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MCID: MYL001
MIFTS: 49

Myelitis

Categories: Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Myelitis

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MalaCards integrated aliases for Myelitis:

Name: Myelitis 12 73 20 54 6 44 15 17 70

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:322
MeSH 44 D009187
NCIt 50 C26832
SNOMED-CT 67 192682002
UMLS 70 C0026975
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Summaries for Myelitis

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Disease Ontology : 12 A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord.

MalaCards based summary : Myelitis is related to external pathological resorption and scorpion envenomation. An important gene associated with Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mitoxantrone and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 73 Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the... more...

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Related Diseases for Myelitis

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Diseases related to Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 611)
# Related Disease Score Top Affiliating Genes
1 external pathological resorption 10.5 TNF IL6
2 scorpion envenomation 10.4 TNF IL6
3 physiological polycythemia 10.4 TNF IL6
4 punctate inner choroidopathy 10.4 TNF IL10
5 tropical endomyocardial fibrosis 10.4 TNF IL10
6 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
7 cardiogenic shock 10.4 TNF IL6
8 multifocal choroiditis 10.4 TNF IL10
9 chronic inflammatory demyelinating polyneuritis 10.4 TNF IL9 CCL11
10 miller fisher syndrome 10.4 TNF AQP4 AMPH
11 autoimmune inner ear disease 10.4 TNF MMP9
12 spotted fever rickettsiosis 10.4 TNF IL10
13 cerebritis 10.4 TNF AQP4 APOH
14 loiasis 10.3 IL9 IL10 CCL11
15 idiopathic anterior uveitis 10.3 TNF IL6 CXCL8
16 aortitis 10.3 TNF IL6 IL17A
17 streptococcal toxic-shock syndrome 10.3 TNF IL6 CXCL8
18 chromium allergic contact dermatitis 10.3 IL17A IL10
19 eales disease 10.3 TNF IL6 IL10
20 giant papillary conjunctivitis 10.3 IL6 CXCL8 CCL11
21 papillary conjunctivitis 10.3 IL6 CXCL8 CCL11
22 fuchs' heterochromic uveitis 10.3 IL6 CXCL8
23 tracheitis 10.3 TNF IL6 CXCL8
24 beryllium disease 10.3 TNF HLA-DPB1
25 toxicodendron dermatitis 10.3 TNF CXCL8
26 anthracosis 10.3 TNF IL6 CXCL8
27 taeniasis 10.3 TNF IL6 IL10
28 african tick-bite fever 10.3 TNF IL6 IL10
29 epididymis disease 10.3 TNF IL6 IL10
30 null-cell leukemia 10.3 TNF IL6
31 peptic esophagitis 10.3 TNF IL6 CXCL8
32 neonatal stroke 10.3 MTHFR AQP4
33 idiopathic neutropenia 10.3 TNF IL6 IL10
34 orchitis 10.3 TNF IL6 IL10
35 irritant dermatitis 10.3 TNF IL6 CXCL8
36 acute gonococcal cervicitis 10.3 IL6 IL10 CXCL8
37 hand, foot and mouth disease 10.3 IL6 IL10 AQP4
38 bagassosis 10.3 TNF IL6 CXCL8
39 actinomycosis 10.3 TNF IL6 IL10
40 nickel allergic contact dermatitis 10.3 IL9 IL17A IL10
41 aspiration pneumonia 10.3 TNF IL6 IL17A
42 blood group, globoside system 10.3 TNF IL6 CXCL8
43 palladium allergic contact dermatitis 10.3 TNF IL17A IL10
44 pharyngitis 10.3 TNF IL6 CXCL8
45 sudden sensorineural hearing loss 10.3 MTHFR IL6
46 acute cervicitis 10.3 IL10 CXCL8
47 spinal cord infarction 10.3 MTHFR APOH
48 vitreous disease 10.3 TNF IL6 CXCL8
49 endophthalmitis 10.3 TNF IL6 CXCL8
50 meconium aspiration syndrome 10.3 TNF IL6 CXCL8

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to Myelitis
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Symptoms & Phenotypes for Myelitis

