MCID: MYC084
MIFTS: 55

Mycobacterium Tuberculosis 1

Categories: Rare diseases, Infectious diseases, Reproductive diseases, Respiratory diseases, Endocrine diseases

Aliases & Classifications for Mycobacterium Tuberculosis 1

MalaCards integrated aliases for Mycobacterium Tuberculosis 1:

Name: Mycobacterium Tuberculosis 1 57
Tuberculosis 57 12 76 53 59 55 43 3 44 15 73
Tuberculosis, Susceptibility to 57 13 6
Tuberculoma 44 73
Tb 53 3
Mycobacterium Tuberculosis, Susceptibility to, 1 57
Kochs Disease 53
Mtbs1 57

Classifications:



External Ids:

OMIM 57 607949
Disease Ontology 12 DOID:399
SNOMED-CT 68 15202009
Orphanet 59 ORPHA3389
MESH via Orphanet 45 D014376
UMLS via Orphanet 74 C0041296
ICD10 33 A15-A19 A17.9

Summaries for Mycobacterium Tuberculosis 1

MedlinePlus : 43 Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but they can also damage other parts of the body. TB spreads through the air when a person with TB of the lungs or throat coughs, sneezes, or talks. If you have been exposed, you should go to your doctor for tests. You are more likely to get TB if you have a weak immune system. Symptoms of TB in the lungs may include A bad cough that lasts 3 weeks or longer Weight loss Loss of appetite Coughing up blood or mucus Weakness or fatigue Fever Night sweats Skin tests, blood tests, x-rays, and other tests can tell if you have TB. If not treated properly, TB can be deadly. You can usually cure active TB by taking several medicines for a long period of time. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Mycobacterium Tuberculosis 1, also known as tuberculosis, is related to pleural tuberculosis and multidrug-resistant tuberculosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Mycobacterium Tuberculosis 1 is CD244 (CD244 Molecule
Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.
Dysfunction Pattern: Regulation), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lungs, lymph nodes and pericardium, and related phenotypes are weight loss and fever

Disease Ontology : 12 A primary bacterial infectious disease that is located in lungs, located in lymph nodes, located in pericardium, located in brain, located in pleura or located in gastrointestinal tract, has material basis in Mycobacterium tuberculosis, which is transmitted by droplets released into the air when an infected person coughs or sneezes.

NIH Rare Diseases : 53 Tuberculosis (TB) is a contagious and often severe airborne disease caused by the TB bacterium, Mycobacterium tuberculosis. TB typically affects the lungs, but other organs of the body may be involved, as well. Not everyone who is infected with the TB bacterium becomes sick. TB bacterial infections only become "active disease" if the immune system can't stop them from growing. Classic signs and symptoms of active TB can include cough, weight loss, fever, night sweats, hemoptysis, chest pain, and fatigue. Symptoms involving areas of the body other than the lungs vary depending on which organ(s) are affected. TB is usually treated with a regimen of medications taken over a long period of time (often six to twelve months).

CDC : 3 TB Facebook

Wikipedia : 76 Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis... more...

Description from OMIM: 607949

Related Diseases for Mycobacterium Tuberculosis 1

Diseases in the Mycobacterium Tuberculosis 1 family:

Mycobacterium Tuberculosis 2 Mycobacterium Tuberculosis 3

Diseases related to Mycobacterium Tuberculosis 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 pleural tuberculosis 35.2 ADA IFNG TNF
2 multidrug-resistant tuberculosis 35.0 IL10 INHA SLC11A1 TNF
3 gastrointestinal tuberculosis 35.0 ADA IFNG
4 pericardial tuberculosis 34.9 ADA IFNG IL10
5 extrapulmonary tuberculosis 34.8 ADA IFNG IL10 SLC11A1 TLR2
6 abdominal tuberculosis 34.2 ADA IL12RB1
7 tuberculous meningitis 34.2 ADA TLR2 TNF
8 pulmonary tuberculosis 33.6 ADA IFNG IFNGR1 IL10 IL12RB1 IL4
9 mycobacterium tuberculosis, susceptibility to infection by 33.3 MTBS1 SLC11A1
10 miliary tuberculosis 12.5
11 urogenital tuberculosis 12.4
12 skeletal tuberculosis 12.3
13 laryngeal tuberculosis 12.3
14 lymph node tuberculosis 12.3
15 renal tuberculosis 12.3
16 hepatic tuberculosis 12.2
17 intestinal tuberculosis 12.2
18 central nervous system tuberculosis 12.2
19 splenic tuberculosis 12.2
20 oral tuberculosis 12.2
21 esophageal tuberculosis 12.2
22 bladder tuberculosis 12.2
23 ureter tuberculosis 12.0
24 cardiac tuberculosis 12.0
25 mycobacterium tuberculosis 3 12.0
26 mycobacterium tuberculosis x-linked 11.8
27 mycobacterium tuberculosis 2 11.8
28 punctate inner choroidopathy 11.2 IL10 TNF
29 mycoplasmal pneumonia 11.2 IFNG IL4
30 sennetsu fever 11.2 HSPD1 HSPE1
31 interferon gamma, receptor 1, deficiency 11.2 IFNG IFNGR1
32 nontuberculous mycobacterial lung disease 11.1 SLC11A1 TLR2 TNF
33 tuberculous peritonitis 11.1 ADA IFNG TNF
34 clonorchiasis 11.1 IFNG IL10 TNF
35 tropical endomyocardial fibrosis 11.1 IL10 IL4 TNF
36 post-transplant lymphoproliferative disease 11.1 IL10 SLC11A1 TNF
37 hyperlucent lung 11.1 IFNG IL10 IL4
38 intermediate uveitis 11.1 IFNG IL10 TNF
39 far eastern spotted fever 11.1 HSPD1 IFNG
40 staphylococcal toxic shock syndrome 11.1 IFNG TNF
41 spotted fever 11.1 IFNG IL10 TNF
42 myositis fibrosa 11.1 IFNG TLR2 TLR9
43 trachoma 11.1 HSPD1 IL10 TNF
44 tungiasis 11.1 IL10 IL4 TNF
45 hematopoietic stem cell transplantation 11.1 IFNG IL10 TNF
46 baylisascariasis 11.1 IFNG IL10 IL4
47 endomyocardial fibrosis 11.1 IL10 IL4 TNF
48 aseptic meningitis 11.1 IFNG IL10 TNF
49 microscopic colitis 11.1 IFNG IL4 TNF
50 mucocutaneous leishmaniasis 11.1 IL10 TLR9 TNF

