MCID: MLT124
MIFTS: 19

Multiple Sclerosis 5

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Multiple Sclerosis 5

MalaCards integrated aliases for Multiple Sclerosis 5:

Name: Multiple Sclerosis 5 57 75
Multiple Sclerosis, Susceptibility to, 5 57 29 13 6
Ms5 57 75
Multiple Sclerosis Susceptibility to, Type 5 40

Classifications:



External Ids:

OMIM 57 614810
MeSH 44 D009103

Summaries for Multiple Sclerosis 5

UniProtKB/Swiss-Prot : 75 Multiple sclerosis 5: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

MalaCards based summary : Multiple Sclerosis 5, also known as multiple sclerosis, susceptibility to, 5, is related to neuronitis. An important gene associated with Multiple Sclerosis 5 is TNFRSF1A (TNF Receptor Superfamily Member 1A), and among its related pathways/superpathways are MAPK signaling pathway and Colorectal Cancer Metastasis. Affiliated tissues include monocytes, and related phenotype is adipose tissue.

Description from OMIM: 614810

Related Diseases for Multiple Sclerosis 5

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2 Multiple Sclerosis 3
Multiple Sclerosis 4 Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuronitis 10.0

Symptoms & Phenotypes for Multiple Sclerosis 5

Clinical features from OMIM:

614810

MGI Mouse Phenotypes related to Multiple Sclerosis 5:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 8.62 ARRB1 TNFRSF1A

Drugs & Therapeutics for Multiple Sclerosis 5

Search Clinical Trials , NIH Clinical Center for Multiple Sclerosis 5

Genetic Tests for Multiple Sclerosis 5

Genetic tests related to Multiple Sclerosis 5:

# Genetic test Affiliating Genes
1 Multiple Sclerosis, Susceptibility to, 5 29 TNFRSF1A

Anatomical Context for Multiple Sclerosis 5

MalaCards organs/tissues related to Multiple Sclerosis 5:

41
Monocytes

Publications for Multiple Sclerosis 5

Variations for Multiple Sclerosis 5

ClinVar genetic disease variations for Multiple Sclerosis 5:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TNFRSF1A NM_001065.3(TNFRSF1A): c.625+10A> G single nucleotide variant risk factor rs1800693 GRCh37 Chromosome 12, 6440009: 6440009
2 TNFRSF1A NM_001065.3(TNFRSF1A): c.625+10A> G single nucleotide variant risk factor rs1800693 GRCh38 Chromosome 12, 6330843: 6330843

Expression for Multiple Sclerosis 5

Search GEO for disease gene expression data for Multiple Sclerosis 5.

Pathways for Multiple Sclerosis 5

Pathways related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 ARRB1 TNFRSF1A
2 10.84 ARRB1 TNFRSF1A

GO Terms for Multiple Sclerosis 5

Cellular components related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.62 ARRB1 TNFRSF1A

Biological processes related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 8.96 ARRB1 TNFRSF1A
2 regulation of apoptotic process GO:0042981 8.62 ARRB1 TNFRSF1A

Sources for Multiple Sclerosis 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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