MCID: MLT016
MIFTS: 46

Multicentric Reticulohistiocytosis

Categories: Bone diseases, Rare diseases, Skin diseases

Aliases & Classifications for Multicentric Reticulohistiocytosis

MalaCards integrated aliases for Multicentric Reticulohistiocytosis:

Name: Multicentric Reticulohistiocytosis 12 76 53 59 15
Lipoid Dermatoarthritis 12 59 73
Giant Cell Histiocytomatosis 59

Characteristics:

Orphanet epidemiological data:

59
multicentric reticulohistiocytosis
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:11824
ICD10 33 E78.81 M14.3
NCIt 50 C27896
SNOMED-CT 68 84241008
Orphanet 59 ORPHA139436
ICD10 via Orphanet 34 D76.3
UMLS via Orphanet 74 C0311284
UMLS 73 C0311284

Summaries for Multicentric Reticulohistiocytosis

NIH Rare Diseases : 53 Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans. The disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.

MalaCards based summary : Multicentric Reticulohistiocytosis, also known as lipoid dermatoarthritis, is related to granuloma annulare and arthropathy. An important gene associated with Multicentric Reticulohistiocytosis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, bone and liver, and related phenotypes are muscle weakness and arthritis

Disease Ontology : 12 A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis.

Wikipedia : 76 Multicentric reticulohistiocytosis is a multisystem disease beginning usually around the age of 50... more...

Related Diseases for Multicentric Reticulohistiocytosis

Diseases related to Multicentric Reticulohistiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 granuloma annulare 30.3 F13A1 VIM
2 arthropathy 29.8 TNFRSF11B TNFSF11
3 rheumatoid arthritis 29.8 CSF1 TNFRSF11B TNFSF11
4 bone resorption disease 29.6 TNFRSF11B TNFSF11
5 psoriatic arthritis 29.4 TNFRSF11B TNFSF11
6 arthritis 10.5
7 dermatomyositis 10.3
8 angiolipoma 10.1 F13A1 VIM
9 fibrous meningioma 10.1 F13A1 VIM
10 villonodular synovitis 10.1 TNFSF11 VIM
11 juvenile xanthogranuloma 10.1 F13A1 VIM
12 cutaneous fibrous histiocytoma 10.1 F13A1 VIM
13 fibrous histiocytoma 10.1 F13A1 VIM
14 primitive neuroectodermal tumor of the cervix uteri 10.1 PTPRC VIM
15 retroperitoneal fibrosis 10.1 PTPRC VIM
16 hemangiopericytoma, malignant 10.1 F13A1 VIM
17 reticulum cell sarcoma 10.1 PTPRC VIM
18 extraskeletal ewing sarcoma 10.1 PTPRC VIM
19 mucinous cystadenocarcinoma 10.1 PTPRC VIM
20 dendritic cell tumor 10.1 PTPRC VIM
21 bone giant cell tumor 10.1 TNFSF11 VIM
22 rhabdoid tumor predisposition syndrome 1 10.0 PTPRC VIM
23 scleroderma, familial progressive 10.0
24 lymphoma 10.0
25 lepromatous leprosy 10.0
26 melanoma 10.0
27 myoepithelioma 10.0 PTPRC VIM
28 osteopetrosis, autosomal recessive 7 10.0 CSF1 TNFSF11
29 osteopetrosis 10.0 CSF1 TNFSF11
30 mandibular cancer 10.0 CSF1 TNFSF11
31 dermatofibrosarcoma protuberans 10.0 F13A1 VIM
32 joint disorders 10.0 CSF1 TNFSF11
33 cherubism 10.0 CSF1 TNFSF11
34 synovitis 10.0 TNFRSF11B TNFSF11
35 polyarticular onset juvenile idiopathic arthritis 10.0 TNFRSF11B TNFSF11
36 hemophilic arthropathy 10.0 TNFRSF11B TNFSF11
37 kummell's disease 10.0 TNFRSF11B TNFSF11
38 paget disease of bone 5, juvenile-onset 10.0 TNFRSF11B TNFSF11
39 periodontitis, chronic 9.9 TNFRSF11B TNFSF11
40 periodontitis 9.9 TNFRSF11B TNFSF11
41 chronic apical periodontitis 9.9 TNFRSF11B TNFSF11
42 malignant fibroxanthoma 9.9 F13A1 PTPRC VIM
43 familial expansile osteolysis 9.9 TNFRSF11B TNFSF11
44 multicentric carpotarsal osteolysis syndrome 9.9 TNFRSF11B TNFSF11
45 periapical periodontitis 9.9 TNFRSF11B TNFSF11
46 optic nerve glioma 9.9 TNFRSF11B VIM
47 tooth resorption 9.9 TNFRSF11B TNFSF11
48 glucocorticoid-induced osteoporosis 9.9 TNFRSF11B TNFSF11
49 ischemic bone disease 9.9 TNFRSF11B TNFSF11
50 root resorption 9.9 TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Multicentric Reticulohistiocytosis:



Diseases related to Multicentric Reticulohistiocytosis

Symptoms & Phenotypes for Multicentric Reticulohistiocytosis

Human phenotypes related to Multicentric Reticulohistiocytosis:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
2 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
3 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
4 cachexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004326
5 skin nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200036
6 histiocytosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100727

GenomeRNAi Phenotypes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.77 CSF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.77 VIM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.77 CSF1 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.77 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.77 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.77 CSF1 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.77 VIM
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.77 CSF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.77 CSF1 TNFSF11 VIM
10 Reduced mammosphere formation GR00396-S 8.92 CSF1 F13A1 PTPRC VIM

MGI Mouse Phenotypes related to Multicentric Reticulohistiocytosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CSF1 F13A1 PTPRC TNFRSF11B TNFSF11 VIM
2 immune system MP:0005387 9.55 CSF1 PTPRC TNFRSF11B TNFSF11 VIM
3 mortality/aging MP:0010768 9.43 CSF1 F13A1 PTPRC TNFRSF11B TNFSF11 VIM
4 respiratory system MP:0005388 9.02 CSF1 F13A1 PTPRC TNFSF11 VIM

Drugs & Therapeutics for Multicentric Reticulohistiocytosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Rare Histiocytic Disorders Registry (IRHDR) Recruiting NCT02285582

Search NIH Clinical Center for Multicentric Reticulohistiocytosis

Genetic Tests for Multicentric Reticulohistiocytosis

Anatomical Context for Multicentric Reticulohistiocytosis

MalaCards organs/tissues related to Multicentric Reticulohistiocytosis:

41
Skin, Bone, Liver, Lung, Thyroid, Salivary Gland, Bone Marrow

Publications for Multicentric Reticulohistiocytosis

Articles related to Multicentric Reticulohistiocytosis:

(show top 50) (show all 259)
# Title Authors Year
1
A case of photodistributed multicentric reticulohistiocytosis: correlation with multiphoton microscopy imaging. ( 29697904 )
2018
2
Multicentric reticulohistiocytosis and metastatic colon carcinoma: an uncommon neoplasm recurrence manifestation. ( 29766711 )
2018
3
Multicentric Reticulohistiocytosis: A Multicenter Case Series and Review of Literature. ( 29059085 )
2018
4
The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. ( 30113451 )
2018
5
Multicentric reticulohistiocytosis: a case report. ( 30180908 )
2018
6
The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report: Erratum. ( 30235781 )
2018
7
Involvement of M2 macrophages in the pathomechanisms of multicentric reticulohistiocytosis. ( 28556889 )
2017
8
Multicentric Reticulohistiocytosis Mimicking Malignancy on 18F-FDG PET/CT. ( 28368895 )
2017
9
Rare case of multicentric reticulohistiocytosis presenting as epidermotropic papular xanthoma and double primary cancers. ( 29277932 )
2017
10
Multicentric reticulohistiocytosis associated with thymic carcinoma. ( 28633354 )
2017
11
Multicentric Reticulohistiocytosis: an Unknown Source of Embolic Stroke. ( 27839900 )
2017
12
Dermoscopic features of periungual papules in multicentric reticulohistiocytosis. ( 28382775 )
2017
13
Multicentric reticulohistiocytosis misdiagnosed as tenosynovial giant cell tumour. ( 28968849 )
2017
14
Multicentric Reticulohistiocytosis with Dermatomyositis-like Eruptions. ( 28768982 )
2017
15
Xanthomatous Multicentric Reticulohistiocytosis: An Underrecognized Variant. ( 29239933 )
2017
16
Looks Can Be Deceiving: A Case Report on Multicentric Reticulohistiocytosis Successfully Treated with Rituximab. ( 28589069 )
2017
17
Multicentric reticulohistiocytosis: Rheumatology perspective. ( 27886798 )
2016
18
Metastatic Inflammatory Breast Cancer Associated With Multicentric Reticulohistiocytosis Successfully Treated With Zoledronic Acid. ( 27435627 )
2016
19
Efficacy of Vinblastine and Prednisone in Multicentric Reticulohistiocytosis With Onset in Infancy. ( 27199388 )
2016
20
Multicentric reticulohistiocytosis (MRH): case report with review of literature between 1991 and 2014 with in depth analysis of various treatment regimens and outcomes. ( 27026876 )
2016
21
Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. ( 26652057 )
2016
22
Multicentric Reticulohistiocytosis: A Unique Case of Chronic Colitis. ( 27580770 )
2016
23
Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence. ( 27175854 )
2016
24
Nailfold Capillary Patterns in a Patient With Multicentric Reticulohistiocytosis and Raynaud Phenomenon. ( 27219314 )
2016
25
Multicentric Reticulohistiocytosis in a 5-Year-Old Girl. ( 27492868 )
2016
26
Successful Treatment of Multicentric Reticulohistiocytosis with Adalimumab, Prednisolone and Methotrexate. ( 26072967 )
2015
27
18F-FDG PET/CT Findings in Multicentric Reticulohistiocytosis. ( 26571445 )
2015
28
Multicentric Reticulohistiocytosis: A Case Report of an Atypical Presentation in a 2-Year-Old. ( 25727569 )
2015
29
Bilateral Total Hip Arthroplasty in a Rare Case of Multicentric Reticulohistiocytosis. ( 26640636 )
2015
30
Erythema, papules, and arthralgia associated with liver cancer: report of a rare case of multicentric reticulohistiocytosis. ( 26045857 )
2015
31
Multicentric reticulohistiocytosis: a critical review. ( 25900189 )
2015
32
Organizing pneumonia associated with multicentric reticulohistiocytosis. ( 26740877 )
2015
33
A case of multicentric reticulohistiocytosis. ( 25211404 )
2014
34
Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options. ( 24733253 )
2014
35
Multicentric reticulohistiocytosis can mimic rheumatoid arthritis. ( 24692603 )
2014
36
Multicentric reticulohistiocytosis. ( 25092372 )
2014
37
Multicentric reticulohistiocytosis misdiagnosed as rheumatoid arthritis. ( 25040783 )
2014
38
Multicentric reticulohistiocytosis: contrasting presentations in 2 Hispanic patients. ( 24897136 )
2014
39
Multicentric reticulohistiocytosis: a rare yet challenging disease. ( 23417597 )
2013
40
Granuloma annulare mimicking multicentric reticulohistiocytosis. ( 24314776 )
2013
41
Hand surgery for Multicentric Reticulohistiocytosis: A new avenue of treatment and review of the literature. ( 23796955 )
2013
42
Multicentric reticulohistiocytosis presenting with papulonodular skin lesions and arthritis mutilans. ( 23555066 )
2013
43
Treatment of multicentric reticulohistiocytosis with tocilizumab. ( 23872542 )
2013
44
The usefulness of the scan with 67Ga-citrate in the multicentric reticulohistiocytosis. ( 23219024 )
2013
45
Multicentric reticulohistiocytosis. ( 22945300 )
2013
46
Multicentric reticulohistiocytosis with extra-mammillary Paget's disease: a case report. ( 24168966 )
2013
47
Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate. ( 23441782 )
2013
48
Treatment of facial lesions of multicentric reticulohistiocytosis by carbon dioxide laser. ( 24163535 )
2013
49
Multicentric reticulohistiocytosis and fibroblastic rheumatism. ( 23040366 )
2012
50
Overexpression of monocyte chemoattractant protein-1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: a case report. ( 22435444 )
2012

Variations for Multicentric Reticulohistiocytosis

Expression for Multicentric Reticulohistiocytosis

Search GEO for disease gene expression data for Multicentric Reticulohistiocytosis.

Pathways for Multicentric Reticulohistiocytosis

GO Terms for Multicentric Reticulohistiocytosis

Biological processes related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.58 CSF1 TNFRSF11B TNFSF11
2 positive regulation of gene expression GO:0010628 9.54 CSF1 TNFSF11 VIM
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11B TNFSF11
4 positive regulation of protein kinase activity GO:0045860 9.32 CSF1 PTPRC
5 osteoclast differentiation GO:0030316 9.26 CSF1 TNFSF11
6 cytokine-mediated signaling pathway GO:0019221 9.26 CSF1 F13A1 TNFSF11 VIM
7 positive regulation of osteoclast differentiation GO:0045672 9.16 CSF1 TNFSF11
8 osteoclast proliferation GO:0002158 8.62 CSF1 TNFSF11

Molecular functions related to Multicentric Reticulohistiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CSF1 TNFRSF11B TNFSF11

Sources for Multicentric Reticulohistiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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