MCID: MYL001
MIFTS: 51

Myelitis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Myelitis

MalaCards integrated aliases for Myelitis:

Name: Myelitis 12 74 52 54 6 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:322
MeSH 43 D009187
NCIt 49 C26832
SNOMED-CT 67 41370002
UMLS 71 C0026975

Summaries for Myelitis

Disease Ontology : 12 A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord.

MalaCards based summary : Myelitis is related to external pathological resorption and scorpion envenomation. An important gene associated with Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mitoxantrone and rituximab have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the... more...

Related Diseases for Myelitis

Diseases related to Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 621)
# Related Disease Score Top Affiliating Genes
1 external pathological resorption 10.6 TNF IL6
2 scorpion envenomation 10.6 TNF IL6
3 punctate inner choroidopathy 10.6 TNF IL10
4 tropical endomyocardial fibrosis 10.5 TNF IL10
5 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
6 autoimmune inner ear disease 10.5 TNF MMP9
7 multifocal choroiditis 10.5 TNF IL10
8 neonatal stroke 10.5 MTHFR AQP4
9 spotted fever rickettsiosis 10.5 TNF IL10
10 idiopathic anterior uveitis 10.5 TNF IL6 CXCL8
11 streptococcal toxic-shock syndrome 10.5 TNF IL6 CXCL8
12 inflammatory bowel disease 25 10.4 TNF IL17A
13 eales disease 10.4 TNF IL6 IL10
14 plague 10.4 TNF IL6 IL10
15 papillary conjunctivitis 10.4 IL6 CXCL8 CCL11
16 giant papillary conjunctivitis 10.4 IL6 CXCL8 CCL11
17 peptic esophagitis 10.4 TNF IL6 CXCL8
18 irritant dermatitis 10.4 TNF IL6 CXCL8
19 beryllium disease 10.4 TNF HLA-DPB1
20 spinal cord infarction 10.4 MTHFR APOH
21 palladium allergic contact dermatitis 10.4 TNF IL17A IL10
22 cardiomyopathy, familial hypertrophic, 20 10.4 TNF IL6 CXCL8
23 cervicitis 10.4 TNF IL6 CXCL8
24 metal allergy 10.4 TNF IL17A IL10
25 blood group, globoside system 10.4 TNF IL6 CXCL8
26 vitreous disease 10.4 TNF IL6 CXCL8
27 burning mouth syndrome 10.4 TNF IL6 CXCL8
28 meconium aspiration syndrome 10.4 TNF IL6 CXCL8
29 juvenile arthritis 10.4 IL6 IL10 CXCL8
30 macular retinal edema 10.4 TNF IL6 CXCL8
31 endophthalmitis 10.4 TNF IL6 CXCL8
32 pneumonic plague 10.4 TNF IL17A IL10
33 systemic autoimmune disease 10.4 MMP9 IL6 IL17A
34 heart aneurysm 10.4 TNF MMP9 IL6
35 coronary aneurysm 10.4 TNF MMP9 IL6
36 thyroiditis 10.4 TNF IL6 IL10
37 erythema multiforme 10.4 TNF IL6 CXCL8
38 eosinophilic pneumonia 10.4 IL6 CXCL8 CCL11
39 endometritis 10.4 TNF IL6 CXCL8
40 neurosyphilis 10.4 IL17A IL10 CXCL8
41 acute generalized exanthematous pustulosis 10.4 IL17A CXCL8
42 ascaris lumbricoides infection 10.4 IL6 IL10 CXCL8
43 fuchs' heterochromic uveitis 10.4 IL6 CXCL8
44 apnea, obstructive sleep 10.4 TNF IL6 CXCL8
45 sudden sensorineural hearing loss 10.4 MTHFR IL6 APOH
46 decubitus ulcer 10.4 TNF MMP9 IL6
47 clonorchiasis 10.4 TNF IL10 CXCL8
48 lambert-eaton myasthenic syndrome 10.4 TNF IL10 AMPH
49 neonatal jaundice 10.4 TNF IL6 IL10
50 septic arthritis 10.4 TNF IL6 CXCL8

Graphical network of the top 20 diseases related to Myelitis:



Diseases related to Myelitis

Symptoms & Phenotypes for Myelitis

GenomeRNAi Phenotypes related to Myelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CD40LG CXCL8 IL10 IL17A TNF TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 APOH CXCL8 IL10 IL17A TNF TNFRSF1A

MGI Mouse Phenotypes related to Myelitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 AQP4 CCL11 CCR6 CD27 CD40LG IL10
2 homeostasis/metabolism MP:0005376 10.13 APOH AQP4 CCR6 CD40LG IL10 IL17A
3 immune system MP:0005387 10.1 AQP4 CCL11 CCR6 CD27 CD40LG IL10
4 digestive/alimentary MP:0005381 10.01 AQP4 IL10 IL17A IL6 IL9 MMP9
5 nervous system MP:0003631 9.93 AMPH AQP4 CCR6 CD40LG IL10 IL6
6 respiratory system MP:0005388 9.56 AQP4 CCL11 IL10 IL17A IL6 MMP9
7 vision/eye MP:0005391 9.28 AQP4 IL10 IL6 MBP MMP9 MOG

Drugs & Therapeutics for Myelitis

Drugs for Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2
rituximab Approved Phase 4 174722-31-7 10201696
3 Analgesics Phase 4
4 Antineoplastic Agents, Immunological Phase 4
5
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
6
Ravulizumab Approved, Investigational Phase 3 1803171-55-2
7 Complement System Proteins Phase 3
8 Antibodies Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Rho(D) Immune Globulin Phase 3
11 gamma-Globulins Phase 3
12 Immunoglobulins Phase 3
13 Vaccines Phase 3
14
Mesna Approved, Investigational Phase 1, Phase 2 3375-50-6 598
15
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
16
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
17
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
18
4-Aminopyridine Approved Phase 1, Phase 2 504-24-5 1727
19
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
20 Antineoplastic Agents, Hormonal Phase 1, Phase 2
21 Antibodies, Monoclonal Phase 1, Phase 2
22 Immunoglobulin G Phase 2
23 Pharmaceutical Solutions Phase 1, Phase 2
24 Alkylating Agents Phase 1, Phase 2
25 Thymoglobulin Phase 1, Phase 2
26
Isophosphamide mustard Phase 1, Phase 2 0
27 polysaccharide-K Phase 1, Phase 2
28 Antilymphocyte Serum Phase 1, Phase 2
29 Narcotics Phase 2
30 Potassium Channel Blockers Phase 1, Phase 2
31 Fibrinolytic Agents Phase 2
32 Tissue Plasminogen Activator Phase 2
33 Plasminogen Phase 2
34
Bevacizumab Approved, Investigational Phase 1 216974-75-3
35 Angiogenesis Inhibitors Phase 1
36 Complement C1 Inactivator Proteins Phase 1
37 Complement C1 Inhibitor Protein Phase 1
38 Complement C1s Phase 1
39
Nicotine Approved 54-11-5 942 89594
40
Caffeine Approved 58-08-2 2519
41
Ethanol Approved 64-17-5 702
42
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
43 Autoantibodies
44 Vitamins
45 Calciferol
46 Mitogens

