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MCID: MCR141
MIFTS: 51

Mucormycosis

Categories: Immune diseases, Infectious diseases, Oral diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mucormycosis

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MalaCards integrated aliases for Mucormycosis:

Name: Mucormycosis 12 77 60 15 17 3
Zygomycosis 12 77 54 60 3
Disseminated Mucormycosis 12

Characteristics:

Orphanet epidemiological data:

60
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases Immune diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8485
MESH via Orphanet 46 D009091 D020096
UMLS via Orphanet 75 C0026718 C0043541
Orphanet 60 ORPHA73263
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Summaries for Mucormycosis

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CDC : 3 Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people with weakened immune systems and can occur in nearly any part of the body. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air, or the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Mucormycosis, also known as zygomycosis, is related to aspergillosis and acquired immunodeficiency syndrome. An important gene associated with Mucormycosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Amoebiasis. The drugs Miconazole and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver, and related phenotype is renal/urinary system.

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection located in sinuses, located in brain, or located in lungs of immunocompromised people, has material basis in Mucorales molds.

Wikipedia : 77 Mucormycosis is any fungal infection caused by fungi in the order Mucorales. Generally, species in the... more...

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Related Diseases for Mucormycosis

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Diseases related to Mucormycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.8 CSF2 IFNG
2 acquired immunodeficiency syndrome 30.1 CSF2 IFNG
3 carotid artery thrombosis 29.9 CSF2 IFNG
4 chronic granulomatous disease 29.4 CSF2 IFNG
5 leukemia 10.6
6 lymphocytic leukemia 10.4
7 diabetes mellitus 10.4
8 diabetes mellitus, ketosis-prone 10.3
9 thrombosis 10.3
10 leukemia, acute lymphoblastic 10.3
11 lymphoma 10.2
12 osteomyelitis 10.2
13 large granular lymphocyte leukemia 10.2 CSF2 IFNG
14 trichosporonosis 10.2 CSF2 IFNG
15 candida glabrata 10.2 CSF2 IFNG
16 human t-cell leukemia virus type 2 10.2 CSF2 IFNG
17 leukemia, acute myeloid 10.2
18 myeloid leukemia 10.2
19 meconium aspiration syndrome 10.2 CSF2 IFNG
20 cyclic neutropenia 10.2 CSF2 IFNG
21 cytomegalovirus retinitis 10.1 CSF2 IFNG
22 cryptococcal meningitis 10.1 CSF2 IFNG
23 invasive aspergillosis 10.1
24 smallpox 10.1 CSF2 IFNG
25 langerhans cell histiocytosis 10.1 CSF2 IFNG
26 pulmonary sarcoidosis 10.1 CSF2 IFNG
27 systemic lupus erythematosus 10.1
28 lupus erythematosus 10.1
29 paranasal sinus disease 10.1 IFNG RHNO1
30 opportunistic mycosis 10.1 IFNG RHNO1
31 acute leukemia 10.1
32 acute lymphocytic leukemia 10.1
33 candidiasis 10.1
34 pneumonia 10.1
35 ethmoid sinusitis 10.1 CSF2 RHNO1
36 monocytic leukemia 10.1 CSF2 IFNG
37 upper respiratory tract disease 10.1 IFNG RHNO1
38 burns 10.0
39 sarcoidosis 1 10.0 CSF2 IFNG
40 liver cirrhosis 10.0
41 cellulitis 10.0
42 respiratory system disease 10.0 CSF2 IFNG
43 leukemia, chronic lymphocytic 2 10.0
44 leukemia, chronic lymphocytic 10.0
45 enterocolitis 10.0
46 aplastic anemia 10.0
47 myelodysplastic syndrome 10.0
48 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
49 neutropenia 10.0
50 cavernous sinus thrombosis 10.0

Graphical network of the top 20 diseases related to Mucormycosis:



Diseases related to Mucormycosis
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Symptoms & Phenotypes for Mucormycosis

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MGI Mouse Phenotypes related to Mucormycosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 CSF2 HSPA5 IFNG TREH
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Drugs & Therapeutics for Mucormycosis

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Drugs for Mucormycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
2
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 171228-49-2 147912
3 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
7 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
9 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Antifungal Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
12
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
13
Isavuconazole Approved, Investigational Phase 3,Phase 2 241479-67-4
14 Cytochrome P-450 CYP3A Inhibitors Phase 3,Not Applicable
15 Pharmaceutical Solutions Phase 3
16
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
17
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
18
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
19 Anti-Bacterial Agents Phase 2
20 Liposomal amphotericin B Phase 2
21 Chelating Agents Phase 2
22 Iron Chelating Agents Phase 2
23
Fluconazole Approved, Investigational Not Applicable 86386-73-4 3365
24 Cytochrome P-450 CYP2C19 Inhibitors Not Applicable
25 Cytochrome P-450 CYP2C9 Inhibitors Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
2 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
3 Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis Recruiting NCT03471988 Phase 3 AK1820;Voriconazole
4 Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis Unknown status NCT02226705 Phase 2
5 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
6 Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment Completed NCT00467883 Phase 2 Liposomal Amphotericin B
7 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
8 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
9 A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants Not yet recruiting NCT03816176 Phase 2 Isavuconazonium sulfate
10 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934 Not Applicable
11 Descriptive Epidemiology on Management of Mucormycosis Completed NCT03429023
12 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
13 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
14 Mucormycosis in ICU Recruiting NCT03387696
15 PTX3-targeted Antifungal Prophylaxis Recruiting NCT03828773 Not Applicable Posaconazole;Fluconazole
16 Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis Not yet recruiting NCT03569904

Search NIH Clinical Center for Mucormycosis

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Genetic Tests for Mucormycosis

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Anatomical Context for Mucormycosis

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MalaCards organs/tissues related to Mucormycosis:

42
Lung, Brain, Liver, Skin, Bone, Kidney, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Mucormycosis:

20
Brain, Sinuses, Lungs Of Immunocompromised People
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Publications for Mucormycosis

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Articles related to Mucormycosis:

