MIC
MCID: MLT180
MIFTS: 33

Multisystem Inflammatory Syndrome in Children (MIC)

Categories: Blood diseases, Infectious diseases

Aliases & Classifications for Multisystem Inflammatory Syndrome in Children

MalaCards integrated aliases for Multisystem Inflammatory Syndrome in Children:

Name: Multisystem Inflammatory Syndrome in Children 12 15
Multisystem Inflammatory Disorder in Children and Adolescents 12
Paediatric Inflammatory Multisystemic Syndrome 12
Mis-C 12
Mic 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0080711

Summaries for Multisystem Inflammatory Syndrome in Children

Disease Ontology : 12 A Coronavirus infectious disease that is characterized by a patient aged less than 21 years with fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization, with multisystem organ involvement (cardiovascular, dermatologic, gastrointestinal, hematologic, neurologic, renal, or respiratory) who tested positive for SARS-CoV-2 or had exposure to COVID-19.

MalaCards based summary : Multisystem Inflammatory Syndrome in Children, also known as multisystem inflammatory disorder in children and adolescents, is related to microcephaly-capillary malformation syndrome and severe acute respiratory syndrome. An important gene associated with Multisystem Inflammatory Syndrome in Children is MIR99A (MicroRNA 99a). The drugs Prednisolone acetate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone marrow.

Wikipedia : 73 Multisystem inflammatory syndrome in children (MIS-C), or paediatric inflammatory multisystem syndrome... more...

Related Diseases for Multisystem Inflammatory Syndrome in Children

Diseases related to Multisystem Inflammatory Syndrome in Children via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 microcephaly-capillary malformation syndrome 11.4
2 severe acute respiratory syndrome 11.0
3 methyl isocyanate allergic asthma 11.0
4 kawasaki disease 10.9
5 covid-19 10.8
6 exanthem 10.7
7 conjunctivitis 10.6
8 toxic shock syndrome 10.6
9 myocarditis 10.5
10 macrophage activation syndrome 10.5
11 coronary artery aneurysm 10.5
12 cardiogenic shock 10.4
13 haemophilus influenzae 10.4
14 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
15 congestive heart failure 10.4
16 heart disease 10.4
17 thrombocytopenia 10.4
18 appendicitis 10.4
19 mycobacterium tuberculosis 1 10.4
20 retinal cancer 10.3 PAGR1 MIR486-1 MIR365A
21 nasopharyngeal disease 10.3 MIR99A MIR486-1 MIR365A
22 upper respiratory tract disease 10.3 MIR99A MIR486-1 MIR365A
23 disease by infectious agent 10.3
24 lymphopenia 10.3
25 vasculitis 10.3
26 47,xyy 10.3
27 endocarditis 10.3
28 candida glabrata 10.3
29 mouth disease 10.2 MIR99A MIR486-1 MIR221
30 pancreas disease 10.2 MIR99A MIR486-1 MIR365A MIR221
31 bladder disease 10.2 MIR99A MIR486-1 MIR100
32 urinary system disease 10.2 MIR99A MIR486-1 MIR221 MIR100
33 female reproductive system disease 10.2 MIR99A MIR486-1 MIR221 MIR100
34 mulchandani-bhoj-conlin syndrome 10.2
35 candidiasis 10.2
36 reproductive system disease 10.2 MIR99A MIR486-1 MIR221 MIR100
37 respiratory system cancer 10.2 MIR99A MIR486-1 MIR365A MIR221
38 gastrointestinal system cancer 10.2 MIR99A MIR486-1 MIR221 MIR100
39 gastrointestinal system disease 10.2 MIR99A MIR486-1 MIR221 MIR100
40 oral squamous cell carcinoma 10.2 MIR99A MIR365A MIR221 MIR100
41 endocrine system disease 10.2 MIR99A MIR486-1 MIR221 MIR191
42 urinary tract infection 10.2
43 acquired metabolic disease 10.2 MIR486-1 MIR221 MIR191
44 rheumatic fever-related antigen 10.2
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
46 storm syndrome 10.2
47 hemophagocytic lymphohistiocytosis 10.2
48 epidemic typhus 10.2
49 endemic typhus 10.2
50 mucositis 10.2

Graphical network of the top 20 diseases related to Multisystem Inflammatory Syndrome in Children:



Diseases related to Multisystem Inflammatory Syndrome in Children

Symptoms & Phenotypes for Multisystem Inflammatory Syndrome in Children

Drugs & Therapeutics for Multisystem Inflammatory Syndrome in Children

Drugs for Multisystem Inflammatory Syndrome in Children (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Gastrointestinal Agents Phase 3
8 Antiemetics Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Immunoglobulins Phase 3
11 Neuroprotective Agents Phase 3
12 Immunoglobulins, Intravenous Phase 3
13 Antibodies Phase 3
14 Methylprednisolone Acetate Phase 3
15 Protective Agents Phase 3
16 Hormone Antagonists Phase 3
17 glucocorticoids Phase 3
18 Immunologic Factors Phase 3
19 Hormones Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21
Altretamine Approved Phase 1 645-05-6 2123
22 Plasma-lyte 148 Phase 1
23
Promethazine Approved, Investigational 60-87-7 4927
24
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
25
Diphenhydramine Approved, Investigational 58-73-1, 147-24-0 3100
26
Hydrocortisone Approved, Vet_approved 50-23-7 5754
27
Hydrocortisone acetate Approved, Vet_approved 50-03-3
28
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
29 Anesthetics
30 Hypnotics and Sedatives
31 Neurotransmitter Agents
32 Histamine Antagonists
33 Dermatologic Agents
34
Histamine Phosphate 51-74-1 65513
35 Anesthetics, Local
36 Histamine H1 Antagonists
37 Anti-Allergic Agents
38 Hydrocortisone hemisuccinate
39 Hydrocortisone 17-butyrate 21-propionate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomised Evaluation of COVID-19 Therapy (RECOVERY) in Children With PIMS-TS in Switzerland (SWISSPED-RECOVERY) Not yet recruiting NCT04826588 Phase 3 Methylprednisolone sodium succinate
2 A Phase I Pilot Study of the Safety of Infusions of Allogeneic Human Cord Tissue Mesenchymal Stromal Cells in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) Recruiting NCT04549285 Phase 1
3 Characterization of Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Relationship to Kawasaki Disease Recruiting NCT04538495
4 An Observational Cohort Study to Determine Late Outcomes and Immunological Responses After Infection With SARS-CoV-2 in Children With and Without Multisystem Inflammatory Syndrome (MIS-C) Recruiting NCT04588363
5 Intermediate-size Expanded Access of Remestemcel-L, Human Mesenchymal Stromal Cells, for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19) Available NCT04456439 Hydrocortisone;Diphenhydramine
6 Investigating Cytokine Storm Biomarkers in Children Presenting to Acute Paediatric Services (Non-intensive Care) With Paediatric Inflammatory Multisystem Syndrome During the Covid-19 Pandemic. An Observation Study Not yet recruiting NCT04761913
7 A Prospective Study of COVID-19 and Related Outcomes in School Aged Children (ABC Health Outcomes in Children) Not yet recruiting NCT04757831
8 Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up Not yet recruiting NCT04830852

Search NIH Clinical Center for Multisystem Inflammatory Syndrome in Children

Genetic Tests for Multisystem Inflammatory Syndrome in Children

Anatomical Context for Multisystem Inflammatory Syndrome in Children

MalaCards organs/tissues related to Multisystem Inflammatory Syndrome in Children:

40
Kidney, Liver, Bone Marrow, Skin, T Cells

Publications for Multisystem Inflammatory Syndrome in Children

Articles related to Multisystem Inflammatory Syndrome in Children:

