MCID: MLT035
MIFTS: 32

Multifocal Choroiditis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Multifocal Choroiditis

MalaCards integrated aliases for Multifocal Choroiditis:

Name: Multifocal Choroiditis 52 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 71 C1533060

Summaries for Multifocal Choroiditis

NIH Rare Diseases : 52 Multifocal choroiditis (MFC) is an inflammatory disorder characterized by swelling of the eye (called uveitis ) and multiple lesions in the choroid , a layer of blood vessels between the white of the eye and the retina . Symptoms include blurry vision, floaters , sensitivity to light, blind spots and mild eye discomfort. Though the cause is unknown, multifocal choroiditis is seen most frequently in women ages 20 to 60, and usually affects both eyes. MFC is generally treated with steroid medication that can be taken orally or injected into the eye. Multifocal choroiditis is a chronic condition, thus symptoms may return or worsen even after successful treatment.

MalaCards based summary : Multifocal Choroiditis is related to panuveitis and punctate inner choroidopathy. An important gene associated with Multifocal Choroiditis is ARMS2 (Age-Related Maculopathy Susceptibility 2), and among its related pathways/superpathways are Malaria and Interleukin-10 signaling. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Related Diseases for Multifocal Choroiditis

Diseases related to Multifocal Choroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.7 TNF IL10
2 punctate inner choroidopathy 30.5 TNF IL10
3 histoplasmosis 30.2 TNF CFH ARMS2
4 posterior uveitis 30.1 TNF CFH
5 chorioretinitis 29.9 TNF IL10
6 retinal disease 29.9 CFH CFB ARMS2
7 herpes zoster 29.8 TNF IL10
8 blau syndrome 29.7 TNF IL10
9 exanthem 29.6 TNF IL10
10 sporotrichosis 29.5 TNF IL10
11 cryptococcosis 29.5 TNF IL10
12 typhoid fever 29.5 TNF HTRA1
13 churg-strauss syndrome 29.4 TNF IL10
14 graft-versus-host disease 29.3 TNF IL10
15 hepatitis a 29.2 TNF IL10
16 choroiditis 28.9 TNF IL10 HTRA1 CFH CFB ARMS2
17 macular degeneration, age-related, 1 28.8 TNF HTRA1 CFH CFB ARMS2
18 eye disease 27.2 TNF IL10 HTRA1 CFH CFB ARMS2
19 uveitis 10.4
20 macular retinal edema 10.3
21 retinal detachment 10.2
22 pars planitis 10.2
23 iridocyclitis 10.2
24 central serous chorioretinopathy 10.2 CFH ARMS2
25 bullous retinoschisis 10.2 CFH ARMS2
26 toxic maculopathy 10.2 CFH ARMS2
27 macular degeneration, age-related, 8 10.2 TNF ARMS2
28 fibrosis of extraocular muscles, congenital, 1 10.2
29 angioid streaks 10.2 CFH ARMS2
30 doyne honeycomb retinal dystrophy 10.2 CFH ARMS2
31 atypical hemolytic uremic syndrome with complement gene abnormality 10.2 CFH CFB
32 dense deposit disease 10.2 CFH CFB
33 genetic atypical hemolytic-uremic syndrome 10.2 CFH CFB
34 c3 glomerulopathy 10.2 CFH CFB
35 enterocolitis 10.2 CFH CFB
36 nephrotic syndrome, type 7 10.2 CFH CFB
37 macular degeneration, age-related, 6 10.2 CFH CFB
38 macular degeneration, age-related, 4 10.2 CFH CFB
39 sarcoidosis 1 10.2
40 complement deficiency 10.1 CFH CFB
41 haemophilus influenzae 10.1 TNF CFH
42 acute posterior multifocal placoid pigment epitheliopathy 10.1
43 relapsing fever 10.1 TNF CFH
44 microvascular complications of diabetes 5 10.1
45 myopia 10.1
46 optic nerve disease 10.1
47 ischemia 10.1
48 scotoma 10.1
49 membranoproliferative glomerulonephritis 10.1 CFH CFB
50 melanoma 10.0

Graphical network of the top 20 diseases related to Multifocal Choroiditis:



Diseases related to Multifocal Choroiditis

Symptoms & Phenotypes for Multifocal Choroiditis

Drugs & Therapeutics for Multifocal Choroiditis

Drugs for Multifocal Choroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 3
3 Antineoplastic Agents, Immunological Phase 3
4
tannic acid Approved Phase 2 1401-55-4
5
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
6 Antibodies, Monoclonal Phase 2
7 Antibodies Phase 2
8 Immunologic Factors Phase 2
9 Immunoglobulins Phase 2
10
Fluconazole Approved, Investigational 86386-73-4 3365
11 Endothelial Growth Factors
12 Mitogens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for the Treatment of Neovascular Membranes in Patients With Intraocular Inflammation Completed NCT00407121 Phase 3 Bevacizumab
2 An Open-label Proof-of-concept Study With a Double-masked, Dose-ranging Component to Assess the Effects of AIN457 in Patients With Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
3 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03897192 Bevacizumab
4 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03793400 Bevacizumab Injection
5 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization: Multicenter Collaborative Study Completed NCT00645697

Search NIH Clinical Center for Multifocal Choroiditis

Genetic Tests for Multifocal Choroiditis

Anatomical Context for Multifocal Choroiditis

MalaCards organs/tissues related to Multifocal Choroiditis:

40
Eye, Retina, Endothelial, T Cells, Thyroid, Bone, Kidney

Publications for Multifocal Choroiditis

Articles related to Multifocal Choroiditis:

(show top 50) (show all 332)
# Title Authors PMID Year
1
Differentiating Multifocal Choroiditis and Punctate Inner Choroidopathy: A Cluster Analysis Approach. 61
32027868 2020
2
Long-term Outcome of Zonal Outer Retinopathy in Punctate Inner Choroidopathy or Multifocal Choroiditis. 61
31906767 2020
3
Long-Term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis with Active Choroidal Neovascularization Managed with Intravitreal Bevacizumab. 61
30994378 2020
4
[White dot syndromes : Principles, diagnostics, and treatment]. 61
31748943 2019
5
Masqueraders of multiple evanescent white dot syndrome (MEWDS). 61
31792848 2019
6
Visual acuity loss and development of ocular complications in white dot syndromes: a longitudinal analysis of 3 centers. 61
31385033 2019
7
The Nature and Frequency of Outer Retinal Disruption in Idiopathic Multifocal Choroiditis Associated With Persistent Fundus Hyperautofluorescence. 61
31755966 2019
8
LATE RECURRENCE OF CHOROIDAL NEOVASCULARIZATION IN PATIENTS WITH MULTIFOCAL CHOROIDITIS: CLINICAL SURVEILLANCE IN PERPETUITY. 61
31725597 2019
9
Multifocal Choroiditis Secondary to Acute Zika Virus Infection. 61
31567025 2019
10
Is subretinal surgery feasible for a non-responsive juxtafoveal type 2 choroidal neovascular membrane? 61
31193243 2019
11
FOVEAL OUTER RETINAL HYPERREFLECTIVITY: A NOVEL OPTICAL COHERENCE TOMOGRAPHY FINDING IN IDIOPATHIC MULTIFOCAL CHOROIDITIS. 61
31274847 2019
12
[Sarcoidosis]. 61
30850198 2019
13
Reclassifying Idiopathic Uveitis: Lessons From a Tertiary Uveitis Center. 61
30352197 2019
14
Imageology features of different types of multifocal choroiditis. 61
30709392 2019
15
Multimodal Imaging of Post-Infectious Unilateral Outer Retinopathy and Choroiditis. 61
29953300 2019
16
Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS. 61
31516733 2019
17
Case of cryptococcal choroiditis in adult with T-cell leukemia/lymphoma. 61
30057340 2019
18
Presumed Tuberculous uveitis: clinical features and management. 61
31535701 2019
19
Optical coherence tomography angiography in unilateral multifocal choroiditis and panuveitis: A case report. 61
30681623 2019
20
Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography. 61
30643383 2019
21
DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY. 61
28492410 2019
22
Etiologies and Characteristics of Choroidal Neovascularization in Young Chinese Patients. 61
30153680 2019
23
Sarcoidosis. 61
30449643 2018
24
Effect of Adjunctive Pars Plana Vitrectomy on Focal Posterior Segment Inflammation: A Case-Control Study in Tuberculosis-Associated Uveitis. 61
31047556 2018
25
Splenic tuberculosis and multifocal serpiginoid choroiditis. 61
28798995 2018
26
IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING. 61
29176533 2018
27
Assessing the Precision of ICD-10 Codes for Uveitis in 2 Electronic Health Record Systems. 61
30054618 2018
28
An update on inflammatory choroidal neovascularization: epidemiology, multimodal imaging, and management. 61
30209691 2018
29
Optical coherence tomography angiography and choroidal neovascularization in multifocal choroiditis: A descriptive study. 61
29569477 2018
30
Clinical applications of optical coherence tomography angiography: What we have learnt in the first 3 years. 61
29554812 2018
31
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. 61
30156979 2018
32
Cryptococcal choroiditis in advanced AIDS with clinicopathologic correlation. 61
29780913 2018
33
Clinical Efficacy and Safety of Current Interventions for Choroidal Neovascularization Associated with Rare Diseases: A Systematic Literature Review. 61
29687336 2018
34
An efficacy analysis of anti-vascular endothelial growth factor therapy for choroidal neovascularization secondary to multifocal choroiditis and comparison with wet age-related macular degeneration. 61
29616508 2018
35
Blau Syndrome-Associated Uveitis: Preliminary Results From an International Prospective Interventional Case Series. 61
28887115 2018
36
SPIRONOLACTONE AS A THERAPEUTIC ALTERNATIVE FOR THE BULLOUS VARIANT OF CENTRAL SEROUS CHORIORETINOPATHY. 61
29595560 2018
37
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DISTINGUISH CHOROIDAL NEOVASCULARIZATION FROM MACULAR INFLAMMATORY LESIONS IN MULTIFOCAL CHOROIDITIS. 61
28368976 2018
38
In response to: Parodi MB, Iacono P, Zucchiatti I, et al. Choroidal Neovascularization Associated with Multiple Evanescent White Dot Syndrome Treated with Intravitreal Ranibizumab. 61
28448735 2018
39
Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center. 61
29304271 2018
40
Presumed tuberculosis-associated uveitis: rising incidence and widening criteria for diagnosis in a non-endemic area. 61
28776591 2018
41
Choroidal Neovascularization in Multifocal Choroiditis after Dabrafenib and Trametinib. 61
28777388 2017
42
Multifocal Choroiditis and Panuveitis - difficulties in diagnosis and treatment. 61
29516050 2017
43
A Novel clinical sign in Intraocular Tuberculosis: Active chorioretinitis within chorioretinal atrophy. 61
29152599 2017
44
Multifocal Choroiditis with Peripheral Subretinal Fibrosis and Optic Nerve Involvement. 61
28734337 2017
45
Deep inside Multifocal Choroiditis: an Optical Coherence Tomography Angiography approach. 61
27590527 2017
46
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS. 61
27880741 2017
47
Punctate inner choroidopathy complicated with exudative neurosensory detachment: A favourable response to treatment with systemic corticosteroids and intravitreal ranibizumab. 61
27555066 2017
48
The Value of Diagnostic Work-Up in the Evaluation of White Dot Syndromes. 61
28728181 2017
49
[Sarcoidosis and uveitis : An update]. 61
27904945 2017
50
[Atypical acute syphilitic posterior placoid chorioretinitis]. 61
27461014 2017