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MGI Mouse Phenotypes related to Myelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 AQP4 CCL11 CCR6 CD27 IL10 IL17A
2 digestive/alimentary MP:0005381 9.86 AQP4 IL10 IL17A IL6 IL9 MMP9
3 immune system MP:0005387 9.77 AQP4 CCL11 CCR6 CD27 IL10 IL17A
4 respiratory system MP:0005388 9.23 AQP4 CCL11 IL10 IL17A IL6 MMP9
Sources

Drugs & Therapeutics for Myelitis

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Drugs for Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2 Analgesics Phase 4
3 Antibodies Phase 3
4 Immunoglobulins Phase 3
5 gamma-Globulins Phase 3
6 Immunoglobulins, Intravenous Phase 3
7 Rho(D) Immune Globulin Phase 3
8
4-Aminopyridine Approved Phase 2 504-24-5 1727
9
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
10 Potassium Channel Blockers Phase 2
11 Pharmaceutical Solutions Phase 1, Phase 2
12 Immunoglobulin G Phase 1, Phase 2
13
rituximab Approved Phase 1 174722-31-7 10201696
14
Bevacizumab Approved, Investigational Phase 1 216974-75-3
15 Antineoplastic Agents, Immunological Phase 1
16 Angiogenesis Inhibitors Phase 1
17 Antibodies, Monoclonal Phase 1
18 Autoantibodies
19 Mitogens

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease) Completed NCT00304291 Phase 4 Mitoxantrone
2 Controlled High-risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS10) Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
3 An Open Label Pilot Study of Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event: Comparison With CHAMPS Results. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
4 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
5 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin (IVIg) Versus Standard Therapy for the Treatment of Transverse Myelitis in Adults and Children Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
6 Double-Blind, Placebo-Controlled Crossover Trial on the Safety and Efficacy of Sustained-Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
7 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
8 Home Based Tele-exercise for People With Chronic Neurological Impairments Recruiting NCT04564495 Phase 1, Phase 2
9 A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Transverse Myelitis (TM) Not yet recruiting NCT03887273 Phase 1, Phase 2
10 A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
11 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab
12 An Open-label Phase 1b Study of Avastin® (Bevacizumab) for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD). Completed NCT01777412 Phase 1 Bevacizumab
13 Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Completed NCT02276963 Phase 1 Ublituximab
14 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
15 Evaluating the Effectiveness of a Serious Game to Enhance Self-Management Skills Among Adolescents and Young Adults With Spinal Cord Dysfunction Completed NCT02341950
16 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Completed NCT03336762
17 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
18 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
19 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952
20 Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
21 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
22 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367
23 A Prospective Observational Study of Maintenance Plasma Exchange (PLEX) for Neuromyelitis Optica Spectrum Disorders (MultiPLEX Study) Active, not recruiting NCT01500681
24 CCRC: Serum Auto-Antibodies in Neurological Disease Enrolling by invitation NCT00704626
25 CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies Terminated NCT01440452

Search NIH Clinical Center for Myelitis

Cochrane evidence based reviews: myelitis

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Genetic Tests for Myelitis

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Anatomical Context for Myelitis

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MalaCards organs/tissues related to Myelitis:

40
Spinal Cord, Brain, Bone, Bone Marrow, Lung, Skin, Liver
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Publications for Myelitis

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Articles related to Myelitis:

(show top 50) (show all 4892)
# Title Authors PMID Year
1
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. 61 54
19917985 2009
2
Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. 61 54
19140826 2009
3
[A case of anti-AQP4 antibody-positive recurrent myelitis overlapped with autoimmune disorders including incomplete CREST syndrome revealed multiple discontinuous cord lesions]. 61 54
19348177 2009
4
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. 54 61
18509235 2008
5
Ascending myelitis in association with herpes simplex virus. A case report. 61 54
9436377 1997
6
Longitudinally Extensive Myelitis Associated With Immune Checkpoint Inhibitors. 61
33637598 2021
7
Prognostic factors for relapse and outcome in pediatric acute transverse myelitis. 61
33509615 2021
8
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders. 61
32755221 2021
9
Myelitis in inflammatory disorders associated with myelin oligodendrocyte glycoprotein antibody and aquaporin-4 antibody: A comparative study in Chinese Han patients. 61
33220172 2021
10
Regulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68. 61
33484748 2021
11
COVID-19, HHV6 and MOG antibody: A perfect storm. 61
33607505 2021
12
Acute transverse myelitis with Dysautonomia following SARS-CoV-2 infection: A case report and review of literature. 61
33640717 2021
13
Primary Central Nervous System Lymphoma Mimicking Longitudinally Extensive Transverse Myelitis. 61
33791064 2021
14
Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review. 61
33342552 2021
15
Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries. 61
33714126 2021
16
Acute paraplegia in patient with spinal dural arteriovenous fistula after lumbar puncture and steroid administration: A case report. 61
33770639 2021
17
The efficacy of therapeutic apheresis in patients with refractory neuromyelitis optica spectrum disorders: a single-center retrospective study. 61
33752428 2021
18
[Differential diagnostics of autoimmune inflammatory spinal cord diseases]. 61
33765163 2021
19
Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report. 61
33750325 2021
20
Estimating Baseline Incidence of Conditions Potentially Associated with Vaccine Adverse Events: a Call for Surveillance System Using the Korean National Health Insurance Claims Data. 61
33686812 2021
21
Sciatic-to-Femoral Nerve End-to-End Coaptation for Proximal Lower Extremity Function in Patients With Acute Flaccid Myelitis: Technical Note and Review of the Literature. 61
33733670 2021
22
Characteristics of Upper Extremity Recovery in Acute Flaccid Myelitis: A Case Series. 61
33009334 2021
23
Discussion: Characteristics of Upper Extremity Recovery in Acute Flaccid Myelitis: A Case Series. 61
33620932 2021
24
Wallerian degeneration as a mimic of recurrence of myelitis. 61
33737387 2021
25
Outbreak of Enterovirus Infection with Neurological Presentations in a Pediatric Population in Northern Spain: A Clinical Observational Study. 61
33657631 2021
26
Delayed diagnosis of myelitis in a patient with Vogt-Koyanagi-Harada disease: a case report. 61
33788652 2021
27
Three-Year Longitudinal Motor Function and Disability Level of Acute Flaccid Myelitis. 61
33388543 2021
28
Varicella zoster virus infection in neurological patients in Bulgaria. 61
33661458 2021
29
Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. 61
33078247 2021
30
Myelin oligodendrocyte glycoprotein antibody-associated disorders: clinical spectrum, diagnostic evaluation, and treatment options. 61
32403899 2021
31
Spinal infarcts. 61
33775442 2021
32
Post-COVID-19 encephalomyelitis. 61
33722301 2021
33
Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report. 61
33743640 2021
34
Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database. 61
33423151 2021
35
Detect it so you can treat it: A case series and proposed checklist to detect neurotoxicity in checkpoint therapy. 61
33604462 2021
36
Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis. 61
33692131 2021
37
A case of longitudinally extensive transverse myelitis in an 80-year-old patient with systemic lupus erythematous and anti-aquaporin 4 antibodies. 61
33812223 2021
38
Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project. 61
33462778 2021
39
Isolated myelitis in a patient with Behcet's disease during golimumab therapy. 61
33684832 2021
40
Early factors associated with later conversion to multiple sclerosis in patients presenting with isolated myelitis. 61
33687973 2021
41
Reversible Cerebral Vasculopathy, Transverse Myelitis, and Active Systemic Lupus Erythematosus in an Aquaporin-4 Antibody-Positive Patient. 61
33468561 2021
42
Non-Criteria Manifestations of Juvenile Antiphospholipid Syndrome. 61
33802787 2021
43
Neurologic Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review. 61
33653902 2021
44
Neurology of inflammatory bowel disease. 61
33810878 2021
45
Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study. 61
33338439 2021
46
Pediatric acute demyelinating syndromes: identification and management in the emergency department. 61
33617213 2021
47
Hiccups, severe vomiting and longitudinally extensive transverse myelitis in a patient with prostatic adenocarcinoma and Aquaporin-4 antibodies. 61
33498007 2021
48
Acute transverse myelitis attributed to SARS-CoV-2 infection presenting as impaired mobility: a case report. 61
33646523 2021
49
Acute transverse myelitis after SARS-CoV-2 infection: a rare complicated case of rapid onset paraplegia. 61
33650074 2021
50
Spinal cord involvement in COVID-19: A review. 61
33705268 2021
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Variations for Myelitis

