MCID: MLT011
MIFTS: 24

Multiple Mucosal Neuroma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Multiple Mucosal Neuroma

MalaCards integrated aliases for Multiple Mucosal Neuroma:

Name: Multiple Mucosal Neuroma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5155
NCIt 50 C6559
UMLS 70 C1334828

Summaries for Multiple Mucosal Neuroma

MalaCards based summary : Multiple Mucosal Neuroma is related to neuroma and thyroid carcinoma. An important gene associated with Multiple Mucosal Neuroma is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Calcium signaling pathway and Neuroscience. Affiliated tissues include thyroid, bone and small intestine.

Related Diseases for Multiple Mucosal Neuroma

Diseases related to Multiple Mucosal Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 neuroma 30.3 RET GDNF ENO2 CALCA
2 thyroid carcinoma 30.1 RET NTRK1 CALCA
3 multiple endocrine neoplasia 29.9 RET MEN1 GDNF CALCA
4 thyroid gland medullary carcinoma 29.3 RET NTRK1 MEN1 GDNF CALCA
5 thyroid carcinoma, familial medullary 29.3 RET NTRK1 MEN1 GDNF CALCA
6 multiple endocrine neoplasia, type iib 29.3 RET NTRK1 MEN1 GDNF CALCA
7 pheochromocytoma 28.8 RET NTRK1 MEN1 GDNF ENO2 CALCA
8 adrenal gland pheochromocytoma 10.3
9 nonencapsulated sclerosing carcinoma 10.2 RET CALCA
10 medullary sponge kidney 10.2 RET GDNF
11 hypoganglionosis 10.2 RET GDNF
12 skin lipoma 10.1 RET MEN1
13 esophagus leiomyoma 10.1 RET GDNF
14 patulous eustachian tube 10.1 GDNF CALCA
15 hyperparathyroidism 2 with jaw tumors 10.1 RET MEN1
16 nodular goiter 10.1 RET CALCA
17 endocrine pancreas disease 10.1 MEN1 CALCA
18 goldberg-shprintzen syndrome 10.1 RET GDNF
19 pancreatic cholera 10.1 MEN1 CALCA
20 cerebellar angioblastoma 10.1 MEN1 CALCA
21 neuronal intestinal dysplasia, type b 10.1 RET ENO2
22 renal hypoplasia 10.1 RET GDNF
23 multiple endocrine neoplasia, type iv 10.1 RET MEN1
24 persistent generalized lymphadenopathy 10.1 RET MEN1
25 carotid body cancer 10.1 ENO2 CALCA
26 vipoma 10.1 MEN1 CALCA
27 paraganglioma and gastric stromal sarcoma 10.1 RET MEN1
28 nasal cavity olfactory neuroblastoma 10.1 ENO2 CALCA
29 intestinal obstruction 10.0 RET GDNF
30 sclerosing hemangioma 10.0 ENO2 CALCA
31 bone benign neoplasm 10.0 ENO2 CALCA
32 mineral metabolism disease 10.0 MEN1 CALCA
33 gastric gastrinoma 10.0 MEN1 ENO2
34 malignant pheochromocytoma 10.0 ENO2 CALCA
35 hereditary paraganglioma-pheochromocytoma syndromes 10.0 RET GDNF
36 carney complex variant 10.0 RET MEN1
37 causalgia 10.0
38 gastrointestinal neuroendocrine tumor 10.0 MEN1 ENO2
39 carcinoid tumors, intestinal 10.0 MEN1 ENO2
40 tall cell variant papillary carcinoma 10.0 RET NTRK1
41 small intestine benign neoplasm 10.0 MEN1 ENO2
42 clear cell ependymoma 10.0 MEN1 ENO2
43 pulmonary neuroendocrine tumor 10.0 MEN1 ENO2
44 neurogenic arthropathy 10.0 NTRK1 CALCA
45 familial hypocalciuric hypercalcemia 10.0 RET MEN1 CALCA
46 parathyroid gland disease 10.0 RET MEN1 CALCA
47 parathyroid carcinoma 10.0 RET MEN1 CALCA
48 parathyroid adenoma 9.9 RET MEN1 CALCA
49 spitzoid melanoma 9.9 RET NTRK1
50 benign struma ovarii 9.9 RET NTRK1

