Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MYD88D
MCID: MYD002
MIFTS: 48

Myd88 Deficiency (MYD88D)

Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
Sources

Aliases & Classifications for Myd88 Deficiency

About this section

MalaCards integrated aliases for Myd88 Deficiency:

Name: Myd88 Deficiency 57 53 25 59 75 29 6 40 73
Pyogenic Bacterial Infections Due to Myd88 Deficiency 53 25 59
Myd88d 57 75

Characteristics:

Orphanet epidemiological data:

59
pyogenic bacterial infections due to myd88 deficiency
Inheritance: Autosomal recessive; Age of onset: Childhood; Age of death: adolescent,late childhood;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare immunological diseases


External Ids:

OMIM 57 612260
Orphanet 59 ORPHA183713
ICD10 via Orphanet 34 D84.8
UMLS via Orphanet 74 C2677092
MedGen 42 C2677092
SNOMED-CT via HPO 69 386661006 50177009 234532001
UMLS 73 C2677092
Sources

Summaries for Myd88 Deficiency

About this section
Genetics Home Reference : 25 MyD88 deficiency is an inherited disorder of the immune system (primary immunodeficiency). This primary immunodeficiency affects the innate immune response, which is the body's early, nonspecific response to foreign invaders (pathogens). MyD88 deficiency leads to abnormally frequent and severe infections by a subset of bacteria known as pyogenic bacteria. (Infection with pyogenic bacteria causes the production of pus.) However, affected individuals have normal resistance to other common bacteria, viruses, fungi, and parasites. The most common infections in MyD88 deficiency are caused by the Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. Most people with this condition have their first bacterial infection before age 2, and the infections can be life-threatening in infancy and childhood. Infections become less frequent by about age 10.

MalaCards based summary : Myd88 Deficiency, also known as pyogenic bacterial infections due to myd88 deficiency, is related to waldenstroem's macroglobulinemia and pleuropneumonia. An important gene associated with Myd88 Deficiency is MYD88 (MYD88, Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. Affiliated tissues include myeloid, skin and kidney, and related phenotypes are fever and immunodeficiency

NIH Rare Diseases : 53 MYD88 deficiency is a rare primary immunodeficiency characterized by an increased susceptibility to certain types of bacterial infections. People affected by this condition generally have abnormally frequent and life-threatening infections caused by pyogenic bacteria (such as Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa). However, their immune response to other common bacteria, viruses, fungi, and parasites is normal. MYD88 deficiency is caused by changes (mutations) in the MYD88 gene and is inherited in an autosomal recessive manner. Management is focused on the prevention and early treatment of infections with appropriate antibiotics.

UniProtKB/Swiss-Prot : 75 MYD88 deficiency: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.

Wikipedia : 76 Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the... more...

