MCID: MLT035
MIFTS: 34

Multifocal Choroiditis

Categories: Rare diseases

Aliases & Classifications for Multifocal Choroiditis

MalaCards integrated aliases for Multifocal Choroiditis:

Name: Multifocal Choroiditis 53 73

Classifications:



External Ids:

UMLS 73 C1533060

Summaries for Multifocal Choroiditis

NIH Rare Diseases : 53 Multifocal choroiditis (MFC) is an inflammatory disorder characterized by swelling of the eye (called uveitis) and multiple lesions in the choroid, a layer of blood vessels between the white of the eye and the retina. Symptoms include blurry vision, floaters, sensitivity to light, blind spots and mild eye discomfort. Though the cause is unknown, multifocal choroiditis is seen most frequently in women ages 20 to 60, and usually affects both eyes. MFC is generally treated with steroid medication that can be taken orally or injected into the eye. Multifocal choroiditis is a chronic condition, thus symptoms may return or worsen even after successful treatment.        

MalaCards based summary : Multifocal Choroiditis is related to panuveitis and punctate inner choroidopathy. An important gene associated with Multifocal Choroiditis is CFB (Complement Factor B), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Pertussis. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Related Diseases for Multifocal Choroiditis

Diseases related to Multifocal Choroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.5 IL10 TNF
2 punctate inner choroidopathy 30.3 IL10 TNF
3 lyme disease 29.3 CFH TNF
4 uveitis 29.1 IL10 TNF
5 choroiditis 27.4 ARMS2 CFB CFH HTRA1 IL10 TNF
6 macular degeneration, age-related, 1 27.0 ARMS2 CFB CFH HTRA1 TNF
7 dense deposit disease 10.5 CFB CFH
8 necrotizing ulcerative gingivitis 10.5 CFB IL10
9 enterocolitis 10.5 CFB CFH
10 central serous chorioretinopathy 10.4 ARMS2 CFH
11 membranoproliferative glomerulonephritis 10.4 CFB CFH
12 hemolytic-uremic syndrome 10.3 CFB CFH
13 retinitis 10.0
14 tropical endomyocardial fibrosis 10.0 IL10 TNF
15 microscopic polyangiitis 10.0 IL10 TNF
16 tungiasis 10.0 IL10 TNF
17 endomyocardial fibrosis 10.0 IL10 TNF
18 transient hypogammaglobulinemia 10.0 IL10 TNF
19 idiopathic achalasia 10.0 IL10 TNF
20 trichuriasis 10.0 IL10 TNF
21 haemophilus influenzae 10.0 CFH TNF
22 mucocutaneous leishmaniasis 10.0 IL10 TNF
23 relapsing fever 10.0 CFH TNF
24 histoplasmosis 10.0
25 clonorchiasis 10.0 IL10 TNF
26 trachoma 10.0 IL10 TNF
27 posterior uveitis 10.0 CFH TNF
28 listeriosis 10.0 IL10 TNF
29 transverse myelitis 10.0 IL10 TNF
30 primary systemic mycosis 10.0 IL10 TNF
31 poliomyelitis 10.0 IL10 TNF
32 intermediate uveitis 10.0 IL10 TNF
33 multidrug-resistant tuberculosis 10.0 IL10 TNF
34 orofacial granulomatosis 10.0 IL10 TNF
35 post-transplant lymphoproliferative disease 10.0 IL10 TNF
36 coccidiosis 10.0 IL10 TNF
37 eales disease 10.0 IL10 TNF
38 hemorrhagic fever 10.0 IL10 TNF
39 hematopoietic stem cell transplantation 10.0 IL10 TNF
40 aseptic meningitis 10.0 IL10 TNF
41 scrub typhus 10.0 IL10 TNF
42 cytomegalovirus infection 10.0 IL10 TNF
43 plasmodium vivax malaria 10.0 IL10 TNF
44 q fever 9.9 IL10 TNF
45 lacrimal apparatus disease 9.9 IL10 TNF
46 aphthous stomatitis 9.9 IL10 TNF
47 churg-strauss syndrome 9.9 IL10 TNF
48 severe hemophilia a 9.9 IL10 TNF
49 epstein-barr virus-associated gastric carcinoma 9.9 IL10 TNF
50 lepromatous leprosy 9.9 IL10 TNF

