MCID: MLT011
MIFTS: 26

Multiple Mucosal Neuroma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Multiple Mucosal Neuroma

MalaCards integrated aliases for Multiple Mucosal Neuroma:

Name: Multiple Mucosal Neuroma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5155
NCIt 51 C6559
UMLS 74 C1334828

Summaries for Multiple Mucosal Neuroma

MalaCards based summary : Multiple Mucosal Neuroma is related to neuroma and thyroid carcinoma, familial medullary. An important gene associated with Multiple Mucosal Neuroma is ENO2 (Enolase 2), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include lung, thyroid and ovary.

Related Diseases for Multiple Mucosal Neuroma

Diseases related to Multiple Mucosal Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 neuroma 30.7 ENO2 RET
2 thyroid carcinoma, familial medullary 30.1 ENO2 RET
3 pheochromocytoma 29.8 ENO2 NCAM1 RET
4 multiple endocrine neoplasia, type iib 11.7
5 multiple endocrine neoplasia 10.2
6 thyroid cancer 10.2
7 gastric leiomyosarcoma 10.1 ENO2 KIT
8 leiomyosarcoma 10.1 ENO2 KIT
9 plexiform schwannoma 10.1 ENO2 KIT
10 conventional fibrosarcoma 10.1 ENO2 KIT
11 rete testis adenocarcinoma 10.1 ENO2 KIT
12 prostate small cell carcinoma 10.1 ENO2 KIT
13 heart sarcoma 10.1 ENO2 KIT
14 muscular atrophy 10.1
15 mixed cell type cancer 10.1 ENO2 KIT
16 dysgerminoma of ovary 10.1 ENO2 KIT
17 dysgerminoma 10.1 ENO2 KIT
18 central nervous system melanocytic neoplasm 10.1 ENO2 KIT
19 muscle cancer 10.0 ENO2 KIT
20 connective tissue cancer 10.0 ENO2 KIT
21 neurilemmoma 10.0 ENO2 KIT
22 clear cell sarcoma 10.0 ENO2 KIT
23 adenosquamous lung carcinoma 10.0 ENO2 RET
24 teratoma 10.0 ENO2 KIT
25 seminoma 10.0 ENO2 KIT
26 neurofibromatosis, type iv, of riccardi 10.0 KIT RET
27 lung meningioma 9.9 ENO2 NCAM1
28 extrahepatic bile duct adenocarcinoma 9.9 ENO2 NCAM1
29 choriocarcinoma of ovary 9.9 ENO2 NCAM1
30 orbital cancer 9.9 ENO2 NCAM1
31 gallbladder small cell carcinoma 9.9 ENO2 NCAM1
32 paraganglioma 9.9 ENO2 RET
33 middle cerebral artery infarction 9.9 ENO2 NCAM1
34 mediastinal cancer 9.9 KIT NCAM1
35 cervical clear cell adenocarcinoma 9.9 ENO2 NCAM1
36 gastric small cell carcinoma 9.9 ENO2 NCAM1
37 subependymoma 9.9 ENO2 NCAM1
38 gastric squamous cell carcinoma 9.9 ENO2 NCAM1
39 helsmoortel-van der aa syndrome 9.9 KIT NCAM1
40 perineurioma 9.9 KIT NCAM1
41 cervix small cell carcinoma 9.9 ENO2 NCAM1
42 neurofibromatosis, type i 9.9 KIT NCAM1
43 malignant skin fibrous histiocytoma 9.9 KIT NCAM1
44 cranial nerve malignant neoplasm 9.9 ENO2 NCAM1
45 myeloid sarcoma 9.9 KIT NCAM1
46 malignant dermis tumor 9.9 KIT NCAM1
47 mixed ductal-endocrine carcinoma 9.9 ENO2 NCAM1
48 ileum cancer 9.9 ENO2 NCAM1
49 constipation 9.9 KIT RET
50 malignant mesenchymoma 9.9 KIT NCAM1

Graphical network of the top 20 diseases related to Multiple Mucosal Neuroma:



Diseases related to Multiple Mucosal Neuroma

Symptoms & Phenotypes for Multiple Mucosal Neuroma

Drugs & Therapeutics for Multiple Mucosal Neuroma

Search Clinical Trials , NIH Clinical Center for Multiple Mucosal Neuroma

Genetic Tests for Multiple Mucosal Neuroma

Anatomical Context for Multiple Mucosal Neuroma

MalaCards organs/tissues related to Multiple Mucosal Neuroma:

42
Lung, Thyroid, Ovary, Testis, Skin, Heart, Prostate

Publications for Multiple Mucosal Neuroma

Articles related to Multiple Mucosal Neuroma:

# Title Authors Year
1
IMAGES IN CLINICAL MEDICINE. Multiple Mucosal Neuroma. ( 26287851 )
2015
2
Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA Analysis. ( 21165219 )
2010
3
Multiple mucosal neuroma syndrome. ( 20921677 )
1999
4
Multiple mucosal neuroma (MMN) or multiple endocrine neoplasia (MEN) type 3 syndrome. Ocular manifestations: a case report. ( 923405 )
1977
5
Letter: Multiple mucosal neuroma syndrome. ( 1147648 )
1975
6
Letter: Mucosal neuroma syndrome: pheochromocytoma and MCT syndrome: and pheochromocytoma and McT with multiple mucosal neuroma syndrome: one or more syndromes? ( 4826737 )
1974
7
Pheochromocytoma, medullary thyroid carcinoma, multiple mucosal neuroma. A variant of the syndrome. ( 4623875 )
1972

Variations for Multiple Mucosal Neuroma

Expression for Multiple Mucosal Neuroma

Search GEO for disease gene expression data for Multiple Mucosal Neuroma.

Pathways for Multiple Mucosal Neuroma

GO Terms for Multiple Mucosal Neuroma

Biological processes related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.37 KIT RET
2 positive regulation of protein kinase B signaling GO:0051897 9.32 KIT RET
3 positive regulation of MAPK cascade GO:0043410 9.26 KIT RET
4 activation of MAPK activity GO:0000187 9.16 KIT RET
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 KIT RET
6 MAPK cascade GO:0000165 8.8 KIT NCAM1 RET

Molecular functions related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.96 KIT RET
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 KIT RET

Sources for Multiple Mucosal Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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