MCID: MYC013
MIFTS: 45

Mycobacterium Abscessus

Categories: Rare diseases

Aliases & Classifications for Mycobacterium Abscessus

MalaCards integrated aliases for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 53
Mycobacterium Abscessus Infection 53
M. Abscessus 53

Classifications:



Summaries for Mycobacterium Abscessus

MalaCards based summary : Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to mycobacterium chelonae and mycobacterium kansasii. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Azithromycin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Mycobacterium abscessus complex (MABSC) is a group of rapidly growing, multidrug-resistant... more...

Related Diseases for Mycobacterium Abscessus

Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 mycobacterium chelonae 31.6 CXCL8 TLR2
2 mycobacterium kansasii 30.4 CXCL8 NLRP3 TLR2
3 nontuberculous mycobacterial lung disease 30.1 CFTR TLR2 TNF
4 otitis media 30.0 CXCL8 TLR2 TNF
5 endocarditis 30.0 CXCL8 TLR2 TNF
6 pneumonia 29.9 CXCL8 TLR2 TNF
7 peritonitis 29.9 CXCL8 TLR2 TNF
8 meningitis 29.2 CXCL8 NLRP3 TLR2 TNF
9 bronchiolitis 29.2 CXCL8 TLR1 TNF
10 bronchiectasis 29.0 CFTR CXCL8 SERPINA1 TLR2
11 lung disease 28.5 CFTR CXCL8 SERPINA1 TLR2 TNF
12 respiratory failure 28.3 CXCL8 SERPINA1 TNF
13 macs syndrome 11.2
14 cystic fibrosis 10.6
15 subcutaneous mycosis 10.6 CLEC7A SYK
16 aspergillosis 10.4 CFTR CLEC7A TLR2
17 trench fever 10.3 TLR2 TNF
18 common wart 10.3 CLEC7A CXCL8
19 vulvar vestibulitis syndrome 10.3 NLRP3 TNF
20 autoimmune pancreatitis 10.3 CFTR TNF
21 mycobacterium fortuitum 10.3
22 osteomyelitis 10.2
23 periodic fever, familial, autosomal dominant 10.2 NLRP3 TNF
24 sebaceous gland disease 10.2 CXCL8 TLR2
25 vulvovaginal candidiasis 10.2 CLEC7A NLRP3
26 nonalcoholic steatohepatitis 10.2 SQSTM1 TNF
27 neurosyphilis 10.2 CXCL8 TLR1 TLR2
28 endophthalmitis 10.2
29 mastitis 10.1
30 lymphadenitis 10.1
31 penicilliosis 10.1 TLR1 TLR2 TNF
32 arthritis 10.1
33 q fever 10.0 TLR1 TLR2 TNF
34 tungiasis 10.0 CXCL8 TNF
35 melioidosis 10.0 TLR1 TLR2 TNF
36 filariasis 10.0 TLR1 TLR2 TNF
37 lyme disease 10.0 TLR1 TLR2 TNF
38 streptococcal toxic-shock syndrome 10.0 CXCL8 TNF
39 primary systemic mycosis 10.0 CLEC7A TLR2 TNF
40 alveolar echinococcosis 10.0 TLR2 TNF
41 cervical adenitis 10.0
42 keratopathy 10.0
43 scleritis 10.0
44 prostatitis 10.0
45 rheumatoid arthritis 10.0
46 cervicitis 10.0
47 trichuriasis 10.0 CXCL8 TNF
48 clonorchiasis 10.0 CXCL8 TNF
49 crohn's colitis 9.9 CXCL8 TNF
50 arthus reaction 9.9 HMOX1 TNF

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to Mycobacterium Abscessus

Symptoms & Phenotypes for Mycobacterium Abscessus

MGI Mouse Phenotypes related to Mycobacterium Abscessus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 HMOX1 TNF IFNGR2 NLRP3 SQSTM1 SYK
2 homeostasis/metabolism MP:0005376 9.96 TLR2 HMOX1 TNF IFNGR2 MSRA NLRP3
3 immune system MP:0005387 9.85 HMOX1 TNF IFNGR2 NLRP3 SQSTM1 SYK
4 liver/biliary system MP:0005370 9.5 HMOX1 TNF NLRP3 SQSTM1 SYK CFTR
5 respiratory system MP:0005388 9.1 CLEC7A TLR2 HMOX1 TNF SYK CFTR