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
2 Controlled High-risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS10) Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
3 Rituximab at Low dosE for neuromyelitiS optiCa spectrUm disordEr (RESCUE): a Prospective, Multicenter, Open-label, Follow-up Clinical Trial Active, not recruiting NCT04256252 Phase 4 Rituximab
4 An Open Label Pilot Study of Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event: Comparison With CHAMPS Results. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
5 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
6 A Randomized, Double-Blind, Multicenter, Parallel-Group Comparative Phase III Study Evaluating the Efficacy and Safety of TAK-816 Compared With ActHIB in Healthy Infants Completed NCT01379846 Phase 3
7 Randomized Clinical Trial of Plasma Exchanges Versus Sham Plasma Exchanges in Disabling Multiple Sclerosis Acute Relapses Refractory to Steroid Treatment Completed NCT01442233 Phase 3
8 Comparison of Annual Relapse Rate, Expanded Disability Status Scale, and Side Effects Between Azathioprine and Rituximab in Patients With Neuromyelitis Optica Spectrum Disorders Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
9 A Phase III Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Infants and Children Completed NCT01569581 Phase 3
10 A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD) Recruiting NCT04201262 Phase 3
11 A Phase 2/3 Open-Label, Single-Arm Trial to Evaluate the Safety and Activity of Eculizumab in Pediatric Patients With Relapsing Neuromyelitis Optica Spectrum Disorder Recruiting NCT04155424 Phase 2, Phase 3 Eculizumab
12 A Phase III, Open-label, Extension Trial of ECU-NMO-301 to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Active, not recruiting NCT02003144 Phase 3
13 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin (IVIg) Versus Standard Therapy for the Treatment of Transverse Myelitis in Adults and Children Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
14 A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Terminated NCT01892345 Phase 3 Eculizumab;Placebo
15 Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica Unknown status NCT01364246 Phase 1, Phase 2
16 Efficacy of Dose Intensified Radiotherapy of Spinal Metastases of Solid Tumors by Dose Increased, Homogeneous Radiation of Vertebral Body and Simultaneous Application of Stereotactic Boost. Unknown status NCT01849510 Phase 2
17 Double-Blind, Placebo-Controlled Crossover Trial on the Safety and Efficacy of Sustained-Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
18 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
19 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
20 Prevention of Recurrent Symptomatic Urinary Tract Infections in Participants With Chronic Neurogenic Bladder Dysfunction: A Mixed Method Study Completed NCT02591901 Phase 2 Uro vaxom
21 An Open Label Study of the Effects of Eculizumab in Neuromyelitis Optica Completed NCT00904826 Phase 1, Phase 2 Eculizumab
22 Single-center, Open Label Trial of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active Neuromyelitis Optica Spectrum Disorders (NMOSD) Completed NCT03062579 Phase 1, Phase 2 Tocilizumab
23 Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease Completed NCT00787722 Phase 1, Phase 2 Cyclophosphamide;G-CSF;rATG;Mesna;Rituximab;Methylprednisolone
24 A Phase II Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Infants Completed NCT01512706 Phase 2
25 Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases Recruiting NCT04218617 Phase 2
26 A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Transverse Myelitis (TM) Not yet recruiting NCT03887273 Phase 1, Phase 2
27 A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma Not yet recruiting NCT04026568 Phase 1, Phase 2 4-Aminopyridine;Placebo oral tablet
28 Thrombolysis in Ischemic Spinal Cord Stroke Terminated NCT02242084 Phase 2 Intravenuse Alteplase
29 A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
30 An Open-label Phase 1b Study of Avastin® (Bevacizumab) for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD). Completed NCT01777412 Phase 1 Bevacizumab
31 Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Completed NCT02276963 Phase 1 Ublituximab
32 Phase 1b Study of C1-esterase Inhibitor (Cinryze) With Standard of Care for Acute Treatment of Neuromyelitis Optica Exacerbations Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
33 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab
34 A Phase I Clinical Trial for Inactivated Enterovirus Type 71 Vaccine (Human Diploid Cell, KMB-17 Cell) in Chinese Adults, Children and Infants Completed NCT01391494 Phase 1
35 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
36 Proposal for a Non-randomized, Patient Sponsored, Multi-center Study Studying the Impact and Safety of the Utilization of Culture Expanded Autologous, Adipose-derived Mesenchymal Stem Cells Deployed Via Intravenous Injection for the Treatment of Multiple Sclerosis Terminated NCT02326935 Phase 1
37 A Single Center Open Label Pilot Study of Alpha1-Antitrypsin: A Novel Treatment to Mitigate Neuromyelitis Optica Attacks Withdrawn NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
38 Evaluation of Macular and Retinal Nerve Fiber Layer Thickness Measurements for Detection of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Optical Coherence Tomography. Unknown status NCT01024985
39 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
40 The French Multiple Sclerosis Registry Unknown status NCT02889965
41 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Unknown status NCT03284801
42 Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis Completed NCT04301752
43 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
44 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
45 Neurovirus Emerging in the Americas Study (NEAS): Neurologic Manifestations of the Arbovirus Dengue, Chikungunya and Zika Infections in Colombia Completed NCT03206541
46 Evaluating the Effectiveness of a Serious Game to Enhance Self-Management Skills Among Adolescents and Young Adults With Spinal Cord Dysfunction Completed NCT02341950
47 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
48 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Recruiting NCT03336762
49 Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
50 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952

Search NIH Clinical Center for Myelitis

Cochrane evidence based reviews: myelitis

Genetic Tests for Myelitis

Anatomical Context for Myelitis

MalaCards organs/tissues related to Myelitis:

