Myelitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MYL001 MIFTS: 49	Myelitis Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Myelitis

MalaCards integrated aliases for Myelitis:

Name: Myelitis ¹² ⁷⁶ ⁵³ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:322

MeSH ⁴⁴ D009187

NCIt ⁵⁰ C26832

SNOMED-CT ⁶⁸ 41370002

UMLS ⁷³ C0026975

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Summaries for Myelitis

Disease Ontology : ¹² A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord.

MalaCards based summary : Myelitis is related to acute transverse myelitis and transverse myelitis. An important gene associated with Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Prednisone and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷⁶ Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the... more...

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Related Diseases for Myelitis

Diseases related to Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)

#	Related Disease	Score	Top Affiliating Genes
1	acute transverse myelitis	33.9	AQP4 IL6
2	transverse myelitis	32.9	APOH AQP4 IL17A IL6 MBP TNF
3	neuromyelitis optica	31.7	AQP4 HLA-DPB1 IL17A IL6 MBP MOG
4	systemic lupus erythematosus	31.6	APOH HLA-DPB1 IL17A IL6 TNF
5	acute disseminated encephalomyelitis	30.9	AQP4 MBP MOG
6	arteriovenous fistula	30.2	APOH IL6
7	pneumonia	30.1	CCL11 IL6 TNF
8	neuritis	30.0	AQP4 MBP MOG TNF
9	optic neuritis	30.0	AQP4 MBP MOG TNF
10	lyme disease	29.9	IL17A IL6 TNF
11	rubella	29.8	HLA-DPB1 MOG TNF
12	spondylitis	29.8	IL17A IL6 TNF
13	mixed connective tissue disease	29.7	APOH IL6 TNF
14	hematopoietic stem cell transplantation	29.7	IL6 TNF
15	spinal cord injury	29.7	AQP4 IL6 TNF
16	optic nerve disease	29.7	AQP4 MBP MOG
17	colitis	29.7	IL17A IL6 TNF
18	intracranial hypertension	29.6	APOH AQP4 TNF
19	connective tissue disease	29.6	APOH HLA-DPB1 IL6 TNF
20	multiple sclerosis	29.6	AQP4 IL17A IL6 MBP MOG TNF
21	rheumatoid arthritis	29.5	HLA-DPB1 IL17A IL6 TNF
22	dermatitis, atopic	29.4	CCL11 IL17A IL9 TNF
23	localized scleroderma	29.3	IL6 TNF
24	psoriatic arthritis	29.3	IL17A IL6 TNF
25	ulcerative colitis	29.3	IL17A IL6 TNF
26	internuclear ophthalmoplegia	29.3	AQP4 MBP MOG
27	peripheral nervous system disease	29.2	AQP4 IL6 MBP MOG TNF
28	stroke, ischemic	29.2	APOH AQP4 MBP
29	narcolepsy	29.2	AQP4 HLA-DPB1 MOG TNF
30	demyelinating disease	29.1	AQP4 IL17A MBP MOG TNF
31	malaria	28.9	CCL11 IL17A IL6 IL9 TNF
32	viral encephalitis	28.9	IL6 MBP MOG TNF
33	asthma	28.7	CCL11 HLA-DPB1 IL17A IL6 IL9 TNF
34	acute flaccid myelitis	12.6
35	idiopathic acute transverse myelitis	12.3
36	secondary acute transverse myelitis	12.2
37	radiation myelitis	12.2
38	foix-alajouanine syndrome	11.6
39	antiphospholipid syndrome	11.4
40	thyrotoxic periodic paralysis	11.0
41	lupus - neurological sequelae	11.0
42	paresthesia	11.0
43	encephalitis	10.9
44	stiff-person syndrome	10.6
45	meningoencephalitis	10.6
46	lupus erythematosus	10.6
47	myelopathy, htlv-1-associated	10.5
48	tropical spastic paraparesis	10.5
49	meningitis	10.4
50	hepatitis	10.3

Graphical network of the top 20 diseases related to Myelitis:

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Symptoms & Phenotypes for Myelitis

MGI Mouse Phenotypes related to Myelitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.56	AQP4 CCL11 IL17A IL6 IL9 MBP
2	immune system	MP:0005387	9.23	AQP4 CCL11 IL17A IL6 IL9 MBP

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Drugs & Therapeutics for Myelitis