(show top 50) (show all 339)
# Title Authors PMID Year
1
Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2. 61
33332607 2021
2
Shock and Myocardial Injury in Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection: What We Know. Case Series and Review of the Literature. 61
33148089 2021
3
Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance. 61
33676141 2021
4
Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France. 61
33394320 2021
5
Murine Typhus in 5 Children Hospitalized for Multisystem Inflammatory Syndrome in Children. 61
33431429 2021
6
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2. 61
33277976 2021
7
Surveillance of COVID-19-Associated Multisystem Inflammatory Syndrome in Children, South Korea. 61
33539720 2021
8
Multisystem Inflammatory Syndrome in Children Mimicking Surgical Pathologies: What Surgeons Need to Know about MIS-C. 61
33074884 2021
9
Mistaken MIS-C: A Case Series of Bacterial Enteritis Mimicking MIS-C. 61
33710982 2021
10
Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA: a retrospective surveillance study. 61
33711293 2021
11
HLA class I-associated expansion of TRBV11-2 T cells in Multisystem Inflammatory Syndrome in Children. 61
33705359 2021
12
Letter by Navarro Castellanos and Dahdah Regarding Article, "Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic". 61
33683948 2021
13
Letter by Loomba et al Regarding Article, "Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic". 61
33683950 2021
14
Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up. 61
33003176 2021
15
Presumptive Neonatal Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019. 61
33757142 2021
16
ACUTE EPIDIDYMITIS ASSOCIATED WITH MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN. 61
33704847 2021
17
Clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C) below age 1. 61
33763799 2021
18
Association Between Treatments and Short-Term Biochemical Improvements and Clinical Outcomes in Postsevere Acute Respiratory Syndrome Coronavirus-2 Inflammatory Syndrome. 61
33767074 2021
19
ACUTE APPENDICITIS MIMICKING MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN: CASE REPORT AND REVIEW OF THE LITERATURE. 61
33586818 2021
20
Multisystem inflammatory syndrome in children (MIS-C) and retropharyngeal edema: A case series. 61
33752089 2021
21
Factors Associated With Severe SARS-CoV-2 Infection. 61
33323493 2021
22
Letter by Ren et al Regarding Article, "Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic". 61
33683944 2021
23
Letter by Cardenas Suri and Jimomila Bening Regarding Article, "Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic". 61
33683946 2021
24
Distinguishing Features of Patients Evaluated for Multisystem Inflammatory Syndrome in Children. 61
33651762 2021
25
Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth. 61
33197493 2021
26
Screening of COVID-19 in outpatient children with cancer or solid organ transplantation: preliminary report. 61
33768332 2021
27
An analysis of chronic kidney disease as a prognostic factor in pediatric cases of COVID-19. 61
33704348 2021
28
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. 61
33653907 2021
29
A response to "Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children''. 61
33677002 2021
30
The inflammatory markers of multisystem inflammatory syndrome in children (MIS-C) and adolescents associated with COVID-19: A meta-analysis. 61
33739452 2021
31
Epidemiology, characteristics and outcome of children hospitalized with COVID-19 in Oman: A multicenter cohort study. 61
33476759 2021
32
Cardiac abnormalities due to multisystem inflammatory syndrome temporally associated with Covid-19 among children: A systematic review and meta-analysis. 61
33778151 2021
33
Correction to: Multisystem inflammatory syndrome in children during the COVID-19 pandemic in Turkey: first report from the Eastern Mediterranean. 61
33738688 2021
34
Different hair loss patterns in two pediatric patients with COVID-19-associated multisystem inflammatory syndrome in children. 61
33506994 2021
35
COVID-19 in childhood: Transmission, clinical presentation, complications and risk factors. 61
33721405 2021
36
The emergence of a new cytokine storm during the COVID-19 pandemic: Multisystem inflammatory syndrome in children. 61
33400372 2021
37
Acute covid-19 and multisystem inflammatory syndrome in children. 61
33648933 2021
38
Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children. 61
33523115 2021
39
Coronavirus disease 2019 in the pediatric emergency department: unique considerations in preparation and response. 61
33782243 2021
40
Humoral signatures of protective and pathological SARS-CoV-2 infection in children. 61
33589825 2021
41
Short-Term sequelae of Multisystem Inflammatory Syndrome in Children Assessed by CMR. 61
33744139 2021
42
Multisystem Inflammatory Syndrome in Children, Chile, May-August 2020. 61
33760725 2021
43
Arteritis and Large Vessel Occlusive Strokes in Children After COVID-19 Infection. 61
33277353 2021
44
Cutaneous Findings in SARS-CoV-2-Associated Multisystem Inflammatory Disease in Children. 61
33778091 2021
45
Clinical and radiological findings for the new multisystem inflammatory syndrome in children associated with COVID-19. 61
33785227 2021
46
Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children: a review of 47 pediatric patients. 61
33632409 2021
47
Abnormal Nailfold Capillaroscopy in a Patient With Multisystem Inflammatory Syndrome in Children. 61
33565816 2021
48
Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France. 61
33190340 2021
49
Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view. 61
32946801 2021
50
Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2. 61
33479801 2021

Variations for Multisystem Inflammatory Syndrome in Children

Expression for Multisystem Inflammatory Syndrome in Children

Search GEO for disease gene expression data for Multisystem Inflammatory Syndrome in Children.

Pathways for Multisystem Inflammatory Syndrome in Children

GO Terms for Multisystem Inflammatory Syndrome in Children

Cellular components related to Multisystem Inflammatory Syndrome in Children according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.02 MIR99A MIR365A MIR221 MIR191 MIR100
2 signal recognition particle, endoplasmic reticulum targeting GO:0005786 8.96 RN7SL3 RN7SL2

Biological processes related to Multisystem Inflammatory Syndrome in Children according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA mediated inhibition of translation GO:0035278 9.43 MIR365A MIR221 MIR100
2 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition GO:0006617 9.16 RN7SL3 RN7SL2
3 gene silencing by miRNA GO:0035195 9.1 MIR99A MIR486-1 MIR365A MIR221 MIR191 MIR100
4 negative regulation of vascular smooth muscle cell differentiation GO:1905064 8.96 MIR221 MIR100

Molecular functions related to Multisystem Inflammatory Syndrome in Children according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR99A MIR365A MIR221 MIR191 MIR100

Sources for Multisystem Inflammatory Syndrome in Children

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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