40
Spinal Cord, Brain, Lung, Bone, Bone Marrow, B Cells, T Cells

Publications for Myelitis

Articles related to Myelitis:

(show top 50) (show all 4521)
# Title Authors PMID Year
1
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. 61 54
19917985 2009
2
Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. 61 54
19140826 2009
3
[A case of anti-AQP4 antibody-positive recurrent myelitis overlapped with autoimmune disorders including incomplete CREST syndrome revealed multiple discontinuous cord lesions]. 61 54
19348177 2009
4
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. 54 61
18509235 2008
5
Ascending myelitis in association with herpes simplex virus. A case report. 61 54
9436377 1997
6
COVID-19-associated acute necrotizing myelitis. 61
32522767 2020
7
A comparative study on clinical characterizations between acute myelitis onset of neuromyelitis optica spectrum disease and idiopathic transverse myelitis. 61
32497470 2020
8
Pontine Tegmentum Lesions Accompanying Myelitis During an Enterovirus Outbreak: Differential Diagnosis and Outcome. 61
32507080 2020
9
Neurological manifestations and complications of COVID-19: A literature review. 61
32409215 2020
10
Encephalomyeloneuritis and arthritis after treatment with immune checkpoint inhibitors. 61
32461353 2020
11
Is Asian type MS an MS phenotype, an NMO spectrum disorder, or a MOG-IgG related disease? 61
32361664 2020
12
Diagnostic features of initial demyelinating events associated with serum MOG-IgG. 61
32442864 2020
13
AQP4-IgG may cause muscle damage in patients with neuromyelitis optica spectrum disorder. 61
32413837 2020
14
The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. 61
32464367 2020
15
Hepatitis E: an expanding epidemic with a range of complications. 61
32251845 2020
16
Clinical and MRI phenotypes of sarcoidosis-associated myelopathy. 61
32269072 2020
17
Preventing an Acute Flaccid Myelitis Epidemic in the Time of a Pandemic. 61
32511671 2020
18
Spinal arteriovenous fistula's often misdiagnosed as myelitis; can we stem the flow? 61
32386907 2020
19
Subacute transverse myelitis with optic symptoms in neuroborreliosis: a case report. 61
32534574 2020
20
Transcutaneous electrical nerve stimulation (TENS) in neuropathic bladder due to transverse myelitis. 61
32565032 2020
21
A Severe Case of Enterovirus A71 Acute Flaccid Myelitis With Encephalitis. 61
32535628 2020
22
[Successful early treatment with acyclovir and corticosteroids for acute myelitis associated with zoster sine herpete: a case report]. 61
32536667 2020
23
Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report. 61
32559701 2020
24
Acute infectious myelopathies. 61
32332224 2020
25
Imaging of Neuromyelitis Optica Spectrum Disorders. 61
32448488 2020
26
"NMDA receptor spectrum disorder" in the differential diagnosis of demyelinating disorders of the CNS: optic neuritis and myelitis. 61
32564271 2020
27
A case of MOG encephalomyelitis with T- cell lymphoma. 61
32155461 2020
28
Toxocariasis of the Nervous System. 61
31960218 2020
29
Polyneuritis cranialis and vasculopathy caused by varicella zoster virus without rash. 61
32524536 2020
30
Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases. 61
32443044 2020
31
MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation. 61
32055995 2020
32
A comparative evaluation of different NeuroMyelitis Optica Spectrum Disorder sets criteria. 61
32559008 2020
33
Diagnostic procedures in suspected attacks in patients with neuromyelitis optica spectrum disorders: Results of an international survey. 61
32179483 2020
34
The relationship between aquaporin-4 antibody status and visual tract integrity in neuromyelitis optica spectrum disorders: A visual evoked potential study. 61
32575026 2020
35
Aseptic meningitis as an atypical manifestation of neuromyelitis optica spectrum disorder flare. 61
32088653 2020
36
Young woman with Guillain-Barré syndrome and cervical transverse myelitis-A new GBS variant, not coincidence. 61
32577262 2020
37
Acute flaccid myelitis: An overview. 61
32453144 2020
38
Radiation recall myelitis following capecitabine: First case report. 61
32540712 2020
39
Foramen magnum arteriovenous fistula presenting as transverse myelitis. 61
32180167 2020
40
Development of broad-spectrum enterovirus antivirals based on quinoline scaffold. 61
32559580 2020
41
Biennial Upsurge and Molecular Epidemiology of Enterovirus D68 Infection in New York, United States, 2014-2018. 61
32493783 2020
42
Clinical characteristics, misdiagnosis and outcomes of patients with low-flow spinal arteriovenous fistulas. 61
32386730 2020
43
Neurosarcoidosis: Analysis of a series of 20 patients. 61
32564930 2020
44
Systemic lupus erythematosus with autoimmune neurological manifestations in a carrier of chronic granulomatous disease - a rare presentation. 61
32247876 2020
45
Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside. 61
32533450 2020
46
Spinal adhesive arachnoiditis mimicking sarcoid myelitis with nodular dural enhancement: A case report. 61
32535503 2020
47
Biotinidase deficiency in differential diagnosis of neuromyelitis optica spectrum disorder. 61
32559702 2020
48
A review of pathophysiology and neuropsychiatric manifestations of COVID-19. 61
32494854 2020
49
Clinical reasoning in feline spinal disease: which combination of clinical information is useful? 61
31251096 2020
50
Enterovirus D68 Antivirals: Past, Present, and Future. 61
32352280 2020

