MCID: MLT035
MIFTS: 31

Multifocal Choroiditis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Multifocal Choroiditis

MalaCards integrated aliases for Multifocal Choroiditis:

Name: Multifocal Choroiditis 20 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 71 C1533060

Summaries for Multifocal Choroiditis

GARD : 20 Multifocal choroiditis (MFC) is an inflammatory disorder characterized by swelling of the eye (called uveitis) and multiple lesions in the choroid, a layer of blood vessels between the white of the eye and the retina. Symptoms include blurry vision, floaters, sensitivity to light, blind spots and mild eye discomfort. Though the cause is unknown, multifocal choroiditis is seen most frequently in women ages 20 to 60, and usually affects both eyes. MFC is generally treated with steroid medication that can be taken orally or injected into the eye. Multifocal choroiditis is a chronic condition, thus symptoms may return or worsen even after successful treatment.

MalaCards based summary : Multifocal Choroiditis is related to panuveitis and macular retinal edema. An important gene associated with Multifocal Choroiditis is CFB (Complement Factor B), and among its related pathways/superpathways are IgA-Producing B Cells in the Intestine and Malaria. The drugs Fluconazole and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Related Diseases for Multifocal Choroiditis

Diseases related to Multifocal Choroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.9 TNF IL10
2 macular retinal edema 30.8 TNF CFH
3 punctate inner choroidopathy 30.8 TNF IL10
4 iridocyclitis 30.5 TNF IL10
5 histoplasmosis 30.4 TNF CFH ARMS2
6 posterior uveitis 30.4 TNF CFH
7 chorioretinitis 30.2 TNF IL10
8 retinal disease 30.1 CFH CFB ARMS2
9 degenerative myopia 30.1 CFH ARMS2
10 exanthem 30.0 TNF IL10
11 herpes zoster 30.0 TNF IL10
12 blau syndrome 29.9 TNF IL10
13 choroiditis 29.8 TNF IL10 HTRA1 CFH CFB ARMS2
14 iritis 29.8 TNF IL10
15 cryptococcosis 29.7 TNF IL10
16 typhoid fever 29.7 TNF HTRA1
17 graft-versus-host disease 29.6 TNF IL10
18 hepatitis a 29.6 TNF IL10
19 macular degeneration, age-related, 1 28.8 TNF IL10 HTRA1 CFH CFB ARMS2
20 eye disease 28.2 TNF IL10 HTRA1 CFH CFB ARMS2
21 uveitis 10.6
22 pars planitis 10.4
23 retinal detachment 10.3
24 sarcoidosis 1 10.3
25 myopia 10.3
26 acute posterior multifocal placoid pigment epitheliopathy 10.3
27 microvascular complications of diabetes 5 10.2
28 optic nerve disease 10.2
29 scotoma 10.2
30 atypical hemolytic uremic syndrome with complement gene abnormality 10.2 CFH CFB
31 dense deposit disease 10.2 CFH CFB
32 genetic atypical hemolytic-uremic syndrome 10.2 CFH CFB
33 c3 glomerulopathy 10.2 CFH CFB
34 macular degeneration, age-related, 6 10.2 CFH CFB
35 macular degeneration, age-related, 4 10.2 CFH CFB
36 methylmalonic aciduria and homocystinuria, cblc type 10.2 CFH CFB
37 complement deficiency 10.2 CFH CFB
38 neuropathy 10.2
39 central serous chorioretinopathy 10.1 CFH ARMS2
40 bullous retinoschisis 10.1 CFH ARMS2
41 haemophilus influenzae 10.1 TNF CFH
42 louse-borne relapsing fever 10.1 TNF CFH
43 relapsing fever 10.1 TNF CFH
44 angioid streaks 10.1 CFH ARMS2
45 doyne honeycomb retinal dystrophy 10.1 CFH ARMS2
46 macular degeneration, age-related, 8 10.1 TNF ARMS2
47 membranoproliferative glomerulonephritis 10.1 CFH CFB
48 cardiomyopathy, dilated, 1l 10.1 HTRA1 CFH
49 pfeiffer syndrome 10.1
50 human immunodeficiency virus type 1 10.1

