MCID: MYL004
MIFTS: 52

Myelodysplastic Myeloproliferative Cancer

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Myelodysplastic Myeloproliferative Cancer

MalaCards integrated aliases for Myelodysplastic Myeloproliferative Cancer:

Name: Myelodysplastic Myeloproliferative Cancer 38 12
Myelodysplastic/myeloproliferative Neoplasm 12 53 15
Myelodysplastic-Myeloproliferative Diseases 44 73
Myeloproliferative/myelodysplastic Syndromes 12
Myelodysplastic Myeloproliferative Disease 12
Myelodysplastic/myeloproliferative Disease 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4972
MeSH 44 D054437
NCIt 50 C27262
ICD10 33 C94.6
UMLS 73 C1301355

Summaries for Myelodysplastic Myeloproliferative Cancer

NIH Rare Diseases : 53 Myelodysplastic/myeloproliferative diseases are a group of diseases of the blood and bone marrow in which the bone marrow makes too many white blood cells.  These disease have features of both myelodysplastic syndromes and myeloproliferative disorders. In myelodysplastic diseases, the blood stem cells do not mature into healthy red blood cells, white blood cells, or platelets and as a result, there are fewer of these healthy cells. In myeloproliferative diseases, a greater than normal number of blood stem cells develop into one or more types of blood cells and the total number of blood cells slowly increases. The 3 main types of myelodysplastic/myeloproliferative diseases include chronic myelomonocytic leukemia (CMML); juvenile myelomonocytic leukemia (JMML); and atypical chronic myelogenous leukemia (aCML). When a myelodysplastic/myeloproliferative disease does not match any of these types, it is called myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-UC). Symptoms of CMML and JMML may include fever, feeling tired and weight loss. Symptoms of aCML may include easy bruising or bleeding and feeling tired or weak. Myelodysplastic/myeloproliferative diseases may progress to acute leukemia. There are different types of treatment for individuals with one of these diseases, which may include chemotherapy, another drug therapy, stem cell transplant and/or supportive care.

MalaCards based summary : Myelodysplastic Myeloproliferative Cancer, also known as myelodysplastic/myeloproliferative neoplasm, is related to atypical chronic myeloid leukemia and juvenile myelomonocytic leukemia. An important gene associated with Myelodysplastic Myeloproliferative Cancer is PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include bone, bone marrow and myeloid, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A myeloid neoplasm that results in the overproduction of white blood cells.

Related Diseases for Myelodysplastic Myeloproliferative Cancer

Diseases related to Myelodysplastic Myeloproliferative Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 atypical chronic myeloid leukemia 31.8 ABL1 ASXL1 CSF3R JAK2 SETBP1
2 juvenile myelomonocytic leukemia 31.4 CSF2 JAK2 NF1 NRAS PTPN11 SETBP1
3 myeloproliferative neoplasm 30.5 ABL1 JAK2 PTPN11 TET2
4 thrombocytosis 30.4 CSF2 JAK2 TET2
5 refractory anemia 30.0 ASXL1 JAK2 TET2
6 myelofibrosis 29.8 ASXL1 HRAS JAK2 TET2
7 leukemia 29.6 ABL1 CSF2 CSF3R JAK2 NF1 NRAS
8 myeloid leukemia 29.2 ABL1 CSF2 CSF3R HRAS JAK2 NRAS
9 chronic myelomonocytic leukemia 28.8 ASXL1 CSF2 CSF3R JAK2 NF1 PTPN11
10 myelodysplastic syndrome 28.7 ABL1 ASXL1 CSF2 CSF3R HRAS JAK2
11 leukemia, acute myeloid 28.3 ABL1 ASXL1 CSF2 CSF3R HRAS JAK2
12 unclassified myelodysplastic/myeloproliferative disease 12.5
13 neurofibromatosis-noonan syndrome 10.2 NF1 PTPN11
14 autosomal recessive pyridoxine-refractory sideroblastic anemia 2 10.2
15 acquired idiopathic sideroblastic anemia 10.2
16 giant congenital nevus 10.2 HRAS NRAS
17 malignant spindle cell melanoma 10.2 NF1 NRAS
18 benign struma ovarii 10.2 HRAS NRAS
19 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
20 ovarian melanoma 10.2 HRAS NRAS
21 malignant conjunctival melanoma 10.2 HRAS NRAS
22 melanomatosis 10.2 HRAS NRAS
23 marcus gunn phenomenon 10.1 HRAS NRAS
24 malignant struma ovarii 10.1 HRAS NRAS
25 nodular malignant melanoma 10.1 HRAS NRAS
26 mucosal melanoma 10.1 NF1 NRAS
27 fetal adenoma 10.1 HRAS NRAS
28 legius syndrome 10.1 NF1 PTPN11
29 meningeal melanomatosis 10.1 HRAS NRAS
30 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
31 sm-ahnmd 10.1 ASXL1 TET2
32 acneiform dermatitis 10.1 HRAS NRAS
33 acute promyelocytic leukemia 10.1
34 hematopoietic stem cell transplantation 10.1
35 myelophthisic anemia 10.1 JAK2 PTPN11
36 sporadic pheochromocytoma 10.1 HRAS NF1
37 leopard syndrome 10.1 HRAS NF1 PTPN11
38 subacute myeloid leukemia 10.1 JAK2 TET2
39 leukemia, chronic lymphocytic 2 10.1 HRAS NRAS PTPN11
40 pulmonic stenosis 10.1 HRAS NF1 PTPN11
41 neurofibromatosis, type iv, of riccardi 10.1 HRAS NF1 PTPN11
42 vulvar melanoma 10.1 HRAS NF1 NRAS
43 malignant skin fibrous histiocytoma 10.1 HRAS NRAS
44 anemia, sideroblastic, and spinocerebellar ataxia 10.1 RARS TET2
45 liver angiosarcoma 10.1 HRAS NRAS
46 malignant dermis tumor 10.0 HRAS NRAS
47 chronic neutrophilic leukemia 10.0 ASXL1 CSF3R SETBP1
48 splenomegaly 10.0 JAK2 SETBP1
49 noonan syndrome 1 10.0 HRAS NF1 NRAS PTPN11
50 core binding factor acute myeloid leukemia 10.0 HRAS JAK2 NRAS

Graphical network of the top 20 diseases related to Myelodysplastic Myeloproliferative Cancer:



Diseases related to Myelodysplastic Myeloproliferative Cancer

Symptoms & Phenotypes for Myelodysplastic Myeloproliferative Cancer

GenomeRNAi Phenotypes related to Myelodysplastic Myeloproliferative Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.89 HRAS
2 Decreased viability GR00221-A-1 9.89 ABL1 HRAS NF1 NRAS
3 Decreased viability GR00221-A-2 9.89 ABL1 HRAS JAK2 NF1
4 Decreased viability GR00221-A-3 9.89 ABL1 HRAS NRAS
5 Decreased viability GR00221-A-4 9.89 NF1
6 Decreased viability GR00342-S-1 9.89 ABL1
7 Decreased viability GR00342-S-2 9.89 ABL1
8 Decreased viability GR00342-S-3 9.89 ABL1
9 Decreased viability GR00402-S-2 9.89 ABL1 HRAS JAK2 NF1 NRAS
10 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.26 ABL1 HRAS NRAS PTPN11

MGI Mouse Phenotypes related to Myelodysplastic Myeloproliferative Cancer:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 ABL1 ASXL1 CSF2 CSF3R JAK2 NF1
2 endocrine/exocrine gland MP:0005379 10.19 ABL1 ASXL1 CSF2 CSF3R HRAS JAK2
3 behavior/neurological MP:0005386 10.17 ABL1 ASXL1 CSF2 HRAS NF1 NRAS
4 cardiovascular system MP:0005385 10.16 ABL1 CSF2 CSF3R HRAS NF1 NRAS
5 growth/size/body region MP:0005378 10.13 ABL1 ASXL1 CSF2 HRAS JAK2 NF1
6 hematopoietic system MP:0005397 10.11 ABL1 ASXL1 CSF2 CSF3R JAK2 NF1
7 homeostasis/metabolism MP:0005376 10.09 ABL1 ASXL1 CSF2 HRAS JAK2 NF1
8 craniofacial MP:0005382 10.08 ABL1 ASXL1 CSF2 HRAS NF1 NRAS
9 immune system MP:0005387 10.06 ABL1 ASXL1 CSF2 CSF3R JAK2 NF1
10 digestive/alimentary MP:0005381 10 ABL1 ASXL1 HRAS NF1 NRAS PTPN11
11 mortality/aging MP:0010768 10 ABL1 ASXL1 CSF2 CSF3R HRAS JAK2
12 embryo MP:0005380 9.99 ABL1 CSF2 JAK2 NF1 NRAS PTPN11
13 integument MP:0010771 9.91 CSF2 HRAS JAK2 NF1 NRAS PTPN11
14 liver/biliary system MP:0005370 9.87 ABL1 ASXL1 JAK2 NF1 NRAS PTPN11
15 neoplasm MP:0002006 9.76 ASXL1 CSF2 HRAS JAK2 NF1 NRAS
16 normal MP:0002873 9.5 ABL1 HRAS JAK2 NF1 NRAS PTPN11
17 skeleton MP:0005390 9.23 ABL1 ASXL1 CSF2 HRAS JAK2 NF1

Drugs & Therapeutics for Myelodysplastic Myeloproliferative Cancer

Search Clinical Trials , NIH Clinical Center for Myelodysplastic Myeloproliferative Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Myelodysplastic Myeloproliferative Cancer:
NiCord�, umbilical cord blood-derived stem/progenitor cells for hemotological diseases
Embryonic/Adult Cultured Cells Related to Myelodysplastic Myeloproliferative Cancer:
Umbilical cord blood-derived stem cells (NiCord) PMIDs: 22198152

Cochrane evidence based reviews: myelodysplastic-myeloproliferative diseases

Genetic Tests for Myelodysplastic Myeloproliferative Cancer

Anatomical Context for Myelodysplastic Myeloproliferative Cancer

MalaCards organs/tissues related to Myelodysplastic Myeloproliferative Cancer:

41
Bone, Bone Marrow, Myeloid, T Cells, Liver, Skin, Brain

Publications for Myelodysplastic Myeloproliferative Cancer

Articles related to Myelodysplastic Myeloproliferative Cancer:

(show all 12)
# Title Authors Year
1
Hypomethylating agents (HMAs) effect on myelodysplastic/myeloproliferative neoplasm unclassifiable (MDS/MPN-U): single institution experience. ( 29465270 )
2018
2
Atypical chronic myeloid leukaemia - aA rare subtype of myelodysplastic/myeloproliferative neoplasm. ( 29692658 )
2018
3
Mutational landscape of myelodysplastic/myeloproliferative neoplasm-unclassifiable. ( 30242087 )
2018
4
A case of SF3B1 positive myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis. ( 30468430 )
2018
5
Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis with co-mutated JAK2 and SF3B1. ( 28153838 )
2017
6
Suspected myelodysplastic/myeloproliferative neoplasm in a feline leukemia virus-negative cat. ( 27870069 )
2016
7
Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia. ( 27240832 )
2016
8
I walk the other line: myelodysplastic/myeloproliferative neoplasm overlap syndromes. ( 25195196 )
2014
9
A transient myelodysplastic/myeloproliferative neoplasm in a patient with cardio-facio-cutaneous syndrome and a germline BRAF mutation. ( 23950000 )
2013
10
Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. ( 22198154 )
2012
11
A case of JAK2 V617F-positive myelodysplastic/myeloproliferative neoplasm with unusual morphology, resembling acute promyelocytic leukemia-like disorder with a chronic course. ( 21635206 )
2011
12
Pathology of the bone marrow and spleen in a case of myelodysplastic/myeloproliferative neoplasm associated with t(8;9)(p22;p24) involving PCM1 and JAK2 genes. ( 21070368 )
2011

Variations for Myelodysplastic Myeloproliferative Cancer

Expression for Myelodysplastic Myeloproliferative Cancer

Search GEO for disease gene expression data for Myelodysplastic Myeloproliferative Cancer.

Pathways for Myelodysplastic Myeloproliferative Cancer

Pathways related to Myelodysplastic Myeloproliferative Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 ABL1 CSF2 CSF3R HRAS JAK2 NF1
2
Show member pathways
13.32 ABL1 CSF2 HRAS JAK2 NF1 NRAS
3
Show member pathways
13.19 ABL1 CSF2 HRAS JAK2 NRAS PTPN11
4
Show member pathways
13.16 CSF2 CSF3R HRAS JAK2 NRAS PTPN11
5
Show member pathways
13.11 CSF2 CSF3R HRAS JAK2 NF1 NRAS
6
Show member pathways
12.73 ABL1 CSF2 HRAS NRAS PTPN11
7
Show member pathways
12.71 ABL1 HRAS JAK2 NRAS
8 12.7 ABL1 CSF3R HRAS JAK2 NRAS
9
Show member pathways
12.67 HRAS JAK2 NF1 NRAS
10
Show member pathways
12.62 ABL1 HRAS NRAS PTPN11
11
Show member pathways
12.55 ABL1 HRAS NF1 NRAS PTPN11
12
Show member pathways
12.49 HRAS JAK2 NRAS PTPN11
13
Show member pathways
12.48 CSF2 HRAS NRAS PTPN11
14
Show member pathways
12.41 CSF2 HRAS NRAS PTPN11
15
Show member pathways
12.38 HRAS JAK2 NRAS PTPN11
16
Show member pathways
12.37 ABL1 HRAS NRAS PTPN11
17
Show member pathways
12.32 CSF2 HRAS NRAS PTPN11
18
Show member pathways
12.29 HRAS JAK2 NF1 PTPN11
19 12.21 HRAS NRAS PTPN11
20
Show member pathways
12.19 HRAS NRAS PTPN11
21
Show member pathways
12.15 HRAS JAK2 NF1 NRAS
22
Show member pathways
12.14 HRAS NRAS PTPN11
23
Show member pathways
12.13 HRAS NRAS PTPN11
24
Show member pathways
12.13 HRAS JAK2 NRAS PTPN11
25
Show member pathways
12.09 HRAS JAK2 PTPN11
26
Show member pathways
12.06 CSF2 JAK2 PTPN11
27 12.05 CSF3R HRAS NRAS
28
Show member pathways
12.05 HRAS NRAS PTPN11
29 12.04 ABL1 HRAS NRAS PTPN11
30 12.02 HRAS JAK2 PTPN11
31 12 HRAS JAK2 NRAS
32 11.99 ABL1 HRAS JAK2 PTPN11
33
Show member pathways
11.98 HRAS JAK2 PTPN11
34
Show member pathways
11.98 HRAS JAK2 NRAS PTPN11
35
Show member pathways
11.97 HRAS NF1 NRAS
36 11.91 ABL1 HRAS NRAS
37 11.89 HRAS NF1 NRAS
38
Show member pathways
11.88 HRAS JAK2 PTPN11
39
Show member pathways
11.87 HRAS JAK2 NRAS
40
Show member pathways
11.87 ABL1 CSF2 CSF3R HRAS JAK2 NRAS
41
Show member pathways
11.83 ABL1 HRAS JAK2 NRAS
42 11.82 HRAS JAK2 NRAS
43
Show member pathways
11.81 HRAS JAK2 PTPN11
44
Show member pathways
11.8 HRAS JAK2 NF1 NRAS
45 11.61 HRAS NF1 NRAS PTPN11
46
Show member pathways
11.59 HRAS JAK2 NRAS
47 11.47 ABL1 HRAS PTPN11
48 11.39 HRAS NF1 NRAS
49 11.34 HRAS JAK2 PTPN11
50 11.25 HRAS PTPN11

GO Terms for Myelodysplastic Myeloproliferative Cancer

Biological processes related to Myelodysplastic Myeloproliferative Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.69 ABL1 CSF2 JAK2
2 regulation of cell proliferation GO:0042127 9.67 ABL1 CSF2 NF1
3 cytokine-mediated signaling pathway GO:0019221 9.62 CSF2 CSF3R JAK2 PTPN11
4 positive regulation of mitotic cell cycle GO:0045931 9.52 ABL1 PTPN11
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 HRAS NF1
6 positive regulation of actin cytoskeleton reorganization GO:2000251 9.46 ABL1 HRAS
7 interleukin-6-mediated signaling pathway GO:0070102 9.43 JAK2 PTPN11
8 negative regulation of cell-cell adhesion GO:0022408 9.4 ABL1 JAK2
9 regulation of myeloid cell differentiation GO:0045637 9.37 CSF2 CSF3R
10 Ras protein signal transduction GO:0007265 9.33 HRAS NF1 NRAS
11 Bergmann glial cell differentiation GO:0060020 9.26 ABL1 PTPN11
12 platelet-derived growth factor receptor signaling pathway GO:0048008 9.13 ABL1 JAK2 PTPN11
13 MAPK cascade GO:0000165 9.02 CSF2 HRAS JAK2 NF1 NRAS

Molecular functions related to Myelodysplastic Myeloproliferative Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.56 HRAS JAK2 NRAS RARS
2 protein C-terminus binding GO:0008022 9.54 ABL1 HRAS JAK2
3 protein tyrosine kinase activity GO:0004713 9.5 ABL1 CSF2 JAK2
4 protein binding GO:0005515 9.4 ABL1 ASXL1 CSF2 CSF3R HRAS JAK2
5 insulin receptor substrate binding GO:0043560 9.16 JAK2 PTPN11
6 peptide hormone receptor binding GO:0051428 8.96 JAK2 PTPN11

Sources for Myelodysplastic Myeloproliferative Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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