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MCID: MYC012
MIFTS: 48

Mycetoma

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mycetoma

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MalaCards integrated aliases for Mycetoma:

Name: Mycetoma 53 59 73
Madura Foot 53 59
Mycetoma of Foot 73

Characteristics:

Orphanet epidemiological data:

59
mycetoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA2583
MESH via Orphanet 45 D008271
UMLS via Orphanet 74 C0024449
ICD10 via Orphanet 34 B47.0 B47.1 B47.9
ICD10 33 B47 B47.9
Sources

Summaries for Mycetoma

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NIH Rare Diseases : 53 Mycetoma is a chronic infection that is caused by fungi or actinomycetes (bacteria that produce filaments, like fungi). The first symptom of the condition is generally painless swelling beneath the skin, which progresses to a nodule (lump) over several years. Eventually, affected people experience massive swelling and hardening of the affected area; skin rupture; and formation of sinus tracts (holes) that discharge pus and grains filled with organisms. Some affected people have no discomfort while others report itching and/or pain. Mycetoma is rare in the United States, but is commonly diagnosed in Africa, Mexico and India. In these countries, it occurs most frequently in farmers, shepherds, and people living in rural areas. Frequent exposure to penetrating wounds by thorns or splinters is a risk factor. Treatment varies based on the cause of the condition and may include antibiotics or antifungal medications.

MalaCards based summary : Mycetoma, also known as madura foot, is related to eumycotic mycetoma and pneumonia. An important gene associated with Mycetoma is CHIT1 (Chitinase 1), and among its related pathways/superpathways are Insulin receptor recycling and Immune response CCR3 signaling in eosinophils. The drugs Itraconazole and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotype is renal/urinary system.

Wikipedia : 76 Mycetoma is a term for a chronic subcutaneous infection caused by aerobic actinomycetic bacteria... more...

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Related Diseases for Mycetoma

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Diseases related to Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 eumycotic mycetoma 34.2 CCL5 CR1 TPT1
2 pneumonia 29.7 CCL5 CXCL8 IL10
3 lung disease 29.3 CCL5 CXCL8 CXCR2 IL10 MMP9
4 actinomycosis 11.6
5 whiplash 10.2 CCL5 COMT
6 transsexualism 10.2 CYP17A1 CYP19A1
7 ross river fever 10.2 COMT IL10
8 aspergillosis 10.1
9 periapical granuloma 10.1 CCL5 CXCL8
10 tungiasis 10.1 CXCL8 IL10
11 pouchitis 10.1 CXCL8 IL10
12 scabies 10.1 CXCL8 IL10
13 neurosyphilis 10.1 CXCL8 IL10
14 testicular leydig cell tumor 10.1 CYP17A1 HSD3B1
15 necatoriasis 10.1 CXCL8 IL10
16 filariasis 10.1 CCL5 CHIT1 IL10
17 trichuriasis 10.1 CXCL8 IL10
18 plasmodium falciparum malaria 10.1 CHIT1 CR1 IL10
19 chromoblastomycosis 10.1
20 nocardiosis 10.1
21 funisitis 10.1 CXCL8 IL10
22 hemangioma 10.1
23 fibromatosis 10.1
24 ledderhose disease 10.1
25 vulvovaginitis 10.1 CCL5 CXCL8 IL10
26 lipoid congenital adrenal hyperplasia 10.1 CYP17A1 CYP19A1 HSD3B1
27 vibratory urticaria 10.1 CXCL8 MMP9
28 clonorchiasis 10.1 CXCL8 IL10
29 bronchiolitis 10.1 CCL5 CXCL8 IL10
30 extrinsic allergic alveolitis 10.1 CCL5 CXCL8 IL10
31 upper respiratory tract disease 10.1 CCL5 CXCL8 IL10
32 bronchial disease 10.1 CCL5 CXCL8 IL10
33 trypanosomiasis 10.1 CCL5 CXCL8 IL10
34 osteomyelitis 10.0
35 sporotrichosis 10.0
36 pneumothorax 10.0
37 mammographic density 10.0 COMT CYP17A1 CYP19A1 CYP1B1
38 hemophagocytic lymphohistiocytosis 10.0 CR1 CXCL8 IL10
39 breast disease 10.0 COMT CYP19A1 CYP1B1
40 retinitis pigmentosa 44 10.0 CXCL8 IL10
41 idiopathic achalasia 10.0 IL10 NOS2
42 viral infectious disease 10.0 CCL5 CXCL8 IL10
43 acute pyelonephritis 10.0 CXCL8 CXCR2 IL10
44 pyelonephritis 10.0 CXCL8 CXCR2 IL10
45 cryptogenic organizing pneumonia 10.0 CXCL8 MMP9
46 crohn's colitis 10.0 CXCL8 NOS2
47 hemorrhoid 10.0 MMP9 NOS2
48 internal hemorrhoid 10.0 MMP9 NOS2
49 dermatitis, atopic 10.0 CCL5 CSN1S1 CXCL8 IL10
50 female reproductive system disease 10.0 CXCL8 CYP19A1 MMP9

