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MCID: MCR141
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Mucormycosis

Categories: Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mucormycosis

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MalaCards integrated aliases for Mucormycosis:

Name: Mucormycosis 12 74 52 58 3 15 17
Zygomycosis 12 74 52 58 3 32
Disseminated Mucormycosis 12 32

Characteristics:

Orphanet epidemiological data:

58
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases Oral diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8485
MESH via Orphanet 44 D009091 D020096
UMLS via Orphanet 72 C0026718 C0043541
Orphanet 58 ORPHA73263
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Summaries for Mucormycosis

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CDC : 3 Mucormycosis (sometimes called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These fungi live throughout the environment, particularly in soil and in decaying organic matter, such as leaves, compost piles, or rotten wood.1 People get mucormycosis by coming in contact with the fungal spores in the environment. For example, the lung or sinus forms of the infection can occur after someone breathes in spores. These forms of mucormycosis usually occur in people who have health problems or take medicines that lower the body's ability to fight germs and sickness.3,6 Mucormycosis can also develop on the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Mucormycosis, also known as zygomycosis, is related to aspergillosis and fusariosis. An important gene associated with Mucormycosis is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are MAPK signaling pathway and Hematopoietic cell lineage. The drugs Miconazole and Voriconazole have been mentioned in the context of this disorder. Affiliated tissues include sinuses, brain and lungs of immunocompromised people, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection located in sinuses, located in brain, or located in lungs of immunocompromised people, has material basis in Mucorales molds.

Wikipedia : 74 Mucormycosis is any fungal infection caused by fungi in the order Mucorales. Generally, species in the... more...

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Related Diseases for Mucormycosis

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Diseases related to Mucormycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 599)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.8 IFNG CSF3 CSF2 CLEC7A CCR6 CABIN1
2 fusariosis 30.6 CYP51A1 CSF3
3 panophthalmitis 30.4 IFNG CD4
4 pancytopenia 30.4 IFNG CSF3 CSF2 CD4
5 acquired immunodeficiency syndrome 30.4 IFNG CSF2 CD4 CCR6
6 gastroenteritis 30.4 IFNG CSF3 CSF2
7 candidiasis 30.2 IFNG CSF2 CLEC7A CARD9
8 bacterial infectious disease 30.2 IFNG CSF3 CSF2 CD4 CCR6
9 cerebritis 30.1 RHNO1 CD4
10 aplastic anemia 30.1 IFNG CYP3A4 CSF3 CSF2 CD4
11 chronic graft versus host disease 30.1 IFNG CD4
12 cryptococcosis 30.1 IFNG CSF2 CLEC7A CD4 CCR6
13 neuroretinitis 30.1 IFNG CD4
14 immune deficiency disease 30.1 IFNG CYP3A4 CSF2 CD4 CCR6
15 castleman disease 30.0 IFNG CSF3 CSF2
16 folliculitis 29.9 IFNG CD4 CCR6
17 lung abscess 29.9 IFNG FLNC CD4
18 histoplasmosis 29.9 IFNG CLEC7A CD4 CCR6
19 diarrhea 29.9 PPIG IFNG CYP3A4 CSF3
20 exanthem 29.9 CYP3A4 CSF3 CSF2 CD4 CCR6
21 common cold 29.9 FLNC CSF2 CD4 CCR6
22 bacterial pneumonia 29.8 CSF3 CD4 CCR6
23 temporal arteritis 29.8 IFNG CD4 CCR6
24 lymphadenitis 29.8 IFNG CD4 CCR6
25 ileus 29.8 INS IFNG CSF2
26 nocardiosis 29.8 CD4 CABIN1
27 myeloma, multiple 29.8 IFNG HSPA5 CSF3 CSF2 CD4 CCR6
28 meningoencephalitis 29.7 CD4 CCR6 CARD9
29 acute cystitis 29.7 INS CD4 CCR6
30 nervous system disease 29.7 IFNG CSF2 CD4 CCR6
31 leprosy 3 29.7 IFNG CSF2 CD4 CCR6
32 pulmonary disease, chronic obstructive 29.5 PPIG INS CSF2 CD4 CCR6
33 chromoblastomycosis 29.5 CLEC7A CCR6 CARD9
34 human immunodeficiency virus type 1 29.5 IFNG HSPA5 CYP3A4 CD4
35 paranasal sinus disease 29.4 RHNO1 IFNG FLNC CD4 CCR6
36 fungal meningitis 29.4 IFNG FLNC CYP51A1 CSF2 CD4
37 sporotrichosis 29.4 IFNG CLEC7A CD4 CARD9
38 phaeohyphomycosis 29.4 CLEC7A CARD9 B4GALNT2
39 conidiobolomycosis 29.3 PPIG CYP51A1 CYP3A4 B4GALNT2
40 peripheral nervous system disease 29.3 INS IFNG CSF3 CD4 CCR6
41 oral candidiasis 29.2 CLEC7A CD4 CCR6 CARD9
42 systemic lupus erythematosus 29.1 INS IFNG CYP2C19 CSF3 CSF2 CD4
43 pneumocystosis 29.1 FLNC CSF3 CLEC7A CD4 CCR6 CABIN1
44 invasive aspergillosis 29.0 IFNG FLNC CYP51A1 CYP2C19 CSF3 CLEC7A
45 subcutaneous mycosis 28.8 FLNC CLEC7A CCR6 CARD9 B4GALNT2
46 coccidioidomycosis 28.7 CYP51A1 CLEC7A CD4 CCR6 CARD9
47 malaria 28.6 INS IFNG CYP3A4 CSF3 CSF2 CD4
48 mycobacterium tuberculosis 1 28.4 PPIG IFNG CYP51A1 CYP3A4 CLEC7A CD4
49 opportunistic mycosis 27.6 RHNO1 IFNG FLNC CYP51A1 CSF3 CSF2
50 neutropenia 10.7

