MCID: MCR141
MIFTS: 59

Mucormycosis

Categories: Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Mucormycosis

MalaCards integrated aliases for Mucormycosis:

Name: Mucormycosis 12 73 20 58 3 15 17 70
Zygomycosis 12 73 20 58 3 70 32
Disseminated Mucormycosis 12 32

Characteristics:

Orphanet epidemiological data:

58
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Mucormycosis

CDC : 3 Mucormycosis (sometimes called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These fungi live throughout the environment, particularly in soil and in decaying organic matter, such as leaves, compost piles, or rotten wood.1 People get mucormycosis by coming in contact with the fungal spores in the environment. For example, the lung or sinus forms of the infection can occur after someone breathes in spores. These forms of mucormycosis usually occur in people who have health problems or take medicines that lower the body's ability to fight germs and sickness.3,6 Mucormycosis can also develop on the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Mucormycosis, also known as zygomycosis, is related to aspergillosis and osteomyelitis. An important gene associated with Mucormycosis is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are Innate Immune System and Folate Metabolism. The drugs Voriconazole and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include sinuses, brain and lungs of immunocompromised people, and related phenotypes are fatigue and fever

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection located in sinuses, located in brain, or located in lungs of immunocompromised people, has material basis in Mucorales molds.

Wikipedia : 73 Mucormycosis is any fungal infection caused by fungi in the order Mucorales. Generally, species in the... more...

Related Diseases for Mucormycosis

Diseases related to Mucormycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 823)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 31.1 IFNG CSF3 CSF2 CLEC7A CCR6
2 osteomyelitis 30.7 IFNG CSF3 CRP
3 cavernous sinus thrombosis 30.7 INS CRP
4 orbital cellulitis 30.6 CRP CD4
5 leukemia, acute lymphoblastic 30.6 CYP3A4 CSF3 CSF2 CD4 CCR6
6 candidiasis 30.5 IFNG CYP51A1 CSF2 CLEC7A CARD9
7 ecthyma 30.5 CSF3 CRP
8 neutropenia 30.4 CYP3A4 CSF3 CSF2 CRP ALB
9 fusariosis 30.4 CYP51A1 CSF3 CLEC7A
10 perinatal necrotizing enterocolitis 30.2 CRP CCR6 ALB
11 facial paralysis 30.2 CRP CD4 ALB
12 herpes zoster 30.1 IFNG CD4 CCR6
13 cerebritis 30.1 CRP CD4
14 pyoderma 30.1 CSF3 CRP CCR6
15 pancytopenia 30.0 IFNG CSF3 CSF2 CRP CD4
16 cranial nerve palsy 30.0 CRP CD4 ALB
17 myelodysplastic syndrome 30.0 IFNG CYP3A4 CSF3 CSF2 ALB
18 pneumonia 30.0 IFNG CSF3 CRP ALB
19 panophthalmitis 30.0 IFNG CRP CD4
20 endocarditis 30.0 IFNG CRP ALB
21 respiratory failure 29.9 CRP CD4 CCR6 ALB
22 sporotrichosis 29.9 IFNG CLEC7A CD4 CARD9
23 pulmonary aspergilloma 29.9 CYP51A1 CRP
24 pyelonephritis 29.9 IFNG CSF3 CRP ALB
25 histoplasmosis 29.8 IFNG CLEC7A CD4 CCR6
26 aplastic anemia 29.8 IFNG CYP3A4 CSF3 CSF2 CD4 ALB
27 cellulitis 29.8 INS CSF3 CSF2 CRP CD4 CCR6
28 intestinal perforation 29.8 CRP CD4 ALB
29 panniculitis 29.8 IFNG CSF3 CRP CD4
30 viral pneumonia 29.8 CRP CD4 CCR6
31 folliculitis 29.8 IFNG CD4 CCR6
32 endophthalmitis 29.8 CRP CARD9 ALB
33 bacterial infectious disease 29.8 IFNG CSF3 CSF2 CRP CD4 CCR6
34 conidiobolomycosis 29.8 PPIG CYP51A1 CYP3A4
35 pleural empyema 29.8 CRP CD4 ALB
36 malignant otitis externa 29.8 INS CRP
37 sarcoidosis 1 29.7 IFNG CRP CD4 CCR6
38 uremia 29.7 INS CRP ALB
39 human immunodeficiency virus type 1 29.7 IFNG HSPA5 CYP3A4 CD4
40 neuroretinitis 29.7 CRP CD4
41 pericarditis 29.7 IFNG CRP ALB
42 pharyngitis 29.7 CSF2 CRP CD4
43 common cold 29.7 CSF2 CD4 CCR6 ALB
44 hemopericardium 29.6 CYP3A4 CRP
45 erythema nodosum 29.6 IFNG CSF2 CRP
46 epidural abscess 29.6 CRP CD4 ALB
47 nocardiosis 29.6 IFNG CRP CD4
48 chronic meningitis 29.6 CRP CD4 ALB
49 papilledema 29.6 CRP CD4 ALB
50 chlamydia 29.6 IFNG CSF2 CRP

