Mucinous Intrahepatic Cholangiocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards integrated aliases for Mucinous Intrahepatic Cholangiocarcinoma:

Name: Mucinous Intrahepatic Cholangiocarcinoma ¹² ¹⁵

Mucin-Producing Intrahepatic Cholangiocarcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7024

NCIt ⁵⁰ C41618

UMLS ⁷³ C1513718

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Summaries for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards based summary : Mucinous Intrahepatic Cholangiocarcinoma, also known as mucin-producing intrahepatic cholangiocarcinoma, is related to intrahepatic cholangiocarcinoma and cholangiocarcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Mucinous Intrahepatic Cholangiocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Affiliated tissues include skin, pancreas and small intestine.

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Related Diseases for Mucinous Intrahepatic Cholangiocarcinoma

Diseases related to Mucinous Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	intrahepatic cholangiocarcinoma	29.9	CDX2 MUC2 MUC5AC
2	cholangiocarcinoma	29.9	CDX2 MUC2 MUC5AC
3	cap polyposis	10.1	MUC2 MUC5AC
4	bile duct mucoepidermoid carcinoma	10.0	MUC2 MUC5AC
5	mucoepidermoid carcinoma	10.0	MUC2 MUC5AC
6	tubular adenocarcinoma	10.0	CDX2 MUC2
7	clear cell adenoma	10.0	MUC2 MUC5AC
8	colloid carcinoma of the pancreas	10.0	MUC2 MUC5AC
9	anus adenocarcinoma	10.0	CDX2 MUC5AC
10	pancreatic mucinous cystadenoma	10.0	MUC2 MUC5AC
11	meconium ileus	10.0	MUC2 MUC5AC
12	ovarian mucinous adenocarcinoma	10.0	CDX2 MUC2
13	mucinous adenocarcinoma	10.0	CDX2 MUC2
14	chronic cholangitis	10.0	CDX2 MUC2
15	bile duct adenocarcinoma	10.0	MUC2 MUC5AC
16	anal canal adenocarcinoma	10.0	CDX2 MUC5AC
17	mucinous ovarian cystadenoma	10.0	CDX2 MUC5AC
18	ampulla of vater adenocarcinoma	10.0	CDX2 MUC2
19	microinvasive gastric cancer	10.0	CDX2 MUC2
20	biliary tract neoplasm	10.0	CDX2 MUC2
21	suppurative cholangitis	10.0	CDX2 MUC2
22	otitis media	9.9	MUC2 MUC5AC
23	solid adenocarcinoma with mucin production	9.9	MUC5AC MUC6
24	tumor of exocrine pancreas	9.9	MUC2 MUC6
25	intestinal benign neoplasm	9.9	CDX2 MUC2
26	small intestine adenocarcinoma	9.9	MUC2 MUC6
27	pancreatic intraductal papillary-mucinous neoplasm	9.9	MUC2 MUC6
28	colorectal adenocarcinoma	9.9	CDX2 MUC2
29	cystadenoma	9.9	MUC2 MUC6
30	mucinous tubular and spindle renal cell carcinoma	9.9	MUC2 MUC6
31	cervical polyp	9.9	CDX2 MUC6
32	intestinal disease	9.9	CDX2 MUC2
33	pancreatic ductal carcinoma	9.9	MUC2 MUC6
34	endocervical adenocarcinoma	9.9	CDX2 MUC6
35	cholecystitis	9.9	MUC2 MUC6
36	polyposis, skin pigmentation, alopecia, and fingernail changes	9.8	CDX2 MUC2 MUC5AC
37	hidradenocarcinoma	9.8	CDX2 MUC2 MUC5AC
38	cystitis cystica	9.8	CDX2 MUC2 MUC5AC
39	gastrointestinal system cancer	9.8	CDX2 MUC2
40	chronic ethmoiditis	9.8	MUC2 MUC5AC MUC6
41	bile duct cystadenocarcinoma	9.8	MUC2 MUC5AC MUC6
42	ethmoid sinusitis	9.8	MUC2 MUC5AC MUC6
43	tn polyagglutination syndrome	9.8	MUC2 MUC5AC MUC6
44	epstein-barr virus-associated gastric carcinoma	9.8	MUC2 MUC5AC MUC6
45	colorectal cancer 1	9.8	MUC2 MUC5AC MUC6
46	gastritis	9.8	CDX2 MUC6
47	duodenum adenocarcinoma	9.7	CDX2 MUC2 MUC6
48	appendix disease	9.7	CDX2 MUC2 MUC6
49	duodenal disease	9.7	CDX2 MUC2 MUC6
50	appendix cancer	9.7	CDX2 MUC2 MUC6

Graphical network of the top 20 diseases related to Mucinous Intrahepatic Cholangiocarcinoma:

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Symptoms & Phenotypes for Mucinous Intrahepatic Cholangiocarcinoma

UMLS symptoms related to Mucinous Intrahepatic Cholangiocarcinoma:

abdominal pain, malaise

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Drugs & Therapeutics for Mucinous Intrahepatic Cholangiocarcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Intrahepatic Cholangiocarcinoma

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Genetic Tests for Mucinous Intrahepatic Cholangiocarcinoma

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Anatomical Context for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards organs/tissues related to Mucinous Intrahepatic Cholangiocarcinoma:

⁴¹

Skin, Pancreas, Small Intestine, Appendix

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Publications for Mucinous Intrahepatic Cholangiocarcinoma

Articles related to Mucinous Intrahepatic Cholangiocarcinoma:

#	Title	Authors	Year
1	Mucinous intrahepatic cholangiocarcinoma: a distinct variant. ( 29698701 )	Chi Z...Lin J	2018

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Genes for Mucinous Intrahepatic Cholangiocarcinoma

Genes related to Mucinous Intrahepatic Cholangiocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	15.07	DISEASES inferred ¹⁵
2	CDX2	Caudal Type Homeobox 2	Protein Coding	15.04	DISEASES inferred ¹⁵
3	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	13.58	DISEASES inferred ¹⁵
4	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	4.91	DISEASES inferred ¹⁵

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Variations for Mucinous Intrahepatic Cholangiocarcinoma

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Expression for Mucinous Intrahepatic Cholangiocarcinoma

Search GEO for disease gene expression data for Mucinous Intrahepatic Cholangiocarcinoma.

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Pathways for Mucinous Intrahepatic Cholangiocarcinoma

Pathways related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.05	CDX2 MUC2 MUC5AC MUC6
2	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.84	MUC2 MUC5AC MUC6
3	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.61	MUC2 MUC5AC
4	O-linked glycosylation ⁶⁶ Show member pathways O-linked glycosylation of mucins ⁶⁶	11.59	MUC2 MUC5AC MUC6
5	Diseases of glycosylation ⁶⁶ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁶	11.3	MUC2 MUC5AC MUC6
6	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁶ Show member pathways Dectin-2 family ⁶⁶ Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁶ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁶ Termination of O-glycan biosynthesis ⁶⁶	10.84	MUC2 MUC5AC MUC6

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GO Terms for Mucinous Intrahepatic Cholangiocarcinoma

Cellular components related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	8.8	MUC2 MUC5AC MUC6

Biological processes related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	maintenance of gastrointestinal epithelium	GO:0030277	9.16	MUC2 MUC6
2	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	MUC2 MUC5AC MUC6
3	O-glycan processing	GO:0016266	8.8	MUC2 MUC5AC MUC6

Molecular functions related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	8.62	MUC5AC MUC6

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Sources for Mucinous Intrahepatic Cholangiocarcinoma

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