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MCID: MYL001
MIFTS: 51

Myelitis

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Myelitis

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MalaCards integrated aliases for Myelitis:

Name: Myelitis 11 19 75 53 5 43 14 16 71 33
Spinal Cord Inflammation Nos 33
Radiculomyelitis Nos 33
Myeloradiculitis 33

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD11: 33


External Ids:

Disease Ontology 11 DOID:322
MeSH 43 D009187
NCIt 49 C26832
SNOMED-CT 68 192682002
ICD11 33 1993728609
UMLS 71 C0026975
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Summaries for Myelitis

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GARD: 19 An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence.

MalaCards based summary: Myelitis, also known as spinal cord inflammation nos, is related to schistosomiasis and radiculopathy. An important gene associated with Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mitoxantrone and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology: 11 A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord.

Wikipedia: 75 Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the... more...
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Related Diseases for Myelitis

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Diseases related to Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 617)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.3 TNF IL9 IL17A IL10
2 radiculopathy 30.2 IL6 IL17A IL10 CXCL8 CCL11
3 poliomyelitis 30.2 TNF IL6 IL10
4 cryptococcosis 30.2 TNF IL17A IL10
5 covid-19 30.1 TNF IL6 IL10 CXCL8
6 human cytomegalovirus infection 30.1 TNF IL6 IL17A IL10
7 inflammatory bowel disease 1 30.1 TNF IL6 IL17A IL10
8 arachnoiditis 30.1 TNF MBP AQP4
9 lymphadenitis 30.1 TNF IL6 IL10 CXCL8
10 hypereosinophilic syndrome 30.1 IL9 IL10 CXCL8 CCL11
11 encephalitis 30.0 TNF MOG IL6 IL10 CXCL8 AQP4
12 colitis 30.0 TNF IL6 IL17A IL10 CXCL8
13 viral encephalitis 30.0 TNF MOG MBP IL6 IL10 AMPH
14 chlamydia 30.0 TNF IL6 IL17A IL10 CXCL8
15 spondyloarthropathy 1 29.9 TNFRSF1A TNF IL6 IL17A IL10
16 ulcerative colitis 29.9 TNF IL6 IL17A IL10 CXCL8
17 meningitis 29.9 TNF MMP9 IL6 IL17A IL10 CXCL8
18 respiratory failure 29.8 TNF IL6 IL17A IL10 CXCL8 CCL11
19 common variable immunodeficiency 29.8 TNF IL6 IL10 CD27
20 acquired immunodeficiency syndrome 29.8 TNFRSF1A TNF MBP IL6 IL10 APOA1
21 guillain-barre syndrome 29.8 TNFRSF1A TNF MOG MBP IL17A
22 hydrocephalus 29.7 TNF MTHFR MBP IL10 AQP4
23 sarcoidosis 1 29.7 TNF IL9 IL6 IL17A IL10 CD27
24 meningoencephalitis 29.6 TNF MOG MBP IL6 IL10
25 vasculitis 29.6 TNF MEFV IL6 IL17A IL10 CXCL8
26 optic neuritis 29.6 TNF MOG MBP IL6 IL10 CXCL8
27 spinal cord disease 29.5 TNF MOG MBP IL6 IL10 AQP4
28 chickenpox 29.5 TNF MOG IL6 IL17A IL10 CD27
29 neuritis 29.4 TNF MOG MMP9 MBP IL6 IL10
30 transverse myelitis 29.4 TNF MOG MBP IL6 AQP4 APOH
31 immune deficiency disease 29.1 TNFRSF1A TNF MBP IL6 IL17A IL10
32 peripheral nervous system disease 28.9 TNF MOG MMP9 MBP IL6 IL17A
33 external pathological resorption 10.4 TNF IL6
34 physiological polycythemia 10.4 TNF IL6
35 contact blepharoconjunctivitis 10.4 CXCL8 CCL11
36 senile entropion 10.4 TNF CXCL8
37 infectious anterior uveitis 10.4 TNF IL17A
38 acute retinal necrosis syndrome 10.3 TNF IL6 IL10
39 acute necrotizing pancreatitis 10.3 TNF IL6 IL10
40 transient arthritis 10.3 TNF IL6 IL17A
41 plague 10.3 TNF IL6 IL10
42 skin sarcoidosis 10.3 TNF IL6 IL17A
43 acute pericementitis 10.3 IL6 CXCL8
44 chromium allergic contact dermatitis 10.3 IL17A IL10
45 angular cheilitis 10.3 TNF IL6 IL17A
46 taeniasis 10.3 TNF IL6 IL10
47 intermittent hydrarthrosis 10.3 TNFRSF1A MEFV
48 fuchs' heterochromic uveitis 10.3 IL6 IL10 CXCL8
49 aspiration pneumonitis 10.3 TNF IL6 CXCL8
50 tenosynovitis 10.3 TNF IL6 IL17A

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to Myelitis
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Symptoms & Phenotypes for Myelitis

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GenomeRNAi Phenotypes related to Myelitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 AMPH APOA1 APOH AQP4 CCL11 CD27
2 no effect GR00402-S-2 10.15 AMPH APOA1 APOH AQP4 CCL11 CD27

MGI Mouse Phenotypes related to Myelitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 APOA1 APOH AQP4 IL10 IL17A IL6
2 immune system MP:0005387 10.17 AQP4 CCL11 CD27 IL10 IL17A IL6
3 liver/biliary system MP:0005370 10.03 APOA1 IL10 IL17A IL6 MEFV MTHFR
4 digestive/alimentary MP:0005381 10.02 AQP4 IL10 IL17A IL6 IL9 ITGA2B
5 reproductive system MP:0005389 9.9 AMPH AQP4 IL10 IL6 ITGA2B MBP
6 respiratory system MP:0005388 9.86 AQP4 CCL11 IL10 IL17A IL6 MMP9
7 hematopoietic system MP:0005397 9.8 AQP4 CCL11 CD27 IL10 IL17A IL6
8 integument MP:0010771 9.32 APOA1 IL10 IL17A IL6 ITGA2B MEFV
Sources

Drugs & Therapeutics for Myelitis

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Drugs for Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 70476-82-3, 65271-80-9 4212
2 Analgesics Phase 4
3 Immunoglobulins Phase 3
4 Antibodies Phase 3
5 Immunoglobulins, Intravenous Phase 3
6 gamma-Globulins Phase 3
7 Rho(D) Immune Globulin Phase 3
8
Dalfampridine Approved Phase 2 504-24-5 1727
9
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
10 Potassium Channel Blockers Phase 2
11 Immunoglobulin G Phase 1, Phase 2
12 Pharmaceutical Solutions Phase 1, Phase 2
13
Rituximab Approved Phase 1 174722-31-7
14
Bevacizumab Approved, Investigational Phase 1 216974-75-3 135329020
15 Antineoplastic Agents, Immunological Phase 1
16 Antibodies, Monoclonal Phase 1
17 Angiogenesis Inhibitors Phase 1
18 Vaccines
19 Autoantibodies
20 Mitogens

