MCID: MLT008
MIFTS: 43

Multinodular Goiter

Categories: Endocrine diseases

Aliases & Classifications for Multinodular Goiter

MalaCards integrated aliases for Multinodular Goiter:

Name: Multinodular Goiter 12 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050489
UMLS 73 C0342208

Summaries for Multinodular Goiter

Disease Ontology : 12 A goiter characterized by a multinodular enlargement of the thyroid gland.

MalaCards based summary : Multinodular Goiter is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and graves' disease. An important gene associated with Multinodular Goiter is MNG2 (Multinodular Goiter 2), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Longevity regulating pathway. The drugs Autoantibodies and Salmon Calcitonin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and trachea, and related phenotypes are endocrine/exocrine gland and behavior/neurological

Wikipedia : 76 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Related Diseases for Multinodular Goiter

Diseases in the Multinodular Goiter family:

Goiter, Multinodular 2 Goiter, Multinodular 3

Diseases related to Multinodular Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.5 DICER1 TG TPO
2 graves' disease 32.8 TG TPO TSHR
3 plummer's disease 31.1 TG TPO
4 thyroiditis 31.0 CALCA TG TPO TSHR
5 hyperthyroidism 30.9 GNAS TG TPO TSHR
6 hyperthyroxinemia 30.6 TPO TSHR
7 suppurative thyroiditis 30.2 CALCA TG
8 thyroid cancer, nonmedullary, 1 29.8 NKX2-1 PAX8 TG
9 endemic goiter 29.7 CALCA TG TPO TSHR
10 nodular goiter 29.5 CALCA TG TPO TSHR
11 neonatal hypothyroidism 29.1 PAX8 TG TPO TSHR
12 anaplastic thyroid cancer 29.1 NKX2-1 PAX8 TG TPO
13 congenital hypothyroidism 28.5 NKX2-1 PAX8 TG TPO TSHR
14 papillary carcinoma 27.9 CALCA NKX2-1 PAX8 TG TPO TSHR
15 goiter 27.3 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
16 differentiated thyroid carcinoma 27.0 DICER1 HRAS NKX2-1 PAX8 TG TPO
17 thyroid cancer, nonmedullary, 2 26.8 CALCA HRAS NKX2-1 PAX8 TG TPO
18 follicular adenoma 26.5 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
19 hypothyroidism 26.3 CALCA GNAS NKX2-1 PAX8 SLC26A4 TG
20 thyroid cancer 25.8 CALCA GNAS HRAS NKX2-1 PAX8 SLC26A4
21 daneman davy mancer syndrome 12.0
22 goiter, multinodular, cystic renal disease, and digital anomalies 11.3
23 goiter, multinodular 2 11.3
24 goiter, multinodular 3 11.3
25 short stature, microcephaly, and endocrine dysfunction 11.3
26 thyroid cancer, nonmedullary, 4 11.1
27 myopathy - thyrotoxic 11.1
28 hypothyroidism, congenital, nongoitrous, 1 10.8 GNAS TSHR
29 familial thyroid dyshormonogenesis 10.7 TG TPO
30 subacute lymphocytic thyroiditis 10.7 TG TPO
31 congenital rubella 10.6 CAT TPO
32 ovarian germ cell teratoma 10.6 NKX2-1 TG
33 premature menopause 10.6 TG TPO
34 embryoma 10.6 DICER1 NKX2-1
35 ovarian germ cell cancer 10.6 NKX2-1 TG
36 hypothyroidism, congenital, nongoitrous, 4 10.5 TG TPO
37 malignant teratoma 10.5 NKX2-1 TG
38 graves disease 1 10.5 TG TPO TSHR
39 myxedema 10.5 TG TPO TSHR
40 toxic diffuse goiter 10.5 TG TPO TSHR
41 subacute thyroiditis 10.5 TG TPO TSHR
42 autoimmune disease of endocrine system 10.5 TG TPO TSHR
43 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5 TG TPO TSHR
44 hypersensitivity reaction disease 10.5 TG TPO TSHR
45 adenoma 10.4
46 struma ovarii 10.4 NKX2-1 TG TSHR
47 dyshormonogenic goiter 10.4 SLC26A4 TG
48 athetosis 10.4 CP NKX2-1
49 pulmonary blastoma 10.4 DICER1 NKX2-1
50 pernicious anemia 10.4 TG TPO

Graphical network of the top 20 diseases related to Multinodular Goiter:



Diseases related to Multinodular Goiter

Symptoms & Phenotypes for Multinodular Goiter

MGI Mouse Phenotypes related to Multinodular Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 GNAS SLC26A4 HRAS NKX2-1 DICER1 PAX8
2 behavior/neurological MP:0005386 10.13 PAX8 GNAS HRAS CP NKX2-1 DICER1
3 cellular MP:0005384 10.11 DICER1 PAX8 GNAS CAT CP NKX2-1
4 growth/size/body region MP:0005378 10.07 PAX8 GNAS HRAS NKX2-1 DICER1 TPO
5 homeostasis/metabolism MP:0005376 10.07 PAX8 GNAS SLC26A4 HRAS CAT CP
6 craniofacial MP:0005382 9.91 PAX8 GNAS HRAS DICER1 TPO XRCC4
7 hearing/vestibular/ear MP:0005377 9.8 PAX8 GNAS SLC26A4 TPO TSHR SOD1
8 neoplasm MP:0002006 9.76 GNAS HRAS CAT NKX2-1 DICER1 TSHR
9 nervous system MP:0003631 9.7 PAX8 GNAS SLC26A4 HRAS CP NKX2-1
10 skeleton MP:0005390 9.32 PAX8 GNAS SLC26A4 HRAS NKX2-1 DICER1

Drugs & Therapeutics for Multinodular Goiter

Drugs for Multinodular Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies Phase 4
2
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
3
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
4 Hormones Phase 2,Phase 1
5 Bone Density Conservation Agents Phase 2
6 calcitonin Phase 2,Not Applicable
7 Hormone Antagonists Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
9
Iodine Approved, Investigational Not Applicable 7553-56-2 807
10 cadexomer iodine Not Applicable
11 Coagulants
12 Hemostatics
13 Anesthetics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
3 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
4 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
5 Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1 Modified Release rhTSH
6 Budget Impact of Harmonic FOCUS in Thyroidectomy Unknown status NCT01658085
7 Three-Year Follow-up of Radioiodine Therapy for Goitre Completed NCT00509483 Not Applicable
8 Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter Completed NCT01588288 Not Applicable
9 Clinical Trial on Harmonic Focus Shears Completed NCT01003652
10 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
11 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565 Not Applicable
12 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease Completed NCT00666315
13 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
14 Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
15 Prediction of Thyroid Cancer From Ultrasonographic Characteristics of Thyroid Nodules Completed NCT00571090
16 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
17 Alterations in Quality of Life After Thyroidectomy for Benign Thyroid Disease Recruiting NCT03566537
18 Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer Withdrawn NCT00954837 Not Applicable

Search NIH Clinical Center for Multinodular Goiter

Genetic Tests for Multinodular Goiter

Genetic tests related to Multinodular Goiter:

# Genetic test Affiliating Genes
1 Multinodular Goiter 29

Anatomical Context for Multinodular Goiter

MalaCards organs/tissues related to Multinodular Goiter:

41
Thyroid, Bone, Trachea, Pituitary, Lung, Colon, Heart

Publications for Multinodular Goiter

Articles related to Multinodular Goiter:

(show top 50) (show all 330)
# Title Authors Year
1
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
2
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
3
Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter. ( 29641730 )
2018
4
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations. ( 29538609 )
2018
5
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
6
Airway Considerations in Case of a Large Multinodular Goiter. ( 29284884 )
2017
7
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
8
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
9
Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis. ( 29442060 )
2017
10
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
11
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
12
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
13
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
14
Neglected nontoxic multinodular goiter presented as a large neck mass. ( 28265406 )
2017
15
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
16
Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. ( 28506088 )
2017
17
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
18
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
19
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
20
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
21
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
22
Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter. ( 26841373 )
2016
23
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
24
Prominent Cold Nodule in Multinodular Goiter Revealed to Be Thyrolipoma: A Case Report. ( 28974966 )
2016
25
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
26
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
27
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
28
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
29
Should the Prevalence of Incidental Thyroid Cancer Determine the Extent of Surgery in Multinodular Goiter? ( 28005977 )
2016
30
Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure: A Case Report. ( 26871832 )
2016
31
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
32
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
33
Airway Obstruction Caused by Substernal Thyrotoxic Multinodular Goiter. ( 27988915 )
2016
34
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
35
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
36
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
37
Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis. ( 26982637 )
2016
38
Dysregulation of clathrin promotes thyroid cell growth and contributes to multinodular goiter pathogenesis. ( 25981745 )
2015
39
The Natural History of Multinodular Goiter. ( 26364072 )
2015
40
Large multinodular goiter--outpatient radioiodine treatment. ( 26323466 )
2015
41
Should subtotal thyroidectomy be abandoned in multinodular goiter patients from endemic regions requiring surgery? ( 25594634 )
2015
42
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. ( 27011525 )
2015
43
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter. ( 26319784 )
2015
44
Thyroid storm associated with multinodular goiter: a difficult problem to treat. ( 25772969 )
2015
45
Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out? ( 26702247 )
2015
46
Parasitic thyroid nodules in patient with nontoxic multinodular goiter: a case report. ( 24555692 )
2014
47
Adenomatous multinodular goiter causing airway obstruction in an infant. ( 24622964 )
2014
48
Congenital thyroid hemiagenesis with multinodular goiter. ( 25379177 )
2014
49
Multinodular goiter with retrosternal extension causing airway obstruction: Management in intensive care unit and operating room. ( 25136197 )
2014
50
Anaplastic carcinoma and toxic multinodular goiter: an unusual presentation. ( 25759806 )
2014

Variations for Multinodular Goiter

Expression for Multinodular Goiter

Search GEO for disease gene expression data for Multinodular Goiter.

Pathways for Multinodular Goiter

GO Terms for Multinodular Goiter

Biological processes related to Multinodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.63 CAT SOD1 TPO
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.5 CALCA GNAS TSHR
3 hydrogen peroxide catabolic process GO:0042744 9.48 CAT TPO
4 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.43 GNAS TSHR
5 response to reactive oxygen species GO:0000302 9.4 CAT SOD1
6 hormone biosynthetic process GO:0042446 9.37 TG TPO
7 activation of adenylate cyclase activity GO:0007190 9.33 CALCA GNAS TSHR
8 iodide transport GO:0015705 9.26 SLC26A4 TG
9 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
10 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Multinodular Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 9.16 CAT SOD1
2 peroxidase activity GO:0004601 8.96 CAT TPO
3 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Multinodular Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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