Drugs & Therapeutics for Mycobacterium Abscessus

Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Minocycline Approved, Investigational Phase 2 10118-90-8 5281021
3
Tigecycline Approved Phase 2 220620-09-7 5282044
4
Nitric Oxide Approved Phase 2 10102-43-9 145068 160954
5
Amikacin Approved, Investigational, Vet_approved Phase 2 37517-28-5 37768
6 Anti-Bacterial Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Respiratory System Agents Phase 2
9 Neurotransmitter Agents Phase 2
10 Vasodilator Agents Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Endothelium-Dependent Relaxing Factors Phase 2
13 Peripheral Nervous System Agents Phase 2
14 Antioxidants Phase 2
15 Protective Agents Phase 2
16 Autonomic Agents Phase 2
17 Bronchodilator Agents Phase 2
18 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Azithromycin in the Treatment of M. Avium Complex Lung Disease Completed NCT00599079 Phase 4 Azithromycin
2 Tigecycline for Treatment of Rapidly Growing Mycobacteria Completed NCT00600600 Phase 2 Tigecycline
3 Inhaled Nitric Oxide for Patients With MABSC Recruiting NCT03208764 Phase 2 Nitric Oxide
4 Liposomal Amikacin for Inhalation (LAI) in the Treatment of Mycobacterium Abscessus Lung Disease Active, not recruiting NCT03038178 Phase 2 LAI plus multi-drug regimen
5 Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
6 The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease Unknown status NCT02005094
7 The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and Bronchiolitis Unknown status NCT01354912
8 Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease Recruiting NCT02832843
9 The Italian REgistry of Pulmonary Non-tuberculous mycobactEria Recruiting NCT03339063

Search NIH Clinical Center for Mycobacterium Abscessus

Genetic Tests for Mycobacterium Abscessus

Anatomical Context for Mycobacterium Abscessus

MalaCards organs/tissues related to Mycobacterium Abscessus:

41
Lung, Skin, Testes, Colon, T Cells, Prostate, Neutrophil

Publications for Mycobacterium Abscessus

Articles related to Mycobacterium Abscessus:

(show top 50) (show all 504)
# Title Authors Year
1
Mycobacterium abscessus Infections in Children: A Review of Current Literature. ( 29897511 )
2018
2
Determination of MIC Distribution and Mechanisms of Decreased Susceptibility to Bedaquiline among Clinical Isolates of Mycobacterium abscessus. ( 29712658 )
2018
3
Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus. ( 29913527 )
2018
4
Mycobacterium abscessus Left Ventricle Assist Device Driveline Infections: An Emerging Pathogen? ( 29896814 )
2018
5
<i>Mycobacterium abscessus</i> complex: Natural history and treatment outcomes at a tertiary adult cystic fibrosis center. ( 29900884 )
2018
6
<i>Mycobacterium abscessus</i> subsp. <i>massiliense mycma_0076</i> and <i>mycma_0077</i> Genes Code for Ferritins That Are Modulated by Iron Concentration. ( 29910777 )
2018
7
<i>Mycobacterium abscessus</i> Complex Infections: A Retrospective Cohort Study. ( 29450214 )
2018
8
Clinical aspects in patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex, in the Brazilian Amazon. ( 29791556 )
2018
9
<i>Mycobacterium abscessus</i> Smooth And Rough Morpohotypes Form Antimicrobial-Tolerant Biofilm Phenotypes But Are Killed by Acetic Acid. ( 29311080 )
2018
10
Glycopeptidolipids, a Double-Edged Sword of the <i>Mycobacterium abscessus</i> Complex. ( 29922253 )
2018
11
Complete Genome Sequence of a Type Strain of<i>Mycobacterium abscessus</i>subsp.<i>bolletii</i>, a Member of the<i>Mycobacterium abscessus</i>Complex. ( 29437099 )
2018
12
Rifabutin acts in synergy and is bactericidal with frontline <i>Mycobacterium abscessus</i> antibiotics clarithromycin and tigecycline, suggesting a potent treatment combination. ( 29760147 )
2018
13
Antimicrobial effect of dimethyl sulfoxide and <i>N, N</i>-Dimethylformamide on <i>Mycobacterium abscessus</i>: Implications for antimicrobial susceptibility testing. ( 29900888 )
2018
14
A Successful Aggressive Surgical and Medical approach to Pulmonary Artery Obstruction due to Mycobacterium abscessus Infection post Lung Transplantation. ( 29359876 )
2018
15
<i>In vitro</i> and intracellular activity of imipenem combined to rifabutin and avibactam against <i>Mycobacterium abscessus</i>. ( 29866869 )
2018
16
Identification of genes required for<i>Mycobacterium abscessus</i>growth in vivo with a prominent role of the ESX-4 locus. ( 29343644 )
2018
17
Association between sequevar and antibiotic treatment outcome in patients with Mycobacterium abscessus complex infections in Japan. ( 29227218 )
2018
18
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice. ( 29421865 )
2018
19
Cutaneous infection with Mycobacterium abscessus. ( 29974168 )
2018
20
Mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. ( 28988958 )
2018
21
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for rapid identification of<i>Mycobacterium abscessus</i>. ( 29386727 )
2018
22
Disseminated <i>Mycobacterium abscessus</i> infection with spondylodiscitis of thoracic spine. ( 29942485 )
2018
23
Teicoplanin - Tigecycline Combination Shows Synergy Against <i>Mycobacterium abscessus</i>. ( 29867841 )
2018
24
Pathogen Box screening for hit identification against Mycobacterium abscessus. ( 29698397 )
2018
25
Pulmonary alveolar proteinosis and <i>Mycobacterium abscessus</i> lung infection related to ruxolitinib after allogeneic stem cell transplantation. ( 29650554 )
2018
26
Inhaled Granulocyte-Macrophage Colony Stimulating Factor for<b> <i>Mycobacterium Abscessus</i> </b>in Cystic Fibrosis. ( 29419443 )
2018
27
Mycobacterium abscessus infections in lung transplant recipients: 15-year experience from a single institution. ( 29359872 )
2018
28
Chronic Otitis Media Caused by Mycobacterium abscessus spp. massiliense Treated by Tigecycline in a 10 year-old-child. ( 29966711 )
2018
29
In vitro activity of tedizolid against the Mycobacterium abscessus complex. ( 29217419 )
2018
30
Anomalies in T Cell Function Are Associated With Individuals at Risk of <i>Mycobacterium abscessus</i> Complex Infection. ( 29942313 )
2018
31
First United States Outbreak of Mycobacterium abscessus Hand and Foot Disease Among Children Associated With a Wading Pool. ( 29850835 )
2018
32
Mutations in <i>gyrA</i> and <i>gyrB</i> in Moxifloxacin-Resistant <i>Mycobacterium avium</i> Complex and <i>Mycobacterium abscessus</i> Complex Clinical Isolates. ( 29914959 )
2018
33
Establishment and validation of<i>Galleria mellonella</i>as a novel model organism to study<i>Mycobacterium abscessus</i>infection, pathogenesis and treatment. ( 29437630 )
2018
34
Novel Mutations Associated with Clofazimine Resistance in Mycobacterium abscessus. ( 29712660 )
2018
35
Pediatric Dental Clinic-Associated Outbreak of Mycobacterium abscessus Infection. ( 28903524 )
2017
36
Multidrug-resistant Mycobacterium abscessus threatens patients with cystic fibrosis. ( 27956215 )
2017
37
Bedaquiline inhibits the ATP synthase in Mycobacterium abscessus and is effective in infected zebrafish. ( 28807917 )
2017
38
Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease. ( 29329759 )
2017
39
Multi-Drug Resistant Surgical Site Infection Due to Mycobacterium abscessus Complex. ( 28934511 )
2017
40
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
41
Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation. ( 28077517 )
2017
42
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. ( 28903728 )
2017
43
Mycobacterium abscessus glossitis. ( 28948933 )
2017
44
Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. ( 29059250 )
2017
45
<i>Mycobacterium abscessus</i> disease in lung transplant recipients: Diagnosis and management. ( 29276785 )
2017
46
Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. ( 28874233 )
2017
47
Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients. ( 28495380 )
2017
48
Mycobacterium abscessus glycopeptidolipids inhibit macrophage apoptosis and bacterial spreading by targeting mitochondrial cyclophilin D. ( 28837151 )
2017
49
Anti-interferon-I^ autoantibody-associated disseminated Mycobacterium abscessus infection mimicking parotid cancer with multiple metastases: A case report. ( 28953638 )
2017
50
Granulomatous Lobular Mastitis Associated with Mycobacterium abscessus in South China: A Case Report and Review of the Literature. ( 28286681 )
2017

Variations for Mycobacterium Abscessus

Expression for Mycobacterium Abscessus

Search GEO for disease gene expression data for Mycobacterium Abscessus.

