MYD88D
MCID: MYD002
MIFTS: 50

Myd88 Deficiency (MYD88D)

Categories: Blood diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Myd88 Deficiency

MalaCards integrated aliases for Myd88 Deficiency:

Name: Myd88 Deficiency 56 52 25 73 29 6 39 71
Pyogenic Bacterial Infections, Recurrent, Due to Myd88 Deficiency 36 13
Bacterial Susceptibility Due to Tlr Signaling Pathway Deficiency 52 58
Pyogenic Bacterial Infections Due to Myd88 Deficiency 52 25
Myd88d 56 73

Characteristics:

Orphanet epidemiological data:

58
bacterial susceptibility due to tlr signaling pathway deficiency
Inheritance: Autosomal recessive; Age of onset: Childhood; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

OMIM 56 612260
KEGG 36 H00721
ICD10 via Orphanet 33 D84.8
UMLS via Orphanet 72 C2677092
Orphanet 58 ORPHA183713
MedGen 41 C2677092
SNOMED-CT via HPO 68 234532001 386661006 50177009
UMLS 71 C2677092

Summaries for Myd88 Deficiency

Genetics Home Reference : 25 MyD88 deficiency is an inherited disorder of the immune system (primary immunodeficiency). This primary immunodeficiency affects the innate immune response, which is the body's early, nonspecific response to foreign invaders (pathogens). MyD88 deficiency leads to abnormally frequent and severe infections by a subset of bacteria known as pyogenic bacteria. (Infection with pyogenic bacteria causes the production of pus.) However, affected individuals have normal resistance to other common bacteria, viruses, fungi, and parasites. The most common infections in MyD88 deficiency are caused by the Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. Most people with this condition have their first bacterial infection before age 2, and the infections can be life-threatening in infancy and childhood. Infections become less frequent by about age 10. Streptococcus pneumoniae Staphylococcus aureus Pseudomonas aeruginosa Children with MyD88 deficiency develop invasive bacterial infections, which can involve the blood (septicemia), the membrane covering the brain and spinal cord (meningitis), or the joints (leading to inflammation and arthritis). Invasive infections can also cause areas of tissue breakdown and pus production (abscesses) on internal organs. In addition, affected individuals can have localized infections of the ears, nose, or throat. Although fever is a common reaction to bacterial infections, many people with MyD88 deficiency do not at first develop a high fever in response to these infections, even if the infection is severe.

MalaCards based summary : Myd88 Deficiency, also known as pyogenic bacterial infections, recurrent, due to myd88 deficiency, is related to lyme disease and plague. An important gene associated with Myd88 Deficiency is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Apoptosis and Toll-like receptor signaling pathway. Affiliated tissues include myeloid, brain and spinal cord, and related phenotypes are immunodeficiency and recurrent bacterial skin infections

NIH Rare Diseases : 52 MYD88 deficiency is a rare primary immunodeficiency characterized by an increased susceptibility to certain types of bacterial infections . People affected by this condition generally have abnormally frequent and life-threatening infections caused by pyogenic bacteria (such as Streptococcus pneumoniae , Staphylococcus aureus , and Pseudomonas aeruginosa ). However, their immune response to other common bacteria, viruses , fungi, and parasites is normal. MYD88 deficiency is caused by changes (mutations ) in the MYD88 gene and is inherited in an autosomal recessive manner. Management is focused on the prevention and early treatment of infections with appropriate antibiotics .

KEGG : 36 Autosomal recessive MyD88 deficiency predisposes affected patients to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. The patients are resistant to other microbes.

UniProtKB/Swiss-Prot : 73 MYD88 deficiency: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.

Wikipedia : 74 Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the... more...

