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MCID: MRR003
MIFTS: 37

Murray Valley Encephalitis

Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Murray Valley Encephalitis

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MalaCards integrated aliases for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 12 15 72
Australian Encephalitis 12 33
Australian X Disease 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10842
ICD9CM 35 062.4
SNOMED-CT 68 66454007
ICD10 33 A83.4
UMLS 72 C0153066
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Summaries for Murray Valley Encephalitis

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Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary : Murray Valley Encephalitis, also known as australian encephalitis, is related to st. louis encephalitis and vaccinia, and has symptoms including fever, vomiting and confusion. An important gene associated with Murray Valley Encephalitis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include brain, brain and t cells.

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Related Diseases for Murray Valley Encephalitis

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Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 st. louis encephalitis 30.7 SNORA73B ERVW-1
2 vaccinia 29.3 IL2 IFNB1 IFNA1 ERVW-1
3 encephalitis 11.3
4 japanese encephalitis 10.9
5 west nile virus 10.6
6 adult pineoblastoma 10.5 DROSHA DICER1
7 adult pineal parenchymal tumor 10.5 DROSHA DICER1
8 viral encephalitis 10.5
9 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
10 dengue virus 10.3
11 locked-in syndrome 10.3
12 quadriplegia 10.3
13 yellow fever 10.3
14 exanthema subitum 10.3 IL2 CD40LG
15 atopic keratoconjunctivitis 10.3 IL3 IL2
16 cryoglobulinemia, familial mixed 10.3 IFNA1 CD40LG
17 breast abscess 10.3 IFNB1 CD40LG
18 retroperitoneal neuroblastoma 10.2 IL2 IFNB1
19 polykaryocytosis inducer 10.2
20 triiodothyronine receptor auxiliary protein 10.2
21 neuroblastoma 1 10.2
22 pulmonary alveolar microlithiasis 10.2
23 alacrima, achalasia, and mental retardation syndrome 10.2
24 louping ill 10.2
25 meningoencephalitis 10.2
26 respiratory failure 10.2
27 thrombocytosis 10.2
28 poliomyelitis 10.2
29 herpes simplex 10.2
30 bacterial meningitis 10.2
31 haemophilus influenzae 10.2
32 herpes simplex encephalitis 10.2
33 cerebral atrophy 10.2
34 tremor 10.2
35 oral erosive lichen 10.2 IFNB1 IFNA1
36 dysgerminoma of ovary 10.1 DICER1 CD40LG
37 herpangina 10.0 IFNB1 IFNA1
38 t-cell adult acute lymphocytic leukemia 10.0 IL2 ERVW-1
39 kyasanur forest disease 10.0 IFNA1 ERVW-1
40 demyelinating disease 9.9 IFNB1 IFNA1 CD40LG
41 newcastle disease 9.9 IFNB1 IFNA1
42 hairy cell leukemia 9.9 IL3 IL2 IFNA1
43 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 IL2 ERVW-1 CD40LG
44 autoimmune disease 9.8 IL2 IFNA1 CD40LG
45 spinal cord disease 9.8 IFNB1 ERVW-1
46 microphthalmia with limb anomalies 9.8 IFNB1 IFNA1
47 gerstmann-straussler disease 9.7 THY1 PRNP
48 measles 9.7 IL2 IFNB1 IFNA1
49 human immunodeficiency virus infectious disease 9.6 IL2 IFNA1 ERVW-1
50 hypersensitivity reaction type iv disease 9.6 IL2 IFNA1

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to Murray Valley Encephalitis
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Symptoms & Phenotypes for Murray Valley Encephalitis

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Symptoms:

12
  • • fever
  • • vomiting
  • • confusion
  • • headache
  • • nausea
  • • drowsiness
  • • weakness
  • • fitting
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Drugs & Therapeutics for Murray Valley Encephalitis

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Search Clinical Trials , NIH Clinical Center for Murray Valley Encephalitis

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Genetic Tests for Murray Valley Encephalitis

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Anatomical Context for Murray Valley Encephalitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Murray Valley Encephalitis:

19
Brain

MalaCards organs/tissues related to Murray Valley Encephalitis:

41
Brain, T Cells, Testes, B Cells, Kidney, Neutrophil
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Publications for Murray Valley Encephalitis

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Articles related to Murray Valley Encephalitis:

(show top 50) (show all 363)
# Title Authors PMID Year
1
Development and Field Evaluation of a System to Collect Mosquito Excreta for the Detection of Arboviruses. 38
30945738 2019
2
Evaluation of a new West Nile virus nucleic acid test for screening of blood donations. 38
30427542 2019
3
The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo. 38
30356234 2018
4
The challenges posed by equine arboviruses. 38
29517814 2018
5
The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis. 38
29891797 2018
6
Murray Valley Encephalitis Virus: An Ongoing Cause of Encephalitis in Australia's North. 38
30274445 2018
7
Cortical Neurons Derived from Equine Induced Pluripotent Stem Cells Are Susceptible to Neurotropic Flavivirus Infection and Replication: An In Vitro Model for Equine Neuropathic Diseases. 38
29562867 2018
8
Alfred Walter Campbell's return to Australia. 38
29173053 2018
9
Differential Diagnosis of Flavivirus Infections in Horses Using Viral Envelope Protein Domain III Antigens in Enzyme-Linked Immunosorbent Assay. 38
29083957 2017
10
Confronting the Emerging Threat to Public Health in Northern Australia of Neglected Indigenous Arboviruses. 38
30270912 2017
11
Neglected Australian arboviruses: quam gravis? 38
28552411 2017
12
The ecology and epidemiology of Ross River and Murray Valley encephalitis viruses in Western Australia: examples of One Health in Action. 38
29044370 2017
13
Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011. 38
28098530 2017
14
Exotic mosquito threats require strategic surveillance and response planning. 38
27997935 2016
15
Determining Culex annulirostris larval densities and control efforts across a coastal wetland, Northern Territory, Australia. 38
27860005 2016
16
Deployable Molecular Detection of Arboviruses in the Australian Outback. 38
27402516 2016
17
Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. 38
27061052 2016
18
Towards public health surveillance of intensive care services in NSW, Australia. 38
27421345 2016
19
A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections. 38
27233361 2016
20
Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea. 38
27086158 2016
21
Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. 38
26373772 2016
22
Arboviral diseases and malaria in Australia, 2012-13: Annual report of the National Arbovirus and Malaria Advisory Committee. 38
27080023 2016
23
End-point disease investigation for virus strains of intermediate virulence as illustrated by flavivirus infections. 38
26614392 2016
24
Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt? 38
26601912 2016
25
A Bayesian Belief Network for Murray Valley encephalitis virus risk assessment in Western Australia. 38
26823368 2016
26
Historical Perspective: What Constitutes Discovery (of a New Virus)? 38
27112283 2016
27
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. 38
26600318 2015
28
Development and field evaluation of the sentinel mosquito arbovirus capture kit (SMACK). 38
26444264 2015
29
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction. 38
26377679 2015
30
Functional non-coding RNAs derived from the flavivirus 3' untranslated region. 38
25660582 2015
31
Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control. 38
26184326 2015
32
Vectorial capacity of Culex gelidus (Theobald) mosquitoes to certain viruses of public health importance in India. 38
26119548 2015
33
The effect of riboflavin and ultraviolet light on the infectivity of arboviruses. 38
25370822 2015
34
A case of Murray Valley encephalitis in a 2-year-old Australian Stock Horse in south-east Queensland. 38
25708787 2015
35
Visual detection of murray valley encephalitis virus by reverse transcription loop-mediated isothermal amplification. 38
25800449 2015
36
Usutu virus: an emerging flavivirus in Europe. 38
25606971 2015
37
A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus. 38
26381398 2015
38
Safety and immunogenicity of a delta inulin-adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals. 38
25516480 2014
39
Replication potential and different modes of transmission of West Nile virus in an Indian strain of Culex gelidus Theobald (Diptera: Culicidae) mosquitoes. 38
25540967 2014
40
Culex gelidus: an emerging mosquito vector with potential to transmit multiple virus infections. 38
25540955 2014
41
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western Australia. 38
25490948 2014
42
Flavivirus detection and differentiation by a microsphere array assay. 38
24690622 2014
43
A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice. 38
25077483 2014
44
Complete genome sequences of the prototype isolates of genotypes 2, 3, and 4 of murray valley encephalitis virus. 38
24948762 2014
45
Aedes albopictus (Diptera: Culicidae) as a potential vector of endemic and exotic arboviruses in Australia. 38
24897860 2014
46
Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties. 38
24307589 2014
47
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. 38
24333681 2014
48
Recent weather extremes and impacts on agricultural production and vector-borne disease outbreak patterns. 38
24658301 2014
49
Arboviruses pathogenic for domestic and wild animals. 38
24751197 2014
50
The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. 38
24466360 2014
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Variations for Murray Valley Encephalitis

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Expression for Murray Valley Encephalitis

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Search GEO for disease gene expression data for Murray Valley Encephalitis.
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Pathways for Murray Valley Encephalitis

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Pathways related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 37 1
Show member pathways
 12.51 PRF1 IL3 IL2 IFNA1 CD40LG
2
NF-kappaB Signaling 4
12.25 IL3 IL2 IFNA1 CD40LG
3
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.07 IL3 IL2 IFNB1 IFNA1
4
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.97 IL3 IL2 IFNB1 IFNA1
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.72 THY1 IL3 IL2
6
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 11.5 PRF1 IL3 IL2 IFNB1 IFNA1
7
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.38 IL3 IL2 CD40LG
8
Dendritic Cells Developmental Lineage Pathway 65
11.3 THY1 IL2 IFNB1
9
Jak-Stat Signaling Pathway (sino) 67
11.2 IL3 IL2 IFNB1 IFNA1
10
Inflammatory Response Pathway 1
11.05 IL2 CD40LG
11
IL12 signaling mediated by STAT4 1
10.96 PRF1 IL2
12
G-protein signaling_RhoB regulation pathway 22
10.93 IL3 IL2 CD40LG
13
Cytokines and Inflammatory Response 1
10.79 IL3 IL2 IFNB1
14
DDX1 as a regulatory component of the Drosha microprocessor 1
Show member pathways
 10.7 DROSHA DICER1
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GO Terms for Murray Valley Encephalitis

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Cellular components related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 THY1 PRF1 IL3 IL2 IFNB1 IFNA1
2 anchored component of external side of plasma membrane GO:0031362 8.62 THY1 PRNP

Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.7 PRF1 IFNB1 IFNA1
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL3 IL2 IFNB1 IFNA1
3 response to exogenous dsRNA GO:0043330 9.54 IFNB1 IFNA1
4 natural killer cell activation GO:0030101 9.51 IL2 IFNB1
5 T cell activation involved in immune response GO:0002286 9.49 IFNB1 IFNA1
6 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.48 IFNB1 IFNA1
7 negative regulation of T cell receptor signaling pathway GO:0050860 9.46 THY1 PRNP
8 natural killer cell activation involved in immune response GO:0002323 9.43 IFNB1 IFNA1
9 regulation of regulatory T cell differentiation GO:0045589 9.4 IL2 DROSHA
10 miRNA metabolic process GO:0010586 9.37 DROSHA DICER1
11 pre-miRNA processing GO:0031054 9.32 DROSHA DICER1
12 production of siRNA involved in RNA interference GO:0030422 9.16 DROSHA DICER1
13 B cell differentiation GO:0030183 9.13 IFNB1 IFNA1 CD40LG
14 B cell proliferation GO:0042100 8.8 IFNB1 IFNA1 CD40LG

Molecular functions related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoribonuclease activity GO:0004521 9.32 DROSHA DICER1
2 cytokine receptor binding GO:0005126 9.26 IFNB1 IFNA1
3 type I interferon receptor binding GO:0005132 9.16 IFNB1 IFNA1
4 cytokine activity GO:0005125 9.02 IL3 IL2 IFNB1 IFNA1 CD40LG
5 ribonuclease III activity GO:0004525 8.96 DROSHA DICER1
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Sources for Murray Valley Encephalitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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