MCID: MCN023
MIFTS: 28

Mucinous Lung Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Mucinous Lung Adenocarcinoma

MalaCards integrated aliases for Mucinous Lung Adenocarcinoma:

Name: Mucinous Lung Adenocarcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080303

Summaries for Mucinous Lung Adenocarcinoma

Disease Ontology : 12 A lung adenocarcinoma with tumor cells floating in pools of mucin that distend alveolar spaces.

MalaCards based summary : Mucinous Lung Adenocarcinoma is related to appendix adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Mucinous Lung Adenocarcinoma is NRG1 (Neuregulin 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. Affiliated tissues include lung, prostate and testis, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Mucinous Lung Adenocarcinoma

Diseases related to Mucinous Lung Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.7 KRAS HRAS
2 mucinous adenocarcinoma 30.6 NRG1 NKX2-1 KRAS
3 bronchiolo-alveolar adenocarcinoma 29.8 NKX2-1 KRAS HRAS
4 adenocarcinoma 29.0 ROS1 NKX2-1 NAPSA KRAS HRAS ERBB3
5 lung cancer susceptibility 3 29.0 ROS1 NKX2-1 NAPSA KRAS HRAS ERBB3
6 struma ovarii 10.1 NKX2-1 KRAS
7 hepatic flexure cancer 10.1 KRAS HRAS
8 trachea carcinoma in situ 10.1 KRAS HRAS
9 signet ring basal cell carcinoma 10.1 KRAS HRAS
10 cobblestone retinal degeneration 10.1 KRAS HRAS
11 immature teratoma of ovary 10.1 KRAS HRAS
12 pancreatic signet ring cell adenocarcinoma 10.1 KRAS HRAS
13 signet ring cell adenocarcinoma 10.1 KRAS HRAS
14 descending colon cancer 10.1 KRAS HRAS
15 ampulla of vater benign neoplasm 10.1 KRAS HRAS
16 transverse colon cancer 10.1 KRAS HRAS
17 periampullary adenoma 10.1 KRAS HRAS
18 bone giant cell sarcoma 10.1 KRAS HRAS
19 acneiform dermatitis 10.1 KRAS HRAS
20 appendiceal neoplasm 10.1 KRAS HRAS
21 gallbladder benign neoplasm 10.1 KRAS HRAS
22 adenosquamous lung carcinoma 10.1 KRAS HRAS
23 wolffian duct adenocarcinoma 10.1 KRAS HRAS
24 benign struma ovarii 10.1 NKX2-1 HRAS
25 noonan syndrome-like disorder with loose anagen hair 1 10.1 KRAS HRAS
26 noonan syndrome-like disorder with loose anagen hair 10.1 KRAS HRAS
27 myh-associated polyposis 10.1 KRAS HRAS
28 ascending colon cancer 10.1 KRAS HRAS
29 biliary tract benign neoplasm 10.1 KRAS HRAS
30 ovarian mucinous neoplasm 10.1 KRAS HRAS
31 malignant exocrine pancreas neoplasm 10.1 KRAS HRAS
32 pancreatic acinar cell adenocarcinoma 10.1 KRAS HRAS
33 mixed cell adenoma 10.1 NRG1 ERBB3
34 appendix disease 10.1 KRAS HRAS
35 bile duct cysts 10.1 KRAS HRAS
36 small intestine adenocarcinoma 10.1 KRAS HRAS
37 ethmoid sinus adenocarcinoma 10.1 KRAS HRAS
38 appendix cancer 10.1 KRAS HRAS
39 duodenum adenocarcinoma 10.1 KRAS HRAS
40 core binding factor acute myeloid leukemia 10.1 KRAS HRAS
41 oculoectodermal syndrome 10.0 KRAS HRAS
42 large intestine adenocarcinoma 10.0 KRAS HRAS
43 nasal cavity adenocarcinoma 10.0 KRAS HRAS
44 eccrine papillary adenoma 10.0 KRAS HRAS
45 cystic teratoma 10.0 NKX2-1 KRAS
46 myasthenic syndrome, congenital, 14 10.0 KRAS HRAS
47 rectosigmoid cancer 10.0 KRAS HRAS
48 female reproductive endometrioid cancer 10.0 KRAS HRAS
49 pulmonary blastoma 10.0 NKX2-1 KRAS
50 anus cancer 10.0 KRAS HRAS

