MCID: MCR141
MIFTS: 49

Mucormycosis

Categories: Immune diseases, Infectious diseases, Oral diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Mucormycosis

MalaCards integrated aliases for Mucormycosis:

Name: Mucormycosis 12 76 59 3 15
Zygomycosis 12 76 53 59 3
Disseminated Mucormycosis 12

Characteristics:

Orphanet epidemiological data:

59
zygomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:8485
Orphanet 59 ORPHA73263
MESH via Orphanet 45 D009091 D020096
UMLS via Orphanet 74 C0026718 C0043541

Summaries for Mucormycosis

CDC : 3 Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people with weakened immune systems and can occur in nearly any part of the body. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air, or the skin after the fungus enters the skin through a cut, scrape, burn, or other type of skin trauma.

MalaCards based summary : Mucormycosis, also known as zygomycosis, is related to aspergillosis and carotid artery thrombosis. An important gene associated with Mucormycosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Amoebiasis. The drugs Posaconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain, and related phenotype is renal/urinary system.

Disease Ontology : 12 An opportunistic mycosis that results in fungal infection located in sinuses, located in brain, or located in lungs of immunocompromised people, has material basis in Mucorales molds.

Wikipedia : 76 Mucormycosis is any fungal infection caused by fungi in the order Mucorales. Generally, species in the... more...

Related Diseases for Mucormycosis

Diseases related to Mucormycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.7 CSF2 IFNG
2 carotid artery thrombosis 29.8 CSF2 IFNG
3 acquired immunodeficiency syndrome 29.7 CSF2 IFNG
4 chronic granulomatous disease 29.6 CSF2 IFNG
5 leukemia 10.4
6 lymphocytic leukemia 10.3
7 diabetes mellitus 10.2
8 thrombosis 10.2
9 leukemia, acute lymphoblastic 10.2
10 leukemia, acute myeloid 10.1
11 invasive aspergillosis 10.1
12 lymphoma 10.1
13 myeloid leukemia 10.1
14 large granular lymphocyte leukemia 10.1 CSF2 IFNG
15 trichosporonosis 10.1 CSF2 IFNG
16 candida glabrata 10.1 CSF2 IFNG
17 human t-cell leukemia virus type 2 10.1 CSF2 IFNG
18 meconium aspiration syndrome 10.1 CSF2 IFNG
19 hypersplenism 10.1 CSF2 IFNG
20 cytomegalovirus retinitis 10.1 CSF2 IFNG
21 cryptococcal meningitis 10.1 CSF2 IFNG
22 smallpox 10.1 CSF2 IFNG
23 langerhans cell histiocytosis 10.1 CSF2 IFNG
24 pulmonary sarcoidosis 10.1 CSF2 IFNG
25 systemic lupus erythematosus 10.1
26 paranasal sinus disease 10.1 IFNG RHNO1
27 opportunistic mycosis 10.1 IFNG RHNO1
28 monocytic leukemia 10.1 CSF2 IFNG
29 ethmoid sinusitis 10.1 CSF2 RHNO1
30 upper respiratory tract disease 10.0 IFNG RHNO1
31 diabetes mellitus, ketosis-prone 10.0
32 acute lymphocytic leukemia 10.0
33 osteomyelitis 10.0
34 lupus erythematosus 10.0
35 respiratory system disease 10.0 CSF2 IFNG
36 liver cirrhosis 10.0
37 sarcoidosis 1 10.0 CSF2 IFNG
38 bacterial infectious disease 10.0 CSF2 IFNG
39 candidiasis 10.0
40 cavernous sinus thrombosis 10.0
41 pneumonia 10.0
42 carotid artery occlusion 10.0
43 leukemia, chronic lymphocytic 2 9.9
44 leukemia, chronic lymphocytic 9.9
45 enterocolitis 9.9
46 acute leukemia 9.9
47 neutropenia 9.9
48 pulmonary tuberculosis 9.9
49 perinatal necrotizing enterocolitis 9.9
50 leukemia, b-cell, chronic 9.9

Graphical network of the top 20 diseases related to Mucormycosis:



Diseases related to Mucormycosis

Symptoms & Phenotypes for Mucormycosis

MGI Mouse Phenotypes related to Mucormycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 CSF2 HSPA5 IFNG TREH

