MCID: MCH003
MIFTS: 20

Mu Chain Disease

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Mu Chain Disease

MalaCards integrated aliases for Mu Chain Disease:

Name: Mu Chain Disease 12 15
Mu-Chain Disease 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060128
UMLS 70 C0242310

Summaries for Mu Chain Disease

Disease Ontology : 12 A heavy chain disease that results from an overproduction of mu antibody (IgM).

MalaCards based summary : Mu Chain Disease, also known as mu-chain disease, is related to agammaglobulinemia and heavy chain disease. An important gene associated with Mu Chain Disease is IGHM (Immunoglobulin Heavy Constant Mu), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall.

Related Diseases for Mu Chain Disease

Graphical network of the top 20 diseases related to Mu Chain Disease:



Diseases related to Mu Chain Disease

Symptoms & Phenotypes for Mu Chain Disease

Drugs & Therapeutics for Mu Chain Disease

Search Clinical Trials , NIH Clinical Center for Mu Chain Disease

Genetic Tests for Mu Chain Disease

Anatomical Context for Mu Chain Disease

Publications for Mu Chain Disease

Articles related to Mu Chain Disease:

(show all 23)
# Title Authors PMID Year
1
A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. 61
9401282 1997
2
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. 61
8548286 1995
3
The primary structure of mu-chain-disease protein BOT. Peculiar amino-acid sequence of the N-terminal 42 positions. 61
6425189 1984
4
Biochemical findings in a case of mu-chain disease. 61
7460288 1981
5
The primary structure of the constant part of mu-chain-disease protein BOT. 61
6777162 1980
6
mu-chain disease. Report of two new cases. 61
109059 1979
7
[Heavy chain disease: humoral and cellular findings in six patients with mu chain disease (author's transl)]. 61
112103 1979
8
mu-Chain secretion by peripheral blood lymphocytes in mu-chain disease; functional and ultrastructional characterization of cells associated with mu-chain production. 61
410646 1977
9
[Immunochemical study of serum in the diagnosis of mu-chain disease]. 61
404805 1977
10
Mu-chain disease in a case of chronic lymphocytic leukaemia and malignant histiocytoma. II. Immunochemical studies. 61
179131 1976
11
mu-chain disease in a case of chronic lymphocytic leukaemia and malignant histiocytoma. I. Clinical aspects. 61
179130 1976
12
Physicochemical and immunological properties of a mu chain disease protein. 61
815173 1976
13
A new case of heavy mu-chain disease. 61
170667 1975
14
Immunochemical and biochemical study of a human Fcmu-like fragment (mu-chain disease). 61
824130 1975
15
Mu-chain disease. 61
1111471 1975
16
The inter-chain disulfide bonds of a mu-chain disease protein. 61
4609794 1974
17
MU-chain disease in an African patient. 61
4361394 1974
18
[Partial study of a case of heavy mu chain disease]. 61
4211548 1974
19
[Biochemical study of a case of heavy mu chain disease]. 61
4848134 1974
20
[Mu-chain disease and hypergammaglobulinemia--an unusual immunoglobulin disorder with general lymphadenopathy]. 61
4790232 1973
21
Mu-chain disease. 61
5568152 1971
22
Ultrastructural and immunofluorescence studies of the cells associated with mu-chain disease. 61
5542148 1971
23
A new variant of heavy-chain disease (mu-chain disease). 61
5438427 1970

Variations for Mu Chain Disease

Expression for Mu Chain Disease

Search GEO for disease gene expression data for Mu Chain Disease.

Pathways for Mu Chain Disease

Pathways related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 VPREB1 JCHAIN IGLL1
2
Show member pathways
11.05 VPREB1 JCHAIN IGLL1

GO Terms for Mu Chain Disease

Cellular components related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.62 VPREB1 JCHAIN IGLL1 IGHM
2 blood microparticle GO:0072562 9.26 JCHAIN IGHM
3 immunoglobulin complex, circulating GO:0042571 9.16 IGLL1 IGHM
4 pentameric IgM immunoglobulin complex GO:0071756 8.96 JCHAIN IGHM
5 hexameric IgM immunoglobulin complex GO:0071757 8.62 JCHAIN IGHM

Biological processes related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.48 IGHM IGLL1
2 complement activation, classical pathway GO:0006958 9.46 IGHM IGLL1
3 B cell receptor signaling pathway GO:0050853 9.43 IGHM IGLL1
4 innate immune response GO:0045087 9.43 IGHM IGLL1 JCHAIN
5 phagocytosis, engulfment GO:0006911 9.4 IGHM IGLL1
6 positive regulation of B cell activation GO:0050871 9.37 IGHM IGLL1
7 immune response GO:0006955 9.33 IGLL1 JCHAIN VPREB1
8 phagocytosis, recognition GO:0006910 9.32 IGHM IGLL1
9 antibacterial humoral response GO:0019731 8.96 IGHM JCHAIN
10 leukocyte migration GO:0050900 8.92 VPREB1 JCHAIN IGLL1 IGHM

Molecular functions related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 9.32 JCHAIN IGHM
2 phosphatidylcholine binding GO:0031210 9.26 JCHAIN IGHM
3 peptidoglycan binding GO:0042834 9.16 JCHAIN IGHM
4 antigen binding GO:0003823 9.13 JCHAIN IGLL1 IGHM
5 immunoglobulin receptor binding GO:0034987 8.8 JCHAIN IGLL1 IGHM

Sources for Mu Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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