More information from OMIM: 612260

Related Diseases for Myd88 Deficiency

Diseases related to Myd88 Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 lyme disease 29.2 TLR6 TLR2 TLR1
2 plague 27.4 TLR6 TLR5 TLR4 TLR2 TLR1 MYD88
3 bacterial infectious disease 27.4 TLR5 TLR4 TLR2 TLR1 MYD88 IRAK4
4 invasive pneumococcal disease, recurrent isolated 10.2 TIRAP IRAK4
5 waldenstroem's macroglobulinemia 10.2 MYD88 BTK
6 cataract 30 10.2 MYD88 LY96
7 mycobacterium chelonae 10.2 TLR2 CD14
8 mycobacterium kansasii 10.1 TLR2 CD14
9 human monocytic ehrlichiosis 10.1 TLR2 MYD88
10 mycobacterium abscessus 10.0 TLR2 TLR1
11 prosthetic joint infection 9.9 TLR4 TLR2
12 toxic pneumonitis 9.9 TLR6 TLR4
13 fungal keratitis 9.9 TLR4 TLR2
14 neisseria meningitidis infection 9.9 TLR4 TLR2
15 spondylarthropathy 9.9 TLR4 TLR2
16 hereditary angioedema with normal c1inh 9.9 TLR4 TLR2
17 pneumonic plague 9.8 TLR4 TLR2
18 aortic aneurysm, familial abdominal, 1 9.8
19 alzheimer disease 9.8
20 ovarian cancer 9.8
21 dermatitis, atopic 9.8
22 chlamydia 9.8
23 lymphadenitis 9.8
24 aortic aneurysm 9.8
25 syphilis 9.8
26 eye disease 9.8
27 lung disease 9.8
28 amyloidosis 9.8
29 cytokine deficiency 9.8
30 ovarian epithelial cancer 9.8
31 dental pulp disease 9.8 TLR4 TLR2
32 bubonic plague 9.8 TLR4 TLR2
33 ocular toxoplasmosis 9.8 TLR5 TLR1
34 meningococcal meningitis 9.8 TLR4 TLR2
35 gastrointestinal tularemia 9.8 TLR4 TLR2 MYD88
36 tularemia 9.8 TLR4 TLR2 MYD88
37 pneumonic tularemia 9.8 TLR4 TLR2 MYD88
38 silo filler's disease 9.8 TLR4 TLR2 MYD88
39 listeriosis 9.7 TLR4 TLR2 MYD88
40 splenic disease 9.7 TLR4 TLR2 MYD88
41 paracoccidioidomycosis 9.7 TLR4 TLR2 MYD88
42 urethritis 9.7 TLR4 TLR2
43 neurosyphilis 9.7 TLR6 TLR2 TLR1
44 alveolar echinococcosis 9.7 TLR4 TLR2 CD36
45 platelet glycoprotein iv deficiency 9.7 TLR4 TLR2 CD36
46 hyper ige syndrome 9.7 TLR4 TLR2 IRAK4
47 leukemia, acute monocytic 9.7 TLR4 TLR2 CD14
48 cervicitis 9.7 TLR4 TLR2
49 peritonitis 9.7 TLR4 TLR2 CD14
50 glanders 9.6 TLR5 TLR4

Graphical network of the top 20 diseases related to Myd88 Deficiency:



Diseases related to Myd88 Deficiency

Symptoms & Phenotypes for Myd88 Deficiency

Human phenotypes related to Myd88 Deficiency:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 immunodeficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0002721
2 recurrent bacterial skin infections 58 31 frequent (33%) Frequent (79-30%) HP:0005406
3 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945

Clinical features from OMIM:

612260

MGI Mouse Phenotypes related to Myd88 Deficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 BTK CD14 CD36 IRAK4 LY96 MYD88
2 cellular MP:0005384 9.92 BTK CD36 IRAK4 LY96 MYD88 TLR2
3 adipose tissue MP:0005375 9.85 CD14 CD36 MYD88 TLR2 TLR4 TLR5
4 digestive/alimentary MP:0005381 9.73 BTK CD36 MYD88 TLR2 TLR4 TLR5
5 homeostasis/metabolism MP:0005376 9.61 BTK CD14 CD36 IRAK4 MYD88 TIRAP
6 immune system MP:0005387 9.4 BTK CD14 CD36 IRAK4 LY96 MYD88

Drugs & Therapeutics for Myd88 Deficiency

Search Clinical Trials , NIH Clinical Center for Myd88 Deficiency

Genetic Tests for Myd88 Deficiency

Genetic tests related to Myd88 Deficiency:

# Genetic test Affiliating Genes
1 Myd88 Deficiency 29 MYD88

Anatomical Context for Myd88 Deficiency

MalaCards organs/tissues related to Myd88 Deficiency:

40
Myeloid, Brain, Spinal Cord, Skin, Bone, T Cells, Liver

Publications for Myd88 Deficiency

Articles related to Myd88 Deficiency:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Pyogenic bacterial infections in humans with MyD88 deficiency. 56 61 6
18669862 2008
2
MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis. 61
30770929 2020
3
A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation. 61
31301515 2019
4
Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. 61
31065023 2019
5
ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells. 61
30979817 2019
6
Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile. 61
30802297 2019
7
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice. 61
30038386 2019
8
Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways. 61
30738832 2019
9
MyD88 controls airway epithelial Muc5ac expression during TLR activation conditions from agricultural organic dust exposure. 61
30358438 2019
10
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. 61
30650348 2019
11
Host MyD88 signaling protects against acute graft-versus-host disease after allogeneic bone marrow transplantation. 61
30317551 2019
12
First Case of Patient With Two Homozygous Mutations in MYD88 and CARD9 Genes Presenting With Pyogenic Bacterial Infections, Elevated IgE, and Persistent EBV Viremia. 61
30837984 2019
13
TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection. 61
31824484 2019
14
Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. 61
29568058 2018
15
MyD88 signaling causes autoimmune sialadenitis through formation of high endothelial venules and upregulation of LTβ receptor-mediated signaling. 61
30250175 2018
16
MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control. 61
30067739 2018
17
MyD88 Deficiency Protects Against Dry Eye-Induced Damage. 61
30025110 2018
18
Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis. 61
29622163 2018
19
B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. 61
29161093 2018
20
Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes. 61
29522531 2018
21
Hematopoietic MyD88 and IL-18 are essential for IFN-γ-dependent restriction of type A Francisella tularensis infection. 61
28951422 2017
22
Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers. 61
29118245 2017
23
Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. 61
28642279 2017
24
Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88. 61
28432355 2017
25
General, but not myeloid or type II lung epithelial cell, myeloid differentiation factor 88 deficiency abrogates house dust mite induced allergic lung inflammation. 61
27625307 2017
26
HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway. 61
27807045 2017
27
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. 61
27979975 2017
28
Short-term MyD88 inhibition ameliorates cardiac graft rejection and promotes donor-specific hyporesponsiveness of skin grafts in mice. 61
27125343 2016
29
Targeted next-generation sequencing revealed MYD88 deficiency in a child with chronic yersiniosis and granulomatous lymphadenitis. 61
26632527 2016
30
Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice. 61
26694221 2016
31
Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. 61
25788530 2015
32
Differential Effect of MyD88 Signal in Donor T Cells on Graft-versus-Leukemia Effect and Graft-versus-Host Disease after Experimental Allogeneic Stem Cell Transplantation. 61
26552489 2015
33
MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota. 61
26259586 2015
34
Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis. 61
26136579 2015
35
Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus. 61
25954804 2015
36
MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection. 61
25583527 2015
37
The importance of the Pseudomonas aeruginosa type III secretion system in epithelium traversal depends upon conditions of host susceptibility. 61
25667266 2015
38
MyD88 in macrophages is critical for abscess resolution in staphylococcal skin infection. 61
25681348 2015
39
Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells. 61
25125146 2015
40
A role for innate immunity in the development of hypertension. 61
25441337 2014
41
MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages. 61
25124962 2014
42
MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP/PS1 transgenic mice. 61
25174876 2014
43
B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers. 61
25252960 2014
44
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. 61
24650018 2014
45
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. 61
25186904 2014
46
TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. 61
25070848 2014
47
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. 61
25254554 2014
48
Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine. 61
25045815 2014
49
Invasive pneumococcal disease in children can reveal a primary immunodeficiency. 61
24759830 2014
50
Mesenchymal stem cells secrete immunologically active exosomes. 61
24367916 2014

