MCID: MLT001
MIFTS: 40

Multiple Chemical Sensitivity

Categories: Immune diseases

Aliases & Classifications for Multiple Chemical Sensitivity

MalaCards integrated aliases for Multiple Chemical Sensitivity:

Name: Multiple Chemical Sensitivity 12 76 44 15 73
Environmental Illness 12 73
Idiopathic Environmental Illness 12
Total Allergy Syndrome 12
20th Century Disease 12
Chemical Aids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4661
MeSH 44 D018777

Summaries for Multiple Chemical Sensitivity

Disease Ontology : 12 A syndrome that is an adverse physical reaction to low levels of many common chemicals.

MalaCards based summary : Multiple Chemical Sensitivity, also known as environmental illness, is related to anxiety and chronic fatigue syndrome. An important gene associated with Multiple Chemical Sensitivity is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drug Antioxidants has been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart.

Wikipedia : 76 Multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI), is a... more...

Related Diseases for Multiple Chemical Sensitivity

Graphical network of the top 20 diseases related to Multiple Chemical Sensitivity:



Diseases related to Multiple Chemical Sensitivity

Symptoms & Phenotypes for Multiple Chemical Sensitivity

Drugs & Therapeutics for Multiple Chemical Sensitivity

Drugs for Multiple Chemical Sensitivity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antioxidants Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) Completed NCT00810368 Phase 2 Carnosine;Placebo
2 Pulsed Electromagnetic Fields for Multiple Chemical Sensitivity Completed NCT01834781 Not Applicable
3 A Pilot Trial on Effect of Mindfulness-based Cognitive Therapy for Individuals With Multiple Chemical Sensitivities (MCS) Completed NCT00669448 Not Applicable
4 Mindfulness-based Cognitive Therapy for Individuals With Multiple Chemical Sensitivity Completed NCT01240395 Not Applicable
5 Evaluation of a Specialized Therapeutic Care of Patients Presenting an Intolerance Attributed to Electromagnetic Fields Completed NCT01854801 Not Applicable
6 Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome Completed NCT00810329
7 Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans Completed NCT00810225
8 Neuromedulatory Effect of Transcranial Direct Current Electrical Stimulation in Carpal Tunnel Syndrome Recruiting NCT03795961 Not Applicable

Search NIH Clinical Center for Multiple Chemical Sensitivity

Cochrane evidence based reviews: multiple chemical sensitivity

Genetic Tests for Multiple Chemical Sensitivity

Anatomical Context for Multiple Chemical Sensitivity

MalaCards organs/tissues related to Multiple Chemical Sensitivity:

41
Testes, Brain, Heart, Skin, Amygdala

Publications for Multiple Chemical Sensitivity

Articles related to Multiple Chemical Sensitivity:

(show top 50) (show all 297)
# Title Authors Year
1
Response to Comments to the review "Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis and Future Perspectives". ( 29851737 )
2018
2
Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives. ( 29111991 )
2018
3
"Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis and Future Perspectives". ( 29851734 )
2018
4
Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity. ( 29898928 )
2018
5
Survey on changes in subjective symptoms, onset/trigger factors, allergic diseases, and chemical exposures in the past decade of Japanese patients with multiple chemical sensitivity. ( 30115513 )
2018
6
Polyallergy (Multiple Chemical Sensitivity) is Associated with Excessive Healthcare Utilization, Greater Psychotropic Use, and Greater Mental Health/Functional Somatic Syndrome Disorder Diagnoses: A Large Cohort Retrospective Study. ( 30122642 )
2018
7
Characteristics and determinants of dietary intake and physical activity in a group of patients with multiple chemical sensitivity. ( 30309810 )
2018
8
Multiple chemical sensitivity syndrome is not caused by contact allergy. ( 30537140 )
2018
9
Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study. ( 30547814 )
2018
10
Factors Contributing to the Self-Reported Prevalence of Multiple Chemical Sensitivity in Public Facility Workers and the General Population of Korea. ( 29249738 )
2017
11
Levetiracetam improves symptoms of multiple chemical sensitivity: Case report. ( 28955000 )
2017
12
Two of three patients with multiple chemical sensitivity had less symptoms and secondary hyperalgesia after transcranially applied pulsed electromagnetic fields. ( 29913674 )
2017
13
The association between multiple chemical sensitivity and mental illness: Evidence from a nationally representative sample of Canadians. ( 28712429 )
2017
14
Multiple chemical sensitivity and persistent pain states are related, may be treated with similar procedures? ( 29913672 )
2017
15
Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity. ( 27838888 )
2017
16
Multiple chemical sensitivity: Genotypic characterization, nutritional status and quality of life in 52 patients. ( 28283271 )
2017
17
Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session. ( 28232466 )
2017
18
Sevoflurane anaesthesia for nasal surgery in a patient with multiple chemical sensitivity. ( 28545941 )
2017
19
Stable Remission of Multiple Chemical Sensitivity Syndrome and Major Depression With Citalopram and 1-Month Deep Transcranial Magnetic Stimulation: A Case Report. ( 28570499 )
2017
20
(In)Visibility Online: The Benefits of Online Patient Forums for People with a Hidden Illness: The Case of Multiple Chemical Sensitivity (MCS). ( 28726292 )
2017
21
Lack of contralateral suppression in transient-evoked otoacoustic emissions in multiple chemical sensitivity: a clinical correlation study. ( 27157687 )
2016
22
Vestibular impairment in Multiple Chemical Sensitivity: Component analysis findings. ( 28262643 )
2016
23
Application of Metabolomics to Multiple Chemical Sensitivity Research. ( 26832623 )
2016
24
A randomised, placebo-controlled trial of transcranial pulsed electromagnetic fields in patients with multiple chemical sensitivity. ( 27919300 )
2016
25
Experiences of persons with multiple chemical sensitivity with mental health providers. ( 27103817 )
2016
26
Corrigendum to: Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder. ( 27783561 )
2016
27
Association of Odor Thresholds and Responses in Cerebral Blood Flow of the Prefrontal Area during Olfactory Stimulation in Patients with Multiple Chemical Sensitivity. ( 27936122 )
2016
28
In-situ Real-Time Monitoring of Volatile Organic Compound Exposure and Heart Rate Variability for Patients with Multiple Chemical Sensitivity. ( 26445055 )
2015
29
Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity. ( 26599866 )
2015
30
Assessment of cerebral blood flow in patients with multiple chemical sensitivity using near-infrared spectroscopy-recovery after olfactory stimulation: a case-control study. ( 25682122 )
2015
31
The implications of non-linear biological oscillations on human electrophysiology for electrohypersensitivity (EHS) and multiple chemical sensitivity (MCS). ( 26368042 )
2015
32
Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder. ( 26613326 )
2015
33
Involvement of Subcortical Brain Structures During Olfactory Stimulation in Multiple Chemical Sensitivity. ( 26438099 )
2015
34
Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity. ( 25917753 )
2015
35
Mindfulness-based cognitive therapy (MBCT) for multiple chemical sensitivity (MCS): Results from a randomized controlled trial with 1year follow-up. ( 26311155 )
2015
36
Clinical problems in patient with Ehlers-Danlos syndrome and Multiple Chemical Sensitivity undergoing total thyroidectomy. ( 26712072 )
2015
37
The correlation between mental health and multiple chemical sensitivity: a survey study in Japanese workers. ( 25500796 )
2015
38
Cortical activity during olfactory stimulation in multiple chemical sensitivity: a (18)F-FDG PET/CT study. ( 25690545 )
2015
39
Multiple chemical sensitivity worsens quality of life and cognitive and sensorial features of sense of smell. ( 24687801 )
2014
40
Allergic diseases and multiple chemical sensitivity in korean adults. ( 25228997 )
2014
41
An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. ( 24485486 )
2014
42
Prevalence and interannual changes in multiple chemical sensitivity in Japanese workers. ( 24477857 )
2014
43
Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells -- an fMRI study. ( 25294782 )
2014
44
Transcranial pulsed electromagnetic fields for multiple chemical sensitivity: study protocol for a randomized, double-blind, placebo-controlled trial. ( 23947742 )
2013
45
Multiple chemical sensitivity: on the scent of central sensitization. ( 22487274 )
2013
46
Allergological and toxicological aspects in a multiple chemical sensitivity cohort. ( 24367721 )
2013
47
Anaesthesia management in patients with multiple chemical sensitivity syndrome. ( 24355232 )
2013
48
Intranasal administration of hyaluronan as a further resource in olfactory performance in multiple chemical sensitivity syndrome. ( 24355241 )
2013
49
Women with multiple chemical sensitivity have increased harm avoidance and reduced 5-HT(1A) receptor binding potential in the anterior cingulate and amygdala. ( 23349968 )
2013
50
Evaluation of genetic polymorphisms in patients with multiple chemical sensitivity. ( 23967348 )
2013

Variations for Multiple Chemical Sensitivity

Expression for Multiple Chemical Sensitivity

Search GEO for disease gene expression data for Multiple Chemical Sensitivity.

Pathways for Multiple Chemical Sensitivity

Pathways related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 CYP2C19 CYP2C9 CYP2D6 GSTT1 NAT2 PON1
2
Show member pathways
12.83 CYP2C19 CYP2C9 CYP2D6 GSTT1 NAT2
3
Show member pathways
12.26 CYP2C19 CYP2C9 CYP2D6 GSTT1 NAT2
4 11.71 CYP2C19 CYP2C9 CYP2D6
5
Show member pathways
11.65 CYP2C19 CYP2C9
6
Show member pathways
11.51 CYP2C19 CYP2C9 CYP2D6
7
Show member pathways
11.47 CYP2D6 GSTT1
8
Show member pathways
11.47 CYP2C19 CYP2C9 PON1 PON2
9
Show member pathways
11.43 CYP2C19 CYP2C9 CYP2D6
10
Show member pathways
11.3 CYP2C19 CYP2C9
11
Show member pathways
11.3 CYP2C19 CYP2C9 CYP2D6
12 11.27 CYP2C19 CYP2C9
13 11.12 CYP2C19 CYP2D6
14 11.04 CYP2C19 CYP2C9
15
Show member pathways
11.02 CYP2C19 CYP2C9 CYP2D6
16
Show member pathways
10.96 CYP2C9 NAT2
17 10.89 CYP2C9 GSTT1
18
Show member pathways
10.78 CYP2C19 CYP2C9 CYP2D6 PON1
19 10.36 PON1 PON2

GO Terms for Multiple Chemical Sensitivity

Cellular components related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 9.13 CYP2C19 CYP2C9 CYP2D6
2 intracellular membrane-bounded organelle GO:0043231 9.02 CYP2C19 CYP2C9 CYP2D6 PON1 PON2

Biological processes related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.72 CYP2C9 CYP2D6 PON1
2 steroid metabolic process GO:0008202 9.67 CYP2C19 CYP2C9 CYP2D6
3 response to toxic substance GO:0009636 9.56 PON1 PON2
4 long-chain fatty acid biosynthetic process GO:0042759 9.54 CYP2C9 CYP2D6
5 epoxygenase P450 pathway GO:0019373 9.52 CYP2C19 CYP2C9
6 lipoxygenase pathway GO:0019372 9.51 PON1 PON2
7 drug metabolic process GO:0017144 9.5 CYP2C19 CYP2C9 CYP2D6
8 omega-hydroxylase P450 pathway GO:0097267 9.48 CYP2C19 CYP2C9
9 oxidative demethylation GO:0070989 9.46 CYP2C9 CYP2D6
10 heterocycle metabolic process GO:0046483 9.43 CYP2C19 CYP2D6
11 exogenous drug catabolic process GO:0042738 9.43 CYP2C19 CYP2C9 CYP2D6
12 drug catabolic process GO:0042737 9.4 CYP2C9 CYP2D6
13 aromatic compound catabolic process GO:0019439 9.37 PON1 PON2
14 organic acid metabolic process GO:0006082 9.33 CYP2C19 CYP2C9 CYP2D6
15 xenobiotic metabolic process GO:0006805 9.26 CYP2C19 CYP2C9 CYP2D6 NAT2
16 monoterpenoid metabolic process GO:0016098 8.8 CYP2C19 CYP2C9 CYP2D6

Molecular functions related to Multiple Chemical Sensitivity according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 CYP2C19 CYP2C9 CYP2D6
2 heme binding GO:0020037 9.61 CYP2C19 CYP2C9 CYP2D6
3 iron ion binding GO:0005506 9.58 CYP2C19 CYP2C9 CYP2D6
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.5 CYP2C19 CYP2C9 CYP2D6
5 drug binding GO:0008144 9.48 CYP2C9 CYP2D6
6 arachidonic acid epoxygenase activity GO:0008392 9.46 CYP2C19 CYP2C9
7 monooxygenase activity GO:0004497 9.43 CYP2C19 CYP2C9 CYP2D6
8 arylesterase activity GO:0004064 9.37 PON1 PON2
9 acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 9.16 PON1 PON2
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.13 CYP2C19 CYP2C9 CYP2D6
11 steroid hydroxylase activity GO:0008395 8.8 CYP2C19 CYP2C9 CYP2D6

Sources for Multiple Chemical Sensitivity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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