Graphical network of the top 20 diseases related to Multifocal Choroiditis:



Diseases related to Multifocal Choroiditis

Symptoms & Phenotypes for Multifocal Choroiditis

Drugs & Therapeutics for Multifocal Choroiditis

Drugs for Multifocal Choroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational 86386-73-4 3365
2
Bevacizumab Approved, Investigational 216974-75-3
3 Antineoplastic Agents, Immunological
4 Angiogenesis Inhibitors
5 Mitogens
6 Endothelial Growth Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03897192 Bevacizumab
2 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03793400 Bevacizumab Injection

Search NIH Clinical Center for Multifocal Choroiditis

Genetic Tests for Multifocal Choroiditis

Anatomical Context for Multifocal Choroiditis

MalaCards organs/tissues related to Multifocal Choroiditis:

40
Eye, Retina, Endothelial, Bone Marrow

Publications for Multifocal Choroiditis

Articles related to Multifocal Choroiditis:

(show top 50) (show all 353)
# Title Authors PMID Year
1
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis. 61
32115264 2021
2
Use of multimodal analysis in the diagnosis and follow-up of a case of Acute Zonal Occult Outer Retinopathy (AZOOR). 61
33485739 2021
3
The efficacy of adalimumab in treating patients with central multifocal choroiditis. 61
33024886 2020
4
The efficacy of corticosteroid-sparing immunomodulatory therapy in treating patients with central multifocal choroiditis. 61
32410393 2020
5
Case report of post streptococcal multifocal choroiditis in a young pregnant female: A success story. 61
33196327 2020
6
Ocular manifestations of Blau syndrome. 61
33009086 2020
7
Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors. 61
32621891 2020
8
Choriocapillaris Involvement in Acute Syphilis Posterior Placoid Chorioretinitis is Responsible for Functional Impairment and Points towards an Immunologic Mechanism: A Comprehensive Clinicopathological Approach. 61
33553841 2020
9
Distribution and Progression of Inflammatory Chorioretinal Lesions Related to Multifocal Choroiditis and Their Correlations with Clinical Outcomes at 24 Months. 61
32946308 2020
10
Expanding the Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Overlapping Multifocal Choroiditis. 61
32870040 2020
11
Lichen planus and multifocal choroiditis - A diagnostic dilemma. 61
32823424 2020
12
Giant macular hole in a case of multifocal choroiditis. 61
32823423 2020
13
Ocular manifestations of Blau syndrome. 61
32897920 2020
14
Rapid and spontaneous resolution of hemorrhagic macular hole retinal detachment and subretinal hemorrhages in an eye with pathologic myopia: a case report. 61
32993567 2020
15
Acute Idiopathic Blind Spot Enlargement and Acute Zonal Occult Outer Retinopathy: Potential Mimics of Neuro-Ophthalmic Disease. 61
32796345 2020
16
Multifocal Choroiditis Secondary to Acute Zika Virus Infection. 61
31567025 2020
17
Unilateral multifocal choroiditis following EBV-positive mononucleosis responsive to immunosuppression: a case report. 61
32646392 2020
18
Treatment of Vogt-Koyanagi-Harada Disease. 61
32789066 2020
19
Differentiating Multifocal Choroiditis and Punctate Inner Choroidopathy: A Cluster Analysis Approach. 61
32027868 2020
20
The "Sponge sign": A novel feature of inflammatory choroidal neovascularization. 61
32345048 2020
21
Localized Peripheral Vitritis on OCT in Multifocal Choroiditis and Panuveitis. 61
32273110 2020
22
Masqueraders of multiple evanescent white dot syndrome (MEWDS). 61
31792848 2020
23
Complicated Retinal Pigment Epithelium Humps in High Myopia. 61
32084286 2020
24
SPIRONOLACTONE AS A THERAPEUTIC ALTERNATIVE FOR THE BULLOUS VARIANT OF CENTRAL SEROUS CHORIORETINOPATHY. 61
29595560 2020
25
Newer trends in tubercular uveitis: a case series with systemic correlation. 61
33215004 2020
26
Long-Term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis with Active Choroidal Neovascularization Managed with Intravitreal Bevacizumab. 61
