MCID: MLT093
MIFTS: 20

Multiple Sclerosis 2

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Multiple Sclerosis 2

MalaCards integrated aliases for Multiple Sclerosis 2:

Name: Multiple Sclerosis 2 57
Multiple Sclerosis, Susceptibility to, 2 57 13
Ms2 57

Classifications:



External Ids:

OMIM 57 612594

Summaries for Multiple Sclerosis 2

MalaCards based summary : Multiple Sclerosis 2, also known as multiple sclerosis, susceptibility to, 2, is related to multiple sclerosis and hepatitis. An important gene associated with Multiple Sclerosis 2 is MS2 (Multiple Sclerosis, Susceptibility To, 2). The drugs Autonomic Agents and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial.

Description from OMIM: 612594

Related Diseases for Multiple Sclerosis 2

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2 Multiple Sclerosis 3
Multiple Sclerosis 4 Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 11.1
2 hepatitis 9.9
3 hepatitis e 9.9

Symptoms & Phenotypes for Multiple Sclerosis 2

Clinical features from OMIM:

612594

Drugs & Therapeutics for Multiple Sclerosis 2

Drugs for Multiple Sclerosis 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
2 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic beta-2 Receptor Agonists Phase 4
6 Adrenergic beta-Agonists Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Bronchodilator Agents Phase 4
9 Neurotransmitter Agents Phase 4,Not Applicable
10 Respiratory System Agents Phase 4
11
Salmeterol xinafoate Phase 4 94749-08-3 56801
12
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
13
Lenalidomide Approved Phase 3 191732-72-6 216326
14
Dimethyl fumarate Approved, Investigational Phase 3 624-49-7 5271565 637568
15 Antiemetics Phase 3,Phase 2
16 Anti-Inflammatory Agents Phase 3,Phase 2
17 Antineoplastic Agents, Hormonal Phase 3,Phase 2
18 BB 1101 Phase 3,Phase 2
19 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
20 Gastrointestinal Agents Phase 3,Phase 2
21 glucocorticoids Phase 3,Phase 2
22 HIV Protease Inhibitors Phase 3,Phase 2
23 Hormone Antagonists Phase 3,Phase 2
24 Hormones Phase 3,Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
26 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
27
protease inhibitors Phase 3,Phase 2
28 Angiogenesis Inhibitors Phase 3
29 Angiogenesis Modulating Agents Phase 3
30 Anti-Bacterial Agents Phase 3
31 Anti-Infective Agents Phase 3
32 Dermatologic Agents Phase 3
33
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
34
Angiotensin II Approved, Investigational Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
35
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
36 Alkylating Agents Phase 1, Phase 2
37 Antineoplastic Agents, Alkylating Phase 1, Phase 2
38 Antirheumatic Agents Phase 1, Phase 2
39 Bendamustine Hydrochloride Phase 1, Phase 2
40 Vaccines Phase 2
41 Angiotensin II Type 1 Receptor Blockers Phase 2
42 Angiotensin Receptor Antagonists Phase 2
43 Angiotensinogen Phase 2
44 Antihypertensive Agents Phase 2
45 LCZ 696 Phase 2
46
Menthol Approved Not Applicable 2216-51-5 16666
47
Nicotine Approved Not Applicable 54-11-5 942 89594
48
Coenzyme Q10 Approved, Investigational, Nutraceutical Early Phase 1 303-98-0 5281915
49
Tocopherol Approved, Investigational, Nutraceutical Early Phase 1 1406-66-2 14986
50
Vitamin C Approved, Nutraceutical Early Phase 1 50-81-7 5785 54670067

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure Completed NCT02903225 Phase 4
2 Effects of Salmeterol on Autonomic Nervous System Completed NCT01536587 Phase 4 Salmeterol
3 A Multicenter, Single-Arm, Open-Label Expanded Access Program for Lenalidomide Plus Dexamethasone in Previously Treated Subjects With Multiple Myeloma Completed NCT00478777 Phase 3 Lenalidomide;dexamethasone
4 A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2 Recruiting NCT03093324 Phase 3 ALKS 8700;Dimethyl Fumarate
5 Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults Unknown status NCT00548483 Phase 2 dexamethasone (Oradexon, Nederland)
6 Dexamethasone and the Prevention of Post-Extubation Airway Obstruction in Adults Unknown status NCT00452062 Phase 2 Dexamethasone
7 Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes Unknown status NCT02134262 Phase 1, Phase 2 Cyclophosphamide or Bendamustine
8 Impaired Immunity in Patients With Cancer: Influence of Cancer Stage, Chemotherapy, and Cytomegalovirus Infection Unknown status NCT00521287 Phase 2
9 High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome Unknown status NCT02924831 Phase 2
10 Influences of Angiotensin-neprilysin Inhibition on Sympathetic Activity in Heart Failure Not yet recruiting NCT03415906 Phase 2 valsartan
11 Immune-Related Trafficking and Signaling in Human Skin Associated With Low-Power, Infrared Laser Treatment Recruiting NCT02453113 Phase 1
12 Physical Telerehabilitation in Veterans With Multiple Sclerosis Completed NCT02346734 Not Applicable
13 Basic Life Support Cardiopulmonary Resuscitation Refresher in MS2 at St George's University Completed NCT01832012 Not Applicable
14 Quantification of Autonomic Nervous Activity During Hemodialysis Completed NCT02754986 Not Applicable
15 Behavioral Neurocardiac Training and Hypertension Completed NCT00811811 Not Applicable
16 The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction Completed NCT02919488 Not Applicable
17 The Effects of Vibration on Hypoxia Completed NCT01245491 Not Applicable
18 Mandible and Sub-mandible Using the 1440nm Wavelength Laser and Hand Piece Completed NCT01813747 Not Applicable
19 Respiratory and Autonomic Plasticity Following Intermittent Hypoxia Completed NCT00860743 Early Phase 1 Antioxidant cocktail
20 Obesity and Brain: Genes and Environment Completed NCT02025595
21 Study of Human Epidermal Growth Receptor (HER2) Status Evaluation in Breast Cancer Pathology Samples Completed NCT02580799
22 Heartrate Variability During Conventional and Variable Pressure Support Mechanical Ventilation Recruiting NCT03360968 Not Applicable
23 The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters Recruiting NCT03037775 Not Applicable
24 Immediate and Chronic Effects of Whole-Body Vibration on Neuromuscular Performance and Postural Control in Elderly Recruiting NCT03253042 Not Applicable
25 Immediate Effects of Whole-Body Vibration on Neuromuscular Performance and Postural Control in Elderly Recruiting NCT03356418 Not Applicable
26 HIRREM Developmental Study Recruiting NCT02709369 Not Applicable
27 Effects of TENS and IES on the Autonomous Balance of Normotens Volunteers and Hypertensive Patients Recruiting NCT03258489 Not Applicable
28 Effects of Massage in Different Moments of Application on Autonomic Cardiac Modulation and Cardiorespiratory Parameters Recruiting NCT03094676 Not Applicable
29 19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome Recruiting NCT03445962
30 Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation Recruiting NCT03373526 Not Applicable
31 HIRREM in Military Personnel Recruiting NCT03230890 Not Applicable
32 Pregnancy Related Inappropriate Sinus Tachycardia Active, not recruiting NCT03317249
33 Metabolism and the Activity of the Autonomic Nervous System in Patients With Paroxystic Sympathetic Hyperactivity, PSH Active, not recruiting NCT03441009
34 Yoga Poses and Breath Control Cardiovascular Changes in Hypertensive Post-Menopause Women Enrolling by invitation NCT03137849 Not Applicable
35 Evaluation of Autonomic Modulation in Stroke After Transcranial Direct Current Stimulation and Treadmill Training Not yet recruiting NCT02956096 Not Applicable
36 Epidemiological Analysis for Hereditary Angioedema Disease (EHA Study) Not yet recruiting NCT03558009
37 Passive Leg Raising - an Important Diagnostic Manoeuvre Not yet recruiting NCT03454802 Not Applicable
38 Myocardial Damage and Music Study Not yet recruiting NCT03507361 Not Applicable
39 HRV Biofeedback for Brain Tumour Survivors Suspended NCT01772498 Not Applicable

Search NIH Clinical Center for Multiple Sclerosis 2

Genetic Tests for Multiple Sclerosis 2

Anatomical Context for Multiple Sclerosis 2

MalaCards organs/tissues related to Multiple Sclerosis 2:

41
Brain, Heart, Endothelial, Skin, B Cells

Publications for Multiple Sclerosis 2

Variations for Multiple Sclerosis 2

Expression for Multiple Sclerosis 2

Search GEO for disease gene expression data for Multiple Sclerosis 2.

Pathways for Multiple Sclerosis 2

GO Terms for Multiple Sclerosis 2

Sources for Multiple Sclerosis 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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