MCID: MLT017
MIFTS: 26

Multifocal Osteogenic Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Multifocal Osteogenic Sarcoma

MalaCards integrated aliases for Multifocal Osteogenic Sarcoma:

Name: Multifocal Osteogenic Sarcoma 12 15
Multifocal Osteosarcoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3360
NCIt 50 C6470
SNOMED-CT 67 431371000124105
UMLS 70 C1334820

Summaries for Multifocal Osteogenic Sarcoma

MalaCards based summary : Multifocal Osteogenic Sarcoma, also known as multifocal osteosarcoma, is related to synchronous multifocal osteogenic sarcoma and asynchronous multifocal osteogenic sarcoma. An important gene associated with Multifocal Osteogenic Sarcoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell adhesion molecules and Direct p53 effectors. Affiliated tissues include thyroid, and related phenotypes are integument and neoplasm

Related Diseases for Multifocal Osteogenic Sarcoma

Diseases in the Multifocal Osteogenic Sarcoma family:

Asynchronous Multifocal Osteogenic Sarcoma

Diseases related to Multifocal Osteogenic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 synchronous multifocal osteogenic sarcoma 11.3
2 asynchronous multifocal osteogenic sarcoma 11.3
3 osteogenic sarcoma 10.5
4 sarcoma 10.3
5 spindle cell sarcoma 10.3
6 benign pleural mesothelioma 10.1 TP53 CD34
7 pediatric angiosarcoma 10.1 TP53 CD34
8 angiosarcoma 10.1 TP53 CD34
9 pediatric liposarcoma 10.1 TP53 CD34
10 liposarcoma 10.1 TP53 CD34
11 breast hemangioma 10.1 TP53 CD34
12 breast sarcoma 10.1 TP53 CD34
13 breast malignant phyllodes tumor 10.1 TP53 CD34
14 cervical adenosarcoma 10.1 TP53 CD34
15 gliofibroma 10.1 TP53 CD34
16 neurofibrosarcoma 10.1 TP53 CD34
17 vulvar disease 10.1 TP53 CD34
18 vulvar dystrophy 10.1 TP53 CD34
19 sweat gland benign neoplasm 10.1 TP53 CD34
20 liver benign neoplasm 10.1 TP53 CD34
21 thoracic benign neoplasm 10.1 TP53 CD34
22 breast benign neoplasm 10.1 TP53 CD34
23 mixed cell type cancer 10.1 TP53 CD34
24 respiratory system benign neoplasm 10.1 TP53 CD34
25 glomus tumor 10.1 TP53 CD34
26 mesenchymal cell neoplasm 10.1 TP53 CD34
27 connective tissue benign neoplasm 10.1 TP53 CD34
28 uterine benign neoplasm 10.1 TP53 CD34
29 reproductive organ benign neoplasm 10.1 TP53 CD34
30 central nervous system benign neoplasm 10.1 TP53 CD34
31 myeloproliferative syndrome, transient 10.1 TP53 CD34
32 well-differentiated liposarcoma 10.0 TP53 CD34
33 fasciitis 10.0 TP53 CD34
34 vascular cancer 10.0 TP53 CD34
35 skeletal muscle cancer 10.0 TP53 CD34
36 muscle cancer 10.0 TP53 CD34
37 myxofibrosarcoma 10.0 TP53 CD34
38 cardiovascular organ benign neoplasm 10.0 TP53 CD34
39 germ cell and embryonal cancer 10.0 TP53 CD34
40 lymphangioma 10.0 TP53 CD34
41 neurofibroma 10.0 TP53 CD34
42 childhood malignant schwannoma 10.0 TP53 SPP1
43 benign peritoneal mesothelioma 10.0 SPP1 CD34
44 li-fraumeni syndrome 10.0
45 mammary paget's disease 10.0
46 dedifferentiated liposarcoma 10.0 TP53 CD34
47 inflammatory myofibroblastic tumor 10.0 TP53 CD34
48 myoma 10.0 TP53 CD34
49 dermatofibrosarcoma protuberans 10.0 TP53 CD34
50 fibrous dysplasia 10.0 TP53 SPP1

Graphical network of the top 20 diseases related to Multifocal Osteogenic Sarcoma:



Diseases related to Multifocal Osteogenic Sarcoma

Symptoms & Phenotypes for Multifocal Osteogenic Sarcoma

MGI Mouse Phenotypes related to Multifocal Osteogenic Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 CD34 PTPRC SPP1 TP53
2 neoplasm MP:0002006 8.92 CD34 PTPRC SPP1 TP53

Drugs & Therapeutics for Multifocal Osteogenic Sarcoma

Search Clinical Trials , NIH Clinical Center for Multifocal Osteogenic Sarcoma

Genetic Tests for Multifocal Osteogenic Sarcoma

Anatomical Context for Multifocal Osteogenic Sarcoma

MalaCards organs/tissues related to Multifocal Osteogenic Sarcoma:

40
Thyroid

Publications for Multifocal Osteogenic Sarcoma

Articles related to Multifocal Osteogenic Sarcoma:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Multifocal Osteosarcoma: Multiple Primaries or Metastases? A Report of Rare Case and Review of Literature. 61
33708722 2020
2
Diffuse Increased 68Ga-DOTATATE But Unimpressive 18F-FDG Osseous Activity in a Patient With Rapid-Progressing Synchronous Multifocal Osteosarcoma. 61
32796243 2020
3
Alpha-Particle Therapy for Multifocal Osteosarcoma: A Hypothesis. 61
32073902 2020
4
[Synchronous multicentric osteosarcoma: treatment and prognostic factor analysis]. 61
31607017 2019
5
Secondary multifocal osteosarcoma developing on the background of bone infarct. 61
28473435 2017
6
Multifocal Osteosarcoma: Unusual Presentation and Imaging Findings. 61
28166155 2017
7
Preliminary Application of Precision Genomic Medicine Detecting Gene Variation in Patients with Multifocal Osteosarcoma. 61
27384721 2016
8
Synchronous multifocal osteogenic sarcoma on multimodality imaging including bone scintigraphy. 61
25210291 2014
9
Proteomic identification of 14-3-3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. 61
24536031 2014
10
Multifocal osteosarcoma of the skull: multiple primary or metastatic? A case report. 61
24868228 2014
11
Synchronous multifocal osteosarcoma with hypocalcemia. 61
23463848 2013
12
Synchronous multifocal osteosarcoma involving the skull presenting with intracranial hemorrhage -case report-. 61
20505300 2010
13
Multifocal osteosarcoma in childhood. 61
19711159 2009
14
Osteosarcoma: review of the past, impact on the future. The American experience. 61
20213394 2009
15
Hypocalcemia as a presentation for multifocal osteosarcoma. 61
17274007 2008
16
Surgical images: musculoskeletal Synchronous multifocal osteosarcoma. 61
17550718 2007
17
Treatment and prognosis for synchronous multifocal osteosarcoma in 42 patients. 61
16877608 2006
18
Synchronous multifocal osteosarcoma: report of one case. 61
17078469 2006
19
Multifocal osteosarcoma involving unusual sites. 61
16809155 2006
20
Synchronous multifocal osteosarcoma: case report and literature review. 61
17251658 2006
21
Diffuse calcification of metastases after intensive multiagent chemotherapy in widespread osteosarcoma leading to death in a 18-year-old male: report of a case and literature review. 61
17303903 2006
22
Seeding of osteosarcoma in the biopsy tract of a patient with multifocal osteosarcoma. 61
15756542 2005
23
Prenatal diagnosis in Li-Fraumeni syndrome. 61
15342977 2004
24
Primary vertebral osteosarcoma: imaging findings. 61
14749514 2004
25
Renal involvement in multifocal osteosarcoma. 61
11966600 2002
26
Metachronous multifocal osteosarcoma: a case report and literature review. 61
11814757 2002
27
Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report. 61
11773266 2001
28
Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases. 61
11450892 2001
29
[Multifocal osteosarcoma. A case report]. 61
11075263 2000
30
Multifocal osteogenic sarcoma in Paget's disease. 61
10929418 2000
31
Osteosarcomatosis involving craniofacial bones presenting with cranial nerve palsies. 61
10829114 2000
32
Multifocal osteosarcoma as second tumor after childhood retinoblastoma. 61
10478625 1999
33
Multifocal osteosarcoma following retinoblastoma. 61
10415462 1999
34
Multifocal osteosarcoma: an unusual presentation. 61
10029815 1999
35
Bifocal sclerosing osteosarcoma: unusual presentation and course. 61
9765139 1998
36
Malignant tumors of the osteogenic matrix. 61
9652509 1998
37
Miliary osteosarcomatosis with associated hypocalcemia. 61
9345337 1997
38
Second malignant neoplasms occuring in survivors of osteosarcoma. 61
9307198 1997
39
Multifocal osteosarcoma in a patient with Fanconi anemia. 61
9201150 1997
40
Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones. 61
8922204 1996
41
[Second tumors in pediatric oncologic patients. Report of 5 cases]. 61
7569549 1995
42
Germline p53 gene mutations in subsets of glioma patients. 61
8308926 1994
43
Multifocal osteogenic sarcoma of the skull in a patient who had congenital hyperphosphatasemic skeletal dysplasia. A case report. 61
1325972 1992
44
Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma. 61
1349175 1992
45
Multifocal osteosarcoma with extensive pleural metastatic disease. 61
1520177 1992
46
Sarcoma in Paget disease of bone: clinical, radiologic, and pathologic features in 22 cases. 61
2028867 1991
47
Case report 703: Multifocal osteosarcoma. 61
1776033 1991
48
"Don't bump my bed, don't touch my feet!". 61
2574981 1989
49
Postradiation multicentric osteosarcoma. 61
3164232 1988
50
Focal and multifocal osteosarcoma in two foals. 61
3464422 1986

Variations for Multifocal Osteogenic Sarcoma

Expression for Multifocal Osteogenic Sarcoma

Search GEO for disease gene expression data for Multifocal Osteogenic Sarcoma.

Pathways for Multifocal Osteogenic Sarcoma

GO Terms for Multifocal Osteogenic Sarcoma

Cellular components related to Multifocal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 PTPRC CD34

Biological processes related to Multifocal Osteogenic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell cycle GO:0051726 9.37 TP53 PTPRC
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.32 TP53 PTPRC
3 hematopoietic progenitor cell differentiation GO:0002244 9.26 TP53 PTPRC
4 negative regulation of interleukin-2 production GO:0032703 9.16 PTPRC CD34
5 response to gamma radiation GO:0010332 8.96 TP53 PTPRC
6 bone marrow development GO:0048539 8.62 TP53 PTPRC

Sources for Multifocal Osteogenic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....