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MCID: MLT011
MIFTS: 23

Multiple Mucosal Neuroma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Multiple Mucosal Neuroma

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MalaCards integrated aliases for Multiple Mucosal Neuroma:

Name: Multiple Mucosal Neuroma 12 15

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5155
NCIt 49 C6559
UMLS 71 C1334828
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Summaries for Multiple Mucosal Neuroma

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MalaCards based summary : Multiple Mucosal Neuroma is related to multiple endocrine neoplasia, type iib and multiple endocrine neoplasia. An important gene associated with Multiple Mucosal Neuroma is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Neuroscience and Central carbon metabolism in cancer. Affiliated tissues include thyroid and colon.

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Related Diseases for Multiple Mucosal Neuroma

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Diseases related to Multiple Mucosal Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 multiple endocrine neoplasia, type iib 31.1 SDHAF2 RET NTRK1 GDNF CALCA
2 multiple endocrine neoplasia 30.5 RET GDNF CALCA
3 thyroid carcinoma 30.1 RET NTRK1 CALCA
4 neuroma 30.0 RET GDNF ENO2 CALCA
5 intestinal obstruction 29.9 RET GDNF
6 constipation 29.7 RET GDNF CALCA
7 thyroid gland medullary carcinoma 29.6 RET NTRK1 GDNF CALCA
8 thyroid carcinoma, familial medullary 29.6 RET NTRK1 GDNF CALCA
9 megacolon 29.3 RET NTRK1 GDNF
10 pheochromocytoma 28.4 SDHAF2 RET NTRK1 GDNF ENO2 CALCA
11 adrenal gland pheochromocytoma 10.5
12 nonencapsulated sclerosing carcinoma 10.3 RET CALCA
13 medullary sponge kidney 10.2 RET GDNF
14 hypoganglionosis 10.2 RET GDNF
15 nodular goiter 10.2 RET CALCA
16 goldberg-shprintzen syndrome 10.2 RET GDNF
17 parathyroid carcinoma 10.1 RET CALCA
18 autoimmune disease of endocrine system 10.1 RET CALCA
19 extra-adrenal pheochromocytoma 10.1 SDHAF2 RET
20 adrenal medulla cancer 10.1 SDHAF2 RET
21 parathyroid gland disease 10.1 RET CALCA
22 persistent generalized lymphadenopathy 10.1 SDHAF2 RET
23 epicondylitis 10.1 PES1 CALCA
24 muscular atrophy 10.1
25 multinodular goiter 10.1 RET CALCA
26 paraganglioma and gastric stromal sarcoma 10.1 SDHAF2 RET
27 ureter small cell carcinoma 10.1 ENO2 CALCA
28 small cell carcinoma 10.1 ENO2 CALCA
29 carotid body cancer 10.1 ENO2 CALCA
30 ischemic bone disease 10.1 PES1 CALCA
31 lung oat cell carcinoma 10.0 ENO2 CALCA
32 exostosis 10.0 PES1 CALCA
33 carcinoid syndrome 10.0 ENO2 CALCA
34 colon neuroendocrine neoplasm 10.0 ENO2 CALCA
35 nasal cavity olfactory neuroblastoma 10.0 ENO2 CALCA
36 sclerosing hemangioma 10.0 ENO2 CALCA
37 somatostatinoma 10.0 ENO2 CALCA
38 lymph node disease 10.0 SDHAF2 RET
39 malignant pheochromocytoma 10.0 ENO2 CALCA
40 central nervous system benign neoplasm 10.0 RET ENO2
41 causalgia 9.9
42 neurofibroma 9.9
43 thyroiditis 9.9 RET CALCA
44 tall cell variant papillary carcinoma 9.9 RET NTRK1
45 thymic carcinoma 9.9 ENO2 CALCA
46 neurogenic arthropathy 9.9 NTRK1 CALCA
47 spitzoid melanoma 9.9 RET NTRK1
48 hypertrophic pyloric stenosis 9.9 RET NTRK1
49 alternating hemiplegia of childhood 9.9 PES1 CALCA
50 esophagus leiomyoma 9.8 SDHAF2 RET GDNF

Graphical network of the top 20 diseases related to Multiple Mucosal Neuroma:



Diseases related to Multiple Mucosal Neuroma
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Symptoms & Phenotypes for Multiple Mucosal Neuroma

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Drugs & Therapeutics for Multiple Mucosal Neuroma

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Search Clinical Trials , NIH Clinical Center for Multiple Mucosal Neuroma

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Genetic Tests for Multiple Mucosal Neuroma

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Anatomical Context for Multiple Mucosal Neuroma

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MalaCards organs/tissues related to Multiple Mucosal Neuroma:

40
Thyroid, Colon
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Publications for Multiple Mucosal Neuroma

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Articles related to Multiple Mucosal Neuroma:

(show all 17)
# Title Authors PMID Year
1
IMAGES IN CLINICAL MEDICINE. Multiple Mucosal Neuroma. 61
26287851 2015
2
[Clinicopathological features of multiple mucosal neuroma without multiple endocrine neoplasia type IIB]. 61
22169552 2011
3
Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA Analysis. 61
21165219 2010
4
Multiple mucosal neuroma syndrome. 61
20921677 1999
5
[Solitary encapsulated neuroma]. 61
2276917 1990
6
Palisaded encapsulated neuromas. A clinicopathologic study. 61
2923447 1989
7
Visible corneal nerve fibers and neuromas of the conjunctiva--a syndrome of type-3 multiple endocrine adenomatosis in two generations. 61
2886402 1987
8
Colonic ganglioneuroma. 61
7350889 1980
9
Multiple mucosal neuroma (MMN) or multiple endocrine neoplasia (MEN) type 3 syndrome. Ocular manifestations: a case report. 61
923405 1977
10
Familial cancer syndromes: a survey. 61
404022 1977
11
[A syndrome of multiple neuromas with metastasizing medullary thyroid carcinoma. ("Multiple mucosal neuroma" syndrome)]. 61
860540 1977
12
[A syndrome of multiple mucosal neuroma, medullary thyroid carcinoma and pheochromocytoma: report of a case (author's transl)]. 61
558452 1977
13
[Syndrome of multiple neuromas. ("Multiple mucosal neuroma" syndrome)]. 61
860541 1977
14
Letter: Multiple mucosal neuroma syndrome. 61
1147648 1975
15
[Multiple mucosal neuroma syndrome]. 61
1224406 1975
16
Letter: Mucosal neuroma syndrome: pheochromocytoma and MCT syndrome: and pheochromocytoma and McT with multiple mucosal neuroma syndrome: one or more syndromes? 61
4826737 1974
17
Pheochromocytoma, medullary thyroid carcinoma, multiple mucosal neuroma. A variant of the syndrome. 61
4623875 1972
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Variations for Multiple Mucosal Neuroma

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Expression for Multiple Mucosal Neuroma

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Search GEO for disease gene expression data for Multiple Mucosal Neuroma.
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Pathways for Multiple Mucosal Neuroma

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Pathways related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.46 RET NTRK1 ENO2 CALCA
2
Central carbon metabolism in cancer 36
11.1 RET NTRK1
3
Signaling events regulated by Ret tyrosine kinase 1
10.54 RET GDNF
4
RNAi Pathway 63
9.63 RET GDNF
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GO Terms for Multiple Mucosal Neuroma

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Cellular components related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.13 RET NTRK1 CALCA
2 neuronal cell body GO:0043025 8.92 RET NTRK1 ENO2 CALCA

Biological processes related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.54 RET NTRK1 GDNF
2 neural crest cell migration GO:0001755 9.46 RET GDNF
3 ureteric bud development GO:0001657 9.43 RET GDNF
4 cellular response to nerve growth factor stimulus GO:1990090 9.4 NTRK1 CALCA
5 innervation GO:0060384 9.32 RET NTRK1
6 response to pain GO:0048265 9.26 RET CALCA
7 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.16 NTRK1 CALCA
8 sympathetic nervous system development GO:0048485 8.96 NTRK1 GDNF
9 enteric nervous system development GO:0048484 8.62 RET GDNF

Molecular functions related to Multiple Mucosal Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 RET NTRK1
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Sources for Multiple Mucosal Neuroma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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