Graphical network of the top 20 diseases related to Multifocal Choroiditis:



Diseases related to Multifocal Choroiditis

Symptoms & Phenotypes for Multifocal Choroiditis

Drugs & Therapeutics for Multifocal Choroiditis

Drugs for Multifocal Choroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2,Not Applicable
4
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
5
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
6 tannic acid Approved, Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
5 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Multifocal Choroiditis

Genetic Tests for Multifocal Choroiditis

Anatomical Context for Multifocal Choroiditis

MalaCards organs/tissues related to Multifocal Choroiditis:

41
Eye, Retina, Endothelial, Bone, Bone Marrow

Publications for Multifocal Choroiditis

Articles related to Multifocal Choroiditis:

(show top 50) (show all 127)
# Title Authors Year
1
Optical coherence tomography angiography and choroidal neovascularization in multifocal choroiditis: A descriptive study. ( 29569477 )
2018
2
MULTIFOCAL CHOROIDAL MELANOMA IN A PATIENT WITH GERM LINE BRCA-ASSOCIATED PROTEIN 1 MUTATION. ( 27749792 )
2018
3
An efficacy analysis of anti-vascular endothelial growth factor therapy for choroidal neovascularization secondary to multifocal choroiditis and comparison with wet age-related macular degeneration. ( 29616508 )
2018
4
Multifocal Choroiditis with Peripheral Subretinal Fibrosis and Optic Nerve Involvement. ( 28734337 )
2017
5
IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING. ( 29176533 )
2017
6
Multifocal choroiditis as the first sign of systemic sarcoidosis associated with pembrolizumab. ( 29503956 )
2017
7
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO DISTINGUISH CHOROIDAL NEOVASCULARIZATION FROM MACULAR INFLAMMATORY LESIONS IN MULTIFOCAL CHOROIDITIS. ( 28368976 )
2017
8
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
9
Choroidal neovascularization in multifocal choroiditis after dabrafenib and trametinib. ( 28777388 )
2017
10
How to Differentiate Myopic Choroidal Neovascularization, Idiopathic Multifocal Choroiditis, and Punctate Inner Choroidopathy Using Clinical and Multimodal Imaging Findings. ( 28297030 )
2017
11
Multifocal Choroiditis and Panuveitis - difficulties in diagnosis and treatment. ( 29516050 )
2017
12
CHORIORETINAL WHITE DOT LESIONS IN EYES WITH MULTIFOCAL CHOROIDITIS AND TILTED DISK SYNDROME WITH INFERIOR STAPHYLOMA. ( 27380431 )
2016
13
Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis. ( 27539089 )
2016
14
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF CHORIORETINAL LESIONS DUE TO IDIOPATHIC MULTIFOCAL CHOROIDITIS. ( 27880741 )
2016
15
MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS. ( 26967963 )
2016
16
Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis With Active Lesions. ( 27349415 )
2016
17
Deep inside Multifocal Choroiditis: an Optical Coherence Tomography Angiography approach. ( 27590527 )
2016
18
Course of disease in multifocal choroiditis lacking sufficient immunosuppression: a case report. ( 27776541 )
2016
19
Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. ( 26951535 )
2016
20
Idiopathic Multifocal Choroiditis. ( 27994812 )
2016
21
Sequential Optical Coherence Tomographic Angiography for Diagnosis and Treatment of Choroidal Neovascularization in Multifocal Choroiditis. ( 26111344 )
2015
22
MULTIFOCAL CHOROIDITIS AND PANUVEITIS PRESENTING WITH PROGRESSIVE EQUATORIAL LINEAR STREAKS: EVOLUTION OF SCHLAEGEL LINES DOCUMENTED WITH MULTIMODAL IMAGING. ( 25790317 )
2015
23
Spectral-domain optical coherence tomographic features of choroidal neovascular membranes in multifocal choroiditis and punctate inner choroidopathy. ( 25631844 )
2015
24
Focal Choroidal Excavation in Multifocal Choroiditis and Punctate Inner Choroidopathy. ( 25687028 )
2015
25
Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis. ( 26449230 )
2015
26
Primary choroidal vitiligo mimicking multifocal choroiditis. ( 26455981 )
2015
27
[Multifocal choroidal ischemia in preeclampsia: report of two cases]. ( 24559529 )
2014
28
IDIOPATHIC MULTIFOCAL CHOROIDITIS/PUNCTATE INNER CHOROIDOPATHY WITH ACUTE PHOTORECEPTOR LOSS OR DYSFUNCTION OUT OF PROPORTION TO CLINICALLY VISIBLE LESIONS. ( 25322466 )
2014
29
Idiopathic multifocal choroiditis with peripapillary zonal inflammation: a multimodal imaging analysis. ( 25372332 )
2014
30
Disseminated histoplasmic multifocal choroiditis in AIDS. ( 24506097 )
2014
31
MULTIFOCAL CHOROIDITIS WITHOUT PANUVEITIS: Clinical Characteristics and Progression. ( 23670288 )
2014
32
Redefining multifocal choroiditis and panuveitis and punctate inner choroidopathy through multimodal imaging. ( 23584703 )
2013
33
Intravitreal bevacizumab for juxtafoveal choroidal neovascularization secondary to multifocal choroiditis. ( 23503338 )
2013
34
Fundus Autofluorescence Imaging in Multifocal Choroiditis: Beyond the Spots. ( 24329681 )
2013
35
Multifocal choroiditis with panuveitis in a patient with disseminated mycobacterium avium complex. ( 25390811 )
2013
36
A case of multifocal choroiditis secondary to Candida albicans infection in a leukemic child. ( 23617365 )
2013
37
Intravitreal ranibizumab in choroidal neovascularisation due to multifocal choroiditis and panuveitis syndrome. ( 23867878 )
2013
38
Intravitreal methotrexate for the treatment of choroidal neovascularization in multifocal choroiditis. ( 23222567 )
2013
39
A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. ( 23514267 )
2013
40
IDIOPATHIC MULTIFOCAL CHOROIDITIS WITH OUTER RETINAL OR CHORIORETINAL ATROPHY. ( 24378424 )
2013
41
Idiopathic multifocal choroiditis: a comment on present and past nomenclature. ( 23026849 )
2013
42
Multifocal choroiditis following simultaneous hepatitis A, typhoid, and yellow fever vaccination. ( 23439495 )
2013
43
Successful treatment of an overlapping choriocapillaritis between multifocal choroiditis and acute zonal occult outer retinopathy (AZOOR) with adalimumab (Humiraa8c). ( 23765682 )
2013
44
Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. ( 22954947 )
2012
45
Multifocal choroid plexus papilloma: a case report. ( 22541786 )
2012
46
Multifocal choroiditis in a diabetic patient. ( 22454758 )
2011
47
Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. ( 21386760 )
2011
48
Multifocal choroiditis secondary to the reactivation of epstein-barr virus. ( 25390436 )
2011
49
Comparison on clinical characteristics of multifocal choroiditis and punctate inner choriodopathy. ( 21913348 )
2011
50
Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. ( 21357402 )
2011

Variations for Multifocal Choroiditis

Expression for Multifocal Choroiditis

Search GEO for disease gene expression data for Multifocal Choroiditis.

Pathways for Multifocal Choroiditis

Pathways related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.36 IL10 TNF
2 11.31 IL10 TNF
3 11.27 IL10 TNF
4 11.06 IL10 TNF
5 11.01 IL10 TNF
6 10.8 IL10 TNF
7 10.7 IL10 TNF
8 10.55 CFB CFH IL10
9 10.43 IL10 TNF

GO Terms for Multifocal Choroiditis

Cellular components related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CFB CFH HTRA1 IL10 TNF
2 extracellular space GO:0005615 9.02 CFB CFH HTRA1 IL10 TNF

Biological processes related to Multifocal Choroiditis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.49 IL10 TNF
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.48 IL10 TNF
3 negative regulation of mitotic cell cycle GO:0045930 9.46 IL10 TNF
4 positive regulation of cytokine secretion GO:0050715 9.43 IL10 TNF
5 negative regulation of interleukin-6 production GO:0032715 9.4 IL10 TNF
6 negative regulation of growth of symbiont in host GO:0044130 9.37 IL10 TNF
7 complement activation, alternative pathway GO:0006957 9.32 CFB CFH
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 IL10 TNF
9 endothelial cell apoptotic process GO:0072577 9.16 IL10 TNF
10 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 IL10 TNF
11 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Sources for Multifocal Choroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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