Variations for Multifocal Choroiditis

Expression for Multifocal Choroiditis

Search GEO for disease gene expression data for Multifocal Choroiditis.

Pathways for Multifocal Choroiditis

Pathways related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 TNF IL10
2 11.01 TNF IL10
3 10.82 TNF IL10
4 10.78 IL10 CFH CFB
5 10.7 TNF IL10
6 10.42 TNF IL10

GO Terms for Multifocal Choroiditis

Cellular components related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 TNF IL10 HTRA1 CFH CFB
2 extracellular space GO:0005615 9.02 TNF IL10 HTRA1 CFH CFB

Biological processes related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.52 TNF IL10
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.51 TNF IL10
3 negative regulation of mitotic cell cycle GO:0045930 9.49 TNF IL10
4 negative regulation of interleukin-6 production GO:0032715 9.48 TNF IL10
5 positive regulation of JAK-STAT cascade GO:0046427 9.46 TNF IL10
6 regulation of synapse organization GO:0050807 9.43 TNF IL10
7 positive regulation of cytokine secretion GO:0050715 9.4 TNF IL10
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 TNF IL10
9 complement activation, alternative pathway GO:0006957 9.32 CFH CFB
10 endothelial cell apoptotic process GO:0072577 9.26 TNF IL10
11 regulation of complement-dependent cytotoxicity GO:1903659 9.16 IL10 CFH
12 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 TNF IL10
13 receptor biosynthetic process GO:0032800 8.62 TNF IL10

Sources for Multifocal Choroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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