Graphical network of the top 20 diseases related to Mucinous Lung Adenocarcinoma:



Diseases related to Mucinous Lung Adenocarcinoma

Symptoms & Phenotypes for Mucinous Lung Adenocarcinoma

GenomeRNAi Phenotypes related to Mucinous Lung Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.64 HRAS KRAS
2 Decreased viability GR00055-A-2 9.64 HRAS KRAS
3 Decreased viability GR00055-A-3 9.64 KRAS
4 Decreased viability GR00106-A-0 9.64 ERBB3 KRAS
5 Decreased viability GR00221-A-1 9.64 HRAS KRAS ROS1
6 Decreased viability GR00221-A-2 9.64 ERBB3 HRAS KRAS ROS1
7 Decreased viability GR00221-A-3 9.64 HRAS
8 Decreased viability GR00221-A-4 9.64 ERBB3
9 Decreased viability GR00249-S 9.64 ROS1
10 Decreased viability GR00301-A 9.64 ERBB3 KRAS
11 Decreased viability GR00342-S-1 9.64 ROS1
12 Decreased viability GR00381-A-1 9.64 KRAS

MGI Mouse Phenotypes related to Mucinous Lung Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 ERBB3 HRAS KRAS NKX2-1 VSIG1

Drugs & Therapeutics for Mucinous Lung Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Lung Adenocarcinoma

Genetic Tests for Mucinous Lung Adenocarcinoma

Anatomical Context for Mucinous Lung Adenocarcinoma

MalaCards organs/tissues related to Mucinous Lung Adenocarcinoma:

40
Lung, Prostate, Testis

Publications for Mucinous Lung Adenocarcinoma

Articles related to Mucinous Lung Adenocarcinoma:

(show all 17)
# Title Authors PMID Year
1
Value of CT features for predicting EGFR mutations and ALK positivity in patients with lung adenocarcinoma. 61
33707479 2021
2
Identification of tumors with NRG1 rearrangement, including a novel putative pathogenic UNC5D-NRG1 gene fusion in prostate cancer by data-drilling a de-identified tumor database. 61
33583086 2021
3
Comparison of Surgical Outcomes Between Invasive Mucinous and Non-Mucinous Lung Adenocarcinoma. 61
33242433 2020
4
Mucinous lung adenocarcinoma, particularly referring to EGFR-mutated mucinous adenocarcinoma. 61
31859434 2020
5
EGFR and HER3 signaling blockade in invasive mucinous lung adenocarcinoma harboring an NRG1 fusion. 61
30268483 2018
6
Mucinous Lung Adenocarcinoma Metastasis to Testis in a 29 Year Old-A Case Report. 61
29548865 2018
7
Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI. 61
29421153 2018
8
Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression. 61
29515761 2018
9
Pneumonic-type mucinous lung adenocarcinoma diagnosed by transbronchial cryobiopsy. 61
28261482 2017
10
Pro-tumoural CXCL10/CXCR3-A autocrine loop in invasive mucinous lung adenocarcinoma. 61
28845427 2017
11
NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma. 61
27770508 2016
12
[Video-assisted thoracic surgery diagnosis of mucinous (colloid) lung adenocarcinoma: Case report]. 61
26159365 2015
13
Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. 61
26086099 2015
14
Druggable oncogene fusions in invasive mucinous lung adenocarcinoma. 61
24727320 2014
15
¹⁸F-fluorodeoxyglucose uptake on positron emission tomography in mucinous adenocarcinoma. 61
23988690 2013
16
Insulin-like growth factor-1 receptor inhibition overcomes gefitinib resistance in mucinous lung adenocarcinoma. 61
21598249 2011
17
Resection of mucinous lung adenocarcinoma presenting with intractable bronchorrhea. 61
20357626 2010

Variations for Mucinous Lung Adenocarcinoma

Expression for Mucinous Lung Adenocarcinoma

Search GEO for disease gene expression data for Mucinous Lung Adenocarcinoma.

Pathways for Mucinous Lung Adenocarcinoma

Pathways related to Mucinous Lung Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 NRG1 KRAS HRAS ERBB3 CD74
2
Show member pathways
13.16 ROS1 NRG1 KRAS HRAS ERBB3
3
Show member pathways
13.04 ROS1 NRG1 KRAS HRAS ERBB3
4
Show member pathways
12.98 ROS1 NRG1 KRAS HRAS ERBB3
5
Show member pathways
12.44 NRG1 KRAS HRAS ERBB3
6
Show member pathways
12.41 NRG1 KRAS HRAS ERBB3
7
Show member pathways
12.31 NRG1 KRAS HRAS ERBB3
8
Show member pathways
12.24 KRAS HRAS ERBB3
9
Show member pathways
12.11 NRG1 HRAS ERBB3
10 12.09 KRAS HRAS ERBB3
11
Show member pathways
12.02 ROS1 NRG1 KRAS HRAS ERBB3
12
Show member pathways
12.01 NRG1 KRAS HRAS ERBB3
13
Show member pathways
11.99 KRAS HRAS CD74
14
Show member pathways
11.93 NRG1 KRAS HRAS ERBB3
15 11.87 ROS1 NRG1 ERBB3
16
Show member pathways
11.57 NRG1 KRAS HRAS ERBB3
17 11.42 NRG1 KRAS HRAS ERBB3
18
Show member pathways
11.29 NRG1 KRAS HRAS ERBB3
19 11.28 KRAS HRAS
20 11.16 KRAS HRAS
21 11.12 HRAS ERBB3
22 11.12 ROS1 KRAS HRAS
23 11.1 KRAS HRAS
24 11.1 KRAS HRAS
25
Show member pathways
11.07 KRAS HRAS
26
Show member pathways
11.01 KRAS HRAS
27 10.95 KRAS HRAS
28 10.92 KRAS HRAS
29 10.85 KRAS HRAS
30 10.68 NRG1 KRAS HRAS ERBB3
31 10.62 KRAS HRAS

GO Terms for Mucinous Lung Adenocarcinoma

Biological processes related to Mucinous Lung Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 NRG1 KRAS HRAS ERBB3
2 positive regulation of protein phosphorylation GO:0001934 9.69 KRAS HRAS CD74
3 positive regulation of protein tyrosine kinase activity GO:0061098 9.58 NRG1 ERBB3
4 positive regulation of Ras protein signal transduction GO:0046579 9.58 NRG1 HRAS
5 negative regulation of neuron apoptotic process GO:0043524 9.58 KRAS HRAS ERBB3
6 regulation of cell motility GO:2000145 9.57 NRG1 ERBB3
7 oligodendrocyte differentiation GO:0048709 9.56 NRG1 NKX2-1
8 ERBB2 signaling pathway GO:0038128 9.55 NRG1 ERBB3
9 peripheral nervous system development GO:0007422 9.54 NRG1 ERBB3
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.54 ROS1 NRG1 ERBB3
11 neuron fate commitment GO:0048663 9.52 NRG1 NKX2-1
12 epithelial tube branching involved in lung morphogenesis GO:0060441 9.48 NKX2-1 KRAS
13 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 KRAS HRAS
14 MAPK cascade GO:0000165 9.46 NRG1 KRAS HRAS ERBB3
15 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.43 NRG1 ERBB3
16 positive regulation of kinase activity GO:0033674 9.43 ROS1 ERBB3 CD74
17 response to isolation stress GO:0035900 9.32 KRAS HRAS
18 positive regulation of gene expression GO:0010628 9.1 NRG1 NKX2-1 KRAS HRAS ERBB3 CD74
19 negative regulation of secretion GO:0051048 8.96 NRG1 ERBB3

Molecular functions related to Mucinous Lung Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activator activity GO:0030296 8.96 NRG1 ERBB3
2 ErbB-3 class receptor binding GO:0043125 8.62 NRG1 ERBB3

Sources for Mucinous Lung Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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