Graphical network of the top 20 diseases related to Mucormycosis:



Diseases related to Mucormycosis
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Symptoms & Phenotypes for Mucormycosis

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MGI Mouse Phenotypes related to Mucormycosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 B4GALNT2 CABIN1 CACNA1B CARD9 CCR6 CD4
2 digestive/alimentary MP:0005381 9.8 B4GALNT2 CD4 CLEC7A CYP51A1 HSPA5 IFNG
3 homeostasis/metabolism MP:0005376 9.77 B4GALNT2 CACNA1B CACNA1E CARD9 CCR6 CD4
4 immune system MP:0005387 9.4 B4GALNT2 CABIN1 CACNA1B CARD9 CCR6 CD4
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Drugs & Therapeutics for Mucormycosis

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Drugs for Mucormycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Voriconazole Approved Phase 4 137234-62-9 71616
3 Anti-Infective Agents Phase 4
4 Antifungal Agents Phase 4
5 Cytochrome P-450 CYP3A Inhibitors Phase 4
6 Cytochrome P-450 Enzyme Inhibitors Phase 4
7 Hormone Antagonists Phase 4
8 Steroid Synthesis Inhibitors Phase 4
9 Hormones Phase 4
10
Isavuconazole Approved, Investigational Phase 3 241479-67-4
11
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
12
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
13
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
14
Posaconazole Approved, Investigational, Vet_approved Phase 2 171228-49-2 147912
15 Anti-Bacterial Agents Phase 2
16 Chelating Agents Phase 2
17 Iron Chelating Agents Phase 2
18 Liposomal amphotericin B Phase 2
19 Antiparasitic Agents Phase 2
20 Antiprotozoal Agents Phase 2
21 Nutrients Phase 2
22 Trace Elements Phase 2
23 Micronutrients Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized Trial Comparing the Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing Completed NCT01416025 Phase 4 Prospective TDM Arm
2 A Phase 3, Multi-center, Open Label Study to Evaluate Safety and Efficacy of AK1820 for Treatment of Adult Japanese Patients With Deep Mycosis Recruiting NCT03471988 Phase 3 AK1820;Voriconazole
3 Treatment of Rhino-Sinusal Mucormycosis Through Transnasal Endoscopic Surgery Extended to the Skull Base. Unknown status NCT02226705 Phase 2
4 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
5 AMBIZYGO: Efficacy of High Dose [10 mg/kg/j] Liposomal Amphotericin B (Ambisome)Efficacy in Initial Zygomycosis Treatment:Phase II Trial Completed NCT00467883 Phase 2 Liposomal Amphotericin B
6 Phase II Study of Safety, Tolerance, Efficacy, and Pharmacokinetics of Posaconazole (SCH 56592) for the Treatment of Invasive Fungal Infections in Immunocompromised Hosts Completed NCT00034671 Phase 2 Posaconazole oral suspension
7 A Phase II Trial of the Safety and Efficacy of Iron Reduction by Phlebotomy in Recipients of Hematopoietic Stem Cell Transplants Completed NCT00689182 Phase 2
8 A Phase 2, Open-Label, Non-Comparative, Multicenter Study to Evaluate the Safety and Tolerability, Efficacy and Pharmacokinetics of Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Subjects Recruiting NCT03816176 Phase 2 Isavuconazonium sulfate;Isavuconazonium sulfate
9 Mucormycosis in ICU: A French Multicenter Cohort Study Unknown status NCT03387696
10 Systemic Fungal Infections in Intensive Care Unit Patients Unknown status NCT03292224
11 The Value of Real-Time Polymerase Chain Reaction (RT-PCR) Assay, Galactomannan and β-D-Glucan Detection (GM/G-Test) for Diagnosis of Invasive Fungal Infection (IFI) in Chinese Patients After Hematopoietic Stem Cell Transplantation (HSCT) Unknown status NCT00460330
12 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934
13 Multicenter Observational Study on Epidemiology, Treatment and Outcome of Mucormycosis in India Completed NCT03429023
14 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
15 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642

Search NIH Clinical Center for Mucormycosis

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Genetic Tests for Mucormycosis

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Anatomical Context for Mucormycosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Mucormycosis:

19
Sinuses, Brain, Lungs Of Immunocompromised People

MalaCards organs/tissues related to Mucormycosis:

40
Lung, Skin, Bone, Liver, Brain, Kidney, Myeloid
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Publications for Mucormycosis

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Articles related to Mucormycosis:

(show top 50) (show all 4098)
# Title Authors PMID Year
1
The cost-effectiveness of isavuconazole compared to the standard of care in the treatment of patients with invasive fungal infection prior to differential pathogen diagnosis in the United Kingdom. 61
31262225 2020
2
The reversed halo sign and mucormycosis. 61
31782402 2019
3
Mucormycosis: an unusual masquerader of an endobronchial tumour. 61
31576206 2019
4
Gastrointestinal bleeding due to duodenal mucormycosis in an immunocompetent host mimicking malignancy. 61
31617363 2019
5
From the Pharynx to the Brain: A Case of Rapidly Progressing Mucormycosis. 61
31655951 2019
6
A multicenter observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India. 61
31811914 2019
7
Serial Detection of Circulating Mucorales DNA in Invasive Mucormycosis: A Retrospective Multicenter Evaluation. 61
31816976 2019
8
Gastrointestinal Mucormycosis in a two-year-old child: A clinical and radiological enigma. 61
31667050 2019
9
Cutaneous mucormycosis by Rhizopus arrhizus treated with isavuconazole as first line therapy: A case report. 61
31667060 2019
10
Control of an outbreak of post-transplant cutaneous mucormycosis by removing the vehicle: An intervention study of contiguous cohorts. 61
31812269 2019
11
Disseminated Gastrointestinal Basidiobolomycosis (GIB) in an infant from Western India. 61
31667059 2019
12
Orbital mycoses in an adult subtropical population. 61
31822858 2019
13
Combination of amphotericin B and caspofungin in the treatment of mucormycosis. 61
31667058 2019
14
Sporulation on blood serum increases the virulence of Mucor circinelloides. 61
31513895 2019
15
Surgical-site mucormycosis infection in a solid-organ transplant recipient and a concise review of the literature. 61
31826901 2019
16
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. 61
31699664 2019
17
Invasive fungal wound infection in an otherwise healthy trauma patient (Mucor Trauma). 61
31788530 2019
18
Case report of penile Rhizopus arrhizus infection in an unexpected patient. 61
31667053 2019
19
Fabrication of a bicomponent hybrid orbital prosthesis. 61
31227245 2019
20
A Retrospective Analysis of Invasive Fungal Diseases (IFD) of the Central Nervous System in Children With Lymphoid Malignancies. 61
31815886 2019
21
Clinical spectrum and outcome of hospitalized patients with invasive fungal infections: a prospective study from a medical ward/intensive care unit of a teaching hospital in North India. 61
31846989 2019
22
Mucormycosis with peculiar aortic involvement in a child with acute lymphoblastic leukemia. 61
31847684 2019
23
Use of Antifungals and Outcomes Among Inpatients at Risk of Invasive Aspergillosis or Mucormycosis in the USA: A Retrospective Cohort Study. 61
31598932 2019
24
Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn). 61
31393591 2019
25
The elusive nature of mucormycosis in an immunocompetent host and the role of a dermatology consult. 61
31788276 2019
26
Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus. 61
31407820 2019
27
Overview and outcome of mucormycosis among children with cancer: Report from the Children's Cancer Hospital Egypt. 61
30983046 2019
28
Rhino-orbito-cerebral mucormycosis following penetrating keratoplasty. 61
31832132 2019
29
Molecular Diagnostics of Mucormycosis in Hematological Patients: A Literature Review. 61
31795369 2019
30
Gastric mucormycosis complicated by a gastropleural fistula: A case report and review of the literature. 61
31770250 2019
31
Sinonasal Mucormycosis: A to Z. 61
31763277 2019
32
A modified technique to fabricate a complete hollow obturator for bilateral maxillectomy in a patient with mucormycosis-A technical case report. 61
31608482 2019
33
Antagonistic Interaction of Staphylococcus aureus and Staphylococcus epidermidis with Rhizopus arrhizus Mediated by Phenol Soluble Modulins and Organic Acids. 61
31535547 2019
34
Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. 61
31690679 2019
35
Updates on the Taxonomy of Mucorales with an Emphasis on Clinically Important Taxa. 61
31739583 2019
36
Comparative in vitro pharmacodynamic analysis of isavuconazole, voriconazole, and posaconazole against clinical isolates of aspergillosis, mucormycosis, fusariosis, and phaeohyphomycosis. 61
31427139 2019
37
Diagnostic performance of immunohistochemistry for the aspergillosis and mucormycosis. 61
31444927 2019
38
Comparison of Clinical Manifestation, Diagnosis, and Outcomes of Invasive Pulmonary Aspergillosis and Pulmonary Mucormycosis. 61
31694308 2019
39
Concomitant cerebral aspergillosis and mucormycosis in an immunocompetent woman treated with corticosteroids. 61
31713052 2019
40
Invasive Pulmonary Aspergillosis Due to Aspergillus awamori: Role of Calcium Oxalate Crystal Precipitation Mimicking Mucormycosis. 61
31741128 2019
41
A population-based analysis of attributable hospitalisation costs of invasive fungal diseases in haematological malignancy patients using data linkage of state-wide registry and costing databases: 2009-2015. 61
31715052 2019
42
Surgical resection for persistent localized pulmonary fungal infection prior to allogeneic hematopoietic stem cell transplantation: Analysis of six cases. 61
31735628 2019
43
Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. 61
31656543 2019
44
Facial Nerve Palsy: An Unusual Presentation in Patients with Rhino Cerebral Mucormycosis. 61
31763303 2019
45
Mucormycosis experience through the eyes of the laboratory. 61
31364897 2019
46
A Fatal Case of Disseminated Mucormycosis Mimicking a Malignancy. 61
31606811 2019
47
Maxillary mucormycosis causing oroantral fistula in a young female. 61
31823958 2019
48
Management of bilateral rhino-orbital cerebral mucormycosis. 61
31761754 2019
49
The use of genome sequencing to investigate an outbreak of hospital-acquired mucormycosis in transplant patients. 61
31472083 2019
50
Outcomes and factors affecting them in patients with rhino-orbito-cerebral mucormycosis. 61
30514712 2019
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Variations for Mucormycosis

