MMN
MCID: MLT075
MIFTS: 45

Multifocal Motor Neuropathy (MMN)

Categories: Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Multifocal Motor Neuropathy

MalaCards integrated aliases for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 20 53 58 70
Multifocal Motor Neuropathy with Conduction Block 20 58
Mmncb 20 58
Mmn 20 58

Characteristics:

Orphanet epidemiological data:

58
multifocal motor neuropathy
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G61.8
UMLS via Orphanet 71 C0393847
Orphanet 58 ORPHA641
SNOMED-CT via HPO 68 55300003 713514005 82470000
UMLS 70 C0393847

Summaries for Multifocal Motor Neuropathy

GARD : 20 Multifocal motor neuropathy (MMN) causes damage to the nerves in the arms and legs. Nerve damage begins in adulthood and slowly gets worse over time. One side of the body may be more affected than the other. Symptoms of MMN may include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; wrist drop or foot drop, and wasting of the affected muscles. MMN is thought to be due to an abnormal immune response, but the underlying cause is not clear. Diagnosis is based on the symptoms, clinical exam, and specific laboratory testing. Guidelines for diagnosis have been published. Treatment includes intravenous immune globulin (IVIG). Most people with MMN have rapid improvement in weakness with IVIG, but this treatment needs to be repeated regularly. Cyclophosphamide has also been effective in treating MMN. Physical and occupational therapy may be helpful for some people with MMN.

MalaCards based summary : Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and neuropathy. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include cortex and b cells, and related phenotypes are progressive distal muscle weakness and reduced tendon reflexes

NINDS : 53 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia : 73 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 demyelinating polyneuropathy 30.8 FCGR2B CNTN2
2 neuropathy 11.0
3 chronic inflammatory demyelinating polyradiculoneuropathy 10.8
4 polyneuropathy 10.7
5 motor neuron disease 10.7
6 amyotrophic lateral sclerosis 1 10.7
7 lateral sclerosis 10.7
8 polyradiculoneuropathy 10.5
9 lewis-sumner syndrome 10.5
10 muscular atrophy 10.5
11 schizophrenia 10.5
12 guillain-barre syndrome 10.4
13 neuromuscular disease 10.3
14 respiratory failure 10.3
15 progressive muscular atrophy 10.3
16 muscle hypertrophy 10.2
17 axonal neuropathy 10.2
18 acute motor axonal neuropathy 10.2
19 malignant histiocytic disease 10.2 CD1E CD1A
20 central nervous system sarcoma 10.2 CD1E CD1A
21 mycobacterium malmoense 10.2 CD1E CD1A
22 lichen nitidus 10.2 CD1E CD1A
23 predominantly cortical thymoma 10.2 CD1E CD1A
24 mixed type thymoma 10.2 CD1E CD1A
25 encapsulated thymoma 10.2 CD1E CD1A
26 phlyctenulosis 10.2 CD1E CD1A
27 sphenoid sinusitis 10.2 CD1E CD1A
28 chronic laryngitis 10.2 CD1E CD1A
29 tolosa-hunt syndrome 10.2 CD1E CD1A
30 rhinoscleroma 10.2 CD1E CD1A
31 reticulohistiocytic granuloma 10.2 CD1E CD1A
32 epithelial malignant thymoma 10.2 CD1E CD1A
33 inflamed seborrheic keratosis 10.2 CD1E CD1A
34 dendritic cell thymoma 10.2 CD1E CD1A
35 balloon cell malignant melanoma 10.2 CD1E CD1A
36 langerhans cell sarcoma 10.2 CD1E CD1A
37 spongiotic dermatitis 10.2 CD1E CD1A
38 necrobiosis lipoidica 10.2 CD1E CD1A
39 interdigitating dendritic cell sarcoma 10.2 CD1E CD1A
40 diencephalic astrocytoma 10.2 CD1E CD1A
41 orbital cancer 10.2 CD1E CD1A
42 peripheral nervous system disease 10.2
43 b-cell lymphoma 10.2
44 thyroiditis 10.2
45 granuloma annulare 10.2 CD1E CD1A
46 marginal corneal ulcer 10.2 CD1E CD1A
47 oral hairy leukoplakia 10.2 CD1E CD1A
48 histiocytic and dendritic cell cancer 10.2 CD1E CD1A
49 pityriasis rosea 10.2 CD1E CD1A
50 kimura disease 10.2 CD1E CD1A

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to Multifocal Motor Neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Human phenotypes related to Multifocal Motor Neuropathy:

58 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 progressive distal muscle weakness 58 31 hallmark (90%) Very frequent (99-80%) HP:0009063
2 reduced tendon reflexes 58 31 frequent (33%) Frequent (79-30%) HP:0001315
3 fasciculations 58 31 frequent (33%) Frequent (79-30%) HP:0002380
4 limb muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003690
5 functional motor deficit 58 31 frequent (33%) Frequent (79-30%) HP:0004302
6 progressive muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0003323
7 weakness of long finger extensor muscles 58 31 frequent (33%) Frequent (79-30%) HP:0009077
8 muscle spasm 58 31 frequent (33%) Frequent (79-30%) HP:0003394
9 limited wrist extension 58 31 frequent (33%) Frequent (79-30%) HP:0006251
10 increased csf protein 58 31 frequent (33%) Frequent (79-30%) HP:0002922
11 motor conduction block 58 31 frequent (33%) Frequent (79-30%) HP:0012078
12 ganglioside accumulation 31 frequent (33%) HP:0004345
13 abnormality of ganglioside metabolism 58 Frequent (79-30%)

Drugs & Therapeutics for Multifocal Motor Neuropathy

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3
3 Immunologic Factors Phase 3
4 Immunoglobulins, Intravenous Phase 3
5 gamma-Globulins Phase 3
6 Rho(D) Immune Globulin Phase 3
7 Pharmaceutical Solutions Phase 3
8 Immunoglobulin G Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 NPB-01(Intravenous Immunoglobulin) Maintenance Therapy for Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3 NPB-01
2 A Randomized, Double-Blind, Placebo Controlled, Cross-over Study of the Effectiveness of Immune Globulin Intravenous (Human), 10% (IGIV, 10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
3 A European, Randomised, Double-blind, Active Comparator Controlled, Cross-over, Efficacy and Safety Study of a New 10% Ready To-use Liquid Human Intravenous Immunoglobulin (I10E) Versus Kiovig® in Patients With Multifocal Motor Neuropathy Completed NCT01951924 Phase 3 Biological : I10E (Human normal Immunoglobulin for intravenous administration 100mg/mL);Biological: Kiovig® (Human normal Immunoglobulin for intravenous administration 100mg/mL)
4 A Controlled Cross-Over Trial of Subcutaneous Versus Intravenous Immunoglobulin for Multifocal Motor Neuropathy Completed NCT00268788 Phase 2 Subcutaneous immunoglobulin;Intravenous immunoglobulin
5 A Multicentre Study of Subcutaneous Immunoglobulin (SCIG) in Patients With Multifocal Motor Neuropathy (MMN) Completed NCT00701662 Phase 2
6 Randomized, Single-blind, Cross-over Study Investigating the Non-inferiority of Efficacy and Safety of HyQvia in Comparison With Conventional Subcutaneous Ig Therapy in Multifocal Motor Neuropathy Completed NCT02556437 Phase 2 HyQvia;Subcuvia
7 Subcutaneous Immunoglobulin With rHuPH20 in Multifocal Motor Neuropathy Unknown status NCT02885259 rHuPH20
8 Predictive Factors Identification of Long-term Outcome in Multifocal Motor Neuropathy (MMN) Treated With Intravenous Immunoglobulin (IVIG) Completed NCT04015934
9 Effect of Resistance and Aerobic Exercise on Muscle Strength, Aerobic Capacity and Quality of Life in Patients Treated With Immunoglobulin for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Multifocal Motor Neuropathy (MMN) Completed NCT02121678
10 Do (IgG) Variations in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD) and MMN Patients Following Initial Intravenous Immunoglobulin (IVIg) Treatment Correlate With Ultimate Dosing Not yet recruiting NCT04356781

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

40
Cortex, B Cells

Publications for Multifocal Motor Neuropathy

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 780)
# Title Authors PMID Year
1
Multifocal motor neuropathy. 20 61
23623583 2013
2
One nerve suffices: A clinically guided nerve ultrasound protocol for the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS). 61
33355881 2021
3
In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy. 61
33074453 2021
4
Quantitative assessment of brachial plexus MRI for the diagnosis of chronic inflammatory neuropathies. 61
32965512 2021
5
Focal chronic inflammatory demyelinating polyradiculoneuropathy: Onset, course, and distinct features. 61
33660880 2021
6
Long-standing Multifocal Motor Neuropathy Presenting With Delayed Clinical Features of Anti-Myelin-Associated Glycoprotein Neuropathy and Elevated Anti-Myelin-Associated Glycoprotein Antibody Titers. 61
33596002 2021
7
A case of multifocal motor neuropathy after initiation of Ixekizumab for psoriatic arthopathy. 61
33629111 2021
8
A Case of Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodie. 61
33518565 2021
9
Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders. 61
33272955 2021
10
The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. 61
33717213 2021
11
Treatment Approaches for Atypical CIDP. 61
33790853 2021
12
Childhood-Onset Multifocal Motor Neuropathy with IgM Antibodies to Gangliosides GM1: A Case Report with Poor Outcome. 61
33511596 2021
13
High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy. 61
33582569 2021
14
Update on therapy of chronic immune-mediated neuropathies. 61
33452933 2021
15
Pattern of muscle strength improvement after intravenous immunoglobulin therapy in multifocal motor neuropathy. 61
33501670 2021
16
A case of monofocal motor neuropathy with GM1 and GD1b antibodies improved with intravenous immunoglobulin. 61
33279873 2020
17
Difference in distribution of fasciculations between multifocal motor neuropathy and amyotrophic lateral sclerosis. 61
33137570 2020
18
Excitability of motor and sensory axons in multifocal motor neuropathy. 61
32947198 2020
19
Different distributions of nerve demyelination in chronic acquired multifocal polyneuropathies. 61
32947359 2020
20
Clinical outcomes in multifocal motor neuropathy: A combined cross-sectional and follow-up study. 61
32732293 2020
21
Small Fibre Involvement in Multifocal Motor Neuropathy Explored with Sudoscan: A Single-Centre Experience. 61
32993111 2020
22
Nerve Pathology Distinguishes Focal Motor Chronic Inflammatory Demyelinating Polyradiculoneuropathy From Multifocal Motor Neuropathy. 61
32833719 2020
23
Dramatic clinical response to ultra-high dose IVIg in otherwise treatment resistant inflammatory neuropathies. 61
32842835 2020
24
Nerve ultrasound for diagnosing chronic inflammatory neuropathy: A multicenter validation study. 61
32675082 2020
25
Peripheral nerve imaging in amyotrophic lateral sclerosis. 61
32340815 2020
26
Neuromuscular Mimics of Entrapment Neuropathies of Upper Extremities. 61
32020820 2020
27
Immune-Mediated Neuropathies. 61
32703478 2020
28
Electrodiagnostic Testing of Large Fiber Polyneuropathies: A Review of Existing Guidelines. 61
33151658 2020
29
Expanding the Role of the Pharmacist: Immunoglobulin Therapy and Disease Management in Neuromuscular Disorders. 61
32677504 2020
30
Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies-A Case Series. 61
32751486 2020
31
Low interrater reliability of brachial plexus MRI in chronic inflammatory neuropathies. 61
32012299 2020
32
Nerve ultrasound improves detection of treatment-responsive chronic inflammatory neuropathies. 61
31959710 2020
33
Comparison of MRI and motor evoked potential with triple stimulation technique for the detection of brachial plexus abnormalities in multifocal motor neuropathy. 61
31792993 2020
34
Autoimmune Peripheral Neuropathies and Contribution of Antiganglioside/Sulphatide Autoantibody Testing. 61
32411930 2020
35
Multifocal motor neuropathy: controversies and priorities. 61
31511307 2020
36
Impaired conduction of Ia sensory fibers in multifocal motor neuropathy: An electrophysiological demonstration. 61
32913936 2020
37
Childhood-onset multifocal motor neuropathy with IgM antibodies to GM2 and GalNac-GD1a. 61
31522790 2020
38
Patients with chronic autoimmune demyelinating polyneuropathies exhibit cognitive deficits which might be associated with CSF evidence of blood-brain barrier disturbance. 61
32017808 2020
39
Multifocal Motor Neuropathy with Persistent Conduction Block: The Seminal Case. 61
33176310 2020
40
Non-invasive measurement of fasciculation frequency demonstrates diagnostic accuracy in amyotrophic lateral sclerosis. 61
33543131 2020
41
Antiganglioside antibodies in neurological diseases. 61
31726381 2020
42
Preprocessing surface EMG data removes voluntary muscle activity and enhances SPiQE fasciculation analysis. 61
31740273 2020
43
Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies. 61
31827006 2020
44
Autoantibodies in immune-mediated inflammatory neuropathies. 61
31443948 2019
45
Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy. 61
31325017 2019
46
Clinical and functional change in multifocal motor neuropathy treated with IVIg. 61
31416736 2019
47
Randomized trial of facilitated subcutaneous immunoglobulin in multifocal motor neuropathy. 61
31021036 2019
48
Nerve ultrasound can identify treatment-responsive chronic neuropathies without electrodiagnostic features of demyelination. 61
31294858 2019
49
Motor conduction block and conduction velocity in Lewis-Sumner syndrome and multifocal motor neuropathy. 61
31272830 2019
50
Conduction block in immune-mediated neuropathy: paranodopathy versus axonopathy. 61
30882969 2019

Variations for Multifocal Motor Neuropathy

Expression for Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for Multifocal Motor Neuropathy

Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 PTPN22 FCGR2B CD40LG CD1A BLK
2 11.44 PTPN22 CXCL10 CD40LG BLK
3 11.26 FCGR2B CD40LG CD1A

GO Terms for Multifocal Motor Neuropathy

Cellular components related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 FCGR2B CXCL10 CD40LG CD1E CD1A

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.65 FCGR2B CD40LG CD1A
2 response to bacterium GO:0009617 9.54 FCGR2B CXCL10 BANK1
3 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1A
4 regulation of innate immune response GO:0045088 9.43 PTPN22 FCGR2B
5 negative regulation of B cell proliferation GO:0030889 9.4 FCGR2B BLK
6 regulation of B cell receptor signaling pathway GO:0050855 9.32 PTPN22 BLK
7 negative regulation of B cell activation GO:0050869 9.26 FCGR2B BANK1
8 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.16 CD1E CD1A
9 immune response GO:0006955 9.02 FCGR2B CXCL10 CD40LG CD1E CD1A
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.96 CD1E CD1A

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.26 PTPN22 BANK1
2 lipopeptide binding GO:0071723 9.16 CD1E CD1A
3 exogenous lipid antigen binding GO:0030884 8.96 CD1E CD1A
4 endogenous lipid antigen binding GO:0030883 8.62 CD1E CD1A

Sources for Multifocal Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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