MCID: MLT116
MIFTS: 21

Multiple System Atrophy, Parkinsonian Type

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Multiple System Atrophy, Parkinsonian Type

MalaCards integrated aliases for Multiple System Atrophy, Parkinsonian Type:

Name: Multiple System Atrophy, Parkinsonian Type 59
Msa, Parkinsonian Type 59
Msa-P 59

Characteristics:

Orphanet epidemiological data:

59
multiple system atrophy, parkinsonian type
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 59  
Rare neurological diseases


Summaries for Multiple System Atrophy, Parkinsonian Type

MalaCards based summary : Multiple System Atrophy, Parkinsonian Type, also known as msa, parkinsonian type, is related to multiple system atrophy 1 and cerebritis. An important gene associated with Multiple System Atrophy, Parkinsonian Type is COQ2 (Coenzyme Q2, Polyprenyltransferase). Affiliated tissues include brain and eye, and related phenotypes are depressivity and dysarthria

Related Diseases for Multiple System Atrophy, Parkinsonian Type

Diseases related to Multiple System Atrophy, Parkinsonian Type via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 multiple system atrophy 1 10.1
2 cerebritis 9.9

Symptoms & Phenotypes for Multiple System Atrophy, Parkinsonian Type

Human phenotypes related to Multiple System Atrophy, Parkinsonian Type:

59 32 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 59 32 frequent (33%) Frequent (79-30%) HP:0000716
2 dysarthria 59 32 occasional (7.5%) Occasional (29-5%) HP:0001260
3 constipation 59 32 frequent (33%) Frequent (79-30%) HP:0002019
4 abnormal pyramidal signs 59 32 frequent (33%) Frequent (79-30%) HP:0007256
5 anxiety 59 32 frequent (33%) Frequent (79-30%) HP:0000739
6 gait ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002066
7 rigidity 59 32 frequent (33%) Frequent (79-30%) HP:0002063
8 progressive cerebellar ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002073
9 postural tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0002174
10 bradykinesia 59 32 frequent (33%) Frequent (79-30%) HP:0002067
11 frequent falls 59 32 frequent (33%) Frequent (79-30%) HP:0002359
12 stridor 59 32 frequent (33%) Frequent (79-30%) HP:0010307
13 orthostatic hypotension due to autonomic dysfunction 59 32 frequent (33%) Frequent (79-30%) HP:0004926
14 parkinsonism 59 32 frequent (33%) Frequent (79-30%) HP:0001300
15 apathy 59 32 frequent (33%) Frequent (79-30%) HP:0000741
16 postural instability 59 32 frequent (33%) Frequent (79-30%) HP:0002172
17 abnormal brain fdg positron emission tomography 59 32 frequent (33%) Frequent (79-30%) HP:0012658
18 raynaud phenomenon 59 32 frequent (33%) Frequent (79-30%) HP:0030880
19 orofacial dyskinesia 59 32 frequent (33%) Frequent (79-30%) HP:0002310
20 gaze-evoked nystagmus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000640
21 resting tremor 59 32 frequent (33%) Frequent (79-30%) HP:0002322
22 central sleep apnea 59 32 frequent (33%) Frequent (79-30%) HP:0010536
23 abnormal rapid eye movement sleep 59 32 frequent (33%) Frequent (79-30%) HP:0002494
24 axial dystonia 59 32 frequent (33%) Frequent (79-30%) HP:0002530
25 autonomic bladder dysfunction 59 32 frequent (33%) Frequent (79-30%) HP:0005341
26 autonomic erectile dysfunction 59 32 frequent (33%) Frequent (79-30%) HP:0008652
27 orthostatic syncope 59 32 frequent (33%) Frequent (79-30%) HP:0012670
28 female anorgasmia 59 32 frequent (33%) Frequent (79-30%) HP:0030015
29 camptocormia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100595
30 dysautonomia 59 Frequent (79-30%)

Drugs & Therapeutics for Multiple System Atrophy, Parkinsonian Type

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Multiple System Atrophy, Parkinsonian Type

Genetic Tests for Multiple System Atrophy, Parkinsonian Type

Anatomical Context for Multiple System Atrophy, Parkinsonian Type

MalaCards organs/tissues related to Multiple System Atrophy, Parkinsonian Type:

41
Brain, Eye

Publications for Multiple System Atrophy, Parkinsonian Type

Articles related to Multiple System Atrophy, Parkinsonian Type:

# Title Authors Year
1
Altered Functional and Causal Connectivity of Cerebello-Cortical Circuits between Multiple System Atrophy (Parkinsonian Type) and Parkinson's Disease. ( 28848423 )
2017
2
Comparison of cerebral glucose metabolism between multiple system atrophy Parkinsonian type and Parkinson's disease. ( 18544255 )
2008

Variations for Multiple System Atrophy, Parkinsonian Type

Expression for Multiple System Atrophy, Parkinsonian Type

Search GEO for disease gene expression data for Multiple System Atrophy, Parkinsonian Type.

Pathways for Multiple System Atrophy, Parkinsonian Type

GO Terms for Multiple System Atrophy, Parkinsonian Type

Sources for Multiple System Atrophy, Parkinsonian Type

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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