Drugs & Therapeutics for Mucormycosis

Drugs for Mucormycosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 171228-49-2 147912
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
3 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
4 Hormones Phase 4,Phase 3,Phase 2
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2
6 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
7 Antiparasitic Agents Phase 4,Phase 3,Phase 2
8 Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Antifungal Agents Phase 4,Phase 3,Phase 2
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
12
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
13 Pharmaceutical Solutions Phase 3
14 Cytochrome P-450 CYP3A Inhibitors Phase 3
15
Deferasirox Approved, Investigational Phase 2 201530-41-8 5493381
16
Iron Approved Phase 2 7439-89-6 23925
17
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
18 Chelating Agents Phase 2
19 Iron Chelating Agents Phase 2
20 Anti-Bacterial Agents Phase 2
21 Liposomal amphotericin B Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
2 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
3 Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis Recruiting NCT03471988 Phase 3 AK1820;Voriconazole
4 Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis Unknown status NCT02226705 Phase 2
5 The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study Completed NCT00419770 Phase 2 deferasirox;Placebo;Liposomal amphotericin B
6 Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment Completed NCT00467883 Phase 2 Liposomal Amphotericin B
7 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
8 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
9 A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants Not yet recruiting NCT03816176 Phase 2 Isavuconazonium sulfate
10 Prospective Evaluation of a New Molecular Tool for Early Diagnosis of Mucormycosis Completed NCT02845934 Not Applicable
11 Descriptive Epidemiology on Management of Mucormycosis Completed NCT03429023
12 Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis Completed NCT00923832
13 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
14 Mucormycosis in ICU Recruiting NCT03387696
15 Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis Not yet recruiting NCT03569904

Search NIH Clinical Center for Mucormycosis

Genetic Tests for Mucormycosis

Anatomical Context for Mucormycosis

MalaCards organs/tissues related to Mucormycosis:

41
Lung, Skin, Brain, Liver, Kidney, Myeloid, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Mucormycosis:

19
Brain, Sinuses, Lungs Of Immunocompromised People

Publications for Mucormycosis

Articles related to Mucormycosis:

