MSA-C
MCID: MLT105
MIFTS: 25

Multiple System Atrophy, Cerebellar Type (MSA-C)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Multiple System Atrophy, Cerebellar Type

MalaCards integrated aliases for Multiple System Atrophy, Cerebellar Type:

Name: Multiple System Atrophy, Cerebellar Type 58
Sporadic Olivopontocerebellar Atrophy Type 1 58
Msa, Cerebellar Type 58
Sporadic Opca Type 1 58
Msa-C 58

Characteristics:

Orphanet epidemiological data:

58
multiple system atrophy, cerebellar type
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Multiple System Atrophy, Cerebellar Type

MalaCards based summary : Multiple System Atrophy, Cerebellar Type, also known as sporadic olivopontocerebellar atrophy type 1, is related to multiple system atrophy 1 and ataxia and polyneuropathy, adult-onset. An important gene associated with Multiple System Atrophy, Cerebellar Type is COQ2 (Coenzyme Q2, Polyprenyltransferase). Affiliated tissues include eye, brain and monocytes, and related phenotypes are abnormal pyramidal sign and depressivity

Related Diseases for Multiple System Atrophy, Cerebellar Type

Diseases related to Multiple System Atrophy, Cerebellar Type via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 multiple system atrophy 1 10.7
2 ataxia and polyneuropathy, adult-onset 10.5
3 autosomal dominant cerebellar ataxia 10.4
4 machado-joseph disease 10.3
5 parkinsonism 10.3
6 multiple system atrophy, parkinsonian type 10.3
7 rem sleep behavior disorder 10.2
8 pure autonomic failure 10.2
9 mild cognitive impairment 10.1
10 dementia 10.1
11 impotence 10.1
12 sleep disorder 10.1
13 primary orthostatic hypotension 10.1
14 autonomic dysfunction 10.1
15 dysautonomia 10.1
16 dysphagia 10.1
17 spinocerebellar degeneration 10.1
18 tremor 10.1
19 cerebellar degeneration 10.0
20 spinocerebellar ataxia 2 9.9
21 spinocerebellar ataxia 17 9.9
22 spastic paraplegia 7, autosomal recessive 9.9
23 aspiration pneumonia 9.9
24 dystonia 9.9
25 myoclonus 9.9
26 sporadic adult-onset ataxia of unknown etiology 9.9

Graphical network of the top 20 diseases related to Multiple System Atrophy, Cerebellar Type:



Diseases related to Multiple System Atrophy, Cerebellar Type

Symptoms & Phenotypes for Multiple System Atrophy, Cerebellar Type

Human phenotypes related to Multiple System Atrophy, Cerebellar Type:

58 31 (show all 35)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal pyramidal sign 58 31 frequent (33%) Frequent (79-30%) HP:0007256
2 depressivity 58 31 frequent (33%) Frequent (79-30%) HP:0000716
3 dysarthria 58 31 frequent (33%) Frequent (79-30%) HP:0001260
4 dysphonia 58 31 frequent (33%) Frequent (79-30%) HP:0001618
5 constipation 58 31 frequent (33%) Frequent (79-30%) HP:0002019
6 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
7 gait ataxia 58 31 frequent (33%) Frequent (79-30%) HP:0002066
8 broad-based gait 58 31 frequent (33%) Frequent (79-30%) HP:0002136
9 stridor 58 31 frequent (33%) Frequent (79-30%) HP:0010307
10 axial dystonia 58 31 frequent (33%) Frequent (79-30%) HP:0002530
11 frequent falls 58 31 frequent (33%) Frequent (79-30%) HP:0002359
12 orthostatic hypotension due to autonomic dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0004926
13 raynaud phenomenon 58 31 frequent (33%) Frequent (79-30%) HP:0030880
14 progressive cerebellar ataxia 58 31 frequent (33%) Frequent (79-30%) HP:0002073
15 postural instability 58 31 frequent (33%) Frequent (79-30%) HP:0002172
16 abnormal rapid eye movement sleep 58 31 frequent (33%) Frequent (79-30%) HP:0002494
17 limb ataxia 58 31 frequent (33%) Frequent (79-30%) HP:0002070
18 orofacial dyskinesia 58 31 frequent (33%) Frequent (79-30%) HP:0002310
19 central sleep apnea 58 31 frequent (33%) Frequent (79-30%) HP:0010536
20 postural tremor 58 31 frequent (33%) Frequent (79-30%) HP:0002174
21 autonomic erectile dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0008652
22 autonomic bladder dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0005341
23 abnormal brain fdg positron emission tomography 58 31 frequent (33%) Frequent (79-30%) HP:0012658
24 gaze-evoked nystagmus 58 31 frequent (33%) Frequent (79-30%) HP:0000640
25 downbeat nystagmus 58 31 frequent (33%) Frequent (79-30%) HP:0010545
26 orthostatic syncope 58 31 frequent (33%) Frequent (79-30%) HP:0012670
27 female anorgasmia 58 31 frequent (33%) Frequent (79-30%) HP:0030015
28 neuromuscular dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0002068
29 rigidity 58 31 occasional (7.5%) Occasional (29-5%) HP:0002063
30 apathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000741
31 parkinsonism 58 31 occasional (7.5%) Occasional (29-5%) HP:0001300
32 bradykinesia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002067
33 resting tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0002322
34 camptocormia 58 31 occasional (7.5%) Occasional (29-5%) HP:0100595
35 dysautonomia 58 Frequent (79-30%)

Drugs & Therapeutics for Multiple System Atrophy, Cerebellar Type

Search Clinical Trials , NIH Clinical Center for Multiple System Atrophy, Cerebellar Type

Genetic Tests for Multiple System Atrophy, Cerebellar Type

Anatomical Context for Multiple System Atrophy, Cerebellar Type

MalaCards organs/tissues related to Multiple System Atrophy, Cerebellar Type:

40
Eye, Brain, Monocytes, Pons

Publications for Multiple System Atrophy, Cerebellar Type

Articles related to Multiple System Atrophy, Cerebellar Type:

(show all 42)
# Title Authors PMID Year
1
3-Hz Postural Tremor in MSA-C and SCA: Revisiting an Old but Underestimated Cerebellar Sign by Posturography. 61
33164129 2021
2
A Life-threatening Complication of Multiple System Atrophy. 61
33678286 2021
3
Swallowing Outcomes Following Voice Therapy in Multiple System Atrophy with Dysphagia: Comparison of Treatment Efficacy with Parkinson's Disease. 61
33666739 2021
4
Amelioration of motor and nonmotor symptoms in cortical cerebellar atrophy and multiple system atrophy-cerebellar type by inpatient rehabilitation: a retrospective study. 61
33481455 2021
5
Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type. 61
32977251 2020
6
Cerebellar Atrophy in Multiple System Atrophy (Cerebellar Type) and Its Implication for Network Connectivity. 61
32472475 2020
7
Differential value of external anal- and urethral-sphincter electromyography in multiple system atrophy cerebellar type and spinocerebellar ataxias. 61
33099340 2020
8
Multiple System Atrophy - Cerebellar Type: Clinical Picture and Treatment of an Often-Overlooked Disorder. 61
33173654 2020
9
Vertical pons hyperintensity and hot cross bun sign in cerebellar-type multiple system atrophy and spinocerebellar ataxia type 3. 61
32340608 2020
10
Diffusion Tensor Magnetic Resonance Imaging for Differentiating Multiple System Atrophy Cerebellar Type and Spinocerebellar Ataxia Type 3. 61
31817016 2019
11
Screening for Niemann-Pick type C disease in neurodegenerative diseases. 61
31221578 2019
12
Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features. 61
31152261 2019
13
Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar type. 61
30745212 2019
14
What Is Behind Cerebellar Vertigo and Dizziness? 61
30552638 2019
15
An autopsy case of progressive multifocal leukoencephalopathy after rituximab therapy for malignant lymphoma. 61
30511425 2019
16
Spatial Patterns of Decreased Cerebral Blood Flow and Functional Connectivity in Multiple System Atrophy (Cerebellar-Type): A Combined Arterial Spin Labeling Perfusion and Resting State Functional Magnetic Resonance Imaging Study. 61
31417345 2019
17
Is 1H-MR spectroscopy useful as a diagnostic aid in MSA-C? 61
31321064 2019
18
Clinics in diagnostic imaging (191). Multiple system atrophy-cerebellar type (MSA-C). 61
30386855 2018
19
3-Hz postural tremor in multiple system atrophy cerebellar type (MSA-C)-a static posturography study. 61
29027029 2018
20
Neuroimaging Applications in Chronic Ataxias. 61
30473193 2018
21
Altered Functional Connectivity of Cerebello-Cortical Circuit in Multiple System Atrophy (Cerebellar-Type). 61
30662394 2018
22
Clinical and genetic characteristics of sporadic adult-onset degenerative ataxia. 61
28794257 2017
23
Early strong intrathecal inflammation in cerebellar type multiple system atrophy by cerebrospinal fluid cytokine/chemokine profiles: a case control study. 61
28438224 2017
24
Treatment of Spinocerebellar Ataxia With Mesenchymal Stem Cells: A Phase I/IIa Clinical Study. 61
28195034 2017
25
Additional Value of Early-Phase 18F-FP-CIT PET Image for Differential Diagnosis of Atypical Parkinsonism. 61
27922865 2017
26
The Diagnosis and Natural History of Multiple System Atrophy, Cerebellar Type. 61
26467153 2016
27
Significance of combined use of MRI and perfusion SPECT for evaluation of multiple system atrophy, cerebellar type. 61
26253930 2016
28
Familial Adult-Onset Alexander Disease with a Novel GFAP Mutation. 61
30363563 2016
29
"Cerebellar peduncle quarter notes" formed by the superior and middle cerebellar peduncles: comparison with a diffusion tensor study of spinocerebellar degeneration. 61
25749832 2015
30
Cerebrospinal Fluid Biomarkers in Spinocerebellar Ataxia: A Pilot Study. 61
26265793 2015
31
Dynamic Cerebrospinal Fluid Flow on MRI in Cortical Cerebellar Atrophy and Multiple System Atrophy-cerebellar Type. 61
26179524 2015
32
Differential Progression of Dysphagia in Heredity and Sporadic Ataxias Involving Multiple Systems. 61
26618669 2015
33
Non-ergot dopamine agonist rotigotine as a promising therapeutic tool in atypical parkinsonism syndromes: a 24 months pilot observational open-label study. 61
24915072 2014
34
Rotigotine is safe and efficacious in Atypical Parkinsonism Syndromes induced by both α-synucleinopathy and tauopathy. 61
24940065 2014
35
The merit of proton magnetic resonance spectroscopy in the longitudinal assessment of spinocerebellar ataxias and multiple system atrophy-cerebellar type. 61
26331041 2014
36
Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging. 61
24895507 2013
37
A case of multiple system atrophy-cerebellar type preceded by dementia. 61
24868414 2012
38
Differences between spinocerebellar ataxias and multiple system atrophy-cerebellar type on proton magnetic resonance spectroscopy. 61
23118909 2012
39
Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells. 61
21545234 2011
40
Difference in the effects of tandospirone on ataxia in various types of spinocerebellar degeneration: an open-label study. 61
20809107 2010
41
Diffusivity and diffusion anisotropy of cerebellar peduncles in cases of spinocerebellar degenerative disease. 61
17583535 2007
42
Pathological laughter and crying in patients with multiple system atrophy-cerebellar type. 61
17290465 2007

Variations for Multiple System Atrophy, Cerebellar Type

Expression for Multiple System Atrophy, Cerebellar Type

Search GEO for disease gene expression data for Multiple System Atrophy, Cerebellar Type.

Pathways for Multiple System Atrophy, Cerebellar Type

GO Terms for Multiple System Atrophy, Cerebellar Type

Sources for Multiple System Atrophy, Cerebellar Type

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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