MCID: MLT094
MIFTS: 22

Multiple Sclerosis 3

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Multiple Sclerosis 3

MalaCards integrated aliases for Multiple Sclerosis 3:

Name: Multiple Sclerosis 3 57 75
Multiple Sclerosis, Susceptibility to, 3 57 13
Ms3 57 75

Classifications:



External Ids:

OMIM 57 612595
MedGen 42 C2675477
MeSH 44 D009103

Summaries for Multiple Sclerosis 3

UniProtKB/Swiss-Prot : 75 Multiple sclerosis 3: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

MalaCards based summary : Multiple Sclerosis 3, also known as multiple sclerosis, susceptibility to, 3, is related to multiple sclerosis and cerebritis. An important gene associated with Multiple Sclerosis 3 is MS3 (Multiple Sclerosis, Susceptibility To, 3). The drugs Docetaxel and Antimitotic Agents have been mentioned in the context of this disorder. Affiliated tissues include monocytes, prostate and lung.

Description from OMIM: 612595

Related Diseases for Multiple Sclerosis 3

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2 Multiple Sclerosis 3
Multiple Sclerosis 4 Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 28.3 IL7R MS3
2 cerebritis 9.6

Symptoms & Phenotypes for Multiple Sclerosis 3

Clinical features from OMIM:

612595

Drugs & Therapeutics for Multiple Sclerosis 3

Drugs for Multiple Sclerosis 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docetaxel Approved, Investigational Phase 1 114977-28-5 148124
2 Antimitotic Agents Phase 1
3 Vaccines Phase 1
4
Menthol Approved Not Applicable 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autologous Tumor DRibble Vaccine in Patients With Non-Small Cell Lung Cancer Completed NCT00850785 Phase 1
2 Exploring the Experience of Communication for Patients With Depression Unknown status NCT01727674
3 The Value of MultiSpectral 3 Tesla MRI in Active Surveillance of Prostate Cancer Completed NCT01896713 Not Applicable
4 Study of Human Epidermal Growth Receptor (HER2) Status Evaluation in Breast Cancer Pathology Samples Completed NCT02580799
5 Prostate Screening Study Using MRI in BRCA Carriers Recruiting NCT01990521 Not Applicable
6 A Longitudinal Study of Cancer-related Fatigue Among Colorectal Cancer Patients During Adjuvant Chemotherapy Recruiting NCT03013972

Search NIH Clinical Center for Multiple Sclerosis 3

Genetic Tests for Multiple Sclerosis 3

Anatomical Context for Multiple Sclerosis 3

MalaCards organs/tissues related to Multiple Sclerosis 3:

41
Monocytes, Prostate, Lung

Publications for Multiple Sclerosis 3

Articles related to Multiple Sclerosis 3:

# Title Authors Year
1
Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. ( 22045554 )
2012
2
The management of multiple sclerosis. 3. Apparent suppression of symptoms by an estrogen-progestin compound. ( 5766630 )
1969
3
Studies on the natural history of multiple sclerosis. 3. Epidemiologic analysis of the army experience in World War II. ( 5333273 )
1967
4
STUDIES ON THE PATHOGENESIS OF MULTIPLE SCLEROSIS. 3. DISSEMINATED INFARCTIONS OF THE CEREBRAL CENTRUM. ( 14325343 )
1965

Variations for Multiple Sclerosis 3

Expression for Multiple Sclerosis 3

Search GEO for disease gene expression data for Multiple Sclerosis 3.

Pathways for Multiple Sclerosis 3

GO Terms for Multiple Sclerosis 3

Sources for Multiple Sclerosis 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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