30994378 2020
27
Long-term Outcome of Zonal Outer Retinopathy in Punctate Inner Choroidopathy or Multifocal Choroiditis. 61
31906767 2020
28
Inflammatory Choroidal Neovascular Membranes in Patients With Noninfectious Uveitis: The Place of Intravitreal Anti-VEGF Therapy. 61
32490018 2020
29
[White dot syndromes : Principles, diagnostics, and treatment]. 61
31748943 2019
30
The Nature and Frequency of Outer Retinal Disruption in Idiopathic Multifocal Choroiditis Associated With Persistent Fundus Hyperautofluorescence. 61
31755966 2019
31
LATE RECURRENCE OF CHOROIDAL NEOVASCULARIZATION IN PATIENTS WITH MULTIFOCAL CHOROIDITIS: CLINICAL SURVEILLANCE IN PERPETUITY. 61
31725597 2019
32
Visual acuity loss and development of ocular complications in white dot syndromes: a longitudinal analysis of 3 centers. 61
31385033 2019
33
Is subretinal surgery feasible for a non-responsive juxtafoveal type 2 choroidal neovascular membrane? 61
31193243 2019
34
FOVEAL OUTER RETINAL HYPERREFLECTIVITY: A NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDING IN IDIOPATHIC MULTIFOCAL CHOROIDITIS. 61
31274847 2019
35
[Sarcoidosis]. 61
30850198 2019
36
Reclassifying Idiopathic Uveitis: Lessons From a Tertiary Uveitis Center. 61
30352197 2019
37
Imageology features of different types of multifocal choroiditis. 61
30709392 2019
38
Multimodal Imaging of Post-Infectious Unilateral Outer Retinopathy and Choroiditis. 61
29953300 2019
39
Case of cryptococcal choroiditis in adult with T-cell leukemia/lymphoma. 61
30057340 2019
40
Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS. 61
31516733 2019
41
Optical coherence tomography angiography in unilateral multifocal choroiditis and panuveitis: A case report. 61
30681623 2019
42
Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography. 61
30643383 2019
43
Presumed Tuberculous uveitis: clinical features and management. 61
31535701 2019
44
Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients. 61
30153680 2019
45
DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY. 61
28492410 2019
46
Sarcoidosis. 61
30449643 2018
47
Effect of Adjunctive Pars Plana Vitrectomy on Focal Posterior Segment Inflammation: A Case-Control Study in Tuberculosis-Associated Uveitis. 61
31047556 2018
48
Splenic tuberculosis and multifocal serpiginoid choroiditis. 61
28798995 2018
49
IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING. 61
29176533 2018
50
Assessing the Precision of ICD-10 Codes for Uveitis in 2 Electronic Health Record Systems. 61
30054618 2018

Variations for Multifocal Choroiditis

Expression for Multifocal Choroiditis

Search GEO for disease gene expression data for Multifocal Choroiditis.

Pathways for Multifocal Choroiditis

GO Terms for Multifocal Choroiditis

Cellular components related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 TNF IL10 HTRA1 CFH CFB
2 extracellular space GO:0005615 9.02 TNF IL10 HTRA1 CFH CFB

Biological processes related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytokine production GO:0001819 9.49 TNF IL10
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.48 TNF IL10
3 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 TNF IL10
4 negative regulation of mitotic cell cycle GO:0045930 9.43 TNF IL10
5 positive regulation of JAK-STAT cascade GO:0046427 9.4 TNF IL10
6 regulation of synapse organization GO:0050807 9.37 TNF IL10
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 TNF IL10
8 complement activation, alternative pathway GO:0006957 9.26 CFH CFB
9 endothelial cell apoptotic process GO:0072577 9.16 TNF IL10
10 regulation of complement-dependent cytotoxicity GO:1903659 8.96 IL10 CFH
11 negative regulation of cytokine production involved in immune response GO:0002719 8.62 TNF IL10

Sources for Multifocal Choroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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