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ClinVar genetic disease variations for Myelitis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CACNA1A NM_001127222.2(CACNA1A):c.6125C>T (p.Thr2042Met) SNV Uncertain significance 386521 rs563345694 GRCh37: 19:13323262-13323262
GRCh38: 19:13212448-13212448
2 COL6A2 NM_001849.3(COL6A2):c.2008A>G (p.Thr670Ala) SNV Uncertain significance 598977 rs753298014 GRCh37: 21:47545737-47545737
GRCh38: 21:46125823-46125823
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Expression for Myelitis

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Search GEO for disease gene expression data for Myelitis.
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Pathways for Myelitis

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Pathways related to Myelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.02 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
2
ERK Signaling 63
Show member pathways
 13.83 TNFRSF1A TNF IL9 IL6 IL17A IL10
3
PEDF Induced Signaling 63
Show member pathways
 13.67 TNFRSF1A TNF IL9 IL6 IL17A IL10
4
TGF-Beta Pathway 63
Show member pathways
 13.55 TNFRSF1A TNF IL9 IL6 IL17A IL10
5
Akt Signaling 63
Show member pathways
 13.39 TNFRSF1A TNF IL9 IL6 IL17A IL10
6
PAK Pathway 63
Show member pathways
 13.24 TNFRSF1A TNF IL9 IL6 IL17A IL10
7
Cytokine Signaling in Immune system 65
Show member pathways
 13.22 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
8
Measles 36
Show member pathways
 12.82 TNFRSF1A TNF IL6 HLA-DPB1 CXCL8
9
Immune response NFAT in immune response 23
Show member pathways
 12.65 TNFRSF1A TNF IL10 ICOSLG HLA-DPB1
10
T cell receptor signaling pathway 36
Show member pathways
 12.61 TNF IL9 IL6 IL17A IL10
11
Th17 cell differentiation 36
Show member pathways
 12.6 TNF IL6 IL17A IL10 HLA-DPB1
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.35 TNF MMP9 IL6 IL17A CXCL8 CCL11
13
Allograft rejection 1 36
Show member pathways
 12.35 TNF IL9 IL6 IL17A IL10 ICOSLG
14
Human T-cell leukemia virus 1 infection 36
12.34 TNFRSF1A TNF IL6 HLA-DPB1
15
Toxoplasmosis 36
Show member pathways
 12.28 TNFRSF1A TNF IL10 HLA-DPB1
16
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.27 TNF IL9 IL6 IL17A IL10 CXCL8
17
Tuberculosis 36
12.24 TNFRSF1A TNF IL6 IL10 HLA-DPB1
18
Colorectal Cancer Metastasis 63
12.21 TNFRSF1A TNF MMP9 IL6
19
Bacterial infections in CF airways 23
Show member pathways
 12.2 TNF IL6 CXCL8 CCL11
20
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 TNF IL6 IL10 CXCL8 AQP4
21
Yersinia infection 36
12.1 TNF IL6 IL10 CXCL8
22
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.03 TNFRSF1A TNF IL6 IL10 CXCL8 CCR6
23
TNF signaling pathway 36
11.98 TNFRSF1A TNF MMP9 IL6
24
Amoebiasis 36
11.93 TNF IL6 IL10 CXCL8
25
Rheumatoid arthritis 36
11.88 TNF IL6 IL17A HLA-DPB1 CXCL8
26
Spinal Cord Injury 1
11.81 TNF MMP9 MBP IL6 CXCL8 AQP4
27
TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.8 TNFRSF1A TNF CD27
28
Innate Lymphoid Cell Differentiation Pathways 64
11.8 TNF IL9 IL17A IL10 CCR6
29
Th1 Differentiation Pathway 64
Show member pathways
 11.79 TNF IL6 IL17A IL10
30
Pertussis 36
11.78 TNF IL6 IL10 CXCL8
31
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF IL6 IL10
32
LPA receptor mediated events 1
11.69 MMP9 IL6 CXCL8
33
IgA-Producing B Cells in the Intestine 64
11.67 TNF IL6 IL10 ICOSLG CCR6
34
Legionellosis 36
11.63 TNF IL6 CXCL8
35
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.63 TNFRSF1A TNF MMP9 IL6 CXCL8
36
Lung fibrosis 1
11.6 TNF MMP9 IL6 CXCL8 CCL11
37
Photodynamic therapy-induced AP-1 survival signaling. 1
11.57 TNFRSF1A TNF IL6
38
Malaria 36
11.56 TNF IL6 IL10 CXCL8
39
amb2 Integrin signaling 1
11.54 TNF MMP9 IL6
40
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.53 IL6 CXCL8 CCL11
41
Th2 Differentiation Pathway 64
11.51 IL9 IL10 CCL11
42
African trypanosomiasis 36
11.41 TNF IL6 IL10
43
Interleukin-10 signaling 65
11.41 TNFRSF1A TNF IL6 IL10 CXCL8
44
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.39 TNFRSF1A TNF IL10
45
IL-10 Pathway 63
11.37 TNF IL6 IL10
46
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.35 MMP9 IL6 CXCL8
47
Development and heterogeneity of the ILC family 1
11.33 TNF IL9 IL6 IL17A
48
Antifolate resistance 36
11.31 TNF MTHFR IL6
49
Cytokines and Inflammatory Response 1
11.28 TNF IL6 IL10
50
Interleukin-4 and 13 signaling 65
11.22 TNF MMP9 IL6 IL17A IL10 CXCL8
Sources

