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MCID: MCR141
MIFTS: 51

Mucormycosis

Categories: Immune diseases, Infectious diseases, Oral diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mucormycosis

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MalaCards integrated aliases for Mucormycosis:

Name: Mucormycosis 12 77 54 60 3 15 17
Zygomycosis 12 77 54 60 3
Disseminated Mucormycosis 12

Characteristics:

Orphanet epidemiological data:

60
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases Immune diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8485
MESH via Orphanet 46 D009091 D020096
UMLS via Orphanet 75 C0026718 C0043541
Orphanet 60 ORPHA73263
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Summaries for Mucormycosis

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CDC : 3 Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people with weakened immune systems and can occur in nearly any part of the body. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air, or the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Mucormycosis, also known as zygomycosis, is related to aspergillosis and acquired immunodeficiency syndrome. An important gene associated with Mucormycosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Amoebiasis. The drugs Posaconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotype is renal/urinary system.

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection located in sinuses, located in brain, or located in lungs of immunocompromised people, has material basis in Mucorales molds.

Wikipedia : 77 Mucormycosis is any fungal infection caused by fungi in the order Mucorales. Generally, species in the... more...

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Related Diseases for Mucormycosis

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Diseases related to Mucormycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.9 CSF2 IFNG
2 acquired immunodeficiency syndrome 30.1 CSF2 IFNG
3 carotid artery thrombosis 29.9 CSF2 IFNG
4 chronic granulomatous disease 29.4 CSF2 IFNG
5 leukemia 10.6
6 lymphocytic leukemia 10.4
7 diabetes mellitus 10.4
8 diabetes mellitus, ketosis-prone 10.3
9 thrombosis 10.3
10 leukemia, acute lymphoblastic 10.3
11 lymphoma 10.2
12 osteomyelitis 10.2
13 large granular lymphocyte leukemia 10.2 CSF2 IFNG
14 trichosporonosis 10.2 CSF2 IFNG
15 leukemia, acute myeloid 10.2
16 myeloid leukemia 10.2
17 candida glabrata 10.2 CSF2 IFNG
18 human t-cell leukemia virus type 2 10.2 CSF2 IFNG
19 meconium aspiration syndrome 10.2 CSF2 IFNG
20 cyclic neutropenia 10.2 CSF2 IFNG
21 cytomegalovirus retinitis 10.2 CSF2 IFNG
22 cryptococcal meningitis 10.1 CSF2 IFNG
23 invasive aspergillosis 10.1
24 smallpox 10.1 CSF2 IFNG
25 langerhans cell histiocytosis 10.1 CSF2 IFNG
26 systemic lupus erythematosus 10.1
27 lupus erythematosus 10.1
28 pulmonary sarcoidosis 10.1 CSF2 IFNG
29 paranasal sinus disease 10.1 IFNG RHNO1
30 opportunistic mycosis 10.1 IFNG RHNO1
31 acute leukemia 10.1
32 acute lymphocytic leukemia 10.1
33 candidiasis 10.1
34 pneumonia 10.1
35 ethmoid sinusitis 10.1 CSF2 RHNO1
36 monocytic leukemia 10.1 CSF2 IFNG
37 burns 10.1
38 neutropenia 10.1
39 upper respiratory tract disease 10.1 IFNG RHNO1
40 sarcoidosis 1 10.0 CSF2 IFNG
41 liver cirrhosis 10.0
42 cellulitis 10.0
43 carotid artery occlusion 10.0
44 respiratory system disease 10.0 CSF2 IFNG
45 enterocolitis 10.0
46 aplastic anemia 10.0
47 myelodysplastic syndrome 10.0
48 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
49 cavernous sinus thrombosis 10.0
50 perinatal necrotizing enterocolitis 10.0

Graphical network of the top 20 diseases related to Mucormycosis:



Diseases related to Mucormycosis
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Symptoms & Phenotypes for Mucormycosis

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MGI Mouse Phenotypes related to Mucormycosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 CSF2 HSPA5 IFNG TREH
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Drugs & Therapeutics for Mucormycosis

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Drugs for Mucormycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 171228-49-2 147912
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22916-47-8 4189
3 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
5 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
6 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
8 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Antifungal Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
12
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
13
Isavuconazole Approved, Investigational Phase 3,Phase 2 241479-67-4
14 Cytochrome P-450 CYP3A Inhibitors Phase 3,Not Applicable
15 Pharmaceutical Solutions Phase 3
16
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
17
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 27284 23925
18
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
19 Iron Chelating Agents Phase 2
20 Chelating Agents Phase 2
21 Anti-Bacterial Agents Phase 2
22 Liposomal amphotericin B Phase 2
23
Fluconazole Approved, Investigational Not Applicable 86386-73-4 3365
24 Cytochrome P-450 CYP2C19 Inhibitors Not Applicable
25 Cytochrome P-450 CYP2C9 Inhibitors Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
2 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
3 Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis Recruiting NCT03471988 Phase 3 AK1820;Voriconazole
4 Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis Unknown status NCT02226705 Phase 2
5 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
6 Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment Completed NCT00467883 Phase 2 Liposomal Amphotericin B
7 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
8 A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants Recruiting NCT03816176 Phase 2 Isavuconazonium sulfate
9 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934 Not Applicable
10 Descriptive Epidemiology on Management of Mucormycosis Completed NCT03429023
11 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
12 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
13 Mucormycosis in ICU Recruiting NCT03387696
14 Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis Recruiting NCT03569904
15 PTX3-targeted Antifungal Prophylaxis Recruiting NCT03828773 Not Applicable Posaconazole;Fluconazole

Search NIH Clinical Center for Mucormycosis

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Genetic Tests for Mucormycosis

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Anatomical Context for Mucormycosis

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MalaCards organs/tissues related to Mucormycosis:

42
Lung, Liver, Bone, Brain, Kidney, Skin, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Mucormycosis:

20
Brain, Sinuses, Lungs Of Immunocompromised People
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Publications for Mucormycosis

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Articles related to Mucormycosis:

