MCID: MYC017
MIFTS: 43

Mycobacterium Kansasii

Categories: Rare diseases

Aliases & Classifications for Mycobacterium Kansasii

MalaCards integrated aliases for Mycobacterium Kansasii:

Name: Mycobacterium Kansasii 53
Infection Due to Mycobacterium Kansasii 73
Mycobacterium Kansasii Infection 53
M. Kansasii 53

Classifications:



External Ids:

UMLS 73 C0275706

Summaries for Mycobacterium Kansasii

MalaCards based summary : Mycobacterium Kansasii, also known as infection due to mycobacterium kansasii, is related to septic arthritis and silicosis. An important gene associated with Mycobacterium Kansasii is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Isoniazid and Ethambutol have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotype is hematopoietic system.

Wikipedia : 76 Mycobacterium kansasii is a bacterium in the Mycobacterium family. The genus includes species known to... more...

Related Diseases for Mycobacterium Kansasii

Diseases related to Mycobacterium Kansasii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.3 CXCL8 TLR2
2 silicosis 29.9 CXCL8 NLRP3
3 mastitis 29.5 CXCL8 TLR2
4 peritonitis 29.3 CXCL8 TLR2
5 mycobacterium chelonae 29.1 CD14 CXCL8 TLR2
6 mycobacterium abscessus 28.8 CXCL8 NLRP3 TLR2
7 viral meningitis 10.3 CD14 CXCL8
8 arthritis 10.3
9 osteomyelitis 10.3
10 tenosynovitis 10.3
11 acquired immunodeficiency syndrome 10.2
12 mycobacterium marinum 10.2
13 aseptic meningitis 10.2 CXCL8 NLRP3
14 pyoderma gangrenosum 10.2 CXCL8 NLRP3
15 wells syndrome 10.2 CXCL8 NLRP3
16 pneumonia 10.1
17 mycobacterium fortuitum 10.1
18 pericarditis 10.1
19 lung disease 10.1
20 paroxysmal nocturnal hemoglobinuria 10.1 CD14 PLCG1
21 conjunctivitis 10.1 CXCL8 NLRP3
22 leukemia 10.1
23 lymphadenitis 10.1
24 mycobacterium xenopi 10.1
25 monocytic leukemia 10.1 CD14 CXCL8
26 pneumoconiosis 10.1 CXCL8 NLRP3
27 pulmonary tuberculosis 10.0
28 hepatitis 10.0
29 bursitis 10.0
30 cellulitis 10.0
31 mononeuropathy of the median nerve, mild 10.0
32 mediastinitis 10.0
33 carpal tunnel syndrome 10.0
34 systemic lupus erythematosus 10.0
35 lupus erythematosus 10.0
36 bone inflammation disease 10.0 CXCL8 NLRP3
37 neurosyphilis 10.0 CXCL8 TLR2
38 haemophilus influenzae 10.0 CXCL8 TLR2
39 sebaceous gland disease 10.0 CXCL8 TLR2
40 type i 10.0
41 mycobacterium gordonae 10.0
42 myelodysplastic syndrome 10.0
43 hairy cell leukemia 10.0
44 rheumatoid arthritis 10.0
45 olecranon bursitis 10.0
46 tuberculous meningitis 9.9 CXCL8 TLR2
47 middle ear disease 9.9 CXCL8 TLR2
48 invasive aspergillosis 9.9 CXCL8 TLR2
49 bacterial vaginosis 9.9 CXCL8 TLR2
50 leptospirosis 9.9 CXCL8 TLR2

Graphical network of the top 20 diseases related to Mycobacterium Kansasii:



Diseases related to Mycobacterium Kansasii

Symptoms & Phenotypes for Mycobacterium Kansasii

MGI Mouse Phenotypes related to Mycobacterium Kansasii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.02 CD14 FN1 NLRP3 PLCG1 TLR2

Drugs & Therapeutics for Mycobacterium Kansasii

Drugs for Mycobacterium Kansasii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
2
Ethambutol Approved Phase 3 74-55-5 3279 14052
3
Kanamycin Approved, Investigational, Vet_approved Phase 3 8063-07-8, 59-01-8 6032
4
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
5
Clofazimine Approved, Investigational Phase 3 2030-63-9 2794
6
Ofloxacin Approved Phase 3 82419-36-1 4583
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
8
Pyrazinamide Approved, Investigational Phase 3 98-96-4 1046
9
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
10
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
11
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
12
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
13
Prothionamide Approved, Investigational Phase 3 14222-60-7 666418
14
Bedaquiline Approved Phase 3 843663-66-1
15
Polyestradiol phosphate Approved Phase 3 28014-46-2
16 Renal Agents Phase 3
17 Fluoroquinolones Phase 3
18 Contraceptive Agents Phase 3
19 Contraceptives, Oral Phase 3
20 Contraceptives, Oral, Combined Phase 3
21 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
22 Cytochrome P-450 Enzyme Inhibitors Phase 3
23 Topoisomerase Inhibitors Phase 3
24 Norgestimate, ethinyl estradiol drug combination Phase 3
25 Diarylquinolines Phase 3
26 Anti-Bacterial Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Estradiol 17 beta-cypionate Phase 3
29 Hypolipidemic Agents Phase 3
30 Estradiol 3-benzoate Phase 3
31 Anti-Infective Agents Phase 3
32 Lipid Regulating Agents Phase 3
33 Anti-Inflammatory Agents Phase 3
34 Antitubercular Agents Phase 3
35 Antimetabolites Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Recruiting NCT02409290 Phase 3 Regimen A locally-used WHO-approved MDR-TB regimen;Moxifloxacin;Clofazimine;Ethambutol;Pyrazinamide;Isoniazid;Prothionamide;Kanamycin;Levofloxacin;Bedaquiline
2 The Incidence of Nontuberculous Mycobacterial Pulmonary Infection in Bilateral Bronchiectasis and Bronchiolitis Unknown status NCT01354912

Search NIH Clinical Center for Mycobacterium Kansasii

Genetic Tests for Mycobacterium Kansasii

Anatomical Context for Mycobacterium Kansasii

MalaCards organs/tissues related to Mycobacterium Kansasii:

41
Lung, Skin, Testes, T Cells, Lymph Node, Monocytes, Liver

Publications for Mycobacterium Kansasii

Articles related to Mycobacterium Kansasii:

(show top 50) (show all 459)
# Title Authors Year
1
<i>Mycobacterium kansasii</i> osteomyelitis - a masquerading disease. ( 29568531 )
2018
2
MALDI Spectra Database for Rapid Discrimination and Subtyping of <i>Mycobacterium kansasii</i>. ( 29670585 )
2018
3
Molecular typing of Mycobacterium kansasii using pulsed-field gel electrophoresis and a newly designed variable-number tandem repeat analysis. ( 29535391 )
2018
4
First case of acute granulomatous interstitial nephritis with immune reconstitution inflammatory syndrome in a patient with HIV coinfected with disseminated <i>Mycobacterium kansasii</i>. ( 29477993 )
2018
5
Drug susceptibility profiling and genetic determinants of drug resistance in<i>Mycobacterium kansasii</i>. ( 29437627 )
2018
6
Clofazimine for the treatment of <i>Mycobacterium kansasii</i>. ( 29844047 )
2018
7
Clinical, radiological and molecular features of Mycobacterium kansasii pulmonary disease. ( 29858008 )
2018
8
Whole genome sequence of Mycobacterium kansasii isolates of the genotype 1 from Brazilian patients with pulmonary disease demonstrates considerable heterogeneity. ( 29947722 )
2018
9
Disseminated mycobacteriosis caused by Mycobacterium kansasii in a pot-bellied pig. ( 29855226 )
2018
10
Dynamics of Immune Responses during Experimental <i>Mycobacterium kansasii</i> Infection of Cynomolgus Monkeys <i>(Macaca fascicularis)</i>. ( 29967568 )
2018
11
Mycobacterium kansasii Isolated from Tuberculinpositive Rhesus Macaques (Macaca mulatta) in the Absence of Disease. ( 28830585 )
2017
12
Mycobacterium kansasii Infection in a Patient Receiving Biologic Therapy-Not All Reactive Interferon Gamma Release Assays Are Tuberculosis. ( 28317629 )
2017
13
Systemic Mycobacterium kansasii Infection in a Domestic Shorthair Cat. ( 28942306 )
2017
14
Mycobacterium kansasii: A Rare Cause of Brain Abscess. ( 28104110 )
2017
15
Disseminated Mycobacterium kansasii infection with cutaneous lesions in an immunocompetent patient. ( 28712930 )
2017
16
Mycobacterium persicum sp. nov., a novel species closely related to Mycobacterium kansasii and Mycobacterium gastri. ( 28629501 )
2017
17
Complete Genome Sequences of Mycobacterium kansasii Strains Isolated from Rhesus Macaques. ( 28428296 )
2017
18
A Patient-Based Analysis of the Geographic Distribution of Mycobacterium avium complex, Mycobacterium abscessus, and Mycobacterium kansasii Infections in the United States. ( 28390637 )
2017
19
Mycobacterium Kansasii ( 28613656 )
2017
20
Disseminated cutaneous Mycobacterium kansasii infection presenting with Rosai-Dorfman disease-like histological features in a patient carrying anti-interferon-I^ autoantibodies. ( 28836691 )
2017
21
Mycotic aortic pseudoaneurysms in a patient with active Mycobacterium kansasii infection. ( 28342513 )
2017
22
Mycobacterium kansasii Pneumonia with Mediastinal Lymphadenitis in a Patient with Acute Myeloid Leukemia: Successful Treatment to Stem Cell Transplantation. ( 28271647 )
2017
23
Mycobacterium kansasii. ( 28185617 )
2017
24
Draft Genome Sequences of Mycobacterium kansasii Clinical Strains. ( 28572311 )
2017
25
Osteomyelitis due to Mycobacterium kansasii in a patient with sarcoidosis. ( 28529884 )
2017
26
Isolated Mycobacterium kansasii wound infection and Osteomyelitis in an immunocompetent patient. ( 28031850 )
2016
27
Mediastinal and Disseminated Mycobacterium kansasii Disease in GATA2 Deficiency. ( 27607353 )
2016
28
The importance of computed tomography of the chest in cases of suspected infection with nontuberculous mycobacteria (Mycobacterium kansasii). ( 27777490 )
2016
29
Pulmonary infection caused by Mycobacterium kansasii: findings on computed tomography of the chest. ( 27777472 )
2016
30
Proposal of a new method for subtyping of Mycobacterium kansasii based upon PCR restriction enzyme analysis of the tuf gene. ( 26830053 )
2016
31
Interferon-gamma release assays in patients with Mycobacterium kansasii pulmonary infection: A retrospective survey. ( 27025204 )
2016
32
Mycobacterium kansasii Subtype I Is Associated With Clarithromycin Resistance in China. ( 28082964 )
2016
33
Pulmonary Mycobacterium kansasii disease in immunocompetent host: Treatment outcomes with short-course chemotherapy. ( 27934834 )
2016
34
Isoniazid-resistant Mycobacterium kansasii in an HIV-positive patient, and possible development of immune reconstitution inflammatory syndrome after initiation of highly active antiretroviral therapy: case report. ( 26603644 )
2016
35
Draft Genome Sequences of Mycobacterium kansasii Strains 1010001454, 1010001458, 1010001468, 1010001493, 1010001495, and 1010001469, Isolated from Environmental Sources. ( 27257194 )
2016
36
MKAN27435 Is Required for the Biosynthesis of Higher Subclasses of Lipooligosaccharides in Mycobacterium kansasii. ( 25893968 )
2015
37
Molecular characterisation of clinical and environmental isolates of Mycobacterium kansasii isolates from South African gold mines. ( 25719478 )
2015
38
[THE GENETIC EXAMINATION OF BRONCHIAL LAVAGE ENABLES THE PROMPT DIAGNOSIS OF PULMONARY MYCOBACTERIUM KANSASII--A CASE REPORT]. ( 26665518 )
2015
39
A Case of Pulmonary Mycobacterium kansasii Disease Complicated with Tension Pneumothorax. ( 26508923 )
2015
40
Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient. ( 26372924 )
2015
41
Mycobacterium kansasii causing chronic monoarticular synovitis in a patient with HIV/AIDS. ( 26629306 )
2015
42
Fatal aortic pseudoaneurysm from disseminated Mycobacterium kansasii infection: case report. ( 25537975 )
2015
43
Cutaneous infection with Mycobacterium kansasii in a patient with myelodysplastic syndrome and Sweet syndrome. ( 26244358 )
2015
44
Rapid Drug Tolerance and Dramatic Sterilizing Effect of Moxifloxacin Monotherapy in a Novel Hollow-Fiber Model of Intracellular Mycobacterium kansasii Disease. ( 25645830 )
2015
45
Clinical Significance of Mycobacterium kansasii Isolates from Respiratory Specimens. ( 26431540 )
2015
46
Sweet's syndrome associated with Mycobacterium kansasii infection in an immunocompetent woman. ( 26086480 )
2015
47
Insights on the Emergence of Mycobacterium tuberculosis from the Analysis of Mycobacterium kansasii. ( 25716827 )
2015
48
Disseminated Mycobacterium kansasii disease in complete DiGeorge syndrome. ( 26048260 )
2015
49
Comparison of the clinical courses and chemotherapy outcomes in metastatic colorectal cancer patients with and without active Mycobacterium tuberculosis or Mycobacterium kansasii infection: a retrospective study. ( 25326267 )
2014
50
Mycobacterium kansasii cutaneous infection in a patient with sarcoidosis treated with anti-TNF agents. ( 24773076 )
2014

Variations for Mycobacterium Kansasii

Expression for Mycobacterium Kansasii

Search GEO for disease gene expression data for Mycobacterium Kansasii.

Pathways for Mycobacterium Kansasii

Pathways related to Mycobacterium Kansasii according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CD14 CXCL8 FN1 NLRP3 PLCG1 TLR2
2
Show member pathways
12.65 CD14 CXCL8 NLRP3 TLR2
3 12.51 CXCL8 FN1 PLCG1
4
Show member pathways
12.48 CD14 PLCG1 TLR2
5
Show member pathways
12.47 CXCL8 NLRP3 TLR2
6
Show member pathways
12.25 CXCL8 PLCG1 TLR2
7 11.99 FN1 PLCG1 TLR2
8
Show member pathways
11.93 CD14 FN1 PLCG1 TLR2
9
Show member pathways
11.91 CD14 CXCL8 TLR2
10 11.61 CXCL8 PLCG1
11
Show member pathways
11.6 CD14 CXCL8
12 11.6 CXCL8 FN1 PLCG1
13 11.58 CXCL8 TLR2
14 11.56 CD14 CXCL8 PLCG1
15 11.55 CD14 CXCL8
16 11.47 FN1 PLCG1 TLR2
17
Show member pathways
11.47 CD14 CXCL8 FN1 TLR2
18 11.43 FN1 PLCG1
19 11.4 CXCL8 PLCG1
20 11.38 CD14 CXCL8 NLRP3
21 11.37 CXCL8 FN1
22 11.27 CXCL8 TLR2
23 11.21 CXCL8 FN1
24 11.07 CXCL8 FN1
25 11.07 CD14 CXCL8 TLR2
26 10.93 NLRP3 TLR2
27 10.91 CD14 CXCL8 FN1 TLR2
28 10.76 CXCL8 FN1

GO Terms for Mycobacterium Kansasii

Biological processes related to Mycobacterium Kansasii according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD14 NLRP3 TLR2
2 innate immune response GO:0045087 9.77 CD14 NLRP3 TLR2
3 intracellular signal transduction GO:0035556 9.76 CXCL8 NLRP3 PLCG1
4 inflammatory response GO:0006954 9.71 CD14 CXCL8 NLRP3 TLR2
5 response to lipopolysaccharide GO:0032496 9.67 CD14 CXCL8 TLR2
6 cellular response to lipopolysaccharide GO:0071222 9.63 CD14 CXCL8 NLRP3
7 defense response to Gram-positive bacterium GO:0050830 9.61 NLRP3 TLR2
8 calcium-mediated signaling GO:0019722 9.58 CXCL8 PLCG1
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.57 CD14 TLR2
10 positive regulation of tumor necrosis factor production GO:0032760 9.56 CD14 TLR2
11 toll-like receptor signaling pathway GO:0002224 9.55 CD14 TLR2
12 response to bacterium GO:0009617 9.54 CD14 NLRP3
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.52 CD14 TLR2
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.51 CD14 TLR2
15 positive regulation of interleukin-8 secretion GO:2000484 9.48 CD14 TLR2
16 cellular response to lipoteichoic acid GO:0071223 9.43 CD14 TLR2
17 cellular response to diacyl bacterial lipopeptide GO:0071726 9.37 CD14 TLR2
18 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.32 CD14 TLR2
19 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.26 CD14 TLR2
20 cellular response to triacyl bacterial lipopeptide GO:0071727 9.16 CD14 TLR2
21 cytokine secretion involved in immune response GO:0002374 8.96 NLRP3 TLR2
22 response to molecule of bacterial origin GO:0002237 8.8 CD14 CXCL8 TLR2

Molecular functions related to Mycobacterium Kansasii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 CD14 TLR2
2 peptidoglycan binding GO:0042834 8.96 NLRP3 TLR2
3 lipopeptide binding GO:0071723 8.62 CD14 TLR2

Sources for Mycobacterium Kansasii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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