Multiple Sclerosis 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MS5 MCID: MLT124 MIFTS: 23	Multiple Sclerosis 5 (MS5) Categories: Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Expand all tables

Sources

Aliases & Classifications for Multiple Sclerosis 5

MalaCards integrated aliases for Multiple Sclerosis 5:

Name: Multiple Sclerosis 5 ⁵⁷ ⁷²

Multiple Sclerosis, Susceptibility to, 5 ⁵⁷ ²⁹ ¹³ ⁶

Ms5 ⁵⁷ ⁷²

Multiple Sclerosis Susceptibility to, Type 5 ³⁹

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 614810

OMIM Phenotypic Series ⁵⁷ PS126200

MeSH ⁴⁴ D009103

MedGen ⁴¹ C3553728 CN143709

Sources

Summaries for Multiple Sclerosis 5

UniProtKB/Swiss-Prot : ⁷² Multiple sclerosis 5: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

MalaCards based summary : Multiple Sclerosis 5, also known as multiple sclerosis, susceptibility to, 5, is related to multiple sclerosis and multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly. An important gene associated with Multiple Sclerosis 5 is TNFRSF1A (TNF Receptor Superfamily Member 1A). Affiliated tissues include monocytes, bone marrow and spinal cord.

OMIM® : ⁵⁷ Multiple sclerosis-5 (MS5) is a chronic inflammatory disease of the central nervous system characterized by damage to axonal myelin sheaths and axons, commonly resulting in progressive neurologic disability beginning in early adulthood (summary by Xu et al., 2001). For a discussion of genetic heterogeneity of multiple sclerosis (MS), see MS1 (126200). (614810) (Updated 20-May-2021)

Sources

Related Diseases for Multiple Sclerosis 5

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2	Multiple Sclerosis 3
Multiple Sclerosis 4	Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis	Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 5 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	multiple sclerosis	10.1
2	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	9.8
3	urinary tract infection	9.8
4	relapsing-remitting multiple sclerosis	9.8
5	seizure disorder	9.8

Graphical network of the top 20 diseases related to Multiple Sclerosis 5:

Sources

Symptoms & Phenotypes for Multiple Sclerosis 5

Clinical features from OMIM®:

614810 (Updated 20-May-2021)

Sources

Drugs & Therapeutics for Multiple Sclerosis 5

Search Clinical Trials , NIH Clinical Center for Multiple Sclerosis 5

Sources

Genetic Tests for Multiple Sclerosis 5

Genetic tests related to Multiple Sclerosis 5:

#	Genetic test	Affiliating Genes
1	Multiple Sclerosis, Susceptibility to, 5 ²⁹	TNFRSF1A

Sources

Anatomical Context for Multiple Sclerosis 5

MalaCards organs/tissues related to Multiple Sclerosis 5:

⁴⁰

Monocytes, Bone Marrow, Spinal Cord, Brain, Bone

Sources

Publications for Multiple Sclerosis 5

Articles related to Multiple Sclerosis 5:

(show all 33)

#	Title	Authors	PMID	Year
1	TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. ⁶ ⁵⁷	Gregory AP...Fugger L	22801493	2012
2	Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. ⁵⁷	De Jager PL...Oksenberg JR	19525953	2009
3	Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci. ⁵⁷	Xu C...Hillert J	11436128	2001
4	Matching and accepting assistive technology in multiple sclerosis: A focus group study with people with multiple sclerosis, carers and occupational therapists. ⁶¹	Squires LA...Morrison VL	27852887	2019
5	Intrathecal Autologous Bone Marrow-Derived Hematopoietic Stem Cell Therapy in Neurological Diseases. ⁶¹	Zakerinia M...Ramzi M	30863518	2018
6	[Effectiveness and safety of rituximab for children with autoimmune diseases of the nervous system]. ⁶¹	Fu Z...Chen Y	28881516	2017
7	The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence. ⁶¹	Waddell LA...McEWEN SA	25989710	2015
8	Antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and the glycine receptor α1 subunit in patients with isolated optic neuritis. ⁶¹	Martinez-Hernandez E...Dalmau J	25506781	2015
9	Safety profile of dalfampridine extended release in multiple sclerosis: 5-year postmarketing experience in the United States. ⁶¹	Jara M...Rabinowicz AL	26719727	2015
10	Co-existence of neurofibromatosis type 2 and multiple sclerosis: A case report. ⁶¹	Naghshineh H...Minagar A	25876477	2014
11	Pain is associated with prospective memory dysfunction in multiple sclerosis. ⁶¹	Miller AK...Woods SP	25338929	2014
12	An open-label, long-term study examining the safety and tolerability of pregabalin in Japanese patients with central neuropathic pain. ⁶¹	Onouchi K...Yoshiyama T	25114584	2014
13	Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study. ⁶¹	Patti F...COGIMUS Study Group	24137499	2013
14	Treatment outcomes and resource use of patients with neurogenic detrusor overactivity receiving botulinum toxin A (BOTOX) therapy in Germany. ⁶¹	Wefer B...Pannek J	19693509	2010
15	Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. ⁶¹	Kappos L...BENEFIT Study Group	19748319	2009
16	Demonstration of spinal cord and nerve root abnormalities by diffusion neurography. ⁶¹	Tsuchiya K...Nitatori T	18379319	2008
17	Multiple sclerosis: interferon beta for some serious forms. ⁶¹		18092425	2007
18	Leukaemia due to mitoxantrone. ⁶¹		17724842	2007
19	IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. ⁶¹	Goodin DS	17000997	2006
20	IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. ⁶¹	Kinkel RP...CHAMPIONS Study Group	16436649	2006
21	Brain cytokines and disease. ⁶¹	Plata-Salaman CR	26984574	2002
22	Diagnostic potential of mitochondrial DNA assessment in patients with optic neuropathy. ⁶¹	Feng X...Ohba N	11776061	2000
23	Non-compressive myelopathy: clinical and radiological study. ⁶¹	Prabhakar S...Das CP	10625902	1999
24	A multi-centre longitudinal study comparing the sensitivity of monthly MRI after standard and triple dose gadolinium-DTPA for monitoring disease activity in multiple sclerosis. Implications for phase II clinical trials. ⁶¹	Filippi M...Comi G	9798753	1998
25	MRI demonstration of Wallerian degeneration in various intracranial lesions and its clinical implications. ⁶¹	Sawlani V...Kohli A	9077505	1997
26	A controlled study of reliability and validity of MRI findings in neuro-Behçet's disease. ⁶¹	Coban O...Yazici H	8738085	1996
27	[The clinical diagnostic value of studies using magnetic stimulation]. ⁶¹	Hageman G...Tel-Hampsink J	8255340	1993
28	Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction. ⁶¹	Buckle GJ...Asher DM	1335225	1992
29	Serum antibodies to HTLV-I in Thai patients with chronic progressive myelopathy, multiple sclerosis, myopathy and in HIV-seropositive intravenous drug abusers. ⁶¹	Hemachudha T...Phanthumchinda K	2751768	1989
30	[Anti-neurofilament antibodies in slow infections of the nervous system]. ⁶¹	Zavalishin IA...Niiazbekova AS	3376639	1988
31	Dysfunction of the detrusor and urethra in multiple sclerosis: the role of drug therapy. ⁶¹	Awad SA...Kiruluta HG	6123379	1982
32	Use of the Pulfrich pendulum for detecting abnormal delay in the visual pathway in multiple sclerosis. ⁶¹	Rushton D	1148820	1975
33	[Multiple sclerosis. 5. Cytologic changes in the cerebrospinal fluid]. ⁶¹	Sornas R	5452189	1970

Sources

Genes for Multiple Sclerosis 5

Genes related to Multiple Sclerosis 5 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	682.42	Molecular basis known ⁵⁷ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ Risk factor ⁶ GeneCards inferred via : Disorders (show sections)	22801493

Sources

Variations for Multiple Sclerosis 5

ClinVar genetic disease variations for Multiple Sclerosis 5:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TNFRSF1A	NM_001065.4(TNFRSF1A):c.625+10A>G	SNV	risk factor	37038	rs1800693	GRCh37: 12:6440009-6440009 GRCh38: 12:6330843-6330843
2	TNFRSF1A	NM_001065.4(TNFRSF1A):c.362G>A (p.Arg121Gln)	SNV	Uncertain significance	217017	rs4149584	GRCh37: 12:6442643-6442643 GRCh38: 12:6333477-6333477

Sources

Expression for Multiple Sclerosis 5

Search GEO for disease gene expression data for Multiple Sclerosis 5.

Sources

Pathways for Multiple Sclerosis 5

Sources

GO Terms for Multiple Sclerosis 5

Sources

Sources for Multiple Sclerosis 5

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Multiple Sclerosis 5 (MS5)

Aliases & Classifications for Multiple Sclerosis 5

MalaCards integrated aliases for Multiple Sclerosis 5:

Classifications:

External Ids:

Summaries for Multiple Sclerosis 5

Related Diseases for Multiple Sclerosis 5

Diseases in the Multiple Sclerosis family:

Diseases related to Multiple Sclerosis 5 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Multiple Sclerosis 5:

Symptoms & Phenotypes for Multiple Sclerosis 5

Clinical features from OMIM®:

Drugs & Therapeutics for Multiple Sclerosis 5

Genetic Tests for Multiple Sclerosis 5

Genetic tests related to Multiple Sclerosis 5:

Anatomical Context for Multiple Sclerosis 5

MalaCards organs/tissues related to Multiple Sclerosis 5:

Publications for Multiple Sclerosis 5

Articles related to Multiple Sclerosis 5:

Genes for Multiple Sclerosis 5

Genes related to Multiple Sclerosis 5 (1 elite genes):

Variations for Multiple Sclerosis 5

ClinVar genetic disease variations for Multiple Sclerosis 5:

Expression for Multiple Sclerosis 5

Pathways for Multiple Sclerosis 5

GO Terms for Multiple Sclerosis 5

Sources for Multiple Sclerosis 5