Graphical network of the top 20 diseases related to Mycetoma:



Diseases related to Mycetoma
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Symptoms & Phenotypes for Mycetoma

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MGI Mouse Phenotypes related to Mycetoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 COMT CXCR2 CYP17A1 CYP19A1 MMP9 NOS2
Sources

Drugs & Therapeutics for Mycetoma

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Drugs for Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Itraconazole Approved, Investigational Phase 4,Phase 2 84625-61-6 55283
2
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
4 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
5 Antitussive Agents Phase 4
6 Hormone Antagonists Phase 4,Phase 2
7 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
8 Steroid Synthesis Inhibitors Phase 4,Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
10
Hydroxyitraconazole Phase 4,Phase 2
11 Antifungal Agents Phase 4,Phase 2
12 Hormones Phase 4,Phase 2
13 Anti-Infective Agents Phase 4,Phase 2
14 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
2 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Mycetoma

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Genetic Tests for Mycetoma

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Anatomical Context for Mycetoma

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MalaCards organs/tissues related to Mycetoma:

41
Skin, Lung, Bone, Kidney, Prostate, Brain, Eye
Sources

Publications for Mycetoma

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Articles related to Mycetoma:

(show top 50) (show all 744)
# Title Authors Year
1
Chronic Madura foot: mycetoma and/or <i>Actinomyces</i> spp or actinomycosis. ( 29789306 )
2018
2
A holistic approach to the mycetoma management. ( 29746460 )
2018
3
Cutaneous tuberculosis mimicking a mycetoma. ( 29882520 )
2018
4
Mycetoma: reviewing a neglected disease. ( 29808607 )
2018
5
Mycetoma in the Togolese: An Update from a Single-Center Experience. ( 29557534 )
2018
6
Case 249: Intramuscular Mycetoma. ( 29261466 )
2018
7
Staphylococcal infection of lower leg mimicking mycetoma. ( 29869404 )
2018
8
VNTR confirms the heterogeneity of Madurella mycetomatis and is a promising typing tool for this mycetoma causing agent. ( 30085253 )
2018
9
Mycetoma: a clinical dilemma in resource limited settings. ( 30097030 )
2018
10
Experimental Treatment of a Suspected Case of Mycetoma Based on Dot-in-Circle Sign. ( 30214112 )
2018
11
Mycetoma: The Spectrum of Clinical Presentation. ( 30274493 )
2018
12
The disabling consequences of Mycetoma. ( 30532253 )
2018
13
Madura foot: an imported case of a non-common diagnosis. ( 29932092 )
2018
14
Treatment of Madura foot: a systematic review. ( 29995713 )
2018
15
Madura foot: a case report. ( 30374377 )
2018
16
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. ( 28192433 )
2017
17
Mycetoma laboratory diagnosis: Review article. ( 28837657 )
2017
18
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
19
