MCID: MYL062
MIFTS: 25

Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

Name: Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080167
NCIt 50 C84277

Summaries for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Disease Ontology : 12 A myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the FGFR1 gene, resulting in translocations with an 8p11 breakpoint.

MalaCards based summary : Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is related to pilonidal sinus and adenohypophysitis. An important gene associated with Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is ZNF112 (Zinc Finger Protein 112), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include myeloid, and related phenotypes are endocrine/exocrine gland and mortality/aging

Related Diseases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 pilonidal sinus 10.2 IL2RA CD4
2 adenohypophysitis 10.2 IL2RA CD4
3 cork-handlers' disease 10.2 CD8A CD4
4 necrotic uveal melanoma 10.2 CD8A CD4
5 early yaws 10.2 CD8A CD4
6 ventilation pneumonitis 10.2 CD8A CD4
7 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
8 latent syphilis 10.2 CD8A CD4
9 type 1 diabetes mellitus 23 10.2 CD8A CD4
10 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
11 parapsoriasis 10.2 CD8A CD4
12 gastroduodenitis 10.2 CD8A CD4
13 duodenitis 10.2 CD8A CD4
14 primary syphilis 10.2 CD8A CD4
15 norwegian scabies 10.2 CD8A CD4
16 bird fancier's lung 10.2 CD8A CD4
17 skin sarcoidosis 10.2 CD8A CD4
18 metal allergy 10.2 CD8A CD4
19 variola major 10.2 CD8A CD4
20 follicular mucinosis 10.2 CD8A CD4
21 tertiary syphilis 10.2 CD8A CD4
22 spongiotic dermatitis 10.2 CD8A CD4
23 acute retinal necrosis syndrome 10.2 CD8A CD4
24 cerebral lymphoma 10.2 CD8A CD4
25 oral tuberculosis 10.2 CD8A CD4
26 cerebritis 10.2 CD8A CD4
27 invasive malignant thymoma 10.1 CD8A CD4
28 west nile encephalitis 10.1 CD8A CD4
29 granulomatous hepatitis 10.1 CD8A CD4
30 exanthema subitum 10.1 CD8A CD4
31 immunodeficiency 36 10.1 CD8A CD4
32 viral exanthem 10.1 CD8A CD4
33 secondary syphilis 10.1 CD8A CD4
34 glanders 10.1 CD8A CD4
35 oral hairy leukoplakia 10.1 CD8A CD4
36 superficial basal cell carcinoma 10.1 CD8A CD4
37 esophageal candidiasis 10.1 CD8A CD4
38 parotid disease 10.1 CD8A CD4
39 ulcerative stomatitis 10.1 CD8A CD4
40 granulomatous dermatitis 10.1 CD8A CD4
41 west nile fever 10.1 CD8A CD4
42 neurosarcoidosis 10.1 CD8A CD4
43 retinitis pigmentosa 46 10.1 CD8A CD4
44 pneumonic tularemia 10.1 CD8A CD4
45 farmer's lung 10.1 CD8A CD4
46 uveoparotid fever 10.1 CD8A CD4
47 adenoid hypertrophy 10.1 CD8A CD4
48 nickel allergic contact dermatitis 10.1 CD8A CD4
49 scleral disease 10.1 CD8A CD4
50 pneumonic plague 10.1 CD8A CD4

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:



Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.61 CD4 CD8A FGFR1 FLT3 IL2RA NOTCH1
2 mortality/aging MP:0010768 9.36 CD4 CD8A FGFR1 FGFR1OP2 FLT3 IL2RA

Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Genetic Tests for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Anatomical Context for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

40
Myeloid

Publications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Variations for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Expression for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities.

Pathways for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Pathways related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
2
Show member pathways
13.61 STAT5B STAT5A SRC IL3 IL2RA FLT3
3
Show member pathways
13.55 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
4
Show member pathways
13.5 ZMYM2 STAT5B STAT5A SRC RPL13 NOTCH1
5
Show member pathways
13.45 STAT5B STAT5A SRC IL3 IL2RA FLT3
6
Show member pathways
13.26 STAT5B STAT5A SRC IL3 IL2RA FLT3
7
Show member pathways
13.24 SRC NOTCH1 IL3 IL2RA FGFR1 CD4
8
Show member pathways
13.19 STAT5B STAT5A SRC IL3 IL2RA FLT3
9
Show member pathways
12.93 NOTCH1 IL3 IL2RA FLT3 FGFR1
10
Show member pathways
12.87 STAT5B STAT5A SRC CD8A CD4
11
Show member pathways
12.76 STAT5B STAT5A SRC IL3 FLT3 FGFR1
12
Show member pathways
12.62 STAT5B STAT5A SRC NOTCH1 FGFR1
13 12.59 STAT5B STAT5A NOTCH1 IL3 IL2RA FLT3
14
Show member pathways
12.53 STAT5B STAT5A SRC CD4
15
Show member pathways
12.51 STAT5B STAT5A NOTCH1 IL2RA CD4
16 12.48 STAT5B STAT5A IL3 IL2RA CD8A
17
Show member pathways
12.36 STAT5A SRC FLT3 FGFR1
18
Show member pathways
12.35 STAT5A SRC IL3 FLT3 FGFR1
19 12.3 STAT5B STAT5A IL2RA CD4
20
Show member pathways
12.29 STAT5B STAT5A IL3 FLT3
21
Show member pathways
12.29 STAT5B STAT5A SRC IL3 IL2RA
22
Show member pathways
12.11 STAT5B STAT5A SRC IL3
23 12.02 SRC CD8A CD4
24
Show member pathways
12.01 STAT5B STAT5A IL2RA
25
Show member pathways
11.9 STAT5A IL2RA CD8A CD4
26
Show member pathways
11.86 STAT5B STAT5A SRC
27
Show member pathways
11.83 ZMYM2 STAT5B STAT5A FGFR1OP2 FGFR1 CUX1
28
Show member pathways
11.82 STAT5B STAT5A CD4
29
Show member pathways
11.79 STAT5B STAT5A IL3
30 11.76 IL2RA CD8A CD4
31
Show member pathways
11.74 STAT5B STAT5A CD4
32 11.72 FLT3 CD8A CD4
33 11.71 STAT5B STAT5A IL2RA
34
Show member pathways
11.67 STAT5B STAT5A IL2RA
35 11.66 STAT5B STAT5A SRC
36 11.65 IL3 IL2RA FLT3 CD8A CD4
37 11.64 STAT5B STAT5A SRC CD4
38 11.55 STAT5B STAT5A SRC
39 11.51 STAT5B STAT5A SRC
40 11.5 NOTCH1 IL3 IL2RA FLT3 CD8A CD4
41 11.49 STAT5A NOTCH1 IL3
42 11.48 STAT5B SRC FGFR1
43
Show member pathways
11.44 STAT5B STAT5A IL2RA
44
Show member pathways
11.4 STAT5B STAT5A SRC
45 11.38 STAT5B STAT5A SRC IL2RA
46 11.33 STAT5A NOTCH1 IL2RA CD4
47
Show member pathways
11.2 STAT5B STAT5A IL2RA
48
Show member pathways
11.18 STAT5B STAT5A IL2RA
49
Show member pathways
11.05 ZMYM2 STAT5B STAT5A FGFR1OP2 FGFR1 CUX1
50 10.98 STAT5B STAT5A

GO Terms for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Biological processes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 STAT5B NOTCH1 IL3 FLT3 FGFR1
2 immune response GO:0006955 9.83 NOTCH1 IL3 IL2RA CD8A CD4
3 MAPK cascade GO:0000165 9.81 IL3 IL2RA FLT3 FGFR1
4 peptidyl-tyrosine phosphorylation GO:0018108 9.75 SRC FLT3 FGFR1
5 positive regulation of MAPK cascade GO:0043410 9.73 FLT3 FGFR1 CD4
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 SRC IL3 CD4
7 regulation of cell proliferation GO:0042127 9.71 STAT5B STAT5A SRC NOTCH1
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.7 SRC FLT3 FGFR1
9 positive regulation of kinase activity GO:0033674 9.63 FLT3 FGFR1 CD4
10 negative regulation of anoikis GO:2000811 9.57 SRC NOTCH1
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.55 STAT5B STAT5A
12 positive regulation of MAP kinase activity GO:0043406 9.54 SRC FLT3 FGFR1
13 interleukin-9-mediated signaling pathway GO:0038113 9.49 STAT5B STAT5A
14 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT5B STAT5A CD4
15 cytokine-mediated signaling pathway GO:0019221 9.43 STAT5B STAT5A IL3 IL2RA FLT3 CD4
16 interleukin-2-mediated signaling pathway GO:0038110 9.33 STAT5B STAT5A IL2RA
17 taurine metabolic process GO:0019530 9.32 STAT5B STAT5A
18 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.02 SRC FLT3 FGFR1 CD8A CD4

Molecular functions related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.13 SRC FLT3 FGFR1
2 glucocorticoid receptor binding GO:0035259 8.62 STAT5B FLT3

Sources for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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