MCID: MLT003
MIFTS: 32

Multilocular Clear Cell Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards integrated aliases for Multilocular Clear Cell Renal Cell Carcinoma:

Name: Multilocular Clear Cell Renal Cell Carcinoma 12 15
Cystadenocarcinoma of Kidney 12 70
Renal Cystadenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4463
NCIt 50 C4524
SNOMED-CT 67 254916002
UMLS 70 C0346249

Summaries for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards based summary : Multilocular Clear Cell Renal Cell Carcinoma, also known as cystadenocarcinoma of kidney, is related to birt-hogg-dube syndrome and multilocular cystic renal neoplasm of low malignant potential, and has symptoms including flank pain An important gene associated with Multilocular Clear Cell Renal Cell Carcinoma is FLCN (Folliculin), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and PI3K / Akt Signaling. Affiliated tissues include kidney, and related phenotype is neoplasm.

Related Diseases for Multilocular Clear Cell Renal Cell Carcinoma

Graphical network of the top 20 diseases related to Multilocular Clear Cell Renal Cell Carcinoma:



Diseases related to Multilocular Clear Cell Renal Cell Carcinoma

Symptoms & Phenotypes for Multilocular Clear Cell Renal Cell Carcinoma

UMLS symptoms related to Multilocular Clear Cell Renal Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Multilocular Clear Cell Renal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 FLCN FNIP1 FNIP2 TSC2

Drugs & Therapeutics for Multilocular Clear Cell Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Multilocular Clear Cell Renal Cell Carcinoma

Genetic Tests for Multilocular Clear Cell Renal Cell Carcinoma

Anatomical Context for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards organs/tissues related to Multilocular Clear Cell Renal Cell Carcinoma:

40
Kidney

Publications for Multilocular Clear Cell Renal Cell Carcinoma

Articles related to Multilocular Clear Cell Renal Cell Carcinoma:

# Title Authors PMID Year
1
Successful partial nephrectomy of a T1b multilocular clear cell renal cell carcinoma arising in a renal graft. 61
30345224 2019
2
Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman. 61
23798872 2013
3
[Multiphasic spiral CT scanning features in 100 patients with small renal cell carcinoma]. 61
17892138 2007

Variations for Multilocular Clear Cell Renal Cell Carcinoma

Cosmic variations for Multilocular Clear Cell Renal Cell Carcinoma:

9 (show top 50) (show all 6488)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM143616890 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.2108A>C p.Q703P 2:184937759-184937759 3
2 COSM88579140 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.2363A>C p.Q788P 2:184937759-184937759 3
3 COSM88566796 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.121G>C p.E41Q 2:184866378-184866378 3
4 COSM143612455 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.-135G>C p.? 2:184866378-184866378 3
5 COSM100952565 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 3
6 COSM100946000 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 3
7 COSM85796182 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 3
8 COSM144685741 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 3
9 COSM131496685 ZNF521 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3298A>G p.S1100G 18:25224620-25224620 3
10 COSM94790253 ZNF521 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3298A>G p.S1100G 18:25224620-25224620 3
11 COSM140713700 ZNF521 kidney,NS,carcinoma,clear cell renal cell carcinoma c.2638A>G p.S880G 18:25224620-25224620 3
12 COSM84285389 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3559G>A p.V1187I 16:49626188-49626188 3
13 COSM132161238 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3208G>A p.V1070I 16:49626188-49626188 3
14 COSM136721462 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3379G>A p.V1127I 16:49626188-49626188 3
15 COSM136000826 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3379G>A p.V1127I 16:49626188-49626188 3
16 COSM137730910 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3208G>A p.V1070I 16:49626188-49626188 3
17 COSM137390699 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3559G>A p.V1187I 16:49626188-49626188 3
18 COSM137183617 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3379G>A p.V1127I 16:49626188-49626188 3
19 COSM149268221 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.745G>A p.G249S 16:72959401-72959401 3
20 COSM102022298 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.4310G>A p.C1437Y 16:72795630-72795630 3
21 COSM102022947 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.-23-8436G>A p.? 16:72959401-72959401 3
22 COSM87274133 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.745G>A p.G249S 16:72959401-72959401 3
23 COSM87273419 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.7052G>A p.C2351Y 16:72795630-72795630 3
24 COSM149266502 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.7052G>A p.C2351Y 16:72795630-72795630 3
25 COSM152022098 YES1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1069T>A p.L357I 18:739803-739803 3
26 COSM89895108 YES1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1069T>A p.L357I 18:739803-739803 3
27 COSM136836927 YES1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1084T>A p.L362I 18:739803-739803 3
28 COSM133267864 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
29 COSM143036610 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
30 COSM145023517 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
31 COSM127993611 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
32 COSM90943050 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
33 COSM126968507 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.-161C>G p.? 11:102114196-102114196 3
34 COSM85232102 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
35 COSM128447153 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 3
36 COSM94289984 XIAP kidney,NS,carcinoma,clear cell renal cell carcinoma c.1001A>T p.K334M 23:123891261-123891261 3
37 COSM108083403 XIAP kidney,NS,carcinoma,clear cell renal cell carcinoma c.1001A>T p.K334M 23:123891261-123891261 3
38 COSM92180300 XIAP kidney,NS,carcinoma,clear cell renal cell carcinoma c.1001A>T p.K334M 23:123891261-123891261 3
39 COSM108082894 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
40 COSM92179769 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
41 COSM94289415 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
42 COSM137057201 WWP2 kidney,NS,carcinoma,clear cell renal cell carcinoma c.739G>C p.E247Q 16:69936391-69936391 3
43 COSM96278984 WWP2 kidney,NS,carcinoma,clear cell renal cell carcinoma c.2056G>C p.E686Q 16:69936391-69936391 3
44 COSM92965606 WWP2 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1708G>C p.E570Q 16:69936391-69936391 3
45 COSM149735880 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.536C>A p.P179H 11:32434810-32434810 3
46 COSM91370315 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1432+1G>C p.? 11:32391971-32391971 3
47 COSM113481676 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.536C>A p.P179H 11:32434810-32434810 3
48 COSM111527817 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1372+10G>C p.? 11:32391971-32391971 3
49 COSM130509133 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.745+1G>C p.? 11:32391971-32391971 3
50 COSM148578314 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1423+10G>C p.? 11:32391971-32391971 3

Expression for Multilocular Clear Cell Renal Cell Carcinoma

Search GEO for disease gene expression data for Multilocular Clear Cell Renal Cell Carcinoma.

Pathways for Multilocular Clear Cell Renal Cell Carcinoma

Pathways related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 TSC2 FNIP2 FNIP1 FLCN
2 10.92 TSC2 FNIP2

GO Terms for Multilocular Clear Cell Renal Cell Carcinoma

Cellular components related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.35 RILP GLMP FNIP2 FNIP1 FLCN
2 lysosome GO:0005764 9.1 TSC2 RILP GLMP FNIP2 FNIP1 FLCN

Biological processes related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.48 FNIP2 FNIP1
2 cellular response to starvation GO:0009267 9.46 FNIP1 FLCN
3 negative regulation of protein kinase B signaling GO:0051898 9.43 TSC2 FLCN
4 regulation of protein phosphorylation GO:0001932 9.43 FNIP2 FNIP1 FLCN
5 positive regulation of protein complex assembly GO:0031334 9.4 FNIP2 FNIP1
6 positive regulation of TOR signaling GO:0032008 9.37 FNIP1 FLCN
7 TOR signaling GO:0031929 9.32 FNIP1 FLCN
8 negative regulation of mitochondrion organization GO:0010823 9.16 FNIP1 FLCN
9 regulation of pro-B cell differentiation GO:2000973 8.96 FNIP1 FLCN
10 negative regulation of TOR signaling GO:0032007 8.8 TSC2 FNIP1 FLCN

Molecular functions related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.96 FNIP2 FNIP1
2 ATPase inhibitor activity GO:0042030 8.62 FNIP2 FNIP1

Sources for Multilocular Clear Cell Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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