MCID: MLT075
MIFTS: 49

Multifocal Motor Neuropathy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Multifocal Motor Neuropathy

MalaCards integrated aliases for Multifocal Motor Neuropathy:

Name: Multifocal Motor Neuropathy 38 76 53 54 59 73
Multifocal Motor Neuropathy with Conduction Block 53 59
Mmncb 53 59
Mmn 53 59

Characteristics:

Orphanet epidemiological data:

59
multifocal motor neuropathy
Prevalence: 1-9/100000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA641
ICD10 via Orphanet 34 G61.8
UMLS via Orphanet 74 C0393847
SNOMED-CT via HPO 69 82470000 55300003 713514005
UMLS 73 C0393847

Summaries for Multifocal Motor Neuropathy

NIH Rare Diseases : 53 Multifocal motor neuropathy (MMN) is a rare neuropathy characterized by progressive, asymmetric muscle weakness and atrophy (wasting). Signs and symptoms may include weakness in the hands and lower arms; cramping; involuntary contractions or twitching; wrist drop or foot drop, and atrophy of affected muscles. MMN is thought to be due to an abnormal immune response, but the underlying cause is not clear. Most people treated with intravenous immune globulin (IVIG) have rapid improvement in weakness, but maintenance IVIG is usually required for sustained improvement.Cyclophosphamide has also been effective in treating MMN. Physical and occupational therapy may be helpful for some people with MMN.

MalaCards based summary : Multifocal Motor Neuropathy, also known as multifocal motor neuropathy with conduction block, is related to demyelinating polyneuropathy and autoimmune disease. An important gene associated with Multifocal Motor Neuropathy is GLDN (Gliomedin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NF-kappaB Signaling. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include testes, thyroid and b cells, and related phenotypes are progressive distal muscle weakness and reduced tendon reflexes

NINDS : 54 Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly.

Wikipedia : 76 Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the... more...

Related Diseases for Multifocal Motor Neuropathy

Diseases related to Multifocal Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 demyelinating polyneuropathy 30.3 CNTN2 FCGR2B
2 autoimmune disease 29.1 CD40LG FCGR2B PTPN22
3 neuropathy 11.0
4 chronic polyneuropathy 10.3 CD40LG FCGR2B
5 amyotrophic lateral sclerosis 1 10.2
6 lateral sclerosis 10.2
7 autoimmune disease of central nervous system 10.2 CD1E CD40LG
8 polyneuropathy 10.2
9 lewis-sumner syndrome 10.2
10 acute salpingitis 10.1 BLK CD40LG
11 polyradiculoneuropathy 10.1
12 chronic inflammatory demyelinating polyradiculoneuropathy 10.1
13 neuronitis 10.1
14 chronic inflammatory demyelinating polyneuropathy 10.1
15 motor neuron disease 10.1
16 temporal arteritis 10.0 CD40LG PTPN22
17 muscle hypertrophy 10.0
18 progressive muscular atrophy 10.0
19 thyroiditis 10.0
20 muscular atrophy 10.0
21 lymphoma 9.9
22 respiratory failure 9.9
23 cervicitis 9.9
24 mycobacterium malmoense 9.8 CD1A CD1E
25 spondyloarthropathy 1 9.8
26 rheumatoid arthritis 9.8
27 autoimmune disease 1 9.8
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
29 lung cancer susceptibility 3 9.8
30 arthritis 9.8
31 b-cell lymphomas 9.8
32 crohn's disease 9.8
33 ulcerative colitis 9.8
34 restless legs syndrome 9.8
35 colitis 9.8
36 mononeuropathy 9.8
37 adenocarcinoma 9.8
38 spondylitis 9.8
39 axonal neuropathy 9.8
40 amyloidosis 9.8
41 susac syndrome 9.8
42 acute motor axonal neuropathy 9.8
43 bone inflammation disease 9.7 CD40LG PTPN22
44 peripheral nervous system disease 9.5 CD40LG SMN2
45 lupus erythematosus 9.4 BANK1 CD40LG FCGR2B PTPN22
46 systemic lupus erythematosus 8.8 BANK1 BLK CD40LG FCGR2B PTPN22

Graphical network of the top 20 diseases related to Multifocal Motor Neuropathy:



