MCID: MYC012
MIFTS: 47

Mycetoma

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Mycetoma

MalaCards integrated aliases for Mycetoma:

Name: Mycetoma 53 59 73
Madura Foot 53 59
Mycetoma of Foot 73

Characteristics:

Orphanet epidemiological data:

59
mycetoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA2583
MESH via Orphanet 45 D008271
UMLS via Orphanet 74 C0024449
ICD10 via Orphanet 34 B47.0 B47.1 B47.9
ICD10 33 B47 B47.9
UMLS 73 C2355609

Summaries for Mycetoma

NIH Rare Diseases : 53 Mycetoma is a chronic infection that is caused by fungi or actinomycetes (bacteria that produce filaments, like fungi). The first symptom of the condition is generally painless swelling beneath the skin, which progresses to a nodule (lump) over several years. Eventually, affected people experience massive swelling and hardening of the affected area; skin rupture; and formation of sinus tracts (holes) that discharge pus and grains filled with organisms. Some affected people have no discomfort while others report itching and/or pain. Mycetoma is rare in the United States, but is commonly diagnosed in Africa, Mexico and India. In these countries, it occurs most frequently in farmers, shepherds, and people living in rural areas. Frequent exposure to penetrating wounds by thorns or splinters is a risk factor. Treatment varies based on the cause of the condition and may include antibiotics or antifungal medications.

MalaCards based summary : Mycetoma, also known as madura foot, is related to eumycotic mycetoma and pneumonia. An important gene associated with Mycetoma is CHIT1 (Chitinase 1), and among its related pathways/superpathways are Insulin receptor recycling and Immune response CCR3 signaling in eosinophils. The drugs Miconazole and Itraconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotype is renal/urinary system.

Wikipedia : 76 Mycetoma is a term for a chronic subcutaneous infection caused by aerobic actinomycetic bacteria... more...

Related Diseases for Mycetoma

Diseases related to Mycetoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 eumycotic mycetoma 33.2 CCL5 CR1 TPT1
2 pneumonia 29.3 CCL5 CXCL8 IL10
3 lung disease 29.1 CCL5 CXCL8 IL10 MMP9
4 actinomycosis 11.5
5 hemorrhoid 10.7 MMP9 NOS2
6 internal hemorrhoid 10.6 MMP9 NOS2
7 ross river fever 10.6 COMT IL10
8 idiopathic achalasia 10.5 IL10 NOS2
9 filariasis 10.5 CCL5 CHIT1 IL10
10 back pain 10.5 COMT MMP9
11 tropical spastic paraparesis 10.5 CCL5 IL10 MMP9
12 relapsing-remitting multiple sclerosis 10.4 CCL5 IL10 MMP9
13 demyelinating disease 10.4 CCL5 IL10 MMP9
14 vibratory urticaria 10.3 CXCL8 MMP9
15 testicular leydig cell tumor 10.3 CYP17A1 HSD3B1
16 tungiasis 10.3 CXCL8 IL10
17 pouchitis 10.2 CXCL8 IL10
18 scabies 10.2 CXCL8 IL10
19 neurosyphilis 10.2 CXCL8 IL10
20 necatoriasis 10.2 CXCL8 IL10
21 transsexualism 10.2 CYP17A1 CYP19A1
22 allergic hypersensitivity disease 10.1 CSN1S1 IL10 TPT1
23 funisitis 10.1 CXCL8 IL10
24 cryptogenic organizing pneumonia 10.1 CXCL8 MMP9
25 corneal ulcer 10.1 CYP1B1 MMP9
26 vulvovaginitis 10.1 CCL5 CXCL8 IL10
27 trichuriasis 10.1 CXCL8 IL10
28 radiculopathy 10.1 CCL5 CXCL8 IL10
29 cytomegalovirus infection 10.1 CCL5 CXCL8 IL10
30 periapical granuloma 10.1 CCL5 CXCL8
31 viral encephalitis 10.1 CCL5 CXCL8 IL10
32 extrinsic allergic alveolitis 10.1 CCL5 CXCL8 IL10
33 acute transverse myelitis 10.1 CXCL8 IL10 MMP9
34 transverse myelitis 10.0 CXCL8 IL10 MMP9
35 bronchial disease 10.0 CCL5 CXCL8 IL10
36 steroid inherited metabolic disorder 10.0 CYP17A1 HSD3B1
37 helicobacter pylori infection 10.0 CCL5 CXCL8 IL10
38 clonorchiasis 10.0 CXCL8 IL10
39 bronchiolitis 10.0 CCL5 CXCL8 IL10
40 appendicitis 10.0 CXCL8 IL10 MMP9
41 trypanosomiasis 10.0 CCL5 CXCL8 IL10
42 chlamydia 10.0 CXCL8 IL10 NOS2
43 bronchiolitis obliterans 10.0 CXCL8 IL10 MMP9
44 bacterial meningitis 10.0 CXCL8 IL10 MMP9
45 allergic asthma 10.0 CCL5 CXCL8 IL10
46 chagas disease 10.0 CXCL8 IL10 NOS2
47 crohn's colitis 10.0 CXCL8 NOS2
48 meningitis 10.0 CXCL8 IL10 MMP9
49 periodontitis 9.9 CXCL8 IL10 MMP9
50 lipoid congenital adrenal hyperplasia 9.9 CYP17A1 CYP19A1 HSD3B1

Graphical network of the top 20 diseases related to Mycetoma:



Diseases related to Mycetoma

Symptoms & Phenotypes for Mycetoma

MGI Mouse Phenotypes related to Mycetoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 COMT CXCR2 CYP17A1 CYP19A1 MMP9 NOS2

Drugs & Therapeutics for Mycetoma

Drugs for Mycetoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
2
Itraconazole Approved, Investigational Phase 4,Phase 2 84625-61-6 55283
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Hydroxyitraconazole Phase 4,Phase 2
5 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
6 Steroid Synthesis Inhibitors Phase 4,Phase 2
7 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
9 Hormone Antagonists Phase 4,Phase 2
10 Hormones Phase 4,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
12 Anti-Infective Agents Phase 4,Phase 2
13 Antifungal Agents Phase 4,Phase 2
14 Antitussive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
2 Proof-of-Concept Superiority Trial of Fosravuconazole Versus Itraconazole for Eumycetoma in Sudan Recruiting NCT03086226 Phase 2 Fosravuconazole;Itraconazole

Search NIH Clinical Center for Mycetoma

Genetic Tests for Mycetoma

Anatomical Context for Mycetoma

MalaCards organs/tissues related to Mycetoma:

41
Skin, Lung, Bone, Kidney, Heart, Prostate, Pituitary

Publications for Mycetoma

Articles related to Mycetoma:

(show top 50) (show all 576)
# Title Authors Year
1
Chronic Madura foot: mycetoma and/or <i>Actinomyces</i> spp or actinomycosis. ( 29789306 )
2018
2
A holistic approach to the mycetoma management. ( 29746460 )
2018
3
Cutaneous tuberculosis mimicking a mycetoma. ( 29882520 )
2018
4
Mycetoma: reviewing a neglected disease. ( 29808607 )
2018
5
Mycetoma in the Togolese: An Update from a Single-Center Experience. ( 29557534 )
2018
6
Case 249: Intramuscular Mycetoma. ( 29261466 )
2018
7
Staphylococcal infection of lower leg mimicking mycetoma. ( 29869404 )
2018
8
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. ( 28192433 )
2017
9
Mycetoma laboratory diagnosis: Review article. ( 28837657 )
2017
10
Mycetoma-like chromoblastomycosis: a diagnostic dilemma. ( 28233299 )
2017
11
Mycetoma in a non-endemic area: a diagnostic challenge. ( 28167862 )
2017
12
Unusual Presentation of Mycetoma of the Foot: A Rare Case Report. ( 28630831 )
2017
13
Post-tuberculosis mycetoma: bronchoscopic removal. ( 28580148 )
2017
14
Images in COPD: Bullous Emphysema with Mycetoma. ( 28848927 )
2017
15
Scedosporium apiospermum Mycetoma in an Immunocompetent Patient without Prior Lung Disease. ( 28035880 )
2017
16
Mycetoma: An Update. ( 28794542 )
2017
17
Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature. ( 28410611 )
2017
18
Successful medical treatment of an Aspergillus terreus mycetoma of the nostril/lip in a 16-year-old Fjord pony gelding with pituitary pars intermedia dysfunction. ( 28736852 )
2017
19
Mycetoma (Madura Foot) in Israel: Recent Cases and a Systematic Review of the Literature. ( 28719270 )
2017
20
Rapid and Robust Identification of the Agents of Black-Grain Mycetoma by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. ( 28592546 )
2017
21
Closing the mycetoma knowledge gap. ( 28992217 )
2017
22
Metastatic Cancer Mimicking a Mycetoma. ( 28207281 )
2017
23
Persistent Hemoptysis in an Elderly Patient with Pseudoallescheria boydii Mycetoma. ( 28336056 )
2017
24
Mycetoma: A global medical and socio-economic dilemma. ( 28426654 )
2017
25
Molecular identification of unusual Mycetoma agents isolated from patients in Venezuela. ( 27766680 )
2017
26
Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease. ( 27022493 )
2016
27
Mycetoma: a unique neglected tropical disease. ( 26738840 )
2016
28
Genome Sequence of Madurella mycetomatis mm55, Isolated from a Human Mycetoma Case in Sudan. ( 27231361 )
2016
29
Predictors of Post-operative Mycetoma Recurrence Using Machine-Learning Algorithms: The Mycetoma Research Center Experience. ( 27798643 )
2016
30
Role of a NSAID in the apparent cure of a fungal mycetoma. ( 27233662 )
2016
31
The Surgical Treatment of Mycetoma. ( 27336736 )
2016
32
A case of Aspergillus nidulans causing white granule mycetoma. ( 26900232 )
2016
33
Hand Mycetoma: The Mycetoma Research Centre Experience and Literature Review. ( 27483367 )
2016
34
Multiple Mycetoma Lung Secondaries from Knee Eumycetoma: An Unusual Complication. ( 27442512 )
2016
35
Mycetoma Pulmonary Secondaries from a Gluteal Eumycetoma: An Unusual Presentation. ( 27711109 )
2016
36
Mycetoma. ( 27559532 )
2016
37
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma. ( 26882058 )
2016
38
Starting from scratch-the unique neglect of mycetoma. ( 27684346 )
2016
39
Mycetoma: A Long Journey from Neglect. ( 26797103 )
2016
40
Aspergillus Mycetoma Causing Epiphora and Ipsilateral Facial Pain. ( 27046035 )
2016
41
Gunpowder or Mycetoma? ( 25911568 )
2015
42
Paradoxical response preceding control of Scedosporium apiospermum mycetoma with posaconazole treatment. ( 26114987 )
2015
43
A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study. ( 26332238 )
2015
44
A rare case of mycetoma due to curvularia. ( 25949061 )
2015
45
Mycetoma: an old and still neglected tropical disease. ( 25667234 )
2015
46
Revisiting antiseptic use in reducing post-surgical recurrence in mycetoma. ( 26036161 )
2015
47
Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan. ( 25816316 )
2015
48
Mycetoma of the foot--diagnosis of the etiologic agent and surgical treatment. ( 26157078 )
2015
49
Head and neck mycetoma: the mycetoma research centre experience. ( 25768090 )
2015
50
Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog. ( 26017318 )
2015

Variations for Mycetoma

Expression for Mycetoma

Search GEO for disease gene expression data for Mycetoma.

