MCID: MCN004
MIFTS: 28

Mucinous Tubular and Spindle Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards integrated aliases for Mucinous Tubular and Spindle Renal Cell Carcinoma:

Name: Mucinous Tubular and Spindle Renal Cell Carcinoma 12 15
Mucinous Tubular and Spindle Cell Renal Carcinoma 58

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:4472
NCIt 50 C39807
ICD10 via Orphanet 33 C64
Orphanet 58 ORPHA319322
UMLS 70 C1513719

Summaries for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards based summary : Mucinous Tubular and Spindle Renal Cell Carcinoma, also known as mucinous tubular and spindle cell renal carcinoma, is related to renal cell carcinoma, nonpapillary and pancreatic serous cystic neoplasm. An important gene associated with Mucinous Tubular and Spindle Renal Cell Carcinoma is OSCAR (Osteoclast Associated Ig-Like Receptor), and among its related pathways/superpathways are Keratinization and Diseases of glycosylation. Affiliated tissues include breast, kidney and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mucinous Tubular and Spindle Renal Cell Carcinoma

Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 28.4 TFE3 MUC1 MME KRT8 KRT7 KRT19
2 pancreatic serous cystic neoplasm 10.3 MUC6 KRT8
3 neurenteric cyst 10.3 KRT8 KRT18
4 conventional angiosarcoma 10.2 OSCAR CD34
5 idiopathic corneal edema 10.2 KRT8 KRT19
6 pinguecula 10.2 KRT19 KRT10
7 gastric squamous cell carcinoma 10.2 KRT7 KRT10
8 bladder benign neoplasm 10.2 KRT7 AMACR
9 large cell acanthoma 10.2 KRT7 KRT10
10 epithelial predominant wilms' tumor 10.2 KRT7 AMACR
11 bowen's disease 10.2 KRT7 KRT10
12 adhesive otitis media 10.2 KRT8 KRT18
13 jugular foramen meningioma 10.2 MUC4 CD34
14 urethral diverticulum 10.2 KRT7 AMACR
15 eosinophilic variant of chromophobe renal cell carcinoma 10.2 TFE3 KRT7
16 cryptogenic cirrhosis 10.2 KRT8 KRT18
17 hepatic angiomyolipoma 10.2 TFE3 CD34
18 ovarian mucinous neoplasm 10.2 MUC6 KRT7
19 malignant biphasic mesothelioma 10.2 OSCAR KRT10 FUT4
20 endolymphatic sac tumor 10.2 KRT8 KRT7
21 benign breast adenomyoepithelioma 10.2 KRT8 KRT7
22 histiocytoid hemangioma 10.2 TFE3 CD34
23 synovium neoplasm 10.2 KRT8 KRT7
24 nodular hidradenoma 10.2 MUC1 KRT10
25 lung clear cell carcinoma 10.2 KRT7 KRT18
26 duodenum adenocarcinoma 10.2 MUC6 KRT7
27 prostate stromal sarcoma 10.1 KRT8 CD34
28 bile duct mucinous adenocarcinoma 10.1 MUC4 MUC1
29 bladder adenocarcinoma 10.1 KRT7 AMACR
30 glomangiomatosis 10.1 KRT18 CD34
31 malignant exocrine pancreas neoplasm 10.1 MUC6 MUC1
32 esophageal adenosquamous carcinoma 10.1 KRT7 KRT18
33 congenital granular cell tumor 10.1 FUT4 CD34
34 lung sarcomatoid carcinoma 10.1 MUC4 MUC1
35 apocrine sweat gland neoplasm 10.1 KRT8 KRT7
36 gallbladder leiomyosarcoma 10.1 KRT19 CD34
37 renal pelvis adenocarcinoma 10.1 KRT7 KRT19
38 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT19
39 filamentary keratitis 10.1 MUC4 MUC1
40 anal canal adenocarcinoma 10.1 KRT7 KRT19
41 mammary analogue secretory carcinoma 10.1 MUC4 MUC1
42 pericardium cancer 10.1 KRT7 KRT19
43 cribriform carcinoma 10.1 KRT8 KRT7
44 ovarian mucinous adenocarcinoma 10.1 KRT7 AMACR
45 central nervous system fibrosarcoma 10.1 KRT7 CD34
46 eccrine sweat gland cancer 10.1 KRT7 KRT19
47 ovarian germ cell teratoma 10.1 KRT7 KRT19
48 papillary adenoma 10.1 TFE3 KRT7 AMACR
49 breast leiomyosarcoma 10.1 KRT7 CD34
50 breast hemangioma 10.1 KRT7 CD34

Graphical network of the top 20 diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma:



Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma

Symptoms & Phenotypes for Mucinous Tubular and Spindle Renal Cell Carcinoma

GenomeRNAi Phenotypes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.32 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.32 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.32 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.32 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.32 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.32 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.32 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.32 KRT18

Drugs & Therapeutics for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Tubular and Spindle Renal Cell Carcinoma

Genetic Tests for Mucinous Tubular and Spindle Renal Cell Carcinoma

Anatomical Context for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards organs/tissues related to Mucinous Tubular and Spindle Renal Cell Carcinoma:

40
Breast, Kidney, Lung, Appendix, Liver, Skin, Uterus

Publications for Mucinous Tubular and Spindle Renal Cell Carcinoma

Articles related to Mucinous Tubular and Spindle Renal Cell Carcinoma:

# Title Authors PMID Year
1
"Mucin"-secreting papillary renal cell carcinoma: clinicopathological, immunohistochemical, and molecular genetic analysis of seven cases. 61
27072821 2016
2
Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma. 61
26009022 2015
3
Cytologic aspect of mucinous tubular and spindle-cell renal carcinoma in fine-needle aspirates. 61
16900472 2006
4
[Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma]. 61
17058608 2006

Variations for Mucinous Tubular and Spindle Renal Cell Carcinoma

Expression for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search GEO for disease gene expression data for Mucinous Tubular and Spindle Renal Cell Carcinoma.

Pathways for Mucinous Tubular and Spindle Renal Cell Carcinoma

GO Terms for Mucinous Tubular and Spindle Renal Cell Carcinoma

Cellular components related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 OSCAR MUC4 MUC1 MME KRT8 KRT7
2 cell surface GO:0009986 9.65 OSCAR MME KRT10 FUT4 CD34
3 Golgi lumen GO:0005796 9.54 MUC6 MUC4 MUC1
4 keratin filament GO:0045095 9.5 KRT8 KRT7 KRT18
5 apicolateral plasma membrane GO:0016327 9.46 KRT8 KRT19
6 costamere GO:0043034 9.43 KRT8 KRT19
7 dystrophin-associated glycoprotein complex GO:0016010 9.4 KRT8 KRT19
8 intermediate filament GO:0005882 9.35 KRT8 KRT7 KRT19 KRT18 KRT10
9 cell periphery GO:0071944 9.02 KRT8 KRT19 KRT18 FUT4 CD34

Biological processes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 MUC6 MUC4 MUC1
2 maintenance of gastrointestinal epithelium GO:0030277 9.4 MUC6 MUC4
3 keratinization GO:0031424 9.35 KRT8 KRT7 KRT19 KRT18 KRT10
4 O-glycan processing GO:0016266 9.33 MUC6 MUC4 MUC1
5 hepatocyte apoptotic process GO:0097284 9.32 KRT8 KRT18
6 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19
7 cornification GO:0070268 9.02 KRT8 KRT7 KRT19 KRT18 KRT10

Sources for Mucinous Tubular and Spindle Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....