Mucinous Intrahepatic Cholangiocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards integrated aliases for Mucinous Intrahepatic Cholangiocarcinoma:

Name: Mucinous Intrahepatic Cholangiocarcinoma ¹² ¹⁵

Mucin-Producing Intrahepatic Cholangiocarcinoma ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7024

NCIt ⁵⁰ C41618

UMLS ⁷⁰ C1513718

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Summaries for Mucinous Intrahepatic Cholangiocarcinoma

MalaCards based summary : Mucinous Intrahepatic Cholangiocarcinoma, also known as mucin-producing intrahepatic cholangiocarcinoma, is related to adenocarcinoma and intrahepatic cholangiocarcinoma, and has symptoms including abdominal pain and malaise. An important gene associated with Mucinous Intrahepatic Cholangiocarcinoma is MCCC1 (Methylcrotonyl-CoA Carboxylase Subunit 1), and among its related pathways/superpathways are HIV Life Cycle and CLEC7A (Dectin-1) signaling.

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Related Diseases for Mucinous Intrahepatic Cholangiocarcinoma

Diseases related to Mucinous Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	29.2	SMAD4 MUC1 KRT7 CDX2
2	intrahepatic cholangiocarcinoma	28.5	SMAD4 MUC5AC MUC1 KRT7 IDH1 CDX2
3	cholangiocarcinoma	28.5	SMAD4 MUC5AC MUC1 KRT7 IDH1 CDX2
4	gastric tubular adenocarcinoma	10.2	MUC6 MUC5AC
5	bile reflux	10.2	MUC5AC CDX2
6	small intestine adenocarcinoma	10.2	MUC6 MUC5AC
7	ovary neuroendocrine neoplasm	10.1	KRT7 CDX2
8	anal canal paget's disease	10.1	KRT7 CDX2
9	anal paget's disease	10.1	KRT7 CDX2
10	gastric signet ring cell adenocarcinoma	10.1	KRT7 CDX2
11	ureter adenocarcinoma	10.1	KRT7 CDX2
12	endobronchial lipoma	10.1	MUC5AC KRT7
13	mucinous adenofibroma	10.1	KRT7 CDX2
14	adenosquamous colon carcinoma	10.1	KRT7 CDX2
15	bartholin's gland disease	10.1	KRT7 CDX2
16	bartholin's gland carcinoma	10.1	KRT7 CDX2
17	vulva adenocarcinoma	10.1	KRT7 CDX2
18	vaginal tubulovillous adenoma	10.1	KRT7 CDX2
19	female urethral cancer	10.1	KRT7 CDX2
20	cystitis cystica	10.1	KRT7 CDX2
21	ovarian seromucinous carcinoma	10.1	KRT7 CDX2
22	rectum neuroendocrine neoplasm	10.1	KRT7 CDX2
23	mucinous ovarian cystadenoma	10.1	KRT7 CDX2
24	sigmoid neoplasm	10.1	KRT7 CDX2
25	krukenberg carcinoma	10.1	KRT7 CDX2
26	jejunal cancer	10.1	KRT7 CDX2
27	appendiceal neoplasm	10.1	KRT7 CDX2
28	mucinous bronchioloalveolar adenocarcinoma	10.1	KRT7 CDX2
29	jejunal adenocarcinoma	10.1	KRT7 CDX2
30	gastric diffuse adenocarcinoma	10.1	KRT7 CDX2
31	linitis plastica	10.1	KRT7 CDX2
32	mucinous stomach adenocarcinoma	10.1	KRT7 CDX2
33	esophageal adenosquamous carcinoma	10.1	KRT7 CDX2
34	vaginal adenoma	10.1	KRT7 CDX2
35	vaginal benign neoplasm	10.1	KRT7 CDX2
36	thymus clear cell carcinoma	10.1	KRT7 CDX2
37	bladder clear cell adenocarcinoma	10.1	KRT7 CDX2
38	clear cell basal cell carcinoma	10.1	KRT7 CDX2
39	nasal cavity olfactory neuroblastoma	10.1	KRT7 CDX2
40	cervical mucinous adenocarcinoma	10.1	MUC6 KRT7
41	peritoneal serous adenocarcinoma	10.1	KRT7 CDX2
42	breast neuroendocrine neoplasm	10.1	KRT7 CDX2
43	epididymis adenocarcinoma	10.1	KRT7 CDX2
44	epididymis cancer	10.1	KRT7 CDX2
45	meckel diverticulum	10.1	KRT7 CDX2
46	jejunal neoplasm	10.1	MUC6 KRT7
47	bladder adenocarcinoma	10.1	KRT7 CDX2
48	nasal cavity adenocarcinoma	10.0	KRT7 CDX2
49	chronic cystitis	10.0	KRT7 CDX2
50	bartholin's gland adenocarcinoma	10.0	KRT7 CDX2

Graphical network of the top 20 diseases related to Mucinous Intrahepatic Cholangiocarcinoma:

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Symptoms & Phenotypes for Mucinous Intrahepatic Cholangiocarcinoma

UMLS symptoms related to Mucinous Intrahepatic Cholangiocarcinoma:

abdominal pain; malaise

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Drugs & Therapeutics for Mucinous Intrahepatic Cholangiocarcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Intrahepatic Cholangiocarcinoma

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Genetic Tests for Mucinous Intrahepatic Cholangiocarcinoma

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Anatomical Context for Mucinous Intrahepatic Cholangiocarcinoma

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Publications for Mucinous Intrahepatic Cholangiocarcinoma

Articles related to Mucinous Intrahepatic Cholangiocarcinoma:

(show all 11)

#	Title	Authors	PMID	Year
1	Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocarcinoma. ⁶¹	Shen Z...Cai X	33008300	2020
2	Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review. ⁶¹	Laohawetwanit T...Klaikaew N	32638458	2020
3	Mucinous intrahepatic cholangiocarcinoma: a distinct variant. ⁶¹	Chi Z...Lin J	29698701	2018
4	CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma. ⁶¹	Cai X...Lu L	29510695	2018
5	Biliary intraductal papillary mucinous neoplasia: three case reports. ⁶¹	Yaman B...Kilic M	19347361	2009
6	Intraductal growth-type mucin-producing peripheral cholangiocarcinoma associated with biliary papillomatosis. ⁶¹	Gulluoglu MG...Ariogul O	17240305	2007
7	Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. ⁶¹	Ishikawa A...Nakanuma Y	15048136	2004
8	Mucin-producing intrahepatic cholangiocarcinoma with portal vein thrombosis. ⁶¹	Nakagohri T...Kobayashi A	14696496	2003
9	Intraductal papillary neoplasia of the liver associated with hepatolithiasis. ⁶¹	Chen TC...Nimura Y	11584359	2001
10	Treatment strategy for mucin-producing intrahepatic cholangiocarcinoma: value of percutaneous transhepatic biliary drainage and cholangioscopy. ⁶¹	Sakamoto E...Nimura Y	10512944	1999
11	Intermittent jaundice by tumor emboli from intrahepatic cholangiocarcinoma. ⁶¹	Capizzi PJ...Nagorney DM	1330801	1992

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Genes for Mucinous Intrahepatic Cholangiocarcinoma

Genes related to Mucinous Intrahepatic Cholangiocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MCCC1	Methylcrotonyl-CoA Carboxylase Subunit 1	Protein Coding	6.94	DISEASES inferred ¹⁵
2	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	5.68	DISEASES inferred ¹⁵
3	CDX2	Caudal Type Homeobox 2	Protein Coding	5.63	DISEASES inferred ¹⁵
4	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	4.49	DISEASES inferred ¹⁵
5	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	3.58	DISEASES inferred ¹⁵
6	KRT7	Keratin 7	Protein Coding	3.54	DISEASES inferred ¹⁵
7	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.48	DISEASES inferred ¹⁵
8	SMAD4	SMAD Family Member 4	Protein Coding	3.45	DISEASES inferred ¹⁵

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Variations for Mucinous Intrahepatic Cholangiocarcinoma

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Expression for Mucinous Intrahepatic Cholangiocarcinoma

Search GEO for disease gene expression data for Mucinous Intrahepatic Cholangiocarcinoma.

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Pathways for Mucinous Intrahepatic Cholangiocarcinoma

Pathways related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁵ Show member pathways 2-LTR circle formation ⁶⁵ APOBEC3G mediated resistance to HIV-1 infection ⁶⁵ Assembly Of The HIV Virion ⁶⁵ Binding and entry of HIV virion ⁶⁵ Disease ⁶⁵ Diseases of signal transduction ⁶⁵ Early Phase of HIV Life Cycle ⁶⁵ HIV Infection ⁶⁵ Host Interactions of HIV factors ⁶⁵ Infectious disease ⁶⁵ Integration of provirus ⁶⁵ Late Phase of HIV Life Cycle ⁶⁵	13	SMAD4 MUC6 MUC5AC MUC1 MCCC1 IDH1
2	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	11.91	MUC6 MUC5AC MUC1
3	O-linked glycosylation ⁶⁵ Show member pathways O-linked glycosylation of mucins ⁶⁵	11.7	MUC6 MUC5AC MUC1
4	Diseases of glycosylation ⁶⁵ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁵	11.3	MUC6 MUC5AC MUC1
5	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁵ Show member pathways Dectin-2 family ⁶⁵ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁵ Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁵ Termination of O-glycan biosynthesis ⁶⁵	10.84	MUC6 MUC5AC MUC1

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GO Terms for Mucinous Intrahepatic Cholangiocarcinoma

Cellular components related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	8.8	MUC6 MUC5AC MUC1

Biological processes related to Mucinous Intrahepatic Cholangiocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	somatic stem cell population maintenance	GO:0035019	9.26	SMAD4 CDX2
2	female gonad development	GO:0008585	9.16	SMAD4 IDH1
3	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	MUC6 MUC5AC MUC1
4	O-glycan processing	GO:0016266	8.8	MUC6 MUC5AC MUC1

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Sources for Mucinous Intrahepatic Cholangiocarcinoma

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⁵⁷ OMIM® (Updated 05-Apr-2021)

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