Drugs for Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Mycophenolic acid

Approved

Phase 4

24280-93-1

446541

Mitoxantrone

Approved, Investigational

Phase 4

65271-80-9

4212

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 1,Phase 2

2921-57-5

Interferon beta-1a

Approved, Investigational

Phase 4,Phase 2

145258-61-3

6438354

Neomycin

Approved, Vet_approved

Phase 4

1404-04-2

8378

Phenol

Approved, Experimental

Phase 4

108-95-2

996

Zinc sulfate

Approved, Investigational

Phase 4,Not Applicable

7733-02-0

Zinc

Approved, Investigational

Phase 4,Not Applicable

7440-66-6

Edetic Acid

Approved, Vet_approved

Phase 4,Phase 3,Phase 2

62-33-9, 60-00-4

6049

Iron

Approved

Phase 4,Phase 3,Phase 2

7439-89-6

23925

Pentetic acid

Approved

Phase 4,Phase 3,Phase 2

67-43-6

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 1,Phase 2

2920-86-7

Antibodies, Blocking

Phase 4

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunoglobulins

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antibodies

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Vaccines

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 1,Phase 2

Hormones

Phase 4,Phase 3,Phase 1,Phase 2

Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2

Antibiotics, Antitubercular

Phase 4

Anti-Bacterial Agents

Phase 4

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 1,Phase 2

glucocorticoids

Phase 4,Phase 3,Phase 1,Phase 2

Antitubercular Agents

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 1,Phase 2

Topoisomerase Inhibitors

Phase 4,Phase 1,Phase 2

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 1,Phase 2

Analgesics

Phase 4

Autonomic Agents

Phase 4,Phase 3,Phase 1,Phase 2

Antiemetics

Phase 4,Phase 3,Phase 1,Phase 2

Prednisolone acetate

Phase 4,Phase 3,Phase 1,Phase 2

Neuroprotective Agents

Phase 4,Phase 3,Phase 1,Phase 2

Gastrointestinal Agents

Phase 4,Phase 3,Phase 1,Phase 2

Protective Agents

Phase 4,Phase 3,Phase 2,Phase 1

Methylprednisolone acetate

Phase 4,Phase 3,Phase 1,Phase 2

Interferon-beta

Phase 4,Phase 2

Antiviral Agents

Phase 4,Phase 2,Phase 3,Early Phase 1

Adjuvants, Immunologic

Phase 4,Phase 1,Phase 2

interferons

Phase 4,Phase 2

Polymyxin B

Phase 4

Polymyxins

Phase 4

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Phase 1

Heptavalent Pneumococcal Conjugate Vaccine

Phase 4,Phase 3,Phase 2

Micronutrients

Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 262)

#	Name	Status	NCT ID	Phase	Drugs
1	Immunogenicity of 1 or 2 Doses of bOPV in Chilean Infants Primed With IPV Vaccine	Unknown status	NCT01841671	Phase 4
2	Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients	Unknown status	NCT02809079	Phase 4	Mycophenolate mofetil;Prednisone
3	Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders	Unknown status	NCT02021825	Phase 4	Mitoxantrone
4	Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis	Completed	NCT00179478	Phase 4	interferon beta 1a 30 ug IM once weekly
5	A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease)	Completed	NCT00304291	Phase 4	Mitoxantrone
6	Oral Corticotherapy in Megadoses to Treat Multiple Sclerosis During Relapse	Completed	NCT00753792	Phase 4	methylprednisolone;methylprednisolone;Placebo
7	A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults	Completed	NCT01427309	Phase 4
8	Fractional Inactivated Poliovirus Vaccine Booster and Rotavirus Study	Completed	NCT02847026	Phase 4
9	Immunogenicity of Monovalent Type 2 Oral Poliovirus Vaccine	Completed	NCT02643368	Phase 4
10	A Study to Evaluate the Safety and Immunogenicity of Monovalent OPV2 in Children Aged 1 to 5 Years in Lithuania	Completed	NCT02582255	Phase 4
11	A Study to Evaluate Safety and Immunogenicity of tOPV in 1 to 5 Years and at 6 Weeks of Age	Completed	NCT02580201	Phase 4
12	Intestinal and Humoral Immunity of Sequential Polio Vaccination Schedules	Completed	NCT02412514	Phase 4
13	MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study	Completed	NCT03226119	Phase 4
14	Polio End-game Strategies - Poliovirus Type 2 Challenge Study	Completed	NCT02189811	Phase 4
15	Study of IMOVAX POLIO® Subcutaneous as a Booster Vaccine in Pre-school Age Children in Japan	Completed	NCT02005536	Phase 4
16	IPV Clinical Trial - The Gambia	Completed	NCT01847872	Phase 4	IPV IM Needle;IPV ID Needle;IPV IM Device;IPV ID Device
17	Safety and Immunogenicity of 1 or 2 Doses of IPV in Latin American Infants Primed With Bivalent OPV Vaccine	Completed	NCT01831050	Phase 4
18	IPV in Moderate to Severe Chronic Malnourished 9-12 Month Old Children in Karachi.	Completed	NCT01695798	Phase 4
19	Immunogenicity and Safety Study of Infanrix Hexa in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery	Completed	NCT02422264	Phase 4	Prevnar13
20	Zinc and/or Probiotic Supplementation of Rotavirus and Oral Polio Virus Vaccines	Completed	NCT01616693	Phase 4
21	Sequential Inactivated Poliomyelitis Vaccine Followed by Oral Poliomyelitis Vaccine Versus Oral Poliomyelitis Vaccine	Completed	NCT01475539	Phase 4
22	A Safety Study of IMOVAX Polio Vaccine in Selected Cities in China	Completed	NCT01278433	Phase 4
23	A Study of the Safety of IMOVAX Polio™ in China	Completed	NCT01244464	Phase 4
24	Study to Evaluate the Safety of Co-administration of GSK Biologicals' Poliorix and Infanrix in Healthy Children in Russia	Completed	NCT01094171	Phase 4
25	Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE	Completed	NCT01546909	Phase 4
26	Comparison of Immunogenicity and Reactogenicity of INFANRIX™ HEXA and HEXAVAC™ Vaccines as a Primary Vaccination Course	Completed	NCT01457547	Phase 4
27	Regulatory Post-Marketing Surveillance Study for TETRAXIM™	Completed	NCT01437423	Phase 4
28	Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™	Completed	NCT01358825	Phase 4
29	Immunogenicity and Safety of Booster Dose of BoostrixTM Polio Vaccine in Previously Boosted Adults	Completed	NCT01323959	Phase 4
30	Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age	Completed	NCT01031303	Phase 4
31	Immunogenicity and Safety of GSK Biologicals' Infanrix Hexa in Infants	Completed	NCT00753649	Phase 4
32	Safety and Immunogenicity of a Booster Dose of GSK Biological's Boostrix-Polio Vaccine	Completed	NCT00635128	Phase 4
33	Study of a New Formulation of DTPa-HBV-IPV/Hib Vaccine Administered as a Booster Dose to 18-23 Months Old Children	Completed	NCT00611559	Phase 4
34	Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine	Completed	NCT00514059	Phase 4	Boostrix polio
35	Assess the Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 & 18 Mths of Age, in Healthy Infants	Completed	NCT00325156	Phase 4
36	Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine	Completed	NCT00304265	Phase 4
37	Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand	Completed	NCT00255021	Phase 4
38	Monovalent Oral Poliovirus Vaccine Type 1 Intestinal and Humoral Immunity Study	Recruiting	NCT03722004	Phase 4
39	Duration of IPV Priming and Antibody Decay	Recruiting	NCT03202719	Phase 4
40	Comparison of Immunity Following IPV Versus fIPV: a Community Based Randomized Controlled Trial in Pakistan	Active, not recruiting	NCT03286803	Phase 4
41	Evaluation of Immunogenicity and Safety of a Booster Dose of Infanrix Hexa™ in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery	Active, not recruiting	NCT02853929	Phase 4
42	To Develop, Implement and Evaluate the Polio Demonstration Project Comprising of a Community Based Intervention Package for Polio Eradication in Pakistan	Active, not recruiting	NCT01908114	Phase 4
43	A Study of Immunogenicity and Seroconversion With Sabin IPV Schedules in China.	Enrolling by invitation	NCT03597919	Phase 4
44	Sero-conversion Study for a Two-dose Schedule of Sabin IPV in China	Enrolling by invitation	NCT03546634	Phase 4
45	Persistence of IPV Immunity	Not yet recruiting	NCT03723837	Phase 4
46	Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.	Withdrawn	NCT00037115	Phase 4	interferon beta 1a;methotrexate;methylprednisolone
47	Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone	Unknown status	NCT00004645	Phase 3
48	Randomized Clinical Trial to Evaluate Immunogenicity and Safety in Mexicans Newborns	Unknown status	NCT01870206	Phase 3
49	Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)	Unknown status	NCT01343355	Phase 2, Phase 3	Tamibarotene
50	Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801	Completed	NCT01604746	Phase 3

Search NIH Clinical Center for Myelitis

Cochrane evidence based reviews: myelitis

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Genetic Tests for Myelitis

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Anatomical Context for Myelitis

MalaCards organs/tissues related to Myelitis:

⁴¹

Spinal Cord, Brain, Lung, Bone, B Cells, T Cells, Bone Marrow

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Publications for Myelitis

Articles related to Myelitis:

(show top 50) (show all 1280)

#	Title	Authors	Year
1	Acute Transverse Myelitis in Children, Literature Review. ( 29696041 )	Tavasoli A....Tabrizi A.	2018
2	Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. ( 29482893 )	Messacar K....Dominguez S.R.	2018
3	Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation. ( 29773357 )	Simon T....Deiva K.	2018
4	The association between acute flaccid myelitis (AFM) and Enterovirus D68 (EV-D68) - what is the evidence for causation? ( 29386095 )	Dyda A....MacIntyre C.R.	2018
5	Encephalitis and transverse myelitis in dengue and chikungunya coinfection. ( 29972580 )	Farias L.A.B.G....Pires Neto R.D.J.	2018
6	Drainage of Cerebrospinal Fluid and Blood Pressure Augmentation as Rescue Therapies for Ischemic Myelitis After Bronchial Embolization: A Case Report. ( 29851658 )	LAcpine P.A....Boisvert P.	2018
7	Short-segment transverse myelitis lesions in a cohort of Latin American patients with neuromyelitis optica spectrum disorders. ( 29789706 )	Carnero Contentti E....Caride A.	2018
8	Myelitis due to Coccidioidomycosis in an Immunocompetent Patient. ( 29808132 )	Vaysman T....Liu A.	2018
9	Systemic Lupus Erythematosus Presenting as Longitudinally Extensive Transverse Myelitis and Nephritis: A Case Report. ( 29872583 )	Zahid A.S....Talib A.	2018
10	Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient: Case Report and Review of the Current Literature. ( 29372173 )	Moline H.L....Schleiss M.R.	2018
11	Acute myelitis of children with positive anti-GM1 antibody: Case series and literature review. ( 29768373 )	Wang Z....Cai X.T.	2018
12	Trident sign trumps Aquaporin-4-IgG ELISA in diagnostic value in a case of longitudinally extensive transverse myelitis. ( 29709797 )	Jolliffe E.A....Flanagan E.P.	2018
13	Two cases of sarcoidosis presenting as longitudinally extensive transverse myelitis. ( 29770929 )	Scott A.M....Kalish R.	2018
14	Autoimmune myelitis in a CLL patient undergoing treatment with ibrutinib. ( 29804266 )	Wanner D....Steurer M.	2018
15	Neurosyphilis as a Cause of Transverse Myelitis in a Teenage Girl. ( 29602529 )	Jo Yaphockun K.K....Wai S.	2018
16	Long-term outcomes of varicella zoster virus infection-related myelitis in 10 immunocompetent patients. ( 29957386 )	Wang X....Yu S.	2018
17	Evaluation of idiopathic transverse myelitis revealing specific myelopathy diagnoses. ( 29247071 )	Zalewski N.L....Keegan B.M.	2018
18	Paraneoplastic striatal encephalitis and myelitis associated with anti-CV2/CRMP-5 antibodies in a patient with small cell lung cancer. ( 29777943 )	Dericioglu N....Tan E.	2018
19	Frequency of Aquaporin-4 Immunoglobulin G in Longitudinally Extensive Transverse Myelitis With Antiphospholipid Antibodies. ( 29655487 )	Guerra H....Flanagan E.P.	2018
20	Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. ( 29294596 )	Ahn S.M....Yoo B.	2018
21	Radiation-Induced Myelitis: Initial and Follow-Up MRI and Clinical Features in Patients at a Single Tertiary Care Institution during 20 Years. ( 29773568 )	Khan M....Izbudak I.	2018
22	To start immune therapy or not? An unusual presentation of longitudinally extensive transverse myelitis with pyrexia. ( 29725838 )	Rounis E....Sen A.	2018
23	Necrotic-hemorrhagic myelitis: A rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. ( 29249379 )	Preziosa P....Filippi M.	2018
24	MOG-antibody demyelinating diseases: a case of post-partum severe rhombencephalitis and transverse myelitis. ( 29438836 )	Vecchio D....Cantello R.	2018
25	Myelitis and Polyradiculoneuropathy With Severe Pain: Unusual Neurological Manifestations as Presenting Symptoms of Brucellosis. ( 29953037 )	Marques I.B....Gil-Gouveia R.	2018
26	Guillain-BarrAc syndrome, transverse myelitis and infectious diseases. ( 29375121 )	RodrA-guez Y....Anaya J.M.	2018
27	Short transverse myelitis in Chinese patients with neuromyelitis optica spectrum disorders. ( 29499441 )	Hu H....Ye J.	2018
28	Hypereosinophilic atopic transverse myelitis. ( 29888734 )	Fasola F.A....Aworanti O.W.	2018
29	Familial monophasic acute transverse myelitis due to the pathogenic variant in <i>VPS37A</i>. ( 29473047 )		2018
30	Possible Combined Central and Peripheral Demyelination Presenting as Optic Neuritis, Cervical Myelitis, and Demyelinating Polyneuropathy with Marked Nerve Hypertrophy. ( 29540658 )		2018
31	Natural history of longitudinally extensive transverse myelitis in 35 Hispanic patients with systemic lupus erythematosus: good short-term functional outcome and paradoxical increase in long-term mortality. ( 29635997 )		2018
32	Longitudinally extensive transverse myelitis following dengue virus infection: A rare entity. ( 29536963 )		2018
33	CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells. ( 29406923 )		2018
34	Novel Glial Targets and Recurrent Longitudinally Extensive Transverse Myelitis. ( 29710213 )		2018
35	MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder. ( 29670575 )		2018
36	Cytomegalovirus associated longitudinally extensive transverse myelitis and acute hepatitis in an immunocompetent adult. ( 29396069 )		2018
37	MRI Features of Aquaporin-4 Antibody-Positive Longitudinally Extensive Transverse Myelitis: Insights into the Diagnosis of Neuromyelitis Optica Spectrum Disorders. ( 29449281 )		2018
38	Clinical Features of Acute Flaccid Myelitis Temporally Associated With an Enterovirus D68 Outbreak: Results of a Nationwide Survey of Acute Flaccid Paralysis in Japan, August-December 2015. ( 29028962 )		2018
39	Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. ( 29719742 )		2018
40	Reversible paraspinal muscle hyperintensity in anti-MOG antibody-associated transverse myelitis. ( 29114566 )		2018
41	Effects of electroacupuncture on bladder and bowel function in patients with transverse myelitis: a prospective observational study. ( 29909400 )		2018
42	Longitudinally Extensive Transverse Myelitis. ( 29862450 )		2018
43	Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. ( 30500056 )	Elrick MJ...Duggal P	2018
44	A neonatal mouse model of Enterovirus D68 infection induces both interstitial pneumonia and acute flaccid myelitis. ( 30503887 )	Sun S...Liang Z	2018
45	Acute flaccid myelitis. ( 30510047 )	Gill PJ...Yeh EA	2018
46	US CDC task force to investigate acute flaccid myelitis cases. ( 30527604 )	Devi S	2018
47	Anti-Myelin Oligodendrocyte Glycoprotein Antibody Associated With Gray Matter Predominant Transverse Myelitis Mimicking Acute Flaccid Myelitis: A Presentation of Two Cases. ( 30077551 )	Wang C...Greenberg B	2018
48	Acute flaccid myelitis-Clustering of polio-like illness in the tertiary care centre in Southern India. ( 30169722 )	Sarmast SN...Benakappa A	2018
49	Acute flaccid myelitis associated with enterovirus D68 infection: A case report. ( 30200066 )	Chen IJ...Lo CW	2018
50	Comparative quantitative clinical, neuroimaging, and functional profiles in children with acute flaccid myelitis at acute and convalescent stages of disease. ( 30225922 )	Gordon-Lipkin E...Pardo CA	2018

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Genes for Myelitis

Genes related to Myelitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AQP4	Aquaporin 4	Protein Coding	36.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19348177 19140826 18509235 (more) 19917985
2	MBP	Myelin Basic Protein	Protein Coding	21.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11086392 9436377
3	IL6	Interleukin 6	Protein Coding	21.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	21.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	APOH	Apolipoprotein H	Protein Coding	20.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL9	Interleukin 9	Protein Coding	20.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL17A	Interleukin 17A	Protein Coding	19.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	19.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	17.99	DISEASES inferred ¹⁵
10	VPS37A	VPS37A, ESCRT-I Subunit	Protein Coding	16.91	GeneCards inferred via : Variants (show sections)
11	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)

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Variations for Myelitis

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Expression for Myelitis

Search GEO for disease gene expression data for Myelitis.

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Pathways for Myelitis

Pathways related to Myelitis according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.11	CCL11 HLA-DPB1 IL17A IL6 IL9 TNF
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.08	CCL11 IL17A IL6 IL9 TNF
3	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.54	CCL11 HLA-DPB1 IL17A IL6 IL9 TNF
4	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.4	HLA-DPB1 IL17A IL6 TNF
5	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.2	IL17A IL6 IL9 TNF
6	Epstein-Barr virus infection ³⁷	12.11	HLA-DPB1 IL6 TNF
7	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.07	CCL11 IL17A IL6 TNF
8	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.06	IL17A IL6 IL9 TNF
9	Tuberculosis ³⁷	12.04	HLA-DPB1 IL6 TNF
10	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12	CCL11 IL6 TNF
11	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.99	AQP4 IL6 TNF
12	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.88	CCL11 IL17A IL6 IL9
13	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.87	IL17A IL6 TNF
14	Spinal Cord Injury ¹	11.78	AQP4 IL6 MBP TNF
15	Interleukin-4 and 13 signaling ⁶⁶	11.73	CCL11 IL17A IL6 TNF
16	Hematopoietic cell lineage ³⁷	11.7	HLA-DPB1 IL6 TNF
17	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.59	IL17A IL9 TNF
18	Rheumatoid arthritis ³⁷	11.51	HLA-DPB1 IL17A IL6 TNF
19	Lung fibrosis ¹	11.45	CCL11 IL6 TNF
20	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.31	CCL11 IL17A IL6 TNF
21	African trypanosomiasis ³⁷	11.19	IL6 TNF
22	IL-10 Pathway ⁶⁴	11.18	IL6 TNF
23	Antifolate resistance ³⁷	11.12	IL6 TNF
24	Cytokines and Inflammatory Response ¹	11.09	IL6 TNF
25	Transcription factor regulation in adipogenesis ¹	10.93	IL6 TNF
26	Overview of nanoparticle effects ¹	10.86	IL6 TNF
27	G-protein signaling_Rap2B regulation pathway ²²	10.76	CCL11 IL17A IL6 IL9 TNF
28	G-protein signaling_RhoB regulation pathway ²²	10.58	CCL11 IL17A IL6 IL9 TNF
29	Development and heterogeneity of the ILC family ¹	10.43	IL17A IL6 IL9 TNF

Sources

GO Terms for Myelitis

Cellular components related to Myelitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.46	APOH HLA-DPB1 MBP TNF
2	extracellular space	GO:0005615	9.43	APOH CCL11 IL17A IL6 IL9 TNF
3	external side of plasma membrane	GO:0009897	8.92	AQP4 IL17A MOG TNF

Biological processes related to Myelitis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.62	CCL11 IL17A IL6 TNF
2	regulation of signaling receptor activity	GO:0010469	9.55	CCL11 IL17A IL6 IL9 TNF
3	negative regulation of neurogenesis	GO:0050768	9.49	IL6 TNF
4	positive regulation of interleukin-6 secretion	GO:2000778	9.48	IL17A MBP
5	positive regulation of osteoclast differentiation	GO:0045672	9.46	IL17A TNF
6	positive regulation of chemokine production	GO:0032722	9.43	IL6 TNF
7	positive regulation of glial cell proliferation	GO:0060252	9.4	IL6 TNF
8	negative regulation of lipid storage	GO:0010888	9.37	IL6 TNF
9	inflammatory response	GO:0006954	9.35	CCL11 IL17A IL6 IL9 TNF
10	positive regulation of neuroinflammatory response	GO:0150078	9.26	IL6 TNF
11	immune response	GO:0006955	9.17	CCL11 HLA-DPB1 IL17A IL6 IL9 MBP

Molecular functions related to Myelitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.02	CCL11 IL17A IL6 IL9 TNF

Sources

Sources for Myelitis

¹ BioSystems

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia