MCID: MLT003
MIFTS: 30

Multilocular Clear Cell Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards integrated aliases for Multilocular Clear Cell Renal Cell Carcinoma:

Name: Multilocular Clear Cell Renal Cell Carcinoma 12 15
Cystadenocarcinoma of Kidney 12 73
Renal Cystadenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4463
NCIt 50 C4524
UMLS 73 C0346249

Summaries for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards based summary : Multilocular Clear Cell Renal Cell Carcinoma, also known as cystadenocarcinoma of kidney, is related to multilocular cystic renal neoplasm of low malignant potential and cystadenocarcinoma, and has symptoms including flank pain An important gene associated with Multilocular Clear Cell Renal Cell Carcinoma is FLCN (Folliculin), and among its related pathways/superpathways are Akt Signaling and Glucose / Energy Metabolism. Affiliated tissues include kidney, liver and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Multilocular Clear Cell Renal Cell Carcinoma

Graphical network of the top 20 diseases related to Multilocular Clear Cell Renal Cell Carcinoma:



Diseases related to Multilocular Clear Cell Renal Cell Carcinoma

Symptoms & Phenotypes for Multilocular Clear Cell Renal Cell Carcinoma

UMLS symptoms related to Multilocular Clear Cell Renal Cell Carcinoma:


flank pain

MGI Mouse Phenotypes related to Multilocular Clear Cell Renal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 FLCN SLC2A4 TGFB2 TGFB3 TSC2
2 cellular MP:0005384 9.63 C1QBP FLCN SLC2A4 TGFB2 TGFB3 TSC2
3 embryo MP:0005380 9.35 C1QBP FLCN TGFB2 TGFB3 TSC2
4 growth/size/body region MP:0005378 9.1 C1QBP FLCN SLC2A4 TGFB2 TGFB3 TSC2

Drugs & Therapeutics for Multilocular Clear Cell Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Multilocular Clear Cell Renal Cell Carcinoma

Genetic Tests for Multilocular Clear Cell Renal Cell Carcinoma

Anatomical Context for Multilocular Clear Cell Renal Cell Carcinoma

MalaCards organs/tissues related to Multilocular Clear Cell Renal Cell Carcinoma:

41
Kidney, Liver, Heart, Tongue

Publications for Multilocular Clear Cell Renal Cell Carcinoma

Articles related to Multilocular Clear Cell Renal Cell Carcinoma:

# Title Authors Year
1
Successful partial nephrectomy of a T1b multilocular clear cell renal cell carcinoma arising in a renal graft. ( 30345224 )
2019

Variations for Multilocular Clear Cell Renal Cell Carcinoma

Cosmic variations for Multilocular Clear Cell Renal Cell Carcinoma:

9 (show top 50) (show all 2131)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM249350 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.2363A>C p.Q788P 2:184937759-184937759 5
2 COSM249389 ZNF804A kidney,NS,carcinoma,clear cell renal cell carcinoma c.121G>C p.E41Q 2:184866378-184866378 5
3 COSM249348 ZNF800 kidney,NS,carcinoma,clear cell renal cell carcinoma c.719A>G p.N240S 7:127374617-127374617 5
4 COSM249454 ZNF521 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3298A>G p.S1100G 18:25224620-25224620 5
5 COSM30510 ZNF423 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3559G>A p.V1187I 16:49626188-49626188 5
6 COSM6970086 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.7052G>A p.C2351Y 16:72795630-72795630 5
7 COSM3276983 ZFHX3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.745G>A p.G249S 16:72959401-72959401 5
8 COSM6961023 YES1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1069T>A p.L357I 18:739803-739803 5
9 COSM6935891 YAP1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.374C>G p.A125G 11:102114196-102114196 5
10 COSM6946890 XIAP kidney,NS,carcinoma,clear cell renal cell carcinoma c.1001A>T p.K334M 23:123891261-123891261 5
11 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma c.563G>C p.G188A 23:123886225-123886225 5
12 COSM249421 WWP2 kidney,NS,carcinoma,clear cell renal cell carcinoma c.2056G>C p.E686Q 16:69936391-69936391 5
13 COSM1272065 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.332C>A p.P111H 11:32434810-32434810 5
14 COSM6201648 WT1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1228+1G>C p.? 11:32391971-32391971 5
15 COSM20759 WNK3 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3809C>A p.T1270N 23:54238942-54238942 5
16 COSM249385 VWA8 kidney,NS,carcinoma,clear cell renal cell carcinoma c.1286A>G p.Q429R 13:41865963-41865963 5
17 COSM249519 VWA8 kidney,NS,carcinoma,clear cell renal cell carcinoma c.3300A>T p.E1100D 13:41701456-41701456 5
18 COSM6930635 VTCN1 kidney,NS,carcinoma,clear cell renal cell carcinoma c.98-1G>T p.? 1:117156922-117156922 5
19 COSM26611 VPS13B kidney,NS,carcinoma,clear cell renal cell carcinoma c.2580C>T p.Y860Y 8:99274262-99274262 5
20 COSM17855 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.233A>G p.N78S 3:10142080-10142080 5
21 COSM18024 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.598C>T p.R200W 3:10149921-10149921 5
22 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma c.353T>C p.L118P 3:10146526-10146526 5
23 COSM30224 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.326T>G p.I109S 3:10142173-10142173 5
24 COSM14375 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.343C>T p.H115Y 3:10146516-10146516 5
25 COSM14311 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.499C>T p.R167W 3:10149822-10149822 5
26 COSM18152 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.463G>A p.V155M 3:10146636-10146636 5
27 COSM17715 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.221T>A p.V74D 3:10142068-10142068 5
28 COSM18074 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.193T>C p.S65P 3:10142040-10142040 5
29 COSM25682 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.430G>T p.G144* 3:10146603-10146603 5
30 COSM249129 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.163G>T p.E55* 3:10142010-10142010 5
31 COSM18069 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.407T>A p.F136Y 3:10146580-10146580 5
32 COSM18192 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.350G>T p.W117L 3:10146523-10146523 5
33 COSM97092 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.241C>A p.P81T 3:10142088-10142088 5
34 COSM1731995 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.328C>A p.H110N 3:10142175-10142175 5
35 COSM3364888 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.221T>G p.V74G 3:10142068-10142068 5
36 COSM14390 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.269A>T p.N90I 3:10142116-10142116 5
37 COSM6918107 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.302T>G p.L101R 3:10142149-10142149 5
38 COSM18350 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.256C>T p.P86S 3:10142103-10142103 5
39 COSM14368 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.473T>A p.L158Q 3:10149796-10149796 5
40 COSM17721 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.241C>T p.P81S 3:10142088-10142088 5
41 COSM17711 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.208G>T p.E70* 3:10142055-10142055 5
42 COSM97154 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.565G>T p.E189* 3:10149888-10149888 5
43 COSM17612 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.481C>T p.R161* 3:10149804-10149804 5
44 COSM17928 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.463G>C p.V155L 3:10146636-10146636 5
45 COSM97146 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.357C>A p.F119L 3:10146530-10146530 5
46 COSM17789 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.525C>A p.Y175* 3:10149848-10149848 5
47 COSM26992 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.404T>G p.L135* 3:10146577-10146577 5
48 COSM14372 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.203C>A p.S68* 3:10142050-10142050 5
49 COSM34019 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.361G>T p.D121Y 3:10146534-10146534 5
50 COSM18266 VHL kidney,NS,carcinoma,clear cell renal cell carcinoma c.461C>T p.P154L 3:10146634-10146634 5