GO Terms for Myelitis

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Cellular components related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
2 extracellular region GO:0005576 9.73 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
3 cell surface GO:0009986 9.7 TNFRSF1A TNF MBP HLA-DPB1 CD27 CCR6
4 external side of plasma membrane GO:0009897 9.17 TNF MOG IL17A ICOSLG CD27 CCR6

Biological processes related to Myelitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cellular response to interleukin-1 GO:0071347 9.8 IL17A CXCL8 CCL11
2 chemokine-mediated signaling pathway GO:0070098 9.77 CXCL8 CCR6 CCL11
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TNFRSF1A TNF IL6
4 cellular response to lipopolysaccharide GO:0071222 9.76 TNF IL6 IL10 CXCL8
5 response to glucocorticoid GO:0051384 9.74 TNF IL6 IL10
6 defense response GO:0006952 9.73 TNFRSF1A TNF ICOSLG CXCL8
7 humoral immune response GO:0006959 9.7 TNF IL6 CCR6
8 inflammatory response GO:0006954 9.7 TNFRSF1A TNF IL9 IL6 IL17A CXCL8
9 positive regulation of interleukin-1 beta production GO:0032731 9.69 TNF IL6 IL17A
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.65 TNF MMP9 IL10
11 regulation of neuroinflammatory response GO:0150077 9.62 MMP9 IL6
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.62 MBP IL10
13 response to molecule of bacterial origin GO:0002237 9.61 IL10 CXCL8
14 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.61 TNF MBP
15 regulation of establishment of endothelial barrier GO:1903140 9.6 TNFRSF1A TNF
16 negative regulation of lipid storage GO:0010888 9.58 TNF IL6
17 positive regulation of JAK-STAT cascade GO:0046427 9.58 TNF IL6 IL10
18 endothelial cell apoptotic process GO:0072577 9.56 TNF IL10
19 positive regulation of interleukin-6 production GO:0032755 9.56 TNF MBP IL6 IL17A
20 cytokine-mediated signaling pathway GO:0019221 9.56 TNFRSF1A TNF MMP9 IL6 IL17A IL10
21 death-inducing signaling complex assembly GO:0071550 9.55 TNFRSF1A TNF
22 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6
23 negative regulation of neurogenesis GO:0050768 9.54 TNF IL6 CCL11
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.5 TNF IL6 IL17A
25 negative regulation of cytokine production involved in immune response GO:0002719 9.49 TNF IL10
26 immune response GO:0006955 9.32 TNF MBP IL9 IL6 IL17A IL10

Molecular functions related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF IL9 IL6 IL17A IL10 CXCL8
Sources

Sources for Myelitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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