Variations for Myelitis

ClinVar genetic disease variations for Myelitis:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL6A2 NM_001849.3(COL6A2):c.2008A>G (p.Thr670Ala)SNV Uncertain significance 598977 rs753298014 21:47545737-47545737 21:46125823-46125823
2 CACNA1A NM_001127221.1(CACNA1A):c.6128C>T (p.Thr2043Met)SNV Uncertain significance 386521 rs563345694 19:13323262-13323262 19:13212448-13212448

Expression for Myelitis

Search GEO for disease gene expression data for Myelitis.

Pathways for Myelitis

Pathways related to Myelitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
2
Show member pathways
13.82 TNFRSF1A TNF IL9 IL6 IL17A IL10
3
Show member pathways
13.65 TNFRSF1A TNF IL9 IL6 IL17A IL10
4
Show member pathways
13.57 TNFRSF1A TNF IL9 IL6 IL17A IL10
5
Show member pathways
13.36 TNFRSF1A TNF IL9 IL6 IL17A IL10
6
Show member pathways
13.13 TNFRSF1A TNF IL9 IL6 IL17A IL10
7
Show member pathways
13.08 TNFRSF1A TNF MMP9 IL6 IL10 CXCL8
8
Show member pathways
13.04 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
9
Show member pathways
12.83 TNFRSF1A TNF IL6 HLA-DPB1 CXCL8
10
Show member pathways
12.73 TNFRSF1A TNF IL9 IL6 CD40LG
11
Show member pathways
12.66 TNFRSF1A TNF IL10 HLA-DPB1 CD40LG
12
Show member pathways
12.65 TNF IL9 IL6 IL17A IL10 HLA-DPB1
13
Show member pathways
12.62 TNF IL6 IL17A IL10 HLA-DPB1
14
Show member pathways
12.61 TNF IL9 IL6 IL17A IL10 CD40LG
15 12.59 TNFRSF1A TNF IL17A IL10 CD40LG
16
Show member pathways
12.37 TNF MMP9 IL6 IL17A CXCL8 CCL11
17 12.36 TNFRSF1A TNF IL6 HLA-DPB1
18 12.33 TNFRSF1A TNF IL6 CXCL8
19 12.29 TNFRSF1A TNF IL6 CXCL8
20
Show member pathways
12.28 TNFRSF1A TNF IL10 HLA-DPB1 CD40LG
21
Show member pathways
12.27 TNF IL9 IL6 IL17A IL10 CXCL8
22 12.25 TNFRSF1A TNF IL6 IL10 HLA-DPB1
23
Show member pathways
12.25 TNFRSF1A TNF IL6 IL10 CXCL8 CCR6
24 12.21 TNFRSF1A TNF MMP9 IL6
25
Show member pathways
12.21 TNF IL6 CXCL8 CCL11
26 12.18 TNF IL6 IL10 CXCL8 AQP4
27 12.04 TNF IL6 IL10 CXCL8
28 12 TNFRSF1A TNF MMP9 IL6
29
Show member pathways
11.97 TNF IL6 IL17A IL10
30 11.96 TNFRSF1A TNF CXCL8 CD40LG
31 11.96 TNF MMP9 MBP IL6 CXCL8 AQP4
32 11.95 TNF IL6 IL10 CXCL8
33 11.9 TNF IL6 IL17A HLA-DPB1 CXCL8
34
Show member pathways
11.84 TNFRSF1A TNF CD40LG CD27
35 11.81 TNF IL9 IL17A IL10 CCR6
36 11.8 TNF IL6 IL10 CXCL8
37
Show member pathways
11.78 TNF CXCL8 CD40LG
38 11.77 TNF IL6 IL10
39
Show member pathways
11.76 TNFRSF1A TNF CD40LG
40 11.7 MMP9 IL6 CXCL8
41 11.69 TNF MMP9 IL6 CXCL8 CCL11
42 11.68 IL10 CD40LG CCL11
43 11.63 TNF IL6 CXCL8
44 11.58 TNFRSF1A TNF IL6
45 11.55 TNF MMP9 IL6
46 11.55 TNF IL6 IL10 CXCL8 CD40LG
47 11.54 IL6 CXCL8 CCL11
48 11.52 IL9 IL10 CCL11
49 11.52 TNFRSF1A TNF IL6 IL10 CXCL8
50 11.42 TNF IL6 IL10

