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MCID: MYC013
MIFTS: 42

Mycobacterium Abscessus

Categories: Rare diseases, Respiratory diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Mycobacterium Abscessus

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MalaCards integrated aliases for Mycobacterium Abscessus:

Name: Mycobacterium Abscessus 20
Mycobacterium Abscessus Infection 20 3
M. Abscessus 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Respiratory diseases
See all MalaCards categories (disease lists)


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Summaries for Mycobacterium Abscessus

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CDC : 3 Mycobacterium abscessus [mī–kō–bak–tair–ee–yum ab–ses–sus] (also called M. abscessus) is a bacterium distantly related to the ones that cause tuberculosis and Hansen's Disease (Leprosy). It is part of a group of environmental mycobacteria and is found in water, soil, and dust. It has been known to contaminate medications and products, including medical devices. M. abscessus can cause a variety of infections. Healthcare-associated infections due to this bacterium are usually of the skin and the soft tissues under the skin. It is also a cause of serious lung infections in persons with various chronic lung diseases, such as cystic fibrosis.

MalaCards based summary : Mycobacterium Abscessus, also known as mycobacterium abscessus infection, is related to mycobacterium chelonae and endocarditis. An important gene associated with Mycobacterium Abscessus is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Tigecycline and Amikacin have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and eye, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Mycobacterium abscessus complex (MABSC) is a group of rapidly growing, multidrug-resistant,... more...

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Related Diseases for Mycobacterium Abscessus

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Diseases related to Mycobacterium Abscessus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 mycobacterium chelonae 31.6 TLR2 CXCL8
2 endocarditis 30.8 TNF TLR2 CXCL8
3 bronchiectasis 30.7 TNF TLR2 SERPINA1 CXCL8 CFTR
4 cystic fibrosis 30.7 TNF TLR2 SERPINA1 HMOX1 CXCL8 CFTR
5 endophthalmitis 30.6 TNF TLR2 CXCL8
6 mycobacterium marinum 30.6 TLR2 CXCL8
7 otitis media 30.6 TNF TLR2 CXCL8
8 osteomyelitis 30.6 TNF TLR2 NLRP3 CXCL8
9 mycobacterium kansasii 30.6 TLR2 NLRP3 CXCL8
10 lung disease 30.6 TNF TLR2 SERPINA1 HMOX1 CXCL8 CFTR
11 peritonitis 30.5 TNF TLR2 NLRP3 CXCL8
12 keratitis, hereditary 30.4 TNF TLR2 NLRP3 CXCL8
13 nontuberculous mycobacterial lung disease 30.4 TNF TLR2 CFTR
14 septic arthritis 30.4 TNF TLR2 CXCL8
15 disease by infectious agent 30.3 TNF TLR2 SERPINA1 CFTR
16 respiratory failure 30.2 TNF SERPINA1 CXCL8 CFTR
17 bacterial pneumonia 30.2 TNF TLR2 CXCL8
18 bronchiolitis 30.2 TNF TLR2 CXCL8
19 pneumonia 30.1 TNF TLR2 SERPINA1 HMOX1 CXCL8 CFTR
20 mycobacterium tuberculosis 1 30.0 TNF TLR2 TLR1 CLEC7A
21 conjunctivitis 30.0 TNF NLRP3 CXCL8
22 pleurisy 30.0 TNF TLR2 CXCL8
23 toxic shock syndrome 29.9 TNF TLR2 CXCL8
24 neutrophilic dermatosis, acute febrile 29.9 TNF CXCL8
25 meningitis 29.9 TNF TLR2 NLRP3 CXCL8
26 exanthem 29.8 TNF SYK NLRP3 CXCL8
27 fasciitis 29.7 TNF SYK CXCL8
28 pulmonary disease, chronic obstructive 29.7 TNF TLR2 SERPINA1 HMOX1 CXCL8 CFTR
29 crohn's disease 29.6 TNF TLR2 NLRP3 CXCL8
30 liver cirrhosis 29.6 TNF TLR2 SQSTM1 SERPINA1 CXCL8
31 bacterial infectious disease 29.5 TNF TLR2 TLR1 CXCL8 CFTR
32 leprosy 3 29.4 TNF TLR2 TLR1 CXCL8
33 aspergillosis 29.2 TNF TLR2 TLR1 CXCL8 CLEC7A CFTR
34 arthritis 29.1 TNF TLR2 SYK NLRP3 CXCL8
35 immunodeficiency 28 11.2
36 fibrosis of extraocular muscles, congenital, 1 10.8
37 mycobacterium fortuitum 10.6
38 lymphadenitis 10.5
39 pulmonary tuberculosis 10.5
40 anaerobic pneumonia 10.3 TLR2 SERPINA1
41 fungal keratitis 10.3 TLR2 CLEC7A
42 acute cervicitis 10.3 TLR2 CXCL8
43 hereditary angioedema with normal c1inh 10.3 TLR2 SERPINA1
44 mastitis 10.3
45 pneumothorax 10.3
46 pleural empyema 10.3
47 cervical adenitis 10.3
48 silo filler's disease 10.2 TLR2 IFNGR2
49 immune deficiency disease 10.2
50 infective endocarditis 10.2

