MFAB
MCID: MLT120
MIFTS: 22

Multiple Fibroadenomas of the Breast (MFAB)

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Multiple Fibroadenomas of the Breast

MalaCards integrated aliases for Multiple Fibroadenomas of the Breast:

Name: Multiple Fibroadenomas of the Breast 57 74 29 6 72
Mfab 57 74
Multiple Fibroadenoma of the Breast 59
Fibroadenomas, Breast, Multiple 40
Mammary Polyadenomatosis 59

Characteristics:

Orphanet epidemiological data:

59

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
multiple fibroadenomas of the breast:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 615554
MeSH 44 D018226
ICD10 via Orphanet 34 D24
Orphanet 59 ORPHA50920
UMLS 72 C3809918

Summaries for Multiple Fibroadenomas of the Breast

UniProtKB/Swiss-Prot : 74 Multiple fibroadenomas of the breast: A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.

MalaCards based summary : Multiple Fibroadenomas of the Breast, also known as mfab, is related to benign breast phyllodes tumor. An important gene associated with Multiple Fibroadenomas of the Breast is PRLR (Prolactin Receptor). Affiliated tissues include breast and neutrophil, and related phenotype is fibroadenoma of the breast.

OMIM : 57 Fibroadenoma represents a benign breast disease characterized by lobuloalveolar growth with abnormally high proliferation of the epithelium. Patients with more than 3 fibroadenomas in 1 breast are considered to have multiple fibroadenomas (summary by Bogorad et al., 2008). (615554)

Related Diseases for Multiple Fibroadenomas of the Breast

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Multiple Fibroadenomas of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 benign breast phyllodes tumor 10.0

Symptoms & Phenotypes for Multiple Fibroadenomas of the Breast

Human phenotypes related to Multiple Fibroadenomas of the Breast:

32
# Description HPO Frequency HPO Source Accession
1 fibroadenoma of the breast 32 HP:0010619

Symptoms via clinical synopsis from OMIM:

57
Chest Breasts:
more than 3 fibroadenomas in a single breast

Clinical features from OMIM:

615554

Drugs & Therapeutics for Multiple Fibroadenomas of the Breast

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of a New Design of Foot Abduction Brace (FAB) Compared to Standard FAB During Ponseti Treatment of Idiopathic Clubfoot by Measuring Rate of Recurrence and Compliance Using Novel Touch Sensors Recruiting NCT03249805

Search NIH Clinical Center for Multiple Fibroadenomas of the Breast

Genetic Tests for Multiple Fibroadenomas of the Breast

Genetic tests related to Multiple Fibroadenomas of the Breast:

# Genetic test Affiliating Genes
1 Multiple Fibroadenomas of the Breast 29 PRLR

Anatomical Context for Multiple Fibroadenomas of the Breast

MalaCards organs/tissues related to Multiple Fibroadenomas of the Breast:

41
Breast, Neutrophil

Publications for Multiple Fibroadenomas of the Breast

Articles related to Multiple Fibroadenomas of the Breast:

(show all 16)
# Title Authors PMID Year
1
Mutant prolactin receptor and familial hyperprolactinemia. 8 71
24195502 2013
2
Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors. 8 71
18779591 2008
3
Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation. 38
29210180 2018
4
An overview and comparison of a recombinant antigen-binding fragment and an antigen-binding fragment from a monoclonal antibody against wogonin glucuronide. 38
28623444 2017
5
Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp (Cyprinus carpio). 38
28030623 2016
6
The reliability and validity of the MATRICS functional assessment battery. 38
24214931 2014
7
Surgical management of multiple bilateral fibroadenoma of the breast: the Ribeiro technique modified by Rezai. 38
19596968 2009
8
Site-specific conjugation of HIV-1 tat peptides to IgG: a potential route to construct radioimmunoconjugates for targeting intracellular and nuclear epitopes in cancer. 38
16258763 2006
9
Carcinoma arising within fibroadenoma--a case report. 38
12583428 2000
10
Consecutively Occurring Multiple Fibroadenomas of the Breast Distinguished from Phyllodes Tumors by Clonality Analysis of Stromal Tissue. 38
11091716 1999
11
Cyclosporin A and multiple fibroadenomas of the breast. 38
9038560 1996
12
Multiple fibroadenomas of the breast: a problem of uncertain incidence and management. 38
8323208 1993
13
Differential roles of Fc gamma RII and Fc gamma RIII in immune complex stimulation of human neutrophils. 38
1328206 1992
14
Chromosome abnormalities in breast fibroadenomas. 38
1868034 1991
15
Familial bilateral multiple fibroadenomas of the breast. 38
4022881 1985
16
Necrosis in multiple fibroadenomas of the breast following pregnancy and lactation; report of a case. 38
18902814 1948

Variations for Multiple Fibroadenomas of the Breast

ClinVar genetic disease variations for Multiple Fibroadenomas of the Breast:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 PRLR NM_000949.7(PRLR): c.508A> C (p.Ile170Leu) single nucleotide variant Pathogenic rs72478580 5:35072712-35072712 5:35072610-35072610

UniProtKB/Swiss-Prot genetic disease variations for Multiple Fibroadenomas of the Breast:

74
# Symbol AA change Variation ID SNP ID
1 PRLR p.Ile170Leu VAR_070894 rs72478580

Expression for Multiple Fibroadenomas of the Breast

Search GEO for disease gene expression data for Multiple Fibroadenomas of the Breast.

Pathways for Multiple Fibroadenomas of the Breast

GO Terms for Multiple Fibroadenomas of the Breast

Sources for Multiple Fibroadenomas of the Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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