MMN
MCID: MLT075
MIFTS: 50

Multifocal Motor Neuropathy (MMN)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Multifocal Motor Neuropathy

MalaCards integrated aliases for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 38 76 53 54 59 73
Multifocal Motor Neuropathy with Conduction Block 53 59
Mmncb 53 59
Mmn 53 59

Characteristics:

Orphanet epidemiological data:

59
multifocal motor neuropathy
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA641
ICD10 via Orphanet 34 G61.8
UMLS via Orphanet 74 C0393847
SNOMED-CT via HPO 69 82470000 55300003 713514005
UMLS 73 C0393847

Summaries for Multifocal Motor Neuropathy

NIH Rare Diseases : 53 Multifocal motor neuropathy (MMN) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). Signs and symptoms may include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; wrist drop or foot drop, and atrophy of affected muscles. MMN is thought to be due to an abnormal immune response, but the underlying cause is not clear. Most people treated with intravenous immune globulin (IVIG) have rapid improvement in weakness, but maintenance IVIG is usually required for sustained improvement.Cyclophosphamide has also been effective in treating MMN. Physical and occupational therapy may be helpful for some people with MMN.

MalaCards based summary : Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and autoimmune disease. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include thyroid, b cells and lung, and related phenotypes are abnormality of ganglioside metabolism and reduced tendon reflexes

NINDS : 54 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia : 76 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 demyelinating polyneuropathy 30.1 CNTN2 FCGR2B
2 autoimmune disease 29.5 CD40LG FCGR2B PTPN22
3 neuropathy 11.1
4 amyotrophic lateral sclerosis 1 10.3
5 lateral sclerosis 10.3
6 polyneuropathy 10.3
7 lewis-sumner syndrome 10.3
8 chronic inflammatory demyelinating polyneuropathy 10.2
9 polyradiculoneuropathy 10.2
10 chronic inflammatory demyelinating polyradiculoneuropathy 10.2
11 muscle hypertrophy 10.2
12 progressive muscular atrophy 10.1
13 thyroiditis 10.1
14 muscular atrophy 10.1
15 mycobacterium malmoense 10.0 CD1A CD1E
16 schizophrenia 10.0
17 ocular motor apraxia 10.0
18 motor neuron disease 10.0
19 respiratory failure 10.0
20 autoimmune disease of peripheral nervous system 10.0 CD1E GLDN
21 discrimination, two-point, reduction in 9.9
22 dysphasia, familial developmental 9.9
23 anxiety 9.9
24 bipolar disorder 9.9
25 hereditary spastic paraplegia 9.9
26 amusia 9.9
27 specific language impairment 9.9
28 reading disorder 9.9
29 epilepsy 9.9
30 neuroma 9.9
31 focal epilepsy 9.9
32 dyslexia 9.9
33 multiple mucosal neuroma 9.9
34 paraplegia 9.9
35 multiple endocrine neoplasia 9.9
36 spondyloarthropathy 1 9.9
37 rheumatoid arthritis 9.9
38 autoimmune disease 1 9.9
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
40 lung cancer susceptibility 3 9.9
41 arthritis 9.9
42 b-cell lymphomas 9.9
43 crohn's disease 9.9
44 ulcerative colitis 9.9
45 restless legs syndrome 9.9
46 lymphoma 9.9
47 colitis 9.9
48 mononeuropathy 9.9
49 adenocarcinoma 9.9
50 spondylitis 9.9

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to Multifocal Motor Neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Human phenotypes related to Multifocal Motor Neuropathy:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of ganglioside metabolism 59 32 frequent (33%) Frequent (79-30%) HP:0004345
2 reduced tendon reflexes 59 32 frequent (33%) Frequent (79-30%) HP:0001315
3 muscle cramps 59 32 frequent (33%) Frequent (79-30%) HP:0003394
4 fasciculations 59 32 frequent (33%) Frequent (79-30%) HP:0002380
5 limb muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003690
6 progressive muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003323
7 increased csf protein 59 32 frequent (33%) Frequent (79-30%) HP:0002922
8 motor conduction block 59 32 frequent (33%) Frequent (79-30%) HP:0012078
9 limited wrist extension 59 32 frequent (33%) Frequent (79-30%) HP:0006251
10 progressive distal muscle weakness 59 32 hallmark (90%) Very frequent (99-80%) HP:0009063
11 weakness of long finger extensor muscles 59 32 frequent (33%) Frequent (79-30%) HP:0009077
12 functional motor problems 59 Frequent (79-30%)
13 functional motor deficit 32 frequent (33%) HP:0004302

Drugs & Therapeutics for Multifocal Motor Neuropathy

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3,Phase 2,Not Applicable
2 Antibodies Phase 3,Phase 2,Not Applicable
3 Immunologic Factors Phase 3,Phase 2,Not Applicable
4 Rho(D) Immune Globulin Phase 3,Phase 2
5 gamma-Globulins Phase 3,Phase 2
6 Immunoglobulins, Intravenous Phase 3,Phase 2
7 Pharmaceutical Solutions Phase 3
8
Iron Approved 7439-89-6 23925

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3 NPB-01
2 Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
3 LIME Study (LFB IVIg MMN Efficacy Study) Completed NCT01951924 Phase 3 Biological : I10E (Human normal Immunoglobulin for intravenous administration 100mg/mL);Biological: Kiovig® (Human normal Immunoglobulin for intravenous administration 100mg/mL)
4 Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN) Completed NCT02556437 Phase 2 HyQvia;Subcuvia
5 Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy Completed NCT00268788 Phase 2 Subcutaneous immunoglobulin;Intravenous immunoglobulin
6 A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN) Completed NCT00701662 Phase 2
7 HyQvia in Multifocal Motor Neuropathy Unknown status NCT02885259 Not Applicable rHuPH20
8 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
9 A Study to Evaluate the Performance of a Diagnostic Test in ALS Unknown status NCT02759913
10 sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN Unknown status NCT02271724
11 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678 Not Applicable
12 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590 Immunoglobulins
13 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
14 Trial Assessing Safety and Efficacy of Gammanorm® in Autoimmune Diseases Recruiting NCT03656640 Gammanorm

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

41
Thyroid, B Cells, Lung, Testes, T Cells

Publications for Multifocal Motor Neuropathy

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 307)
# Title Authors Year
1
Multifocal motor neuropathy following treatment with adalimumab for ulcerative colitis. ( 29767352 )
2018
2
A case of multifocal-motor-neuropathy-like disease with conduction blocks under infliximab with spontaneous progressive recovery. ( 29544914 )
2018
3
A case of acute-onset multifocal motor neuropathy after Mycoplasma infection. ( 29742802 )
2018
4
Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi-center, open-label, 52-week phase 3 trial. ( 29635876 )
2018
5
Intravenous immunoglobulin for treatment of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy in France: are daily practices in accordance with guidelines? ( 30326184 )
2018
6
Multifocal motor neuropathy. ( 30102608 )
2018
7
Multifocal motor neuropathy presenting as a post-infectious complication of dengue: a CASE report. ( 30134860 )
2018
8
Focal neurogenic muscle hypertrophy and fasciculations in multifocal motor neuropathy. ( 30152094 )
2018
9
Multifocal motor neuropathy in Austria: a nationwide survey of clinical features and response to treatment. ( 30259176 )
2018
10
IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: A randomised, double-blind, multi-center cross-over non-inferiority study vs Kiovig®-The LIME Study. ( 30456899 )
2018
11
Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy. ( 30523038 )
2018
12
Immunoglobulin therapy in the treatment of multifocal motor neuropathy. ( 28320129 )
2017
13
High-Dose Subcutaneous Immunoglobulin in Patients With Multifocal Motor Neuropathy: A Nursing Perspective. ( 28885479 )
2017
14
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. ( 27988478 )
2017
15
Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy. ( 28717088 )
2017
16
High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy. ( 28144763 )
2017
17
Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review. ( 28644258 )
2017
18
A comparative study of brachial plexus sonography and magnetic resonance imaging in chronic inflammatory demyelinating neuropathy and multifocal motor neuropathy. ( 28762574 )
2017
19
Teaching Video NeuroImages: Trapezius muscle hypertrophy in multifocal motor neuropathy. ( 28808176 )
2017
20
Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. ( 28837908 )
2017
21
Nerve ultrasound as follow-up tool in treated multifocal motor neuropathy. ( 28681489 )
2017
22
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 27401495 )
2016
23
Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. ( 27796190 )
2016
24
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. ( 27040062 )
2016
25
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. ( 27313890 )
2016
26
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. ( 27396516 )
2016
27
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. ( 27571543 )
2016
28
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. ( 27655303 )
2016
29
Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. ( 27400822 )
2016
30
Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. ( 27130524 )
2016
31
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. ( 27134672 )
2016
32
Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. ( 26991654 )
2016
33
Human immune globulin infusion in the management of multifocal motor neuropathy. ( 30050363 )
2016
34
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. ( 25739040 )
2015
35
Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). ( 26477025 )
2015
36
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. ( 26298317 )
2015
37
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. ( 26280014 )
2015
38
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. ( 25468269 )
2015
39
MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. ( 25736373 )
2015
40
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26218529 )
2015
41
Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 25976871 )
2015
42
The pathogenesis of multifocal motor neuropathy and an update on current management options. ( 25941538 )
2015
43
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. ( 25626722 )
2015
44
Multifocal motor neuropathy: 30 years from onset to diagnosis. ( 26562827 )
2015
45
Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). ( 26329270 )
2015
46
Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. ( 25620065 )
2015
47
Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. ( 25592414 )
2015
48
Multifocal Motor Neuropathy Associated with Infliximab. ( 26223843 )
2015
49
Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26317434 )
2015
50
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. ( 25549972 )
2015

Variations for Multifocal Motor Neuropathy

Expression for Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for Multifocal Motor Neuropathy

Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 BLK CD1A CD40LG FCGR2B PTPN22
2 11.85 BLK CD40LG PTPN22
3 10.93 CD1A CD40LG FCGR2B

GO Terms for Multifocal Motor Neuropathy

Cellular components related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD1A CD1E CD40LG CNTN2

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CD1A CD1E CD40LG FCGR2B
2 regulation of immune response GO:0050776 9.63 CD1A CD40LG FCGR2B
3 positive regulation of T cell mediated cytotoxicity GO:0001916 9.43 CD1A CD1E
4 regulation of innate immune response GO:0045088 9.37 FCGR2B PTPN22
5 regulation of B cell receptor signaling pathway GO:0050855 9.32 BLK PTPN22
6 negative regulation of interleukin-6 secretion GO:1900165 9.26 BANK1 PTPN22
7 negative regulation of B cell activation GO:0050869 9.16 BANK1 FCGR2B
8 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.96 CD1A CD1E
9 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.62 CD1A CD1E

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.26 BANK1 PTPN22
2 lipopeptide binding GO:0071723 9.16 CD1A CD1E
3 endogenous lipid antigen binding GO:0030883 8.96 CD1A CD1E
4 exogenous lipid antigen binding GO:0030884 8.62 CD1A CD1E

Sources for Multifocal Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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