MCID: MLT001
MIFTS: 38

Multiple Chemical Sensitivity

Categories: Immune diseases

Aliases & Classifications for Multiple Chemical Sensitivity

MalaCards integrated aliases for Multiple Chemical Sensitivity:

Name: Multiple Chemical Sensitivity 12 73 44 15 17 70
Environmental Illness 12 70
Idiopathic Environmental Illness 12
Total Allergy Syndrome 12
20th Century Disease 12
Chemical Aids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4661
MeSH 44 D018777
SNOMED-CT 67 702772003
UMLS 70 C0242992 C0282504

Summaries for Multiple Chemical Sensitivity

Disease Ontology : 12 A syndrome that is an adverse physical reaction to low levels of many common chemicals.

MalaCards based summary : Multiple Chemical Sensitivity, also known as environmental illness, is related to persian gulf syndrome and major depressive disorder. An important gene associated with Multiple Chemical Sensitivity is PON1 (Paraoxonase 1), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. Affiliated tissues include skin, brain and pituitary.

Wikipedia : 73 Multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI), is an... more...

Related Diseases for Multiple Chemical Sensitivity

Diseases related to Multiple Chemical Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 persian gulf syndrome 30.3 VIP PON2 PON1
2 major depressive disorder 29.7 MTHFR CYP2D6 CYP2C9 CYP2C19
3 disease of mental health 27.8 VIP SOD2 PON1 MTHFR GSTM1 CYP2D6
4 chronic fatigue syndrome 10.6
5 fibromyalgia 10.5
6 somatization disorder 10.4
7 sick building syndrome 10.4
8 outlet dysfunction constipation 10.2 CYP2D6 CYP2C19
9 sulfonamide allergy 10.2 CYP2D6 CYP2C9
10 mutagen sensitivity 10.2 NAT2 GSTM1
11 esophageal candidiasis 10.2 CYP2C9 CYP2C19
12 allergic disease 10.2
13 substance abuse 10.2
14 chronic pain 10.2
15 thiopurines, poor metabolism of, 1 10.1 CYP3A5 CYP2D6
16 toxic oil syndrome 10.1 NAT2 GSTM1 CYP2D6
17 mental depression 10.1
18 rhinitis 10.1
19 panic disorder 10.1
20 cytokine deficiency 10.1
21 hepatitis d 10.1 CYP2D6 CYP2C9
22 hypertrophy of tongue papillae 10.1 CYP2D6 CYP2C9 CYP2C19
23 phenytoin toxicity 10.1 NAT2 CYP2C9 CYP2C19
24 trimethoprim allergy 10.1 NAT2 GSTM1 CYP2C9
25 severe cutaneous adverse reaction 10.1 CYP2D6 CYP2C9 CYP2C19
26 acetaminophen metabolism 10.1 GSTP1 CYP2D6 CYP2C19
27 coronary heart disease 1 10.1 PON2 PON1
28 oligoasthenoteratozoospermia 10.0 GSTP1 GSTM1
29 beta-thalassemia major 10.0 MTHFR GSTM1
30 autoimmune disease 10.0
31 dermatitis, atopic 10.0
32 urticaria 10.0
33 post-traumatic stress disorder 10.0
34 psychotic disorder 10.0
35 mood disorder 10.0
36 phobic disorder 10.0
37 severe combined immunodeficiency 10.0
38 depression 10.0
39 intracranial vasospasm 10.0 VIP MTHFR
40 tardive dyskinesia 10.0 SOD2 CYP2D6
41 mixed phenotype acute leukemia 10.0 MTHFR GSTM1
42 age-related hearing loss 10.0 SOD2 NAT2
43 atherosclerosis susceptibility 9.9 PON2 PON1 MTHFR
44 larynx cancer 9.9 NAT2 GSTP1 GSTM1
45 gastroesophageal adenocarcinoma 9.9 MTHFR GSTP1 GSTM1
46 beta-thalassemia 9.9 PON1 MTHFR GSTM1
47 cardia cancer 9.9 MTHFR GSTP1 GSTM1
48 exfoliation syndrome 9.9 MTHFR GSTP1 GSTM1
49 behcet syndrome 9.9 PON1 NAT2 MTHFR
50 gastroesophageal reflux 9.9

Graphical network of the top 20 diseases related to Multiple Chemical Sensitivity:



Diseases related to Multiple Chemical Sensitivity

Symptoms & Phenotypes for Multiple Chemical Sensitivity

Drugs & Therapeutics for Multiple Chemical Sensitivity

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness. Completed NCT01536288 Phase 2 Rhodiola crenulata;placebo
2 Medical Provider Experience and Assessment on Healthcare Decisions Regarding Dietary and Environmental Allergen Exposure Unknown status NCT03144908
3 Mindfulness-based Cognitive Therapy for Individuals With Multiple Chemical Sensitivity Completed NCT01240395
4 Transcranial Pulsed Electromagnetic Fields for Multiple Chemical Sensitivity: a Study Protocol for a Randomized, Double-blind, Placebo-controlled Trial Completed NCT01834781
5 A Pilot Trial on the Effect of Mindfulness-based Cognitive Therapy Versus "Treatment as Usual" for Individuals With Multiple Chemical Sensitivities Completed NCT00669448
6 Evaluation of a Specialized Therapeutic Care of Patients Presenting an Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields Completed NCT01854801
7 Identify Unique Set of Proteins in Cerebrospinal Fluid, Which Are Believed to be Found in Chronic Fatigue Syndrome Participants, But Not in Healthy Controls. Completed NCT00810329
8 Psychosocial Interventions for Indoor Air -Related Functional Symptoms - Randomized Controlled Trial (RCT) Completed NCT02069002

Search NIH Clinical Center for Multiple Chemical Sensitivity

Cochrane evidence based reviews: multiple chemical sensitivity

Genetic Tests for Multiple Chemical Sensitivity

Anatomical Context for Multiple Chemical Sensitivity

MalaCards organs/tissues related to Multiple Chemical Sensitivity:

40
Skin, Brain, Pituitary, Eye, Spinal Cord, Heart, Adrenal Gland

Publications for Multiple Chemical Sensitivity

Articles related to Multiple Chemical Sensitivity:

(show top 50) (show all 619)
# Title Authors PMID Year
1
Irritant-induced Asthma Caused by Aerotoxic Syndrome. 61
33719009 2021
2
PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity. 61
33728967 2021
3
Seasonal Trends for Environmental Illness Incidence in the U.S. Army. 61
33605408 2021
4
Multiple chemical sensitivity described in the Danish general population: Cohort characteristics and the importance of screening for functional somatic syndrome comorbidity-The DanFunD study. 61
33626058 2021
5
Fibromyalgia, Chronic Fatigue Syndrome, and Multiple Chemical Sensitivity: Illness Experiences. 61
30917692 2021
6
Food Implications in Central Sensitization Syndromes. 61
33352747 2020
7
The role of sensory and olfactory pathways in multiple chemical sensitivity. 61
33070122 2020
8
Chemical Exposure, Risk of Multiple Chemical Sensitivity, and Occupational Safety. 61
32995065 2020
9
[What scientific evidence do the current classifications have in order to assess occupational disability in patients with central sensitisation syndrome?] 61
32828657 2020
10
Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms. 61
32916833 2020
11
Two Cases of Multiple Chemical Sensitivity Successfully Treated With Kampo Medicine. 61
32827411 2020
12
Hypnosis as Sole Anesthesia for Dental Removal in a Patient with Multiple Chemical Sensitivity. 61
32543265 2020
13
Study of the Correlation Between Multiple Chemical Sensitivity and Personality Using the Quick Environmental Exposure Sensitivity Inventory Questionnaire and the Temperament and Character Inventory. 61
32730039 2020
14
Prevalence of functional somatic syndromes and bodily distress syndrome in the Danish population: the DanFunD study. 61
31409218 2020
15
Electromagnetic hypersensitivity (EHS, microwave syndrome) - Review of mechanisms. 61
32289567 2020
16
High prevalence of neurological sequelae and multiple chemical sensitivity among occupants of a Finnish police station damaged by dampness microbiota. 61
32544007 2020
17
Technical Assessment of Ultrasonic Cerebral Tomosphygmography and New Scientific Evaluation of Its Clinical Interest for the Diagnosis of Electrohypersensitivity and Multiple Chemical Sensitivity. 61
32599757 2020
18
Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort. 61
32596012 2020
19
The impact of multiple chemical sensitivity on people's social and occupational functioning; a systematic review of qualitative research studies. 61
32114179 2020
20
Dietary factors and endocrine consequences of multiple chemical sensitivity. 61
31874795 2020
21
Mechanisms underlying nontoxic indoor air health problems: A review. 61
32163882 2020
22
The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity. 61
32182774 2020
23
A Proposal for Clinical Biomarkers in Multiple Chemical Sensitivity. 61
32141487 2020
24
Electrohypersensitivity as a Newly Identified and Characterized Neurologic Pathological Disorder: How to Diagnose, Treat, and Prevent It. 61
32168876 2020
25
Multiple chemical sensitivity (MCS) - a guide for dermatologists on how to manage affected individuals. 61
32026633 2020
26
Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population: DanFunD. 61
32094442 2020
27
Computerized screening of G-protein coupled receptors to identify and characterize olfactory receptors. 61
32019429 2020
28
OnabotulinumtoxinA Is an Effective Treatment for Chronic Migraine in Patients With Comorbid Fibromyalgia. 61
33178117 2020
29
Functional symptoms in dermatology: Part 2. 61
31468592 2020
30
Stepwise surgery with variable adjustments for severe blepharochalasis with multiple chemical sensitivity: a case report. 61
32128348 2020
31
Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model. 61
31881664 2019
32
The effect of comorbid medical and psychiatric diagnoses on chronic fatigue syndrome. 61
31642345 2019
33
Multiple chemical sensitivity: pursuit of a scientific consensus, need for a public health response. Commentary. 61
31850857 2019
34
Speculative Fiction and the Political Economy of Healthcare: Chang-Rae Lee's On Such a Full Sea. 61
29860646 2019
35
How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain. 61
31407924 2019
36
Contact allergy to metals and "multiple chemical sensitivity". 61
31012485 2019
37
Contact allergy to metals and multiple chemical sensitivity. 61
30843222 2019
38
Prevalence and risk factors for multiple chemical sensitivity in Australia. 61
31193443 2019
39
Barriers of physical activity of women post breast cancer treatment in rural Poland. 61
31033414 2019
40
Polyallergy (Multiple Chemical Sensitivity) is Associated with Excessive Healthcare Utilization, Greater Psychotropic Use, and Greater Mental Health/Functional Somatic Syndrome Disorder Diagnoses: A Large Cohort Retrospective Study. 61
30122642 2019
41
Multiple chemical sensitivity syndrome is not caused by contact allergy. 61
30537140 2019
42
Exploratory Investigation of a Brief Cognitive Behavioral Intervention and Transcranial Direct Current Stimulation on Odor Sensitivity. 61
30762663 2019
43
Becoming electro-hypersensitive: A replication study. 61
30920673 2019
44
General anesthetic management of a patient with multiple chemical sensitivity for oral surgery: a case report. 61
32025995 2019
45
Gulf War Illness: Unifying Hypothesis for a Continuing Health Problem. 61
30609834 2019
46
New criteria for multiple chemical sensitivity based on the Quick Environmental Exposure and Sensitivity Inventory developed in response to rapid changes in ongoing chemical exposures among Japanese. 61
31026284 2019
47
Multiple Chemical Sensitivity in Chemical Laboratory Workers. 61
30559998 2018
48
Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study. 61
30547814 2018
49
Characteristics and determinants of dietary intake and physical activity in a group of patients with multiple chemical sensitivity. 61
30309810 2018
50
The enduring legacy of black lung: environmental health and contested illness in Appalachia. 61
29956342 2018

Variations for Multiple Chemical Sensitivity

Expression for Multiple Chemical Sensitivity

Search GEO for disease gene expression data for Multiple Chemical Sensitivity.

Pathways for Multiple Chemical Sensitivity

Pathways related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 PON2 PON1 NAT2 MTHFR GSTP1 GSTM1
2
Show member pathways
12.96 NAT2 GSTP1 GSTM1 CYP3A5 CYP2D6 CYP2C9
3
Show member pathways
12.43 NAT2 GSTP1 GSTM1 CYP3A5 CYP2D6 CYP2C9
4
Show member pathways
12.02 PON2 PON1 CYP2C9 CYP2C19
5 11.84 CYP2D6 CYP2C9 CYP2C19
6
Show member pathways
11.78 CYP3A5 CYP2D6 CYP2C9 CYP2C19
7
Show member pathways
11.67 GSTP1 GSTM1 CYP2D6
8
Show member pathways
11.48 CYP3A5 CYP2D6 CYP2C9 CYP2C19
9
Show member pathways
11.47 CYP3A5 CYP2C9 CYP2C19
10
Show member pathways
11.44 CYP3A5 CYP2D6 CYP2C9
11 11.42 CYP3A5 CYP2C9 CYP2C19
12
Show member pathways
11.42 PON1 CYP2D6 CYP2C9 CYP2C19
13
Show member pathways
11.34 NAT2 GSTP1 GSTM1
14
Show member pathways
11.21 CYP3A5 CYP2D6 CYP2C9
15 11.2 CYP2D6 CYP2C19
16 11.16 CYP3A5 CYP2C9 CYP2C19
17
Show member pathways
11.16 GSTP1 GSTM1 CYP3A5 CYP2D6 CYP2C9 CYP2C19
18
Show member pathways
11.15 CYP3A5 CYP2D6 CYP2C9 CYP2C19
19 11.09 GSTP1 GSTM1
20 11.01 GSTP1 GSTM1 CYP2C9
21 10.79 GSTP1 CYP3A5
22 10.79 CYP2D6 CYP2C19
23
Show member pathways
10.79 CYP3A5 CYP2D6 CYP2C9 CYP2C19
24
Show member pathways
10.64 CYP2D6 CYP2C9
25 10.49 PON2 PON1
26 10.42 GSTP1 CYP2C9

GO Terms for Multiple Chemical Sensitivity

Cellular components related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.43 PON2 PON1 CYP3A5 CYP2D6 CYP2C9 CYP2C19
2 organelle membrane GO:0031090 8.92 CYP3A5 CYP2D6 CYP2C9 CYP2C19

Biological processes related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.95 PON1 CYP3A5 CYP2D6 CYP2C9 CYP2C19
2 oxidation-reduction process GO:0055114 9.95 SOD2 MTHFR CYP3A5 CYP2D6 CYP2C9 CYP2C19
3 cholesterol metabolic process GO:0008203 9.77 PON1 CYP2D6 CYP2C9
4 response to toxic substance GO:0009636 9.76 PON2 PON1 GSTP1
5 steroid metabolic process GO:0008202 9.76 CYP3A5 CYP2D6 CYP2C9 CYP2C19
6 response to nutrient levels GO:0031667 9.73 SOD2 PON1 GSTP1
7 arachidonic acid metabolic process GO:0019369 9.63 CYP2D6 CYP2C9
8 response to amino acid GO:0043200 9.63 MTHFR GSTP1
9 prostaglandin metabolic process GO:0006693 9.62 GSTP1 GSTM1
10 long-chain fatty acid biosynthetic process GO:0042759 9.62 CYP2D6 CYP2C9
11 glutathione derivative biosynthetic process GO:1901687 9.61 GSTP1 GSTM1
12 epoxygenase P450 pathway GO:0019373 9.61 CYP2C9 CYP2C19
13 estrogen metabolic process GO:0008210 9.61 CYP3A5 CYP2D6 CYP2C9
14 lipoxygenase pathway GO:0019372 9.6 PON2 PON1
15 omega-hydroxylase P450 pathway GO:0097267 9.58 CYP2C9 CYP2C19
16 drug metabolic process GO:0017144 9.58 CYP2D6 CYP2C9 CYP2C19
17 hepoxilin biosynthetic process GO:0051122 9.57 GSTP1 GSTM1
18 heterocycle metabolic process GO:0046483 9.54 CYP2D6 CYP2C19
19 exogenous drug catabolic process GO:0042738 9.54 CYP2D6 CYP2C9 CYP2C19
20 response to L-ascorbic acid GO:0033591 9.52 SOD2 GSTP1
21 aromatic compound catabolic process GO:0019439 9.51 PON2 PON1
22 organic acid metabolic process GO:0006082 9.5 CYP2D6 CYP2C9 CYP2C19
23 alkaloid catabolic process GO:0009822 9.49 CYP3A5 CYP2D6
24 oxidative demethylation GO:0070989 9.43 CYP3A5 CYP2D6 CYP2C9
25 drug catabolic process GO:0042737 9.33 CYP3A5 CYP2D6 CYP2C9
26 monoterpenoid metabolic process GO:0016098 9.13 CYP2D6 CYP2C9 CYP2C19
27 xenobiotic metabolic process GO:0006805 9.1 NAT2 GSTP1 CYP3A5 CYP2D6 CYP2C9 CYP2C19

Molecular functions related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.8 CYP3A5 CYP2D6 CYP2C9 CYP2C19
2 oxidoreductase activity GO:0016491 9.8 SOD2 MTHFR CYP3A5 CYP2D6 CYP2C9 CYP2C19
3 iron ion binding GO:0005506 9.78 CYP3A5 CYP2D6 CYP2C9 CYP2C19
4 oxygen binding GO:0019825 9.69 SOD2 CYP3A5 CYP2C19
5 glutathione transferase activity GO:0004364 9.57 GSTP1 GSTM1
6 arachidonic acid epoxygenase activity GO:0008392 9.56 CYP2C9 CYP2C19
7 monooxygenase activity GO:0004497 9.56 CYP3A5 CYP2D6 CYP2C9 CYP2C19
8 glutathione binding GO:0043295 9.55 GSTP1 GSTM1
9 arylesterase activity GO:0004064 9.54 PON2 PON1
10 aromatase activity GO:0070330 9.54 CYP3A5 CYP2C9 CYP2C19
11 acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 9.52 PON2 PON1
12 (R)-limonene 6-monooxygenase activity GO:0052741 9.46 CYP2C9 CYP2C19
13 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.46 CYP3A5 CYP2D6 CYP2C9 CYP2C19
14 (S)-limonene 7-monooxygenase activity GO:0018676 9.43 CYP2C9 CYP2C19
15 (S)-limonene 6-monooxygenase activity GO:0018675 9.4 CYP2C9 CYP2C19
16 steroid hydroxylase activity GO:0008395 9.26 CYP3A5 CYP2D6 CYP2C9 CYP2C19
17 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.92 CYP3A5 CYP2D6 CYP2C9 CYP2C19

Sources for Multiple Chemical Sensitivity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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