MS3
MCID: MLT094
MIFTS: 22

Multiple Sclerosis 3 (MS3)

Categories: Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Multiple Sclerosis 3

MalaCards integrated aliases for Multiple Sclerosis 3:

Name: Multiple Sclerosis 3 58 76
Multiple Sclerosis, Susceptibility to, 3 58 13
Ms3 58 76

Classifications:



External Ids:

OMIM 58 612595
MeSH 45 D009103
MedGen 43 C2675477

Summaries for Multiple Sclerosis 3

UniProtKB/Swiss-Prot : 76 Multiple sclerosis 3: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

MalaCards based summary : Multiple Sclerosis 3, also known as multiple sclerosis, susceptibility to, 3, is related to heavy chain disease and multiple sclerosis. An important gene associated with Multiple Sclerosis 3 is MS3 (Multiple Sclerosis, Susceptibility To, 3). The drugs Docetaxel and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include monocytes, prostate and breast.

Description from OMIM: 612595

Related Diseases for Multiple Sclerosis 3

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2 Multiple Sclerosis 3
Multiple Sclerosis 4 Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 heavy chain disease 10.2
2 multiple sclerosis 10.0

Symptoms & Phenotypes for Multiple Sclerosis 3

Clinical features from OMIM:

612595

Drugs & Therapeutics for Multiple Sclerosis 3

Drugs for Multiple Sclerosis 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
2 Vaccines Phase 1
3 Immunologic Factors Phase 1
4 Antimitotic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autologous Tumor DRibble Vaccine in Patients With Non-Small Cell Lung Cancer Completed NCT00850785 Phase 1
2 The Value of MultiSpectral 3 Tesla MRI in Active Surveillance of Prostate Cancer Completed NCT01896713 Not Applicable
3 Study of Human Epidermal Growth Receptor (HER2) Status Evaluation in Breast Cancer Pathology Samples Completed NCT02580799
4 Prostate Screening Study Using MRI in BRCA Carriers Recruiting NCT01990521 Not Applicable

Search NIH Clinical Center for Multiple Sclerosis 3

Genetic Tests for Multiple Sclerosis 3

Anatomical Context for Multiple Sclerosis 3

MalaCards organs/tissues related to Multiple Sclerosis 3:

42
Monocytes, Prostate, Breast

Publications for Multiple Sclerosis 3

Articles related to Multiple Sclerosis 3:

# Title Authors Year
1
Long-term efficacy and safety of fingolimod in Japanese patients with relapsing multiple sclerosis: 3-year results of the phase 2 extension study. ( 28129749 )
2017
2
Safety and efficacy of daclizumab in relapsing-remitting multiple sclerosis: 3-year results from the SELECTED open-label extension study. ( 27461166 )
2016
3
Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. ( 22045554 )
2012
4
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results. ( 20028707 )
2010
5
The management of multiple sclerosis. 3. Apparent suppression of symptoms by an estrogen-progestin compound. ( 5766630 )
1969
6
Studies on the natural history of multiple sclerosis. 3. Epidemiologic analysis of the army experience in World War II. ( 5333273 )
1967
7
STUDIES ON THE PATHOGENESIS OF MULTIPLE SCLEROSIS. 3. DISSEMINATED INFARCTIONS OF THE CEREBRAL CENTRUM. ( 14325343 )
1965

Variations for Multiple Sclerosis 3

Expression for Multiple Sclerosis 3

Search GEO for disease gene expression data for Multiple Sclerosis 3.

Pathways for Multiple Sclerosis 3

GO Terms for Multiple Sclerosis 3

Sources for Multiple Sclerosis 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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