in which involuntary contractions of your muscles cause twisting and repetitive movements. The movements can be painful. Huntington's disease, an inherited disease that causes nerve cells in certain parts of the brain to waste away. This includes the nerve cells that help to control voluntary movement. Parkinson's disease, which is disorder that slowly gets worse over time. It causes tremors, slowness of movement, and trouble walking. Tourette syndrome, a condition which causes people to make sudden twitches, movements, or sounds (tics) Tremor and essential tremor, which cause involuntary trembling or shaking movements. The movements may be in one or more parts of your body. Causes of movement disorders include Genetics Infections Medicines Damage to the brain, spinal cord, or peripheral nerves Metabolic disorders Stroke and vascular diseases Toxins Treatment varies by disorder. Medicines can cure some disorders. Others get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms and relieve pain.

MalaCards based summary : Movement Disease, also known as movement disorders, is related to stereotypic movement disorder and periodic limb movement disorder, and has symptoms including seizures, ataxia and tremor. An important gene associated with Movement Disease is GBA (Glucosylceramidase Beta). Affiliated tissues include brain, cortex and spinal cord.

Disease Ontology : 12 A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity.

Related Diseases for Movement Disease

Diseases related to Movement Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 398)
# Related Disease Score Top Affiliating Genes
1 stereotypic movement disorder 12.5
2 periodic limb movement disorder 12.5
3 deep brain stimulation for movement disorders 12.2
4 prrt2-associated paroxysmal movement disorders 12.1
5 extrapyramidal and movement disease 12.0
6 psychogenic movement 11.8
7 ocular motility disease 11.7
8 mental retardation, x-linked 102 11.5
9 essential tremor 11.5
10 dystonia 11.5
11 dystonia 12 11.4
12 conversion disorder 11.4
13 parkinson disease, late-onset 11.2
14 dystonia 11, myoclonic 11.2
15 cervical dystonia 11.2
16 blepharospasm 11.2
17 neurodegeneration with brain iron accumulation 1 11.2
18 dystonia, dopa-responsive, due to sepiapterin reductase deficiency 11.2
19 coffin-lowry syndrome 11.1
20 restless legs syndrome 11.1
21 chorea, benign hereditary 11.1
22 dystonia 3, torsion, x-linked 11.1
23 primary orthostatic tremor 11.1
24 central pontine myelinolysis 11.1
25 sandifer syndrome 11.1
26 tremor 11.1
27 birk-landau-perez syndrome 11.1
28 neurodegeneration, childhood-onset, with brain atrophy 11.1
29 focal dystonia 11.1
30 cerebral palsy 11.0
31 multiple sclerosis 11.0
32 tardive dyskinesia 11.0
33 episodic kinesigenic dyskinesia 1 11.0
34 neurodegeneration with brain iron accumulation 5 11.0
35 dystonia 6, torsion 11.0
36 dystonia 16 11.0
37 dystonia 21 11.0
38 antiphospholipid syndrome 11.0
39 paroxysmal nonkinesigenic dyskinesia 1 10.9
40 neurodegeneration with brain iron accumulation 3 10.9
41 primary familial brain calcification 10.9
42 choreoacanthocytosis 10.9
43 cerebrotendinous xanthomatosis 10.9
44 glutaric acidemia i 10.9
45 kuru 10.9
46 mitochondrial myopathy 10.9
47 dyskinesia, familial, with facial myokymia 10.9
48 cerebellar disease 10.9
49 bobble-head doll syndrome 10.9
50 gnao1 encephalopathy 10.9

Graphical network of the top 20 diseases related to Movement Disease:



Diseases related to Movement Disease

Symptoms & Phenotypes for Movement Disease

UMLS symptoms related to Movement Disease:


seizures, ataxia, tremor, myoclonus, dystonia, back pain, pain, clumsiness, involuntary movements, headache, torticollis, muscle fibrillation, syncope, athetosis, pseudobulbar signs, cogwheel rigidity, myokymia, chronic pain, sciatica, akathisia, vertigo/dizziness, sleeplessness, muscle cramp, symptoms, spasm, spasmodic torticollis, hyperexplexia, asterixis, leg cramps

Drugs & Therapeutics for Movement Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases Completed NCT00076271

Search NIH Clinical Center for Movement Disease

Cochrane evidence based reviews: movement disorders

Genetic Tests for Movement Disease

Genetic tests related to Movement Disease:

# Genetic test Affiliating Genes
1 Abnormality of Movement 29

Anatomical Context for Movement Disease

MalaCards organs/tissues related to Movement Disease:

41
Brain, Cortex, Spinal Cord, Eye, Bone, Subthalamic Nucleus, Testes

Publications for Movement Disease

Articles related to Movement Disease:

(show top 50) (show all 1140)
# Title Authors Year
1
Ultrasound elastography in neuromuscular and movement disorders. ( 30308432 )
2019
2
More than ataxia - Movement disorders in ataxia-telangiectasia. ( 29249681 )
2018
3
Defining spasticity: a new approach considering current movement disorders terminology and botulinum toxin therapy. ( 29423615 )
2018
4
Movement disorders in non-encephalopathic Hashimoto's thyroiditis. ( 29887356 )
2018
5
Reflections on 50 Years of Neuroscience Nursing: Movement Disorders, Neuromuscular Disease, and Multiple Sclerosis. ( 29266080 )
2018
6
Ataxia-telangiectasia: A review of movement disorders, clinical features, and genotype correlations. ( 29436738 )
2018
7
Ataxia-telangiectasia: A review of movement disorders, clinical features and genotype correlations - Addendum. ( 30230625 )
2018
8
Movement disorders in autoimmune encephalitis and paraneoplastic neurological syndromes. ( 30201423 )
2018
9
Proportion and spectrum of movement disorders in adolescent and adult patients of autoimmune encephalitis of non-neoplastic aetiology. ( 30455136 )
2018
10
Single-Event Multilevel Surgery to Correct Movement Disorders in Children with Cerebral Palsy. ( 30376177 )
2018
11
Movement disorders in cerebrotendinous xanthomatosis. ( 30054180 )
2018
12
Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. ( 30508027 )
2018
13
Index Finger Pointing (Likely a Subtle Form of Hand Dystonia): Prevalence Across Movement Disorders. ( 30022969 )
2018
14
Pediatric NMDAR encephalitis: A single center observation study with a closer look at movement disorders. ( 29396169 )
2018
15
Early-onset encephalopathy with paroxysmal movement disorders and epileptic seizures without hemiplegic attacks: About three children with novel ATP1A3 mutations. ( 29861155 )
2018
16
Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy. ( 30012219 )
2018
17
Movement disorders in multiple sclerosis and neuromyelitis optica: A clinical marker of neurological disability. ( 29530725 )
2018
18
Restless Legs Syndrome and Other Movement Disorders of Sleep-Treatment Update. ( 30411165 )
2018
19
Antipsychotic-Related Movement Disorders: Drug-Induced Parkinsonism vs. Tardive Dyskinesia-Key Differences in Pathophysiology and Clinical Management. ( 30027457 )
2018
20
Abstracts of the 2nd Pan American Parkinson's Disease and Movement Disorders Congress. ( 29932468 )
2018
21
Movement disorders associated with Neurocysticercosis. ( 29482924 )
2018
22
Movement disorders associated with neurocysticercosis. ( 29506821 )
2018
23
Evaluation of Various Movement Disorders in Patients of Genetically Proven Spinocerebellar Ataxia: A Study from a Tertiary Care Center in Northern India. ( 29720794 )
2018
24
Movement disorders phenomenology in focal motor seizures. ( 30361137 )
2018
25
The Spectrum of Movement Disorders in Childhood-Onset Lysosomal Storage Diseases. ( 29930972 )
2018
26
Eye movement disorders and neurological symptoms in late-onset inborn errors of metabolism. ( 30485556 )
2018
27
Movement Disorders in Treatable Inborn Errors of Metabolism. ( 30557456 )
2018
28
Inborn Errors of Metabolism with Movement Disorders: Defects in Metal Transport and Neurotransmitter Metabolism. ( 29502915 )
2018
29
PET Imaging in Movement Disorders. ( 30322477 )
2018
30
Abnormal postural behavior in patients with functional movement disorders during exposure to stress. ( 30471572 )
2018
31
Neuroimaging Applications in Functional Movement Disorders. ( 30473194 )
2018
32
Transcranial B-Mode Sonography in Movement Disorders. ( 30473195 )
2018
33
Imaging Transplantation in Movement Disorders. ( 30473196 )
2018
34
Treatment of psychiatric disturbances in common hyperkinetic movement disorders. ( 30501439 )
2018
35
Functional Movement Disorders and Placebo: A Brief Review of the Placebo Effect in Movement Disorders and Ethical Considerations for Placebo Therapy. ( 30515436 )
2018
36
The Wide Spectrum of Functional Movement Disorders. ( 30535193 )
2018
37
Why orthotic devices could be of help in the management of Movement Disorders in the young. ( 30547807 )
2018
38
Acute Psychosis and Movement Disorders as First Presentations of Wilson's Disease. ( 30550014 )
2018
39
Botulinum toxin in movement disorders. ( 29503330 )
2018
40
Deep brain stimulation for movement disorders. ( 29503331 )
2018
41
Newer advances in lesional surgery for movement disorders. ( 29503333 )
2018
42
Deep brain stimulation for movement disorders: Surgical nuances. ( 29503334 )
2018
43
Interventions for eye movement disorders due to acquired brain injury. ( 29505103 )
2018
44
Recessive mutations in >VPS13D cause childhood onset movement disorders. ( 29518281 )
2018
45
Acute hyperkinetic movement disorders in Italian paediatric emergency departments. ( 29519947 )
2018
46
Paraneoplastic movement disorders. ( 29561731 )
2018
47
Telemedicine Use for Movement Disorders: A Global Survey. ( 29565764 )
2018
48
Prevalence of functional (psychogenic) parkinsonism in two Swiss movement disorders clinics and review of the literature. ( 29571869 )
2018
49
Phenotypes, genotypes, and the management of paroxysmal movement disorders. ( 29600549 )
2018
50
New Imaging Markers for Movement Disorders. ( 29616343 )
2018

Variations for Movement Disease

ClinVar genetic disease variations for Movement Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GBA NM_000157.3(GBA): c.1448T> C (p.Leu483Pro) single nucleotide variant risk factor rs421016 GRCh37 Chromosome 1, 155205043: 155205043
2 GBA NM_000157.3(GBA): c.1448T> C (p.Leu483Pro) single nucleotide variant risk factor rs421016 GRCh38 Chromosome 1, 155235252: 155235252
3 ITPR1 NM_001168272.1(ITPR1): c.2432C> T (p.Ser811Phe) single nucleotide variant Uncertain significance GRCh37 Chromosome 3, 4715906: 4715906
4 ITPR1 NM_001168272.1(ITPR1): c.2432C> T (p.Ser811Phe) single nucleotide variant Uncertain significance GRCh38 Chromosome 3, 4674222: 4674222

Copy number variations for Movement Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 262562 X 37500000 47300000 Deletion MAOA Movement disorder
2 262566 X 37500000 47300000 Deletion MAOB Movement disorder

Expression for Movement Disease

Search GEO for disease gene expression data for Movement Disease.

Pathways for Movement Disease

GO Terms for Movement Disease

Sources for Movement Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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