Mycetoma in a non-endemic area: a diagnostic challenge. ( 28167862 )
2017
20
Unusual Presentation of Mycetoma of the Foot: A Rare Case Report. ( 28630831 )
2017
21
Post-tuberculosis mycetoma: bronchoscopic removal. ( 28580148 )
2017
22
Images in COPD: Bullous Emphysema with Mycetoma. ( 28848927 )
2017
23
Scedosporium apiospermum Mycetoma in an Immunocompetent Patient without Prior Lung Disease. ( 28035880 )
2017
24
Mycetoma: An Update. ( 28794542 )
2017
25
Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature. ( 28410611 )
2017
26
Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16-year-old Fjord pony gelding with pituitary pars intermedia dysfunction. ( 28736852 )
2017
27
Mycetoma (Madura Foot) in Israel: Recent Cases and a Systematic Review of the Literature. ( 28719270 )
2017
28
Rapid and Robust Identification of the Agents of Black-Grain Mycetoma by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. ( 28592546 )
2017
29
Closing the mycetoma knowledge gap. ( 28992217 )
2017
30
Metastatic Cancer Mimicking a Mycetoma. ( 28207281 )
2017
31
Persistent Hemoptysis in an Elderly Patient with Pseudoallescheria boydii Mycetoma. ( 28336056 )
2017
32
Mycetoma: A global medical and socio-economic dilemma. ( 28426654 )
2017
33
Molecular identification of unusual Mycetoma agents isolated from patients in Venezuela. ( 27766680 )
2017
34
Aspergillus Mycetoma Causing Epiphora and Ipsilateral Facial Pain. ( 27046035 )
2017
35
Madura foot caused by Gordonia terrae misdiagnosed as Nocardia. ( 27270783 )
2017
36
Dot-in-Circle Sign - A Diagnostic MRI Sign for "Madura Foot". ( 28302229 )
2017
37
Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease. ( 27022493 )
2016
38
Mycetoma: a unique neglected tropical disease. ( 26738840 )
2016
39
Genome Sequence of Madurella mycetomatis mm55, Isolated from a Human Mycetoma Case in Sudan. ( 27231361 )
2016
40
Predictors of Post-operative Mycetoma Recurrence Using Machine-Learning Algorithms: The Mycetoma Research Center Experience. ( 27798643 )
2016
41
Role of a NSAID in the apparent cure of a fungal mycetoma. ( 27233662 )
2016
42
The Surgical Treatment of Mycetoma. ( 27336736 )
2016
43
A case of Aspergillus nidulans causing white granule mycetoma. ( 26900232 )
2016
44
Hand Mycetoma: The Mycetoma Research Centre Experience and Literature Review. ( 27483367 )
2016
45
Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication. ( 27442512 )
2016
46
Mycetoma Pulmonary Secondaries from a Gluteal Eumycetoma: An Unusual Presentation. ( 27711109 )
2016
47
Mycetoma. ( 27559532 )
2016
48
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. ( 26882058 )
2016
49
Starting from scratch-the unique neglect of mycetoma. ( 27684346 )
2016
50
Mycetoma: A Long Journey from Neglect. ( 26797103 )
2016
Sources

Variations for Mycetoma

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Expression for Mycetoma

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Search GEO for disease gene expression data for Mycetoma.
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Pathways for Mycetoma