Pathways for Mycetoma

Pathways related to Mycetoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 CCL5 CXCL8 CXCR2 NOS2
2
Show member pathways
12.12 CCL5 CXCL8 CXCR2 NOS2
3 11.82 CXCL8 MMP9 NOS2
4
Show member pathways
11.79 CCL5 CXCL8 CXCR2
5 11.69 CXCL8 IL10 NOS2
6 11.68 CXCL8 IL10 MMP9 NOS2
7
Show member pathways
11.63 CYP17A1 CYP19A1 HSD3B1
8 11.55 CXCL8 IL10 NOS2
9 11.43 CCL5 CXCL8 MMP9
10
Show member pathways
11.41 CXCL8 MMP9 NOS2
11
Show member pathways
11.29 COMT CYP17A1 CYP19A1 HSD3B1
12 11.27 CCL5 CXCL8 IL10
13 11.15 CR1 CXCL8 IL10 THBS4
14
Show member pathways
11.08 COMT CYP19A1 CYP1B1
15 10.96 CCL5 CXCL8
16 10.95 CYP17A1 CYP19A1 CYP1B1 HSD3B1
17
Show member pathways
10.83 COMT CYP17A1 CYP19A1 CYP1B1 HSD3B1
18 10.79 CCL5 MMP9

GO Terms for Mycetoma

Cellular components related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CCL5 CHIT1 CSN1S1 CXCL8 IL10 MMP9

Biological processes related to Mycetoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.98 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 positive regulation of angiogenesis GO:0045766 9.78 CXCL8 CXCR2 CYP1B1
3 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 IL10 NOS2
4 inflammatory response GO:0006954 9.77 CCL5 CXCL8 CXCR2 IL10 NOS2
5 response to lipopolysaccharide GO:0032496 9.71 COMT CXCL8 IL10 NOS2
6 chemokine-mediated signaling pathway GO:0070098 9.65 CCL5 CXCL8 CXCR2
7 cytokine-mediated signaling pathway GO:0019221 9.65 CCL5 CXCL8 IL10 MMP9 NOS2
8 neutrophil chemotaxis GO:0030593 9.63 CCL5 CXCL8 CXCR2
9 positive regulation of JAK-STAT cascade GO:0046427 9.61 CCL5 CYP1B1
10 steroid biosynthetic process GO:0006694 9.61 CYP17A1 CYP19A1 HSD3B1
11 positive regulation of leukocyte chemotaxis GO:0002690 9.6 CXCL8 CXCR2
12 dendritic cell chemotaxis GO:0002407 9.58 CCL5 CXCR2
13 nitric oxide biosynthetic process GO:0006809 9.57 CYP1B1 NOS2
14 estrogen metabolic process GO:0008210 9.56 COMT CYP1B1
15 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 IL10
16 estrogen biosynthetic process GO:0006703 9.54 CYP19A1 HSD3B1
17 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.52 CCL5 CXCL8
18 androgen biosynthetic process GO:0006702 9.51 CYP17A1 HSD3B1
19 glucocorticoid biosynthetic process GO:0006704 9.49 CYP17A1 HSD3B1
20 positive regulation of neutrophil chemotaxis GO:0090023 9.33 CXCL8 CXCR2 THBS4
21 endothelial cell-cell adhesion GO:0071603 9.32 CYP1B1 THBS4
22 sterol metabolic process GO:0016125 9.13 CYP17A1 CYP19A1 CYP1B1
23 neutrophil activation GO:0042119 8.8 CCL5 CXCL8 CXCR2

Molecular functions related to Mycetoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.72 CYP17A1 CYP19A1 CYP1B1 HSD3B1 NOS2
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP17A1 CYP19A1 CYP1B1
3 aromatase activity GO:0070330 9.37 CYP19A1 CYP1B1
4 oxygen binding GO:0019825 9.33 CYP17A1 CYP19A1 CYP1B1
5 iron ion binding GO:0005506 9.26 CYP17A1 CYP19A1 CYP1B1 NOS2
6 heme binding GO:0020037 8.92 CYP17A1 CYP19A1 CYP1B1 NOS2

Sources for Mycetoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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