MCID: MRR003
MIFTS: 41

Murray Valley Encephalitis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Murray Valley Encephalitis

MalaCards integrated aliases for Murray Valley Encephalitis:

Name: Murray Valley Encephalitis 12 15 73
Australian Encephalitis 12
Australian X Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10842
ICD10 33 A83.4
ICD9CM 35 062.4
SNOMED-CT 68 66454007
UMLS 73 C0153066

Summaries for Murray Valley Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in Murray Valley encephalitis virus, which is transmitted by Culex annulirostris mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom drowsiness, has symptom confusion, has symptom fitting, and has symptom weakness.

MalaCards based summary : Murray Valley Encephalitis, also known as australian encephalitis, is related to st. louis encephalitis and louping ill, and has symptoms including fever, vomiting and headache. An important gene associated with Murray Valley Encephalitis is STAB2 (Stabilin 2), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and JAK-STAT signaling pathway (KEGG). Affiliated tissues include brain, testes and kidney, and related phenotypes are normal and respiratory system

Related Diseases for Murray Valley Encephalitis

Diseases related to Murray Valley Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 st. louis encephalitis 30.4 SNORA73B ERVW-1
2 louping ill 30.4 STAB2 ERVW-1
3 viral infectious disease 30.2 IL2 IFNB1 IFNA1 ERVW-1
4 encephalitis 11.3
5 japanese encephalitis 10.6
6 west nile virus 10.4
7 adult pineoblastoma 10.2 DROSHA DICER1
8 adult pineal parenchymal tumor 10.2 DROSHA DICER1
9 poliomyelitis 10.2
10 herpes simplex 10.2
11 yellow fever 10.2
12 herpes simplex encephalitis 10.2
13 la crosse encephalitis 10.1 STAB2 IFNB1
14 retroperitoneal neuroblastoma 10.1 IL2 IFNB1
15 farmer's lung 10.1 PI3 IL2
16 oral erosive lichen 10.1 IFNB1 IFNA1
17 balanoposthitis 10.1 PI3 IL2
18 engraftment syndrome 10.0 PI3 IFNA1
19 herpangina 10.0 IFNB1 IFNA1
20 testicular disease 10.0 IL2 DICER1
21 t-cell adult acute lymphocytic leukemia 10.0 IL2 ERVW-1
22 kyasanur forest disease 10.0 IFNA1 ERVW-1
23 newcastle disease 10.0 IFNB1 IFNA1
24 microphthalmia with limb anomalies 10.0 IFNB1 IFNA1
25 hypersensitivity reaction type iv disease 10.0 IL2 IFNA1
26 spinal cord disease 10.0 IFNB1 ERVW-1
27 gerstmann-straussler disease 9.9 THY1 PRNP
28 measles 9.9 IL2 IFNB1 IFNA1
29 severe acute respiratory syndrome 9.9 IFNB1 IFNA1
30 autoimmune disease of central nervous system 9.9 IL2 IFNB1
31 human immunodeficiency virus infectious disease 9.9 IL2 IFNA1 ERVW-1
32 vaccinia 9.7 IL2 IFNB1 IFNA1 ERVW-1
33 noonan syndrome 1 9.7 IL2 IFNB1 IFNA1 ERVW-1
34 multiple sclerosis 9.7 IL2 IFNB1 IFNA1 ERVW-1

Graphical network of the top 20 diseases related to Murray Valley Encephalitis:



Diseases related to Murray Valley Encephalitis

Symptoms & Phenotypes for Murray Valley Encephalitis

Symptoms:

12
  • fever
  • vomiting
  • headache
  • confusion
  • drowsiness
  • nausea
  • weakness
  • fitting

MGI Mouse Phenotypes related to Murray Valley Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.43 DICER1 DROSHA IFNB1 PRNP STAB2 THY1
2 respiratory system MP:0005388 9.02 DICER1 DROSHA IL2 STAB2 THY1

Drugs & Therapeutics for Murray Valley Encephalitis

Search Clinical Trials , NIH Clinical Center for Murray Valley Encephalitis

Genetic Tests for Murray Valley Encephalitis

Anatomical Context for Murray Valley Encephalitis

MalaCards organs/tissues related to Murray Valley Encephalitis:

41
Brain, Testes, Kidney, Lung, Spinal Cord, T Cells, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Murray Valley Encephalitis:

19
Brain

Publications for Murray Valley Encephalitis

Articles related to Murray Valley Encephalitis:

(show top 50) (show all 185)
# Title Authors Year
1
The First Isolation and Whole Genome Sequencing of Murray Valley Encephalitis Virus from Cerebrospinal Fluid of a Patient with Encephalitis. ( 29891797 )
2018
2
Murray Valley Encephalitis Virus: An Ongoing Cause of Encephalitis in Australia's North. ( 30274445 )
2018
3
The ecology and epidemiology of Ross River and Murray Valley encephalitis viruses in Western Australia: examples of One Health in Action. ( 29044370 )
2017
4
Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011. ( 28098530 )
2017
5
Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea. ( 27086158 )
2016
6
A Bayesian Belief Network for Murray Valley encephalitis virus risk assessment in Western Australia. ( 26823368 )
2016
7
Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt? ( 26601912 )
2016
8
A case of Murray Valley encephalitis in a 2-year-old Australian Stock Horse in south-east Queensland. ( 25708787 )
2015
9
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. ( 26600318 )
2015
10
Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. ( 26373772 )
2015
11
Visual detection of murray valley encephalitis virus by reverse transcription loop-mediated isothermal amplification. ( 25800449 )
2015
12
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1-2A junction. ( 26377679 )
2015
13
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western Australia. ( 25490948 )
2014
14
The changing epidemiology of Murray Valley encephalitis in Australia: the 2011 outbreak and a review of the literature. ( 24466360 )
2014
15
Complete genome sequences of the prototype isolates of genotypes 2, 3, and 4 of murray valley encephalitis virus. ( 24948762 )
2014
16
Low seroprevalence of Murray Valley encephalitis and Kunjin viruses in an opportunistic serosurvey, Victoria 2011. ( 24090325 )
2013
17
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. ( 24333681 )
2013
18
Molecular characterization and phylogenetic analysis of Murray Valley encephalitis virus and West Nile virus (Kunjin subtype) from an arbovirus disease outbreak in horses in Victoria, Australia, in 2011. ( 23345269 )
2013
19
A new insect-specific flavivirus from northern Australia suppresses replication of West Nile virus and Murray Valley encephalitis virus in co-infected mosquito cells. ( 23460804 )
2013
20
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study. ( 23974013 )
2013
21
Clinical and radiological predictors of outcome for Murray Valley encephalitis. ( 23296449 )
2013
22
Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse. ( 22379060 )
2012
23
Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease. ( 22991186 )
2012
24
Opportunistic serological surveillance for Murray Valley encephalitis virus in Victoria, February-May 2011. ( 22860790 )
2012
25
Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. ( 22432670 )
2012
26
Biochemical characterisation of Murray Valley encephalitis virus proteinase. ( 20621842 )
2010
27
Factsheet: Murray Valley encephalitis. ( 21604606 )
2010
28
Influence of hosts on the ecology of arboviral transmission: potential mechanisms influencing dengue, Murray Valley encephalitis, and Ross River virus in Australia. ( 18800866 )
2009
29
Murray Valley encephalitis virus. ( 20191691 )
2009
30
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. ( 19109382 )
2009
31
Genetic and phenotypic differences between isolates of Murray Valley encephalitis virus in Western Australia, 1972-2003. ( 17393295 )
2007
32
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. ( 17622627 )
2007
33
Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature. ( 17161855 )
2007
34
In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein. ( 17374761 )
2007
35
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. ( 17893366 )
2007
36
Murray valley encephalitis mimicking herpes simplex encephalitis. ( 16169227 )
2005
37
Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus. ( 14991436 )
2004
38
Epizootic activity of Murray Valley encephalitis and Kunjin viruses in an aboriginal community in the southeast Kimberley region of Western Australia: results of mosquito fauna and virus isolation studies. ( 14628944 )
2003
39
Clinical and laboratory findings on the first imported case of Murray Valley encephalitis in Europe. ( 12856229 )
2003
40
MR findings in Murray Valley encephalitis. ( 12917132 )
2003
41
Polymerase chain reaction tests for the identification of Ross River, Kunjin and Murray Valley encephalitis virus infections in horses. ( 15084017 )
2003
42
Murray Valley encephalitis: case report and review of neuroradiological features. ( 12581057 )
2003
43
Antibody-dependent enhancement of Murray Valley encephalitis virus virulence in mice. ( 12810865 )
2003
44
Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. ( 11967307 )
2002
45
Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. ( 12408675 )
2002
46
Investigation of the southern limits of Murray Valley encephalitis activity in Western Australia during the 2000 wet season. ( 12653302 )
2002
47
Murray Valley encephalitis virus recombinant subviral particles protect mice from lethal challenge with virulent wild-type virus. ( 12111426 )
2002
48
Reappearance of human cases due to Murray Valley encephalitis virus and Kunjin virus in central Australia after an absence of 26 years. ( 11950201 )
2002
49
Murray Valley encephalitis in Mt Isa, north Queensland. Tropical Public Health Unit Network, Queensland Health. ( 11432525 )
2001
50
Murray valley encephalitis. ( 11596721 )
2001

Variations for Murray Valley Encephalitis

Expression for Murray Valley Encephalitis

Search GEO for disease gene expression data for Murray Valley Encephalitis.

Pathways for Murray Valley Encephalitis

GO Terms for Murray Valley Encephalitis

Cellular components related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of external side of plasma membrane GO:0031362 8.62 PRNP THY1

Biological processes related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.71 IFNA1 IFNB1 IL2
2 cytokine-mediated signaling pathway GO:0019221 9.7 IFNA1 IFNB1 IL2
3 RNA phosphodiester bond hydrolysis GO:0090501 9.51 DICER1 DROSHA
4 B cell proliferation GO:0042100 9.49 IFNA1 IFNB1
5 response to exogenous dsRNA GO:0043330 9.48 IFNA1 IFNB1
6 natural killer cell activation GO:0030101 9.46 IFNB1 IL2
7 T cell activation involved in immune response GO:0002286 9.43 IFNA1 IFNB1
8 negative regulation of T cell receptor signaling pathway GO:0050860 9.4 PRNP THY1
9 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.37 IFNA1 IFNB1
10 natural killer cell activation involved in immune response GO:0002323 9.32 IFNA1 IFNB1
11 miRNA metabolic process GO:0010586 9.26 DICER1 DROSHA
12 regulation of regulatory T cell differentiation GO:0045589 9.16 DROSHA IL2
13 pre-miRNA processing GO:0031054 8.96 DICER1 DROSHA
14 production of siRNA involved in RNA interference GO:0030422 8.62 DICER1 DROSHA

Molecular functions related to Murray Valley Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 IFNA1 IFNB1 IL2
2 cytokine receptor binding GO:0005126 9.26 IFNA1 IFNB1
3 endoribonuclease activity GO:0004521 9.16 DICER1 DROSHA
4 type I interferon receptor binding GO:0005132 8.96 IFNA1 IFNB1
5 ribonuclease III activity GO:0004525 8.62 DICER1 DROSHA

Sources for Murray Valley Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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