MCID: MYL062
MIFTS: 26

Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

Name: Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080167
NCIt 49 C84277

Summaries for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Disease Ontology : 12 A myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the FGFR1 gene, resulting in translocations with an 8p11 breakpoint.

MalaCards based summary : Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is related to myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 and large granular lymphocyte leukemia. An important gene associated with Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is ZNF112 (Zinc Finger Protein 112), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include myeloid, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.3 ZNF112 ZMYM2 FGFR1
2 large granular lymphocyte leukemia 10.3 STAT5B IL2RA
3 glioblastoma neural subtype 10.1 STAT5B STAT5A
4 jak3-deficient severe combined immunodeficiency 10.1 STAT5B STAT5A
5 pilonidal sinus 10.0 IL2RA CD4
6 adenohypophysitis 10.0 IL2RA CD4
7 t-cell large granular lymphocyte leukemia 10.0 STAT5B IL2RA CD8A
8 chronic graft versus host disease 10.0 IL2RA CD4
9 8p11 myeloproliferative syndrome 9.9 ZMYM2 FLT3 FGFR1OP2 FGFR1
10 cork-handlers' disease 9.9 CD8A CD4
11 disseminated eosinophilic collagen disease 9.9 IL3 IL2RA
12 ventilation pneumonitis 9.9 CD8A CD4
13 diffuse infiltrative lymphocytosis syndrome 9.9 CD8A CD4
14 diabetes mellitus, insulin-dependent, 23 9.9 CD8A CD4
15 autoimmune lymphoproliferative syndrome, type iia 9.9 CD8A CD4
16 early yaws 9.9 CD8A CD4
17 bird fancier's lung 9.9 CD8A CD4
18 parapsoriasis 9.9 CD8A CD4
19 norwegian scabies 9.9 CD8A CD4
20 skin sarcoidosis 9.9 CD8A CD4
21 variola major 9.9 CD8A CD4
22 follicular mucinosis 9.8 CD8A CD4
23 viral exanthem 9.8 CD8A CD4
24 tertiary syphilis 9.8 CD8A CD4
25 spongiotic dermatitis 9.8 CD8A CD4
26 acute retinal necrosis syndrome 9.8 CD8A CD4
27 invasive malignant thymoma 9.8 CD8A CD4
28 metal allergy 9.8 CD8A CD4
29 cerebritis 9.8 CD8A CD4
30 granulomatous hepatitis 9.8 CD8A CD4
31 acute interstitial pneumonia 9.8 CD8A CD4
32 west nile encephalitis 9.8 CD8A CD4
33 oral hairy leukoplakia 9.8 CD8A CD4
34 superficial basal cell carcinoma 9.8 CD8A CD4
35 secondary syphilis 9.8 CD8A CD4
36 glanders 9.8 CD8A CD4
37 parotid disease 9.8 CD8A CD4
38 nickel allergic contact dermatitis 9.7 CD8A CD4
39 bell's palsy 9.7 IL2RA CD8A CD4
40 cervicitis 9.7 IL2RA CD8A CD4
41 west nile fever 9.7 CD8A CD4
42 systemic mastocytosis 9.7 STAT5B STAT5A IL2RA FGFR1
43 neurosarcoidosis 9.7 CD8A CD4
44 myelodysplastic/myeloproliferative neoplasm 9.7 STAT5B STAT5A FLT3
45 autoimmune disease of endocrine system 9.7 IL2RA CD8A CD4
46 esophageal candidiasis 9.7 CD8A CD4
47 chronic leukemia 9.7 STAT5B STAT5A FLT3
48 cardiomyopathy, familial hypertrophic, 9 9.7 CD8A CD4
49 cryptococcal meningitis 9.7 SRC CD8A CD4
50 hypereosinophilic syndrome 9.6 STAT5B IL3 IL2RA FGFR1

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:



Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 BAD CD4 CD8A FGFR1 FLT3 IL2RA
2 hematopoietic system MP:0005397 9.96 BAD CD4 CD8A FGFR1 FLT3 IL2RA
3 immune system MP:0005387 9.85 BAD CD4 CD8A FGFR1 FLT3 IL2RA
4 integument MP:0010771 9.56 CD4 CD8A FGFR1 LSR NOTCH1 SRC
5 mortality/aging MP:0010768 9.4 BAD CD4 CD8A FGFR1 FLT3 IL2RA

Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Genetic Tests for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Anatomical Context for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

40
Myeloid

Publications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Variations for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Expression for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities.