Graphical network of the top 20 diseases related to Mycobacterium Abscessus:



Diseases related to Mycobacterium Abscessus
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Symptoms & Phenotypes for Mycobacterium Abscessus

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MGI Mouse Phenotypes related to Mycobacterium Abscessus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CFTR CLEC7A HMOX1 IFNGR2 NLRP3 SQSTM1
2 homeostasis/metabolism MP:0005376 10.02 CFTR CLEC7A HMOX1 IFNGR2 MSRA NLRP3
3 immune system MP:0005387 9.96 CFTR CLEC7A HMOX1 IFNGR2 NLRP3 SQSTM1
4 adipose tissue MP:0005375 9.88 HMOX1 NLRP3 SQSTM1 SYK TLR2 TNF
5 liver/biliary system MP:0005370 9.7 CFTR HMOX1 NLRP3 SQSTM1 SYK TLR2
6 mortality/aging MP:0010768 9.65 CFTR CLEC7A HMOX1 MSRA NLRP3 SERPINA1
7 respiratory system MP:0005388 9.1 CFTR CLEC7A HMOX1 SYK TLR2 TNF
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Drugs & Therapeutics for Mycobacterium Abscessus

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Drugs for Mycobacterium Abscessus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tigecycline Approved Phase 2, Phase 3 220620-09-7 5282044
2
Amikacin Approved, Investigational, Vet_approved Phase 2, Phase 3 37517-28-5 37768
3
Cefoxitin Approved Phase 2, Phase 3 35607-66-0 441199
4
Cefotaxime Approved Phase 2, Phase 3 63527-52-6 456256 5742673
5
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
6
Moxifloxacin Approved, Investigational Phase 2, Phase 3 354812-41-2, 151096-09-2 152946
7
Imipenem Approved Phase 2, Phase 3 64221-86-9, 74431-23-5 104838
8
Clofazimine Approved, Investigational Phase 2, Phase 3 2030-63-9 2794
9
Rifabutin Approved, Investigational Phase 2, Phase 3 72559-06-9 6323490 46783538
10
Trimethoprim Approved, Vet_approved Phase 2, Phase 3 738-70-5 5578
11
Sulfamethoxazole Approved Phase 2, Phase 3 723-46-6 5329
12
Linezolid Approved, Investigational Phase 2, Phase 3 165800-03-3 441401
13
Bedaquiline Approved Phase 2, Phase 3 843663-66-1
14
Azithromycin Approved Phase 2, Phase 3 83905-01-5 447043 55185
15
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
16
Ethambutol Approved Phase 2, Phase 3 74-55-5 3279 14052
17 Anti-Bacterial Agents Phase 2, Phase 3
18 Anti-Infective Agents Phase 2, Phase 3
19 Antibiotics, Antitubercular Phase 2, Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
22 Trimethoprim, Sulfamethoxazole Drug Combination Phase 2, Phase 3
23 Antitubercular Agents Phase 2, Phase 3
24 Norgestimate, ethinyl estradiol drug combination Phase 2, Phase 3
25 Antimalarials Phase 2, Phase 3
26 Antiparasitic Agents Phase 2, Phase 3
27 Antiprotozoal Agents Phase 2, Phase 3
28 Anti-Inflammatory Agents Phase 2, Phase 3
29
Nitric Oxide Approved Phase 2 10102-43-9 145068
30 Vasodilator Agents Phase 2
31 Respiratory System Agents Phase 2
32 Anti-Asthmatic Agents Phase 2
33 Neurotransmitter Agents Phase 2
34 Protective Agents Phase 2
35 Antioxidants Phase 2
36 Bronchodilator Agents Phase 2
37 Endothelium-Dependent Relaxing Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Recruiting NCT04310930 Phase 2, Phase 3 Amikacin;Tigecycline;Imipenem;Cefoxitin;Azithromycin;Clarithromycin;Clofazimine;Ethambutol;Amikacin;Linezolid;co-trimoxazole;Doxycycline;Moxifloxacin;Bedaquiline;Rifabutin
2 A Prospective, Open Labeled, Multi-Center, Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With NTM (Specifically MABSC) Completed NCT03208764 Phase 2 Nitric Oxide
3 Use of Tigecycline for Treatment of Serious Infection Due to Rapidly Growing Mycobacteria (Especially M.Abscessus) Completed NCT00600600 Phase 2 Tigecycline
4 An Open-label Study of Efficacy, Safety and Tolerability of Liposomal Amikacin for Inhalation (LAI) Once Daily in Addition to Standard Multi-antibiotic Therapy in the Treatment of Mycobacterium Abscessus Lung Disease Completed NCT03038178 Phase 2 LAI plus multi-drug regimen
5 The Role of Inflammasome in Inflammatory Macrophage in Mycobacterium Avium Complex-lung Disease and Mycobacterium Abscessus-lung Disease Unknown status NCT02005094

Search NIH Clinical Center for Mycobacterium Abscessus

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Genetic Tests for Mycobacterium Abscessus

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Anatomical Context for Mycobacterium Abscessus

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MalaCards organs/tissues related to Mycobacterium Abscessus:

40
Lung, T Cells, Eye, Neutrophil, Cortex, Breast, Myeloid
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Publications for Mycobacterium Abscessus

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Articles related to Mycobacterium Abscessus:

(show top 50) (show all 1535)
# Title Authors PMID Year
1
[Mycobacterium abscessus subsp. abscessus canaliculitis]. 61
33507005 2021
2
Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes. 61
33799414 2021
3
Mycobacterium abscessus infection after facial injection of argireline: A case report. 61
33748252 2021
4
The Prophage and Plasmid Mobilome as a Likely Driver of Mycobacterium abscessus Diversity. 61
33785627 2021
5
Mab_3083c Is a Homologue of RNase J and Plays a Role in Colony Morphotype, Aggregation, and Sliding Motility of Mycobacterium abscessus. 61
33805851 2021
6
Comparison of drug-susceptibility patterns and gene sequences associated with clarithromycin and azithromycin resistance in Mycobacterium abscessus complex isolates and evaluation of the accumulation of intrinsic macrolide resistance. 61
33570485 2021
7
Mycobacterium abscessus Strain Morphotype Determines Phage Susceptibility, the Repertoire of Therapeutically Useful Phages, and Phage Resistance. 61
33785625 2021
8
In vitro susceptibility of Mycobacterium abscessus complex and feasibility of standardizing treatment regimens. 61
33338230 2021
9
Pulmonary coinfection due to Mycobacterium abscessus subsp. massiliense and Cryptococcus neoformans var. grubii. 61
33790067 2021
10
Antimicrobial susceptibility profiles of Mycobacterium abscessus complex isolates from respiratory specimens in Shanghai, China. 61
33689828 2021
11
Prediction of 1-year treatment outcome using the early sputum culture conversion status in Mycobacterium abscessus pulmonary disease. 61
33762212 2021
12
Association between 16S rRNA gene mutations and susceptibility to amikacin in Mycobacterium avium Complex and Mycobacterium abscessus clinical isolates. 61
33731862 2021
13
[Progress in the treatment of Mycobacterium abscessus pulmonary disease]. 61
33721940 2021
14
Genome Sequence of Mycobacterium abscessus Phage phiT45-1. 61
33707330 2021
15
Mycobacterium abscessus biofilms have viscoelastic properties which may contribute to their recalcitrance in chronic pulmonary infections. 61
33658597 2021
16
Mycobacterium abscessus soft tissue infection: a rare and unusual cluster of presentations to a rural surgical service. 61
32706151 2021
17
Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities. 61
33645845 2021
18
A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense. 61
33775997 2021
19
The Frequency and Related Factors of Non-Tuberculosis Mycobacteria Infections among Patients with Cystic Fibrosis. 61
33682254 2021
20
High Prevalence of Nontuberculous Mycobacteria in Cystic Fibrosis Patients in Tropical French Reunion Island. 61
33427803 2021
21
Prevalence and speciation of non-tuberculous mycobacteria among pulmonary and extrapulmonary tuberculosis suspects in South India. 61
33618276 2021
22
The double-edged sword of Tregs in M tuberculosis, M avium, and M absessus infection. 61
33713043 2021
23
Simultaneous catheter removal and reinsertion, is it acceptable in M. abscessus exit site infection? 61
33728600 2021
24
Clinical risk factors related to treatment failure in Mycobacterium abscessus lung disease. 61
32875518 2021
25
Mycobacterium abscessus exit-site infection in peritoneal dialysis patients: should we ever aim to salvage the catheter? 61
32662049 2021
26
An immunocompetent female with Mycobacterium abscessus cervical lymphadenitis mimicking malignancy. 61
33601034 2021
27
A child with acute myeloid leukemia complicated by calcaneal osteomyelitis due to Mycobacterium abscessus infection after induction chemotherapy successfully salvaged with bedaquiline and clofazimine. 61
33160065 2021
28
Mycobacterium abscessus Gastric Band Infection Complicated by Immune Reconstitution Inflammatory Syndrome and Cured in the Context of Allogeneic Hematopoietic Stem Cell Transplantation. 61
33553476 2021
29
Beyond phenotype: The genomic heterogeneity of co-infecting Mycobacterium abscessus smooth and rough colony variants in cystic fibrosis patients. 61
33610476 2021
30
Rifabutin Is Inactivated by Mycobacterium abscessus Arr. 61
33318008 2021
31
Outcomes of inhaled amikacin-containing multidrug regimens for Mycobacterium abscessus pulmonary disease. 61
33621600 2021
32
Preliminary, Real-world, Multicenter Experience With Omadacycline for Mycobacterium abscessus Infections. 61
33628856 2021
33
Bipolar Distribution of Minimum Inhibitory Concentration of Q203 Across Mycobacterial Species. 61
33646044 2021
34
In Vitro Susceptibility Testing of Omadacycline against Nontuberculous Mycobacteria. 61
33288634 2021
35
A novel DNA chromatography method to discriminate Mycobacterium abscessus subspecies and macrolide susceptibility. 61
33446475 2021
36
Feline mycobacterial disease in northern California: Epidemiology, clinical features, and antimicrobial susceptibility. 61
33346952 2021
37
Developing Tadpole Xenopus laevis as a Comparative Animal Model to Study Mycobacterium abscessus Pathogenicity. 61
33467397 2021
38
Genome Sequence of Mycobacterium abscessus Phage phiT46-1. 61
33446600 2021
39
Genitourinary non-tuberculous mycobacterial (GU-NTM) infections: A single institution experience in South India. 61
33641853 2021
40
Carbonyl Cyanide 3-Chlorophenylhydrazone (CCCP) Exhibits Direct Antibacterial Activity Against Mycobacterium abscessus. 61
33790590 2021
41
Pulmonary Mycobacterium abscessus and response to treatment in an outpatient setting: Case series. 61
33707380 2021
42
Longitudinal non-cystic fibrosis trends of pulmonary Mycobacterium abscessus disease from 2010 to 2017: spread of the "globally successful clone" in Asia. 61
33532483 2021
43
COVID-19 Coinfection with Mycobacterium abscessus in a Patient with Multiple Myeloma. 61
33505740 2021
44
Thoracoscopic right middle lobectomy for Mycobacterium abscessus in a young patient suspected of having congenital immunodeficiency. 61
32776415 2021
45
Coinfection by Talaromyces marneffei and Mycobacterium abscessus in a human immunodeficiency virus-negative patient with anti-interferon-γ autoantibody: a case report. 61
33435770 2021
46
Sweet Syndrome precipitated by Mycobacterium abscessus in a Laotian Man with Autoantibodies to Interferon Gamma. 61
33533284 2021
47
Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery. 61
33071055 2021
48
Disseminated Mycobacterium abscessus infection and native valve endocarditis. 61
33489744 2021
49
Peritoneal Dialysis-Associated Peritonitis Caused by Mycobacterium abscessus in Children-A Case Report. 61
33447640 2021
50
Co-Infection Pneumonia with Mycobacterium abscessus and Pneumocystis jiroveci in a Patient without HIV Infection Diagnosed by Metagenomic Next-Generation Sequencing. 61
33692629 2021
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Variations for Mycobacterium Abscessus

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Expression for Mycobacterium Abscessus

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Search GEO for disease gene expression data for Mycobacterium Abscessus.
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Pathways for Mycobacterium Abscessus

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Pathways related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.74 TNF TLR2 TLR1 SYK SQSTM1 SERPINA1
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.21 TNF SYK SQSTM1 IFNGR2 HMOX1 CXCL8
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.85 TNF TLR2 TLR1 SYK SQSTM1 NLRP3
4
Measles 36
Show member pathways
 12.64 TNF TLR2 SYK NLRP3 IFNGR2 CXCL8
5
Salmonella infection (KEGG) 36
Show member pathways
 12.6 TNF TLR2 NLRP3 CXCL8
6
NF-kappaB Signaling 4
12.42 TNF TLR2 TLR1 SYK HMOX1
7
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.33 TNF TLR2 TLR1 NLRP3 HMOX1 CXCL8
8
Shigellosis 36
12.28 TNF SQSTM1 NLRP3 CXCL8
9
IL-17 Family Signaling Pathways 64
Show member pathways
 12.22 TNF TLR2 CXCL8 CFTR
10
C-type lectin receptor signaling pathway 36
Show member pathways
 12.1 TNF SYK NLRP3 CLEC7A
11
Necroptosis 36
Show member pathways
 12.08 TNF SQSTM1 NLRP3 IFNGR2
12
Colorectal Cancer Metastasis 63
12.05 TNF TLR2 TLR1 IFNGR2
13
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.04 TNF TLR2 TLR1 SQSTM1 CXCL8
14
NRF2 pathway 1
11.98 SQSTM1 SERPINA1 HMOX1
15
Fluid shear stress and atherosclerosis 36
11.96 TNF SQSTM1 HMOX1
16
Yersinia infection 36
11.95 TNF NLRP3 CXCL8
17
Osteoclast differentiation 36
11.93 TNF SYK SQSTM1 IFNGR2
18
Interleukin-4 and 13 signaling 65
11.87 TNF HMOX1 CXCL8
19
NF-kappa B signaling pathway 36
11.82 TNF SYK CXCL8
20
Amoebiasis 36
11.8 TNF TLR2 CXCL8
21
Rheumatoid arthritis 36
11.76 TNF TLR2 CXCL8
22
Phagocytosis of Microbes 63
11.71 TLR2 TLR1 CLEC7A
23
Tuberculosis 36
11.69 TNF TLR2 TLR1 SYK IFNGR2 CLEC7A
24
Pertussis 36
11.66 TNF NLRP3 CXCL8
25
Th1 Differentiation Pathway 64
Show member pathways
 11.61 TNF TLR2 TLR1 IFNGR2
26
Legionellosis 36
11.51 TNF TLR2 CXCL8
27
Malaria 36
11.44 TNF TLR2 CXCL8
28
Lung fibrosis 1
11.42 TNF SERPINA1 HMOX1 CXCL8
29
Bacterial infections in CF airways 23
Show member pathways
 11.32 TNF TLR2 TLR1 IFNGR2 CXCL8 CFTR
30
IL1 and megakaryocytes in obesity 1
11.07 TLR2 TLR1 NLRP3
31
EBV LMP1 signaling 1
11.03 TNF CXCL8
32
Overview of nanoparticle effects 1
10.93 TNF HMOX1 CXCL8
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GO Terms for Mycobacterium Abscessus

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Cellular components related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.43 SQSTM1 SERPINA1 NLRP3 IFNGR2 HMOX1 CFTR
2 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR2 TLR1

Biological processes related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.01 TLR2 TLR1 SYK NLRP3 CLEC7A
2 immune system process GO:0002376 10.01 TLR2 TLR1 SYK SQSTM1 NLRP3 CLEC7A
3 intracellular signal transduction GO:0035556 9.95 SYK SQSTM1 HMOX1 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 9.92 TNF IFNGR2 HMOX1 CXCL8
5 inflammatory response GO:0006954 9.8 TNF TLR2 TLR1 NLRP3 CXCL8 CLEC7A
6 positive regulation of interleukin-1 beta production GO:0032731 9.76 TNF NLRP3 CLEC7A
7 defense response GO:0006952 9.76 TNF TLR1 NLRP3 CXCL8
8 positive regulation of protein complex assembly GO:0031334 9.75 TNF SYK CLEC7A
9 positive regulation of interleukin-12 production GO:0032735 9.7 TLR2 SYK CLEC7A
10 positive regulation of tumor necrosis factor production GO:0032760 9.67 TLR2 TLR1 SYK CLEC7A
11 positive regulation of interleukin-4 production GO:0032753 9.65 SYK NLRP3
12 positive regulation of chemokine production GO:0032722 9.65 TNF TLR2 HMOX1
13 positive regulation of superoxide anion generation GO:0032930 9.64 SYK CLEC7A
14 embryonic digestive tract development GO:0048566 9.64 TNF CXCL8
15 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.63 SYK CLEC7A
16 cell activation GO:0001775 9.63 TLR2 TLR1
17 response to molecule of bacterial origin GO:0002237 9.62 TLR2 CXCL8
18 cellular response to bacterial lipopeptide GO:0071221 9.61 TLR2 TLR1
19 positive regulation of interleukin-10 production GO:0032733 9.61 TLR2 SYK CLEC7A
20 regulation of cytokine secretion GO:0050707 9.6 TLR2 TLR1
21 positive regulation of killing of cells of other organism GO:0051712 9.59 SYK CLEC7A
22 cellular response to molecule of fungal origin GO:0071226 9.57 SYK CLEC7A
23 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.56 TLR2 TLR1
24 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.56 CLEC7A NLRP3 SYK TNF
25 leukocyte activation involved in immune response GO:0002366 9.55 SYK CLEC7A
26 cellular response to triacyl bacterial lipopeptide GO:0071727 9.51 TLR2 TLR1
27 response to bacterial lipoprotein GO:0032493 9.49 TLR2 TLR1
28 microglial cell activation GO:0001774 9.46 TNF TLR2 TLR1 IFNGR2
29 detection of triacyl bacterial lipopeptide GO:0042495 9.4 TLR2 TLR1
30 positive regulation of interleukin-6 production GO:0032755 9.35 TNF TLR2 TLR1 SYK CLEC7A
31 positive regulation of interleukin-8 production GO:0032757 9.02 TNF TLR2 TLR1 SYK CLEC7A

Molecular functions related to Mycobacterium Abscessus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TNF TLR2 TLR1 SQSTM1 SERPINA1 NLRP3
2 peptidoglycan binding GO:0042834 9.4 TLR2 NLRP3
3 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.37 TLR2 TLR1
4 NAD(P)+ nucleosidase activity GO:0050135 9.32 TLR2 TLR1
5 pattern recognition receptor activity GO:0038187 9.26 TLR2 CLEC7A
6 lipopeptide binding GO:0071723 9.16 TLR2 TLR1
7 Toll-like receptor binding GO:0035325 8.62 TLR2 SYK
Sources

Sources for Mycobacterium Abscessus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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