Mueller-Weiss Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Mueller-Weiss Syndrome

MalaCards integrated aliases for Mueller-Weiss Syndrome:

Name: Mueller-Weiss Syndrome ⁵⁸ ⁷⁵

Mueller-Weiss Osteonecrosis of the Tarsal Bone ⁵⁸

Brailsford Disease ⁵⁸

Characteristics:

Age Of Onset:

Adult ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare systemic and rhumatological diseases

Rare bone diseases

External Ids:

Orphanet ⁵⁸ ORPHA566943

SNOMED-CT via HPO ⁶⁹ 203534009 228158008 239873007 more

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Summaries for Mueller-Weiss Syndrome

Orphanet: ⁵⁸ A rare bone disease characterized by spontaneous adult-onset tarsal navicular osteonecrosis. Patients present with chronic mid- and hindfoot pain, swelling and tenderness over the dorsomedial aspect of the midfoot, flattening of the medial longitudinal arch, and pes planovarus. Radiographic findings include comma-shaped deformity due to collapse of the lateral part of the navicular bone and medial or dorsal protrusion of a portion or the entire bone. The condition may be bilateral or asymmetric and associated with pathological fractures.

MalaCards based summary: Mueller-Weiss Syndrome, also known as mueller-weiss osteonecrosis of the tarsal bone, is related to mucopolysaccharidosis iv and osteonecrosis. Affiliated tissues include bone, and related phenotypes are foot pain and avascular necrosis

Wikipedia: ⁷⁵ Mueller-Weiss syndrome, also known as Mueller-Weiss disease, is a rare idiopathic degenerative disease... more...

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Related Diseases for Mueller-Weiss Syndrome

Diseases related to Mueller-Weiss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	mucopolysaccharidosis iv	11.3
2	osteonecrosis	10.5
3	achondroplasia	9.9
4	mucopolysaccharidosis-plus syndrome	9.9
5	osteochondrodysplasia	9.9

Graphical network of the top 20 diseases related to Mueller-Weiss Syndrome:

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Symptoms & Phenotypes for Mueller-Weiss Syndrome

Human phenotypes related to Mueller-Weiss Syndrome:

⁵⁸ ³⁰ (show all 21)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	foot pain ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0025238
2	avascular necrosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010885
3	joint stiffness ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001387
4	difficulty walking ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002355
5	chondritis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100662
6	edema of the dorsum of feet ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012098
7	sclerosis of foot bone ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100925
8	limitation of movement at ankles ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010505
9	facet joint arthrosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030871
10	abnormality of the os naviculare pedis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100339
11	pes planus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001763
12	tibial torsion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100694
13	joint subluxation ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0032153
14	talipes calcaneovarus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0008124
15	equinovarus deformity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0008110
16	knee osteoarthritis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005086
17	fragmented, irregular epiphyses ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005063
18	tibiofibular diastasis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100535
19	arthritis ⁵⁸		Occasional (29-5%)
20	pedal edema ⁵⁸		Frequent (79-30%)
21	positional foot deformity ⁵⁸		Frequent (79-30%)

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Drugs & Therapeutics for Mueller-Weiss Syndrome

Search Clinical Trials, NIH Clinical Center for Mueller-Weiss Syndrome

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Genetic Tests for Mueller-Weiss Syndrome

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Anatomical Context for Mueller-Weiss Syndrome

Organs/tissues related to Mueller-Weiss Syndrome:

MalaCards : Bone

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Publications for Mueller-Weiss Syndrome

Articles related to Mueller-Weiss Syndrome:

(show all 26)

