MCID: MLT005
MIFTS: 16

Multicentric Papillary Thyroid Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Multicentric Papillary Thyroid Carcinoma

MalaCards integrated aliases for Multicentric Papillary Thyroid Carcinoma:

Name: Multicentric Papillary Thyroid Carcinoma 12 15
Multicentric Thyroid Gland Papillary Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7086
NCIt 50 C37304
UMLS 73 C1334817

Summaries for Multicentric Papillary Thyroid Carcinoma

MalaCards based summary : Multicentric Papillary Thyroid Carcinoma, also known as multicentric thyroid gland papillary carcinoma, is related to thyroid cancer, nonmedullary, 1 and thyroiditis. An important gene associated with Multicentric Papillary Thyroid Carcinoma is PNLIP (Pancreatic Lipase). Affiliated tissues include thyroid and pituitary.

Related Diseases for Multicentric Papillary Thyroid Carcinoma

Diseases related to Multicentric Papillary Thyroid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 thyroid cancer, nonmedullary, 1 10.0
2 thyroiditis 10.0
3 paraganglioma 9.8
4 gastric leiomyoma 9.8
5 leiomyoma 9.8
6 pituitary adenoma 9.8
7 adenoma 9.8
8 amyloidosis 9.8
9 multiple endocrine neoplasia 9.8

Graphical network of the top 20 diseases related to Multicentric Papillary Thyroid Carcinoma:



Diseases related to Multicentric Papillary Thyroid Carcinoma

Symptoms & Phenotypes for Multicentric Papillary Thyroid Carcinoma

Drugs & Therapeutics for Multicentric Papillary Thyroid Carcinoma

Search Clinical Trials , NIH Clinical Center for Multicentric Papillary Thyroid Carcinoma

Genetic Tests for Multicentric Papillary Thyroid Carcinoma

Anatomical Context for Multicentric Papillary Thyroid Carcinoma

MalaCards organs/tissues related to Multicentric Papillary Thyroid Carcinoma:

41
Thyroid, Pituitary

Publications for Multicentric Papillary Thyroid Carcinoma

Articles related to Multicentric Papillary Thyroid Carcinoma:

# Title Authors Year
1
High recurrent rate of multicentric papillary thyroid carcinoma. ( 19533244 )
2009
2
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. ( 7137085 )
1982

Variations for Multicentric Papillary Thyroid Carcinoma

Cosmic variations for Multicentric Papillary Thyroid Carcinoma:

9
(show top 50) (show all 293)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6961574 ZFHX3 thyroid,NS,carcinoma,papillary carcinoma c.5539C>T p.Q1847* 16:72797143-72797143 7
2 COSM6954354 VTCN1 thyroid,NS,carcinoma,papillary carcinoma c.399C>G p.I133M 1:117156620-117156620 7
3 COSM17721 VHL thyroid,NS,carcinoma,papillary carcinoma c.241C>T p.P81S 3:10142088-10142088 7
4 COSM26416 TSHR thyroid,NS,carcinoma,papillary carcinoma c.1867G>T p.A623S 14:81143925-81143925 7
5 COSM26449 TSHR thyroid,NS,carcinoma,papillary carcinoma c.1358T>C p.M453T 14:81143416-81143416 7
6 COSM6918838 TSC2 thyroid,NS,carcinoma,papillary carcinoma c.4468G>C p.E1490Q 16:2084690-2084690 7
7 COSM10704 TP53 thyroid,NS,carcinoma,papillary carcinoma c.844C>T p.R282W 17:7673776-7673776 7
8 COSM10739 TP53 thyroid,NS,carcinoma,papillary carcinoma c.481G>A p.A161T 17:7675131-7675131 7
9 COSM43980 TP53 thyroid,NS,carcinoma,papillary carcinoma c.691A>G p.T231A 17:7674272-7674272 7
10 COSM10863 TP53 thyroid,NS,carcinoma,papillary carcinoma c.833C>T p.P278L 17:7673787-7673787 7
11 COSM44988 TP53 thyroid,NS,carcinoma,papillary carcinoma c.374C>T p.T125M 17:7675995-7675995 7
12 COSM10771 TP53 thyroid,NS,carcinoma,papillary carcinoma c.749C>T p.P250L 17:7674214-7674214 7
13 COSM10659 TP53 thyroid,NS,carcinoma,papillary carcinoma c.817C>T p.R273C 17:7673803-7673803 7
14 COSM10834 TP53 thyroid,NS,carcinoma,papillary carcinoma c.711G>A p.M237I 17:7674252-7674252 7
15 COSM10867 TP53 thyroid,NS,carcinoma,papillary carcinoma c.797G>A p.G266E 17:7673823-7673823 7
16 COSM44225 TP53 thyroid,NS,carcinoma,papillary carcinoma c.859G>A p.E287K 17:7673761-7673761 7
17 COSM6959677 SYK thyroid,NS,carcinoma,papillary carcinoma c.65G>A p.R22Q 9:90843963-90843963 7
18 COSM6974249 SPEN thyroid,NS,carcinoma,papillary carcinoma c.10348C>T p.Q3450* 1:15937484-15937484 7
19 COSM14195 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.1482C>T p.D494D 18:51078290-51078290 7
20 COSM14186 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.788A>G p.N263S 18:51058340-51058340 7
21 COSM14163 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.931C>T p.Q311* 18:51059892-51059892 7
22 COSM14185 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.676G>A p.A226T 18:51058133-51058133 7
23 COSM14189 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.971G>A p.C324Y 18:51065438-51065438 7
24 COSM14196 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.1648C>T p.P550S 18:51078456-51078456 7
25 COSM14193 SMAD4 thyroid,NS,carcinoma,papillary carcinoma c.1487G>A p.R496H 18:51078295-51078295 7
26 COSM3407453 SF3B1 thyroid,NS,carcinoma,papillary carcinoma c.1781G>A p.R594Q 2:197402974-197402974 7
27 COSM6954357 SETD2 thyroid,NS,carcinoma,papillary carcinoma c.3247C>G p.H1083D 3:47106080-47106080 7
28 COSM6945083 RICTOR thyroid,NS,carcinoma,papillary carcinoma c.2539C>T p.L847F 5:38955665-38955665 7
29 COSM3390655 RBM10 thyroid,NS,carcinoma,papillary carcinoma c.2548C>T p.Q850* 23:47186268-47186268 7
30 COSM6981514 RBM10 thyroid,NS,carcinoma,papillary carcinoma c.853C>T p.Q285* 23:47179447-47179447 7
31 COSM6944613 RBM10 thyroid,NS,carcinoma,papillary carcinoma c.1573C>T p.Q525* 23:47181644-47181644 7
32 COSM6917469 RAD51B thyroid,NS,carcinoma,papillary carcinoma c.940G>C p.D314H 14:68411510-68411510 7
33 COSM6944180 RAD50 thyroid,NS,carcinoma,papillary carcinoma c.3057A>T p.Q1019H 5:132637199-132637199 7
34 COSM6923704 PTPRT thyroid,NS,carcinoma,papillary carcinoma c.3655G>T p.G1219W 20:42102249-42102249 7
35 COSM6961568 PTPRD thyroid,NS,carcinoma,papillary carcinoma c.1616C>G p.P539R 9:8507362-8507362 7
36 COSM13015 PTPN11 thyroid,NS,carcinoma,papillary carcinoma c.215C>T p.A72V 12:112450395-112450395 7
37 COSM5092 PTEN thyroid,NS,carcinoma,papillary carcinoma c.385G>A p.G129R 10:87933144-87933144 7
38 COSM5064 PTEN thyroid,NS,carcinoma,papillary carcinoma c.44G>A p.R15K 10:87864513-87864513 7
39 COSM4016454 PTEN thyroid,NS,carcinoma,papillary carcinoma c.295G>A p.E99K 10:87933054-87933054 7
40 COSM5034 PTEN thyroid,NS,carcinoma,papillary carcinoma c.425G>A p.R142Q 10:87933184-87933184 7
41 COSM3394847 PMS2 thyroid,NS,carcinoma,papillary carcinoma c.206C>T p.S69L 7:6004016-6004016 7
42 COSM1666844 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.977C>T p.S326F 3:179203707-179203707 7
43 COSM775 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.3140A>G p.H1047R 3:179234297-179234297 7
44 COSM763 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.1633G>A p.E545K 3:179218303-179218303 7
45 COSM29106 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.1658G>A p.S553N 3:179218328-179218328 7
46 COSM29110 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.3115T>C p.F1039L 3:179234272-179234272 7
47 COSM33701 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.1589A>G p.Q530R 3:179218259-179218259 7
48 COSM776 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.3140A>T p.H1047L 3:179234297-179234297 7
49 COSM778 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.2102A>C p.H701P 3:179221072-179221072 7
50 COSM12597 PIK3CA thyroid,NS,carcinoma,papillary carcinoma c.3145G>C p.G1049R 3:179234302-179234302 7

Expression for Multicentric Papillary Thyroid Carcinoma

Search GEO for disease gene expression data for Multicentric Papillary Thyroid Carcinoma.

Pathways for Multicentric Papillary Thyroid Carcinoma

GO Terms for Multicentric Papillary Thyroid Carcinoma

Cellular components related to Multicentric Papillary Thyroid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 PNLIP SPN TG

Sources for Multicentric Papillary Thyroid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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