Graphical network of the top 20 diseases related to Mucormycosis:



Diseases related to Mucormycosis

Symptoms & Phenotypes for Mucormycosis

Human phenotypes related to Mucormycosis:

58 31 (show top 50) (show all 76)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
2 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
3 sinusitis 58 31 frequent (33%) Frequent (79-30%) HP:0000246
4 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
5 unusual skin infection 58 31 frequent (33%) Frequent (79-30%) HP:0032162
6 diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000819
7 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
8 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
9 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
10 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
11 abnormal cranial nerve morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001291
12 atelectasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100750
13 cellulitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100658
14 periorbital edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100539
15 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
16 neutropenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001875
17 hematemesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002248
18 headache 58 31 occasional (7.5%) Occasional (29-5%) HP:0002315
19 mediastinal lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100721
20 premature birth 58 31 occasional (7.5%) Occasional (29-5%) HP:0001622
21 abnormal blistering of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0008066
22 hematological neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0004377
23 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
24 pneumothorax 58 31 occasional (7.5%) Occasional (29-5%) HP:0002107
25 fasciitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100537
26 pulmonary infiltrates 58 31 occasional (7.5%) Occasional (29-5%) HP:0002113
27 pustule 58 31 occasional (7.5%) Occasional (29-5%) HP:0200039
28 visual loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0000572
29 ketoacidosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001993
30 gastritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0005263
31 blurred vision 58 31 occasional (7.5%) Occasional (29-5%) HP:0000622
32 skin plaque 58 31 occasional (7.5%) Occasional (29-5%) HP:0200035
33 periorbital fullness 58 31 occasional (7.5%) Occasional (29-5%) HP:0000629
34 enterocolitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004387
35 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
36 nasal obstruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001742
37 rhinorrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0031417
38 acute infectious pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011949
39 unusual gastrointestinal infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032166
40 parenchymal consolidation 58 31 occasional (7.5%) Occasional (29-5%) HP:0032177
41 air crescent sign 58 31 occasional (7.5%) Occasional (29-5%) HP:0032172
42 ileitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0032564
43 cutaneous wound 58 31 occasional (7.5%) Occasional (29-5%) HP:0032674
44 ptosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000508
45 diplopia 58 31 very rare (1%) Very rare (<4-1%) HP:0000651
46 renal insufficiency 58 31 very rare (1%) Very rare (<4-1%) HP:0000083
47 hepatitis 58 31 very rare (1%) Very rare (<4-1%) HP:0012115
48 retinal detachment 58 31 very rare (1%) Very rare (<4-1%) HP:0000541
49 proptosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000520
50 epistaxis 58 31 very rare (1%) Very rare (<4-1%) HP:0000421

GenomeRNAi Phenotypes related to Mucormycosis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 9.68 CLEC7A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 9.68 CLEC7A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.68 CLEC7A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.68 CLEC7A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.68 CLEC7A CYP51A1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.68 CLEC7A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.68 CD4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 9.68 CLEC7A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.68 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 9.68 CLEC7A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 9.68 CLEC7A
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.68 CLEC7A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.68 CYP51A1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.68 CLEC7A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.68 CRP
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-54 9.68 CD4
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.68 CRP
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.68 CLEC7A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.68 CLEC7A CRP
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 9.68 CLEC7A CYP51A1