Graphical network of the top 20 diseases related to Mycobacterium Tuberculosis 1:



Diseases related to Mycobacterium Tuberculosis 1

Symptoms & Phenotypes for Mycobacterium Tuberculosis 1

Clinical features from OMIM:

607949

Human phenotypes related to Mycobacterium Tuberculosis 1:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
2 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
3 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
4 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
5 abnormality of lung morphology 59 Frequent (79-30%)
6 abnormal lung morphology 32 frequent (33%) HP:0002088

UMLS symptoms related to Mycobacterium Tuberculosis 1:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Mycobacterium Tuberculosis 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 TNF ADA CD244 CISH IFNG IFNGR1
2 digestive/alimentary MP:0005381 10.1 ADA IFNG IFNGR1 IL10 IL4 INHA
3 immune system MP:0005387 10.07 ADA CD244 CISH IFNG IFNGR1 IL10
4 endocrine/exocrine gland MP:0005379 10.02 IL4 INHA TLR2 TNF ADA CISH
5 liver/biliary system MP:0005370 9.76 ADA IFNG IFNGR1 IL10 IL4 INHA
6 neoplasm MP:0002006 9.5 TNF IFNG IFNGR1 IL10 INHA SLC11A1
7 respiratory system MP:0005388 9.17 ADA CISH IFNG IL10 IL4 TLR2

Drugs & Therapeutics for Mycobacterium Tuberculosis 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Molecular Mechanism and the Role of NRAMP 1gene on Tuberculosis in Taiwan Aboriginal Tribes Population Completed NCT00266383
2 Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis Completed NCT00772408

Search NIH Clinical Center for Mycobacterium Tuberculosis 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: tuberculosis

Genetic Tests for Mycobacterium Tuberculosis 1

Anatomical Context for Mycobacterium Tuberculosis 1

The Foundational Model of Anatomy Ontology organs/tissues related to Mycobacterium Tuberculosis 1:

19
Lungs, Lymph Nodes, Pericardium, Brain, Pleura Or

MalaCards organs/tissues related to Mycobacterium Tuberculosis 1:

41
Lung, Brain, Lymph Node, Testes, Skin

Publications for Mycobacterium Tuberculosis 1

Variations for Mycobacterium Tuberculosis 1

ClinVar genetic disease variations for Mycobacterium Tuberculosis 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh37 Chromosome 3, 50649499: 50649499
2 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh38 Chromosome 3, 50612068: 50612068

Expression for Mycobacterium Tuberculosis 1

Search GEO for disease gene expression data for Mycobacterium Tuberculosis 1.

Pathways for Mycobacterium Tuberculosis 1

Pathways related to Mycobacterium Tuberculosis 1 according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CD209 CISH IFNG IFNGR1 IL10 IL12RB1
2
Show member pathways
13.31 CISH IFNG IFNGR1 IL10 IL12RB1 IL4
3
Show member pathways
12.96 CISH IFNG IFNGR1 IL10 TLR2 TLR9
4
Show member pathways
12.84 HSPD1 IFNG IFNGR1 IL10 IL12RB1 IL4
5
Show member pathways
12.77 CD209 IFNG IFNGR1 IL4 TLR2 TLR9
6
Show member pathways
12.76 IFNG IFNGR1 IL4 TLR2 TLR9 TNF
7
Show member pathways
12.57 CISH IFNG IFNGR1 IL10 IL12RB1 IL4
8 12.54 CISH IFNG IL10 IL4 TLR2 TLR9
9
Show member pathways
12.48 CD244 IFNG IFNGR1 IL4 TNF
10
Show member pathways
12.37 IFNG IL10 IL4 TNF
11
Show member pathways
12.37 IFNG IFNGR1 IL10 IL12RB1 IL4 TLR2
12
Show member pathways
12.28 IFNG IL4 TLR2 TNF
13
Show member pathways
12.24 IFNG IFNGR1 IL10 IL4 TLR2 TNF
14
Show member pathways
12.18 CD209 IL10 TLR9 TNF
15 12.16 IFNG IFNGR1 TLR2 TLR9 TNF
16
Show member pathways
12.15 IFNG IFNGR1 IL4 TLR2 TLR9 TNF
17
Show member pathways
12.07 IFNG IFNGR1 IL10 IL12RB1 TLR2 TLR9
18 11.86 IFNG IFNGR1 IL10 IL12RB1
19 11.86 IFNG IL10 TLR2 TNF
20 11.86 CD209 CD244 IFNG IL10 IL4 TNF
21 11.79 IFNG TLR2 TNF
22
Show member pathways
11.71 IFNG IL4 TNF
23 11.56 HSPD1 TLR2 TNF
24 11.54 CD244 IFNG IL10 IL12RB1 IL4 TNF
25
Show member pathways
11.51 IFNG IFNGR1 TNF
26 11.49 IL10 IL4 TNF
27 11.48 IFNG TLR2 TNF
28 11.48 CD209 HSPD1 IFNG IFNGR1 IL10 TLR2
29 11.46 IFNG IL10 IL4
30 11.46 IFNG IL10 TLR2 TLR9 TNF
31 11.37 IFNG IL10 TLR9 TNF
32 11.3 CD209 CD244 IFNG IL10 TLR9 TNF
33 11.29 IFNG IL10 IL4 TNF
34 11.27 IFNG IL4 TNF
35 11.17 IFNG IL10 IL4

GO Terms for Mycobacterium Tuberculosis 1

Cellular components related to Mycobacterium Tuberculosis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 ADA CD209 CD244 TNF
2 extracellular space GO:0005615 9.23 ADA HSPD1 IFNG IL10 IL4 INHA

Biological processes related to Mycobacterium Tuberculosis 1 according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.96 IL10 SLC11A1 TLR9 TNF
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.85 HSPD1 HSPE1 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.8 CISH IFNGR1 IL10 IL12RB1 IL4 TNF
4 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 TLR2 TLR9 TNF
5 T cell activation GO:0042110 9.77 ADA HSPD1 IL4
6 interleukin-12-mediated signaling pathway GO:0035722 9.77 IFNG IL10 IL12RB1
7 positive regulation of B cell proliferation GO:0030890 9.76 ADA IL4 TLR9
8 immune response GO:0006955 9.7 CD244 IFNG IL10 IL4 SLC11A1 TLR2
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.69 HSPD1 TLR2 TLR9
10 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR9
11 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
12 positive regulation of interleukin-8 secretion GO:2000484 9.68 CD244 TLR2
13 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.67 IFNG IFNGR1
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 TNF
15 positive regulation of interleukin-8 production GO:0032757 9.67 TLR2 TLR9 TNF
16 I-kappaB phosphorylation GO:0007252 9.66 TLR2 TLR9
17 regulation of cytokine secretion GO:0050707 9.66 TLR2 TLR9
18 positive regulation of T-helper 1 type immune response GO:0002827 9.65 IL12RB1 SLC11A1
19 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TLR9 TNF
20 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
23 type 2 immune response GO:0042092 9.62 IL10 IL4
24 negative regulation of interleukin-8 production GO:0032717 9.61 IL10 TLR9
25 positive regulation of interleukin-10 production GO:0032733 9.61 HSPD1 TLR2 TLR9
26 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR2 TLR9
27 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR9 TNF
28 tumor necrosis factor production GO:0032640 9.57 TLR2 TLR9
29 regulation of isotype switching GO:0045191 9.56 IL10 IL4
30 positive regulation of interleukin-6 production GO:0032755 9.56 HSPD1 TLR2 TLR9 TNF
31 positive regulation of interleukin-18 production GO:0032741 9.55 TLR2 TLR9
32 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
33 response to molecule of bacterial origin GO:0002237 9.54 IL10 TLR2 TLR9
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IFNG TNF
35 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 IFNG TNF
36 positive regulation of interferon-gamma production GO:0032729 9.26 HSPD1 IL12RB1 SLC11A1 TNF
37 positive regulation of interleukin-12 production GO:0032735 8.92 HSPD1 IFNG TLR2 TLR9
38 regulation of signaling receptor activity GO:0010469 10.04 IFNG IL10 IL4 INHA TNF
39 inflammatory response GO:0006954 10.03 IL10 SLC11A1 TLR2 TLR9 TNF
40 positive regulation of gene expression GO:0010628 10.03 IFNG SLC11A1 TLR2 TLR9 TNF

Molecular functions related to Mycobacterium Tuberculosis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL10 IL4 INHA TNF

Sources for Mycobacterium Tuberculosis 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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