MCID: MCN004
MIFTS: 27

Mucinous Tubular and Spindle Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards integrated aliases for Mucinous Tubular and Spindle Renal Cell Carcinoma:

Name: Mucinous Tubular and Spindle Renal Cell Carcinoma 12 15
Mucinous Tubular and Spindle Cell Renal Carcinoma 60

Classifications:

Orphanet: 60  
Rare renal diseases


External Ids:

Disease Ontology 12 DOID:4472
NCIt 51 C39807
ICD10 via Orphanet 35 C64
Orphanet 60 ORPHA319322
UMLS 74 C1513719

Summaries for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards based summary : Mucinous Tubular and Spindle Renal Cell Carcinoma, also known as mucinous tubular and spindle cell renal carcinoma, is related to cystic teratoma and cervical adenosquamous carcinoma. An important gene associated with Mucinous Tubular and Spindle Renal Cell Carcinoma is KRT10 (Keratin 10), and among its related pathways/superpathways are Keratinization and O-linked glycosylation. Affiliated tissues include kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Mucinous Tubular and Spindle Renal Cell Carcinoma

Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 cystic teratoma 10.4 KRT7 MUC6
2 cervical adenosquamous carcinoma 10.4 KRT7 MUC6
3 ovarian mucinous neoplasm 10.4 KRT7 MUC6
4 prostatic acinar adenocarcinoma 10.4 AMACR KRT7
5 mixed ductal-endocrine carcinoma 10.4 MUC1 MUC6
6 atypical choroid plexus papilloma 10.4 KRT7 KRT8
7 basaloid squamous cell carcinoma 10.4 KRT7 KRT8
8 vulvar intraepithelial neoplasia 10.4 KRT10 KRT7
9 neurenteric cyst 10.4 KRT18 KRT8
10 large cell acanthoma 10.4 KRT10 KRT7
11 pulmonary hemosiderosis 10.4 KRT7 MUC1
12 endolymphatic sac tumor 10.4 KRT7 KRT8
13 mucinous cystadenocarcinoma 10.4 KRT7 MUC1
14 renal adenoma 10.4 AMACR KRT7
15 tumor of exocrine pancreas 10.4 MUC1 MUC6
16 pancreatic intraductal papillary-mucinous neoplasm 10.4 MUC1 MUC6
17 duodenum adenocarcinoma 10.4 KRT7 MUC6
18 bowen's disease 10.4 KRT10 KRT7
19 hidradenoma 10.4 KRT7 MUC1
20 endocervical carcinoma 10.4 KRT7 MUC6
21 hidrocystoma 10.3 KRT7 KRT8
22 microcystic adenoma 10.3 MUC1 MUC6
23 papillary adenoma 10.3 AMACR KRT7
24 appendix disease 10.3 KRT7 MUC6
25 adenoid squamous cell carcinoma 10.3 KRT7 KRT8
26 ovarian mucinous adenocarcinoma 10.3 AMACR KRT7
27 apocrine sweat gland neoplasm 10.3 KRT7 KRT8
28 nephrogenic adenoma 10.3 AMACR KRT7
29 epithelioid trophoblastic tumor 10.3 KRT18 KRT7
30 nasal cavity cancer 10.3 KRT7 KRT8
31 cryptogenic cirrhosis 10.3 KRT18 KRT8
32 bile duct adenoma 10.3 KRT7 MUC1
33 meningeal melanocytoma 10.3 MME MUC1
34 sarcomatoid mesothelioma 10.3 MUC1 MUC4
35 adenofibroma 10.3 MME MUC1
36 spindle cell synovial sarcoma 10.3 KRT7 OSCAR
37 endosalpingiosis 10.3 KRT7 MUC1
38 parachordoma 10.3 KRT7 MUC1
39 brooke-spiegler syndrome 10.3 KRT7 KRT8
40 secretory meningioma 10.3 KRT7 MUC1
41 middle ear adenoma 10.3 KRT7 MUC1
42 balloon cell malignant melanoma 10.3 KRT7 MME
43 cervical adenoma malignum 10.3 KRT7 MME
44 gastric squamous cell carcinoma 10.3 KRT10 KRT7
45 prostate squamous cell carcinoma 10.3 KRT7 KRT8
46 seminal vesicle tumor 10.3 KRT18 KRT7
47 monophasic synovial sarcoma 10.3 KRT7 MUC1
48 cervical mucinous adenocarcinoma 10.3 KRT7 MME
49 pleomorphic liposarcoma 10.3 KRT8 MUC1
50 pericardium cancer 10.3 KRT19 KRT7

Graphical network of the top 20 diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma:



Diseases related to Mucinous Tubular and Spindle Renal Cell Carcinoma

Symptoms & Phenotypes for Mucinous Tubular and Spindle Renal Cell Carcinoma

GenomeRNAi Phenotypes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.4 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

Drugs & Therapeutics for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Mucinous Tubular and Spindle Renal Cell Carcinoma

Genetic Tests for Mucinous Tubular and Spindle Renal Cell Carcinoma

Anatomical Context for Mucinous Tubular and Spindle Renal Cell Carcinoma

MalaCards organs/tissues related to Mucinous Tubular and Spindle Renal Cell Carcinoma:

42
Kidney

Publications for Mucinous Tubular and Spindle Renal Cell Carcinoma

Variations for Mucinous Tubular and Spindle Renal Cell Carcinoma

Expression for Mucinous Tubular and Spindle Renal Cell Carcinoma

Search GEO for disease gene expression data for Mucinous Tubular and Spindle Renal Cell Carcinoma.

Pathways for Mucinous Tubular and Spindle Renal Cell Carcinoma

Pathways related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 KRT10 KRT18 KRT19 KRT7 KRT8
2
Show member pathways
11.76 MUC1 MUC4 MUC6
3
Show member pathways
11.6 MUC1 MUC4 MUC6
4 11.59 KRT10 KRT18 KRT19 KRT7 KRT8 MUC1
5
Show member pathways
11.29 KRT18 KRT19 KRT7 KRT8

GO Terms for Mucinous Tubular and Spindle Renal Cell Carcinoma

Cellular components related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 KRT10 KRT18 KRT19 KRT7 KRT8 MME
2 Golgi lumen GO:0005796 9.5 MUC1 MUC4 MUC6
3 apicolateral plasma membrane GO:0016327 9.43 KRT19 KRT8
4 keratin filament GO:0045095 9.43 KRT18 KRT7 KRT8
5 costamere GO:0043034 9.4 KRT19 KRT8
6 dystrophin-associated glycoprotein complex GO:0016010 9.37 KRT19 KRT8
7 intermediate filament GO:0005882 9.35 KRT10 KRT18 KRT19 KRT7 KRT8
8 cell periphery GO:0071944 8.92 FUT4 KRT18 KRT19 KRT8

Biological processes related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.73 KRT18 KRT19 KRT7 KRT8
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.5 MUC1 MUC4 MUC6
3 maintenance of gastrointestinal epithelium GO:0030277 9.4 MUC4 MUC6
4 hepatocyte apoptotic process GO:0097284 9.37 KRT18 KRT8
5 keratinization GO:0031424 9.35 KRT10 KRT18 KRT19 KRT7 KRT8
6 O-glycan processing GO:0016266 9.33 MUC1 MUC4 MUC6
7 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT19 KRT8
8 cornification GO:0070268 9.02 KRT10 KRT18 KRT19 KRT7 KRT8

Molecular functions related to Mucinous Tubular and Spindle Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 KRT10 KRT18 KRT7 KRT8

Sources for Mucinous Tubular and Spindle Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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