Pathways for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Pathways related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 STAT5B STAT5A SRC IL3 IL2RA FLT3
2
Show member pathways
13.74 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
3
Show member pathways
13.65 STAT5B STAT5A SRC IL3 IL2RA FLT3
4
Show member pathways
13.63 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
5
Show member pathways
13.54 ZMYM2 STAT5B STAT5A SRC RPL13 NOTCH1
6
Show member pathways
13.51 STAT5B STAT5A SRC IL3 IL2RA FLT3
7
Show member pathways
13.32 STAT5B STAT5A SRC IL3 IL2RA FLT3
8
Show member pathways
13.29 STAT5B STAT5A SRC IL3 IL2RA FLT3
9
Show member pathways
13.27 SRC NOTCH1 IL3 IL2RA FGFR1 CD4
10
Show member pathways
12.96 NOTCH1 IL3 IL2RA FLT3 FGFR1 BAD
11
Show member pathways
12.89 STAT5B STAT5A SRC CD8A CD4
12
Show member pathways
12.85 STAT5B STAT5A SRC CD4 BAD
13
Show member pathways
12.79 STAT5B STAT5A SRC IL3 FLT3 FGFR1
14
Show member pathways
12.61 STAT5B STAT5A SRC NOTCH1 FGFR1 BAD
15 12.58 STAT5B STAT5A NOTCH1 IL3 IL2RA FLT3
16
Show member pathways
12.57 STAT5B STAT5A NOTCH1 IL2RA CD4
17
Show member pathways
12.55 STAT5B STAT5A SRC CD4 BAD
18 12.52 STAT5B STAT5A IL3 IL2RA CD8A
19
Show member pathways
12.46 STAT5B STAT5A SRC BAD
20
Show member pathways
12.43 STAT5B STAT5A SRC IL3 IL2RA
21
Show member pathways
12.38 STAT5A SRC IL3 FLT3 FGFR1
22
Show member pathways
12.36 STAT5A SRC FLT3 FGFR1 BAD
23 12.32 STAT5B STAT5A IL2RA CD4
24
Show member pathways
12.29 STAT5B STAT5A IL3 FLT3 BAD
25 12.28 STAT5B STAT5A SRC BAD
26
Show member pathways
12.2 SRC IL2RA FGFR1 BAD
27
Show member pathways
12.11 STAT5B STAT5A SRC IL3 BAD
28
Show member pathways
12.09 STAT5B STAT5A IL2RA
29 12.08 STAT5B STAT5A SRC BAD
30 11.98 SRC NOTCH1 BAD
31
Show member pathways
11.94 STAT5A IL2RA CD8A CD4
32
Show member pathways
11.92 STAT5B STAT5A CD4
33
Show member pathways
11.87 STAT5B STAT5A SRC
34
Show member pathways
11.84 STAT5B STAT5A CD4
35
Show member pathways
11.84 STAT5B STAT5A IL3
36
Show member pathways
11.83 ZMYM2 STAT5B STAT5A FGFR1OP2 FGFR1 CUX1
37
Show member pathways
11.79 FLT3 FGFR1 BAD
38 11.77 IL2RA CD8A CD4
39 11.76 IL3 IL2RA FLT3 CD8A CD4
40 11.74 FLT3 CD8A CD4
41
Show member pathways
11.69 STAT5B STAT5A IL2RA
42 11.67 STAT5B STAT5A SRC
43 11.6 STAT5B STAT5A SRC CD4 BAD
44 11.57 STAT5B STAT5A SRC
45 11.54 STAT5B STAT5A SRC
46 11.52 STAT5A NOTCH1 IL3
47 11.5 STAT5B SRC FGFR1
48 11.5 NOTCH1 IL3 IL2RA FLT3 CD8A CD4
49
Show member pathways
11.45 STAT5B STAT5A SRC
50 11.45 STAT5B STAT5A SRC IL2RA

GO Terms for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Cellular components related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.36 ZMYM2 STAT5B STAT5A SRC RPL13 NOTCH1

Biological processes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 STAT5B NOTCH1 IL3 FLT3 FGFR1
2 immune response GO:0006955 9.83 NOTCH1 IL3 IL2RA CD8A CD4
3 MAPK cascade GO:0000165 9.81 IL3 IL2RA FLT3 FGFR1
4 positive regulation of MAPK cascade GO:0043410 9.77 FLT3 FGFR1 CD4
5 response to estradiol GO:0032355 9.75 STAT5B CD4 BAD
6 regulation of cell proliferation GO:0042127 9.72 STAT5B STAT5A SRC NOTCH1 FGFR1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 SRC IL3 CD4
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.7 SRC FLT3 FGFR1
9 positive regulation of kinase activity GO:0033674 9.63 FLT3 FGFR1 CD4
10 negative regulation of anoikis GO:2000811 9.58 SRC NOTCH1
11 positive regulation of MAP kinase activity GO:0043406 9.58 SRC FLT3 FGFR1
12 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.57 STAT5B STAT5A
13 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.56 STAT5B CD4
14 positive regulation of B cell differentiation GO:0045579 9.55 STAT5B BAD
15 interleukin-9-mediated signaling pathway GO:0038113 9.48 STAT5B STAT5A
16 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT5B STAT5A CD4
17 taurine metabolic process GO:0019530 9.37 STAT5B STAT5A
18 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.35 SRC FLT3 FGFR1 CD8A CD4
19 interleukin-2-mediated signaling pathway GO:0038110 9.33 STAT5B STAT5A IL2RA
20 cytokine-mediated signaling pathway GO:0019221 9.17 STAT5B STAT5A IL3 IL2RA FLT3 CD4

Molecular functions related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucocorticoid receptor binding GO:0035259 8.62 STAT5B FLT3

Sources for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

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