Expression for Multilocular Clear Cell Renal Cell Carcinoma

Search GEO for disease gene expression data for Multilocular Clear Cell Renal Cell Carcinoma.

Pathways for Multilocular Clear Cell Renal Cell Carcinoma

Pathways related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 SLC2A4 TGFB2 TGFB3 TSC2
2 11.99 C1QBP SLC2A4 TSC2
3
Show member pathways
11.88 FLCN TGFB2 TGFB3
4 11.51 TGFB2 TGFB3
5 11.5 TGFB2 TGFB3
6
Show member pathways
11.47 SLC2A4 TSC2
7 11.45 TGFB2 TGFB3
8
Show member pathways
11.37 TGFB2 TGFB3
9 11.35 TGFB2 TGFB3
10 11.34 TGFB2 TGFB3 TSC2
11 11.27 TGFB2 TGFB3
12 11.21 TGFB2 TGFB3
13 11.16 TGFB2 TGFB3
14 11.09 TGFB2 TGFB3
15 11.02 TGFB2 TGFB3
16
Show member pathways
10.94 SLC2A4 TGFB2 TGFB3
17 10.63 TGFB2 TGFB3

GO Terms for Multilocular Clear Cell Renal Cell Carcinoma

Cellular components related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 TGFB2 TGFB3
2 T-tubule GO:0030315 8.62 SLC2A4 TGFB3

Biological processes related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 TGFB2 TGFB3 TSC2
2 positive regulation of apoptotic process GO:0043065 9.71 C1QBP FLCN TGFB3
3 neural tube closure GO:0001843 9.61 TGFB2 TSC2
4 hemopoiesis GO:0030097 9.6 FLCN TGFB2
5 cell development GO:0048468 9.58 TGFB2 TGFB3
6 regulation of MAPK cascade GO:0043408 9.58 TGFB2 TGFB3
7 SMAD protein signal transduction GO:0060395 9.57 TGFB2 TGFB3
8 negative regulation of protein kinase B signaling GO:0051898 9.56 FLCN TSC2
9 inner ear development GO:0048839 9.55 TGFB2 TGFB3
10 positive regulation of cell adhesion GO:0045785 9.52 C1QBP FLCN
11 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.51 TGFB2 TGFB3
12 positive regulation of cell division GO:0051781 9.49 TGFB2 TGFB3
13 positive regulation of epithelial to mesenchymal transition GO:0010718 9.48 TGFB2 TGFB3
14 positive regulation of protein secretion GO:0050714 9.46 TGFB2 TGFB3
15 negative regulation of TOR signaling GO:0032007 9.43 FLCN TSC2
16 response to progesterone GO:0032570 9.4 TGFB2 TGFB3
17 odontogenesis GO:0042476 9.37 TGFB2 TGFB3
18 cell-cell junction organization GO:0045216 9.32 TGFB2 TGFB3
19 secondary palate development GO:0062009 9.26 TGFB2 TGFB3
20 salivary gland morphogenesis GO:0007435 9.16 TGFB2 TGFB3
21 negative regulation of macrophage cytokine production GO:0010936 8.96 TGFB2 TGFB3
22 uterine wall breakdown GO:0042704 8.62 TGFB2 TGFB3

Molecular functions related to Multilocular Clear Cell Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.16 TGFB2 TGFB3
2 type II transforming growth factor beta receptor binding GO:0005114 8.96 TGFB2 TGFB3
3 type III transforming growth factor beta receptor binding GO:0034714 8.62 TGFB2 TGFB3

Sources for Multilocular Clear Cell Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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