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Pathways related to Mycetoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Insulin receptor recycling 66
Show member pathways
 12.28 CCL5 CXCL8 CXCR2 NOS2
2
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 12.14 CCL5 CXCL8 CXCR2 NOS2
3
Spinal Cord Injury 1
11.83 CXCL8 MMP9 NOS2
4
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.8 CCL5 CXCL8 CXCR2
5
Interleukin-4 and 13 signaling 66
11.73 CXCL8 IL10 MMP9 NOS2
6
Amoebiasis 37
11.71 CXCL8 IL10 NOS2
7
Metabolism of steroid hormones 66
Show member pathways
 11.64 CYP17A1 CYP19A1 HSD3B1
8
Pertussis 37
11.57 CXCL8 IL10 NOS2
9
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.47 CCL5 IL10 MMP9 NOS2
10
Lung fibrosis 1
11.45 CCL5 CXCL8 MMP9
11
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.43 CXCL8 MMP9 NOS2
12
Interleukin-10 signaling 66
11.3 CCL5 CXCL8 IL10
13
Androstenedione and testosterone biosynthesis and metabolism p.1 22
Show member pathways
 11.29 COMT CYP17A1 CYP19A1 HSD3B1
14
Malaria 37
11.15 CR1 CXCL8 IL10 THBS4
15
Estrogen metabolism 1
Show member pathways
 11.11 COMT CYP19A1 CYP1B1
16
EBV LMP1 signaling 1
10.96 CCL5 CXCL8
17
Ovarian steroidogenesis 37
10.95 CYP17A1 CYP19A1 CYP1B1 HSD3B1
18
Steroid hormone biosynthesis 37
Show member pathways
 10.84 COMT CYP17A1 CYP19A1 CYP1B1 HSD3B1
19
Syndecan-1-mediated signaling events 1
10.8 CCL5 MMP9
Sources

GO Terms for Mycetoma

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Cellular components related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CCL5 CHIT1 CSN1S1 CXCL8 IL10 MMP9

Biological processes related to Mycetoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.97 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 inflammatory response GO:0006954 9.88 CCL5 CXCL8 CXCR2 IL10
3 immune response GO:0006955 9.8 CCL5 CHIT1 CXCL8 CXCR2 IL10
4 positive regulation of angiogenesis GO:0045766 9.77 CXCL8 CXCR2 CYP1B1
5 neutrophil chemotaxis GO:0030593 9.67 CCL5 CXCL8 CXCR2
6 cytokine-mediated signaling pathway GO:0019221 9.65 CCL5 CXCL8 IL10 MMP9 NOS2
7 chemokine-mediated signaling pathway GO:0070098 9.61 CCL5 CXCL8 CXCR2
8 leukocyte chemotaxis GO:0030595 9.6 CXCL8 IL10
9 dendritic cell chemotaxis GO:0002407 9.57 CCL5 CXCR2
10 estrogen biosynthetic process GO:0006703 9.56 CYP19A1 HSD3B1
11 estrogen metabolic process GO:0008210 9.55 COMT CYP1B1
12 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.54 CCL5 CXCL8
13 steroid biosynthetic process GO:0006694 9.54 CYP17A1 CYP19A1 HSD3B1
14 nitric oxide biosynthetic process GO:0006809 9.52 CYP1B1 NOS2
15 response to molecule of bacterial origin GO:0002237 9.51 CXCL8 IL10
16 androgen biosynthetic process GO:0006702 9.48 CYP17A1 HSD3B1
17 glucocorticoid biosynthetic process GO:0006704 9.46 CYP17A1 HSD3B1
18 sterol metabolic process GO:0016125 9.33 CYP17A1 CYP19A1 CYP1B1
19 endothelial cell-cell adhesion GO:0071603 9.32 CYP1B1 THBS4
20 positive regulation of neutrophil chemotaxis GO:0090023 9.13 CXCL8 CXCR2 THBS4
21 neutrophil activation GO:0042119 8.8 CCL5 CXCL8 CXCR2

Molecular functions related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.65 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 iron ion binding GO:0005506 9.5 CYP17A1 CYP19A1 CYP1B1
3 aromatase activity GO:0070330 9.37 CYP19A1 CYP1B1
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP17A1 CYP19A1 CYP1B1
5 heme binding GO:0020037 9.26 CYP17A1 CYP19A1 CYP1B1 NOS2
6 oxygen binding GO:0019825 8.8 CYP17A1 CYP19A1 CYP1B1
Sources

Sources for Mycetoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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