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MCID: MCN011
MIFTS: 25

Mucinoses

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Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Mucinoses

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MalaCards integrated aliases for Mucinoses:

Name: Mucinoses 11 43 14 71 75

External Ids:

Disease Ontology 11 DOID:3141
MeSH 43 D017520
SNOMED-CT 68 11528001
UMLS 71 C0162855
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Summaries for Mucinoses

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Disease Ontology: 11 A connective tissue disease characterized by accumulation of glycosaminoglycan located in the dermal tissue.

MalaCards based summary: Mucinoses is related to papular mucinosis and scleredema adultorum. An important gene associated with Mucinoses is CHST11 (Carbohydrate Sulfotransferase 11). The drugs Histamine and Tranilast have been mentioned in the context of this disorder. Affiliated tissues include dermal tissue, skin and thyroid.
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Related Diseases for Mucinoses

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Diseases related to Mucinoses via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 papular mucinosis 11.1
2 scleredema adultorum 10.2
3 hypothyroidism 10.2
4 scleromyxedema 10.2
5 myxedema 10.1
6 connective tissue disease 10.1
7 mycosis fungoides 10.1
8 graves disease 1 10.1
9 fungal infectious disease 10.1
10 hyperthyroidism 10.1
11 woolly hair, autosomal dominant 9.9 KRT74 KRT71
12 hypotrichosis 3 9.9 KRT74 KRT71
13 hypotrichosis 9.9 KRT74 KRT71
14 nonsyndromic congenital nail disorder 9.9 KRT74 KRT71
15 hypotrichosis 6 9.9 KRT74 KRT71
16 hypotrichosis 4 9.9 KRT74 KRT71
17 autoimmune disease 9.9
18 ocular motor apraxia 9.9
19 dermatomyositis 9.9
20 skin disease 9.9
21 follicular mucinosis 9.9
22 hypotrichosis 13 9.9 KRT74 KRT71
23 nail disorder, nonsyndromic congenital, 4 9.9 KRT74 KRT71
24 hypotrichosis 8 9.9 KRT74 KRT71
25 ectodermal dysplasia 4, hair/nail type 9.8 KRT74 KRT71
26 t-cell immunodeficiency with thymic aplasia 9.8 KRT71 FOXI3
27 familial woolly hair syndrome 9.8 KRT74 KRT71
28 hair disease 9.7 KRT74 KRT71
29 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 9.7 KRT74 KRT71 FOXI3
30 monilethrix 9.6 KRT74 KRT71

Graphical network of the top 20 diseases related to Mucinoses:



Diseases related to Mucinoses
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Symptoms & Phenotypes for Mucinoses

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Drugs & Therapeutics for Mucinoses

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Drugs for Mucinoses (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Early Phase 1 51-45-6 774
2
Tranilast Investigational Early Phase 1 53902-12-8 5282230
3 Analgesics Early Phase 1
4 Antirheumatic Agents Early Phase 1
5 Neurotransmitter Agents Early Phase 1
6 Hormones Early Phase 1
7 Anti-Allergic Agents Early Phase 1
8 Calcium, Dietary Early Phase 1
9 Platelet Aggregation Inhibitors Early Phase 1
10
Histamine phosphate Early Phase 1 51-74-1 134614
11 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
12 calcium channel blockers Early Phase 1
13 Histamine H1 Antagonists Early Phase 1
14 Histamine Antagonists Early Phase 1
15 Analgesics, Non-Narcotic Early Phase 1
16 Anti-Inflammatory Agents Early Phase 1
17
Calcium Nutraceutical Early Phase 1 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Study of Tranilast in the Treatment of Mucinoses Unknown status NCT03490708 Early Phase 1 Tranilast

Search NIH Clinical Center for Mucinoses

Cochrane evidence based reviews: mucinoses

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Genetic Tests for Mucinoses

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Anatomical Context for Mucinoses

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Organs/tissues related to Mucinoses:

FMA: Dermal Tissue
MalaCards : Skin, Thyroid, Lung
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Publications for Mucinoses

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Articles related to Mucinoses:

(show top 50) (show all 79)
# Title Authors PMID Year
1
New and emerging conditions of acquired cutaneous mucinoses in adults. 62
35124832 2022
2
Obesity-associated lymphedematous mucinosis and stasis mucinosis. 62
34272015 2021
3
Scleromyxedema. 62
33373143 2020
4
Myofibroblast phagocytic cutaneous mucinosis: phagocytosis of mucinous substances by myofibroblasts in a distinctive cutaneous mucinosis: A case report. 62
32702828 2020
5
A Case Report of a Cutaneous Mucinous Reaction Associated with Erlotinib Therapy Used in the Treatment of Metastatic Tonsillar Sinus Squamous Cell Carcinoma. 62
35756178 2020
6
Classifying primary paediatric cutaneous mucinoses. 62
31468512 2020
7
Primary paediatric cutaneous mucinoses. 62
30977896 2020
8
Clinical, dermoscopic, and histologic aspects of two cases of cutaneous focal mucinosis. 62
31365664 2019
9
Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases. 62
31011315 2019
10
Lichen myxedematosus: a rare group of cutaneous mucinosis. 62
31644623 2019
11
Cutaneous mucinosis of infancy: report of a rare case and review of the literature. 62
30677812 2018
12
Review of Primary Cutaneous Mucinoses in Nonlupus Connective Tissue Diseases. 62
28673091 2018
13
Obesity-Associated Lymphedematous Mucinosis: Two Further Cases and Review of the Literature. 62
29719826 2018
14
Trauma-induced Focal Nodular Mucinoses: A Rare Entity. 62
29441300 2018
15
Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review. 62
28712039 2017
16
Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions. 62
27450934 2017
17
Scleromyxedema without Paraproteinemia: Treatment with Thalidomide and Prednisolone. 62
27990110 2016
18
Atypical scleromyxedema presenting with cutaneous and cardiovascular manifestations. 62
27698568 2016
19
[Monoclonal immunoglobulin (M-Ig) and skin diseases from the group of mucinoses--scleredema adultorum Buschke and scleromyxedema. Description of four cases and an overview of therapies]. 62
26806503 2015
20
Transepidermal elimination of mucin is a very common but not yet reported phenomenon in digital myxoid cysts: a study of 35 cases. 62
26264152 2015
21
[Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology]. 62
26188671 2015
22
Periadnexal mucin as an additional histopathologic feature of chronic eczematous dermatitis. 62
25834351 2015
23
Discrete papular lichen myxedematosus: a rare entity or an under- diagnosed disease? 62
25815101 2014
24
Pretibial mucinosis in a patient without Graves disease. 62
22372171 2011
25
Identification of specific chondroitin sulfate species in cutaneous autoimmune disease. 62
21804080 2011
26
Discrete papular dermal mucinosis with Hashimoto thyroiditis: a case report. 62
21488572 2011
27
Cutaneous focal mucinosis arising from the chin. 62
20856067 2010
28
Dermal mucinosis as a sign of venous insufficiency. 62
19614999 2010
29
Discrete papular lichen myxoedematosus: a rare subtype of cutaneous mucinosis. 62
19486062 2009
30
Cutaneous mucinosis associated with dermatomyositis and nephrogenic fibrosing dermopathy: fibroblast hyaluronan synthesis and the effect of patient serum. 62
17300236 2007
31
[Acral persistent papular mucinosis]. 62
17067531 2006
32
Reticular erythematous mucinosis (REM) with telangiectasias associated with essential thrombocytosis and lung carcinoma. 62
15908303 2005
33
Buschke's scleredema and concomitant diseases: report of five cases and literature review. 62
16146615 2005
34
Focal mucinosis: clinical and histological features of an unusual condition. 62
12803795 2003
35
Diffuse cutaneous mucinoses. 62
12170882 2002
36
[Scleredema adultorum in secondary hyperparathyroidism]. 62
11963192 2002
37
Cutaneous focal mucinosis: a case report. 62
11860567 2002
38
Cutaneous mucinoses complicating interferon beta-1b therapy. 62
11844903 2002
39
Cutaneous mucinoses: microscopic criteria for diagnosis. 62
11391115 2001
40
Cutaneous lupus erythematosus. 62
11308132 2001
41
Lipedematous alopecia: a clinicopathologic, histologic and ultrastructural study. 62
10660132 2000
42
Cutaneous mucinoses and HIV infection. 62
9990377 1998
43
Reticulate postinflammatory hyperpigmentation with band-like mucin deposition. 62
9865868 1998
44
Type I and type III collagens in cutaneous mucinosis. 62
9504668 1998
45
Self-healing infantile familial cutaneous mucinosis. 62
9436845 1997
46
[Cutaneous mucinoses]. 62
8668693 1996
47
[Persistent acral papulous mucinosis]. 62
8763749 1996
48
Self-healing juvenile cutaneous mucinosis. 62
7726590 1995
49
[Mucinoses]. 62
7638361 1995
50
[Quadri-chromic staining in routine cutaneous histopathology (hematoxylin, eosin, saffron and astra blue)]. 62
8729819 1995
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Variations for Mucinoses

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Expression for Mucinoses

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Search GEO for disease gene expression data for Mucinoses.
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Pathways for Mucinoses

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GO Terms for Mucinoses

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Biological processes related to Mucinoses according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT74 KRT71
2 intermediate filament organization GO:0045109 8.92 KRT74 KRT71

Molecular functions related to Mucinoses according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 8.92 KRT74 KRT71
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Sources for Mucinoses

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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