MCID: MRR003
MIFTS: 42

Murray Valley Encephalitis

Categories: Infectious diseases

Aliases & Classifications for Murray Valley Encephalitis

MalaCards integrated aliases for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 12 15 73
Australian Encephalitis 12
Australian X Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10842
ICD10 33 A83.4
ICD9CM 35 062.4
SNOMED-CT 68 66454007
UMLS 73 C0153066

Summaries for Murray Valley Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary : Murray Valley Encephalitis, also known as australian encephalitis, is related to louping ill and st. louis encephalitis, and has symptoms including fever, headache and nausea. An important gene associated with Murray Valley Encephalitis is RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Proteoglycans in cancer and C-type lectin receptor signaling pathway. Affiliated tissues include brain, brain and testes, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Murray Valley Encephalitis

Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 louping ill 29.7 CD40LG ERVW-1 STAB2
2 st. louis encephalitis 28.9 ERVW-1 KRAS RAF1 SNORA73B
3 encephalitis 11.2
4 zika fever 10.7 CD40LG RAF1
5 west nile fever 10.7 CD40LG STAB2
6 respiratory system benign neoplasm 10.7 KRAS RAF1
7 pulmonary blastoma 10.5 DICER1 KRAS
8 mononeuritis of upper limb and mononeuritis multiplex 10.5 CD40LG MYOM2
9 polyclonal hypergammaglobulinemia 10.5 CD40LG MYOM2
10 chronic polyneuropathy 10.5 CD40LG MYOM2
11 japanese encephalitis 10.5
12 la crosse encephalitis 10.5 CD40LG STAB2
13 non-secretory myeloma 10.5 CD40LG MYOM2
14 osteosclerotic myeloma 10.4 CD40LG MYOM2
15 immune defect due to absence of thymus 10.4 CD40LG IL2
16 mononeuropathy 10.4 CD40LG MYOM2
17 plasma protein metabolism disease 10.4 CD40LG MYOM2
18 monoclonal gammopathy of uncertain significance 10.4 CD40LG MYOM2
19 streptococcal toxic-shock syndrome 10.4 IL2 MYOM2
20 extramedullary plasmacytoma 10.3 IL2 MYOM2
21 west nile virus 10.3
22 streptococcal meningitis 10.3 CD40LG MYOM2
23 coccidiosis 10.3 CD40LG IL2
24 pulmonic stenosis 10.3 KRAS RAF1
25 plasma cell neoplasm 10.2 CD40LG MYOM2
26 necrotizing fasciitis 10.2 IL2 MYOM2
27 exanthema subitum 10.2 CD40LG IL2
28 exanthem 10.1 CD40LG IL2 KRAS
29 gerstmann-straussler disease 10.1 PRNP THY1
30 aging 10.0
31 poliomyelitis 10.0
32 herpes simplex 10.0
33 yellow fever 10.0
34 herpes simplex encephalitis 10.0
35 rheumatoid lung disease 10.0 CD40LG ERVW-1
36 commensal bacterial infectious disease 10.0 CD40LG IL2 MYOM2
37 hypersensitivity reaction type iv disease 10.0 CD40LG IL2 MYOM2
38 rheumatic fever 10.0 CD40LG IL2 MYOM2
39 phlebotomus fever 10.0 CD40LG ERVW-1
40 transient arthritis 9.9 CD40LG ERVW-1
41 progressive multifocal leukoencephalopathy 9.9 CD40LG IL2
42 spinal cord disease 9.7 CD40LG ERVW-1
43 myeloma, multiple 9.7 CD40LG IL2 KRAS MYOM2
44 human immunodeficiency virus infectious disease 9.5 CD40LG ERVW-1 IL2
45 immune deficiency disease 9.5 CD40LG ERVW-1 IL2
46 viral infectious disease 9.5 CD40LG ERVW-1 IL2
47 kyasanur forest disease 9.4 CD40LG ERVW-1 KRAS RAF1
48 trehalase deficiency 8.9 CD40LG KRAS PRNP RAF1

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to Murray Valley Encephalitis

Symptoms & Phenotypes for Murray Valley Encephalitis

Symptoms:

12
  • fever
  • headache
  • nausea
  • vomiting
  • drowsiness
  • confusion
  • fitting
  • weakness

MGI Mouse Phenotypes related to Murray Valley Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.98 IL2 KRAS CD40LG DICER1 RAF1 DROSHA
2 endocrine/exocrine gland MP:0005379 9.95 KRAS CD40LG PRNP DICER1 RAF1 DROSHA
3 integument MP:0010771 9.85 KRAS CD40LG PRNP DICER1 RAF1 DROSHA
4 liver/biliary system MP:0005370 9.8 KRAS DICER1 RAF1 DROSHA STAB2 IL2
5 muscle MP:0005369 9.73 KRAS PRNP DICER1 RAF1 DROSHA STAB2
6 neoplasm MP:0002006 9.55 IL2 KRAS DICER1 RAF1 STAB2
7 normal MP:0002873 9.5 THY1 KRAS PRNP DICER1 RAF1 DROSHA
8 respiratory system MP:0005388 9.17 KRAS DICER1 RAF1 DROSHA STAB2 IL2

Drugs & Therapeutics for Murray Valley Encephalitis

Search Clinical Trials , NIH Clinical Center for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

Anatomical Context for Murray Valley Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Murray Valley Encephalitis:

19
Brain

MalaCards organs/tissues related to Murray Valley Encephalitis:

41
Brain, Testes, Neutrophil, B Cells, Kidney

Publications for Murray Valley Encephalitis

Articles related to Murray Valley Encephalitis:

(show top 50) (show all 179)
# Title Authors Year
1
The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis. ( 29891797 )
2018
2
The ecology and epidemiology of Ross River and Murray Valley encephalitis viruses in Western Australia: examples of One Health in Action. ( 29044370 )
2017
3
Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011. ( 28098530 )
2017
4
Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea. ( 27086158 )
2016
5
A Bayesian Belief Network for Murray Valley encephalitis virus risk assessment in Western Australia. ( 26823368 )
2016
6
Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt? ( 26601912 )
2016
7
A case of Murray Valley encephalitis in a 2-year-old Australian Stock Horse in south-east Queensland. ( 25708787 )
2015
8
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. ( 26600318 )
2015
9
Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. ( 26373772 )
2015
10
Visual detection of murray valley encephalitis virus by reverse transcription loop-mediated isothermal amplification. ( 25800449 )
2015
11
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction. ( 26377679 )
2015
12
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western Australia. ( 25490948 )
2014
13
The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. ( 24466360 )
2014
14
Complete genome sequences of the prototype isolates of genotypes 2, 3, and 4 of murray valley encephalitis virus. ( 24948762 )
2014
15
Low seroprevalence of Murray Valley encephalitis and Kunjin viruses in an opportunistic serosurvey, Victoria 2011. ( 24090325 )
2013
16
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. ( 24333681 )
2013
17
Molecular characterization and phylogenetic analysis of Murray Valley encephalitis virus and West Nile virus (Kunjin subtype) from an arbovirus disease outbreak in horses in Victoria, Australia, in 2011. ( 23345269 )
2013
18
A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cells. ( 23460804 )
2013
19
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study. ( 23974013 )
2013
20
Clinical and radiological predictors of outcome for Murray Valley encephalitis. ( 23296449 )
2013
21
Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse. ( 22379060 )
2012
22
Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease. ( 22991186 )
2012
23
Opportunistic serological surveillance for Murray Valley encephalitis virus in Victoria, February-May 2011. ( 22860790 )
2012
24
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. ( 22432670 )
2012
25
Biochemical characterisation of Murray Valley encephalitis virus proteinase. ( 20621842 )
2010
26
Factsheet: Murray Valley encephalitis. ( 21604606 )
2010
27
Influence of hosts on the ecology of arboviral transmission: potential mechanisms influencing dengue, Murray Valley encephalitis, and Ross River virus in Australia. ( 18800866 )
2009
28
Murray Valley encephalitis virus. ( 20191691 )
2009
29
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. ( 19109382 )
2009
30
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972-2003. ( 17393295 )
2007
31
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. ( 17622627 )
2007
32
Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature. ( 17161855 )
2007
33
In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein. ( 17374761 )
2007
34
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. ( 17893366 )
2007
35
Murray valley encephalitis mimicking herpes simplex encephalitis. ( 16169227 )
2005
36
Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus. ( 14991436 )
2004
37
Epizootic activity of Murray Valley encephalitis and Kunjin viruses in an aboriginal community in the southeast Kimberley region of Western Australia: results of mosquito fauna and virus isolation studies. ( 14628944 )
2003
38
Clinical and laboratory findings on the first imported case of Murray Valley encephalitis in Europe. ( 12856229 )
2003
39
MR findings in Murray Valley encephalitis. ( 12917132 )
2003
40
Polymerase chain reaction tests for the identification of Ross River, Kunjin and Murray Valley encephalitis virus infections in horses. ( 15084017 )
2003
41
Murray Valley encephalitis: case report and review of neuroradiological features. ( 12581057 )
2003
42
Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. ( 12810865 )
2003
43
Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. ( 11967307 )
2002
44
Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. ( 12408675 )
2002
45
Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season. ( 12653302 )
2002
46
Murray Valley encephalitis virus recombinant subviral particles protect mice from lethal challenge with virulent wild-type virus. ( 12111426 )
2002
47
Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. ( 11950201 )
2002
48
Murray Valley encephalitis in Mt Isa, north Queensland. Tropical Public Health Unit Network, Queensland Health. ( 11432525 )
2001
49
Murray valley encephalitis. ( 11596721 )
2001
50
Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein. ( 11462041 )
2001

Variations for Murray Valley Encephalitis

Expression for Murray Valley Encephalitis

Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for Murray Valley Encephalitis

GO Terms for Murray Valley Encephalitis

Cellular components related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of external side of plasma membrane GO:0031362 8.62 PRNP THY1

Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.71 CD40LG IL2 PRNP RAF1
2 positive regulation of protein phosphorylation GO:0001934 9.54 IL2 KRAS RAF1
3 RNA phosphodiester bond hydrolysis GO:0090501 9.43 DICER1 DROSHA
4 negative regulation of T cell receptor signaling pathway GO:0050860 9.32 PRNP THY1
5 miRNA metabolic process GO:0010586 9.26 DICER1 DROSHA
6 regulation of regulatory T cell differentiation GO:0045589 9.16 DROSHA IL2
7 pre-miRNA processing GO:0031054 8.96 DICER1 DROSHA
8 production of siRNA involved in RNA interference GO:0030422 8.62 DICER1 DROSHA

Molecular functions related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoribonuclease activity GO:0004521 8.96 DICER1 DROSHA
2 ribonuclease III activity GO:0004525 8.62 DICER1 DROSHA

Sources for Murray Valley Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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