#	Title	Authors	PMID	Year
1	Problems in Instrumentation of Syndromic Craniovertebral Junction Anomalies - Case Reports. ⁶²	Muthukumar N	31261467	2019
2	Spontaneous Osteonecrosis of the Tarsal Navicular: A Report of Two Cases. ⁶²	Kitaura Y...Sudo A	30838149	2019
3	Imaging of Mueller-Weiss Syndrome: A Review of Clinical Presentations and Imaging Spectrum. ⁶²	Samim M...Smitaman E	27145453	2016
4	Mueller-Weiss syndrome: imaging and implications. ⁶²	Bartolotta RJ...Hentel KD	25064253	2014
5	Treatment of Spontaneous Osteonecrosis of the Tarsal Navicular With a Free Medial Femoral Condyle Vascularized Bone Graft: A New Approach to Managing a Difficult Problem. ⁶²	Levinson H...Parekh SG	24368773	2014
6	Mueller Weiss syndrome--case report. ⁶²	Marchi SE...Fernandes Ede A	24918995	2014
7	Diagnostic imaging of the mueller-weiss syndrome: findings of a rare condition of the foot. ⁶²	Nguyen AS...Mote GA	24504587	2014
8	Percutaneous decompression for the treatment of Mueller-Weiss syndrome. ⁶²	Janositz G...Toth K	21063683	2011
9	Spontaneous osteonecrosis of the tarsal navicular in an adult: Mueller-Weiss syndrome. ⁶²	Tosun B...Tosun A	21354008	2011
10	Bilateral total hip arthroplasty in Morquio-Brailsford's syndrome: a report of two cases. ⁶²	Tassinari E...Giunti A	18488165	2008
11	Answer to case of the month #129. Mueller-Weiss syndrome. ⁶²	Venu V...Forster BB	18386757	2008
12	Mueller-Weiss syndrome: an uncommon cause of midfoot pain. ⁶²	Reade B...Kruljac S	9879050	1998
13	Osteochondrosis of the tarsal navicular in a female high school distance runner. ⁶²	Palamarchuk HJ...Aronson SM	7738822	1995
14	Chondro-osteodystrophy (Morquio Brailsford disease, mucopolysaccharidosis type IV A). ⁶²	Roche S...Fielding JF	1473953	1992
15	De La Caffinière replacement arthroplasty in Morquio-Brailsford disease. ⁶²	Blude EA...Reiff DB	2123626	1990
16	[Morquio-Brailsford disease in a refugee from Vietnam. Orthopedic and social arrangements]. ⁶²	Feilberg V...Hejgaard N	3109091	1987
17	[Medullary compression in Morquio-Brailsford disease]. ⁶²	Strange P...Ostergaard JR	6794203	1981
18	Morquio-Brailsford disease. A report of four affected sisters with absence of excessive keratan sulphate in the urine. ⁶²	Jenkins P...Harper PS	4199240	1973
19	Some aspects of respiratory function in three siblings with Morquio-Brailsford disease. ⁶²	Hope EO...Bainbridge D	4198955	1973
20	[Morquio-Brailsford disease]. ⁶²	Pagani A	4245223	1970
21	Radiological case of the month. Morquio-Brailsford disease. ⁶²	Gwinn JL...Barnes GR	4966595	1968
22	[ON CLINICAL ASPECTS OF THE MORQUIO-BRAILSFORD DISEASE]. ⁶²	BOEHME A	14268250	1965
23	[SIMILARITY AND DIFFERENCE OF FAMILIAL OSTEOCHONDRODYSPLASIA OR MORQUIO'S DISEASE AND OSTEOCHONDRODYSTROPHY OR BRAILSFORD DISEASE]. ⁶²	ARCE F...ARCE M	14131802	1964
24	[On Morquio-Brailsford disease]. ⁶²	VACHTENHEIM J...NOVAK D	13924099	1962
25	[Mueller-Weiss-Brailsford disease]. ⁶²	ROCA CA...RAMOS VERTIZ JR	14438025	1959
26	Osteo-chondrodystrophia deformans (Morquio Brailsford disease). ⁶²	FELDMAN N...DAVENPORT ME	14878464	1951

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Genes for Mueller-Weiss Syndrome

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Variations for Mueller-Weiss Syndrome

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Expression for Mueller-Weiss Syndrome

Search GEO for disease gene expression data for Mueller-Weiss Syndrome.

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Pathways for Mueller-Weiss Syndrome

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GO Terms for Mueller-Weiss Syndrome

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Sources for Mueller-Weiss Syndrome

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⁷³ UniProtKB/Swiss-Prot

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⁷⁵ Wikipedia

MCID: MLL024 MIFTS: 21	Mueller-Weiss Syndrome Categories: Bone diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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