MCID: MLT008
MIFTS: 43

Multinodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

MalaCards integrated aliases for Multinodular Goiter:

Name: Multinodular Goiter 12 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050489
UMLS 73 C0342208

Summaries for Multinodular Goiter

Disease Ontology : 12 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary : Multinodular Goiter is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and plummer's disease. An important gene associated with Multinodular Goiter is MNG3 (Multinodular Goiter-3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Autoantibodies and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related phenotypes are endocrine/exocrine gland and behavior/neurological

Wikipedia : 76 A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre is... more...

Related Diseases for Multinodular Goiter

Diseases in the Multinodular Goiter family:

Goiter, Multinodular 2 Goiter, Multinodular 3

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.3 DICER1 TG TPO
2 plummer's disease 32.9 TG TPO
3 graves' disease 32.6 GNAS TG TPO TSHR
4 hyperthyroidism 30.9 GNAS TG TPO TSHR
5 goiter 30.5 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
6 endemic goiter 30.5 TG TPO TSHR
7 thyroiditis 30.3 CALCA TG TPO TSHR
8 hyperthyroxinemia 30.2 TPO TSHR
9 suppurative thyroiditis 30.1 CALCA TG
10 anaplastic thyroid cancer 29.9 NKX2-1 PAX8 TG TPO
11 nodular goiter 29.9 CALCA TG TPO TSHR
12 neonatal hypothyroidism 29.8 PAX8 TG TPO TSHR
13 papillary carcinoma 29.8 CALCA NKX2-1 PAX8 TG TPO TSHR
14 thyroid cancer, nonmedullary, 2 29.3 CALCA HRAS NKX2-1 PAX8 TG TPO
15 congenital hypothyroidism 29.1 GNAS NKX2-1 PAX8 SLC26A4 TG TPO
16 thyroid cancer 29.1 CALCA DICER1 GNAS HRAS NKX2-1 PAX8
17 hypothyroidism 29.0 CALCA GNAS NKX2-1 PAX8 SLC26A4 TG
18 follicular adenoma 28.9 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
19 daneman davy mancer syndrome 12.2
20 goiter, multinodular, cystic renal disease, and digital anomalies 11.5
21 goiter, multinodular 2 11.4
22 goiter, multinodular 3 11.4
23 short stature, microcephaly, and endocrine dysfunction 11.4
24 thyroid cancer, nonmedullary, 4 11.3
25 myopathy - thyrotoxic 11.3
26 adenoma 10.6
27 thyroid cancer, nonmedullary, 1 10.4
28 parathyroid adenoma 10.4
29 primary hyperparathyroidism 10.4
30 hyperparathyroidism 10.4
31 hashimoto encephalopathy 10.3 TPO TSHR
32 hypothyroidism, congenital, nongoitrous, 1 10.2 GNAS TSHR
33 subacute lymphocytic thyroiditis 10.2 TG TPO
34 familial thyroid dyshormonogenesis 10.2 TG TPO
35 postsurgical hypothyroidism 10.2 TG TSHR
36 ovarian germ cell teratoma 10.2 NKX2-1 TG
37 colloid adenoma 10.2 NKX2-1 TG
38 ovarian germ cell cancer 10.2 NKX2-1 TG
39 meningitis and encephalitis 10.2 CP SOD1
40 premature menopause 10.2 TG TPO
41 graves disease 1 10.2 TG TPO TSHR
42 myxedema 10.2 TG TPO TSHR
43 toxic diffuse goiter 10.2 TG TPO TSHR
44 subacute thyroiditis 10.2 TG TPO TSHR
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TG TPO TSHR
46 autoimmune disease of endocrine system 10.2 TG TPO TSHR
47 respiratory failure 10.1
48 horner's syndrome 10.1
49 leydig cell tumor 10.1
50 sertoli-leydig cell tumor 10.1

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to Multinodular Goiter

Symptoms & Phenotypes for Multinodular Goiter

MGI Mouse Phenotypes related to Multinodular Goiter:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
2 behavior/neurological MP:0005386 10.18 CP DICER1 GNAS HRAS NKX2-1 PAX8
3 homeostasis/metabolism MP:0005376 10.18 CP DICER1 GNAS HRAS NKX2-1 PAX8
4 growth/size/body region MP:0005378 10.16 DICER1 GNAS HRAS NKX2-1 PAX8 SOD1
5 cardiovascular system MP:0005385 10.11 CP DICER1 GNAS GSR HRAS NKX2-1
6 immune system MP:0005387 10.02 CP DICER1 GNAS SLC26A4 SOD1 TG
7 craniofacial MP:0005382 9.97 DICER1 GNAS HRAS PAX8 TPO XRCC4
8 hearing/vestibular/ear MP:0005377 9.91 GNAS PAX8 SLC26A4 SOD1 TPO TSHR
9 nervous system MP:0003631 9.9 CP DICER1 GNAS HRAS NKX2-1 PAX8
10 limbs/digits/tail MP:0005371 9.8 DICER1 GNAS PAX8 TG TPO TSHR
11 neoplasm MP:0002006 9.8 DICER1 GNAS HRAS NKX2-1 SOD1 TSHR
12 skeleton MP:0005390 9.7 DICER1 GNAS HRAS NKX2-1 PAX8 SLC26A4
13 vision/eye MP:0005391 9.17 CP DICER1 GSR PAX8 SOD1 TPO

Drugs & Therapeutics for Multinodular Goiter

Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Phase 4
2 Hormones Phase 2,Phase 1
3 Hormone Antagonists Phase 1
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
5
Iodine Approved, Investigational Not Applicable 7553-56-2 807
6 cadexomer iodine Not Applicable
7 Coagulants
8 Hemostatics
9 Anesthetics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
3 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
4 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
5 Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1 Modified Release rhTSH
6 Budget Impact of Harmonic FOCUS in Thyroidectomy Unknown status NCT01658085
7 Three-Year Follow-up of Radioiodine Therapy for Goitre Completed NCT00509483 Not Applicable
8 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288 Not Applicable
9 Clinical Trial on Harmonic Focus Shears Completed NCT01003652
10 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
11 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565 Not Applicable
12 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease Completed NCT00666315
13 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
14 Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
15 Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules Completed NCT00571090
16 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
17 Alterations in Quality of Life After Thyroidectomy for Benign Thyroid Disease Recruiting NCT03566537
18 Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer Withdrawn NCT00954837 Not Applicable

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Genetic tests related to Multinodular Goiter:

# Genetic test Affiliating Genes
1 Multinodular Goiter 29

Anatomical Context for Multinodular Goiter

MalaCards organs/tissues related to Multinodular Goiter:

41
Thyroid, Bone, Lung, Pituitary, T Cells, Kidney, Ovary

Publications for Multinodular Goiter

Articles related to Multinodular Goiter:

(show top 50) (show all 330)
# Title Authors Year
1
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
2
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
3
Letter to &amp;quot;the Prevalence of Incidental Thyroid Carcinoma in Patients Who Underwent Thyroidectomy for Multinodular Goiter&amp;quot;. ( 29581698 )
2018
4
Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter. ( 29641730 )
2018
5
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations. ( 29538609 )
2018
6
An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter. ( 29897006 )
2018
7
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
8
Airway Considerations in Case of a Large Multinodular Goiter. ( 29284884 )
2017
9
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
10
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
11
Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis. ( 29442060 )
2017
12
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
13
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
14
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
15
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
16
Neglected nontoxic multinodular goiter presented as a large neck mass. ( 28265406 )
2017
17
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
18
Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. ( 28506088 )
2017
19
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
20
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
21
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
22
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
23
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
24
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
25
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
26
Prominent Cold Nodule in Multinodular Goiter Revealed to Be Thyrolipoma: A Case Report. ( 28974966 )
2016
27
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
28
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
29
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
30
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
31
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? ( 28005977 )
2016
32
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. ( 26871832 )
2016
33
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
34
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
35
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. ( 27988915 )
2016
36
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
37
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
38
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
39
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. ( 26982637 )
2016
40
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. ( 25981745 )
2015
41
The Natural History of Multinodular Goiter. ( 26364072 )
2015
42
Large multinodular goiter--outpatient radioiodine treatment. ( 26323466 )
2015
43
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? ( 25594634 )
2015
44
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. ( 27011525 )
2015
45
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. ( 26319784 )
2015
46
Thyroid storm associated with multinodular goiter: a difficult problem to treat. ( 25772969 )
2015
47
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? ( 26702247 )
2015
48
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. ( 24555692 )
2014
49
Adenomatous multinodular goiter causing airway obstruction in an infant. ( 24622964 )
2014
50
Congenital thyroid hemiagenesis with multinodular goiter. ( 25379177 )
2014

Variations for Multinodular Goiter

Expression for Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for Multinodular Goiter

GO Terms for Multinodular Goiter

Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 CALCA GNAS TSHR
2 activation of adenylate cyclase activity GO:0007190 9.33 CALCA GNAS TSHR
3 hormone biosynthetic process GO:0042446 9.32 TG TPO
4 iodide transport GO:0015705 9.26 SLC26A4 TG
5 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
6 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Multinodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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