Description from OMIM: 612260
Sources

Related Diseases for Myd88 Deficiency

About this section

Diseases related to Myd88 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 waldenstroem's macroglobulinemia 10.2 BTK MYD88
2 pleuropneumonia 10.2 IRAK4 MYD88
3 plasma protein metabolism disease 10.2 BTK MYD88
4 invasive pneumococcal disease, recurrent isolated, 1 10.1 IRAK4 TIRAP
5 mycobacterium chelonae 10.1 CD14 TLR2
6 mycobacterium kansasii 10.1 CD14 TLR2
7 urethritis 10.1 TLR1 TLR6
8 mesenteric lymphadenitis 10.1 MYD88 TLR2
9 mycobacterium abscessus 10.0 TLR1 TLR2
10 prosthetic joint infection 10.0 TLR2 TLR4
11 trench fever 10.0 TLR2 TLR4
12 fungal keratitis 10.0 TLR2 TLR4
13 acute cervicitis 10.0 TLR2 TLR4
14 ariboflavinosis 10.0 TLR4 TLR6
15 anterior uveitis 10.0 TLR2 TLR4
16 spondylarthropathy 9.9 TLR2 TLR4
17 neurosyphilis 9.9 TLR1 TLR2 TLR6
18 ocular toxoplasmosis 9.9 TLR1 TLR5
19 niemann-pick disease, type c2 9.9 LY96 TLR4
20 lyme disease 9.9 TLR1 TLR2 TLR6
21 myositis fibrosa 9.9 MYD88 TLR2 TLR4
22 paracoccidioidomycosis 9.9 MYD88 TLR2 TLR4
23 toxoplasmosis 9.9 MYD88 TLR2 TLR4
24 neisseria meningitidis infection 9.9 TLR2 TLR4
25 alveolar echinococcosis 9.9 CD36 TLR2 TLR4
26 septic arthritis 9.9 TLR2 TLR4
27 bacteriuria 9.8 TIRAP TLR1 TLR4
28 q fever 9.8 TLR1 TLR2 TLR4
29 scrub typhus 9.8 TLR2 TLR4
30 aortic aneurysm, familial abdominal, 1 9.8
31 alzheimer disease 9.8
32 anxiety 9.8
33 chlamydia 9.8
34 lymphadenitis 9.8
35 dermatitis 9.8
36 aortic aneurysm 9.8
37 syphilis 9.8
38 amyloidosis 9.8
39 legionnaires' disease 9.8 TLR4 TLR5 TLR6
40 mycobacterium tuberculosis 1 9.8 MYD88 TLR1 TLR2 TLR4
41 middle ear disease 9.8 TLR2 TLR4
42 penicilliosis 9.7 TLR1 TLR2 TLR4 TLR6
43 invasive aspergillosis 9.7 TLR1 TLR2 TLR4 TLR6
44 filariasis 9.7 TLR1 TLR2 TLR4 TLR6
45 suppurative otitis media 9.7 TLR2 TLR4 TLR5
46 ileitis 9.7 TLR2 TLR4 TLR5
47 pneumonia 9.7 TLR2 TLR4 TLR5
48 legionellosis 9.6 MYD88 TLR2 TLR4 TLR5
49 malaria 9.6 CD36 MYD88 TIRAP TLR2 TLR4
50 pelvic inflammatory disease 9.5 TIRAP TLR1 TLR2 TLR4 TLR6

Graphical network of the top 20 diseases related to Myd88 Deficiency:



Diseases related to Myd88 Deficiency
Sources

Symptoms & Phenotypes for Myd88 Deficiency

About this section

Clinical features from OMIM:

612260

Human phenotypes related to Myd88 Deficiency:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
2 immunodeficiency 59 32 hallmark (90%) Very frequent (99-80%) HP:0002721
3 recurrent bacterial skin infections 59 32 frequent (33%) Frequent (79-30%) HP:0005406

MGI Mouse Phenotypes related to Myd88 Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ACAA1 BTK CD14 CD36 IRAK4 LY96
2 cellular MP:0005384 9.92 BTK CD36 IRAK4 LY96 MYD88 TLR2
3 adipose tissue MP:0005375 9.85 CD14 CD36 MYD88 TLR2 TLR4 TLR5
4 digestive/alimentary MP:0005381 9.73 BTK CD36 MYD88 TLR2 TLR4 TLR5
5 homeostasis/metabolism MP:0005376 9.65 ACAA1 BTK CD14 CD36 IRAK4 MYD88
6 immune system MP:0005387 9.4 BTK CD14 CD36 IRAK4 LY96 MYD88
Sources

Drugs & Therapeutics for Myd88 Deficiency

About this section

Search Clinical Trials , NIH Clinical Center for Myd88 Deficiency

Sources

Genetic Tests for Myd88 Deficiency

About this section

Genetic tests related to Myd88 Deficiency:

# Genetic test Affiliating Genes
1 Myd88 Deficiency 29 MYD88
Sources

Anatomical Context for Myd88 Deficiency

About this section

MalaCards organs/tissues related to Myd88 Deficiency:

41
Myeloid, Skin, Kidney, Eye, Salivary Gland, Monocytes, Nk Cells
Sources

Publications for Myd88 Deficiency

About this section

Articles related to Myd88 Deficiency:

(show all 20)
# Title Authors Year
1
MyD88 Deficiency Protects Against Dry Eye-Induced Damage. ( 30025110 )
2018
2
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice. ( 30038386 )
2018
3
Targeted next-generation sequencing revealed MYD88 deficiency in a child with chronic yersiniosis and granulomatous lymphadenitis. ( 26632527 )
2016
4
Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus. ( 25954804 )
2015
5
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. ( 25788530 )
2015
6
MyD88 deficiency alters expression of antimicrobial factors in mouse salivary glands. ( 25415419 )
2014
7
MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. ( 23940747 )
2013
8
The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands. ( 23857504 )
2013
9
The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice. ( 22051943 )
2012
10
MyD88 deficiency results in both cognitive and motor impairments in mice. ( 22401992 )
2012
11
MyD88 deficiency ameliorates I^-amyloidosis in an animal model of Alzheimer's disease. ( 21763676 )
2011
12
MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolution. ( 21078858 )
2011
13
Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance. ( 21557220 )
2011
14
MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4. ( 21960563 )
2011
15
Myeloid differentiation primary response gene 88 (MyD88) deficiency in a large kindred. ( 20538326 )
2010
16
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. ( 21057262 )
2010
17
Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. ( 20824098 )
2010
18
Pyogenic bacterial infections in humans with MyD88 deficiency. ( 18669862 )
2008
19
MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi. ( 16495516 )
2006
20
MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks. ( 16552045 )
2006
Sources

Variations for Myd88 Deficiency

About this section

UniProtKB/Swiss-Prot genetic disease variations for Myd88 Deficiency:

75
# Symbol AA change Variation ID SNP ID
1 MYD88 p.Leu93Pro VAR_047953
2 MYD88 p.Arg196Cys VAR_047954

ClinVar genetic disease variations for Myd88 Deficiency:

6 (show all 29)
# Gene Variation Type Significance SNP ID Assembly Location
1 MYD88 MYD88, 3-BP DEL, 160GAG deletion Pathogenic
2 MYD88 NM_001172567.1(MYD88): c.625C> T (p.Arg209Cys) single nucleotide variant Pathogenic rs137853064 GRCh37 Chromosome 3, 38182001: 38182001
3 MYD88 NM_001172567.1(MYD88): c.625C> T (p.Arg209Cys) single nucleotide variant Pathogenic rs137853064 GRCh38 Chromosome 3, 38140510: 38140510
4 MYD88 NM_001172567.1(MYD88): c.317T> C (p.Leu106Pro) single nucleotide variant Pathogenic rs137853065 GRCh37 Chromosome 3, 38180469: 38180469
5 MYD88 NM_001172567.1(MYD88): c.317T> C (p.Leu106Pro) single nucleotide variant Pathogenic rs137853065 GRCh38 Chromosome 3, 38138978: 38138978
6 MYD88 NM_002468.4(MYD88): c.794T> C (p.Leu265Pro) single nucleotide variant Uncertain significance rs387907272 GRCh37 Chromosome 3, 38182641: 38182641
7 MYD88 NM_002468.4(MYD88): c.794T> C (p.Leu265Pro) single nucleotide variant Uncertain significance rs387907272 GRCh38 Chromosome 3, 38141150: 38141150
8 MYD88 NM_002468.4(MYD88): c.643A> C (p.Thr215Pro) single nucleotide variant Benign rs191826554 GRCh37 Chromosome 3, 38182019: 38182019
9 MYD88 NM_002468.4(MYD88): c.643A> C (p.Thr215Pro) single nucleotide variant Benign rs191826554 GRCh38 Chromosome 3, 38140528: 38140528
10 MYD88 NM_001172567.1(MYD88): c.16_34del19 (p.Ala6Profs) deletion Pathogenic GRCh37 Chromosome 3, 38180168: 38180186
11 MYD88 NM_001172567.1(MYD88): c.16_34del19 (p.Ala6Profs) deletion Pathogenic GRCh38 Chromosome 3, 38138677: 38138695
12 MYD88 NM_002468.4(MYD88): c.300C> T (p.Gly100=) single nucleotide variant Benign rs373382593 GRCh37 Chromosome 3, 38180452: 38180452
13 MYD88 NM_002468.4(MYD88): c.300C> T (p.Gly100=) single nucleotide variant Benign rs373382593 GRCh38 Chromosome 3, 38138961: 38138961
14 MYD88 NM_002468.4(MYD88): c.790C> T (p.Arg264Ter) single nucleotide variant Uncertain significance rs748659894 GRCh37 Chromosome 3, 38182637: 38182637
15 MYD88 NM_002468.4(MYD88): c.790C> T (p.Arg264Ter) single nucleotide variant Uncertain significance rs748659894 GRCh38 Chromosome 3, 38141146: 38141146
16 MYD88 NM_002468.4(MYD88): c.899C> T (p.Thr300Ile) single nucleotide variant Uncertain significance rs138284536 GRCh37 Chromosome 3, 38182746: 38182746
17 MYD88 NM_002468.4(MYD88): c.899C> T (p.Thr300Ile) single nucleotide variant Uncertain significance rs138284536 GRCh38 Chromosome 3, 38141255: 38141255
18 MYD88 NM_002468.4(MYD88): c.75C> G (p.Ala25=) single nucleotide variant Benign rs79867863 GRCh37 Chromosome 3, 38180227: 38180227
19 MYD88 NM_002468.4(MYD88): c.75C> G (p.Ala25=) single nucleotide variant Benign rs79867863 GRCh38 Chromosome 3, 38138736: 38138736
20 MYD88 NM_002468.4(MYD88): c.145T> C (p.Phe49Leu) single nucleotide variant Uncertain significance rs372072898 GRCh37 Chromosome 3, 38180297: 38180297
21 MYD88 NM_002468.4(MYD88): c.145T> C (p.Phe49Leu) single nucleotide variant Uncertain significance rs372072898 GRCh38 Chromosome 3, 38138806: 38138806
22 MYD88 NM_002468.4(MYD88): c.405G> T (p.Gln135His) single nucleotide variant Uncertain significance rs372319724 GRCh37 Chromosome 3, 38181392: 38181392
23 MYD88 NM_002468.4(MYD88): c.405G> T (p.Gln135His) single nucleotide variant Uncertain significance rs372319724 GRCh38 Chromosome 3, 38139901: 38139901
24 MYD88 NM_002468.4(MYD88): c.618G> A (p.Val206=) single nucleotide variant Benign rs144836346 GRCh37 Chromosome 3, 38181994: 38181994
25 MYD88 NM_002468.4(MYD88): c.618G> A (p.Val206=) single nucleotide variant Benign rs144836346 GRCh38 Chromosome 3, 38140503: 38140503
26 MYD88 NM_002468.4(MYD88): c.538T> C (p.Tyr180His) single nucleotide variant Uncertain significance rs186265242 GRCh37 Chromosome 3, 38181914: 38181914
27 MYD88 NM_002468.4(MYD88): c.538T> C (p.Tyr180His) single nucleotide variant Uncertain significance rs186265242 GRCh38 Chromosome 3, 38140423: 38140423
28 MYD88 NM_002468.4(MYD88): c.550G> A (p.Asp184Asn) single nucleotide variant Uncertain significance GRCh37 Chromosome 3, 38181926: 38181926
29 MYD88 NM_002468.4(MYD88): c.550G> A (p.Asp184Asn) single nucleotide variant Uncertain significance GRCh38 Chromosome 3, 38140435: 38140435
Sources

Expression for Myd88 Deficiency

About this section
Search GEO for disease gene expression data for Myd88 Deficiency.
Sources

Pathways for Myd88 Deficiency

About this section

Pathways related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.94 ACAA1 BTK CD14 CD36 IRAK4 LY96
2
HIV Life Cycle 66
Show member pathways
 13.67 BTK CD14 CD36 IRAK4 LY96 MYD88
3
Activated TLR4 signalling 66
Show member pathways
 13.54 BTK CD14 CD36 IRAK4 LY96 MYD88
4
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.44 BTK CD14 CD36 LY96 MYD88 TIRAP
5
Akt Signaling 64
Show member pathways
 13.41 BTK IRAK4 MYD88 TIRAP TLR1 TLR2
6
IL-2 Pathway 64
Show member pathways
 13.22 BTK CD14 IRAK4 MYD88 TLR1 TLR2
7
Human cytomegalovirus infection 37
Show member pathways
 12.98 IRAK4 MYD88 TIRAP TLR2 TLR4
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.96 BTK CD14 IRAK4 LY96 MYD88 TIRAP
9
NF-KappaB Family Pathway 64
Show member pathways
 12.75 IRAK4 MYD88 TLR1 TLR2 TLR4 TLR5
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.74 CD14 LY96 MYD88 TIRAP TLR4
11
Influenza A 37
Show member pathways
 12.69 IRAK4 MYD88 TLR2 TLR4
12
NF-kappaB Signaling 4
12.62 BTK IRAK4 MYD88 TLR1 TLR2 TLR6
13
TRAF Pathway 64
Show member pathways
 12.53 BTK CD14 IRAK4 LY96 MYD88 TIRAP
14
Development FGFR signaling pathway 22
Show member pathways
 12.51 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
15
Development Slit-Robo signaling 22
Show member pathways
 12.48 CD14 LY96 TLR4 TLR5
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.38 BTK CD14 CD36 IRAK4 LY96 MYD88
17
Toll Comparative Pathway 64
Show member pathways
 12.37 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
18
Toxoplasmosis 37
Show member pathways
 12.33 IRAK4 LY96 MYD88 TLR2 TLR4
19
IL-1 Family Signaling Pathways 65
Show member pathways
 12.3 IRAK4 MYD88 TIRAP TLR2 TLR5
20
Dimerization of procaspase-8 66
Show member pathways
 12.29 BTK CD14 LY96 TLR4
21
Epstein-Barr virus infection 37
12.29 BTK IRAK4 MYD88 TLR2
22
VEGF Pathway (Qiagen) 22
Show member pathways
 12.27 BTK CD14 IRAK4 LY96 MYD88 TIRAP
23
Colorectal Cancer Metastasis 64
12.26 TLR1 TLR2 TLR4 TLR5 TLR6
24
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.26 BTK IRAK4 MYD88 TLR1 TLR2 TLR4
25
Tuberculosis 37
12.26 CD14 IRAK4 MYD88 TIRAP TLR1 TLR2
26
Phagosome 37
12.22 CD14 CD36 TLR2 TLR4 TLR6
27
Th1 Differentiation Pathway 65
Show member pathways
 12.14 TLR1 TLR2 TLR4 TLR5 TLR6
28
MAPK Pathway 72
Show member pathways
 12.11 TLR1 TLR2 TLR4 TLR5 TLR6
29
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.1 CD14 CD36 LY96 TLR1 TLR2 TLR4
30
Antigen processing-Cross presentation 66
Show member pathways
 12.1 BTK CD14 CD36 LY96 MYD88 TIRAP
31
NF-kappa B signaling pathway 37
11.95 BTK CD14 IRAK4 LY96 MYD88 TIRAP
32
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.94 CD14 LY96 MYD88 TLR4
33
Phagocytosis of Microbes 64
11.92 TLR1 TLR2 TLR4 TLR5 TLR6
34
Salmonella infection (KEGG) 37
11.9 CD14 MYD88 TLR4 TLR5
35
Pertussis 37
11.87 CD14 IRAK4 LY96 MYD88 TIRAP TLR4
36
Amoebiasis 37
11.85 CD14 TLR2 TLR4
37
NF-kB (NFkB) Pathway 67
11.83 BTK CD14 IRAK4 LY96 MYD88 TLR4
38
Legionellosis 37
11.69 CD14 MYD88 TLR2 TLR4 TLR5
39
AGE/RAGE pathway 1
11.68 IRAK4 MYD88 TIRAP
40
Transcription_NF-kB signaling pathway 22
11.68 CD14 LY96 MYD88 TLR4
41
Malaria 37
11.63 CD36 MYD88 TLR2 TLR4
42
Bacterial infections in CF airways 22
Show member pathways
 11.54 CD14 IRAK4 LY96 MYD88 TIRAP TLR1
43
A-beta Pathways: Uptake and Degradation 65
11.41 CD14 CD36 LY96 TLR4
44
IL-10 Pathway 64
11.25 CD14 TLR4
45
IL1 and megakaryocytes in obesity 1
11.25 MYD88 TLR1 TLR2
46
IKK complex recruitment mediated by RIP1 66
11.23 CD14 LY96 TLR4
47
NTHi-Induced Signaling 64
11.02 MYD88 TLR2
48
MIF Action Through Endocytic Pathway 64
10.92 CD14 LY96 TLR4
Sources

GO Terms for Myd88 Deficiency

About this section

Cellular components related to Myd88 Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 BTK CD14 CD36 IRAK4 LY96 MYD88
2 endosome membrane GO:0010008 9.65 CD14 IRAK4 LY96 MYD88 TLR4
3 receptor complex GO:0043235 9.61 CD36 TLR4 TLR6
4 phagocytic vesicle membrane GO:0030670 9.58 TLR1 TLR2 TLR6
5 intrinsic component of plasma membrane GO:0031226 9.54 LY96 TLR2 TLR4
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.32 TLR1 TLR2
7 lipopolysaccharide receptor complex GO:0046696 9.13 CD14 LY96 TLR4
8 membrane raft GO:0045121 9.1 BTK CD14 CD36 TLR1 TLR2 TLR6

Biological processes related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.98 CD36 MYD88 TIRAP TLR2
2 apoptotic signaling pathway GO:0097190 9.95 BTK CD14 LY96 TLR4
3 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.95 BTK CD14 LY96 TLR4
4 positive regulation of interleukin-6 production GO:0032755 9.94 CD36 MYD88 TLR2 TLR4
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.93 BTK CD14 CD36 IRAK4 LY96 MYD88
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.92 CD14 LY96 MYD88 TLR2 TLR4
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 BTK CD36 IRAK4 MYD88 TIRAP TLR2
8 response to bacterium GO:0009617 9.91 CD14 CD36 TLR4
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 CD36 TLR4 TLR5 TLR6
10 positive regulation of interleukin-8 production GO:0032757 9.91 MYD88 TIRAP TLR2 TLR4 TLR5
11 positive regulation of JNK cascade GO:0046330 9.9 MYD88 TIRAP TLR4
12 cellular response to mechanical stimulus GO:0071260 9.9 MYD88 TLR4 TLR5
13 positive regulation of interleukin-12 production GO:0032735 9.9 CD36 TIRAP TLR2 TLR4
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 CD14 TLR2 TLR4
15 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.89 CD14 LY96 TLR4 TLR6
16 cellular response to amyloid-beta GO:1904646 9.87 CD36 TLR4 TLR6
17 necroptotic process GO:0070266 9.85 CD14 LY96 TLR4
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 MYD88 TLR4 TLR6
19 toll-like receptor 4 signaling pathway GO:0034142 9.85 CD14 LY96 TLR4
20 regulation of cytokine secretion GO:0050707 9.85 TLR1 TLR2 TLR4 TLR5 TLR6
21 negative regulation of growth of symbiont in host GO:0044130 9.84 CD36 MYD88 TIRAP
22 positive regulation of interleukin-8 secretion GO:2000484 9.84 CD14 TLR1 TLR2
23 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.84 CD36 MYD88 TLR4 TLR6
24 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.83 CD36 TLR4 TLR6
25 cell activation GO:0001775 9.83 TLR1 TLR2 TLR6
26 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.82 CD14 LY96 TLR4
27 interleukin-1 beta secretion GO:0050702 9.8 CD36 TLR4 TLR6
