MCID: MCC002
MIFTS: 47

Mucocutaneous Leishmaniasis

Categories: Infectious diseases

Aliases & Classifications for Mucocutaneous Leishmaniasis

MalaCards integrated aliases for Mucocutaneous Leishmaniasis:

Name: Mucocutaneous Leishmaniasis 12 15 73
American Cutaneous Leishmaniasis 12 73
Mucocutaneous Leishmaniasis, American 12
American Mucocutaneous Leishmaniasis 12
Cutaneous Leishmaniasis, American 12
New World Cutaneous Leishmaniasis 12
Leishmaniasis, Mucocutaneous 44

Classifications:



External Ids:

Disease Ontology 12 DOID:9155
ICD10 33 B55.2
ICD9CM 35 085.5
MeSH 44 D007897

Summaries for Mucocutaneous Leishmaniasis

Disease Ontology : 12 A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

MalaCards based summary : Mucocutaneous Leishmaniasis, also known as american cutaneous leishmaniasis, is related to leishmaniasis and lepromatous leprosy. An important gene associated with Mucocutaneous Leishmaniasis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs Meglumine antimoniate and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and skin, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Mucocutaneous Leishmaniasis

Diseases related to Mucocutaneous Leishmaniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 leishmaniasis 31.8 IL10 TLR9 TNF
2 lepromatous leprosy 30.5 IL10 TNF
3 cutaneous leishmaniasis 30.4 IL10 TLR9 TNF
4 acquired immunodeficiency syndrome 29.7 CCR5 IL10 TNF
5 chagas disease 29.6 CCR5 IL10 TNF
6 wegener granulomatosis 29.6 CCR5 IL10 TNF
7 adult dermatomyositis 10.7 TLR9 TNF
8 central nervous system vasculitis 10.7 TLR9 TNF
9 punctate inner choroidopathy 10.7 IL10 TNF
10 tropical endomyocardial fibrosis 10.7 IL10 TNF
11 microscopic polyangiitis 10.7 IL10 TNF
12 multifocal choroiditis 10.7 IL10 TNF
13 tungiasis 10.7 IL10 TNF
14 endomyocardial fibrosis 10.7 IL10 TNF
15 lichen disease 10.7 TLR9 TNF
16 transient hypogammaglobulinemia 10.7 IL10 TNF
17 middle ear disease 10.7 TLR9 TNF
18 choroiditis 10.7 IL10 TNF
19 idiopathic achalasia 10.6 IL10 TNF
20 trichuriasis 10.6 IL10 TNF
21 clonorchiasis 10.6 IL10 TNF
22 perinatal necrotizing enterocolitis 10.6 TLR9 TNF
23 eye lymphoma 10.6 IL10 TLR9
24 trachoma 10.6 IL10 TNF
25 listeriosis 10.6 IL10 TNF
26 transverse myelitis 10.6 IL10 TNF
27 primary systemic mycosis 10.6 IL10 TNF
28 poliomyelitis 10.6 IL10 TNF
29 intermediate uveitis 10.6 IL10 TNF
30 multidrug-resistant tuberculosis 10.6 IL10 TNF
31 post-transplant lymphoproliferative disease 10.6 IL10 TNF
32 eales disease 10.6 IL10 TNF
33 hemorrhagic fever 10.6 IL10 TNF
34 spotted fever 10.6 IL10 TNF
35 hematopoietic stem cell transplantation 10.6 IL10 TNF
36 panuveitis 10.6 IL10 TNF
37 aseptic meningitis 10.6 IL10 TNF
38 hypersensitivity reaction type iv disease 10.6 TLR9 TNF
39 scrub typhus 10.6 IL10 TNF
40 cytomegalovirus infection 10.6 IL10 TNF
41 genital herpes 10.6 IL10 TLR9
42 plasmodium vivax malaria 10.6 IL10 TNF
43 exanthem 10.6 TLR9 TNF
44 q fever 10.6 IL10 TNF
45 aphthous stomatitis 10.6 IL10 TNF
46 churg-strauss syndrome 10.5 IL10 TNF
47 japanese encephalitis 10.5 TLR3 TNF
48 uterine anomalies 10.5 TLR9 TNF
49 severe hemophilia a 10.5 IL10 TNF
50 epstein-barr virus-associated gastric carcinoma 10.5 IL10 TNF

Graphical network of the top 20 diseases related to Mucocutaneous Leishmaniasis:



Diseases related to Mucocutaneous Leishmaniasis

Symptoms & Phenotypes for Mucocutaneous Leishmaniasis

MGI Mouse Phenotypes related to Mucocutaneous Leishmaniasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 SCYL1 CCR5 TLR3 FLI1 TNF IL10
2 hematopoietic system MP:0005397 9.91 SCYL1 CCR5 TLR3 TLR9 FLI1 TNF
3 immune system MP:0005387 9.87 SCYL1 CCR5 TLR3 TLR9 FLI1 TNF
4 muscle MP:0005369 9.8 SCYL1 CCR5 TLR3 FLI1 TNF IL10
5 neoplasm MP:0002006 9.55 CCR5 TLR3 FLI1 TNF IL10
6 nervous system MP:0003631 9.5 SCYL1 CCR5 TLR3 FLI1 TNF IL10
7 vision/eye MP:0005391 9.02 NID1 SCYL1 CCR5 TNF IL10

Drugs & Therapeutics for Mucocutaneous Leishmaniasis

Drugs for Mucocutaneous Leishmaniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meglumine antimoniate Experimental, Investigational Phase 2, Phase 3 133-51-7
2 Anti-Infective Agents Phase 2, Phase 3,Phase 1
3 Antiparasitic Agents Phase 2, Phase 3,Phase 1
4 Antiprotozoal Agents Phase 2, Phase 3,Phase 1
5
Amphotericin B Approved, Investigational Phase 1, Phase 2,Phase 2 1397-89-3 14956 5280965
6
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
7
Miltefosine Approved, Investigational Phase 2,Phase 1 58066-85-6 3600
8
Coal tar Approved Phase 2 8007-45-2
9
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
10 Anthelmintics Phase 1, Phase 2,Phase 2
11 Antifungal Agents Phase 2,Phase 1
12 Liposomal amphotericin B Phase 1, Phase 2,Phase 2
13 Antimony Sodium Gluconate Phase 1, Phase 2,Phase 2
14 Vasodilator Agents Phase 2
15 Phosphodiesterase Inhibitors Phase 2
16 Platelet Aggregation Inhibitors Phase 2
17 Antioxidants Phase 2
18 Protective Agents Phase 2
19 Radiation-Protective Agents Phase 2
20 Vaccines Phase 1
21
Cortisone acetate Approved, Investigational 1950-04-4, 50-04-4 5745
22
Cortisone 53-06-5 222786
23 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Low Antimonial Dosage in American Mucosal Leishmaniasis Recruiting NCT01301937 Phase 2, Phase 3 Meglumine antimoniate
2 Miltefosine to Treat Mucocutaneous Leishmaniasis Completed NCT01050907 Phase 2 miltefosine
3 Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis Completed NCT01377974 Phase 2 Miltefosine;Standard Treatment Meglumine antimoniate
4 Miltefosine for Mucosal Leishmaniasis Completed NCT00373776 Phase 1, Phase 2 miltefosine 2.5 mg/kg/day for 28 days
5 Miltefosine (Long Course) for Bolivian Mucosal Leishmaniasis Completed NCT00373568 Phase 1, Phase 2 miltefosine: 2.5 mg/kg/day for 42 days
6 Use of Sodium Stibogluconate as a Treatment for Leishmaniasis Completed NCT00657618 Phase 1, Phase 2 Sodium Stibogluconate (SSG)
7 Sodium Stibogluconate Treatment of Leishmaniasis Completed NCT00662012 Phase 2 Sodium Stibogluconate (SSG)
8 Miltefosine to Treat Cutaneous Leishmaniasis in Bolivia Completed NCT00233545 Phase 2 miltefosine;antimony
9 The Association of Miltefosine and Pentoxifylline to Treat Mucosal Leishmaniasis: A Clinical Trial in Brazil Recruiting NCT02530697 Phase 2 Meglumine antimoniate;Miltefosine;Pentoxifylline
10 Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis Completed NCT00111514 Phase 1
11 Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02429518 Miltefosine
12 Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis Recruiting NCT02431429 Miltefosine
13 Cortisone and QTc-Interval Recruiting NCT03082339
14 Diagnosis and Treatment of Leishmanial Infections Recruiting NCT00344188
15 Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis Available NCT00508963 sodium stibogluconate (Pentostam)

Search NIH Clinical Center for Mucocutaneous Leishmaniasis

Cochrane evidence based reviews: leishmaniasis, mucocutaneous

Genetic Tests for Mucocutaneous Leishmaniasis

Anatomical Context for Mucocutaneous Leishmaniasis

MalaCards organs/tissues related to Mucocutaneous Leishmaniasis:

41
T Cells, Testes, Skin, Tongue, Monocytes

Publications for Mucocutaneous Leishmaniasis

Articles related to Mucocutaneous Leishmaniasis:

(show top 50) (show all 152)
# Title Authors Year
1
Rare Tongue Compromising of Mucocutaneous Leishmaniasis by Leishmania Subgenus Viannia. ( 29519666 )
2018
2
Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to<i>Leishmania braziliensis</i>. ( 29405108 )
2018
3
An Atypical Presentation of Disseminated Mucocutaneous Leishmaniasis Caused by <i>Leishmania major</i> In Iran. ( 29963099 )
2018
4
Mucocutaneous Leishmaniasis in Immunocompromised Patients: Report of 4 Cases in Spain. ( 29100620 )
2017
5
Synthetic peptides derived from ribosomal proteins of Leishmania spp. in mucocutaneous leishmaniasis: Diagnostic usefulness. ( 28758598 )
2017
6
Deforming Mucocutaneous Leishmaniasis of the Nose. ( 28538073 )
2017
7
Cost-effectiveness of liposomal amphotericin B in hospitalised patients with mucocutaneous leishmaniasis. ( 29078022 )
2017
8
Unusual presentation of mucocutaneous leishmaniasis in HIV-infected patient. ( 27890957 )
2016
9
Mucocutaneous leishmaniasis. ( 26994882 )
2016
10
Mucocutaneous leishmaniasis with marked facial disfigurement. ( 27643545 )
2016
11
Mucocutaneous leishmaniasis of the nose: a case report. ( 26513953 )
2015
12
Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. ( 25645330 )
2015
13
Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management. ( 26568336 )
2015
14
Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome. ( 26154873 )
2015
15
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 25661291 )
2015
16
Polymerase chain reaction-miniexon: a promising diagnostic method for mucocutaneous leishmaniasis. ( 26452681 )
2015
17
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25830540 )
2015
18
Mucocutaneous leishmaniasis in an 11-year-old girl with ataxia telangectasia - case report. ( 28349799 )
2015
19
Mucocutaneous leishmaniasis caused by Leishmania infantum var Lombardi in an immunocompetent patient, Spain. ( 25559703 )
2015
20
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives. ( 26568335 )
2015
21
Accuracy of mucocutaneous leishmaniasis diagnosis using polymerase chain reaction: systematic literature review and meta-analysis. ( 25946238 )
2015
22
Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports. ( 25442251 )
2015
23
Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area. ( 24923211 )
2014
24
Mucocutaneous leishmaniasis caused by Leishmania donovani infection in an Indian man. ( 25557311 )
2014
25
Ear, nose and throat manifestations of mucocutaneous Leishmaniasis: a literature review. ( 24897964 )
2014
26
Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy. ( 24126182 )
2014
27
Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash. ( 25548691 )
2014
28
A case of mucocutaneous leishmaniasis diagnosed by serology. ( 25041360 )
2014
29
Mucocutaneous leishmaniasis: mucosal manifestations in an endemic country. ( 23867693 )
2013
30
Cutaneous and mucocutaneous leishmaniasis resembling borderline-tuberculoid leprosy: a new clinical presentation? ( 22434112 )
2013
31
Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. ( 24170665 )
2013
32
Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals. ( 23690792 )
2013
33
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. ( 23148292 )
2013
34
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. ( 23637917 )
2013
35
First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. ( 23669431 )
2013
36
Primary lesion of mucocutaneous leishmaniasis simulating external otitis. ( 23108835 )
2012
37
Cutaneous and mucocutaneous leishmaniasis. ( 22632640 )
2012
38
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. ( 22819605 )
2012
39
Mucocutaneous leishmaniasis in a patient treated with anti-TNF-I+ therapy. ( 22427411 )
2012
40
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. ( 21460009 )
2011
41
Diffuse mucocutaneous leishmaniasis. ( 22479746 )
2011
42
Mucocutaneous Leishmaniasis: clinical markers in presumptive diagnosis. ( 21739015 )
2011
43
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. ( 21311023 )
2011
44
Treatment strategies for mucocutaneous leishmaniasis. ( 20606970 )
2010
45
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. ( 19836815 )
2010
46
A chronic mutilating rhinopathy with a delayed diagnosis of mucocutaneous leishmaniasis. ( 20465699 )
2010
47
Cutaneous and mucocutaneous leishmaniasis: emerging therapies and progress in disease management. ( 20163267 )
2010
48
Mucocutaneous leishmaniasis masquerading as Wegener granulomatosis. ( 20375822 )
2010
49
Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. ( 20377337 )
2010
50
Interventions for American cutaneous and mucocutaneous leishmaniasis. ( 19370612 )
2009

Variations for Mucocutaneous Leishmaniasis

Expression for Mucocutaneous Leishmaniasis

Search GEO for disease gene expression data for Mucocutaneous Leishmaniasis.

Pathways for Mucocutaneous Leishmaniasis

Pathways related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CCR5 IL10 TLR3 TLR9 TNF
2
Show member pathways
12.71 IL10 TLR3 TLR9 TNF
3
Show member pathways
12.15 CCR5 IL10 TNF
4
Show member pathways
12.14 TLR3 TLR9 TNF
5
Show member pathways
11.97 TLR3 TLR9 TNF
6
Show member pathways
11.94 CCR5 IL10 TNF
7 11.91 IL10 TLR9 TNF
8
Show member pathways
11.87 IL10 TLR9 TNF
9 11.8 TLR3 TLR9 TNF
10
Show member pathways
11.73 IL10 TLR3 TLR9 TNF
11 11.54 FLI1 IL10 TLR3 TLR9 TNF
12 11.41 IL10 TLR9 TNF
13 11.19 CCR5 IL10 TNF
14 11.12 IL10 TLR9 TNF
15 11.09 IL10 TNF
16 11 IL10 TNF
17 10.68 IL10 TLR9 TNF

GO Terms for Mucocutaneous Leishmaniasis

Cellular components related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endolysosome membrane GO:0036020 8.62 TLR3 TLR9

Biological processes related to Mucocutaneous Leishmaniasis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 TLR3 TLR9 TNF
2 defense response GO:0006952 9.8 CCR5 TLR3 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 TLR3 TLR9 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.79 CCR5 IL10 TNF
5 defense response to bacterium GO:0042742 9.73 IL10 TLR3 TLR9 TNF
6 positive regulation of tumor necrosis factor production GO:0032760 9.67 TLR3 TLR9
7 toll-like receptor signaling pathway GO:0002224 9.67 TLR3 TLR9
8 extrinsic apoptotic signaling pathway GO:0097191 9.67 TLR3 TNF
9 positive regulation of JNK cascade GO:0046330 9.67 TLR3 TLR9 TNF
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.66 IL10 TNF
11 positive regulation of JUN kinase activity GO:0043507 9.66 TLR9 TNF
12 negative regulation of mitotic cell cycle GO:0045930 9.65 IL10 TNF
13 positive regulation of cytokine production GO:0001819 9.65 TLR3 TNF
14 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
15 inflammatory response GO:0006954 9.65 CCR5 IL10 TLR3 TLR9 TNF
16 positive regulation of interferon-beta production GO:0032728 9.64 TLR3 TLR9
17 positive regulation of interleukin-12 production GO:0032735 9.64 TLR3 TLR9
18 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
19 response to molecule of bacterial origin GO:0002237 9.6 IL10 TLR9
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
21 I-kappaB phosphorylation GO:0007252 9.58 TLR3 TLR9
22 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.58 TLR3 TLR9
23 positive regulation of interleukin-6 production GO:0032755 9.58 TLR3 TLR9 TNF
24 positive regulation of chemokine biosynthetic process GO:0045080 9.57 TLR3 TNF
25 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
26 positive regulation of interferon-beta biosynthetic process GO:0045359 9.55 TLR3 TLR9
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.54 TLR3 TLR9 TNF
29 necroptotic signaling pathway GO:0097527 9.52 TLR3 TNF
30 negative regulation of interleukin-8 production GO:0032717 9.51 IL10 TLR9
31 positive regulation of toll-like receptor signaling pathway GO:0034123 9.48 TLR3 TLR9
32 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.46 TLR3 TLR9
33 positive regulation of interleukin-8 production GO:0032757 9.33 TLR3 TLR9 TNF
34 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
35 negative regulation of interleukin-6 production GO:0032715 9.13 IL10 TLR9 TNF
36 positive regulation of chemokine production GO:0032722 8.8 TLR3 TLR9 TNF
37 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 FLI1 IL10 TLR3 TLR9 TNF

Sources for Mucocutaneous Leishmaniasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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