MCID: MCN004
MIFTS: 27

Mucinous Tubular and Spindle Renal Cell Carcinoma

Categories: Nephrological diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards integrated aliases for Mucinous Tubular and Spindle Renal Cell Carcinoma:

Name: Mucinous Tubular and Spindle Renal Cell Carcinoma 12 15
Mucinous Tubular and Spindle Cell Renal Carcinoma 59

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:4472
NCIt 50 C39807
Orphanet 59 ORPHA319322
ICD10 via Orphanet 34 C64
UMLS 73 C1513719

Summaries for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards based summary : Mucinous Tubular and Spindle Renal Cell Carcinoma, also known as mucinous tubular and spindle cell renal carcinoma, is related to cap polyposis and mucinous intrahepatic cholangiocarcinoma. An important gene associated with Mucinous Tubular and Spindle Renal Cell Carcinoma is KRT10 (Keratin 10), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Keratinization. Affiliated tissues include kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mucinous Tubular and Spindle Renal Cell Carcinoma

Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 cap polyposis 10.9 MUC2 MUC4
2 mucinous intrahepatic cholangiocarcinoma 10.8 MUC2 MUC6
3 neurenteric cyst 10.8 KRT18 KRT8
4 large cell acanthoma 10.8 KRT10 KRT7
5 renal adenoma 10.8 AMACR KRT7
6 endolymphatic sac tumor 10.8 KRT7 KRT8
7 bowen's disease 10.8 KRT10 KRT7
8 hidrocystoma 10.7 KRT7 KRT8
9 endocervical carcinoma 10.7 KRT7 MUC6
10 microcystic adenoma 10.7 MUC1 MUC6
11 apocrine sweat gland neoplasm 10.7 KRT7 KRT8
12 nasal cavity cancer 10.7 KRT7 KRT8
13 epithelioid trophoblastic tumor 10.7 KRT18 KRT7
14 sarcomatoid mesothelioma 10.7 MUC1 MUC4
15 solid adenocarcinoma with mucin production 10.7 KRT7 MUC1
16 atypical polypoid adenomyoma 10.7 MME MUC6
17 brooke-spiegler syndrome 10.7 KRT7 KRT8
18 cryptogenic cirrhosis 10.7 KRT18 KRT8
19 endosalpingiosis 10.6 KRT7 MUC1
20 parachordoma 10.6 KRT7 MUC1
21 middle ear adenoma 10.6 KRT7 MUC1
22 malignant mixed mullerian tumor 10.6 KRT7 MUC1
23 balloon cell malignant melanoma 10.6 KRT7 MME
24 mucinous bronchioloalveolar adenocarcinoma 10.6 KRT7 MUC1
25 pleomorphic liposarcoma 10.6 KRT8 MUC1
26 cervical adenoma malignum 10.6 KRT7 MME
27 apocrine adenocarcinoma 10.6 KRT7 MUC1
28 seminal vesicle tumor 10.6 KRT18 KRT7
29 monophasic synovial sarcoma 10.6 KRT7 MUC1
30 cervical mucinous adenocarcinoma 10.6 KRT7 MME
31 idiopathic corneal edema 10.6 KRT19 KRT8
32 papillary ependymoma 10.6 KRT18 KRT8
33 spiradenoma 10.6 KRT7 MUC1
34 filamentary keratitis 10.6 KRT10 MUC1 MUC4
35 fibrolamellar carcinoma 10.6 KRT7 KRT8
36 ovarian lymphoma 10.6 KRT18 MME
37 mucinous ovarian cystadenoma 10.6 KRT7 MUC1
38 atypical choroid plexus papilloma 10.5 KRT7 KRT8
39 bladder lymphoma 10.5 KRT7 MME
40 hidradenoma 10.5 KRT7 MUC1
41 endocervical adenocarcinoma 10.5 KRT7 MUC6
42 adenofibroma 10.5 MME MUC1
43 well-differentiated liposarcoma 10.5 KRT7 MUC1
44 ovarian mucinous adenocarcinoma 10.5 AMACR KRT7 MUC2
45 intrahepatic bile duct adenoma 10.5 KRT19 KRT7
46 paget disease, extramammary 10.5 KRT7 MUC1
47 anal gland adenocarcinoma 10.5 KRT19 KRT7
48 prostate squamous cell carcinoma 10.5 KRT7 KRT8
49 sertoli-leydig cell tumor 10.5 KRT7 MUC1
50 metanephric adenoma 10.5 AMACR KRT18 KRT7

Graphical network of the top 20 diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma:



Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma

Symptoms & Phenotypes for Mucinous Tubular and Spindle Renal Cell Carcinoma

GenomeRNAi Phenotypes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.4 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

Drugs & Therapeutics for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Tubular and Spindle Renal Cell Carcinoma

Genetic Tests for Mucinous Tubular and Spindle Renal Cell Carcinoma

Anatomical Context for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards organs/tissues related to Mucinous Tubular and Spindle Renal Cell Carcinoma:

41
Kidney

Publications for Mucinous Tubular and Spindle Renal Cell Carcinoma

Variations for Mucinous Tubular and Spindle Renal Cell Carcinoma

Expression for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search GEO for disease gene expression data for Mucinous Tubular and Spindle Renal Cell Carcinoma.

Pathways for Mucinous Tubular and Spindle Renal Cell Carcinoma

GO Terms for Mucinous Tubular and Spindle Renal Cell Carcinoma

Cellular components related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 KRT10 KRT18 KRT19 KRT7 KRT8 MME
2 keratin filament GO:0045095 9.5 KRT18 KRT7 KRT8
3 Golgi lumen GO:0005796 9.46 MUC1 MUC2 MUC4 MUC6
4 apicolateral plasma membrane GO:0016327 9.43 KRT19 KRT8
5 costamere GO:0043034 9.4 KRT19 KRT8
6 dystrophin-associated glycoprotein complex GO:0016010 9.37 KRT19 KRT8
7 intermediate filament GO:0005882 9.35 KRT10 KRT18 KRT19 KRT7 KRT8
8 cell periphery GO:0071944 8.92 FUT4 KRT18 KRT19 KRT8

Biological processes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.73 KRT18 KRT19 KRT7 KRT8
2 keratinization GO:0031424 9.65 KRT10 KRT18 KRT19 KRT7 KRT8
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.62 MUC1 MUC2 MUC4 MUC6
4 O-glycan processing GO:0016266 9.46 MUC1 MUC2 MUC4 MUC6
5 hepatocyte apoptotic process GO:0097284 9.4 KRT18 KRT8
6 cell differentiation involved in embryonic placenta development GO:0060706 9.37 KRT19 KRT8
7 maintenance of gastrointestinal epithelium GO:0030277 9.13 MUC2 MUC4 MUC6
8 cornification GO:0070268 9.02 KRT10 KRT18 KRT19 KRT7 KRT8

Molecular functions related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 KRT10 KRT18 KRT7 KRT8

Sources for Mucinous Tubular and Spindle Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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