MCID: MYL044
MIFTS: 24

Myelocystocele

Categories: Neuronal diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Myelocystocele

Summaries for Myelocystocele

MalaCards based summary : Myelocystocele is related to cervicitis and tethered spinal cord syndrome. An important gene associated with Myelocystocele is MT-RNR1 (Mitochondrially Encoded 12S RNA). The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, colon and brain.

Related Diseases for Myelocystocele

Diseases related to Myelocystocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 cervicitis 10.2
2 tethered spinal cord syndrome 10.2
3 syringomyelia 9.9
4 teratoma 9.9
5 neural tube defects 9.9
6 cloacal exstrophy 9.9
7 mature teratoma 9.8
8 sirenomelia 9.8
9 spasticity 9.8
10 diastematomyelia 9.8
11 deafness, aminoglycoside-induced 9.8
12 sacral defect with anterior meningocele 9.8
13 neural tube defects, folate-sensitive 9.8
14 hydrocephalus 9.8
15 sacrococcygeal teratoma 9.8
16 meningocele 9.8

Graphical network of the top 20 diseases related to Myelocystocele:



Diseases related to Myelocystocele

Symptoms & Phenotypes for Myelocystocele

Drugs & Therapeutics for Myelocystocele

Drugs for Myelocystocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
3 abobotulinumtoxinA Phase 4
4 Cholinergic Agents Phase 4,Phase 2
5 Neuromuscular Agents Phase 4
6 Neurotransmitter Agents Phase 4,Phase 2
7 onabotulinumtoxinA Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Botulinum Toxins, Type A Phase 4
10 Botulinum Toxins Phase 4
11
Darifenacin Approved, Investigational Phase 2 133099-04-4 444031
12 Muscarinic Antagonists Phase 2
13 Cholinergic Antagonists Phase 2
14
Methenamine Approved, Vet_approved Phase 1 100-97-0 4101
15 Methenamine hippurate Phase 1
16 Acidophilus Nutraceutical Phase 1
17
Menthol Approved Not Applicable 2216-51-5 16666
18
Nitrous oxide Approved, Vet_approved 10024-97-2 948
19 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
2 2 Week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Yrs) With Neurogenic Detrusor Overactivity Terminated NCT00712322 Phase 2 Darifenacin;Darifenacin;Darifenacin;Darifenacin
3 Bacteriuria Eradication Through Probiotics Unknown status NCT00717600 Phase 1
4 Fetoscopic Meningomyelocele Repair Study Recruiting NCT02230072 Phase 1
5 Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407 Not Applicable
6 Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury Unknown status NCT01606618
7 Fetal Myelomeningocele Completed NCT03073382
8 Management of Myelomeningocele Study (MOMS) Completed NCT00060606 Not Applicable
9 Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele Completed NCT03550898 Not Applicable
10 Evaluation of Hysterotomy Site After Open Fetal Surgery Completed NCT02493062 Not Applicable
11 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584
12 Reliability of the Melbourne Assessment Completed NCT02595411
13 Feasibility of the Portable YouGrabber System Completed NCT02368223 Not Applicable
14 Safety of a Powder-free Latex Allergy Protocol in the Operating Theatre: A Prospective, Observational Cohort Study Completed NCT02575053
15 Prenatal Surgical Repair of Fetal Myelomeningocele Recruiting NCT01983345 Not Applicable
16 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
17 Open Myelomeningocele Repair With High Maternal BMI Recruiting NCT03044821 Not Applicable
18 Prenatal Endoscopic Repair of Fetal Spina Bifida Recruiting NCT02390895 Not Applicable
19 Open Spina Bifida Fetoscopic Repair Project Recruiting NCT03562286 Not Applicable
20 Fetoscopic Repair of Isolated Fetal Spina Bifida Recruiting NCT03090633 Not Applicable
21 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084
22 Fetal Endoscopic Surgery for Spina Bifida Recruiting NCT03315637 Not Applicable
23 Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial Recruiting NCT02361450 Not Applicable
24 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Active, not recruiting NCT01751503 Not Applicable
25 An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience Active, not recruiting NCT03544970
26 Cuff Pressure in Infants Not yet recruiting NCT03088761
27 Incontinence and Quality of Life in Children With Spina Bifida Not yet recruiting NCT03410667 Not Applicable
28 Telemedicine in Spina Bifida Transition: A Pilot Study Not yet recruiting NCT03466996 Not Applicable
29 Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0 Terminated NCT02509377 Not Applicable

Search NIH Clinical Center for Myelocystocele

Genetic Tests for Myelocystocele

Anatomical Context for Myelocystocele

MalaCards organs/tissues related to Myelocystocele:

41
Spinal Cord, Colon, Brain

Publications for Myelocystocele

Articles related to Myelocystocele:

(show all 45)
# Title Authors Year
1
Cervical myelocystocele: rare presentation of spinal dysraphism. ( 29707214 )
2018
2
Early Prenatal MRI of Cervical "Abortive" Myelocystocele: Case Report and Review of the Literature. ( 27880967 )
2016
3
Sonographic images of fetal terminal myelocystocele: a rare form of closed spinal dysraphism. ( 26358950 )
2015
4
A rare case of thoracic myelocystocele associated with type 1 split cord malformation with low lying tethered cord, dorsal syrinx and sacral agenesis: Pentad finding. ( 25552859 )
2015
5
"Giant" terminal myelocystocele: A rare variant of spinal dysraphism. ( 26425175 )
2015
6
Non-terminal cervical myelocystocele: unusual cause of spastic quadriparesis in an adult. ( 25591703 )
2014
7
Terminal myelocystocele with holocord syringomyelia: Short report. ( 24082944 )
2013
8
Pathoembryogenesis of terminal myelocystocele: terminal balloon in secondary neurulation of the chick embryo. ( 23780405 )
2013
9
Terminal myelocystocele. ( 23277377 )
2013
10
Cervicothoracic nonterminal myelocystocele with mature teratoma. ( 24359211 )
2013
11
Dorsolumbosacral agenesis, nonterminal myelocystocele and secondary tonsillar herniation: prenatal and postnatal MRI evaluation and pathological correlation. ( 24080601 )
2013
12
Complete thoracic myelocystocele: a rare benign spinal dysraphism with clinical significance. ( 22082502 )
2012
13
Terminal myelocystocele: surgical observations and theory of embryogenesis. ( 22270234 )
2012
14
Terminal myelocystocele: a series of 30 cases and review of the literature. ( 23548822 )
2012
15
Teaching NeuroImages: terminal myelocystocele. ( 21464423 )
2011
16
Isolated terminal myelocystocele: a rare spinal dysraphism. ( 22953270 )
2011
17
An unusual case of 4 level spinal dysraphism: Multiple composite type 1 and type 2 split cord malformation, dorsal myelocystocele and hydrocephalous. ( 21977092 )
2011
18
Cervical myelocystocele: Case report and review of literature. ( 21977091 )
2011
19
Spontaneous regression of a terminal myelocystocele and associated syringomyelia: a case report. ( 20183927 )
2010
20
Cervical (non-terminal) myelocystocele associated with rapidly progressive hydrocephalus and Chiari type II malformation--case report. ( 20185890 )
2010
21
Cervical myelocystocele: prenatal diagnosis and therapeutical considerations. ( 19212773 )
2009
22
Cervical myelocystocele: prenatal diagnosis and therapeutical considerations. ( 19551388 )
2009
23
Rachipagus parasite associated with myelocystocele and diastematomyelia. ( 18703891 )
2008
24
Holocord hydrosyringomyelia with terminal myelocystocele revealed by constructive interference in steady-state MR imaging. ( 19127095 )
2008
25
Terminal myelocystocele and sacrococcygeal teratoma: a comparison of fetal ultrasound presentation and perinatal risk. ( 17569957 )
2007
26
Prenatal ultrasound diagnosis of cloacal exstrophy associated with myelocystocele complex by the 'elephant trunk-like' image and review of the literature. ( 15909284 )
2005
27
Terminal myelocystocele. ( 16302617 )
2005
28
Terminal myelocystocele. ( 15851075 )
2005
29
Thoracic meningocele, meningomyelocele or myelocystocele? Diagnostic difficulties, consequent implications and treatment. ( 15292637 )
2004
30
Sirenomelia with an angiomatous lumbosacral myelocystocele in a full-term infant. ( 15116133 )
2004
31
Prenatal diagnosis of terminal myelocystocele in the fetal surgery era: case report. ( 11950422 )
2002
32
Terminal myelocystocele. ( 12557964 )
2002
33
Prenatal diagnosis of a fetus with lumbar myelocystocele. ( 11844180 )
2001
34
Myelocystocele-cloacal exstrophy in a pedigree with a mitochondrial 12S rRNA mutation, aminoglycoside-induced deafness, pigmentary disturbances, and spinal anomalies. ( 10661905 )
2000
35
Terminal Myelocystocele:an unusual presentation. ( 10838506 )
2000
36
Long-term outcome of terminal myelocystocele patients. ( 10838507 )
2000
37
Terminal myelocystocele: important differential diagnosis in the prenatal assessment of spina bifida. ( 9514174 )
1998
38
Cervical myelocystocele with Chiari II malformation: magnetic resonance imaging and surgical treatment. ( 9508113 )
1998
39
Special imaging casebook. Terminal myelocystocele. ( 9373852 )
1997
40
Terminal myelocystocele--a case report. ( 8835771 )
1996
41
Prenatal demonstration of a cervical myelocystocele. ( 1279658 )
1992
42
Terminal myelocystocele. ( 3883218 )
1985
43
Prospective management of exstrophy of the cloaca and myelocystocele following prenatal ultrasound recognition of neural tube defects in identical twins. ( 6393766 )
1984
44
Unusual split of the spinal cord in a caudal regression syndrome with myelocystocele. ( 7168484 )
1982
45
Myelocystocele with cerebellar heterotopia. Case report. ( 469585 )
1979

Variations for Myelocystocele

Expression for Myelocystocele

Search GEO for disease gene expression data for Myelocystocele.

Pathways for Myelocystocele

GO Terms for Myelocystocele

Sources for Myelocystocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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