MCID: MLT016
MIFTS: 39

Multicentric Reticulohistiocytosis

Categories: Bone diseases, Muscle diseases, Rare diseases, Skin diseases

Aliases & Classifications for Multicentric Reticulohistiocytosis

MalaCards integrated aliases for Multicentric Reticulohistiocytosis:

Name: Multicentric Reticulohistiocytosis 12 73 20 58 15
Lipoid Dermatoarthritis 12 58 70 32
Giant Cell Histiocytomatosis 58

Characteristics:

Orphanet epidemiological data:

58
multicentric reticulohistiocytosis
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:11824
NCIt 50 C27896
SNOMED-CT 67 84241008
ICD10 32 E78.81 M14.3
ICD10 via Orphanet 33 D76.3
UMLS via Orphanet 71 C0311284
Orphanet 58 ORPHA139436
UMLS 70 C0311284

Summaries for Multicentric Reticulohistiocytosis

GARD : 20 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. The disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.

MalaCards based summary : Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to ankylosis and langerhans cell histiocytosis. An important gene associated with Multicentric Reticulohistiocytosis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include bone marrow, skin and breast, and related phenotypes are arthritis and skin nodule

Disease Ontology : 12 A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia : 73 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50... more...

Related Diseases for Multicentric Reticulohistiocytosis

Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 ankylosis 30.2 TNFSF11 TNFRSF11B
2 langerhans cell histiocytosis 30.2 F13A1 CSF1 CD68
3 mammary paget's disease 30.0 TNFSF11 TNFRSF11B
4 synovitis 29.9 TNFSF11 TNFRSF11B CD68
5 reticulohistiocytic granuloma 29.8 SERPINA3 CD68 CD1E
6 bone resorption disease 29.7 TNFSF11 TNFRSF11B SERPINA3 CSF1
7 bone disease 29.6 TNFSF11 TNFRSF11B CSF1
8 non-langerhans-cell histiocytosis 29.6 SERPINA3 F13A1 CD68 CD1E
9 granuloma annulare 29.6 VIM F13A1 CD68 CD1E
10 adult xanthogranuloma 29.3 SERPINA3 CD68 CD1E
11 histiocytosis 10.6
12 rare systemic disease 10.5
13 dermatomyositis 10.5
14 arthropathy 10.4
15 exanthem 10.3
16 tumor of meninges 10.3 VIM F13A1
17 rheumatoid arthritis 10.3
18 plica syndrome 10.3
19 gout 10.3
20 angiolipoma 10.2 VIM F13A1
21 fibrous meningioma 10.2 VIM F13A1
22 scleroderma, familial progressive 10.2
23 psoriatic arthritis 10.2
24 enthesopathy 10.2
25 bone giant cell sarcoma 10.2 TNFSF11 CSF1
26 erythema elevatum diutinum 10.2 F13A1 CD1E
27 polyarticular onset juvenile idiopathic arthritis 10.1 TNFSF11 TNFRSF11B
28 hemophilic arthropathy 10.1 TNFSF11 TNFRSF11B
29 periodontitis, chronic 10.1 TNFSF11 TNFRSF11B
30 disseminated chorioretinitis 10.1 TNFSF11 TNFRSF11B
31 mandibular cancer 10.1 TNFSF11 CSF1
32 paget disease of bone 5, juvenile-onset 10.1 TNFSF11 TNFRSF11B
33 central epithelioid sarcoma 10.1 VIM CD1E
34 vulvar proximal-type epithelioid sarcoma 10.1 VIM CD1E
35 osteopetrosis, autosomal recessive 7 10.1 TNFSF11 CSF1
36 optic nerve glioma 10.1 VIM TNFRSF11B
37 chronic apical periodontitis 10.1 TNFSF11 TNFRSF11B
38 intravascular papillary endothelial hyperplasia 10.1 VIM SERPINA3
39 autoimmune disease 10.1
40 leprosy 3 10.1
41 lepromatous leprosy 10.1
42 hemopericardium 10.1
43 pericardial effusion 10.1
44 melanoma 10.1
45 benign mesothelioma 10.1
46 thymic carcinoma 10.1
47 pulmonary fibrosis 10.1
48 myopathy 10.1
49 connective tissue disease 10.1
50 osteoarthritis 10.1

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to Multicentric Reticulohistiocytosis

Symptoms & Phenotypes for Multicentric Reticulohistiocytosis

Human phenotypes related to Multicentric Reticulohistiocytosis:

58 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001369
2 skin nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200036
3 histiocytosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100727
4 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
5 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
6 cachexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0004326

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

Search Clinical Trials , NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

Anatomical Context for Multicentric Reticulohistiocytosis

MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

40
Bone Marrow, Skin, Breast, Bone, Liver, Colon, Thyroid

Publications for Multicentric Reticulohistiocytosis

Articles related to Multicentric Reticulohistiocytosis:

(show top 50) (show all 373)
# Title Authors PMID Year
1
Paraneoplastic Multicentric Reticulohistiocytosis on 18F-FDG PET/CT Breast Carcinoma Follow-up. 61
33323726 2021
2
Multicentric reticulohistiocytosis: an association with chronic sagittal sinus thrombosis. 61
32875639 2021
3
Multicentric reticulohistiocytosis: A case report treated with tofacitinib. 61
32173071 2021
4
Skin Manifestation Associated With Multicentric Reticulohistiocytosis. 61
33337805 2020
5
Multicentric Reticulohistiocytosis: A Case with Minimal Cutaneous Features. 61
33235866 2020
6
Multicentric Reticulohistiocytosis Exhibiting Positive HLA-B*07 and HLA-B*08: A Case Report. 61
32911791 2020
7
Multicentric Reticulohistiocytosis in a Patient with Hand Contracture. 61
32522928 2020
8
Multicentric reticulohistiocytosis: A case report with response to adalimumab. 61
32884795 2020
9
Reticulohistiocytoses: a revision of the full spectrum. 61
31955466 2020
10
Multicentric reticulohistiocytosis: the Mayo Clinic experience (1980-2017). 61
31742640 2020
11
"Coral bead sign" in Multicentric Reticulohistiocytosis. 61
31782143 2020
12
Multicentric Reticulohistiocytosis: Elective Excision of Symptomatic Hand Nodules With 1-Year Follow-Up. 61
31320232 2020
13
Targetable driver mutations in multicentric reticulohistiocytosis. 61
31171640 2020
14
Scleroderma with Acro-Osteolysis and Papular Mucinosis Resembling Multicentric Reticulohistiocytosis. 61
32789122 2020
15
Fluorodeoxyglucose PET/CT of Arthritis in Rheumatic Diseases: A Pictorial Review. 61
31917663 2020
16
Multicentric reticulohistiocytosis in the course of undifferentiated connective tissue disease. 61
31839786 2019
17
Multicentric reticulohistiocytosis in a patient with thymic carcinoma. 61
31440567 2019
18
A Rare Case of Multicentric Reticulohistiocytosis with Concurrent Rheumatoid Arthritis. 61
31646135 2019
19
Cutaneous paraneoplastic syndromes. 61
30736994 2019
20
Atypical presentation of paraneoplastic multicentric reticulohistiocytosis associated with breast cancer relapse. 61
31148348 2019
21
Multicentric reticulohistiocytosis with arthralgia and red-orange papulonodules. 61
30758349 2019
22
Thalidomide, A Rational Agent for Treatment of Multicentric Reticulohistiocytosis. 61
32529194 2019
23
[Multicentric reticulohistiocytosis]. 61
30264314 2018
24
The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report: Erratum. 61
30235781 2018
25
Multicentric reticulohistiocytosis: a case report. 61
30180908 2018
26
The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. 61
30113451 2018
27
Xanthomatous Multicentric Reticulohistiocytosis: An Underrecognized Variant. 61
29239933 2018
28
Rare case of multicentric reticulohistiocytosis presenting as epidermotropic papular xanthoma and double primary cancers. 61
29277932 2018
29
Multicentric reticulohistiocytosis and metastatic colon carcinoma: an uncommon neoplasm recurrence manifestation. 61
29766711 2018
30
A case of photodistributed multicentric reticulohistiocytosis: correlation with multiphoton microscopy imaging. 61
29697904 2018
31
Rare diseases of bone: Erdheim-Chester and Rosai-Dorfman non-Langerhans cell histiocytoses. 61
30034819 2018
32
[Multicentric reticulohistiocytosis is a rare form of paraneoplasia]. 61
29298742 2018
33
Multicentric Reticulohistiocytosis: A Multicenter Case Series and Review of Literature. 61
29059085 2018
34
Multicentric reticulohistiocytosis associated with thymic carcinoma. 61
28633354 2017
35
Dermoscopic features of periungual papules in multicentric reticulohistiocytosis. 61
28382775 2017
36
Involvement of M2 macrophages in the pathomechanisms of multicentric reticulohistiocytosis. 61
28556889 2017
37
Multicentric reticulohistiocytosis misdiagnosed as tenosynovial giant cell tumour. 61
28968849 2017
38
Multicentric Reticulohistiocytosis Mimicking Malignancy on 18F-FDG PET/CT. 61
28368895 2017
39
Looks Can Be Deceiving: A Case Report on Multicentric Reticulohistiocytosis Successfully Treated with Rituximab. 61
28589069 2017
40
Multicentric Reticulohistiocytosis with Dermatomyositis-like Eruptions. 61
28768982 2017
41
A case of multicentric reticulohistiocytosis. 61
25211404 2017
42
Multicentric Reticulohistiocytosis: an Unknown Source of Embolic Stroke. 61
27839900 2017
43
Metastatic Inflammatory Breast Cancer Associated With Multicentric Reticulohistiocytosis Successfully Treated With Zoledronic Acid. 61
27435627 2016
44
Multicentric Reticulohistiocytosis in a 5-Year-Old Girl. 61
27492868 2016
45
Multicentric Reticulohistiocytosis: A Unique Case of Chronic Colitis. 61
27580770 2016
46
Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. 61
27175854 2016
47
Nailfold Capillary Patterns in a Patient With Multicentric Reticulohistiocytosis and Raynaud Phenomenon. 61
27219314 2016
48
Efficacy of Vinblastine and Prednisone in Multicentric Reticulohistiocytosis With Onset in Infancy. 61
27199388 2016
49
Cutaneous manifestations of breast cancer. 61
27178684 2016
50
The cutaneous manifestations of gastrointestinal malignancy. 61
27178686 2016

Variations for Multicentric Reticulohistiocytosis

Expression for Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for Multicentric Reticulohistiocytosis

GO Terms for Multicentric Reticulohistiocytosis

Cellular components related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 TNFSF11 TNFRSF11B SERPINA3 CSF1 CD1E

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoclast differentiation GO:0030316 9.26 TNFSF11 CSF1
2 cytokine-mediated signaling pathway GO:0019221 9.26 VIM TNFSF11 F13A1 CSF1
3 positive regulation of osteoclast differentiation GO:0045672 9.16 TNFSF11 CSF1
4 osteoclast proliferation GO:0002158 8.62 TNFSF11 CSF1

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TNFSF11 TNFRSF11B CSF1

Sources for Multicentric Reticulohistiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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