MCID: MRR003
MIFTS: 41

Murray Valley Encephalitis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Murray Valley Encephalitis

MalaCards integrated aliases for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 12 15 74
Australian Encephalitis 12
Australian X Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10842
ICD9CM 36 062.4
SNOMED-CT 69 66454007
ICD10 34 A83.4
UMLS 74 C0153066

Summaries for Murray Valley Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary : Murray Valley Encephalitis, also known as australian encephalitis, is related to louping ill and st. louis encephalitis, and has symptoms including fever, vomiting and confusion. An important gene associated with Murray Valley Encephalitis is STAB2 (Stabilin 2), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include brain, testes and kidney, and related phenotypes are neoplasm and normal

Related Diseases for Murray Valley Encephalitis

Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 louping ill 30.5 ERVW-1 STAB2
2 st. louis encephalitis 30.4 ERVW-1 SNORA73B
3 encephalitis 11.3
4 japanese encephalitis 10.6
5 noonan syndrome 3 10.5
6 west nile virus 10.4
7 adult pineal parenchymal tumor 10.3 DICER1 DROSHA
8 adult pineoblastoma 10.3 DICER1 DROSHA
9 noonan syndrome 5 10.3
10 anemia of prematurity 10.2 IL3 STAB2
11 atopic keratoconjunctivitis 10.2 IL2 IL3
12 poliomyelitis 10.2
13 herpes simplex 10.2
14 yellow fever 10.2
15 herpes simplex encephalitis 10.2
16 retroperitoneal neuroblastoma 10.2 IFNB1 IL2
17 la crosse encephalitis 10.2 IFNB1 STAB2
18 oral erosive lichen 10.1 IFNA1 IFNB1
19 farmer's lung 10.1 IL2 PI3
20 balanoposthitis 10.1 IL2 PI3
21 engraftment syndrome 10.0 IFNA1 PI3
22 herpangina 10.0 IFNA1 IFNB1
23 t-cell adult acute lymphocytic leukemia 10.0 ERVW-1 IL2
24 kyasanur forest disease 10.0 ERVW-1 IFNA1
25 hairy cell leukemia 9.9 IFNA1 IL2 IL3
26 microphthalmia with limb anomalies 9.9 IFNA1 IFNB1
27 measles 9.9 IFNA1 IFNB1 IL2
28 newcastle disease 9.9 IFNA1 IFNB1
29 gerstmann-straussler disease 9.8 PRNP THY1
30 human immunodeficiency virus infectious disease 9.8 ERVW-1 IFNA1 IL2
31 spinal cord disease 9.7 ERVW-1 IFNB1
32 viral infectious disease 9.6 ERVW-1 IFNA1 IFNB1 IL2
33 vaccinia 9.5 ERVW-1 IFNA1 IFNB1 IL2
34 noonan syndrome 1 9.5 ERVW-1 IFNA1 IFNB1 IL2
35 multiple sclerosis 9.4 ERVW-1 IFNA1 IFNB1 IL2 PRF1

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to Murray Valley Encephalitis

Symptoms & Phenotypes for Murray Valley Encephalitis

Symptoms:

12
  • fever
  • vomiting
  • confusion
  • headache
  • nausea
  • drowsiness
  • weakness
  • fitting

MGI Mouse Phenotypes related to Murray Valley Encephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 DICER1 IFNB1 IL2 PRF1 STAB2
2 normal MP:0002873 9.17 DICER1 DROSHA IFNB1 PRF1 PRNP STAB2

Drugs & Therapeutics for Murray Valley Encephalitis

Search Clinical Trials , NIH Clinical Center for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

Anatomical Context for Murray Valley Encephalitis

MalaCards organs/tissues related to Murray Valley Encephalitis:

42
Brain, Testes, Kidney, Neutrophil, B Cells, Lung, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Murray Valley Encephalitis:

20
Brain

Publications for Murray Valley Encephalitis

Articles related to Murray Valley Encephalitis:

(show top 50) (show all 185)
# Title Authors Year
1
Murray Valley Encephalitis Virus: An Ongoing Cause of Encephalitis in Australia's North. ( 30274445 )
2018
2
The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis. ( 29891797 )
2018
3
The ecology and epidemiology of Ross River and Murray Valley encephalitis viruses in Western Australia: examples of One Health in Action. ( 29044370 )
2017
4
Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011. ( 28098530 )
2017
5
Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea. ( 27086158 )
2016
6
A Bayesian Belief Network for Murray Valley encephalitis virus risk assessment in Western Australia. ( 26823368 )
2016
7
Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt? ( 26601912 )
2016
8
Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. ( 26373772 )
2016
9
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. ( 26600318 )
2015
10
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction. ( 26377679 )
2015
11
A case of Murray Valley encephalitis in a 2-year-old Australian Stock Horse in south-east Queensland. ( 25708787 )
2015
12
Visual detection of murray valley encephalitis virus by reverse transcription loop-mediated isothermal amplification. ( 25800449 )
2015
13
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. ( 24333681 )
2014
14
The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. ( 24466360 )
2014
15
Complete genome sequences of the prototype isolates of genotypes 2, 3, and 4 of murray valley encephalitis virus. ( 24948762 )
2014
16
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western Australia. ( 25490948 )
2014
17
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study. ( 23974013 )
2013
18
Low seroprevalence of Murray Valley encephalitis and Kunjin viruses in an opportunistic serosurvey, Victoria 2011. ( 24090325 )
2013
19
A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cells. ( 23460804 )
2013
20
Molecular characterization and phylogenetic analysis of Murray Valley encephalitis virus and West Nile virus (Kunjin subtype) from an arbovirus disease outbreak in horses in Victoria, Australia, in 2011. ( 23345269 )
2013
21
Clinical and radiological predictors of outcome for Murray Valley encephalitis. ( 23296449 )
2013
22
Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease. ( 22991186 )
2012
23
Opportunistic serological surveillance for Murray Valley encephalitis virus in Victoria, February-May 2011. ( 22860790 )
2012
24
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. ( 22432670 )
2012
25
Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse. ( 22379060 )
2012
26
Factsheet: Murray Valley encephalitis. ( 21604606 )
2010
27
Biochemical characterisation of Murray Valley encephalitis virus proteinase. ( 20621842 )
2010
28
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. ( 19109382 )
2009
29
Murray Valley encephalitis virus. ( 20191691 )
2009
30
Influence of hosts on the ecology of arboviral transmission: potential mechanisms influencing dengue, Murray Valley encephalitis, and Ross River virus in Australia. ( 18800866 )
2009
31
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. ( 17893366 )
2007
32
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. ( 17622627 )
2007
33
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972-2003. ( 17393295 )
2007
34
In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein. ( 17374761 )
2007
35
Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature. ( 17161855 )
2007
36
Murray valley encephalitis mimicking herpes simplex encephalitis. ( 16169227 )
2005
37
Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus. ( 14991436 )
2004
38
MR findings in Murray Valley encephalitis. ( 12917132 )
2003
39
Clinical and laboratory findings on the first imported case of Murray Valley encephalitis in Europe. ( 12856229 )
2003
40
Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. ( 12810865 )
2003
41
Murray Valley encephalitis: case report and review of neuroradiological features. ( 12581057 )
2003
42
Polymerase chain reaction tests for the identification of Ross River, Kunjin and Murray Valley encephalitis virus infections in horses. ( 15084017 )
2003
43
Epizootic activity of Murray Valley encephalitis and Kunjin viruses in an aboriginal community in the southeast Kimberley region of Western Australia: results of mosquito fauna and virus isolation studies. ( 14628944 )
2003
44
Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season. ( 12653302 )
2002
45
Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. ( 12408675 )
2002
46
Murray Valley encephalitis virus recombinant subviral particles protect mice from lethal challenge with virulent wild-type virus. ( 12111426 )
2002
47
Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. ( 11950201 )
2002
48
Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. ( 11967307 )
2002
49
Australian encephalitis: sentinel chicken surveillance programme. ( 11432527 )
2001
50
Australian encephalitis: Sentinel Chicken Surveillance Programme. ( 11596723 )
2001

Variations for Murray Valley Encephalitis

Expression for Murray Valley Encephalitis

Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for Murray Valley Encephalitis

GO Terms for Murray Valley Encephalitis

Cellular components related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 IFNA1 IFNB1 IL2 IL3 PI3 PRF1
2 anchored component of external side of plasma membrane GO:0031362 8.62 PRNP THY1

Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.78 IFNA1 IFNB1 IL2 IL3
2 defense response to virus GO:0051607 9.69 IFNA1 IFNB1 PRF1
3 B cell proliferation GO:0042100 9.54 IFNA1 IFNB1
4 response to exogenous dsRNA GO:0043330 9.52 IFNA1 IFNB1
5 natural killer cell activation GO:0030101 9.49 IFNB1 IL2
6 T cell activation involved in immune response GO:0002286 9.46 IFNA1 IFNB1
7 negative regulation of T cell receptor signaling pathway GO:0050860 9.43 PRNP THY1
8 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.4 IFNA1 IFNB1
9 natural killer cell activation involved in immune response GO:0002323 9.37 IFNA1 IFNB1
10 miRNA metabolic process GO:0010586 9.32 DICER1 DROSHA
11 regulation of regulatory T cell differentiation GO:0045589 9.26 DROSHA IL2
12 cytokine-mediated signaling pathway GO:0019221 9.26 IFNA1 IFNB1 IL2 IL3
13 pre-miRNA processing GO:0031054 9.16 DICER1 DROSHA
14 production of siRNA involved in RNA interference GO:0030422 8.62 DICER1 DROSHA

Molecular functions related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.32 IFNA1 IFNB1
2 endoribonuclease activity GO:0004521 9.26 DICER1 DROSHA
3 cytokine activity GO:0005125 9.26 IFNA1 IFNB1 IL2 IL3
4 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNB1
5 ribonuclease III activity GO:0004525 8.62 DICER1 DROSHA

Sources for Murray Valley Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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