MCID: MLT035
MIFTS: 35

Multifocal Choroiditis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Multifocal Choroiditis

MalaCards integrated aliases for Multifocal Choroiditis:

Name: Multifocal Choroiditis 54 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 74 C1533060

Summaries for Multifocal Choroiditis

NIH Rare Diseases : 54 Multifocal choroiditis (MFC) is an inflammatory disorder characterized by swelling of the eye (called uveitis) and multiple lesions in the choroid, a layer of blood vessels between the white of the eye and the retina. Symptoms include blurry vision, floaters, sensitivity to light, blind spots and mild eye discomfort. Though the cause is unknown, multifocal choroiditis is seen most frequently in women ages 20 to 60, and usually affects both eyes. MFC is generally treated with steroid medication that can be taken orally or injected into the eye. Multifocal choroiditis is a chronic condition, thus symptoms may return or worsen even after successful treatment.        

MalaCards based summary : Multifocal Choroiditis is related to panuveitis and punctate inner choroidopathy. An important gene associated with Multifocal Choroiditis is ARMS2 (Age-Related Maculopathy Susceptibility 2), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Pertussis. The drugs Bevacizumab and Angiogenesis Modulating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone.

Related Diseases for Multifocal Choroiditis

Diseases related to Multifocal Choroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.9 IL10 TNF
2 punctate inner choroidopathy 30.7 IL10 TNF
3 histoplasmosis 30.5 ARMS2 CFH
4 uveitis 30.1 IL10 TNF
5 lyme disease 29.8 CFH TNF
6 reactive arthritis 29.7 IL10 TNF
7 hepatitis a 29.7 IL10 TNF
8 acquired immunodeficiency syndrome 29.5 IL10 TNF
9 choroiditis 29.5 ARMS2 CFB CFH HTRA1 IL10 TNF
10 macular degeneration, age-related, 1 29.1 ARMS2 CFB CFH HTRA1
11 central serous chorioretinopathy 10.3 ARMS2 CFH
12 dense deposit disease 10.2 CFB CFH
13 haemophilus influenzae 10.2 CFH TNF
14 relapsing fever 10.2 CFH TNF
15 enterocolitis 10.2 CFB CFH
16 posterior uveitis 10.2 CFH TNF
17 membranoproliferative glomerulonephritis 10.2 CFB CFH
18 tropical endomyocardial fibrosis 10.1 IL10 TNF
19 endomyocardial fibrosis 10.1 IL10 TNF
20 necrotizing ulcerative gingivitis 10.1 CFB IL10
21 tungiasis 10.1 IL10 TNF
22 transient hypogammaglobulinemia 10.1 IL10 TNF
23 cow milk allergy 10.1 IL10 TNF
24 trichuriasis 10.1 IL10 TNF
25 idiopathic achalasia 10.1 IL10 TNF
26 mucocutaneous leishmaniasis 10.1 IL10 TNF
27 cutaneous leishmaniasis 10.1 IL10 TNF
28 chronic graft versus host disease 10.1 IL10 TNF
29 clonorchiasis 10.1 IL10 TNF
30 trachoma 10.1 IL10 TNF
31 autoimmune gastritis 10.1 IL10 TNF
32 autoimmune disease of eyes, ear, nose and throat 10.1 IL10 TNF
33 intermediate uveitis 10.1 IL10 TNF
34 orofacial granulomatosis 10.1 IL10 TNF
35 transverse myelitis 10.1 IL10 TNF
36 post-transplant lymphoproliferative disease 10.1 IL10 TNF
37 primary systemic mycosis 10.1 IL10 TNF
38 hemolytic uremic syndrome, atypical 1 10.1 CFB CFH
39 mycoplasma pneumoniae pneumonia 10.1 IL10 TNF
40 multidrug-resistant tuberculosis 10.1 IL10 TNF
41 poliomyelitis 10.1 IL10 TNF
42 eales disease 10.1 IL10 TNF
43 coccidiosis 10.1 IL10 TNF
44 hematopoietic stem cell transplantation 10.1 IL10 TNF
45 aseptic meningitis 10.1 IL10 TNF
46 meningitis 10.1 IL10 TNF
47 scrub typhus 10.1 IL10 TNF
48 plasmodium vivax malaria 10.1 IL10 TNF
49 bacterial sepsis 10.1 IL10 TNF
50 lacrimal apparatus disease 10.1 IL10 TNF

Graphical network of the top 20 diseases related to Multifocal Choroiditis:



Diseases related to Multifocal Choroiditis

Symptoms & Phenotypes for Multifocal Choroiditis

Drugs & Therapeutics for Multifocal Choroiditis

Drugs for Multifocal Choroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
2 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2,Not Applicable
3 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
4 Antineoplastic Agents, Immunological Phase 3,Not Applicable
5
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
6
tannic acid Approved Phase 2 1401-55-4
7
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
8
Fluconazole Approved, Investigational 86386-73-4 3365
9 Mitogens
10 Endothelial Growth Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 Long-term Outcome of Zonal Outer Retinopathy in Punctate Inner Choroidopathy or Multifocal Choroiditis Completed NCT03897192 Bevacizumab
5 Long-term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis With Active Choroidal Neovascularization Managed With Anti-vascular Endothelial Growth Factor Completed NCT03793400 Bevacizumab Injection
6 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
7 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Multifocal Choroiditis

Genetic Tests for Multifocal Choroiditis

Anatomical Context for Multifocal Choroiditis

MalaCards organs/tissues related to Multifocal Choroiditis:

42
Eye, Retina, Bone, Endothelial, Bone Marrow, Heart, Lymph Node

Publications for Multifocal Choroiditis

Articles related to Multifocal Choroiditis:

(show top 50) (show all 132)
# Title Authors Year
1
Long-Term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis with Active Choroidal Neovascularization Managed with Intravitreal Bevacizumab. ( 30994378 )
2019
2
Imageology features of different types of multifocal choroiditis. ( 30709392 )
2019
3
Optical coherence tomography angiography in unilateral multifocal choroiditis and panuveitis: A case report. ( 30681623 )
2019
4
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DISTINGUISH CHOROIDAL NEOVASCULARIZATION FROM MACULAR INFLAMMATORY LESIONS IN MULTIFOCAL CHOROIDITIS. ( 28368976 )
2018
5
Optical coherence tomography angiography and choroidal neovascularization in multifocal choroiditis: A descriptive study. ( 29569477 )
2018
6
An efficacy analysis of anti-vascular endothelial growth factor therapy for choroidal neovascularization secondary to multifocal choroiditis and comparison with wet age-related macular degeneration. ( 29616508 )
2018
7
IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING. ( 29176533 )
2018
8
MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS. ( 26967963 )
2017
9
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
10
Multifocal Choroiditis and Panuveitis - difficulties in diagnosis and treatment. ( 29516050 )
2017
11
Multifocal choroiditis as the first sign of systemic sarcoidosis associated with pembrolizumab. ( 29503956 )
2017
12
Choroidal Neovascularization in Multifocal Choroiditis after Dabrafenib and Trametinib. ( 28777388 )
2017
13
Multifocal Choroiditis with Peripheral Subretinal Fibrosis and Optic Nerve Involvement. ( 28734337 )
2017
14
How to Differentiate Myopic Choroidal Neovascularization, Idiopathic Multifocal Choroiditis, and Punctate Inner Choroidopathy Using Clinical and Multimodal Imaging Findings. ( 28297030 )
2017
15
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS. ( 27880741 )
2017
16
Deep inside Multifocal Choroiditis: an Optical Coherence Tomography Angiography approach. ( 27590527 )
2017
17
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. ( 27539089 )
2017
18
CHORIORETINAL WHITE DOT LESIONS IN EYES WITH MULTIFOCAL CHOROIDITIS AND TILTED DISK SYNDROME WITH INFERIOR STAPHYLOMA. ( 27380431 )
2017
19
Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. ( 26951535 )
2016
20
Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26449230 )
2016
21
Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis With Active Lesions. ( 27349415 )
2016
22
Idiopathic Multifocal Choroiditis. ( 27994812 )
2016
23
Course of disease in multifocal choroiditis lacking sufficient immunosuppression: a case report. ( 27776541 )
2016
24
Multifocal choroiditis and panuveitis presenting with progressive equatorial linear streaks: evolution of Schlaegel lines documented with multimodal imaging. ( 25790317 )
2015
25
Sequential Optical Coherence Tomographic Angiography for Diagnosis and Treatment of Choroidal Neovascularization in Multifocal Choroiditis. ( 26111344 )
2015
26
Primary choroidal vitiligo mimicking multifocal choroiditis. ( 26455981 )
2015
27
Erratum to: Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26500039 )
2015
28
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. ( 25687028 )
2015
29
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. ( 25631844 )
2015
30
Idiopathic multifocal choroiditis/punctate inner choroidopathy with acute photoreceptor loss or dysfunction out of proportion to clinically visible lesions. ( 25322466 )
2015
31
Successful treatment of an overlapping choriocapillaritis between multifocal choroiditis and acute zonal occult outer retinopathy (AZOOR) with adalimumab (Humira™). ( 23765682 )
2014
32
Multifocal choroiditis without panuveitis: clinical characteristics and progression. ( 23670288 )
2014
33
Idiopathic multifocal choroiditis with peripapillary zonal inflammation: a multimodal imaging analysis. ( 25372332 )
2014
34
Disseminated histoplasmic multifocal choroiditis in AIDS. ( 24506097 )
2014
35
Idiopathic multifocal choroiditis with outer retinal or chorioretinal atrophy. ( 24378424 )
2014
36
Fundus autofluorescence imaging in multifocal choroiditis: beyond the spots. ( 24329681 )
2014
37
Idiopathic multifocal choroiditis: a comment on present and past nomenclature. ( 23026849 )
2013
38
Intravitreal methotrexate for the treatment of choroidal neovascularization in multifocal choroiditis. ( 23222567 )
2013
39
Multifocal choroiditis following simultaneous hepatitis A, typhoid, and yellow fever vaccination. ( 23439495 )
2013
40
Intravitreal bevacizumab for juxtafoveal choroidal neovascularization secondary to multifocal choroiditis. ( 23503338 )
2013
41
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. ( 23514267 )
2013
42
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. ( 23584703 )
2013
43
A case of multifocal choroiditis secondary to Candida albicans infection in a leukemic child. ( 23617365 )
2013
44
Intravitreal ranibizumab in choroidal neovascularisation due to multifocal choroiditis and panuveitis syndrome. ( 23867878 )
2013
45
Multifocal choroiditis with panuveitis in a patient with disseminated Mycobacterium avium complex. ( 25390811 )
2013
46
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. ( 22954947 )
2012
47
Simultaneous presentation of multifocal choroiditis and acute zonal occult outer retinopathy in one eye. ( 19474000 )
2011
48
Multifocal choroiditis secondary to the reactivation of epstein-barr virus. ( 25390436 )
2011
49
Bilateral angle-closure glaucoma and multifocal choroiditis as a first presentation in hodgkin lymphoma. ( 25390164 )
2011
50
Multifocal choroiditis in a diabetic patient. ( 22454758 )
2011

Variations for Multifocal Choroiditis

Expression for Multifocal Choroiditis

Search GEO for disease gene expression data for Multifocal Choroiditis.

Pathways for Multifocal Choroiditis

GO Terms for Multifocal Choroiditis

Cellular components related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CFB CFH HTRA1 IL10 TNF
2 extracellular space GO:0005615 9.02 CFB CFH HTRA1 IL10 TNF

Biological processes related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.51 IL10 TNF
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.49 IL10 TNF
3 negative regulation of mitotic cell cycle GO:0045930 9.48 IL10 TNF
4 negative regulation of interleukin-6 production GO:0032715 9.46 IL10 TNF
5 positive regulation of cytokine secretion GO:0050715 9.43 IL10 TNF
6 regulation of synapse organization GO:0050807 9.4 IL10 TNF
7 negative regulation of growth of symbiont in host GO:0044130 9.37 IL10 TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 IL10 TNF
9 complement activation, alternative pathway GO:0006957 9.26 CFB CFH
10 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
11 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
12 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Sources for Multifocal Choroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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