Graphical network of the top 20 diseases related to Multiple Mucosal Neuroma:



Diseases related to Multiple Mucosal Neuroma

Symptoms & Phenotypes for Multiple Mucosal Neuroma

Drugs & Therapeutics for Multiple Mucosal Neuroma

Search Clinical Trials , NIH Clinical Center for Multiple Mucosal Neuroma

Genetic Tests for Multiple Mucosal Neuroma

Anatomical Context for Multiple Mucosal Neuroma

MalaCards organs/tissues related to Multiple Mucosal Neuroma:

40
Thyroid, Bone, Small Intestine, Kidney, Pancreas, Adrenal Gland, Skin

Publications for Multiple Mucosal Neuroma

Articles related to Multiple Mucosal Neuroma:

(show all 17)
# Title Authors PMID Year
1
IMAGES IN CLINICAL MEDICINE. Multiple Mucosal Neuroma. 61
26287851 2015
2
[Clinicopathological features of multiple mucosal neuroma without multiple endocrine neoplasia type IIB]. 61
22169552 2011
3
Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA Analysis. 61
21165219 2010
4
Multiple mucosal neuroma syndrome. 61
20921677 1999
5
[Solitary encapsulated neuroma]. 61
2276917 1990
6
Palisaded encapsulated neuromas. A clinicopathologic study. 61
2923447 1989
7
Visible corneal nerve fibers and neuromas of the conjunctiva--a syndrome of type-3 multiple endocrine adenomatosis in two generations. 61
2886402 1987
8
Colonic ganglioneuroma. 61
7350889 1980
9
Multiple mucosal neuroma (MMN) or multiple endocrine neoplasia (MEN) type 3 syndrome. Ocular manifestations: a case report. 61
923405 1977
10
Familial cancer syndromes: a survey. 61
404022 1977
11
[A syndrome of multiple mucosal neuroma, medullary thyroid carcinoma and pheochromocytoma: report of a case (author's transl)]. 61
558452 1977
12
[A syndrome of multiple neuromas with metastasizing medullary thyroid carcinoma. ("Multiple mucosal neuroma" syndrome)]. 61
860540 1977
13
[Syndrome of multiple neuromas. ("Multiple mucosal neuroma" syndrome)]. 61
860541 1977
14
Letter: Multiple mucosal neuroma syndrome. 61
1147648 1975
15
[Multiple mucosal neuroma syndrome]. 61
1224406 1975
16
Letter: Mucosal neuroma syndrome: pheochromocytoma and MCT syndrome: and pheochromocytoma and McT with multiple mucosal neuroma syndrome: one or more syndromes? 61
4826737 1974
17
Pheochromocytoma, medullary thyroid carcinoma, multiple mucosal neuroma. A variant of the syndrome. 61
4623875 1972

Variations for Multiple Mucosal Neuroma

Expression for Multiple Mucosal Neuroma

Search GEO for disease gene expression data for Multiple Mucosal Neuroma.

Pathways for Multiple Mucosal Neuroma

Pathways related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 RET NTRK1 GDNF
2 11.46 RET NTRK1 ENO2 CALCA
3 10.74 RET GDNF
4 9.73 RET GDNF

GO Terms for Multiple Mucosal Neuroma

Cellular components related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.96 SLC18A1 CALCA
2 neuronal cell body GO:0043025 8.92 RET NTRK1 ENO2 CALCA

Biological processes related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.63 RET MEN1 GDNF
2 axon guidance GO:0007411 9.54 RET NTRK1 GDNF
3 neural crest cell migration GO:0001755 9.48 RET GDNF
4 cellular response to nerve growth factor stimulus GO:1990090 9.43 NTRK1 CALCA
5 ureteric bud development GO:0001657 9.4 RET GDNF
6 innervation GO:0060384 9.32 RET NTRK1
7 response to pain GO:0048265 9.26 RET CALCA
8 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.16 NTRK1 CALCA
9 sympathetic nervous system development GO:0048485 8.96 NTRK1 GDNF
10 enteric nervous system development GO:0048484 8.62 RET GDNF

Molecular functions related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 RET NTRK1

Sources for Multiple Mucosal Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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