MCID: MCH003
MIFTS: 20

Mu Chain Disease

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Mu Chain Disease

MalaCards integrated aliases for Mu Chain Disease:

Name: Mu Chain Disease 12 15
Mu-Chain Disease 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060128

Summaries for Mu Chain Disease

Disease Ontology : 12 A heavy chain disease that results from an overproduction of mu antibody (IgM).

MalaCards based summary : Mu Chain Disease, also known as mu-chain disease, is related to agammaglobulinemia and heavy chain disease. An important gene associated with Mu Chain Disease is IGHM (Immunoglobulin Heavy Constant Mu), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall.

Related Diseases for Mu Chain Disease

Diseases in the Mu Chain Disease family:

Alpha Chain Disease Delta Chain Disease

Diseases related to Mu Chain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 agammaglobulinemia 11.5
2 heavy chain disease 9.9
3 histiocytoma 9.9
4 macroglobulinemia 9.7
5 alpha chain disease 9.0 JCHAIN SLC3A2

Graphical network of the top 20 diseases related to Mu Chain Disease:



Diseases related to Mu Chain Disease

Symptoms & Phenotypes for Mu Chain Disease

Drugs & Therapeutics for Mu Chain Disease

Search Clinical Trials , NIH Clinical Center for Mu Chain Disease

Genetic Tests for Mu Chain Disease

Anatomical Context for Mu Chain Disease

Publications for Mu Chain Disease

Articles related to Mu Chain Disease:

(show all 17)
# Title Authors Year
1
A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. ( 9401282 )
1997
2
The primary structure of mu-chain-disease protein BOT. Peculiar amino-acid sequence of the N-terminal 42 positions. ( 6425189 )
1984
3
Biochemical findings in a case of mu-chain disease. ( 7460288 )
1981
4
The primary structure of the constant part of mu-chain-disease protein BOT. ( 6777162 )
1980
5
mu-chain disease. Report of two new cases. ( 109059 )
1979
6
mu-Chain secretion by peripheral blood lymphocytes in mu-chain disease; functional and ultrastructional characterization of cells associated with mu-chain production. ( 410646 )
1977
7
Mu-chain disease in a case of chronic lymphocytic leukaemia and malignant histiocytoma. II. Immunochemical studies. ( 179131 )
1976
8
Physicochemical and immunological properties of a mu chain disease protein. ( 815173 )
1976
9
mu-chain disease in a case of chronic lymphocytic leukaemia and malignant histiocytoma. I. Clinical aspects. ( 179130 )
1976
10
Immunochemical and biochemical study of a human Fcmu-like fragment (mu-chain disease). ( 824130 )
1975
11
Mu-chain disease. ( 1111471 )
1975
12
A new case of heavy mu-chain disease. ( 170667 )
1975
13
MU-chain disease in an African patient. ( 4361394 )
1974
14
The inter-chain disulfide bonds of a mu-chain disease protein. ( 4609794 )
1974
15
Ultrastructural and immunofluorescence studies of the cells associated with mu-chain disease. ( 5542148 )
1971
16
Mu-chain disease. ( 5568152 )
1971
17
A new variant of heavy-chain disease (mu-chain disease). ( 5438427 )
1970

Variations for Mu Chain Disease

Expression for Mu Chain Disease

Search GEO for disease gene expression data for Mu Chain Disease.

Pathways for Mu Chain Disease

Pathways related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 JCHAIN SLC3A2 VPREB1
2
Show member pathways
11.05 JCHAIN SLC3A2 VPREB1

GO Terms for Mu Chain Disease

Cellular components related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 IGHM JCHAIN VPREB1
2 blood microparticle GO:0072562 9.16 IGHM JCHAIN
3 pentameric IgM immunoglobulin complex GO:0071756 8.96 IGHM JCHAIN
4 hexameric IgM immunoglobulin complex GO:0071757 8.62 IGHM JCHAIN

Biological processes related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.16 IGHM JCHAIN
2 antibacterial humoral response GO:0019731 8.96 IGHM JCHAIN
3 leukocyte migration GO:0050900 8.92 IGHM JCHAIN SLC3A2 VPREB1

Molecular functions related to Mu Chain Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen binding GO:0003823 9.32 IGHM JCHAIN
2 single-stranded DNA binding GO:0003697 9.26 IGHM JCHAIN
3 immunoglobulin receptor binding GO:0034987 9.16 IGHM JCHAIN
4 phosphatidylcholine binding GO:0031210 8.96 IGHM JCHAIN
5 peptidoglycan binding GO:0042834 8.62 IGHM JCHAIN

Sources for Mu Chain Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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