Variations for Myd88 Deficiency

ClinVar genetic disease variations for Myd88 Deficiency:

6 (show all 24) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MYD88 NM_002468.5(MYD88):c.-24_-6deldeletion Pathogenic 469578 rs746651350 3:38180162-38180180 3:38138671-38138689
2 MYD88 NM_002468.5(MYD88):c.586C>T (p.Arg196Cys)SNV Pathogenic 7495 rs137853064 3:38182001-38182001 3:38140510-38140510
3 MYD88 NM_002468.5(MYD88):c.278T>C (p.Leu93Pro)SNV Pathogenic 7496 rs137853065 3:38180469-38180469 3:38138978-38138978
4 MYD88 NM_002468.5(MYD88):c.154_156GAG[1] (p.Glu53del)short repeat Pathogenic/Likely pathogenic 235259 rs878852993 3:38180344-38180346 3:38138853-38138855
5 MYD88 NM_002468.5(MYD88):c.755T>C (p.Leu252Pro)SNV Uncertain significance 37055 rs387907272 3:38182641-38182641 3:38141150-38141150
6 MYD88 NM_002468.5(MYD88):c.-9C>GSNV Uncertain significance 134869 rs587778544 3:38180183-38180183 3:38138692-38138692
7 MYD88 NM_002468.5(MYD88):c.751C>T (p.Arg251Ter)SNV Uncertain significance 537300 rs748659894 3:38182637-38182637 3:38141146-38141146
8 MYD88 NM_002468.5(MYD88):c.860C>T (p.Thr287Ile)SNV Uncertain significance 537302 rs138284536 3:38182746-38182746 3:38141255-38141255
9 MYD88 NM_002468.5(MYD88):c.434C>A (p.Ala145Glu)SNV Uncertain significance 846019 3:38181460-38181460 3:38139969-38139969
10 MYD88 NM_002468.5(MYD88):c.479G>A (p.Arg160His)SNV Uncertain significance 838237 3:38181894-38181894 3:38140403-38140403
11 MYD88 NM_002468.5(MYD88):c.106T>C (p.Phe36Leu)SNV Uncertain significance 537299 rs372072898 3:38180297-38180297 3:38138806-38138806
12 MYD88 NM_002468.5(MYD88):c.366G>T (p.Gln122His)SNV Uncertain significance 537301 rs372319724 3:38181392-38181392 3:38139901-38139901
13 MYD88 NM_002468.5(MYD88):c.499T>C (p.Tyr167His)SNV Uncertain significance 568203 rs186265242 3:38181914-38181914 3:38140423-38140423
14 MYD88 NM_002468.5(MYD88):c.511G>A (p.Asp171Asn)SNV Uncertain significance 574389 rs1559484615 3:38181926-38181926 3:38140435-38140435
15 MYD88 NM_002468.5(MYD88):c.113A>G (p.Asn38Ser)SNV Uncertain significance 639601 3:38180304-38180304 3:38138813-38138813
16 MYD88 NM_002468.5(MYD88):c.212C>T (p.Thr71Ile)SNV Uncertain significance 660526 3:38180403-38180403 3:38138912-38138912
17 MYD88 NM_002468.5(MYD88):c.754C>G (p.Leu252Val)SNV Uncertain significance 653936 3:38182640-38182640 3:38141149-38141149
18 MYD88 NM_002468.5(MYD88):c.66G>T (p.Leu22=)SNV Likely benign 748869 3:38180257-38180257 3:38138766-38138766
19 MYD88 NM_002468.5(MYD88):c.604A>C (p.Thr202Pro)SNV Benign 469579 rs191826554 3:38182019-38182019 3:38140528-38140528
20 MYD88 NM_002468.5(MYD88):c.36C>G (p.Ala12=)SNV Benign 537305 rs79867863 3:38180227-38180227 3:38138736-38138736
21 MYD88 NM_002468.5(MYD88):c.261C>T (p.Gly87=)SNV Benign 537304 rs373382593 3:38180452-38180452 3:38138961-38138961
22 MYD88 NM_002468.5(MYD88):c.270C>G (p.Leu90=)SNV Benign 709850 3:38180461-38180461 3:38138970-38138970
23 MYD88 NM_002468.5(MYD88):c.644+3T>CSNV Benign 719591 3:38182062-38182062 3:38140571-38140571
24 MYD88 NM_002468.5(MYD88):c.80T>C (p.Met27Thr)SNV Benign 134871 rs201871349 3:38180271-38180271 3:38138780-38138780

UniProtKB/Swiss-Prot genetic disease variations for Myd88 Deficiency:

73
# Symbol AA change Variation ID SNP ID
1 MYD88 p.Leu93Pro VAR_047953 rs137853065
2 MYD88 p.Arg196Cys VAR_047954 rs137853064

Expression for Myd88 Deficiency

Search GEO for disease gene expression data for Myd88 Deficiency.

Pathways for Myd88 Deficiency

Pathways related to Myd88 Deficiency according to KEGG:

36
# Name Kegg Source Accession
1 Apoptosis hsa04210
2 Toll-like receptor signaling pathway hsa04620

Pathways related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
2
Show member pathways
13.66 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
3
Show member pathways
13.56 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
4
Show member pathways
13.43 TLR6 TLR4 TLR2 TLR1 TIRAP MYD88
5
Show member pathways
13.41 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
6
Show member pathways
13.21 TLR6 TLR5 TLR4 TLR2 TLR1 MYD88
7
Show member pathways
13.03 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
8
Show member pathways
12.79 TLR4 TLR2 MYD88 IRAK4 BTK
9
Show member pathways
12.75 TLR6 TLR5 TLR4 TLR2 TLR1 MYD88
10
Show member pathways
12.66 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
11 12.62 TLR6 TLR2 TLR1 MYD88 IRAK4 BTK
12
Show member pathways
12.54 TLR4 TLR2 TIRAP MYD88
13
Show member pathways
12.4 TLR5 TLR4 LY96 CD14
14
Show member pathways
12.4 TLR6 TLR4 TLR2 TLR1 TIRAP MYD88
15
Show member pathways
12.38 TLR4 TIRAP MYD88 LY96 IRAK4 CD14
16 12.37 TLR5 TLR4 MYD88 CD14
17 12.34 TLR5 TLR4 TIRAP MYD88 IRAK4
18 12.34 TLR6 TLR5 TLR4 TLR2 TIRAP MYD88
19
Show member pathways
12.33 TLR4 TLR2 MYD88 LY96 IRAK4
20
Show member pathways
12.33 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
21
Show member pathways
12.29 TLR4 LY96 CD14 BTK
22 12.29 TLR6 TLR4 TLR2 TLR1 TIRAP MYD88
23
Show member pathways
12.27 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
24 12.26 TLR6 TLR5 TLR4 TLR2 TLR1
25
Show member pathways
12.24 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
26 12.22 TLR6 TLR4 TLR2 CD36 CD14
27 12.14 TLR4 MYD88 IRAK4
28
Show member pathways
12.12 TLR6 TLR5 TLR4 TLR2 TLR1
29
Show member pathways
12.04 TLR6 TLR5 TLR4 TLR2 TLR1
30 12.04 TLR4 TIRAP MYD88 LY96 IRAK4 CD14
31 12.01 TLR4 TIRAP MYD88 LY96 IRAK4 CD14
32
Show member pathways
11.96 TLR6 TLR5 TLR4 TLR2 TLR1
33 11.95 TLR4 MYD88 IRAK4
34
Show member pathways
11.94 TLR4 MYD88 LY96 CD14
35 11.92 TLR6 TLR5 TLR4 TLR2 TLR1
36 11.89 TLR4 TIRAP MYD88 LY96 IRAK4 CD14
37 11.88 TLR4 TLR2 CD14
38 11.71 TLR5 TLR4 TLR2 MYD88 CD14
39 11.68 TIRAP MYD88 IRAK4
40 11.68 TLR4 MYD88 LY96 CD14
41
Show member pathways
11.68 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
42 11.64 TLR4 TLR2 MYD88 CD36
43 11.43 TLR4 LY96 CD36 CD14
44 11.31 MYD88 IRAK4 CD14
45 11.25 TLR2 TLR1 MYD88
46 11.23 TLR4 LY96 CD14
47 11.14 MYD88 IRAK4
48 11.02 TLR2 MYD88
49 10.92 TLR4 LY96 CD14

GO Terms for Myd88 Deficiency

Cellular components related to Myd88 Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.93 TLR6 TLR5 TLR4 TLR2 TLR1 CD36
2 plasma membrane GO:0005886 9.93 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
3 Golgi apparatus GO:0005794 9.91 TLR6 TLR4 TLR2 TLR1 CD36 CD14
4 endosome membrane GO:0010008 9.65 TLR4 MYD88 LY96 IRAK4 CD14
5 phagocytic vesicle membrane GO:0030670 9.58 TLR6 TLR2 TLR1
6 intrinsic component of plasma membrane GO:0031226 9.54 TLR4 TLR2 LY96
7 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.32 TLR2 TLR1
8 lipopolysaccharide receptor complex GO:0046696 9.13 TLR4 LY96 CD14
9 membrane raft GO:0045121 9.1 TLR6 TLR2 TLR1 CD36 CD14 BTK

Biological processes related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
2 immune response GO:0006955 10.11 TLR6 TLR4 TLR2 TLR1 CD36
3 positive regulation of gene expression GO:0010628 10.11 TLR6 TLR4 TLR2 MYD88 CD36
4 inflammatory response GO:0006954 10.09 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
5 cell surface receptor signaling pathway GO:0007166 10.08 TIRAP MYD88 LY96 CD36 CD14
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.06 TLR6 TLR4 TIRAP MYD88 IRAK4 CD36
7 immune system process GO:0002376 10.06 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
8 cellular response to lipopolysaccharide GO:0071222 10.05 TLR5 TLR4 MYD88 LY96 CD36 CD14
9 response to lipopolysaccharide GO:0032496 10.03 TLR4 TLR2 TIRAP MYD88 LY96 CD14
10 defense response to bacterium GO:0042742 10.02 TLR6 TLR5 TLR4 MYD88
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.02 TLR6 TLR4 TLR2 TIRAP MYD88 CD36
12 defense response to Gram-positive bacterium GO:0050830 9.98 TLR2 TIRAP MYD88 CD36
13 apoptotic signaling pathway GO:0097190 9.95 TLR4 LY96 CD14 BTK
14 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TLR4 LY96 CD14 BTK
15 positive regulation of interleukin-6 production GO:0032755 9.94 TLR4 TLR2 MYD88 CD36
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.92 TLR6 TLR5 TLR4 CD36
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.92 TLR4 TLR2 MYD88 LY96 CD14
18 response to bacterium GO:0009617 9.91 TLR4 CD36 CD14
19 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.91 TLR6 TLR4 LY96 CD14
20 positive regulation of JNK cascade GO:0046330 9.9 TLR4 TIRAP MYD88
21 cellular response to mechanical stimulus GO:0071260 9.9 TLR5 TLR4 MYD88
22 phagocytosis GO:0006909 9.9 TLR4 MYD88 CD14
23 positive regulation of interleukin-12 production GO:0032735 9.9 TLR4 TLR2 TIRAP CD36
24 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TLR4 TLR2 CD14
25 positive regulation of interleukin-8 production GO:0032757 9.89 TLR5 TLR4 TLR2 TIRAP MYD88
26 cellular response to amyloid-beta GO:1904646 9.88 TLR6 TLR4 CD36
27 positive regulation of interleukin-8 secretion GO:2000484 9.87 TLR4 TLR2 TLR1 CD14
28 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 TLR6 TLR4 MYD88
29 necroptotic process GO:0070266 9.85 TLR4 LY96 CD14
30 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.85 TLR6 TLR4 MYD88 CD36
31 toll-like receptor signaling pathway GO:0002224 9.85 TLR6 TLR5 TLR4 TLR2 TLR1 MYD88
32 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.84 TLR4 LY96 CD14
33 toll-like receptor 4 signaling pathway GO:0034142 9.84 TLR4 LY96 CD14
34 regulation of cytokine secretion GO:0050707 9.84 TLR6 TLR5 TLR2 TLR1
35 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.83 TLR6 TLR1 TIRAP
36 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.83 TLR6 TLR4 CD36
37 cell activation GO:0001775 9.83 TLR6 TLR2 TLR1
38 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.81 TLR6 TLR4 CD36
39 cellular response to diacyl bacterial lipopeptide GO:0071726 9.81 TLR6 TLR2 CD36 CD14
40 interleukin-1 beta secretion GO:0050702 9.8 TLR6 TLR4 CD36
41 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.8 TLR4 LY96 CD14
42 cellular response to lipoteichoic acid GO:0071223 9.8 TLR4 TLR2 TIRAP CD36 CD14
43 positive regulation of tumor necrosis factor production GO:0032760 9.8 TLR4 TLR2 TIRAP MYD88 LY96 CD36
44 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.78 TLR2 TLR1 CD14
45 cellular response to triacyl bacterial lipopeptide GO:0071727 9.77 TLR2 TLR1 CD14
46 cellular response to bacterial lipopeptide GO:0071221 9.77 TLR6 TLR2 TLR1 TIRAP CD36
47 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.76 TLR6 TLR2 CD36 CD14
48 microglial cell activation GO:0001774 9.75 TLR6 TLR2
49 positive regulation of interferon-beta production GO:0032728 9.75 TLR4 TLR2
50 positive regulation of interleukin-10 production GO:0032733 9.75 TLR4 TLR2

Molecular functions related to Myd88 Deficiency according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.31 TLR6 TLR5 TLR4 TLR2 TLR1 TIRAP
2 identical protein binding GO:0042802 10.04 TLR6 TLR4 TLR2 TLR1 TIRAP MYD88
3 signaling receptor activity GO:0038023 9.88 TLR6 TLR5 TLR4 TLR2 TLR1
4 transmembrane signaling receptor activity GO:0004888 9.83 TLR6 TLR5 TLR4 TLR1
5 amyloid-beta binding GO:0001540 9.76 TLR6 TLR4 TLR2 CD36
6 lipopolysaccharide binding GO:0001530 9.67 TLR4 TLR2 LY96 CD14
7 interleukin-1 receptor binding GO:0005149 9.61 TLR5 MYD88 IRAK4
8 Toll-like receptor binding GO:0035325 9.58 TLR2 MYD88 CD36
9 Toll-like receptor 4 binding GO:0035662 9.51 TIRAP LY96
10 lipopolysaccharide receptor activity GO:0001875 9.5 TLR4 TLR2 LY96
11 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.46 TLR6 TLR4 TLR2 TLR1
12 Toll-like receptor 2 binding GO:0035663 9.43 TLR6 TLR1 TIRAP
13 NAD(P)+ nucleosidase activity GO:0050135 9.26 TLR6 TLR4 TLR2 TLR1
14 lipopeptide binding GO:0071723 8.92 TLR6 TLR2 TLR1 CD14

Sources for Myd88 Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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