Diseases related to Multifocal Motor Neuropathy

Symptoms & Phenotypes for Multifocal Motor Neuropathy

Human phenotypes related to Multifocal Motor Neuropathy:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 progressive distal muscle weakness 59 32 hallmark (90%) Very frequent (99-80%) HP:0009063
2 reduced tendon reflexes 59 32 frequent (33%) Frequent (79-30%) HP:0001315
3 fasciculations 59 32 frequent (33%) Frequent (79-30%) HP:0002380
4 increased csf protein 59 32 frequent (33%) Frequent (79-30%) HP:0002922
5 progressive muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003323
6 muscle cramps 59 32 frequent (33%) Frequent (79-30%) HP:0003394
7 limb muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003690
8 abnormality of ganglioside metabolism 59 32 frequent (33%) Frequent (79-30%) HP:0004345
9 limited wrist extension 59 32 frequent (33%) Frequent (79-30%) HP:0006251
10 weakness of long finger extensor muscles 59 32 frequent (33%) Frequent (79-30%) HP:0009077
11 motor conduction block 59 32 frequent (33%) Frequent (79-30%) HP:0012078
12 functional motor problems 59 Frequent (79-30%)
13 functional motor deficit 32 frequent (33%) HP:0004302

Drugs & Therapeutics for Multifocal Motor Neuropathy

Drugs for Multifocal Motor Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 3,Phase 2
2 gamma-Globulins Phase 3,Phase 2
3 Pharmaceutical Solutions Phase 3
4 Antibodies Phase 3,Phase 2,Not Applicable
5 Immunoglobulins Phase 3,Phase 2,Not Applicable
6 Immunoglobulins, Intravenous Phase 3,Phase 2
7
Iron Approved 7439-89-6 23925

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3 NPB-01
2 Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
3 LIME Study (LFB IVIg MMN Efficacy Study) Completed NCT01951924 Phase 3 Biological : I10E (Human normal Immunoglobulin for intravenous administration 100mg/mL);Biological: Kiovig® (Human normal Immunoglobulin for intravenous administration 100mg/mL)
4 Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN) Completed NCT02556437 Phase 2 HyQvia;Subcuvia
5 Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy Completed NCT00268788 Phase 2 Subcutaneous immunoglobulin;Intravenous immunoglobulin
6 A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN) Completed NCT00701662 Phase 2
7 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
8 A Study to Evaluate the Performance of a Diagnostic Test in ALS Unknown status NCT02759913
9 sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN Unknown status NCT02271724
10 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678 Not Applicable
11 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590 Immunoglobulins
12 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
13 HyQvia in Multifocal Motor Neuropathy Not yet recruiting NCT02885259 Not Applicable rHuPH20

Search NIH Clinical Center for Multifocal Motor Neuropathy

Genetic Tests for Multifocal Motor Neuropathy

Anatomical Context for Multifocal Motor Neuropathy

MalaCards organs/tissues related to Multifocal Motor Neuropathy:

41
Testes, Thyroid, B Cells, Lung, T Cells

Publications for Multifocal Motor Neuropathy

Articles related to Multifocal Motor Neuropathy:

(show top 50) (show all 297)
# Title Authors Year
1
Multifocal motor neuropathy following treatment with adalimumab for ulcerative colitis. ( 29767352 )
2018
2
A case of multifocal-motor-neuropathy-like disease with conduction blocks under infliximab with spontaneous progressive recovery. ( 29544914 )
2018
3
A case of acute-onset multifocal motor neuropathy after Mycoplasma infection. ( 29742802 )
2018
4
Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi-center, open-label, 52-week phase 3 trial. ( 29635876 )
2018
5
Immunoglobulin therapy in the treatment of multifocal motor neuropathy. ( 28320129 )
2017
6
High-Dose Subcutaneous Immunoglobulin in Patients With Multifocal Motor Neuropathy: A Nursing Perspective. ( 28885479 )
2017
7
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. ( 27988478 )
2017
8
Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy. ( 28717088 )
2017
9
High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy. ( 28144763 )
2017
10
Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review. ( 28644258 )
2017
11
A comparative study of brachial plexus sonography and magnetic resonance imaging in chronic inflammatory demyelinating neuropathy and multifocal motor neuropathy. ( 28762574 )
2017
12
Teaching Video NeuroImages: Trapezius muscle hypertrophy in multifocal motor neuropathy. ( 28808176 )
2017
13
Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. ( 28837908 )
2017
14
Nerve ultrasound as follow-up tool in treated multifocal motor neuropathy. ( 28681489 )
2017
15
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 27401495 )
2016
16
Postoperative Physical Therapy Management of Tendon Transfer for Digital/Wrist Extension Due to Multifocal Motor Neuropathy. ( 27796190 )
2016
17
Cervical root sonography to differentiate multifocal motor neuropathy from ALS. ( 27040062 )
2016
18
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. ( 27313890 )
2016
19
Differential weakness of finger extensor muscles: A clinical pattern of multifocal motor neuropathy. ( 27396516 )
2016
20
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis. ( 27571543 )
2016
21
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. ( 27655303 )
2016
22
Childhood-Onset Multifocal Motor Neuropathy With Immunoglobulin M Antibodies to Gangliosides GM1 and GM2: AA Case Report and Review of the Literature. ( 27400822 )
2016
23
Autoantibody pathogenicity in a multifocal motor neuropathy iPSC-derived model. ( 27130524 )
2016
24
Treatment of patients with multifocal motor neuropathy with immunoglobulins in clinical practice: the SIGNS registry. ( 27134672 )
2016
25
Subcutaneous immunoglobulin for treatment of multifocal motor neuropathy. ( 26991654 )
2016
26
Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. ( 25739040 )
2015
27
Nerve ultrasound in the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis with predominant lower motor neuron disease (ALS/LMND). ( 26477025 )
2015
28
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. ( 26298317 )
2015
29
CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy. ( 26280014 )
2015
30
Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays. ( 25468269 )
2015
31
MRI abnormalities of peripheral nerve and muscle are common in amyotrophic lateral sclerosis and share features with multifocal motor neuropathy. ( 25736373 )
2015
32
Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26218529 )
2015
33
Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 25976871 )
2015
34
The pathogenesis of multifocal motor neuropathy and an update on current management options. ( 25941538 )
2015
35
Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. ( 25626722 )
2015
36
Multifocal motor neuropathy: 30 years from onset to diagnosis. ( 26562827 )
2015
37
Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS(Ac) ). ( 26329270 )
2015
38
Nerve ultrasound in a case of multifocal motor neuropathy without conduction block. ( 25620065 )
2015
39
Multifocal-motor-neuropathy-like disease associated with Infliximab treatment in a patient with Crohn's disease. ( 25592414 )
2015
40
Multifocal Motor Neuropathy Associated with Infliximab. ( 26223843 )
2015
41
Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. ( 26317434 )
2015
42
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study. ( 25549972 )
2015
43
Practical rules for electrodiagnosis in suspected multifocal motor neuropathy. ( 25695919 )
2015
44
Complement activity is associated with disease severity in multifocal motor neuropathy. ( 26161430 )
2015
45
Treatment of multifocal motor neuropathy. ( 24395647 )
2014
46
The node of Ranvier in multifocal motor neuropathy. ( 24801202 )
2014
47
Immunoglobulin (Ig) in multifocal motor neuropathy (MMN): update on evidence for Ig treatment in MMN. ( 25546756 )
2014
48
Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy. ( 25181830 )
2014
49
Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. ( 25283719 )
2014
50
Treatment of multifocal motor neuropathy with intravenous immunoglobulin. ( 24699885 )
2014

Variations for Multifocal Motor Neuropathy

Expression for Multifocal Motor Neuropathy

Search GEO for disease gene expression data for Multifocal Motor Neuropathy.

Pathways for Multifocal Motor Neuropathy

Pathways related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 BLK CD1A CD40LG FCGR2B PTPN22
2 11.85 BLK CD40LG PTPN22
3 10.93 CD1A CD40LG FCGR2B

GO Terms for Multifocal Motor Neuropathy

Cellular components related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 CD1A CD1E CD40LG CNTN2 FCGR2B

Biological processes related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 CD1A CD1E CD40LG FCGR2B
2 regulation of immune response GO:0050776 9.58 CD1A CD40LG FCGR2B
3 T cell differentiation GO:0030217 9.43 BLK PTPN22
4 regulation of innate immune response GO:0045088 9.32 FCGR2B PTPN22
5 regulation of B cell receptor signaling pathway GO:0050855 9.26 BLK PTPN22
6 negative regulation of B cell activation GO:0050869 9.16 BANK1 FCGR2B
7 negative regulation of interleukin-6 secretion GO:1900165 8.96 BANK1 PTPN22
8 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.62 CD1A CD1E

Molecular functions related to Multifocal Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.32 BANK1 PTPN22
2 beta-2-microglobulin binding GO:0030881 9.26 CD1A CD1E
3 lipopeptide binding GO:0071723 9.16 CD1A CD1E
4 exogenous lipid antigen binding GO:0030884 8.96 CD1A CD1E
5 endogenous lipid antigen binding GO:0030883 8.62 CD1A CD1E

Sources for Multifocal Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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