(show top 50) (show all 2071)
# Title Authors Year
1
Successful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis. ( 30705813 )
2019
2
Concurrent cerebral aspergillosis and abdominal mucormycosis during Ibrutinib therapy for chronic lymphocytic leukemia. ( 30703527 )
2019
3
Contrasts between mucormycosis and aspergillosis in oncohematological patients. ( 30816977 )
2019
4
Rhino-orbital Mucormycosis presenting as facial cellulitis in a patient with high-risk acute myeloid leukemia in relapse. ( 30686650 )
2019
5
The contemporary management and clinical outcomes of mucormycosis: a systematic review and meta-analysis of case reports. ( 30639526 )
2019
6
An Emergent Entity: Indolent Mucormycosis of the Paranasal Sinuses. A Multicenter Study. ( 30647791 )
2019
7
Isolated Renal Mucormycosis in Immunocompetent Hosts: Clinical Spectrum and Management Approach. ( 30652661 )
2019
8
Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B. ( 30666543 )
2019
9
Pulmonary mucormycosis associated with medical marijuana use. ( 30671341 )
2019
10
Rare Presentation of Mucormycosis in Aplastic Anaemia: Isolated Hepatic Mucormycosis. ( 30684143 )
2019
11
Mucormycosis- a clinicoepidemiological review of cases over 10 years. ( 30685896 )
2019
12
Managing mucormycosis in a resource-limited setting: challenges and possible solutions. ( 30691355 )
2019
13
Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report. ( 30691617 )
2019
14
Rhino-orbital Mucormycosis. ( 30719474 )
2019
15
Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology. ( 30770712 )
2019
16
Severe facial necrosis in a type 1 diabetic patient secondary to mucormycosis masquerading as an internal maxillary artery occlusion: a case report. ( 30795757 )
2019
17
An unusual cause of massive upper gastrointestinal bleeding-gastric mucormycosis. ( 30800331 )
2019
18
Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors. ( 30816980 )
2019
19
Cutaneous Mucormycosis in Solid Organ Transplant Recipients after Hurricane Harvey: Short- and Long-term Management. ( 30859029 )
2019
20
Disease Entities in Mucormycosis. ( 30875744 )
2019
21
Successful Mandibular Mucormycosis Treatment in the Severely Neutropenic Patient. ( 30878590 )
2019
22
Fatal renal mucormycosis with Apophysomyces elegans in an apparently healthy male. ( 30879364 )
2019
23
Molecular Strategies to Diagnose Mucormycosis. ( 30897709 )
2019
24
Mucormycosis in Burn Patients. ( 30901836 )
2019
25
Global Epidemiology of Mucormycosis. ( 30901907 )
2019
26
Skull Base Mucormycosis in an Immunocompetent Patient: A Case Report and Literature Review. ( 30906732 )
2019
27
Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess. ( 30915243 )
2019
28
Ruptured Mycotic Aneurysm of the Distal Circulation in a Patient with Mucormycosis Without Direct Skull Base Extension: Case Report. ( 29800469 )
2019
29
Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association. ( 30338581 )
2019
30
Treatment of cerebral mucormycosis with drug therapy alone: A case report. ( 30425919 )
2019
31
Breaking the mold: A case of pulmonary mucormycosis treated with isavuconazole. ( 30560048 )
2019
32
Disseminated mucormycosis in an adolescent kidney transplant recipient. ( 30606422 )
2019
33
Correction to: Mucormycosis in hospitalized patients at a tertiary care center in Lebanon: a case series. ( 30617837 )
2019
34
In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Galleria mellonella Model of Mucormycosis. ( 30626083 )
2019
35
Case Series of Cutaneous Mucormycosis in Setting of Herpesviridae Infection. ( 30633321 )
2019
36
An instance of excellent response of subcutaneous zygomycosis to itraconazole monotherapy. ( 30859059 )
2019
37
Cutaneous Mucormycosis Following a Bullous Pemphigoid Flare in a Chronic Lymphocytic Leukemia Patient on Ibrutinib. ( 29760835 )
2018
38
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy. ( 29750016 )
2018
39
How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients. ( 29975240 )
2018
40
Management of Recurrent Rhinomaxillary Mucormycosis and Nasal Myiasis in an Uncontrolled Diabetic Patient: A Systematic Approach. ( 29744327 )
2018
41
Mucormycosis Osteomyelitis of the Hand. ( 29934077 )
2018
42
Neonatal Acute Liver Failure Associated with Angioinvasive Hepatic Zygomycosis. ( 30595071 )
2018
43
Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease. ( 30148059 )
2018
44
Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient. ( 29188178 )
2018
45
Invasive pulmonary mucormycosis and aspergillosis in a patient with decompensated hepatic cirrhosis. ( 29560305 )
2018
46
Primary Cutaneous Mucormycosis in a Beta-Thalassemia Patient. ( 30369766 )
2018
47
Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma. ( 30320719 )
2018
48
Primary cutaneous mucormycosis as a complication of erosive dermatitis: two cases. ( 29171398 )
2018
49
Pulmonary mucormycosis in an adolescent female with type 1 diabetes mellitus. ( 30524955 )
2018
50
Successful Treatment of Concurrent Mucormycosis and Diffuse Alveolar Hemorrhage in a Patient With Newly Diagnosed Systemic Lupus Erythematosus. ( 30207572 )
2018
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Variations for Mucormycosis

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Expression for Mucormycosis

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Search GEO for disease gene expression data for Mucormycosis.
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Pathways for Mucormycosis

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Pathways related to Mucormycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.54 CSF2 IFNG
2
Amoebiasis 38
11.44 CSF2 IFNG
3
Rheumatoid arthritis 38
11.39 CSF2 IFNG
4
Salmonella infection (KEGG) 38
11.34 CSF2 IFNG
5
Glucocorticoid receptor regulatory network 1
11.28 CSF2 IFNG
6
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.2 CSF2 IFNG
7
Dendritic Cells Developmental Lineage Pathway 66
11.13 CSF2 IFNG
8
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.01 CSF2 IFNG
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.76 CSF2 IFNG
10
Cytokines and Inflammatory Response 1
10.09 CSF2 IFNG
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GO Terms for Mucormycosis

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Biological processes related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.26 HSPA5 KIDINS220
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 CSF2 IFNG
3 cellular response to nerve growth factor stimulus GO:1990090 8.96 HSPA5 KIDINS220
4 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG
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Sources for Mucormycosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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