28 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.8 CD14 LY96 TLR4
29 cellular response to diacyl bacterial lipopeptide GO:0071726 9.8 CD14 CD36 TLR2 TLR6
30 positive regulation of tumor necrosis factor production GO:0032760 9.8 CD14 CD36 LY96 MYD88 TIRAP TLR2
31 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.79 TIRAP TLR1 TLR6
32 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.79 CD36 TLR4 TLR6
33 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.78 CD14 CD36 TLR2 TLR6
34 cellular response to lipoteichoic acid GO:0071223 9.77 CD14 CD36 TIRAP TLR2 TLR4
35 cellular response to bacterial lipopeptide GO:0071221 9.76 CD36 TIRAP TLR2
36 positive regulation of type I interferon production GO:0032481 9.75 CD14 MYD88
37 positive regulation of interferon-beta production GO:0032728 9.75 TLR2 TLR4
38 positive regulation of interleukin-10 production GO:0032733 9.75 TLR2 TLR4
39 positive regulation of chemokine production GO:0032722 9.75 TLR2 TLR4
40 cellular response to triacyl bacterial lipopeptide GO:0071727 9.75 CD14 TLR1 TLR2
41 microglial cell activation GO:0001774 9.74 TLR2 TLR6
42 response to fatty acid GO:0070542 9.74 CD36 TLR2
43 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TIRAP TLR6
44 positive regulation of macrophage activation GO:0043032 9.74 TLR4 TLR6
45 toll-like receptor 9 signaling pathway GO:0034162 9.74 IRAK4 MYD88
46 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
47 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.74 CD14 TLR1 TLR2
48 3'-UTR-mediated mRNA stabilization GO:0070935 9.73 MYD88 TIRAP
49 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
50 response to molecule of bacterial origin GO:0002237 9.73 CD14 TLR2

Molecular functions related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 BTK MYD88 TIRAP TLR1 TLR2 TLR4
2 protein heterodimerization activity GO:0046982 9.88 TIRAP TLR1 TLR2 TLR4 TLR6
3 signaling receptor activity GO:0038023 9.8 TLR1 TLR2 TLR4 TLR6
4 transmembrane signaling receptor activity GO:0004888 9.76 TLR1 TLR4 TLR5 TLR6
5 lipopolysaccharide binding GO:0001530 9.56 CD14 LY96 TLR2 TLR4
6 interleukin-1 receptor binding GO:0005149 9.54 IRAK4 MYD88 TLR5
7 Toll-like receptor binding GO:0035325 9.5 CD36 MYD88 TLR2
8 Toll-like receptor 4 binding GO:0035662 9.43 LY96 TIRAP
9 lipopolysaccharide receptor activity GO:0001875 9.33 LY96 TLR2 TLR4
10 Toll-like receptor 2 binding GO:0035663 9.13 TIRAP TLR1 TLR6
11 lipopeptide binding GO:0071723 8.92 CD14 TLR1 TLR2 TLR6
12 protein binding GO:0005515 10.29 ACAA1 BTK CD14 CD36 IRAK4 LY96
Sources

Sources for Myd88 Deficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....