MGI Mouse Phenotypes related to Mucormycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.73 ALB CARD9 CCR6 CD4 CLEC6A CLEC7A
2 digestive/alimentary MP:0005381 9.7 ALB CD4 CLEC7A CYP51A1 HSPA5 IFNG
3 renal/urinary system MP:0005367 9.17 ALB CLEC6A CSF2 CSF3 HSPA5 IFNG

Drugs & Therapeutics for Mucormycosis

Drugs for Mucormycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved Phase 3 137234-62-9 71616
2 Cytochrome P-450 CYP3A Inhibitors Phase 3
3 Cytochrome P-450 Enzyme Inhibitors Phase 3
4 Hormone Antagonists Phase 3
5 Hormones Phase 3
6
Iron Approved Phase 2 7439-89-6 23925 29936
7
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381 214348
8
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
9
deoxycholic acid Approved Phase 2 83-44-3 222528
10 Chelating Agents Phase 2
11 Iron Chelating Agents Phase 2
12 Amebicides Phase 2
13 Antiparasitic Agents Phase 2
14 Anti-Bacterial Agents Phase 2
15 Liposomal amphotericin B Phase 2
16 Antiprotozoal Agents Phase 2
17 Gastrointestinal Agents Phase 2
18 Pharmaceutical Solutions Phase 2
19 Amphotericin B, deoxycholate drug combination Phase 2
20 Vaccines Phase 2
21
Clotrimazole Approved, Vet_approved 23593-75-1 2812
22
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
23
Isavuconazole Approved, Investigational 241479-67-4
24 Anti-Infective Agents
25 Antifungal Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Phase 3, Multi-center, Open Label Study to Evaluate Safety and Efficacy of AK1820 for Treatment of Adult Japanese Patients With Deep Mycosis Active, not recruiting NCT03471988 Phase 3 AK1820;Voriconazole
2 Treatment of Rhino-Sinusal Mucormycosis Through Transnasal Endoscopic Surgery Extended to the Skull Base. Unknown status NCT02226705 Phase 2
3 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
4 AMBIZYGO: Efficacy of High Dose [10 mg/kg/j] Liposomal Amphotericin B (Ambisome)Efficacy in Initial Zygomycosis Treatment:Phase II Trial Completed NCT00467883 Phase 2 Liposomal Amphotericin B
5 A Phase 2, Open-Label, Non-Comparative, Multicenter Study to Evaluate the Safety and Tolerability, Efficacy and Pharmacokinetics of Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Subjects Recruiting NCT03816176 Phase 2 Isavuconazonium sulfate;Isavuconazonium sulfate
6 A Randomized Controlled Trial of Combined Inhalational With Intravenous Amphotericin B in Comparison With Intravenous Amphotericin B Alone for Treatment of Pulmonary Mucormycosis Recruiting NCT04502381 Phase 2 Inhaled amp B deoxycholate+intravenous liposomal amp B;Intravenous liposomal amphotericin B alone
7 Mucormycosis in ICU: A French Multicenter Cohort Study Unknown status NCT03387696
8 Emerging Invasive Fungal Infections in Critically Ill Patients: Epidemiological Trends, Clinical Features and Outcomes Completed NCT04647539
9 Characterization of Fungal Infections in COVID-19 Infected and Mechanically Ventilated Patients in ICU Completed NCT04368221
10 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934
11 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
12 Multicenter Observational Study on Epidemiology, Treatment and Outcome of Mucormycosis in India Completed NCT03429023
13 A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Cresemba to Evaluate Safety and Effectiveness in Patients With Invasive Aspergillosis or Invasive Mucormycosis in Korea Not yet recruiting NCT04744454 Isauvuconazole group
14 Patterns of Real-World Isavuconazole Use, Effectiveness, Safety, and Healthcare Resource Utilization-a Retrospective Chart Review Study of Patients With Mucormycosis or Invasive Aspergillosis (PRISMA) Not yet recruiting NCT04550936 Isavuconazole

Search NIH Clinical Center for Mucormycosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Itraconazole

Genetic Tests for Mucormycosis

Anatomical Context for Mucormycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Mucormycosis:

19
Sinuses, Brain, Lungs Of Immunocompromised People

MalaCards organs/tissues related to Mucormycosis:

40
Myeloid, Bone Marrow, Colon, Skin, Brain, Eye, Tongue

Publications for Mucormycosis

Articles related to Mucormycosis:

(show top 50) (show all 4398)
# Title Authors PMID Year
1
Fulminant Rhizomucor pusillus mucormycosis during anti-leukemic treatment with blinatumomab in a child: A case report and review of the literature. 61
33489743 2021
2
COVID-19 and orbital mucormycosis. 61
33727483 2021
3
Mucormycosis with orbital compartment syndrome in a patient with COVID-19. 61
32972795 2021
4
'Mass-Like' Appearance of Pulmonary Mucormycosis in Chronic Granulomatous Disease: An Imaging Observation. 61
33400136 2021
5
Rhizomucor hepatosplenic abscesses in a patient with renal and pancreatic transplantation. 61
33682478 2021
6
A rare case of parotid mucormycosis diagnosed on aspiration cytology. 61
33554465 2021
7
[Imaging findings in rhino-oro-facial mucormycosis: black turbinate sign and other similar features]. 61
33302309 2021
8
Thoracic mucormycosis in immunocompetent patients. 61
33470008 2021
9
Mucormycosis at a tertiary-care center in Mexico. A 35-year retrospective study of 214 cases. 61
33253454 2021
10
Gastrointestinal Zygomycosis in a Preterm Neonate Associated With Contaminated Probiotics. 61
33464011 2021
11
Breakthrough Mucormycosis Developing on Mucorales-Active Antifungals Portrays a Poor Prognosis in Patients with Hematologic Cancer. 61
33802827 2021
12
Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome. 61
33229953 2021
13
Taking a step down on the reconstruction ladder for head and neck reconstruction during the COVID-19 pandemic. 61
33685447 2021
14
Secondary infection with rhino-orbital cerebral mucormycosis associated with COVID-19. 61
33752571 2021
15
Cutaneous mucormycosis of the lower extremity leading amputation in two diabetic patients. 61
33657778 2021
16
Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction. 61
33678746 2021
17
Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosis. 61
33761547 2021
18
Rhinocerebral mucormycosis to the rise? The impact of the worldwide diabetes epidemic. 61
33531184 2021
19
Epidemiology of Mucormycosis in India. 61
33806386 2021
20
Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis. 61
33462434 2021
21
Fulminant mucormycosis complicating coronavirus disease 2019 (COVID-19). 61
33713565 2021
22
In vivo and in vitro impairments in T helper cell and neutrophil responses against Mucor irregularis in Card9 knockout mice. 61
33649049 2021
23
Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile. 61
33259981 2021
24
The reverse halo sign and spontaneous pneumothorax due to pulmonary mucormycosis. 61
33532075 2021
25
Osseointegrated Implants for Orbito-Facial Prostheses: Common Complications and Solutions. 61
33741879 2021
26
Opportunistic Invasive Fungal Infections Mimicking Progression of Non-Small-Cell Lung Cancer. 61
33168426 2021
27
A closer look at pathogenesis of cerebral mucormycosis in diabetic condition: A mini review. 61
33448040 2021
28
Immune Checkpoint Blockade for Aspergillosis and Mucormycosis Coinfection. 61
33604513 2021
29
Guidance on Imaging for Invasive Pulmonary Aspergillosis and Mucormycosis: From the Imaging Working Group for the Revision and Update of the Consensus Definitions of Fungal Disease from the EORTC/MSGERC. 61
33709131 2021
30
Liver Transplantation in Patients With Pretransplant Aspergillus Colonization: Is It Safe to Proceed? 61
32301905 2021
31
SARS-CoV-2, Uncontrolled Diabetes and Corticosteroids-An Unholy Trinity in Invasive Fungal Infections of the Maxillofacial Region? A Retrospective, Multi-centric Analysis. 61
33716414 2021
32
Role of flexible bronchoscopy in the diagnosis of invasive fungal infections. 61
33719109 2021
33
Poor outcome associated with mucormycosis in critically ill hematological patients: results of a multicenter study. 61
33569700 2021
34
Chasing the culprit in shadow - Sinonasal mucormycosis in an immunocompetent host. 61
33567999 2021
35
Mucormycosis originated total maxillary and cranial base osteonecrosis: a possible misdiagnosis to malignancy. 61
33579255 2021
36
Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. 61
33575424 2021
37
An implant-supported prosthetic rehabilitation of a patient with a bilateral subtotal maxillectomy defect secondary to rhino-orbital-cerebral mucormycosis: A clinical report of a graftless approach. 61
33551135 2021
38
Managing mucormycosis in diabetic patients: A case report with critical review of the literature. 61
33583133 2021
39
Disseminated Mucormycosis in Immunocompromised Children: Are New Antifungal Agents Making a Difference? A Multicenter Retrospective Study. 61
33668990 2021
40
Pulmonary mucormycosis masquerading as endobronchial tumour in an immunocompetent pregnant young lady. 61
33364028 2021
41
Imaging features of rhinocerebral mucormycosis: from onset to vascular complications. 61
33615823 2021
42
Pulmonary mucormycosis causing a mycotic pulmonary artery aneurysm. 61
33626876 2021
43
The disease burden of mucormycosis in Japan: results from a systematic literature review and retrospective database study. 61
33143482 2021
44
Neuromucormycosis of Posterior Tibial Nerve: A Rare Presentation of Mucormycosis. 61
33527864 2021
45
A Mucoralean White Collar-1 Photoreceptor Controls Virulence by Regulating an Intricate Gene Network during Host Interactions. 61
33672193 2021
46
The RNAi Mechanism Regulates a New Exonuclease Gene Involved in the Virulence of Mucorales. 61
33668930 2021
47
Mucor in a Viral Land: A Tale of Two Pathogens. 61
33463566 2021
48
Interlaboratory evaluation of Mucorales PCR assays for testing serum specimens: A study by the fungal PCR Initiative and the Modimucor study group. 61
32534456 2021
49
Fatal Cutaneous Zygomycosis caused by Saksaenea Vasiformis. 61
33527819 2021
50
A physiologically based pharmacokinetic analysis to predict the pharmacokinetics of intravenous isavuconazole in patients with or without hepatic impairment. 61
33619060 2021

Variations for Mucormycosis

Expression for Mucormycosis

Search GEO for disease gene expression data for Mucormycosis.

Pathways for Mucormycosis

GO Terms for Mucormycosis

Cellular components related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.26 INS HSPA5 CD4 ALB
2 intracellular membrane-bounded organelle GO:0043231 9.1 PPIG HSPA5 CYP51A1 CYP3A4 CYP2C19 CSF2

Biological processes related to Mucormycosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 INS IFNG CSF3 CSF2 CLEC7A
2 positive regulation of gene expression GO:0010628 9.85 INS IFNG CSF2 CRP CLEC7A
3 immune response GO:0006955 9.83 IFNG CSF3 CSF2 CD4 CCR6
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CSF3 CLEC7A CD4
5 positive regulation of interleukin-6 production GO:0032755 9.71 IFNG CLEC7A CARD9
6 positive regulation of tumor necrosis factor production GO:0032760 9.7 IFNG CLEC7A CARD9
7 negative regulation of amyloid-beta clearance GO:1900222 9.51 IFNG CYP51A1
8 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.49 CSF2 CD4
9 positive regulation of respiratory burst GO:0060267 9.4 INS CLEC7A
10 heterocycle metabolic process GO:0046483 9.37 CYP3A4 CYP2C19
11 positive regulation of cytokine production GO:0001819 9.33 INS IFNG CLEC6A
12 positive regulation of killing of cells of other organism GO:0051712 9.32 IFNG CLEC7A
13 monoterpenoid metabolic process GO:0016098 9.26 CYP3A4 CYP2C19
14 positive regulation of interleukin-23 production GO:0032747 8.96 IFNG CSF2
15 macrophage differentiation GO:0030225 8.8 IFNG CSF2 CD4

Molecular functions related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.43 CYP51A1 CYP3A4 CYP2C19
2 enzyme binding GO:0019899 9.35 HSPA5 CYP3A4 CYP2C19 CSF3 CD4
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP51A1 CYP3A4 CYP2C19
4 oxygen binding GO:0019825 8.8 CYP3A4 CYP2C19 ALB

Sources for Mucormycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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