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Controlled High-risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS10) Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
2 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease) Completed NCT00304291 Phase 4 Mitoxantrone
3 An Open Label Pilot Study of Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event: Comparison With CHAMPS Results. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
4 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
5 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin (IVIg) Versus Standard Therapy for the Treatment of Transverse Myelitis in Adults and Children Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
6 Double-Blind, Placebo-Controlled Crossover Trial on the Safety and Efficacy of Sustained-Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
7 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
8 A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Transverse Myelitis (TM) Not yet recruiting NCT03887273 Phase 1, Phase 2
9 A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
10 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab
11 Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Completed NCT02276963 Phase 1 Ublituximab
12 An Open-label Phase 1b Study of Avastin® (Bevacizumab) for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD). Completed NCT01777412 Phase 1 Bevacizumab
13 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
14 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Completed NCT03336762
15 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Completed NCT02144935
16 Evaluating the Effectiveness of a Serious Game to Enhance Self-Management Skills Among Adolescents and Young Adults With Spinal Cord Dysfunction Completed NCT02341950
17 Transverse Myelitis Related to SARS-CoV-2 Vaccines in Patients: an Observational and Retrospective Study Using the WHO's Pharmacovigilance Database Completed NCT05178264 SARS-CoV-2 vaccines
18 A Prospective Observational Study of Maintenance Plasma Exchange (PLEX) for Neuromyelitis Optica Spectrum Disorders (MultiPLEX Study) Completed NCT01500681
19 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
20 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
21 Home Based Tele-exercise for People With Chronic Neurological Impairments Recruiting NCT04564495
22 Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
23 Ultrasound Imaging Based Sensing to Predict Human Ankle Movement Intent and Assist-As-Needed Control Using Functional Electrical Stimulation and Powered Ankle Exoskeleton Recruiting NCT05249595
24 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952
25 Swiss Pediatric Inflammatory Bain Disease Cohort Study Recruiting NCT05017142
26 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367
27 CCRC: Serum Auto-Antibodies in Neurological Disease Enrolling by invitation NCT00704626
28 CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies Terminated NCT01440452

Search NIH Clinical Center for Myelitis

Cochrane evidence based reviews: myelitis

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Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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Organs/tissues related to Myelitis:

MalaCards : Spinal Cord, Brain, Bone Marrow, Medulla Oblongata, Lung, Bone, T Cells
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Publications for Myelitis

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Articles related to Myelitis:

(show top 50) (show all 5627)
# Title Authors PMID Year
1
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. 53 62
19917985 2009
2
Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. 53 62
19140826 2009
3
[A case of anti-AQP4 antibody-positive recurrent myelitis overlapped with autoimmune disorders including incomplete CREST syndrome revealed multiple discontinuous cord lesions]. 53 62
19348177 2009
4
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. 53 62
18509235 2008
5
Ascending myelitis in association with herpes simplex virus. A case report. 53 62
9436377 1997
6
Spinal Infections. 62
36404042 2023
7
Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update. 62
35170658 2023
8
Identification of an N-phenylsulfonyl-2-(piperazin-1-yl)methyl-benzonitrile derivative as Zika virus entry inhibitor. 62
36417826 2023
9
Acute Inflammatory Diseases of the Central Nervous System After SARS-CoV-2 Vaccination. 62
36411077 2023
10
Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder: From the National Multiple Sclerosis Society Case Conference Proceedings. 62
36270950 2023
11
18 F-Fluorodeoxy Glucose and 11 C-Methionine Accumulation in Demyelinating Lesions. 62
36398309 2022
12
Lethargy and quadraparesis as initial manifestations of covid-19 child: Case report. 62
36415678 2022
13
Antiaquaporin 4-Related Optic Neuritis and Myelitis Post-COVID-19 Infection. 62
34629397 2022
14
Complete bone fusion in failed back surgery syndrome using teriparatide in neurosyphilis: A case report. 62
36459850 2022
15
Myelitis with flaccid paralysis due to Japanese encephalitis: case report and review of the literature. 62
35396695 2022
16
Aquaporin-4 IgG neuromyelitis optica spectrum disorder onset after Covid-19 vaccination: Systematic review. 62
36332464 2022
17
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: Presentation and outcomes of adults at a single center. 62
36272183 2022
18
MOG antibody associated disease (MOGAD) presenting with extensive brain stem encephalitis: A case report. 62
36388768 2022
19
Longitudinally extensive transverse myelitis after Covid-19 vaccination: case report and review of literature. 62
35240927 2022
20
Transverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review. 62
36334503 2022
21
Transverse Myelitis Following SARS-CoV-2 Vaccination: A Pharmacoepidemiological Study in the World Health Organization's Database. 62
36054163 2022
22
Monkeypox encephalitis with transverse myelitis in a female patient. 62
36470282 2022
23
MOG-Specific T Cells Lead to Spontaneous EAE with Multilocular B Cell Infiltration in the GF-IL23 Model. 62
35239103 2022
24
Animal models of compression spinal cord injury. 62
36121155 2022
25
Combination Intravenous Immune Globulin (IVIG) and High Dose Steroids for Treatment of Immune-Related Myelitis in a Non-Small Cell Lung Cancer Patient Treated With Pembrolizumab and Palliative Radiation Treatment: A Case Report. 62
36153193 2022
26
FLAMES with Elevated Myelin Basic Protein Followed by Myelitis. 62
35527028 2022
27
Acute isolated orchalgia as the initial symptom in thoracic cord disorder: 2 case report and literature review. 62
35780053 2022
28
Toxocara myelitis in a young woman: You can't see the wood for the trees! 62
36376140 2022
29
Single and Multifraction Spine Stereotactic Body Radiation Therapy and the Risk of Radiation Induced Myelopathy. 62
36188436 2022
30
Myelin oligodendrocyte glycoprotein associated transverse myelitis following brain abscess: Case report and literature review. 62
36126373 2022
31
Changes of retinal structure and visual function in patients with demyelinating transverse myelitis. 62
35939134 2022
32
SARS-CoV-2 vaccinations complicated by transverse myelitis. 62
35417279 2022
33
MR imaging in children with transverse myelitis and acquired demyelinating syndromes. 62
35933757 2022
34
Neurologic Complications of Smallpox and Monkeypox: A Review. 62
36125794 2022
35
Temporal Dynamics of MOG Antibodies in Children With Acquired Demyelinating Syndrome. 62
36229191 2022
36
SLE-associated myelitis successfully treated by rituximab. 62
36419577 2022
37
Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: Onset Following Acute COVID-19 Infection, a Case Series. 62
36399224 2022
38
c-ANCA-associated vasculitis with predominant CNS demyelination after COVID-19. 62
36462988 2022
39
Glial fibrillary acidic protein as a biomarker in neuromyelitis optica spectrum disorder: a current review. 62
36378751 2022
40
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting as Intracranial Hypertension: A Case Report. 62
36261298 2022
41
Autoimmune glial fibrillar acidic protein astrocytopathy mimicking tuberculous meningitis. 62
36400717 2022
42
A disproportionality analysis for the association of central nervous system demyelinating diseases with COVID-19 vaccination using the World Health Organization pharmacovigilance database. 62
35822296 2022
43
MOGAD Involving Cranial Neuropathies: A Case Report and Review of Literature. 62
36421853 2022
44
Investigating paraneoplastic aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorder through a data-driven approach. 62
35767391 2022
45
Diagnosis of Neuromyelitis Optica Spectrum Disorder (NMOSD) and MOG Antibody-Associated Disease (MOGAD). 62
36410333 2022
46
Immune-mediated diseases involving central and peripheral nervous systems. 62
36366904 2022
47
COVID-19 vaccine associated transverse myelitis-Evusheld as an option when vaccination is not recommended due to severe adverse events. 62
35511579 2022
48
Re-Emergence of Poliovirus in the United States: Considerations and Implications. 62
36120838 2022
49
A Novel approach using O-CVP to treat paraneoplastic NMO spectrum disorder associated with follicular lymphoma. 62
36379621 2022
50
[Tick-Borne Encephalitis (TBE) - Clinical and Therapeutical Aspects]. 62
36303528 2022
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Variations for Myelitis

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ClinVar genetic disease variations for Myelitis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 COL6A2 NM_001849.4(COL6A2):c.2008A>G (p.Thr670Ala) SNV Uncertain Significance
 598977 rs753298014 GRCh37: 21:47545737-47545737
GRCh38: 21:46125823-46125823
2 CACNA1A NM_001127222.2(CACNA1A):c.6125C>T (p.Thr2042Met) SNV Uncertain Significance
 386521 rs563345694 GRCh37: 19:13323262-13323262
GRCh38: 19:13212448-13212448
Sources

Expression for Myelitis

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Search GEO for disease gene expression data for Myelitis.
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Pathways for Myelitis

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Pathways related to Myelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.95 TNFRSF1A TNF MMP9 MEFV IL9 IL6
2
ERK Signaling 64
Show member pathways
 13.82 TNFRSF1A TNF ITGA2B IL9 IL6 IL17A
3
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.6 CCL11 CD27 CXCL8 IL10 IL17A IL6
4
TGF-Beta Pathway 64
Show member pathways
 13.52 CCL11 CXCL8 IL10 IL17A IL6 IL9
5
Akt Signaling 64
Show member pathways
 13.37 TNFRSF1A TNF ITGA2B IL9 IL6 IL17A
6
PAK Pathway 64
Show member pathways
 13.26 TNFRSF1A TNF IL9 IL6 IL17A IL10
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.08 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
8
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.65 TNF IL9 IL6 IL17A IL10 CXCL8
9
Bacterial infections in CF airways 22
Show member pathways
 12.4 TNF IL6 CXCL8 CCL11
10
IL-17 Family Signaling Pathways 65
Show member pathways
 12.27 TNF MMP9 IL6 IL17A CXCL8
11
Colorectal Cancer Metastasis 64
12.2 IL6 MMP9 TNF TNFRSF1A
12
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.16 TNF IL6 IL10 CXCL8 AQP4
13
Neuroinflammation and glutamatergic signaling 74
12.12 TNFRSF1A TNF IL6 IL10
14
Hematopoietic Stem Cells and Lineage-specific Markers 65
12.01 TNF ITGA2B IL6 IL10
15
IL27-mediated signaling events 61
Show member pathways
 11.92 TNF IL6 IL17A IL10
16
Spinal cord injury 74
11.86 AQP4 CXCL8 IL6 MBP MMP9 TNF
17
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.85 IL6 IL17A CXCL8
18
Allograft rejection 74
11.84 CXCL8 HLA-DPB1 IL10 IL17A TNF
19
Innate Lymphoid Cells Differentiation 65
11.81 TNF IL9 IL17A IL10
20
Burn wound healing 74
11.77 TNF MMP9 IL6 CXCL8
21
Acute viral myocarditis 74
11.75 MMP9 IL6 IL10
22
Dendritic Cells Developmental Lineage Pathway 65
11.74 TNF IL6 IL10
23
Extrafollicular B cell activation by SARS-CoV-2 74
11.72 TNF IL6 IL10
24
AP-1 transcription factor network 61
11.72 MMP9 IL6 IL10 CXCL8
25
IL 10 signaling pathway 67
11.66 TNF IL6 IL10
26
miRNAs involvement in the immune response in sepsis 74
11.66 TNF IL6 IL10 CXCL8
27
Inflammatory bowel disease signaling 74
Show member pathways
 11.63 TNF IL6 IL10
28
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.63 TNFRSF1A TNF MMP9 IL6 CXCL8
29
Lung fibrosis 74
11.6 TNF MMP9 IL6 CXCL8 CCL11
30
SARS-CoV-2 innate immunity evasion and cell-specific immune response 74
11.57 TNF IL10 CXCL8
31
THC Differentiation Pathway 64
11.56 HLA-DPB1 IL10 TNF TNFRSF1A
32
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.56 CXCL8 IL6 TNF TNFRSF1A
33
Th2 Differentiation 65
11.52 IL9 IL10 CCL11
34
Nonalcoholic fatty liver disease 74
11.51 TNFRSF1A TNF IL6
35
Interleukin-10 signaling 66
11.44 TNFRSF1A TNF IL6 IL10 CXCL8
36
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
Show member pathways
 11.4 TNFRSF1A TNF IL10
37
Validated transcriptional targets of AP1 family members Fra1 and Fra2 61
11.38 MMP9 IL6 CXCL8
38
IL-10 Pathway 64
11.38 TNF IL6 IL10
39
Development and heterogeneity of the ILC family 74
11.32 TNF IL9 IL6 IL17A
40
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway 74
11.3 TNF IL6 CXCL8
41
Cytokines and inflammatory response 74
11.28 TNF IL6 IL10
42
amb2 Integrin signaling 61
11.27 TNF MMP9 IL6
43
Interleukin-4 and Interleukin-13 signaling 66
11.2 TNF MMP9 IL6 IL17A IL10 CXCL8
44
Overview of nanoparticle effects 74
11.07 TNF IL6 CXCL8
45
Prostaglandin signaling 74
11 TNF MMP9 IL6 IL17A CXCL8
46
G-protein signaling_Rap2B regulation pathway 22
10.96 TNF ITGA2B IL9 IL6 IL17A IL10
47
Nanoparticle triggered regulated necrosis 74
10.79 TNFRSF1A TNF
48
Immune infiltration in pancreatic cancer 74
10.79 TNF IL6 IL17A IL10 CXCL8
49
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
10.78 IL9 IL6
50
COVID-19 adverse outcome pathway 74
10.7 IL6 CXCL8
Sources

