MCID: MYL062
MIFTS: 28

Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards integrated aliases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

Name: Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080167
NCIt 49 C84277

Summaries for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Disease Ontology : 12 A myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the FGFR1 gene, resulting in translocations with an 8p11 breakpoint.

MalaCards based summary : Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is related to myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 and large granular lymphocyte leukemia. An important gene associated with Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities is ZNF112 (Zinc Finger Protein 112), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include myeloid, t cells and lung, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.3 ZNF112 ZMYM2 FGFR1
2 large granular lymphocyte leukemia 10.3 STAT5B IL2RA
3 pilonidal sinus 10.2 IL2RA CD4
4 adenohypophysitis 10.2 IL2RA CD4
5 chronic graft versus host disease 10.1 IL2RA CD4
6 localized chondrosarcoma 10.1 SRC LSR FGFR1
7 glioblastoma neural subtype 10.1 STAT5B STAT5A
8 cork-handlers' disease 10.1 CD8A CD4
9 jak3-deficient severe combined immunodeficiency 10.1 STAT5B STAT5A
10 syphilitic meningitis 10.1 CD8A CD4
11 ventilation pneumonitis 10.0 CD8A CD4
12 diffuse infiltrative lymphocytosis syndrome 10.0 CD8A CD4
13 autoimmune lymphoproliferative syndrome, type iia 10.0 CD8A CD4
14 chromosome 14q11-q22 deletion syndrome 10.0 CD8A CD4
15 diabetes mellitus, insulin-dependent, 23 10.0 CD8A CD4
16 bird fancier's lung 10.0 CD8A CD4
17 early yaws 10.0 CD8A CD4
18 parapsoriasis 10.0 CD8A CD4
19 norwegian scabies 10.0 CD8A CD4
20 metal allergy 10.0 CD8A CD4
21 variola major 10.0 CD8A CD4
22 follicular mucinosis 10.0 CD8A CD4
23 tertiary syphilis 10.0 CD8A CD4
24 spongiotic dermatitis 10.0 CD8A CD4
25 acute retinal necrosis syndrome 10.0 CD8A CD4
26 granulomatous hepatitis 10.0 CD8A CD4
27 nickel allergic contact dermatitis 10.0 CD8A CD4
28 combined thymoma 10.0 CD8A CD4
29 west nile encephalitis 10.0 CD8A CD4
30 neurosarcoidosis 10.0 CD8A CD4
31 immunodeficiency 18 10.0 CD8A CD4
32 cerebritis 10.0 CD8A CD4
33 acute interstitial pneumonia 9.9 CD8A CD4
34 parotid disease 9.9 CD8A CD4
35 8p11 myeloproliferative syndrome 9.9 ZMYM2 FLT3 FGFR1OP2 FGFR1
36 superficial basal cell carcinoma 9.9 CD8A CD4
37 secondary syphilis 9.9 CD8A CD4
38 chronic eosinophilic leukemia 9.9 STAT5B FLT3 FGFR1
39 oral tuberculosis 9.9 CD8A CD4
40 disseminated eosinophilic collagen disease 9.9 IL3 IL2RA
41 t-cell adult acute lymphocytic leukemia 9.9 IL2RA CD8A CD4
42 oral hairy leukoplakia 9.9 CD8A CD4
43 cervicitis 9.9 IL2RA CD8A CD4
44 farmer's lung 9.9 CD8A CD4
45 autoimmune disease of endocrine system 9.9 IL2RA CD8A CD4
46 esophageal candidiasis 9.9 CD8A CD4
47 immunodeficiency 19 9.8 CD8A CD4
48 cardiomyopathy, familial hypertrophic, 9 9.8 CD8A CD4
49 cryptococcal meningitis 9.8 SRC CD8A CD4
50 cd3zeta deficiency 9.8 LSR CD8A CD4

Graphical network of the top 20 diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:



Diseases related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Symptoms & Phenotypes for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MGI Mouse Phenotypes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 BAD CD4 CD8A FGFR1 FLT3 IL2RA
2 hematopoietic system MP:0005397 9.96 BAD CD4 CD8A FGFR1 FLT3 IL2RA
3 immune system MP:0005387 9.85 BAD CD4 CD8A FGFR1 FLT3 IL2RA
4 integument MP:0010771 9.56 CD4 CD8A FGFR1 LSR NOTCH1 SRC
5 mortality/aging MP:0010768 9.4 BAD CD4 CD8A FGFR1 FLT3 IL2RA

Drugs & Therapeutics for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search Clinical Trials , NIH Clinical Center for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities

Genetic Tests for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Anatomical Context for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

MalaCards organs/tissues related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities:

40
Myeloid, T Cells, Lung, Bone Marrow, Bone

Publications for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Variations for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Expression for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Search GEO for disease gene expression data for Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities.

Pathways for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Pathways related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 STAT5B STAT5A SRC IL3 IL2RA FLT3
2
Show member pathways
13.74 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
3
Show member pathways
13.65 STAT5B STAT5A SRC IL3 IL2RA FLT3
4
Show member pathways
13.64 STAT5B STAT5A SRC NOTCH1 IL3 IL2RA
5
Show member pathways
13.56 ZMYM2 STAT5B STAT5A SRC RPL13 NOTCH1
6
Show member pathways
13.51 STAT5B STAT5A SRC IL3 IL2RA FLT3
7
Show member pathways
13.34 STAT5B STAT5A SRC IL3 IL2RA FLT3
8
Show member pathways
13.3 STAT5B STAT5A SRC IL3 IL2RA FLT3
9
Show member pathways
12.96 NOTCH1 IL3 IL2RA FLT3 FGFR1 BAD
10
Show member pathways
12.89 STAT5B STAT5A SRC CD8A CD4
11
Show member pathways
12.85 STAT5B STAT5A SRC CD4 BAD
12
Show member pathways
12.79 STAT5B STAT5A SRC IL3 FLT3 FGFR1
13
Show member pathways
12.62 STAT5B STAT5A SRC NOTCH1 FGFR1 BAD
14 12.58 STAT5B STAT5A NOTCH1 IL3 IL2RA FLT3
15
Show member pathways
12.57 STAT5B STAT5A NOTCH1 IL2RA CD4
16
Show member pathways
12.56 STAT5B STAT5A SRC CD4 BAD
17 12.52 STAT5B STAT5A IL3 IL2RA CD8A
18
Show member pathways
12.46 STAT5B STAT5A SRC BAD
19
Show member pathways
12.38 STAT5A SRC IL3 FLT3 FGFR1
20
Show member pathways
12.37 STAT5A SRC FLT3 FGFR1 BAD
21
Show member pathways
12.33 STAT5B STAT5A IL3 IL2RA
22 12.32 STAT5B STAT5A IL2RA CD4
23
Show member pathways
12.3 STAT5B STAT5A IL3 FLT3 BAD
24 12.28 STAT5B STAT5A SRC BAD
25
Show member pathways
12.2 SRC IL2RA FGFR1 BAD
26
Show member pathways
12.13 STAT5B STAT5A SRC IL3 BAD
27 12.09 STAT5B STAT5A SRC BAD
28 11.97 SRC NOTCH1 BAD
29
Show member pathways
11.95 STAT5A IL2RA CD8A CD4
30
Show member pathways
11.87 STAT5B STAT5A SRC
31 11.85 STAT5B STAT5A SRC IL3 IL2RA
32
Show member pathways
11.84 STAT5B STAT5A IL3
33
Show member pathways
11.83 ZMYM2 STAT5B STAT5A FGFR1OP2 FGFR1 CUX1
34
Show member pathways
11.79 FLT3 FGFR1 BAD
35 11.77 IL2RA CD8A CD4
36 11.76 IL3 IL2RA FLT3 CD8A CD4
37 11.74 FLT3 CD8A CD4
38
Show member pathways
11.69 STAT5B STAT5A IL2RA
39 11.67 STAT5B STAT5A SRC
40 11.6 STAT5B STAT5A SRC CD4 BAD
41 11.58 STAT5B STAT5A SRC
42 11.54 STAT5B STAT5A SRC
43 11.52 STAT5A NOTCH1 IL3
44 11.5 STAT5B SRC FGFR1
45 11.5 NOTCH1 IL3 IL2RA FLT3 CD8A CD4
46
Show member pathways
11.45 STAT5B STAT5A SRC
47 11.45 STAT5B STAT5A SRC IL2RA
48 11.4 STAT5A NOTCH1 IL2RA CD4
49 11.38 STAT5B STAT5A BAD
50
Show member pathways
11.37 STAT5B STAT5A IL2RA BAD

GO Terms for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

Biological processes related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 NOTCH1 IL3 IL2RA CD8A CD4
2 MAPK cascade GO:0000165 9.78 IL3 IL2RA FLT3 FGFR1
3 positive regulation of MAPK cascade GO:0043410 9.76 FLT3 FGFR1 CD4
4 response to estradiol GO:0032355 9.73 STAT5B CD4 BAD
5 regulation of cell proliferation GO:0042127 9.72 STAT5B STAT5A SRC NOTCH1 FGFR1
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 SRC IL3 CD4
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 SRC FLT3 FGFR1
8 negative regulation of anoikis GO:2000811 9.58 SRC NOTCH1
9 positive regulation of MAP kinase activity GO:0043406 9.58 SRC FLT3 FGFR1
10 inflammatory response to antigenic stimulus GO:0002437 9.57 NOTCH1 IL2RA
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.55 STAT5B STAT5A
12 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.54 STAT5B CD4
13 positive regulation of B cell differentiation GO:0045579 9.52 STAT5B BAD
14 interleukin-9-mediated signaling pathway GO:0038113 9.46 STAT5B STAT5A
15 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT5B STAT5A CD4
16 taurine metabolic process GO:0019530 9.37 STAT5B STAT5A
17 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.35 SRC FLT3 FGFR1 CD8A CD4
18 interleukin-2-mediated signaling pathway GO:0038110 9.33 STAT5B STAT5A IL2RA
19 cytokine-mediated signaling pathway GO:0019221 9.17 STAT5B STAT5A IL3 IL2RA FLT3 CD4

Molecular functions related to Myeloid and Lymphoid Neoplasms Associated with Fgfr1 Abnormalities according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucocorticoid receptor binding GO:0035259 8.62 STAT5B FLT3

Sources for Myeloid and Lymphoid Neoplasms Associated with Fgfr1...

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