MGS
MCID: MNG003
MIFTS: 34

Mungan Syndrome (MGS)

Categories: Gastrointestinal diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Mungan Syndrome

MalaCards integrated aliases for Mungan Syndrome:

Name: Mungan Syndrome 57 53 13 6 73
Mgs 57 53
Visceral Neuromyopathy, Familial, with Pseudoobstruction, Megaduodenum, Barrett Esophagus, and Cardiac Abnormalities 57
Visceral Neuromyopathy Familial with Pseudoobstruction Megaduodenum Barrett Esophagus and Cardiac Abnormalities 53
Pseudoobstruction, Chronic Idiopathic Intestinal, with Barrett Esophagus and Cardiac Abnormalities 57
Pseudoobstruction Chronic Idiopathic Intestinal with Barrett Esophagus and Cardiac Abnormalities 53

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive

Miscellaneous:
based on report of 1 family (last curated august 2018)


HPO:

32
mungan syndrome:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Mungan Syndrome

MalaCards based summary : Mungan Syndrome, also known as mgs, is related to myasthenia gravis and hyperglycemia. An important gene associated with Mungan Syndrome is RAD21 (RAD21 Cohesin Complex Component). Affiliated tissues include bone, liver and lung, and related phenotypes are vesicoureteral reflux and renal hypoplasia

Wikipedia : 76 Mungan syndrome is first described in 2003 by Mungan Z. et al. as an autosomal recessively inherited... more...

Description from OMIM: 611376

Related Diseases for Mungan Syndrome

Diseases related to Mungan Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)
# Related Disease Score Top Affiliating Genes
1 myasthenia gravis 12.0
2 hyperglycemia 11.6
3 myasthenia gravis congenital 11.4
4 primary hypomagnesemia 11.4
5 hyperuricemia 11.4
6 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 11.3
7 hypnic headache 11.1
8 perrault syndrome 1 11.1
9 visceral myopathy 11.1
10 hypomagnesemia 3, renal 11.1
11 iron overload in africa 11.1
12 glucocorticoid-induced osteoporosis 11.1
13 fetal methylmercury syndrome 11.1
14 quinquaud's decalvans folliculitis 11.1
15 maturity-onset diabetes of the young, type 2 10.9
16 anencephaly 10.9
17 hyperphenylalaninemia, bh4-deficient, b 10.9
18 mucopolysaccharidosis, type vi 10.9
19 hyperphenylalaninemia, bh4-deficient, a 10.9
20 kearns-sayre syndrome 10.9
21 hypercholesterolemia, autosomal recessive 10.9
22 glut1 deficiency syndrome 1 10.9
23 aromatase deficiency 10.9
24 adenine phosphoribosyltransferase deficiency 10.9
25 familial hypocalciuric hypercalcemia 10.9
26 mild phenylketonuria 10.9
27 paroxysmal hemicrania 10.9
28 prostatic hyperplasia, benign 10.3
29 depression 10.3
30 osteoporosis 10.2
31 major depressive disorder 10.2
32 macular retinal edema 10.2
33 prostatic adenoma 10.2
34 astrocytoma 10.2
35 glioblastoma 10.2
36 hypertension, essential 10.2
37 rosacea 10.1
38 rheumatoid arthritis 10.1
39 urticaria 10.1
40 diabetic macular edema 10.1
41 arthritis 10.1
42 leukemia 10.1
43 venous insufficiency 10.1
44 allergic rhinitis 10.1
45 rhinitis 10.1
46 glioma 10.1
47 gastroesophageal reflux 10.1
48 prostate cancer 10.1
49 myocardial infarction 10.1
50 alopecia 10.1

Graphical network of the top 20 diseases related to Mungan Syndrome:



Diseases related to Mungan Syndrome

Symptoms & Phenotypes for Mungan Syndrome

Symptoms via clinical synopsis from OMIM:

57
Genitourinary Ureters:
vesicoureteral reflux

Head And Neck Eyes:
ptosis, bilateral

Cardiovascular Vascular:
supravalvular pulmonary stenosis, minimal

Neurologic Peripheral Nervous System:
visceral neuromyopathy

Genitourinary Kidneys:
renal hypoplasia

Cardiovascular Heart:
tricuspid valve regurgitation
ventricular septal defect, membranous
pulmonary valve regurgitation
pulmonary valve stenosis, minimal

Abdomen Gastrointestinal:
visceral neuromyopathy
pseudoobstruction
megaduodenum
barrett esophagus, long-segment
aperistalsis


Clinical features from OMIM:

611376

Human phenotypes related to Mungan Syndrome:

32 (show all 11)
# Description HPO Frequency HPO Source Accession
1 vesicoureteral reflux 32 HP:0000076
2 renal hypoplasia 32 HP:0000089
3 pulmonic stenosis 32 HP:0001642
4 tricuspid regurgitation 32 HP:0005180
5 intestinal pseudo-obstruction 32 HP:0004389
6 abnormality of the autonomic nervous system 32 HP:0002270
7 bilateral ptosis 32 HP:0001488
8 hypoperistalsis 32 HP:0100771
9 perimembranous ventricular septal defect 32 HP:0011682
10 barrett esophagus 32 HP:0100580
11 megaduodenum 32 HP:0030996

Drugs & Therapeutics for Mungan Syndrome

Search Clinical Trials , NIH Clinical Center for Mungan Syndrome

Genetic Tests for Mungan Syndrome

Anatomical Context for Mungan Syndrome

MalaCards organs/tissues related to Mungan Syndrome:

41
Bone, Liver, Lung, Heart, Prostate, Thyroid, Bone Marrow

Publications for Mungan Syndrome

Articles related to Mungan Syndrome:

(show all 17)
# Title Authors Year
1
High salt diet can down-regulate TFF2 expression level in gastric mucosa of MGs after H. pylori infection. ( 29601867 )
2018
2
Retrospective Comparative Study on Postoperative Pulmonary Complications After Orthotopic Liver Transplantation Using the Melbourne Group Scale (MGS-2) Diagnostic Criteria. ( 29853713 )
2018
3
Optimal clustering of MGs based on droop controller for improving reliability using a hybrid of harmony search and genetic algorithms. ( 26767800 )
2016
4
Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. ( 24610889 )
2014
5
Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes. ( 24726609 )
2014
6
Anionic lipid binding to the foreign protein MGS provides a tight coupling between phospholipid synthesis and protein overexpression in Escherichia coli. ( 23869703 )
2013
7
Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions. ( 19573206 )
2009
8
New transformation mechanism for a zinc-blende to rocksalt phase transformation in MgS. ( 21694004 )
2009
9
Dr. ordered 30 mgs Dilaudid: RN questioned order resulting in change. Case on point: Wall v. Hillside Hosp., 2008 TNCIV M2005-02529-COA-R-3 (01/31/2008) -TN. ( 18686890 )
2008
10
Treatment of lead mine waste by a Mozley multi-gravity separator (MGS). ( 15935546 )
2005
11
Photoluminescence and spectral holeburning in europium-doped MgS nanoparticles. ( 16375503 )
2005
12
First-principles study of the structural properties of MgS-, MgSe-, ZnS-, and ZnSe-based superlattices. ( 9981259 )
1995
13
Wolff's law: an 'MGS' derivation of Gamma in the Three-Way Rule for mechanically controlled lamellar bone modeling drifts. ( 8251764 )
1993
14
Infrared-to-visible conversion following sub-band-gap excitation in MgS:Eu,Sm. ( 9947835 )
1989
15
Evidence of V- centers in trivalent rare-earth doped MgS. ( 9945948 )
1988
16
The Reverend Joseph Townsend MA MGS (1739-1816) physician and geologist--'Colossus of Roads'. ( 4890357 )
1969
17
The MgS gene complex of the MNSs blood group system, evidenced in a Sicilian family. ( 5798089 )
1969

Variations for Mungan Syndrome

ClinVar genetic disease variations for Mungan Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RAD21 NM_006265.2(RAD21): c.1864G> A (p.Ala622Thr) single nucleotide variant Pathogenic rs775266057 GRCh38 Chromosome 8, 116847532: 116847532
2 RAD21 NM_006265.2(RAD21): c.1864G> A (p.Ala622Thr) single nucleotide variant Pathogenic rs775266057 GRCh37 Chromosome 8, 117859771: 117859771

Expression for Mungan Syndrome

Search GEO for disease gene expression data for Mungan Syndrome.

Pathways for Mungan Syndrome

GO Terms for Mungan Syndrome

Sources for Mungan Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....