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Expression for Mucormycosis

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Search GEO for disease gene expression data for Mucormycosis.
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Pathways for Mucormycosis

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Pathways related to Mucormycosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MAPK signaling pathway 1 36
12.22 INS HSPA5 FLNC CACNA1E CACNA1B
2
Hematopoietic cell lineage 36
11.65 CSF3 CSF2 CD4
3
Type II diabetes mellitus 36 1
Show member pathways
 11.62 INS CACNA1E CACNA1B
4
Salmonella infection (KEGG) 36
11.48 IFNG FLNC CSF2
5
Innate Lymphoid Cell Differentiation Pathways 64
11.45 IFNG CD4 CCR6
6
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.38 IFNG CSF2 CABIN1
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.32 IFNG CSF3 CSF2 CD4
8
Dendritic Cells Developmental Lineage Pathway 64
11.3 IFNG CSF2 CD4
9
Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) 60
10.51 CACNA1E CACNA1B
10
Cytokines and Inflammatory Response 1
10.39 IFNG CSF3 CSF2 CD4
Sources

GO Terms for Mucormycosis

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Cellular components related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 9.13 CYP51A1 CYP3A4 CYP2C19
2 intracellular membrane-bounded organelle GO:0043231 9.1 HSPA5 CYP51A1 CYP3A4 CYP2C19 CSF2 CLEC7A

Biological processes related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 INS IFNG CSF3 CSF2 CLEC7A
2 immune response GO:0006955 9.83 IFNG CSF3 CSF2 CD4 CCR6
3 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.48 CLEC7A CD4
4 negative regulation of amyloid-beta clearance GO:1900222 9.4 IFNG CYP51A1
5 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.37 CSF2 CD4
6 positive regulation of respiratory burst GO:0060267 9.32 INS CLEC7A
7 heterocycle metabolic process GO:0046483 9.26 CYP3A4 CYP2C19
8 positive regulation of killing of cells of other organism GO:0051712 9.16 IFNG CLEC7A
9 monoterpenoid metabolic process GO:0016098 8.96 CYP3A4 CYP2C19
10 positive regulation of interleukin-23 production GO:0032747 8.62 IFNG CSF2

Molecular functions related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP51A1 CYP3A4 CYP2C19
2 enzyme binding GO:0019899 9.02 HSPA5 CYP3A4 CYP2C19 CSF3 CD4
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Sources for Mucormycosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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