Multiple Sclerosis 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Multiple Sclerosis 5

MalaCards integrated aliases for Multiple Sclerosis 5:

Name: Multiple Sclerosis 5 ⁵⁷ ⁷⁵

Multiple Sclerosis, Susceptibility to, 5 ⁵⁷ ²⁹ ¹³ ⁶

Ms5 ⁵⁷ ⁷⁵

Multiple Sclerosis Susceptibility to, Type 5 ⁴⁰

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 614810

MedGen ⁴² C3553728 CN143709

MeSH ⁴⁴ D009103

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Summaries for Multiple Sclerosis 5

UniProtKB/Swiss-Prot : ⁷⁵ Multiple sclerosis 5: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.

MalaCards based summary : Multiple Sclerosis 5, also known as multiple sclerosis, susceptibility to, 5, is related to neuronitis. An important gene associated with Multiple Sclerosis 5 is TNFRSF1A (TNF Receptor Superfamily Member 1A), and among its related pathways/superpathways are MAPK signaling pathway and Colorectal Cancer Metastasis. Affiliated tissues include monocytes, and related phenotype is adipose tissue.

Description from OMIM: 614810

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Related Diseases for Multiple Sclerosis 5

Diseases in the Multiple Sclerosis family:

Multiple Sclerosis 2	Multiple Sclerosis 3
Multiple Sclerosis 4	Multiple Sclerosis 5
Secondary Progressive Multiple Sclerosis	Primary Progressive Multiple Sclerosis

Diseases related to Multiple Sclerosis 5 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	neuronitis	10.0

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Symptoms & Phenotypes for Multiple Sclerosis 5

Clinical features from OMIM:

614810

MGI Mouse Phenotypes related to Multiple Sclerosis 5:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue	MP:0005375	8.62	ARRB1 TNFRSF1A

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Drugs & Therapeutics for Multiple Sclerosis 5

Search Clinical Trials , NIH Clinical Center for Multiple Sclerosis 5

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Genetic Tests for Multiple Sclerosis 5

Genetic tests related to Multiple Sclerosis 5:

#	Genetic test	Affiliating Genes
1	Multiple Sclerosis, Susceptibility to, 5 ²⁹	TNFRSF1A

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Anatomical Context for Multiple Sclerosis 5

MalaCards organs/tissues related to Multiple Sclerosis 5:

⁴¹

Monocytes

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Publications for Multiple Sclerosis 5

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Genes for Multiple Sclerosis 5

Genes related to Multiple Sclerosis 5 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	692.97	Molecular basis known ⁵⁷ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ Risk factor ⁶ GeneCards inferred via : Disorders (show sections)	22801493
2	ARRB1	Arrestin Beta 1	Protein Coding	6.6	GeneCards inferred via : Publications (show sections)

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Variations for Multiple Sclerosis 5

ClinVar genetic disease variations for Multiple Sclerosis 5:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	TNFRSF1A	NM_001065.3(TNFRSF1A): c.625+10A> G	single nucleotide variant	risk factor	rs1800693	GRCh37	Chromosome 12, 6440009: 6440009
2	TNFRSF1A	NM_001065.3(TNFRSF1A): c.625+10A> G	single nucleotide variant	risk factor	rs1800693	GRCh38	Chromosome 12, 6330843: 6330843

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Expression for Multiple Sclerosis 5

Search GEO for disease gene expression data for Multiple Sclerosis 5.

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Pathways for Multiple Sclerosis 5

Pathways related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MAPK signaling pathway ¹ ³⁷	11.62	ARRB1 TNFRSF1A
2	Colorectal Cancer Metastasis ⁶⁴	10.84	ARRB1 TNFRSF1A

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GO Terms for Multiple Sclerosis 5

Cellular components related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:0000139	8.62	ARRB1 TNFRSF1A

Biological processes related to Multiple Sclerosis 5 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	8.96	ARRB1 TNFRSF1A
2	regulation of apoptotic process	GO:0042981	8.62	ARRB1 TNFRSF1A

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Sources for Multiple Sclerosis 5

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia