MCID: MLL024
MIFTS: 21

Mueller-Weiss Syndrome

Categories: Bone diseases, Rare diseases
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Aliases & Classifications for Mueller-Weiss Syndrome

MalaCards integrated aliases for Mueller-Weiss Syndrome:

Name: Mueller-Weiss Syndrome 58 75
Mueller-Weiss Osteonecrosis of the Tarsal Bone 58
Brailsford Disease 58

Characteristics:


Age Of Onset:

Adult 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


Summaries for Mueller-Weiss Syndrome

Orphanet: 58 A rare bone disease characterized by spontaneous adult-onset tarsal navicular osteonecrosis. Patients present with chronic mid- and hindfoot pain, swelling and tenderness over the dorsomedial aspect of the midfoot, flattening of the medial longitudinal arch, and pes planovarus. Radiographic findings include comma-shaped deformity due to collapse of the lateral part of the navicular bone and medial or dorsal protrusion of a portion or the entire bone. The condition may be bilateral or asymmetric and associated with pathological fractures.

MalaCards based summary: Mueller-Weiss Syndrome, also known as mueller-weiss osteonecrosis of the tarsal bone, is related to mucopolysaccharidosis iv and osteonecrosis. Affiliated tissues include bone, and related phenotypes are foot pain and avascular necrosis

Wikipedia: 75 Mueller-Weiss syndrome, also known as Mueller-Weiss disease, is a rare idiopathic degenerative disease... more...

Related Diseases for Mueller-Weiss Syndrome

Diseases related to Mueller-Weiss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mucopolysaccharidosis iv 11.3
2 osteonecrosis 10.5
3 achondroplasia 9.9
4 mucopolysaccharidosis-plus syndrome 9.9
5 osteochondrodysplasia 9.9

Graphical network of the top 20 diseases related to Mueller-Weiss Syndrome:



Diseases related to Mueller-Weiss Syndrome

Symptoms & Phenotypes for Mueller-Weiss Syndrome

Human phenotypes related to Mueller-Weiss Syndrome:

58 30 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 foot pain 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0025238
2 avascular necrosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0010885
3 joint stiffness 58 30 Frequent (33%) Frequent (79-30%)
HP:0001387
4 difficulty walking 58 30 Frequent (33%) Frequent (79-30%)
HP:0002355
5 chondritis 58 30 Frequent (33%) Frequent (79-30%)
HP:0100662
6 edema of the dorsum of feet 58 30 Frequent (33%) Frequent (79-30%)
HP:0012098
7 sclerosis of foot bone 58 30 Frequent (33%) Frequent (79-30%)
HP:0100925
8 limitation of movement at ankles 58 30 Frequent (33%) Frequent (79-30%)
HP:0010505
9 facet joint arthrosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0030871
10 abnormality of the os naviculare pedis 58 30 Frequent (33%) Frequent (79-30%)
HP:0100339
11 pes planus 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001763
12 tibial torsion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100694
13 joint subluxation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0032153
14 talipes calcaneovarus 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0008124
15 equinovarus deformity 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0008110
16 knee osteoarthritis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005086
17 fragmented, irregular epiphyses 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005063
18 tibiofibular diastasis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100535
19 arthritis 58 Occasional (29-5%)
20 pedal edema 58 Frequent (79-30%)
21 positional foot deformity 58 Frequent (79-30%)

Drugs & Therapeutics for Mueller-Weiss Syndrome

Search Clinical Trials, NIH Clinical Center for Mueller-Weiss Syndrome

Genetic Tests for Mueller-Weiss Syndrome

Anatomical Context for Mueller-Weiss Syndrome

Organs/tissues related to Mueller-Weiss Syndrome:

MalaCards : Bone

Publications for Mueller-Weiss Syndrome

Articles related to Mueller-Weiss Syndrome:

(show all 26)
# Title Authors PMID Year
1
Problems in Instrumentation of Syndromic Craniovertebral Junction Anomalies - Case Reports. 62
31261467 2019
2
Spontaneous Osteonecrosis of the Tarsal Navicular: A Report of Two Cases. 62
30838149 2019
3
Imaging of Mueller-Weiss Syndrome: A Review of Clinical Presentations and Imaging Spectrum. 62
27145453 2016
4
Mueller-Weiss syndrome: imaging and implications. 62
25064253 2014
5
Treatment of Spontaneous Osteonecrosis of the Tarsal Navicular With a Free Medial Femoral Condyle Vascularized Bone Graft: A New Approach to Managing a Difficult Problem. 62
24368773 2014
6
Mueller Weiss syndrome--case report. 62
24918995 2014
7
Diagnostic imaging of the mueller-weiss syndrome: findings of a rare condition of the foot. 62
24504587 2014
8
Percutaneous decompression for the treatment of Mueller-Weiss syndrome. 62
21063683 2011
9
Spontaneous osteonecrosis of the tarsal navicular in an adult: Mueller-Weiss syndrome. 62
21354008 2011
10
Bilateral total hip arthroplasty in Morquio-Brailsford's syndrome: a report of two cases. 62
18488165 2008
11
Answer to case of the month #129. Mueller-Weiss syndrome. 62
18386757 2008
12
Mueller-Weiss syndrome: an uncommon cause of midfoot pain. 62
9879050 1998
13
Osteochondrosis of the tarsal navicular in a female high school distance runner. 62
7738822 1995
14
Chondro-osteodystrophy (Morquio Brailsford disease, mucopolysaccharidosis type IV A). 62
1473953 1992
15
De La Caffinière replacement arthroplasty in Morquio-Brailsford disease. 62
2123626 1990
16
[Morquio-Brailsford disease in a refugee from Vietnam. Orthopedic and social arrangements]. 62
3109091 1987
17
[Medullary compression in Morquio-Brailsford disease]. 62
6794203 1981
18
Morquio-Brailsford disease. A report of four affected sisters with absence of excessive keratan sulphate in the urine. 62
4199240 1973
19
Some aspects of respiratory function in three siblings with Morquio-Brailsford disease. 62
4198955 1973
20
[Morquio-Brailsford disease]. 62
4245223 1970
21
Radiological case of the month. Morquio-Brailsford disease. 62
4966595 1968
22
[ON CLINICAL ASPECTS OF THE MORQUIO-BRAILSFORD DISEASE]. 62
14268250 1965
23
[SIMILARITY AND DIFFERENCE OF FAMILIAL OSTEOCHONDRODYSPLASIA OR MORQUIO'S DISEASE AND OSTEOCHONDRODYSTROPHY OR BRAILSFORD DISEASE]. 62
14131802 1964
24
[On Morquio-Brailsford disease]. 62
13924099 1962
25
[Mueller-Weiss-Brailsford disease]. 62
14438025 1959
26
Osteo-chondrodystrophia deformans (Morquio Brailsford disease). 62
14878464 1951

Variations for Mueller-Weiss Syndrome

Expression for Mueller-Weiss Syndrome

Search GEO for disease gene expression data for Mueller-Weiss Syndrome.

Pathways for Mueller-Weiss Syndrome

GO Terms for Mueller-Weiss Syndrome

Sources for Mueller-Weiss Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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