(show top 50) (show all 2581)
# Title Authors Year
1
Rhinocerebral mucormycosis associated with actinomycosis in a diabetic patient: A rare presentation. ( 30967740 )
2019
2
Histopathological evaluation of a rare fulminant case of contemporaneous mucormycosis, aspergillosis and actinomycosis. ( 31110432 )
2019
3
Successful treatment of severe aplastic anemia with syngeneic stem cell transplantation in the setting of active disseminated mucormycosis. ( 30705813 )
2019
4
Concurrent cerebral aspergillosis and abdominal mucormycosis during ibrutinib therapy for chronic lymphocytic leukaemia. ( 30703527 )
2019
5
Contrasts between mucormycosis and aspergillosis in oncohematological patients. ( 30816977 )
2019
6
Correlation of fungal cultures from non-sterile sites and Galactomannan assay with the diagnosis of aspergillosis and mucormycosis based on sterile culture results and histopathologic findings. ( 30938208 )
2019
7
Diagnosis of Rhinocerebral Mucormycosis by Treatment of Cavernous Right Internal Carotid Artery Occlusion With Mechanical Thrombectomy: Special Case Presentation and Literature Review. ( 30972005 )
2019
8
Rhino-orbital Mucormycosis presenting as facial cellulitis in a patient with high-risk acute myeloid leukemia in relapse. ( 30686650 )
2019
9
Fatal rhinocerebral mucormycosis in a patient with ulcerative colitis receiving azathioprine and corticosteroid. ( 31049457 )
2019
10
Unsuspected invasive gastrointestinal mucormycosis masquerading as inflammatory bowel disease: A pathologist's perspective. ( 30971571 )
2019
11
Rare Presentation of Mucormycosis in Aplastic Anaemia: Isolated Hepatic Mucormycosis. ( 30684143 )
2019
12
Mucormycosis-A clinicoepidemiological review of cases over 10 years. ( 30685896 )
2019
13
Managing mucormycosis in a resource-limited setting: challenges and possible solutions. ( 30691355 )
2019
14
Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report. ( 30691617 )
2019
15
Rhino-orbital Mucormycosis. ( 30719474 )
2019
16
Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology. ( 30770712 )
2019
17
Severe facial necrosis in a type 1 diabetic patient secondary to mucormycosis masquerading as an internal maxillary artery occlusion: a case report. ( 30795757 )
2019
18
An unusual cause of massive upper gastrointestinal bleeding-gastric mucormycosis. ( 30800331 )
2019
19
Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors. ( 30816980 )
2019
20
Cutaneous Mucormycosis in Solid Organ Transplant Recipients after Hurricane Harvey: Short- and Long-term Management. ( 30859029 )
2019
21
Disease Entities in Mucormycosis. ( 30875744 )
2019
22
Successful Mandibular Mucormycosis Treatment in the Severely Neutropenic Patient. ( 30878590 )
2019
23
Fatal renal mucormycosis with Apophysomyces elegans in an apparently healthy male. ( 30879364 )
2019
24
Molecular Strategies to Diagnose Mucormycosis. ( 30897709 )
2019
25
Mucormycosis in Burn Patients. ( 30901836 )
2019
26
Global Epidemiology of Mucormycosis. ( 30901907 )
2019
27
Skull Base Mucormycosis in an Immunocompetent Patient: A Case Report and Literature Review. ( 30906732 )
2019
28
Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess. ( 30915243 )
2019
29
Bowel infarction due to mucormycosis in an immunocompromised patient. ( 30929970 )
2019
30
Animal Models to Study Mucormycosis. ( 30934788 )
2019
31
Teaching NeuroImages: Mucormycosis-associated vasculitis: A new sequence to show an old invasive infection. ( 30962306 )
2019
32
Overview And Outcome Of Mucormycosis Among Children With Cancer; Report From The Children's Cancer Hospital Egypt. ( 30983046 )
2019
33
Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy. ( 31007963 )
2019
34
Rhino-orbital-cerebral mucormycosis. ( 31015350 )
2019
35
Factors affecting surgical resection and treatment outcomes in patients with pulmonary mucormycosis. ( 31019778 )
2019
36
Mediastinal Mucormycosis: Case Report, Review of Literature, and Treatment with Continuous Liposomal Amphotericin B Irrigation. ( 31044442 )
2019
37
Mucormycosis: More than meets the eye! ( 31047865 )
2019
38
Disseminated mucormycosis. ( 31062048 )
2019
39
Invasive Oral Tongue Mucormycosis Rapidly Presenting After Orthotopic Liver Transplant. ( 31079483 )
2019
40
Ruptured Mycotic Aneurysm of the Distal Circulation in a Patient with Mucormycosis Without Direct Skull Base Extension: Case Report. ( 29800469 )
2019
41
Mucormycosis Osteomyelitis of the Hand. ( 29934077 )
2019
42
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports. ( 30036666 )
2019
43
Isavuconazole in a Successful Combination Treatment of Disseminated Mucormycosis in a Child with Acute Lymphoblastic Leukaemia and Generalized Haemochromatosis: A Case Report and Review of the Literature. ( 30039238 )
2019
44
Autopsy-confirmed fulminant mucormycosis: a skin lesion revealing multiple organ dissemination. ( 30046873 )
2019
45
Invasive hepatic mucormycosis: A case report and review of the literature. ( 30057341 )
2019
46
Combined Medical and Surgical Management of Hepatic Mucormycosis in an Adult with Acute Myeloid Leukemia: Case Report and Review of the Literature. ( 30062389 )
2019
47
Cutaneous Mucormycosis by Saksenaea vasiformis: An Unusual Case Report and Review of Literature. ( 30062390 )
2019
48
A prospective multicenter study on mucormycosis in India: Epidemiology, diagnosis, and treatment. ( 30085158 )
2019
49
Cutaneous mucormycosis caused by Mucor irregularis in a patient with CARD9 deficiency. ( 30187457 )
2019
50
Invasive mucormycosis in children with cancer: A retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association. ( 30338581 )
2019
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Variations for Mucormycosis

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Expression for Mucormycosis

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Search GEO for disease gene expression data for Mucormycosis.
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Pathways for Mucormycosis

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Pathways related to Mucormycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.54 CSF2 IFNG
2
Amoebiasis 38
11.44 CSF2 IFNG
3
Rheumatoid arthritis 38
11.39 CSF2 IFNG
4
Salmonella infection (KEGG) 38
11.34 CSF2 IFNG
5
Glucocorticoid receptor regulatory network 1
11.28 CSF2 IFNG
6
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.2 CSF2 IFNG
7
Dendritic Cells Developmental Lineage Pathway 66
11.13 CSF2 IFNG
8
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.01 CSF2 IFNG
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.76 CSF2 IFNG
10
Cytokines and Inflammatory Response 1
10.09 CSF2 IFNG
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GO Terms for Mucormycosis

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Biological processes related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron projection development GO:0010976 9.26 HSPA5 KIDINS220
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 CSF2 IFNG
3 cellular response to nerve growth factor stimulus GO:1990090 8.96 HSPA5 KIDINS220
4 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG
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Sources for Mucormycosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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