CMCU
MCID: MCC013
MIFTS: 40

Mucocutaneous Ulceration, Chronic (CMCU)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Mucocutaneous Ulceration, Chronic

MalaCards integrated aliases for Mucocutaneous Ulceration, Chronic:

Name: Mucocutaneous Ulceration, Chronic 57 72 29 6
Cmcu 57 72
Skin Ulcer 44

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset in first years of life
one family has been reported (last curated january 2019)
favorable response to tnf inhibitors


HPO:

31
mucocutaneous ulceration, chronic:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 618287
MeSH 44 D012883
SNOMED-CT via HPO 68 26284000 263681008

Summaries for Mucocutaneous Ulceration, Chronic

UniProtKB/Swiss-Prot : 72 Mucocutaneous ulceration, chronic: An autosomal dominant, mucocutaneous disease characterized by chronic mucosal lesions, in absence of recurrent infections.

MalaCards based summary : Mucocutaneous Ulceration, Chronic, also known as cmcu, is related to decubitus ulcer and chronic ulcer of skin. An important gene associated with Mucocutaneous Ulceration, Chronic is RELA (RELA Proto-Oncogene, NF-KB Subunit), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Ethanol and Estazolam have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related phenotypes are oral ulcer and ileitis

More information from OMIM: 618287

Related Diseases for Mucocutaneous Ulceration, Chronic

Diseases related to Mucocutaneous Ulceration, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 decubitus ulcer 29.7 NGF FGF2
2 chronic ulcer of skin 29.5 NGF FGF2
3 anthrax disease 11.0
4 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.8
5 rapidly involuting congenital hemangioma 10.1
6 scleroderma, familial progressive 10.1
7 systemic scleroderma 10.1
8 werner syndrome 10.0
9 osteomyelitis 10.0
10 pyoderma 10.0
11 pyoderma gangrenosum 10.0
12 paroxysmal extreme pain disorder 9.9 PEPD NGF
13 kala-azar 1 9.9
14 respiratory failure 9.9
15 actinomycosis 9.9
16 collagen disease 9.9
17 vasculitis 9.9
18 leishmaniasis 9.9
19 cutaneous leishmaniasis 9.9
20 dry eye syndrome 9.9 NGF FGF2
21 neuroma 9.9 NGF FGF2
22 corneal disease 9.9 NGF FGF2
23 diabetic neuropathy 9.9 NGF FGF2
24 keratitis, hereditary 9.8 NGF FGF2
25 brittle bone disorder 9.8 PEPD FGF2
26 breast cancer 9.7
27 colorectal cancer 9.7
28 hair whorl 9.7
29 hypercholesterolemia, familial, 1 9.7
30 systemic lupus erythematosus 9.7
31 retinoblastoma 9.7
32 neural tube defects 9.7
33 temporal arteritis 9.7
34 incontinentia pigmenti 9.7
35 budd-chiari syndrome 9.7
36 meningioma, familial 9.7
37 buruli ulcer 9.7
38 gastric cancer 9.7
39 beta-thalassemia 9.7
40 melioidosis 9.7
41 small cell carcinoma 9.7
42 diffuse large b-cell lymphoma 9.7
43 chronic venous insufficiency 9.7
44 lymphoma 9.7
45 colitis 9.7
46 myxofibrosarcoma 9.7
47 intracranial meningioma 9.7
48 hypogonadotropic hypogonadism 9.7
49 venous insufficiency 9.7
50 dermatomyositis 9.7

Graphical network of the top 20 diseases related to Mucocutaneous Ulceration, Chronic:



Diseases related to Mucocutaneous Ulceration, Chronic

Symptoms & Phenotypes for Mucocutaneous Ulceration, Chronic

Human phenotypes related to Mucocutaneous Ulceration, Chronic:

31
# Description HPO Frequency HPO Source Accession
1 oral ulcer 31 very rare (1%) HP:0000155
2 ileitis 31 very rare (1%) HP:0032564
3 vaginal mucosal ulceration 31 very rare (1%) HP:0032565

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Abdomen Gastrointestinal:
ileitis
mucosal ulcerations

Genitourinary Internal Genitalia Female:
vaginal mucosal ulcerations

Head And Neck Mouth:
oral mucosal ulcerations

Immunology:
no recurrent infections

Clinical features from OMIM®:

618287 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Mucocutaneous Ulceration, Chronic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 FGF2 NGF PEPD RELA
2 vision/eye MP:0005391 8.92 FGF2 NGF PEPD RELA

Drugs & Therapeutics for Mucocutaneous Ulceration, Chronic

Drugs for Mucocutaneous Ulceration, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Estazolam Approved, Illicit Phase 4 29975-16-4 3261
3 Anesthetics Phase 4
4 Pharmaceutical Solutions Phase 4
5 Neurotransmitter Agents Phase 4
6 Psychotropic Drugs Phase 4
7 Anticonvulsants Phase 4
8 Liver Extracts Phase 4
9 Anti-Anxiety Agents Phase 4
10 GABA Modulators Phase 4
11
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
12
Metronidazole Approved Phase 3 443-48-1 4173
13
Becaplermin Approved, Investigational Phase 3 165101-51-9
14
Macitentan Approved Phase 3 441798-33-0
15 Calcium, Dietary Phase 3
16 Antihypertensive Agents Phase 3
17 Antiparasitic Agents Phase 3
18 Antiprotozoal Agents Phase 3
19 Endothelin Receptor Antagonists Phase 3
20 Anticoagulants Phase 3
21 Angiogenesis Inducing Agents Phase 3
22 Endothelin A Receptor Antagonists Phase 3
23
Calcium Nutraceutical Phase 3 7440-70-2 271
24
Ofloxacin Approved Phase 2 82419-36-1 4583
25
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
26
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 9552079 2713
27
Sodium citrate Approved, Investigational Phase 2 68-04-2
28
Diltiazem Approved, Investigational Phase 2 42399-41-7 39186
29
Petrolatum Approved, Investigational Phase 2 8009-03-8
30
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
31
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
32
Riociguat Approved Phase 2 625115-55-1
33
Treprostinil Approved, Investigational Phase 1, Phase 2 81846-19-7 54786 6918140
34
Coal tar Approved Phase 1, Phase 2 8007-45-2
35
Iron Approved Phase 1, Phase 2 7439-89-6 23925 29936
36
Deferoxamine Approved, Investigational Phase 1, Phase 2 70-51-9 2973
37
Nitric Oxide Approved Phase 2 10102-43-9 145068
38
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
39 Mitogens Phase 2
40 insulin Phase 2
41 Insulin, Globin Zinc Phase 2
42 Somatomedin B Phase 2
43 Cytochrome P-450 Enzyme Inhibitors Phase 2
44 Anti-Infective Agents, Local Phase 2
45 Arginine butyrate Phase 2
46 Chlorhexidine gluconate Phase 2
47 Phosphodiesterase Inhibitors Phase 2
48 Citrate Phase 2
49 Sildenafil Citrate Phase 2 171599-83-0
50 Phosphodiesterase 5 Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Effectiveness Comparison Between the Use of Skin Micro-grafts vs Meshed Split Thickness Skin Grafts in Cutaneous Defects: A Randomized Controlled Clinical Trial Unknown status NCT02813213 Phase 4
2 A Monocentric, Comparative and Randomized Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery Unknown status NCT03823963 Phase 4
3 Effectiveness of Topical Negative Handicraft Device for Versus Traditional Conservative Treatment in Skin Ulcers Management in Lower Limb Completed NCT02512159 Phase 4
4 The First Affiliated Hospital of Guangzhou University of Chinese Medicine Active, not recruiting NCT03997058 Phase 4 Oral estazolam medication
5 A 12-week, Prospective, Open-label, Randomized, Controlled Clinical Trial Comparing Negative Pressure Wound Therapy (NPWT) to Standard Wound Care for the Treatment of Chronic Pressure Wounds of the Pelvic Region Terminated NCT00691821 Phase 4
6 A Comparative Study of the Healing of Chronic Skin Ulcers of Recessive Dystrophic Epidermolysis Bullosa : Standard Dressing Versus Amniotic Membrane. Unknown status NCT02286427 Phase 3
7 Clinical Efficacy of Platelet Gel From Cord Blood for the Treatment of Diabetic Foot Ulcers Completed NCT02389010 Phase 3
8 An Open, Uncontrolled Study Investigating the Safety and Efficacy of GK567 in the Deodorization of Malodorous Infected Cutaneous Fungating Neoplastic Tumours, Over 14 Days of Treatment Completed NCT01541930 Phase 3 GK567
9 Long-term Bosentan Open Label Extension of the AC-052-331 Study in Systemic Sclerosis Patients With Ischemic Digital Ulcers Completed NCT00319696 Phase 3 Bosentan 62.5 mg;Bosentan 125 mg
10 A Randomized, Double-blind, Placebo-controlled, Multi-center Study to Assess the Effect of Bosentan on Healing and Prevention of Ischemic Digital Ulcers in Patients With Systemic Sclerosis Completed NCT00077584 Phase 3 Bosentan 62.5 mg;Bosentan 125 mg;Placebo
11 Study of Non Inferiority of Product Kollagenase ®, Manufactured by Laboratory Cristália When Compared With Iruxol ®, Manufactured by Abbott Laboratory, in the Treatment of Cutaneous Ulcers Suspended NCT00701974 Phase 2, Phase 3
12 A Multicenter Clinical Evaluation of the Efficacy and Safety of REGRANEX Gel in the Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers Terminated NCT00034788 Phase 3 Becaplermin
13 Prospective, Randomized, Placebo-controlled, Double-blind, Multicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Patients With Ischemic Digital Ulcers Associated With Systemic Sclerosis Terminated NCT01474122 Phase 3 Macitentan 3 mg;Macitentan 10 mg;Placebo
14 A Prospective, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial Comparing Two Doses of VF001-DP to Placebo as an Adjunct to Standard Care in Patients With Chronic Venous Leg Ulcers Unknown status NCT02973893 Phase 2
15 Mesenchymal Stromal Cells for Angiogenesis and Neovascularisation in Digital Ulcers of Systemic Sclerosis: the MANUS Trial Unknown status NCT03211793 Phase 1, Phase 2 Mesenchymal stromal cells
16 A Randomised, Double-Blind, Repeat-Dose, Placebo-Controlled Phase IIa Proof of Concept Study to Investigate the Safety and Efficacy of Oral BBR-012 in Combination With Standard Medical Care in Diabetic Patients With Complicated Skin Ulceration on the Foot (Diabetic Foot Ulcer) Unknown status NCT01342497 Phase 2 isoniazide;placebo
17 An Interventional, Multicenter, Single Arm, Phase I/IIa Clinical Trial to Investigate the Efficacy and Safety of Allo-APZ2-DFU on Wound Healing of Diabetic Neuropathic Ulcer (DFU) Completed NCT03267784 Phase 1, Phase 2
18 An Interventional, Single Arm, Multicenter, Phase I/IIa Clinical Trial to Investigate the Efficacy and Safety of Allo-APZ2-CVU on Wound Healing of Chronic Venous Ulcer (CVU) Completed NCT03257098 Phase 1, Phase 2
19 A Study to Investigate the Safety and Efficacy of a Topical Gentamicin-Collagen Sponge Compared to Levofloxacin in Diabetic Patients With a Mild Infection of a Lower Extremity Skin Ulcer Completed NCT00593567 Phase 2 gentamicin-collagen sponge;Levofloxacin
20 Phase II Trial of Arginine Butyrate for Treatment of Refractory Leg Ulcers in Sickle Cell Disease or Beta Thalassemia Completed NCT00004412 Phase 2 Arginine Butyrate
21 An Accessible Low-cost Plant Treatment for Cutaneous Ulcers Completed NCT04453124 Phase 2
22 Effect of Sildenafil on Digital Ulcers in Systemic Sclerosis Completed NCT00624273 Phase 2 Sildenafil therapy
23 Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers. Completed NCT02801305 Phase 2 Diltiazem Gel 2%;Nitroglycerin Ointment 2%;Vaseline
24 Trial to Confirm the Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis Completed NCT03007004 Phase 2 Botulinum toxin type B (2500 units / vial);Physiological saline
25 A Randomized, Parallel Group, Controlled Study to Assess the Efficacy and Safety of NMBM in the Treatment of Subjects With a Post-cellulitis and Venous Leg Ulcer Completed NCT01770509 Phase 1, Phase 2
26 Treatment of Cutaneous Ulcers With a Novel Biological Dressing Completed NCT00207818 Phase 1, Phase 2
27 A Multi-center Randomized, Double Blind, Placebo-controlled, Pilot Study to Assess the Efficacy and Safety of Riociguat in Scleroderma - Associated Digital Ulcers Completed NCT02915835 Phase 2 Riociguat;Placebo
28 Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers Recruiting NCT03654989 Phase 1, Phase 2 Treprostinil iontophoresis
29 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of the Safety and Efficacy of Deferoxamine Intradermal Delivery Patch (DIDP) in Chronic Sickle Cell Leg Ulcers Recruiting NCT04058197 Phase 1, Phase 2 Deferoxamine Product
30 A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Local Tolerability of Crisaborole Ointment, 2%, in Adult Participants With Stasis Dermatitis Without Active Skin Ulceration Recruiting NCT04091087 Phase 2 crisaborole ointment
31 An Interventional, Single Arm, Phase I/IIa Clinical Trial to Investigate the Efficacy and Safety of APZ2 on Wound Healing of Chronic Venous Ulcer (CVU) Terminated NCT02742844 Phase 1, Phase 2
32 A Phase II Trial on the Reduction of Methicillin Resistant Staphylococcus Aureus in MRSA Positive Ulcers Terminated NCT00790608 Phase 2 Nitric Oxide
33 A Phase II, Randomized, Parallel, Double-blind, Placebo-controlled Study to Assess Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With Uninfected Lower Extremity Skin Ulcers Terminated NCT00658957 Phase 2 gentamicin-collagen sponge;placebo collagen sponge
34 Efficacy and Safety of Autologous Bone Marrow Stem Cells Infusion for Treatment of Chronic Leg Ulcer in Sickle Cell Disease Patients Unknown status NCT02619734 Phase 1
35 Umbilical Cord Mesenchymal Stem Cells Between Gel Treatment Difficult Skin Ulcer Healing Efficacy and Safety of Random, Open, Before-and-after Study Completed NCT02685722 Phase 1
36 The Regeneration Effects of Derma-PACE Shockwave in Chronic Diabetic Ulcers Unknown status NCT01219127
37 The Clinical & Economic Evaluation of Bio-ConneKt® Wound Dressing in Treating Chronic Foot Ulcers (Diabetic and/or Venous Ulcers). Unknown status NCT02309684
38 Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting Unknown status NCT01932021
39 Evaluation of Locally-sourced Compression Therapy for Treatment of Chronic Leg Ulcers and Management of Kaposi Sarcoma Leg Lymphedema in Western Kenya Unknown status NCT03404297
40 Regional Grafting of Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers: a Prospective Randomized Controlled Study Unknown status NCT03406988
41 Evaluation of the Clinical Utility, Efficacy and Safety of a Novel Medical Device (Carbothera) in the Treatment of Foot Ulcers Unknown status NCT02239419
42 Evaluation of Vaporous Hyperoxia Therapy (VHT) for Chronic Wounds Completed NCT04244201
43 Using of Irradiated Amnion Dressing for the Treatment of Skin Ulcer Completed NCT03440528
44 Ultrasonic Surgical Wound Debridement vs. Standard Sharp Debridement In the Treatment of Chronic Wounds: A Single Center, Randomized, Parallel, Clinical Outcome Trial Completed NCT01237392
45 A Prospective, Multi-Center, Randomized, Parallel-group Study Comparing AMNIOEXCEL Plus Placental Allograft Membrane to a Marketed Comparator and Standard of Care Procedures in the Management of Diabetic Foot Ulcers Completed NCT03547635
46 A Multi-centre Randomised Controlled Trial to Compare Epidermal Grafting With Split Skin Grafting for Wound Healing Completed NCT02535481
47 The Effect of Support Surfaces in the Incidence of Pressure Injuries in Critically Ill Patients: a Randomized Clinical Trial Completed NCT02844166
48 A National, Observational, Multi-center Registry to Examine the Characteristics of Patients With Systematic Sclerosis Digital Ulcers and Assess Bosentan Treatment. Completed NCT02798055 Bosentan group
49 Efficacy of Inhaled 50% Equimolar Nitrous Oxide/Oxygen Gas Premix (Kalinox®) as Compared to Topically Administered 5% Eutectic Mixture of Lidocaine/Prilocaine (EMLA®) in Chronic Leg Ulcer Debridement Completed NCT02696460
50 Preventing Pressure Ulcers (PU) in Intensive Care Units - The Effectiveness of Dry Washcloths Versus Usual Care: A Cluster-crossover Protocol Completed NCT03445975

Search NIH Clinical Center for Mucocutaneous Ulceration, Chronic

Cochrane evidence based reviews: skin ulcer

Genetic Tests for Mucocutaneous Ulceration, Chronic

Genetic tests related to Mucocutaneous Ulceration, Chronic:

# Genetic test Affiliating Genes
1 Mucocutaneous Ulceration, Chronic 29 RELA

Anatomical Context for Mucocutaneous Ulceration, Chronic

MalaCards organs/tissues related to Mucocutaneous Ulceration, Chronic:

40
Skin, Bone Marrow, Bone, Lung, Eye, Spinal Cord, Liver

Publications for Mucocutaneous Ulceration, Chronic

Articles related to Mucocutaneous Ulceration, Chronic:

(show all 27)
# Title Authors PMID Year
1
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. 6 57
28600438 2017
2
Cellulose fibers deconstruction by twin-screw extrusion with in situ enzymatic hydrolysis via bioextrusion. 61
33581376 2021
3
Chloroplast Calcium Signaling in the Spotlight. 61
32226434 2020
4
A chloroplast-localized mitochondrial calcium uniporter transduces osmotic stress in Arabidopsis. 61
31182842 2019
5
Prolidase deficiency: it looks like systemic lupus erythematosus but it is not. 54
19937054 2010
6
Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer. 54
19638336 2009
7
Prolidase deficiency: the use of topical proline for treatment of leg ulcers. 54
18855790 2008
8
Inborn errors of proline metabolism. 54
18806117 2008
9
Effect of basic fibroblast growth factor, trafermin, on entero-related fistulae, report of two cases. 54
17591067 2007
10
Basic fibroblast growth factor treatment for various types of recalcitrant skin ulcers: reports of nine cases. 54
18058496 2007
11
[Patient waiting time at the Medical and Surgical Emergency Center at the Hôpital des Cadolles: a descriptive study]. 61
17121251 2006
12
Therapeutic outcome of hyperbaric oxygen and basic fibroblast growth factor on intractable skin ulcer in legs: preliminary report. 54
16462352 2006
13
[The nerve growth factor induces cutaneous ulcer healing in "non-responder" tranplanted skin]. 54
16801731 2006
14
Basic fibroblast growth factor treatment for skin ulcerations in scleroderma. 54
16438426 2005
15
Influence of supplemental endoglucanase or xylanase on volatile fatty acid production from ruminant feed by ruminal in vitro cultures. 61
16320781 2005
16
Nerve growth factor, human skin ulcers and vascularization. Our experience. 54
14699983 2004
17
Clinical application of nerve growth factor on human corneal ulcer. 54
12825325 2003
18
Therapeutic apheresis exchange in two patients with prolidase deficiency. 54
12452876 2002
19
Heparin-like inhibitory activity to fibroblast growth factor-2 in wound fluids of patients with chronic skin ulcers and its modulation during wound healing. 54
11679141 2001
20
Transient beneficial effect of GH replacement therapy and topical GH application on skin ulcers in a boy with prolidase deficiency. 54
10886759 2000
21
Patterns of epidermal growth factor receptor, basic fibroblast growth factor and transforming growth factor-beta3 expression in skin with chronic venous insufficiency. 54
9683865 1998
22
Neurotrophins and peripheral neuropathy. 54
8730784 1996
23
Topical treatment of skin ulcers in prolidase deficiency. 54
8919529 1996
24
Four novel PEPD alleles causing prolidase deficiency. 54
8198124 1994
25
Prolidase deficiency: biochemical study of erythrocyte and skin fibroblast prolidase activity in Italian patients. 54
15378943 1994
26
Prolidase deficiency: a multisystemic hereditary disorder. 54
8408817 1993
27
Prolidase deficiency in cultured human fibroblasts: biochemical pathology and iminodipeptide-enhanced growth. 54
1437403 1992

Variations for Mucocutaneous Ulceration, Chronic

ClinVar genetic disease variations for Mucocutaneous Ulceration, Chronic:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 RELA NM_021975.4(RELA):c.559+1G>A SNV Pathogenic 617487 rs1565191003 GRCh37: 11:65427136-65427136
GRCh38: 11:65659665-65659665

Expression for Mucocutaneous Ulceration, Chronic

Search GEO for disease gene expression data for Mucocutaneous Ulceration, Chronic.

Pathways for Mucocutaneous Ulceration, Chronic

Pathways related to Mucocutaneous Ulceration, Chronic according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 NUDT6 NGF FGF2
2
Show member pathways
12.55 NUDT6 NGF FGF2
3
Show member pathways
12.49 RELA NGF FGF2
4 12.16 RELA NGF FGF2
5
Show member pathways
12.08 RELA NGF FGF2
6
Show member pathways
11.84 NUDT6 NGF FGF2
7 11.68 RELA NGF
8
Show member pathways
11.54 NUDT6 NGF FGF2
9
Show member pathways
11.54 RELA NUDT6 NGF FGF2
10 11.33 NGF FGF2
11
Show member pathways
11.27 RELA NGF
12 10.82 NUDT6 NGF FGF2
13 10.54 NUDT6 NGF FGF2

GO Terms for Mucocutaneous Ulceration, Chronic

Biological processes related to Mucocutaneous Ulceration, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 8.96 RELA FGF2
2 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 RELA FGF2

Molecular functions related to Mucocutaneous Ulceration, Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.62 NGF FGF2

Sources for Mucocutaneous Ulceration, Chronic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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