(show top 50) (show all 1129)
# Title Authors Year
1
Treatment of cerebral mucormycosis with drug therapy alone: A case report. ( 30425919 )
2019
2
Cutaneous Mucormycosis Following a Bullous Pemphigoid Flare in a Chronic Lymphocytic Leukemia Patient on Ibrutinib. ( 29760835 )
2018
3
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy. ( 29750016 )
2018
4
How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients. ( 29975240 )
2018
5
Management of Recurrent Rhinomaxillary Mucormycosis and Nasal Myiasis in an Uncontrolled Diabetic Patient: A Systematic Approach. ( 29744327 )
2018
6
Mucormycosis Osteomyelitis of the Hand. ( 29934077 )
2018
7
Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with Adult Onset Still's Disease. ( 30148059 )
2018
8
Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient. ( 29188178 )
2018
9
Invasive pulmonary mucormycosis and aspergillosis in a patient with decompensated hepatic cirrhosis. ( 29560305 )
2018
10
Primary Cutaneous Mucormycosis in a Beta-Thalassemia Patient. ( 30369766 )
2018
11
Orbitocerebral Mucormycosis in a Patient With Central Nervous System Lymphoma. ( 30320719 )
2018
12
Pulmonary mucormycosis in an adolescent female with type 1 diabetes mellitus. ( 30524955 )
2018
13
Successful Treatment of Concurrent Mucormycosis and Diffuse Alveolar Hemorrhage in a Patient With Newly Diagnosed Systemic Lupus Erythematosus. ( 30207572 )
2018
14
Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient. ( 30192700 )
2018
15
An Interesting Case of a 57-Year-Old Male with an Upper Gastrointestinal Bleeding and Obstructive Uropathy with Bilateral Hydronephrosis Diagnosed with Systemic Mucormycosis. ( 30026991 )
2018
16
Invasive rhinocerebral mucormycosis in a patient with liver cirrhosis leading to fatal massive stroke. ( 30294535 )
2018
17
Cutaneous mucormycosis caused by Saksenaea vasiformis in a patient with systemic lupus erythematosus. ( 30214752 )
2018
18
Pulmonary Mucormycosis in Chronic Lymphocytic Leukemia and Neutropenia. ( 29670779 )
2018
19
Rhinoorbitocerebral Mucormycosis with Maggots in a Neglected Diabetic Patient. ( 29456961 )
2018
20
Invasive Cutaneous Facial Mucormycosis in a Trauma Patient. ( 29458027 )
2018
21
Pulmonary Mucormycosis: Radiologic Features at Presentation and Over Time. ( 29470162 )
2018
22
In Situ Validation of the Endothelial Cell Receptor GRP78 in a Case of Rhinocerebral Mucormycosis. ( 29483124 )
2018
23
Mucormycosis in immunocompetent patient resulting in extensive maxillary sequestration. ( 29491619 )
2018
24
Challenges in the diagnosis and treatment of mucormycosis. ( 29538730 )
2018
25
Mucormycosis in Iran: A six-year retrospective experience. ( 29545123 )
2018
26
Mucormycosis: Early Identification of a Deadly Fungus [Formula: see text]. ( 29560764 )
2018
27
Invasive cutaneous mucormycosis in a preterm neonate presenting as a vesicobullous lesion. ( 29567895 )
2018
28
Isolated cutaneous mucormycosis in a pediatric renal transplant recipient. ( 29569805 )
2018
29
Invasive Gastrointestinal Mucormycosis: A Master Masquerader. ( 29570587 )
2018
30
Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature. ( 29573830 )
2018
31
Comparative genome-wide analysis of extracellular small RNAs from the mucormycosis pathogen Rhizopus delemar. ( 29588481 )
2018
32
Successful Conservative Management of Bilateral Renal Mucormycosis. ( 29601838 )
2018
33
Successful Use of a Double Lumen Endotracheal Tube and Bronchial Blocker for Lung Isolation in Pulmonary Mucormycosis. ( 29631944 )
2018
34
Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India. ( 29642408 )
2018
35
Endobronchial Mucormycosis Successfully Treated with Flexible Bronchoscopic Cryotherapy. ( 29648882 )
2018
36
Cutaneous mucormycosis as a presenting feature of type 1 diabetes in a boy - case report and review of the literature. ( 29672274 )
2018
37
Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. ( 29691339 )
2018
38
Urokinase application for hemothorax in pulmonary mucormycosis. ( 29707367 )
2018
39
Development of a quantitative PCR detecting Cunninghamella bertholletiae to help in diagnosing this rare and aggressive mucormycosis. ( 29712993 )
2018
40
Mucormycosis of maxilla following tooth extraction in immunocompetent patients: Reports and review. ( 29721234 )
2018
41
Total Gastric Necrosis Due to Mucormycosis: A Rare Case of Gastric Perforation. ( 29724988 )
2018
42
Characteristics of pulmonary mucormycosis and predictive risk factors for the outcome. ( 29748841 )
2018
43
Non-sinonasal isolated facio-orbital mucormycosis - A case report. ( 29773436 )
2018
44
Ruptured Mycotic Aneurysm of the Distal Circulation in a Patient with Mucormycosis Without Direct Skull Base Extension: Case Report. ( 29800469 )
2018
45
On the Nose: Disseminated Mucormycosis. ( 29806997 )
2018
46
Thoracoabdominal Resection of Mucormycosis Lesions in a Leukemic Patient. ( 29807006 )
2018
47
Voriconazole associated mucormycosis in a patient with relapsed acute lymphoblastic leukemia and hematopoietic stem cell transplant failure: A case report. ( 29807852 )
2018
48
Neonatal Mucormycosis with Gastrointestinal and Cutaneous involvement. ( 29845959 )
2018
49
Self-resolving superficial primary cutaneous mucormycosis in a 7-week-old infant. ( 29846009 )
2018
50
Gastrointestinal mucormycosis in apparently immunocompetent hosts-A review. ( 29855116 )
2018

Variations for Mucormycosis

Expression for Mucormycosis

Search GEO for disease gene expression data for Mucormycosis.

Pathways for Mucormycosis

GO Terms for Mucormycosis

Biological processes related to Mucormycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.96 CSF2 IFNG
2 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Mucormycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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