GO Terms for Myelitis

Cellular components related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 TNFRSF1A TNF MMP9 IL9 IL6 IL17A
2 cell surface GO:0009986 9.76 TNFRSF1A TNF MBP HLA-DPB1 CD40LG CD27
3 external side of plasma membrane GO:0009897 9.5 TNF MOG IL17A CD40LG CD27 CCR6
4 extracellular region GO:0005576 9.44 TNFRSF1A TNF MMP9 IL9 IL6 IL17A

Biological processes related to Myelitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.84 TNF IL6 IL10 CXCL8
2 chemokine-mediated signaling pathway GO:0070098 9.79 CXCL8 CCR6 CCL11
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNFRSF1A TNF IL6
4 response to glucocorticoid GO:0051384 9.77 TNF IL6 IL10
5 inflammatory response GO:0006954 9.76 TNFRSF1A TNF IL9 IL6 IL17A CXCL8
6 positive regulation of T cell proliferation GO:0042102 9.73 IL6 HLA-DPB1 CD40LG
7 humoral immune response GO:0006959 9.72 TNF IL6 CCR6
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.71 TNFRSF1A TNF CD40LG CD27
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.69 TNF MMP9 IL10
10 regulation of neuroinflammatory response GO:0150077 9.63 MMP9 IL6
11 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.63 MBP IL10
12 positive regulation of interleukin-6 secretion GO:2000778 9.63 TNF MBP IL17A
13 response to molecule of bacterial origin GO:0002237 9.62 IL10 CXCL8
14 negative regulation of lipid storage GO:0010888 9.62 TNF IL6
15 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.6 TNF IL17A
16 regulation of establishment of endothelial barrier GO:1903140 9.58 TNFRSF1A TNF
17 endothelial cell apoptotic process GO:0072577 9.58 TNF IL10
18 death-inducing signaling complex assembly GO:0071550 9.57 TNFRSF1A TNF
19 cytokine-mediated signaling pathway GO:0019221 9.56 TNFRSF1A TNF MMP9 IL6 IL17A IL10
20 positive regulation of JAK-STAT cascade GO:0046427 9.54 TNF IL6 IL10
21 negative regulation of cytokine production involved in immune response GO:0002719 9.52 TNF IL10
22 negative regulation of neurogenesis GO:0050768 9.5 TNF IL6 CCL11
23 regulation of immunoglobulin secretion GO:0051023 9.49 TNF CD40LG
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 TNF IL10
25 receptor biosynthetic process GO:0032800 9.43 TNF IL10
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 TNF IL6 IL17A
27 immune response GO:0006955 9.36 TNF MBP IL9 IL6 IL17A IL10

Molecular functions related to Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNF IL9 IL6 IL17A IL10 CXCL8

Sources for Myelitis

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17 EFO
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72 UMLS via Orphanet
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