Pathways for Mycobacterium Abscessus

Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CLEC7A CXCL8 HMOX1 IFNGR2 NLRP3 SERPINA1
2
Show member pathways
13.22 CXCL8 HMOX1 IFNGR2 SQSTM1 SYK TNF
3
Show member pathways
12.67 IFNGR2 SYK TLR1 TLR2 TNF
4
Show member pathways
12.66 CXCL8 IFNGR2 NLRP3 TLR2 TNF
5
Show member pathways
12.61 CXCL8 IFNGR2 NLRP3 SQSTM1 SYK TLR1
6
Show member pathways
12.45 CXCL8 SYK TLR2 TNF
7 12.39 HMOX1 SYK TLR1 TLR2 TNF
8
Show member pathways
12.37 TLR1 TLR2 TNF
9
Show member pathways
12.22 CFTR CXCL8 TLR2 TNF
10
Show member pathways
12.13 CXCL8 IFNGR2 TNF
11
Show member pathways
12.13 IFNGR2 TLR1 TLR2 TNF
12
Show member pathways
12.08 CLEC7A NLRP3 SYK TNF
13
Show member pathways
12.06 IFNGR2 NLRP3 SQSTM1 TNF
14
Show member pathways
12.04 CXCL8 SQSTM1 TLR1 TLR2 TNF
15 12.03 IFNGR2 TLR1 TLR2 TNF
16 11.98 HMOX1 SERPINA1 SQSTM1
17 11.96 HMOX1 SQSTM1 TNF
18 11.9 IFNGR2 SQSTM1 SYK TNF
19
Show member pathways
11.9 CFTR CXCL8 HMOX1 TLR2 TNF
20 11.87 CXCL8 HMOX1 TNF
21 11.78 CXCL8 TLR2 TNF
22 11.77 CXCL8 SYK TNF
23 11.74 CXCL8 TLR2 TNF
24 11.71 CLEC7A TLR1 TLR2
25 11.69 CLEC7A IFNGR2 SYK TLR1 TLR2 TNF
26 11.66 CXCL8 NLRP3 TNF
27 11.48 CXCL8 TLR2 TNF
28 11.42 CXCL8 HMOX1 SERPINA1 TNF
29 11.41 CXCL8 TLR2 TNF
30
Show member pathways
11.32 CFTR CXCL8 IFNGR2 TLR1 TLR2 TNF
31 11.03 CXCL8 TNF
32 11.03 NLRP3 TLR1 TLR2
33 10.89 CXCL8 HMOX1 TNF

GO Terms for Mycobacterium Abscessus

Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.43 CFTR HMOX1 IFNGR2 NLRP3 SERPINA1 SQSTM1
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL8 TLR1 TLR2 TNF
2 innate immune response GO:0045087 9.89 CLEC7A NLRP3 SYK TLR1 TLR2
3 intracellular signal transduction GO:0035556 9.88 CXCL8 HMOX1 NLRP3 SQSTM1 SYK
4 cytokine-mediated signaling pathway GO:0019221 9.84 CXCL8 HMOX1 IFNGR2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 NLRP3 TLR2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 NLRP3 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.72 NLRP3 TLR2 TNF
8 regulation of DNA binding transcription factor activity GO:0051090 9.63 HMOX1 SYK
9 positive regulation of cytokine secretion GO:0050715 9.63 SYK TNF
10 positive regulation of interleukin-8 production GO:0032757 9.62 TLR2 TNF
11 defense response GO:0006952 9.62 CXCL8 NLRP3 TLR1 TNF
12 positive regulation of chemokine production GO:0032722 9.61 TLR2 TNF
13 embryonic digestive tract development GO:0048566 9.59 CXCL8 TNF
14 cell activation GO:0001775 9.58 TLR1 TLR2
15 negative regulation of growth of symbiont in host GO:0044130 9.58 SQSTM1 TNF
16 positive regulation of interleukin-8 secretion GO:2000484 9.57 TLR1 TLR2
17 response to molecule of bacterial origin GO:0002237 9.56 CXCL8 TLR2
18 regulation of cytokine secretion GO:0050707 9.52 TLR1 TLR2
19 positive regulation of chemokine biosynthetic process GO:0045080 9.51 HMOX1 TNF
20 cellular response to bacterial lipopeptide GO:0071221 9.46 TLR1 TLR2
21 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.43 TLR1 TLR2
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.43 NLRP3 SQSTM1 TNF
23 immune system process GO:0002376 9.43 CLEC7A NLRP3 SQSTM1 SYK TLR1 TLR2
24 cellular response to triacyl bacterial lipopeptide GO:0071727 9.4 TLR1 TLR2
25 cytokine secretion involved in immune response GO:0002374 9.37 NLRP3 TLR2
26 inflammatory response GO:0006954 9.17 CLEC7A CXCL8 NLRP3 SYK TLR1 TLR2
27 detection of triacyl bacterial lipopeptide GO:0042495 9.16 TLR1 TLR2

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.26 NLRP3 TLR2
2 lipopeptide binding GO:0071723 9.16 TLR1 TLR2
3 signaling pattern recognition receptor activity GO:0008329 8.96 CLEC7A TLR2
4 Toll-like receptor binding GO:0035325 8.62 SYK TLR2

Sources for Mycobacterium Abscessus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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