GO Terms for Myelitis

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Cellular components related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 10.03 TNF MOG ITGA2B IL17A CD27 AQP4
2 extracellular space GO:0005615 10 APOA1 APOH CCL11 CXCL8 IL10 IL17A
3 cell surface GO:0009986 9.97 TNFRSF1A TNF MBP ITGA2B HLA-DPB1 CD27
4 extracellular region GO:0005576 9.74 TNFRSF1A TNF MMP9 IL9 IL6 IL17A

Biological processes related to Myelitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 10.18 TNFRSF1A MEFV IL10 APOA1
2 positive regulation of interleukin-6 production GO:0032755 10.13 TNF MBP IL6 IL17A
3 response to activity GO:0014823 10.07 TNF IL6 IL10
4 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.06 TNF MMP9 IL10
5 cellular response to interleukin-1 GO:0071347 10.06 AQP4 CCL11 CXCL8 IL17A
6 negative regulation of interleukin-1 beta production GO:0032691 10.04 MEFV AQP4 APOA1
7 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.03 TNF IL6 IL10
8 response to radiation GO:0009314 10.01 AQP4 CCL11 TNF
9 positive regulation of interleukin-1 beta production GO:0032731 10.01 TNF MEFV IL6 IL17A
10 liver regeneration GO:0097421 9.99 TNF IL6 IL10
11 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.97 TNF IL6 IL17A
12 response to glucocorticoid GO:0051384 9.97 TNF IL6 IL10 AQP4
13 negative regulation of neurogenesis GO:0050768 9.95 TNF IL6 CCL11
14 inflammatory response GO:0006954 9.86 TNFRSF1A TNF MEFV IL9 IL6 IL17A
15 regulation of vascular endothelial growth factor production GO:0010574 9.85 IL6 AQP4
16 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.8 APOA1 IL10 MBP
17 chronic inflammatory response to antigenic stimulus GO:0002439 9.73 TNF IL10
18 negative regulation of cell adhesion molecule production GO:0060354 9.73 APOA1 AQP4 CXCL8
19 negative regulation of cytokine production involved in immune response GO:0002719 9.63 TNF IL10 APOA1
20 immune response GO:0006955 9.36 TNF MBP IL9 IL6 IL17A IL10

Molecular functions related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.4 TNF IL9 IL6 IL17A IL10 CXCL8
Sources

Sources for Myelitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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