Mucinous Intrahepatic Cholangiocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards integrated aliases for Mucinous Intrahepatic Cholangiocarcinoma:

Name: Mucinous Intrahepatic Cholangiocarcinoma ¹² ¹⁵

Mucin-Producing Intrahepatic Cholangiocarcinoma ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7024

NCIt ⁵⁰ C41618

UMLS ⁷³ C1513718

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Summaries for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards based summary : Mucinous Intrahepatic Cholangiocarcinoma, also known as mucin-producing intrahepatic cholangiocarcinoma, is related to anus adenocarcinoma and ovarian mucinous adenocarcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Mucinous Intrahepatic Cholangiocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are HIV Life Cycle and CLEC7A (Dectin-1) signaling.

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Related Diseases for Mucinous Intrahepatic Cholangiocarcinoma

Diseases related to Mucinous Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	anus adenocarcinoma	10.3	CDX2 MUC5AC
2	ovarian mucinous adenocarcinoma	10.3	CDX2 MUC2
3	chronic cholangitis	10.2	CDX2 MUC2
4	mucinous ovarian cystadenoma	10.2	CDX2 MUC5AC
5	anal canal adenocarcinoma	10.2	CDX2 MUC5AC
6	appendix cancer	10.2	CDX2 MUC2
7	ampulla of vater adenocarcinoma	10.2	CDX2 MUC2
8	cap polyposis	10.2	MUC2 MUC5AC
9	microinvasive gastric cancer	10.2	CDX2 MUC2
10	bile duct mucoepidermoid carcinoma	10.2	MUC2 MUC5AC
11	clear cell adenoma	10.2	MUC2 MUC5AC
12	biliary tract neoplasm	10.2	CDX2 MUC2
13	tubular adenocarcinoma	10.1	CDX2 MUC2
14	mucinous adenocarcinoma	10.1	CDX2 MUC2
15	secretory meningioma	10.1	CDX2 MUC2
16	colloid carcinoma of the pancreas	10.1	MUC2 MUC5AC
17	gastrointestinal system benign neoplasm	10.1	CDX2 MUC2
18	meconium ileus	10.1	MUC2 MUC5AC
19	suppurative cholangitis	10.1	CDX2 MUC2
20	pancreatic mucinous cystadenoma	10.1	MUC2 MUC5AC
21	pancreatic intraductal papillary-mucinous neoplasm	10.1	MUC2 MUC6
22	tumor of exocrine pancreas	10.1	MUC2 MUC6
23	endocervical adenocarcinoma	10.1	CDX2 MUC6
24	intestinal benign neoplasm	10.1	CDX2 MUC2
25	tn polyagglutination syndrome	10.1	MUC2 MUC6
26	mucinous tubular and spindle renal cell carcinoma	10.0	MUC2 MUC6
27	colorectal adenocarcinoma	10.0	CDX2 MUC2
28	bile duct carcinoma	10.0	CDX2 MUC2
29	cystadenoma	9.9	MUC2 MUC6
30	pancreatic ductal carcinoma	9.8	MUC2 MUC6
31	otitis media	9.8	MUC2 MUC5AC
32	cholecystitis	9.8	MUC2 MUC6
33	gastrointestinal system cancer	9.8	CDX2 MUC2
34	mucoepidermoid carcinoma	9.8	MUC2 MUC5AC
35	polyposis, skin pigmentation, alopecia, and fingernail changes	9.7	CDX2 MUC2 MUC5AC
36	hidradenocarcinoma	9.7	CDX2 MUC2 MUC5AC
37	cystitis cystica	9.7	CDX2 MUC2 MUC5AC
38	ampulla of vater neoplasm	9.6	CDX2 MUC2 MUC6
39	cystic teratoma	9.6	CDX2 MUC2 MUC6
40	duodenum cancer	9.6	CDX2 MUC2 MUC6
41	signet ring cell adenocarcinoma	9.6	CDX2 MUC2 MUC6
42	small intestine cancer	9.6	CDX2 MUC2 MUC6
43	gastritis	9.5	CDX2 MUC6
44	chronic ethmoiditis	9.5	MUC2 MUC5AC MUC6
45	bile duct cystadenocarcinoma	9.5	MUC2 MUC5AC MUC6
46	ethmoid sinusitis	9.5	MUC2 MUC5AC MUC6
47	epstein-barr virus-associated gastric carcinoma	9.5	MUC2 MUC5AC MUC6
48	colorectal cancer 1	9.5	MUC2 MUC5AC MUC6
49	pancreas adenocarcinoma	9.5	MUC2 MUC5AC MUC6
50	cell type cancer	9.3	CDX2 IDH1 MUC2

Graphical network of the top 20 diseases related to Mucinous Intrahepatic Cholangiocarcinoma:

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Symptoms & Phenotypes for Mucinous Intrahepatic Cholangiocarcinoma

UMLS symptoms related to Mucinous Intrahepatic Cholangiocarcinoma:

abdominal pain, malaise

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Drugs & Therapeutics for Mucinous Intrahepatic Cholangiocarcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Intrahepatic Cholangiocarcinoma

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Genetic Tests for Mucinous Intrahepatic Cholangiocarcinoma

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Anatomical Context for Mucinous Intrahepatic Cholangiocarcinoma

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Publications for Mucinous Intrahepatic Cholangiocarcinoma

Articles related to Mucinous Intrahepatic Cholangiocarcinoma:

#	Title	Authors	Year
1	Mucin-producing intrahepatic cholangiocarcinoma with portal vein thrombosis. ( 14696496 )	Nakagohri T....Kobayashi A.	2003

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Genes for Mucinous Intrahepatic Cholangiocarcinoma

Genes related to Mucinous Intrahepatic Cholangiocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDX2	Caudal Type Homeobox 2	Protein Coding	15.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	15.27	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	13.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic	Protein Coding	13.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	5.11	DISEASES inferred ¹⁵

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Variations for Mucinous Intrahepatic Cholangiocarcinoma

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Expression for Mucinous Intrahepatic Cholangiocarcinoma

Search GEO for disease gene expression data for Mucinous Intrahepatic Cholangiocarcinoma.

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Pathways for Mucinous Intrahepatic Cholangiocarcinoma

Pathways related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁶ Show member pathways 2-LTR circle formation ⁶⁶ APOBEC3G mediated resistance to HIV-1 infection ⁶⁶ Assembly Of The HIV Virion ⁶⁶ Binding and entry of HIV virion ⁶⁶ Disease ⁶⁶ Diseases of signal transduction ⁶⁶ Early Phase of HIV Life Cycle ⁶⁶ HIV Infection ⁶⁶ Host Interactions of HIV factors ⁶⁶ Infectious disease ⁶⁶ Integration of provirus ⁶⁶ Late Phase of HIV Life Cycle ⁶⁶	12.99	IDH1 MUC2 MUC5AC MUC6
2	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.84	MUC2 MUC5AC MUC6
3	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.61	MUC2 MUC5AC
4	O-linked glycosylation ⁶⁶ Show member pathways O-linked glycosylation of mucins ⁶⁶	11.59	MUC2 MUC5AC MUC6
5	Diseases of glycosylation ⁶⁶ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁶	11.3	MUC2 MUC5AC MUC6
6	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁶ Show member pathways Dectin-2 family ⁶⁶ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁶ Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁶ Termination of O-glycan biosynthesis ⁶⁶	10.84	MUC2 MUC5AC MUC6

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GO Terms for Mucinous Intrahepatic Cholangiocarcinoma

Cellular components related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	8.8	MUC2 MUC5AC MUC6

Biological processes related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	maintenance of gastrointestinal epithelium	GO:0030277	9.16	MUC2 MUC6
2	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	MUC2 MUC5AC MUC6
3	O-glycan processing	GO:0016266	8.8	MUC2 MUC5AC MUC6

Molecular functions related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	8.62	MUC5AC MUC6

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Sources for Mucinous Intrahepatic Cholangiocarcinoma

¹ BioSystems

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⁷¹ TGDB

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⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia